PPM1J

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes the serine/threonine protein phosphatase. The mouse homolog of this gene apparently belongs to the protein phosphatase 2C family of genes. The exact function of this gene is not yet known. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neurofilament cytoskeleton organization (GO:0060052)6.94948502
2plasma membrane repair (GO:0001778)6.59610577
3negative regulation of potassium ion transmembrane transporter activity (GO:1901017)6.08879081
4sequestering of actin monomers (GO:0042989)5.80364253
5acrosome reaction (GO:0007340)5.77941228
6negative regulation of potassium ion transmembrane transport (GO:1901380)5.61390338
7chromosome condensation (GO:0030261)5.35974002
8creatine metabolic process (GO:0006600)5.27991729
9skeletal muscle fiber development (GO:0048741)5.09891671
10sarcomere organization (GO:0045214)5.08032418
11DNA packaging (GO:0006323)5.05576503
12muscle filament sliding (GO:0030049)4.95960770
13actin-myosin filament sliding (GO:0033275)4.95960770
14response to muscle activity (GO:0014850)4.87805501
15bundle of His cell to Purkinje myocyte communication (GO:0086069)4.70713080
16regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)4.69666302
17regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)4.58259789
18regulation of relaxation of muscle (GO:1901077)4.57729537
19regulation of translational termination (GO:0006449)4.56335513
20positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)4.53802953
21NADH metabolic process (GO:0006734)4.50819308
22single strand break repair (GO:0000012)4.46128237
23sarcoplasmic reticulum calcium ion transport (GO:0070296)4.38798842
24IMP metabolic process (GO:0046040)4.38718075
25myotube cell development (GO:0014904)4.34876602
26peripheral nervous system neuron development (GO:0048935)4.26072486
27negative regulation of dendrite morphogenesis (GO:0050774)4.22759079
28rRNA methylation (GO:0031167)4.21975367
29sperm motility (GO:0030317)4.20715912
30regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)4.20588744
31carnitine shuttle (GO:0006853)4.19414637
32muscle contraction (GO:0006936)4.18510913
33fusion of sperm to egg plasma membrane (GO:0007342)4.16134181
34acrosome assembly (GO:0001675)4.13202922
35cytidine deamination (GO:0009972)4.05689030
36cytidine metabolic process (GO:0046087)4.05689030
37cytidine catabolic process (GO:0006216)4.05689030
38pyrimidine ribonucleoside catabolic process (GO:0046133)4.03859334
39cell communication involved in cardiac conduction (GO:0086065)3.99264886
40negative regulation of inclusion body assembly (GO:0090084)3.97710008
41tricarboxylic acid cycle (GO:0006099)3.97552741
42actin-mediated cell contraction (GO:0070252)3.94856424
43muscle organ morphogenesis (GO:0048644)3.92877352
44intermediate filament organization (GO:0045109)3.91404858
45regulation of cell communication by electrical coupling (GO:0010649)3.91079405
46regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.91049140
47response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.91038936
48gluconeogenesis (GO:0006094)3.90731947
49membrane depolarization during action potential (GO:0086010)3.90093387
50glucan biosynthetic process (GO:0009250)3.88370672
51glycogen biosynthetic process (GO:0005978)3.88370672
52rRNA modification (GO:0000154)3.88321784
53cell wall macromolecule catabolic process (GO:0016998)3.85689284
54cell wall macromolecule metabolic process (GO:0044036)3.85689284
55glycogen catabolic process (GO:0005980)3.78428132
56cardiac muscle contraction (GO:0060048)3.78298288
57sperm-egg recognition (GO:0035036)3.75782888
58spermatid development (GO:0007286)3.72155069
59carnitine transmembrane transport (GO:1902603)3.70734475
60muscle system process (GO:0003012)3.68744944
61cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.67584509
62regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.63007298
63potassium ion export (GO:0071435)3.62133867
64striated muscle contraction (GO:0006941)3.62130982
65positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.61083716
66cell-cell recognition (GO:0009988)3.60704888
67muscle cell fate commitment (GO:0042693)3.60412747
68desmosome organization (GO:0002934)3.60201134
69positive regulation of myotube differentiation (GO:0010831)3.59996921
70hexose biosynthetic process (GO:0019319)3.56085141
71neuronal action potential (GO:0019228)3.55834025
72cardiac muscle hypertrophy (GO:0003300)3.55691462
73myofibril assembly (GO:0030239)3.55456519
74detection of temperature stimulus (GO:0016048)3.54389781
75muscle fiber development (GO:0048747)3.54267785
76carnitine transport (GO:0015879)3.49998956
77amino-acid betaine transport (GO:0015838)3.49998956
78regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.48404813
79glucan catabolic process (GO:0009251)3.47813097
80binding of sperm to zona pellucida (GO:0007339)3.47274725
81fructose metabolic process (GO:0006000)3.46748563
82response to inactivity (GO:0014854)3.46004230
83chromatin silencing (GO:0006342)3.41480113
84striated muscle hypertrophy (GO:0014897)3.40437946
85regulation of skeletal muscle contraction (GO:0014819)3.40079589
86positive regulation of potassium ion transmembrane transport (GO:1901381)3.38020448
87spermatid nucleus differentiation (GO:0007289)3.37339996
88cell migration in hindbrain (GO:0021535)3.35685528
89ventricular cardiac muscle cell action potential (GO:0086005)3.32260312
90microtubule depolymerization (GO:0007019)3.32230010
91skeletal muscle contraction (GO:0003009)3.32085587
