PPM1K

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the PPM family of Mn2+/Mg2+-dependent protein phosphatases. The encoded protein, essential for cell survival and development, is targeted to the mitochondria where it plays a key role in regulation of the mitochondrial permeability transition pore. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)4.26913962
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.26913962
3neurotransmitter-gated ion channel clustering (GO:0072578)4.26195702
4aromatic amino acid family catabolic process (GO:0009074)4.19387278
5tryptophan catabolic process (GO:0006569)4.15751579
6indole-containing compound catabolic process (GO:0042436)4.15751579
7indolalkylamine catabolic process (GO:0046218)4.15751579
8presynaptic membrane assembly (GO:0097105)4.03752130
9behavioral response to nicotine (GO:0035095)4.03732827
10L-phenylalanine metabolic process (GO:0006558)3.87599396
11erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.87599396
12tryptophan metabolic process (GO:0006568)3.84744523
13low-density lipoprotein particle remodeling (GO:0034374)3.74722661
14cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.70163086
15kynurenine metabolic process (GO:0070189)3.68557782
16regulation of cholesterol esterification (GO:0010872)3.67694609
17detection of calcium ion (GO:0005513)3.67575232
18negative regulation of cytosolic calcium ion concentration (GO:0051481)3.64175913
19bile acid biosynthetic process (GO:0006699)3.62773594
20presynaptic membrane organization (GO:0097090)3.60817118
21high-density lipoprotein particle remodeling (GO:0034375)3.56297135
22regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.56262507
23regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.52890566
24regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.51674491
25membrane depolarization during action potential (GO:0086010)3.43533807
26regulation of cell communication by electrical coupling (GO:0010649)3.42691058
27neuronal action potential (GO:0019228)3.39402385
28regulation of membrane repolarization (GO:0060306)3.39182211
29negative regulation of synaptic transmission, GABAergic (GO:0032229)3.34899239
30coenzyme catabolic process (GO:0009109)3.34489744
31glyoxylate metabolic process (GO:0046487)3.32301627
32relaxation of cardiac muscle (GO:0055119)3.30482961
33triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.30187487
34cellular ketone body metabolic process (GO:0046950)3.29168066
35oxaloacetate metabolic process (GO:0006107)3.28571603
36dicarboxylic acid biosynthetic process (GO:0043650)3.24175019
37synaptic vesicle docking involved in exocytosis (GO:0016081)3.22120313
38positive regulation of potassium ion transmembrane transport (GO:1901381)3.14249647
39regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.14211136
40action potential (GO:0001508)3.12025294
41regulation of actin filament-based movement (GO:1903115)3.11612252
42succinate metabolic process (GO:0006105)3.11580602
43protein-lipid complex remodeling (GO:0034368)3.11306641
44macromolecular complex remodeling (GO:0034367)3.11306641
45plasma lipoprotein particle remodeling (GO:0034369)3.11306641
46reverse cholesterol transport (GO:0043691)3.10647665
47amine catabolic process (GO:0009310)3.10021600
48cellular biogenic amine catabolic process (GO:0042402)3.10021600
49NAD biosynthetic process (GO:0009435)3.06362603
50regulation of action potential (GO:0098900)3.05670719
51membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.05615323
52ionotropic glutamate receptor signaling pathway (GO:0035235)3.04140587
53regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.03067964
54indolalkylamine metabolic process (GO:0006586)3.02647221
55dendritic spine morphogenesis (GO:0060997)3.01307790
56indole-containing compound metabolic process (GO:0042430)2.99566355
57potassium ion import (GO:0010107)2.99289211
58vocalization behavior (GO:0071625)2.97914112
59positive regulation of action potential (GO:0045760)2.97252654