92regulation of membrane repolarization (GO:0060306)3.31483458
93detection of temperature stimulus involved in sensory perception of pain (GO:0050965)3.29882868
94detection of temperature stimulus involved in sensory perception (GO:0050961)3.29882868
95plasma membrane fusion (GO:0045026)3.28912099
96fatty acid transmembrane transport (GO:1902001)3.28598999
97striated muscle adaptation (GO:0014888)3.25523918
98regulation of inclusion body assembly (GO:0090083)3.25044674
99IMP biosynthetic process (GO:0006188)3.24316597
100cardiac myofibril assembly (GO:0055003)3.24000648
101regulation of actin filament-based movement (GO:1903115)3.23928851
102microtubule severing (GO:0051013)3.21503014
103cellular polysaccharide catabolic process (GO:0044247)3.20659072
1042-oxoglutarate metabolic process (GO:0006103)3.19881384
105actomyosin structure organization (GO:0031032)3.19439913
106negative regulation of cardiac muscle cell apoptotic process (GO:0010667)3.18996935
107cardiac muscle tissue morphogenesis (GO:0055008)3.17405760
108glycolytic process (GO:0006096)3.17024665
109cardiac muscle hypertrophy in response to stress (GO:0014898)3.15487555
110muscle hypertrophy in response to stress (GO:0003299)3.15487555
111cardiac muscle adaptation (GO:0014887)3.15487555
112sexual reproduction (GO:0019953)3.14607715
113establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.14547179
114mitochondrion transport along microtubule (GO:0047497)3.14547179
115calcium ion-dependent exocytosis (GO:0017156)3.13998868
116monosaccharide biosynthetic process (GO:0046364)3.13381232
117neuronal action potential propagation (GO:0019227)3.13376265
118ventricular cardiac muscle tissue morphogenesis (GO:0055010)3.12668291
119regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.12201329
120microtubule polymerization or depolymerization (GO:0031109)3.11728935
121skeletal muscle adaptation (GO:0043501)3.10355133
122negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.06961946
123regulation of NFAT protein import into nucleus (GO:0051532)3.06809427
124regulation of potassium ion transmembrane transporter activity (GO:1901016)3.06404103
125synaptonemal complex organization (GO:0070193)3.06291637
126cardiac muscle cell development (GO:0055013)3.06039423
127actin filament-based movement (GO:0030048)3.05776435
128regulation of striated muscle contraction (GO:0006942)3.04691879
129multicellular organism reproduction (GO:0032504)3.02972317
130membrane budding (GO:0006900)3.00460056
131regulation of acyl-CoA biosynthetic process (GO:0050812)2.98474794
132negative regulation of calcium ion transport into cytosol (GO:0010523)2.97570448
133establishment of mitochondrion localization (GO:0051654)2.97446356
134cell communication by electrical coupling (GO:0010644)2.96625844
135sperm capacitation (GO:0048240)2.93514756
136oxaloacetate metabolic process (GO:0006107)2.93282030
137negative regulation of striated muscle cell apoptotic process (GO:0010664)2.93118546
138regulation of coenzyme metabolic process (GO:0051196)2.92386434
139regulation of cofactor metabolic process (GO:0051193)2.92386434
140polysaccharide catabolic process (GO:0000272)2.91970058
141skeletal muscle tissue regeneration (GO:0043403)2.91088444
142glycogen metabolic process (GO:0005977)2.90740951
143myoblast fusion (GO:0007520)2.90324584
144negative regulation of microtubule polymerization (GO:0031115)2.90046071
145regulation of calcium ion transmembrane transporter activity (GO:1901019)2.89836402
146regulation of calcium ion transmembrane transport (GO:1903169)2.89836402
147protein polyglutamylation (GO:0018095)2.89691270
148membrane repolarization (GO:0086009)2.89598109
149L-alpha-amino acid transmembrane transport (GO:1902475)2.89105352
150spermatogenesis (GO:0007283)2.88432754
151regulation of cilium movement (GO:0003352)2.88164309
152negative regulation of ion transmembrane transporter activity (GO:0032413)2.88041304
153male gamete generation (GO:0048232)2.87246054
154striated muscle cell development (GO:0055002)2.86884177
155muscle hypertrophy (GO:0014896)2.86178163
156protein complex localization (GO:0031503)2.86007445
157glucan metabolic process (GO:0044042)2.82507643
158cellular glucan metabolic process (GO:0006073)2.82507643
1594-hydroxyproline metabolic process (GO:0019471)2.81184818
160protein targeting to Golgi (GO:0000042)2.78931257
161muscle tissue morphogenesis (GO:0060415)2.75609515
162skeletal muscle tissue development (GO:0007519)2.71435539
163muscle adaptation (GO:0043500)2.70458439
164polyamine biosynthetic process (GO:0006596)2.66909317
165oxidative phosphorylation (GO:0006119)2.66738674

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat5.29514680
2ZNF263_19887448_ChIP-Seq_K562_Human4.43680251
3ESRRB_18555785_ChIP-Seq_MESCs_Mouse3.49990561
4MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.06613412
5SRY_22984422_ChIP-ChIP_TESTIS_Rat2.78251555
6SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.56649721
7POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.52220034
8KLF4_18358816_ChIP-ChIP_MESCs_Mouse2.51505027
9NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.50951107
10SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.49791820
11NR0B1_18358816_ChIP-ChIP_MESCs_Mouse2.48251161
12MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.38659110
13EZH2_22144423_ChIP-Seq_EOC_Human2.11733723
14BP1_19119308_ChIP-ChIP_Hs578T_Human2.09929067
15BCL3_23251550_ChIP-Seq_MUSCLE_Mouse2.05704519
16TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.96309211
17TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.92958720
18VDR_22108803_ChIP-Seq_LS180_Human1.90492002
19SMC4_20622854_ChIP-Seq_HELA_Human1.86849811
20TBX20_22080862_ChIP-Seq_HEART_Mouse1.85967178
21TBX20_22328084_ChIP-Seq_HEART_Mouse1.85967178
22* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.85847385
23* CTCF_27219007_Chip-Seq_Bcells_Human1.82156681
24BCL6_27268052_Chip-Seq_Bcells_Human1.78248500
25PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.77726497
26ELF1_20517297_ChIP-Seq_JURKAT_Human1.77179799
27YY1_22570637_ChIP-Seq_MALME-3M_Human1.76470583
28RARG_19884340_ChIP-ChIP_MEFs_Mouse1.75468276
29STAT3_1855785_ChIP-Seq_MESCs_Mouse1.75175037
30ESR2_21235772_ChIP-Seq_MCF-7_Human1.71815243
31SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.70168430
32THAP11_20581084_ChIP-Seq_MESCs_Mouse1.67910955
33RUNX_20019798_ChIP-Seq_JUKART_Human1.66732298
34MYC_18555785_ChIP-Seq_MESCs_Mouse1.65478310
35ATF3_27146783_Chip-Seq_COLON_Human1.62109453
36* KDM2B_26808549_Chip-Seq_DND41_Human1.57313753
37POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.57167722
38BCOR_27268052_Chip-Seq_Bcells_Human1.54447853
39HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.53921420
40LXR_22292898_ChIP-Seq_THP-1_Human1.53634523
41SPI1_20517297_ChIP-Seq_HL60_Human1.53194305
42EP300_21415370_ChIP-Seq_HL-1_Mouse1.50836300
43THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.49676601
44P68_20966046_ChIP-Seq_HELA_Human1.49095870
45* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.48034669
46MAF_26560356_Chip-Seq_TH1_Human1.47265291
47MYC_18358816_ChIP-ChIP_MESCs_Mouse1.46807459
48* CTCF_21964334_Chip-Seq_Bcells_Human1.46710338
49* FOXP1_21924763_ChIP-Seq_HESCs_Human1.45265277
50CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.43699996
51* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.43281496
52ELK3_25401928_ChIP-Seq_HUVEC_Human1.43121732
53SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.42772229
54MYC_19079543_ChIP-ChIP_MESCs_Mouse1.41508452
55MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.40898231
56EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.39875655
57NANOG_18692474_ChIP-Seq_MEFs_Mouse1.36285555
58CTCF_27219007_Chip-Seq_ERYTHROID_Human1.35891184
59MAF_26560356_Chip-Seq_TH2_Human1.35254389
60* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.34758830
61RBPJ_22232070_ChIP-Seq_NCS_Mouse1.34466829
62RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.33581979
63HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.33190043
64* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.30570965
65ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.30109611
66TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.29532995
67RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.28355433
68ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.27985168
69NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.27929950
70TET1_21490601_ChIP-Seq_MESCs_Mouse1.27883299
71* CTCF_21964334_ChIP-Seq_BJAB-B_Human1.27655808
72FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.27619902
73* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.27259205
74CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.27041439
75IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.26889886
76RARB_27405468_Chip-Seq_BRAIN_Mouse1.26867747
77* SA1_27219007_Chip-Seq_Bcells_Human1.26848674
78FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.26808964
79ESR1_20079471_ChIP-ChIP_T-47D_Human1.26023767
80* SA1_27219007_Chip-Seq_ERYTHROID_Human1.24275093
81RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.24156867
82STAT4_19710469_ChIP-ChIP_TH1__Mouse1.24090209
83RAC3_21632823_ChIP-Seq_H3396_Human1.24030318
84RUNX1_27514584_Chip-Seq_MCF-7_Human1.23315272
85ZNF274_21170338_ChIP-Seq_K562_Hela1.22566877
86ERG_21242973_ChIP-ChIP_JURKAT_Human1.21547477
87DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.21446368
88RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.20311766
89PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.20255245
90GATA3_21867929_ChIP-Seq_CD8_Mouse1.20212547
91TP63_22573176_ChIP-Seq_HFKS_Human1.19479871
92YY1_21170310_ChIP-Seq_MESCs_Mouse1.19220947
93CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.19099572
94SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.17205075
95NANOG_21062744_ChIP-ChIP_HESCs_Human1.16910476
96UTX_26944678_Chip-Seq_JUKART_Human1.16789233
97RUNX1_26923725_Chip-Seq_HPCs_Mouse1.16621041
98JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.16164886
99E2F7_22180533_ChIP-Seq_HELA_Human1.16047978
100MYC_19030024_ChIP-ChIP_MESCs_Mouse1.15566908
101EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.14325533
102SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.14314464
103SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.14300229
104PHF8_20622854_ChIP-Seq_HELA_Human1.14158215
105SOX2_22085726_ChIP-Seq_NPCs_Mouse1.13938637
106MYC_22102868_ChIP-Seq_BL_Human1.13784449
107RACK7_27058665_Chip-Seq_MCF-7_Human1.13629565
108MYB_26560356_Chip-Seq_TH2_Human1.13344551
109FOXH1_21741376_ChIP-Seq_ESCs_Human1.13057104
110NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.13039417
111TET1_21451524_ChIP-Seq_MESCs_Mouse1.12374865
112CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.11564527
113RARA_24833708_ChIP-Seq_LIVER_Mouse1.11064337
114SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.11021808
115PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.09946686
116PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.09854588