60phospholipid efflux (GO:0033700)2.96366822
61neuron cell-cell adhesion (GO:0007158)2.96010460
62regulation of cardiac muscle cell contraction (GO:0086004)2.95940786
63startle response (GO:0001964)2.95325916
64aromatic amino acid family metabolic process (GO:0009072)2.95173549
65bile acid metabolic process (GO:0008206)2.93890292
66NAD metabolic process (GO:0019674)2.93165081
67urea metabolic process (GO:0019627)2.92078310
68urea cycle (GO:0000050)2.92078310
69cell communication by electrical coupling (GO:0010644)2.92053827
70phospholipid homeostasis (GO:0055091)2.89116306
71positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.88227884
72glutamate secretion (GO:0014047)2.87650317
73serotonin metabolic process (GO:0042428)2.87038140
74regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.86832817
75glutamate receptor signaling pathway (GO:0007215)2.86418124
76cAMP catabolic process (GO:0006198)2.84653272
77glutamate metabolic process (GO:0006536)2.84117872
78alpha-amino acid catabolic process (GO:1901606)2.83715834
79cofactor catabolic process (GO:0051187)2.83470377
80regulation of fibrinolysis (GO:0051917)2.83312155
81complement activation, alternative pathway (GO:0006957)2.82843373
82cholesterol efflux (GO:0033344)2.82257594
83ketone body metabolic process (GO:1902224)2.82080287
84membrane repolarization during action potential (GO:0086011)2.81833831
85cellular potassium ion homeostasis (GO:0030007)2.81245191
86membrane repolarization (GO:0086009)2.81067603
87cardiac conduction (GO:0061337)2.80596349
88postsynaptic membrane organization (GO:0001941)2.78463382
89multicellular organismal signaling (GO:0035637)2.78043528
90cell communication involved in cardiac conduction (GO:0086065)2.77522502
91NADH metabolic process (GO:0006734)2.76474553
92transmission of nerve impulse (GO:0019226)2.76147710
93synaptic transmission, glutamatergic (GO:0035249)2.72513745
94regulation of relaxation of muscle (GO:1901077)2.72243785
95dicarboxylic acid catabolic process (GO:0043649)2.70963761
96tyrosine metabolic process (GO:0006570)2.70114934
97synaptic vesicle exocytosis (GO:0016079)2.70092247
98regulation of protein activation cascade (GO:2000257)2.68479490
99primary amino compound metabolic process (GO:1901160)2.68039670
100synaptic vesicle maturation (GO:0016188)2.66854203
101cyclic nucleotide catabolic process (GO:0009214)2.66843185
102nitrogen cycle metabolic process (GO:0071941)2.66819684
103gamma-aminobutyric acid transport (GO:0015812)2.66309852
104homocysteine metabolic process (GO:0050667)2.65755232
105regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.62711237
106fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.62497170
107lysine catabolic process (GO:0006554)2.62324933
108lysine metabolic process (GO:0006553)2.62324933
109aspartate family amino acid catabolic process (GO:0009068)2.61959071
110positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.61501302
111pyrimidine nucleobase catabolic process (GO:0006208)2.61338967
112negative regulation of dendrite morphogenesis (GO:0050774)2.61130209
113regulation of glutamate receptor signaling pathway (GO:1900449)2.60629772
114positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.59885068
115membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.59775874
116protein carboxylation (GO:0018214)2.59227898
117peptidyl-glutamic acid carboxylation (GO:0017187)2.59227898
118negative regulation of fibrinolysis (GO:0051918)2.58736656
119gamma-aminobutyric acid signaling pathway (GO:0007214)2.58673530
120positive regulation of sodium ion transport (GO:0010765)2.57792245
121cellular amino acid catabolic process (GO:0009063)2.57279561
122membrane depolarization (GO:0051899)2.57092501
123behavioral response to cocaine (GO:0048148)2.55716383
124neuron-neuron synaptic transmission (GO:0007270)2.55694086
125short-chain fatty acid metabolic process (GO:0046459)2.53733955
126aldehyde catabolic process (GO:0046185)2.53313957
127regulation of excitatory postsynaptic membrane potential (GO:0060079)2.53090671
128female mating behavior (GO:0060180)2.52718362
129tricarboxylic acid cycle (GO:0006099)2.52265545
130regulation of synaptic vesicle exocytosis (GO:2000300)2.52093184
131protein localization to synapse (GO:0035418)2.51979490
132neuronal action potential propagation (GO:0019227)2.51792692
133cardiac muscle cell action potential (GO:0086001)2.51180449
134regulation of postsynaptic membrane potential (GO:0060078)2.50477928
135cellular glucuronidation (GO:0052695)2.49493950
136cardiac muscle contraction (GO:0060048)2.48815784
137G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.48676847
138regulation of activation of Janus kinase activity (GO:0010533)2.48485805
139uronic acid metabolic process (GO:0006063)2.47985535
140glucuronate metabolic process (GO:0019585)2.47985535
141pyridine nucleotide biosynthetic process (GO:0019363)2.47719958
142nicotinamide nucleotide biosynthetic process (GO:0019359)2.47719958
143positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.47609979
144cerebellar granule cell differentiation (GO:0021707)2.47033426
145alpha-linolenic acid metabolic process (GO:0036109)2.46730603
146regulation of glutamate secretion (GO:0014048)2.46565916
147amino-acid betaine metabolic process (GO:0006577)2.46351469
148positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.45818663
149regulation of heart rate by cardiac conduction (GO:0086091)2.45207611
150DNA deamination (GO:0045006)2.44808141
151regulation of complement activation (GO:0030449)2.44744830
152regulation of short-term neuronal synaptic plasticity (GO:0048172)2.44085689
1532-oxoglutarate metabolic process (GO:0006103)2.44013216
154regulation of voltage-gated calcium channel activity (GO:1901385)2.43566043
155regulation of triglyceride catabolic process (GO:0010896)2.42961217
156cardiac muscle cell action potential involved in contraction (GO:0086002)2.42413155
157auditory behavior (GO:0031223)2.42303407
158positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.42159309
159response to pheromone (GO:0019236)2.41366191
160regulation of female receptivity (GO:0045924)2.41358344
161regulation of neurotransmitter uptake (GO:0051580)2.41212249
162benzene-containing compound metabolic process (GO:0042537)2.41048495
163positive regulation of meiosis (GO:0045836)2.40512636
164behavioral defense response (GO:0002209)2.39301836
165behavioral fear response (GO:0001662)2.39301836
166nucleobase catabolic process (GO:0046113)2.38828219
167regulation of potassium ion transmembrane transport (GO:1901379)2.37506962
168regulation of striated muscle contraction (GO:0006942)2.37487140
169negative regulation of response to food (GO:0032096)2.37296702
170negative regulation of appetite (GO:0032099)2.37296702
171cardiac muscle hypertrophy (GO:0003300)2.36054859
172negative regulation of dendrite development (GO:2000171)2.35689944
173negative regulation of heart rate (GO:0010459)2.35323280
174neurotransmitter secretion (GO:0007269)2.33306853
175response to amphetamine (GO:0001975)2.33165818
176positive regulation of sodium ion transmembrane transport (GO:1902307)2.32435644
177regulation of cardiac muscle contraction (GO:0055117)2.32268124
178detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.30681312
179proline transport (GO:0015824)2.30266430
180cellular potassium ion transport (GO:0071804)2.29827837
181potassium ion transmembrane transport (GO:0071805)2.29827837
182urinary tract smooth muscle contraction (GO:0014848)2.28364477
183reflex (GO:0060004)2.28274764

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human4.10761106
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.47070604
3TAF15_26573619_Chip-Seq_HEK293_Human3.06649487
4EGR1_23403033_ChIP-Seq_LIVER_Mouse2.81756871
5EZH2_22144423_ChIP-Seq_EOC_Human2.79578662
6TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.45711159
7ZFP57_27257070_Chip-Seq_ESCs_Mouse2.45598245
8* RXR_22158963_ChIP-Seq_LIVER_Mouse2.39339821
9ZNF274_21170338_ChIP-Seq_K562_Hela2.29222698
10FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.28784681