117SOX2_21211035_ChIP-Seq_LN229_Human1.09538294
118CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.09025298
119PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.08544249
120EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.08199708
121HIF1A_21447827_ChIP-Seq_MCF-7_Human1.05982018
122CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.05089231
123EGR1_19032775_ChIP-ChIP_M12_Human1.04722785
124SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.04534081
125DROSHA_22980978_ChIP-Seq_HELA_Human1.04216396
126* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.03922350
127CREB1_26743006_Chip-Seq_LNCaP_Human1.03862397
128OCT4_19829295_ChIP-Seq_ESCs_Human1.02799774
129CTCF_20526341_ChIP-Seq_ESCs_Human1.02626867
130* RAD21_21589869_ChIP-Seq_MESCs_Mouse1.01515455
131* NANOG_20526341_ChIP-Seq_ESCs_Human1.01149302
132VDR_21846776_ChIP-Seq_THP-1_Human1.01078853
133STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.01072083
134KDM2B_26808549_Chip-Seq_K562_Human1.00685092
135KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.00603942
136KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.00375311
137E2F1_20622854_ChIP-Seq_HELA_Human1.00290377
138* OCT4_20526341_ChIP-Seq_ESCs_Human1.00073500
139UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.99798161
140LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.99282079
141CTCF_26484167_Chip-Seq_Bcells_Mouse0.98875346
142FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.98606165
143TCF7_22412390_ChIP-Seq_EML_Mouse0.98542072
144ETS1_21867929_ChIP-Seq_TH2_Mouse0.98541377
145* SPI1_23127762_ChIP-Seq_K562_Human0.98457085
146RUNX1_22412390_ChIP-Seq_EML_Mouse0.98300748
147FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.97018110
148TDRD3_21172665_ChIP-Seq_MCF-7_Human0.96872537
149PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.96509005
150TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.94842615
151P53_21459846_ChIP-Seq_SAOS-2_Human0.94395124

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002735_abnormal_chemical_nociception4.92933426
2MP0005451_abnormal_body_composition4.52430031
3MP0005410_abnormal_fertilization4.15690235
4MP0003646_muscle_fatigue4.11727660
5MP0000749_muscle_degeneration3.99501670
6MP0004084_abnormal_cardiac_muscle3.93704531
7MP0000751_myopathy3.87317628
8MP0002837_dystrophic_cardiac_calcinosis3.70092806
9MP0004036_abnormal_muscle_relaxation3.55516694
10MP0010234_abnormal_vibrissa_follicle3.45108375
11MP0002736_abnormal_nociception_after3.38959563
12MP0004858_abnormal_nervous_system3.23085108
13MP0001968_abnormal_touch/_nociception3.22769256
14MP0001986_abnormal_taste_sensitivity3.13343970
15MP0004145_abnormal_muscle_electrophysio3.06813395
16MP0004215_abnormal_myocardial_fiber2.43900951
17MP0002269_muscular_atrophy2.42992451
18MP0004270_analgesia2.41948828
19MP0004087_abnormal_muscle_fiber2.29905618
20MP0000747_muscle_weakness2.23384123
21MP0002972_abnormal_cardiac_muscle2.10852599
22MP0005330_cardiomyopathy2.08073403
23MP0002106_abnormal_muscle_physiology2.01973864
24MP0002733_abnormal_thermal_nociception2.00501542
25MP0002254_reproductive_system_inflammat1.97168151
26MP0005620_abnormal_muscle_contractility1.87900129
27MP0008775_abnormal_heart_ventricle1.85945359
28MP0000759_abnormal_skeletal_muscle1.84053702
29MP0000750_abnormal_muscle_regeneration1.76042748
30MP0003806_abnormal_nucleotide_metabolis1.76039839
31MP0003941_abnormal_skin_development1.75514847
32MP0002734_abnormal_mechanical_nocicepti1.72133650
33MP0000733_abnormal_muscle_development1.70097971
34MP0000678_abnormal_parathyroid_gland1.62418160
35MP0001544_abnormal_cardiovascular_syste1.60949389
36MP0005385_cardiovascular_system_phenoty1.60949389
37MP0001348_abnormal_lacrimal_gland1.60831612
38MP0006276_abnormal_autonomic_nervous1.60187638
39MP0006036_abnormal_mitochondrial_physio1.53534979
40MP0001970_abnormal_pain_threshold1.51896879
41MP0004130_abnormal_muscle_cell1.51872685
42MP0004510_myositis1.51532064
43MP0003137_abnormal_impulse_conducting1.50720216
44MP0003221_abnormal_cardiomyocyte_apopto1.49974677
45MP0005369_muscle_phenotype1.49896265
46MP0010630_abnormal_cardiac_muscle1.47554017
47MP0004484_altered_response_of1.46615837
48MP0004233_abnormal_muscle_weight1.45300311
49MP0002108_abnormal_muscle_morphology1.37636404
50MP0010030_abnormal_orbit_morphology1.32059151
51MP0002822_catalepsy1.30731419
52MP0004147_increased_porphyrin_level1.28257822
53MP0003698_abnormal_male_reproductive1.27570358
54MP0003045_fibrosis1.26044073
55MP0003763_abnormal_thymus_physiology1.25421563
56MP0002127_abnormal_cardiovascular_syste1.24330933
57MP0003329_amyloid_beta_deposits1.23571371
58MP0005375_adipose_tissue_phenotype1.15430396
59MP0003693_abnormal_embryo_hatching1.12593728
60MP0009672_abnormal_birth_weight1.09633855
61MP0004957_abnormal_blastocyst_morpholog1.09486404
62MP0004085_abnormal_heartbeat1.08234350
63MP0002249_abnormal_larynx_morphology1.05000996
64MP0001929_abnormal_gametogenesis1.01883095
65MP0002751_abnormal_autonomic_nervous1.01646031
66MP0004859_abnormal_synaptic_plasticity1.00872140
67MP0000579_abnormal_nail_morphology1.00607641
68MP0001849_ear_inflammation1.00498224
69MP0003950_abnormal_plasma_membrane1.00202055
70MP0003828_pulmonary_edema0.99350920
71MP0000604_amyloidosis0.97558712
72MP0006035_abnormal_mitochondrial_morpho0.97513715
73MP0003566_abnormal_cell_adhesion0.95030302
74MP0005670_abnormal_white_adipose0.94490859
75MP0002796_impaired_skin_barrier0.92989320
76MP0003718_maternal_effect0.92028034
77MP0002653_abnormal_ependyma_morphology0.91074637