11IGF1R_20145208_ChIP-Seq_DFB_Human2.24213956
12FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.23308535
13GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.16381806
14SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.12121840
15* LXR_22158963_ChIP-Seq_LIVER_Mouse2.05498504
16POU3F2_20337985_ChIP-ChIP_501MEL_Human2.02736223
17SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.01532853
18P300_19829295_ChIP-Seq_ESCs_Human2.00966751
19CTBP2_25329375_ChIP-Seq_LNCAP_Human1.85829123
20RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.84564723
21* PPARA_22158963_ChIP-Seq_LIVER_Mouse1.82555529
22SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.82247115
23GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.78208290
24SMAD_19615063_ChIP-ChIP_OVARY_Human1.73975118
25* SMAD4_21799915_ChIP-Seq_A2780_Human1.71905208
26JARID2_20064375_ChIP-Seq_MESCs_Mouse1.71561136
27SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.66792630
28CTBP1_25329375_ChIP-Seq_LNCAP_Human1.61233797
29SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.58638985
30SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.55663784
31NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.54796672
32NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.54556107
33IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.54528744
34EED_16625203_ChIP-ChIP_MESCs_Mouse1.54320562
35FLI1_27457419_Chip-Seq_LIVER_Mouse1.53451462
36CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.52514910
37PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.51956588
38VDR_22108803_ChIP-Seq_LS180_Human1.49705823
39BCAT_22108803_ChIP-Seq_LS180_Human1.49414765
40REST_21632747_ChIP-Seq_MESCs_Mouse1.48489177
41SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.48256771
42MTF2_20144788_ChIP-Seq_MESCs_Mouse1.46260052
43EWS_26573619_Chip-Seq_HEK293_Human1.46006183
44PIAS1_25552417_ChIP-Seq_VCAP_Human1.45426777
45ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.44267028
46EZH2_18974828_ChIP-Seq_MESCs_Mouse1.43090106
47RNF2_18974828_ChIP-Seq_MESCs_Mouse1.43090106
48IRF8_22096565_ChIP-ChIP_GC-B_Human1.42689071
49HTT_18923047_ChIP-ChIP_STHdh_Human1.41419201
50JARID2_20075857_ChIP-Seq_MESCs_Mouse1.39713165
51HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.39680478
52ER_23166858_ChIP-Seq_MCF-7_Human1.39236135
53SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.37417396
54SMAD3_21741376_ChIP-Seq_EPCs_Human1.36592454
55PCGF2_27294783_Chip-Seq_ESCs_Mouse1.36379047
56EZH2_27304074_Chip-Seq_ESCs_Mouse1.35767755
57NR3C1_21868756_ChIP-Seq_MCF10A_Human1.35346258
58RNF2_27304074_Chip-Seq_NSC_Mouse1.34714720
59AR_25329375_ChIP-Seq_VCAP_Human1.34189118
60TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.33652356
61POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.33652356
62NANOG_18555785_Chip-Seq_ESCs_Mouse1.32222056
63CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.30980585
64NRF2_20460467_ChIP-Seq_MEFs_Mouse1.30835204
65NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.30835204
66SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.30219850
67FUS_26573619_Chip-Seq_HEK293_Human1.29117415
68P53_22387025_ChIP-Seq_ESCs_Mouse1.28949439
69* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.27923039
70SUZ12_27294783_Chip-Seq_NPCs_Mouse1.26835049
71TOP2B_26459242_ChIP-Seq_MCF-7_Human1.26667196
72OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.24819772
73STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.24598857
74E2F1_18555785_Chip-Seq_ESCs_Mouse1.24589335
75CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.24566433
76AR_21572438_ChIP-Seq_LNCaP_Human1.24109354
77EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.23642295
78BMI1_23680149_ChIP-Seq_NPCS_Mouse1.23239680
79UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.23206359
80MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.22481442
81TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.21089657
82REST_18959480_ChIP-ChIP_MESCs_Mouse1.20544922
83SUZ12_18555785_Chip-Seq_ESCs_Mouse1.20183485
84RUNX1_27457419_Chip-Seq_LIVER_Mouse1.19282064
85CBP_20019798_ChIP-Seq_JUKART_Human1.18915020
86IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.18915020
87STAT3_18555785_Chip-Seq_ESCs_Mouse1.18071305
88EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.17887239
89EZH2_27294783_Chip-Seq_NPCs_Mouse1.16948826
90CMYC_18555785_Chip-Seq_ESCs_Mouse1.16782229
91NFE2_27457419_Chip-Seq_LIVER_Mouse1.15046538
92FLI1_21867929_ChIP-Seq_TH2_Mouse1.14196657
93CBX2_27304074_Chip-Seq_ESCs_Mouse1.13945025
94SOX2_18555785_Chip-Seq_ESCs_Mouse1.13258994
95STAT3_23295773_ChIP-Seq_U87_Human1.12955777
96TP53_22573176_ChIP-Seq_HFKS_Human1.11383021
97BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.10943175
98EZH2_27294783_Chip-Seq_ESCs_Mouse1.10852633
99CDX2_19796622_ChIP-Seq_MESCs_Mouse1.10726324
100PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.10077037
101P300_18555785_Chip-Seq_ESCs_Mouse1.09786771
102SUZ12_27294783_Chip-Seq_ESCs_Mouse1.09657315
103MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.08565693
104SOX2_21211035_ChIP-Seq_LN229_Gbm1.08099122
105TCF4_23295773_ChIP-Seq_U87_Human1.07887964
106TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.07728555
107PCGF2_27294783_Chip-Seq_NPCs_Mouse1.05697519
108NR3C1_23031785_ChIP-Seq_PC12_Mouse1.04964696
109TP53_18474530_ChIP-ChIP_U2OS_Human1.04728694
110SMAD4_21741376_ChIP-Seq_EPCs_Human1.04653824
111EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.04364062
112TAL1_26923725_Chip-Seq_HPCs_Mouse1.03851143
113BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.03263910
114CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.03130866
115TCF4_22108803_ChIP-Seq_LS180_Human1.03002898
116NANOG_19829295_ChIP-Seq_ESCs_Human1.02991769
117PRDM14_20953172_ChIP-Seq_ESCs_Human1.02610918
118PU1_27457419_Chip-Seq_LIVER_Mouse1.02584666
119RNF2_27304074_Chip-Seq_ESCs_Mouse1.02473629
120* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.02072637
121NMYC_18555785_Chip-Seq_ESCs_Mouse1.01276338
122KDM2B_26808549_Chip-Seq_REH_Human1.01170194
123DROSHA_22980978_ChIP-Seq_HELA_Human1.00517418
124* RUNX2_22187159_ChIP-Seq_PCA_Human0.99617448
125EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.99051873
126SMAD1_18555785_Chip-Seq_ESCs_Mouse0.97684580

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system4.44508427
2MP0003880_abnormal_central_pattern3.93380471
3MP0005085_abnormal_gallbladder_physiolo3.91233854
4MP0005360_urolithiasis3.75671546
5MP0005365_abnormal_bile_salt3.54638719
6MP0008875_abnormal_xenobiotic_pharmacok3.52949357
7MP0002876_abnormal_thyroid_physiology2.88094133
8MP0004859_abnormal_synaptic_plasticity2.48529552
9MP0009745_abnormal_behavioral_response2.46667563
10MP0000569_abnormal_digit_pigmentation2.36359511
11MP0009046_muscle_twitch2.35673067
12MP0003195_calcinosis2.26651055
13MP0002837_dystrophic_cardiac_calcinosis2.26187932
14MP0002064_seizures2.22381096
15MP0003635_abnormal_synaptic_transmissio2.20498521
16MP0008877_abnormal_DNA_methylation2.18063317
17MP0010329_abnormal_lipoprotein_level2.16201292
18MP0005423_abnormal_somatic_nervous2.10738733
19MP0001968_abnormal_touch/_nociception2.07546166
20MP0002736_abnormal_nociception_after1.99412835
21MP0005646_abnormal_pituitary_gland1.98209764
22MP0002063_abnormal_learning/memory/cond1.94699291
23MP0002102_abnormal_ear_morphology1.86529101
24MP0001986_abnormal_taste_sensitivity1.85309035
25MP0002822_catalepsy1.85258890
26MP0002638_abnormal_pupillary_reflex1.82931520
27MP0002272_abnormal_nervous_system1.82866653
28MP0004885_abnormal_endolymph1.80784590
29MP0002572_abnormal_emotion/affect_behav1.79380529
30MP0009697_abnormal_copulation1.77641525
31MP0003806_abnormal_nucleotide_metabolis1.77141655
32MP0004084_abnormal_cardiac_muscle1.76928914
33MP0002138_abnormal_hepatobiliary_system1.71752062
34MP0003252_abnormal_bile_duct1.71616962
35* MP0005332_abnormal_amino_acid1.61989959
36MP0001501_abnormal_sleep_pattern1.61093649