78MP0001346_abnormal_lacrimal_gland0.90589429
79MP0000003_abnormal_adipose_tissue0.89530848
80MP0002332_abnormal_exercise_endurance0.89475096
81MP0005671_abnormal_response_to0.88540955
82MP0001299_abnormal_eye_distance/0.87779659
83MP0006138_congestive_heart_failure0.87363897
84MP0005423_abnormal_somatic_nervous0.85099700
85MP0003656_abnormal_erythrocyte_physiolo0.84982820
86MP0010352_gastrointestinal_tract_polyps0.84289437
87MP0005666_abnormal_adipose_tissue0.82448937
88MP0003866_abnormal_defecation0.82078877
89MP0003879_abnormal_hair_cell0.81614946
90MP0005623_abnormal_meninges_morphology0.78167234
91MP0004185_abnormal_adipocyte_glucose0.74923226
92MP0002184_abnormal_innervation0.70654754
93MP0003878_abnormal_ear_physiology0.70256952
94MP0005377_hearing/vestibular/ear_phenot0.70256952
95MP0005083_abnormal_biliary_tract0.70248476
96MP0000343_altered_response_to0.68789986
97MP0001661_extended_life_span0.68773391
98MP0000013_abnormal_adipose_tissue0.68257780
99MP0000762_abnormal_tongue_morphology0.68208264
100MP0003705_abnormal_hypodermis_morpholog0.67695092
101MP0004811_abnormal_neuron_physiology0.67289910
102MP0003011_delayed_dark_adaptation0.66361225
103MP0002067_abnormal_sensory_capabilities0.63841712
104MP0000266_abnormal_heart_morphology0.63636614
105MP0008260_abnormal_autophagy0.62906481
106MP0002132_abnormal_respiratory_system0.61588542
107MP0005266_abnormal_metabolism0.61175669
108MP0003077_abnormal_cell_cycle0.60022723
109MP0000358_abnormal_cell_content/0.59252367
110MP0002161_abnormal_fertility/fecundity0.59235319
111MP0010307_abnormal_tumor_latency0.58185523
112MP0000858_altered_metastatic_potential0.57983075
113MP0005023_abnormal_wound_healing0.57432266
114MP0003111_abnormal_nucleus_morphology0.57334417
115MP0001730_embryonic_growth_arrest0.56552213
116MP0004947_skin_inflammation0.56165949
117MP0005165_increased_susceptibility_to0.55816979
118MP0002234_abnormal_pharynx_morphology0.55783850
119MP0000467_abnormal_esophagus_morphology0.55601156
120MP0008877_abnormal_DNA_methylation0.55184905
121MP0002272_abnormal_nervous_system0.54436639
122MP0001270_distended_abdomen0.53786818
123MP0000534_abnormal_ureter_morphology0.50773664
124MP0008932_abnormal_embryonic_tissue0.50757078
125MP0002080_prenatal_lethality0.46567174
126MP0000955_abnormal_spinal_cord0.46102706
127MP0001145_abnormal_male_reproductive0.45509928
128MP0001529_abnormal_vocalization0.45423151
129MP0002229_neurodegeneration0.44618315
130MP0002210_abnormal_sex_determination0.43729768
131MP0002160_abnormal_reproductive_system0.43104090
132MP0009333_abnormal_splenocyte_physiolog0.42754701
133MP0001672_abnormal_embryogenesis/_devel0.42486438
134MP0005380_embryogenesis_phenotype0.42486438
135MP0005332_abnormal_amino_acid0.42056414
136MP0000049_abnormal_middle_ear0.41022706
137MP0009697_abnormal_copulation0.41001792
138MP0002971_abnormal_brown_adipose0.40880500
139MP0002909_abnormal_adrenal_gland0.40861281
140MP0003123_paternal_imprinting0.40496863
141MP0001485_abnormal_pinna_reflex0.40301156
142MP0008770_decreased_survivor_rate0.40286953
143MP0008569_lethality_at_weaning0.39939753

Predicted human phenotypes

RankGene SetZ-score
1Ulnar claw (HP:0001178)6.42501945
2Hyporeflexia of lower limbs (HP:0002600)6.26853360
3Exercise-induced muscle cramps (HP:0003710)5.49260428
4Exercise-induced myalgia (HP:0003738)5.38413315
5Sudden death (HP:0001699)5.04107933
6Distal arthrogryposis (HP:0005684)4.84774829
7Centrally nucleated skeletal muscle fibers (HP:0003687)4.65828118
8Calf muscle hypertrophy (HP:0008981)4.62642495
9Muscle hypertrophy of the lower extremities (HP:0008968)4.55706248
10Muscle fiber splitting (HP:0003555)4.50011257
11Areflexia of lower limbs (HP:0002522)4.49229888
12Myoglobinuria (HP:0002913)4.47663339
13Myotonia (HP:0002486)4.34765432
14Distal lower limb muscle weakness (HP:0009053)4.10906170
15Foot dorsiflexor weakness (HP:0009027)4.08353338
16Rhabdomyolysis (HP:0003201)3.95979284
17Calcaneovalgus deformity (HP:0001848)3.91063038
18Abnormality of the foot musculature (HP:0001436)3.85986935
19Muscle stiffness (HP:0003552)3.85157335
20Muscle fiber inclusion bodies (HP:0100299)3.79781659
21Ventricular tachycardia (HP:0004756)3.77103280
22Difficulty climbing stairs (HP:0003551)3.71894472
23Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.69583217
24Difficulty running (HP:0009046)3.68325682
25EMG: myopathic abnormalities (HP:0003458)3.64929344
26Rimmed vacuoles (HP:0003805)3.63652532
27Palpitations (HP:0001962)3.63468296
28Increased connective tissue (HP:0009025)3.62832706
29Bundle branch block (HP:0011710)3.57467506
30Asymmetric septal hypertrophy (HP:0001670)3.50721188
31Ventricular fibrillation (HP:0001663)3.46070491
32Pheochromocytoma (HP:0002666)3.39431645
33Steppage gait (HP:0003376)3.39174585
34Segmental peripheral demyelination/remyelination (HP:0003481)3.38533589
35Deformed tarsal bones (HP:0008119)3.36887385
36Abnormality of the calf musculature (HP:0001430)3.36881946
37Nemaline bodies (HP:0003798)3.31963391
38EMG: neuropathic changes (HP:0003445)3.27045621
39Hyperkalemia (HP:0002153)3.22565702
40Neuroendocrine neoplasm (HP:0100634)3.16508798
41Subaortic stenosis (HP:0001682)3.09353341
42Abnormality of the left ventricular outflow tract (HP:0011103)3.09353341
43Malignant hyperthermia (HP:0002047)2.97115798
44Atrial fibrillation (HP:0005110)2.93033072
45Myokymia (HP:0002411)2.89442721
46Myopathic facies (HP:0002058)2.86037120
47Syncope (HP:0001279)2.84424879
48Termporal pattern (HP:0011008)2.83474212
49Insidious onset (HP:0003587)2.83474212