37MP0001984_abnormal_olfaction1.60689346
38MP0004510_myositis1.58790602
39MP0000372_irregular_coat_pigmentation1.58708118
40MP0001486_abnormal_startle_reflex1.54412459
41MP0009780_abnormal_chondrocyte_physiolo1.54074468
42MP0003137_abnormal_impulse_conducting1.53255708
43MP0004270_analgesia1.51017948
44MP0003646_muscle_fatigue1.47677281
45MP0003191_abnormal_cellular_cholesterol1.45352848
46MP0003879_abnormal_hair_cell1.45089822
47MP0009840_abnormal_foam_cell1.42935578
48MP0004142_abnormal_muscle_tone1.40026829
49MP0002067_abnormal_sensory_capabilities1.36331867
50MP0006072_abnormal_retinal_apoptosis1.36185249
51MP0002909_abnormal_adrenal_gland1.36143972
52MP0004145_abnormal_muscle_electrophysio1.34059028
53MP0005253_abnormal_eye_physiology1.30480326
54MP0002735_abnormal_chemical_nociception1.27898304
55MP0001440_abnormal_grooming_behavior1.27565235
56MP0002163_abnormal_gland_morphology1.26820200
57MP0005535_abnormal_body_temperature1.26243520
58MP0005084_abnormal_gallbladder_morpholo1.25170813
59MP0005083_abnormal_biliary_tract1.23990683
60MP0002118_abnormal_lipid_homeostasis1.23782315
61MP0006035_abnormal_mitochondrial_morpho1.22666323
62MP0003121_genomic_imprinting1.21578338
63MP0008775_abnormal_heart_ventricle1.21574614
64MP0005174_abnormal_tail_pigmentation1.20825955
65MP0005584_abnormal_enzyme/coenzyme_acti1.19997645
66MP0001485_abnormal_pinna_reflex1.19864765
67MP0005379_endocrine/exocrine_gland_phen1.18451425
68MP0002734_abnormal_mechanical_nocicepti1.18088779
69MP0004130_abnormal_muscle_cell1.16638690
70MP0001764_abnormal_homeostasis1.16397464
71MP0005386_behavior/neurological_phenoty1.15030608
72MP0004924_abnormal_behavior1.15030608
73MP0000631_abnormal_neuroendocrine_gland1.14892724
74MP0001905_abnormal_dopamine_level1.12701273
75MP0006276_abnormal_autonomic_nervous1.12518396
76MP0004043_abnormal_pH_regulation1.11098990
77MP0000778_abnormal_nervous_system1.09699435
78MP0003136_yellow_coat_color1.09109034
79MP0004019_abnormal_vitamin_homeostasis1.08449236
80MP0003690_abnormal_glial_cell1.07731657
81MP0006036_abnormal_mitochondrial_physio1.06991453
82MP0008874_decreased_physiological_sensi1.06761630
83MP0003787_abnormal_imprinting1.06072222
84MP0003283_abnormal_digestive_organ1.05590396
85MP0001529_abnormal_vocalization1.03991940
86MP0001666_abnormal_nutrient_absorption1.03401552
87MP0008872_abnormal_physiological_respon1.03123816
88MP0002693_abnormal_pancreas_physiology1.01890355
89MP0004742_abnormal_vestibular_system1.01542431
90MP0001502_abnormal_circadian_rhythm0.99746641
91MP0005075_abnormal_melanosome_morpholog0.99361241
92MP0004036_abnormal_muscle_relaxation0.98732876
93MP0002254_reproductive_system_inflammat0.97115440
94MP0002229_neurodegeneration0.96707025
95MP0004215_abnormal_myocardial_fiber0.96586285
96MP0009764_decreased_sensitivity_to0.95057546
97MP0003633_abnormal_nervous_system0.94598478
98MP0005319_abnormal_enzyme/_coenzyme0.94574252
99MP0003868_abnormal_feces_composition0.93141623
100MP0003122_maternal_imprinting0.92857576
101MP0000604_amyloidosis0.90210542
102MP0002160_abnormal_reproductive_system0.89713255
103MP0001346_abnormal_lacrimal_gland0.89636197
104MP0005620_abnormal_muscle_contractility0.89017980
105MP0004147_increased_porphyrin_level0.88304113
106MP0001835_abnormal_antigen_presentation0.88126738
107MP0005451_abnormal_body_composition0.87059154
108MP0010386_abnormal_urinary_bladder0.86794963
109MP0003329_amyloid_beta_deposits0.85649235
110MP0003011_delayed_dark_adaptation0.85251964
111MP0005389_reproductive_system_phenotype0.84608950
112MP0001963_abnormal_hearing_physiology0.83849658
113MP0002184_abnormal_innervation0.83194248
114MP0008995_early_reproductive_senescence0.82891707
115MP0000609_abnormal_liver_physiology0.82810867
116MP0002882_abnormal_neuron_morphology0.82662482
117MP0003631_nervous_system_phenotype0.82636555
118MP0001188_hyperpigmentation0.81803580
119MP0002928_abnormal_bile_duct0.80224810
120MP0009785_altered_susceptibility_to0.80118021
121MP0002557_abnormal_social/conspecific_i0.78683772
122MP0004133_heterotaxia0.78538665
123MP0005171_absent_coat_pigmentation0.78425797
124MP0001970_abnormal_pain_threshold0.77981602
125MP0005167_abnormal_blood-brain_barrier0.77359973
126MP0000955_abnormal_spinal_cord0.77048820
127MP0001544_abnormal_cardiovascular_syste0.75201921
128MP0005385_cardiovascular_system_phenoty0.75201921
129MP0003183_abnormal_peptide_metabolism0.74676689
130MP0005310_abnormal_salivary_gland0.73749875
131MP0002066_abnormal_motor_capabilities/c0.73233555
132MP0000749_muscle_degeneration0.72394078
133MP0008569_lethality_at_weaning0.71649211
134MP0002332_abnormal_exercise_endurance0.71486065
135MP0004085_abnormal_heartbeat0.71411460
136MP0002733_abnormal_thermal_nociception0.71090341
137MP0001944_abnormal_pancreas_morphology0.70668001
138MP0000026_abnormal_inner_ear0.70457077
139MP0002078_abnormal_glucose_homeostasis0.69892461
140MP0005551_abnormal_eye_electrophysiolog0.67899454
141MP0000230_abnormal_systemic_arterial0.66869420
142MP0005448_abnormal_energy_balance0.66801005
143MP0002972_abnormal_cardiac_muscle0.66398218
144MP0005645_abnormal_hypothalamus_physiol0.65867685
145MP0004484_altered_response_of0.65688991

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.59453344
2Hyperventilation (HP:0002883)5.39924896
3Prolonged partial thromboplastin time (HP:0003645)4.27294473
4Epileptic encephalopathy (HP:0200134)4.07698269
5Atonic seizures (HP:0010819)3.88490292
6Intrahepatic cholestasis (HP:0001406)3.83648015
7Abnormality of aromatic amino acid family metabolism (HP:0004338)3.78858058
8Febrile seizures (HP:0002373)3.72924573
9Deep venous thrombosis (HP:0002625)3.56156579
10Syncope (HP:0001279)3.55055357
11Progressive cerebellar ataxia (HP:0002073)3.40061462
12Bundle branch block (HP:0011710)3.37956563
13Hypobetalipoproteinemia (HP:0003563)3.35810718
14Cerebral edema (HP:0002181)3.23183910
15Congenital stationary night blindness (HP:0007642)3.18519963
16Acute necrotizing encephalopathy (HP:0006965)3.16019235
17Abnormal mitochondria in muscle tissue (HP:0008316)3.09936791
18Acute encephalopathy (HP:0006846)3.09682484
19Atrial fibrillation (HP:0005110)3.09480917
20Sudden death (HP:0001699)3.09162655
21Joint hemorrhage (HP:0005261)3.07084288
22Hyperlipoproteinemia (HP:0010980)3.06354356
23Limb dystonia (HP:0002451)3.05932182
24Pancreatic cysts (HP:0001737)3.04113419
25Conjugated hyperbilirubinemia (HP:0002908)2.97591643
26Primary atrial arrhythmia (HP:0001692)2.95051387
27Xanthomatosis (HP:0000991)2.91810314
28Fair hair (HP:0002286)2.89465840
29Nephronophthisis (HP:0000090)2.85130829
30Absence seizures (HP:0002121)2.84912806
31Abnormality of monocarboxylic acid metabolism (HP:0010996)2.83253719
32Abnormal hair whorl (HP:0010721)2.82098575
33Progressive macrocephaly (HP:0004481)2.79872077
34Pancreatic fibrosis (HP:0100732)2.79868462
35Supraventricular tachycardia (HP:0004755)2.77940517
36Abnormality of methionine metabolism (HP:0010901)2.77017510
37Abnormality of the renal cortex (HP:0011035)2.75309301
38True hermaphroditism (HP:0010459)2.72025170
39Molar tooth sign on MRI (HP:0002419)2.71998640
40Abnormality of midbrain morphology (HP:0002418)2.71998640
41Complement deficiency (HP:0004431)2.71826317
42Focal seizures (HP:0007359)2.70519141
43Dialeptic seizures (HP:0011146)2.68251922
44Ketosis (HP:0001946)2.65968603
45Supraventricular arrhythmia (HP:0005115)2.65739269
46Mitochondrial inheritance (HP:0001427)2.65106462
47Pheochromocytoma (HP:0002666)2.65045843
48Neuroendocrine neoplasm (HP:0100634)2.62597764
49Hemiparesis (HP:0001269)2.61273481
50Ventricular fibrillation (HP:0001663)2.59804012
51Hepatocellular necrosis (HP:0001404)2.59559415
52Myokymia (HP:0002411)2.58316653
53Prolonged QT interval (HP:0001657)2.57826387
54Type II lissencephaly (HP:0007260)2.57706218
55Hyperammonemia (HP:0001987)2.55590662
56Hepatic necrosis (HP:0002605)2.55240638
57Agitation (HP:0000713)2.54774431
58Hyperglycinemia (HP:0002154)2.54184221
59Increased CSF lactate (HP:0002490)2.53952533
60Abnormality of glycolysis (HP:0004366)2.52118543