50Lipoatrophy (HP:0100578)2.81761658
51Distal lower limb amyotrophy (HP:0008944)2.77750539
52Nasal polyposis (HP:0100582)2.75596675
53Primary atrial arrhythmia (HP:0001692)2.74522421
54Right ventricular cardiomyopathy (HP:0011663)2.68705616
55Supraventricular tachycardia (HP:0004755)2.66596013
56Supraventricular arrhythmia (HP:0005115)2.63729115
57Prolonged QT interval (HP:0001657)2.62099065
58Hammertoe (HP:0001765)2.61299537
59Absent phalangeal crease (HP:0006109)2.58999385
60Type 1 muscle fiber predominance (HP:0003803)2.57614942
61Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.55915667
62Heart block (HP:0012722)2.55882645
63Ventricular arrhythmia (HP:0004308)2.50934659
64Mildly elevated creatine phosphokinase (HP:0008180)2.47597399
65Impaired pain sensation (HP:0007328)2.47117433
66Abnormality of pain sensation (HP:0010832)2.47117433
67Decreased number of peripheral myelinated nerve fibers (HP:0003380)2.44626427
68Bulbar palsy (HP:0001283)2.41851893
69Abnormal atrioventricular conduction (HP:0005150)2.41107554
70Abnormality of the vocal cords (HP:0008777)2.40610189
71Abnormality of the nasal mucosa (HP:0000433)2.40351692
72Hypercortisolism (HP:0001578)2.35972051
73Action tremor (HP:0002345)2.35116779
74Decreased motor nerve conduction velocity (HP:0003431)2.34551726
75Abnormality of the calcaneus (HP:0008364)2.33776044
76Lower limb amyotrophy (HP:0007210)2.32215177
77Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.29373365
78Weak cry (HP:0001612)2.26973142
79Urinary urgency (HP:0000012)2.24892663
80Dilated cardiomyopathy (HP:0001644)2.21979285
81Spinal rigidity (HP:0003306)2.19146495
82Absent/shortened dynein arms (HP:0200106)2.17430082
83Dynein arm defect of respiratory motile cilia (HP:0012255)2.17430082
84Distal sensory impairment (HP:0002936)2.17144045
85Atrioventricular block (HP:0001678)2.16049810
86Abnormal finger flexion creases (HP:0006143)2.13408081
87Frequent falls (HP:0002359)2.12937098
88Impaired proprioception (HP:0010831)2.08498671
89Fasciculations (HP:0002380)2.08239474
90Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.05868261
91Ulnar deviation of the wrist (HP:0003049)2.02317694
92Neck muscle weakness (HP:0000467)1.99387270
93Generalized muscle weakness (HP:0003324)1.98991872
94Waddling gait (HP:0002515)1.97573781
95Abnormality of skeletal muscle fiber size (HP:0012084)1.95944862
96Fetal akinesia sequence (HP:0001989)1.95789285
97Increased variability in muscle fiber diameter (HP:0003557)1.95720433
98Abnormal EKG (HP:0003115)1.93727733
99Gowers sign (HP:0003391)1.93233807
100Rapidly progressive (HP:0003678)1.92830669
101Muscular dystrophy (HP:0003560)1.91051663
102Muscle fibrillation (HP:0010546)1.90899805
103Neoplasm of the peripheral nervous system (HP:0100007)1.88982261
104Scapular winging (HP:0003691)1.88653093
105Slender build (HP:0001533)1.88063542
106Exercise intolerance (HP:0003546)1.85562155
107Progressive muscle weakness (HP:0003323)1.83541719
108Facial diplegia (HP:0001349)1.82807942
109Hypoplasia of the brainstem (HP:0002365)1.82631856
110Aplasia/Hypoplasia of the brainstem (HP:0007362)1.82631856
111Ragged-red muscle fibers (HP:0003200)1.81713276
112Round ear (HP:0100830)1.81207704
113Dysmetric saccades (HP:0000641)1.80487261
114Severe visual impairment (HP:0001141)1.77070180
115Increased purine levels (HP:0004368)1.76424450
116Hyperuricemia (HP:0002149)1.76424450
117Acute necrotizing encephalopathy (HP:0006965)1.74961357
118Onion bulb formation (HP:0003383)1.74889672
119Abnormal mitochondria in muscle tissue (HP:0008316)1.74378547
120Fatigable weakness (HP:0003473)1.72426297
121Abnormality of the neuromuscular junction (HP:0003398)1.72426297
122Overlapping toe (HP:0001845)1.72133154
123Shoulder girdle muscle weakness (HP:0003547)1.68573052
124Limb-girdle muscle atrophy (HP:0003797)1.65722986
125Increased intramyocellular lipid droplets (HP:0012240)1.65670117
126Bell-shaped thorax (HP:0001591)1.65042106
127Paralysis (HP:0003470)1.64655074
128Limb-girdle muscle weakness (HP:0003325)1.64524577
129Muscle fiber atrophy (HP:0100295)1.64226681
130Nonprogressive disorder (HP:0003680)1.64078540
131Resting tremor (HP:0002322)1.63250063
132Stridor (HP:0010307)1.62646340
133Hip contracture (HP:0003273)1.61799470
134Bowel incontinence (HP:0002607)1.60138198
135Pelvic girdle muscle weakness (HP:0003749)1.56136092
136Respiratory insufficiency due to muscle weakness (HP:0002747)1.54404715
137Abnormality of the shoulder girdle musculature (HP:0001435)1.53348874
138Short palpebral fissure (HP:0012745)1.51635412
139Abnormal large intestine physiology (HP:0012700)1.50035570
140Increased muscle lipid content (HP:0009058)1.48840404
141Nasal speech (HP:0001611)1.47944873
142Easy fatigability (HP:0003388)1.47501940
143Hypoalphalipoproteinemia (HP:0003233)1.46303364
144Abnormality of the hip-girdle musculature (HP:0001445)1.46178725
145Abnormality of the musculature of the pelvis (HP:0001469)1.46178725
146Proximal amyotrophy (HP:0007126)1.45437956
147Abnormality of potassium homeostasis (HP:0011042)1.44186007
148Multiple enchondromatosis (HP:0005701)1.43037934
149Cholelithiasis (HP:0001081)1.39900160

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LMTK24.68009515
2PDK44.21611499
3PDK34.21611499
4MAPKAPK33.49694366
5PLK43.33102659
6PHKG23.08905999
7PHKG13.08905999
8OBSCN3.03225136
9TTN3.01465850
10TESK12.98896822
11PDK22.67057279
12PIK3CG2.64284424
13NEK12.35215224
14LIMK12.34194919
15PKN22.07731580
16KSR21.99482253
17LATS21.82800899
18MINK11.71353492
19PRKD31.56529288
20PIK3CA1.54004426
21NEK91.48116420
22MAP2K61.46101443
23MYLK1.39087250
24MAP3K91.38581202
25MARK31.30954969
26TXK1.28898009
27MAP3K111.24205758
28MAP3K121.21998004
29MAP4K11.21551263
30WNK41.21258339
31RIPK11.18829128
32TTK1.16201847
33MAP2K31.14021099
34RET1.13824582
35RPS6KB21.13628620
36MAP3K21.11248390
37DYRK1B1.08070661
38CDK191.06363867
39TESK21.05634148
40ZAP701.05224653
41STK241.04855421
42PRKG21.03576972
43DDR21.03486207
44BRD41.01696199
45WNK11.01377458
46PBK1.00703778
47NME10.98905143
48ARAF0.98530025
49BRAF0.97587617
50FLT30.96895913
51ICK0.95949823
52STK380.95720275
53PTK2B0.94933902
54BUB10.94508716
55CDK120.93284705
56FGFR40.91956839
57SMG10.91453707
58PINK10.91254664
59STK100.89479645
60TRIB30.89446317
61GRK50.88917547
62TAOK10.88496629
63MAP3K130.85652838
64MAP3K100.85223317
65STK390.84594007
66PDK10.82075601
67MAP3K10.78700640
68CAMK2G0.77997119
69FER0.75662831
70VRK20.74912978
71KDR0.74071598
72NTRK30.72087656
73AKT20.71071066
74MAP2K20.66682016
75SIK30.66460942
76MAP2K40.66190108
77EPHA30.64995006
78TSSK60.64875781
79DMPK0.63164339
80PNCK0.61653208
81ITK0.61530825
82PRKG10.61134324
83INSRR0.60321626
84SCYL20.59732856
85SIK10.58209592
86BMX0.57292791
87CDK70.56072467
88MAP2K10.54383281
89MAP3K70.54182733
90TAF10.53857171
91STK38L0.52859097
92MTOR0.52735053
93RPS6KA10.51096313
94JAK10.50788512
95PAK60.50740454
96MARK10.49953590
97PDPK10.48738857
98PLK20.48405768
99MST40.47849664
100NTRK10.47584071
101UHMK10.47253340
102FGFR30.45838983
103NEK60.45641290
104JAK30.45209804
105MST1R0.44933488
106CAMK10.43858415
107ROCK10.43813437
108TAOK20.43195202
109CDC42BPA0.43032810
110RPS6KA20.42498659
111STK160.42371304
112LRRK20.42155391
113MAPK100.41968016
114EEF2K0.41958439
115PTK20.40192030
116EPHB10.40054787
117CAMK40.39849867
118MAPK120.39321891
119AURKA0.39297499
120CDK10.38383039
121PRKAA20.38255812
122MAP3K50.37293172
123CDK20.36374121
124MOS0.36099089
125MUSK0.35953362
126PLK10.35294906
127TNIK0.35062421
128GRK70.34919632
129CAMK2A0.33896434
130MAPK150.33365593
131PRKAA10.32780380
132EPHA20.32358136
133MAP3K80.32353072
134GSK3B0.32016131
135DYRK20.31391641
136MAP3K40.31167463
137RPS6KL10.30574394
138RPS6KC10.30574394
139NME20.29290718
140PAK10.29222058
141NLK0.28014747
142LATS10.27742051
143CHEK10.26846324
144MARK20.26598802
145CDC70.25760953
146ALK0.25160942
147CCNB10.24911461
148MAP3K30.24570471
149ROCK20.24450884
150SGK10.24336544
151PRKD10.24055984
152LCK0.23659130
153ILK0.23313813
154TRPM70.23249968
155TYK20.23098346
156DAPK30.23084899
157CAMK2D0.22430559
158PAK30.21533434

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000204.19650673
2Cardiac muscle contraction_Homo sapiens_hsa042603.61087770
3Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.45715442
4Parkinsons disease_Homo sapiens_hsa050122.41044063
5Arginine and proline metabolism_Homo sapiens_hsa003302.38296996
6Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.37767127
7Pyruvate metabolism_Homo sapiens_hsa006202.31859597
8Glycolysis / Gluconeogenesis_Homo sapiens_hsa000102.31307013
92-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.28803998
10Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.14502712
11Arginine biosynthesis_Homo sapiens_hsa002202.09665155
12Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.09626258
13Oxidative phosphorylation_Homo sapiens_hsa001902.04328605
14Dilated cardiomyopathy_Homo sapiens_hsa054142.01026610
15Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.97187299
16Carbon metabolism_Homo sapiens_hsa012001.93940010
17Viral myocarditis_Homo sapiens_hsa054161.93486407
18Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.90346860
19Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.84771316
20Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.84130117
21Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.69126244
22Huntingtons disease_Homo sapiens_hsa050161.68080053
23Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.66609615
24Glucagon signaling pathway_Homo sapiens_hsa049221.64472913
25Central carbon metabolism in cancer_Homo sapiens_hsa052301.59995881
26Alzheimers disease_Homo sapiens_hsa050101.58399167
27Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.56031072
28Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.52989235
29Insulin signaling pathway_Homo sapiens_hsa049101.51179650
30Fructose and mannose metabolism_Homo sapiens_hsa000511.45232794
31Antigen processing and presentation_Homo sapiens_hsa046121.35584352
32Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.29622227
33Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.28617317
34Proteasome_Homo sapiens_hsa030501.28081029
35RNA transport_Homo sapiens_hsa030131.26448267
36VEGF signaling pathway_Homo sapiens_hsa043701.26232131
37Circadian rhythm_Homo sapiens_hsa047101.24224088
38Carbohydrate digestion and absorption_Homo sapiens_hsa049731.23452047
39Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.21880894
40Dorso-ventral axis formation_Homo sapiens_hsa043201.20566865
41T cell receptor signaling pathway_Homo sapiens_hsa046601.18539887
42Propanoate metabolism_Homo sapiens_hsa006401.18383523
43Salmonella infection_Homo sapiens_hsa051321.15408803
44Phenylalanine metabolism_Homo sapiens_hsa003601.15198395
45Primary immunodeficiency_Homo sapiens_hsa053401.14905128
46Oocyte meiosis_Homo sapiens_hsa041141.14567227
47HIF-1 signaling pathway_Homo sapiens_hsa040661.13460765
48Synaptic vesicle cycle_Homo sapiens_hsa047211.12801119
49Sulfur relay system_Homo sapiens_hsa041221.11617562
50Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.10563966
51Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.03576338
52Thyroid cancer_Homo sapiens_hsa052160.99972922
53Biosynthesis of amino acids_Homo sapiens_hsa012300.99960118
54Graft-versus-host disease_Homo sapiens_hsa053320.95694300
55Insulin resistance_Homo sapiens_hsa049310.94418947
56Renin-angiotensin system_Homo sapiens_hsa046140.92990703
57Galactose metabolism_Homo sapiens_hsa000520.87689892
58Fatty acid elongation_Homo sapiens_hsa000620.86868634
59Cysteine and methionine metabolism_Homo sapiens_hsa002700.86567548
60Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.82037168
61Tight junction_Homo sapiens_hsa045300.80565742
62mRNA surveillance pathway_Homo sapiens_hsa030150.79917239
63Fatty acid degradation_Homo sapiens_hsa000710.79537442
64Endocytosis_Homo sapiens_hsa041440.77006277
65Epstein-Barr virus infection_Homo sapiens_hsa051690.76145488
66cGMP-PKG signaling pathway_Homo sapiens_hsa040220.74386418
67Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.73715652
68Mineral absorption_Homo sapiens_hsa049780.73253392
69Pentose phosphate pathway_Homo sapiens_hsa000300.72962067
70Starch and sucrose metabolism_Homo sapiens_hsa005000.70624136
71Thyroid hormone signaling pathway_Homo sapiens_hsa049190.69813262
72DNA replication_Homo sapiens_hsa030300.68406290
73Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.67884952
74Adipocytokine signaling pathway_Homo sapiens_hsa049200.67295688
75Neurotrophin signaling pathway_Homo sapiens_hsa047220.66670982
76Base excision repair_Homo sapiens_hsa034100.66491325
77Purine metabolism_Homo sapiens_hsa002300.66226461
78Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.66111621
79Toxoplasmosis_Homo sapiens_hsa051450.65066326
80Bile secretion_Homo sapiens_hsa049760.61956155
81Insulin secretion_Homo sapiens_hsa049110.61271216
82Fatty acid biosynthesis_Homo sapiens_hsa000610.59922766
83Oxytocin signaling pathway_Homo sapiens_hsa049210.59630782
84Mismatch repair_Homo sapiens_hsa034300.59081447
85Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.55548904
86Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.55252693
87Calcium signaling pathway_Homo sapiens_hsa040200.55187239
88Phosphatidylinositol signaling system_Homo sapiens_hsa040700.54374544
89Taste transduction_Homo sapiens_hsa047420.54323597
90mTOR signaling pathway_Homo sapiens_hsa041500.53918141
91Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.53405935
92Glycerophospholipid metabolism_Homo sapiens_hsa005640.51008303
93Type II diabetes mellitus_Homo sapiens_hsa049300.50747139
94Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.50468778
95Ribosome_Homo sapiens_hsa030100.49703612
96Prolactin signaling pathway_Homo sapiens_hsa049170.49412768
97Regulation of actin cytoskeleton_Homo sapiens_hsa048100.49336060
98Cyanoamino acid metabolism_Homo sapiens_hsa004600.49139450
99Fat digestion and absorption_Homo sapiens_hsa049750.49015747
100AMPK signaling pathway_Homo sapiens_hsa041520.48693864
101Nitrogen metabolism_Homo sapiens_hsa009100.48587284
102Glycerolipid metabolism_Homo sapiens_hsa005610.47545197
103Adherens junction_Homo sapiens_hsa045200.46697115
104Vascular smooth muscle contraction_Homo sapiens_hsa042700.45647722
105Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.44474909
106Circadian entrainment_Homo sapiens_hsa047130.44178438
107Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.43464258
108Shigellosis_Homo sapiens_hsa051310.43422974
109Vitamin B6 metabolism_Homo sapiens_hsa007500.41329621
110Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.40999285
111Olfactory transduction_Homo sapiens_hsa047400.40505847
112Fatty acid metabolism_Homo sapiens_hsa012120.38580645
113Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.38139499
114Gastric acid secretion_Homo sapiens_hsa049710.37909751
115Aldosterone synthesis and secretion_Homo sapiens_hsa049250.37834330
116Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.37413636
117Longevity regulating pathway - mammal_Homo sapiens_hsa042110.37373631
118Leukocyte transendothelial migration_Homo sapiens_hsa046700.37249632
119Long-term potentiation_Homo sapiens_hsa047200.36960137
120Butanoate metabolism_Homo sapiens_hsa006500.36347752
121Long-term depression_Homo sapiens_hsa047300.34457892
122Metabolic pathways_Homo sapiens_hsa011000.33434128
123Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.33366001
124Lysine degradation_Homo sapiens_hsa003100.33302263
125Estrogen signaling pathway_Homo sapiens_hsa049150.32757960
126Apoptosis_Homo sapiens_hsa042100.32119374
127RNA polymerase_Homo sapiens_hsa030200.30631852
128Viral carcinogenesis_Homo sapiens_hsa052030.30492772
129beta-Alanine metabolism_Homo sapiens_hsa004100.30216482
130Measles_Homo sapiens_hsa051620.29931176
131MAPK signaling pathway_Homo sapiens_hsa040100.29658236
132Spliceosome_Homo sapiens_hsa030400.28126214
133Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.28107444
134One carbon pool by folate_Homo sapiens_hsa006700.27632186
135GnRH signaling pathway_Homo sapiens_hsa049120.27561379
136Allograft rejection_Homo sapiens_hsa053300.27200844
137Collecting duct acid secretion_Homo sapiens_hsa049660.26415237
138Inositol phosphate metabolism_Homo sapiens_hsa005620.26228529
139Cholinergic synapse_Homo sapiens_hsa047250.25667406
140Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.24727297
141Endometrial cancer_Homo sapiens_hsa052130.24727195
142Jak-STAT signaling pathway_Homo sapiens_hsa046300.23928512

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