61Increased serum pyruvate (HP:0003542)2.52118543
62Generalized tonic-clonic seizures (HP:0002069)2.51780612
63Abnormality of aspartate family amino acid metabolism (HP:0010899)2.49792704
64Epidermoid cyst (HP:0200040)2.48479130
65Blue irides (HP:0000635)2.44761783
66Abnormal EKG (HP:0003115)2.43367997
67Abnormality of the renal medulla (HP:0100957)2.41212097
68Abnormal drinking behavior (HP:0030082)2.40321556
69Polydipsia (HP:0001959)2.40321556
70Fat malabsorption (HP:0002630)2.37248021
71Lethargy (HP:0001254)2.33681891
72Spontaneous abortion (HP:0005268)2.33452084
73Hypolipoproteinemia (HP:0010981)2.33106639
74Drooling (HP:0002307)2.32989063
75Left ventricular hypertrophy (HP:0001712)2.32933897
76Medial flaring of the eyebrow (HP:0010747)2.32801288
77Increased IgM level (HP:0003496)2.32151965
78Genetic anticipation (HP:0003743)2.32133889
79Ketoacidosis (HP:0001993)2.26248317
80Abnormality of glutamine family amino acid metabolism (HP:0010902)2.25234624
81Lactic acidosis (HP:0003128)2.23857351
82Metabolic acidosis (HP:0001942)2.21462043
83Excessive salivation (HP:0003781)2.20752735
84Abnormality of fatty-acid metabolism (HP:0004359)2.18415236
85Status epilepticus (HP:0002133)2.17870737
86Decreased circulating renin level (HP:0003351)2.17535851
87Generalized hypopigmentation of hair (HP:0011358)2.15764966
88Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.15584878
89Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.14876158
90Abnormality of sulfur amino acid metabolism (HP:0004339)2.14809745
91Broad-based gait (HP:0002136)2.14623682
92Abnormal gallbladder morphology (HP:0012437)2.14595279
93Gait imbalance (HP:0002141)2.13968164
94Abnormality of the common coagulation pathway (HP:0010990)2.13794898
95Hyperglycinuria (HP:0003108)2.12144026
96Oligomenorrhea (HP:0000876)2.11758350
97Absent speech (HP:0001344)2.11697146
98Cholecystitis (HP:0001082)2.11657453
99Abnormal gallbladder physiology (HP:0012438)2.11657453
100Abnormality of serum amino acid levels (HP:0003112)2.10420888
101Large for gestational age (HP:0001520)2.10252913
102Methylmalonic acidemia (HP:0002912)2.07895623
103Abnormality of glycine metabolism (HP:0010895)2.06870960
104Abnormality of serine family amino acid metabolism (HP:0010894)2.06870960
105Cholelithiasis (HP:0001081)2.06839311
106Hemiplegia (HP:0002301)2.03641993
107Muscle hypertrophy of the lower extremities (HP:0008968)2.02604414
108Abolished electroretinogram (ERG) (HP:0000550)2.02463281
109Epileptiform EEG discharges (HP:0011182)2.02143183
110Hypochromic microcytic anemia (HP:0004840)2.01902466
111Mitral stenosis (HP:0001718)1.99749616
112Hyperbilirubinemia (HP:0002904)1.99162283
113Clumsiness (HP:0002312)1.97876734
114Congenital sensorineural hearing impairment (HP:0008527)1.97215303
115Inability to walk (HP:0002540)1.95749422
116Ventricular arrhythmia (HP:0004308)1.95607056
117Polyphagia (HP:0002591)1.94946917
118Chronic hepatic failure (HP:0100626)1.93771479
119Protruding tongue (HP:0010808)1.93604744
120Hypoglycemic coma (HP:0001325)1.93201607
121Heart block (HP:0012722)1.92719089
122Poor suck (HP:0002033)1.92389173
123Optic disc pallor (HP:0000543)1.92284935
124Attenuation of retinal blood vessels (HP:0007843)1.91585857
125Systemic lupus erythematosus (HP:0002725)1.91444988
126Gaze-evoked nystagmus (HP:0000640)1.91368925
127Steatorrhea (HP:0002570)1.90633259
128Hypoalphalipoproteinemia (HP:0003233)1.89643005
1293-Methylglutaconic aciduria (HP:0003535)1.88303790
130Abnormality of dicarboxylic acid metabolism (HP:0010995)1.88030527
131Dicarboxylic aciduria (HP:0003215)1.88030527
132Hypothermia (HP:0002045)1.87566842
133Acute hepatic failure (HP:0006554)1.86641601
134Renal cortical cysts (HP:0000803)1.86022731
135Poor eye contact (HP:0000817)1.85322787
136Decreased central vision (HP:0007663)1.83910882
137Anxiety (HP:0000739)1.83760652
138Abnormality of the intrinsic pathway (HP:0010989)1.82943673
139Hypercholesterolemia (HP:0003124)1.82103162
140Thyroiditis (HP:0100646)1.81990060
141Sensorimotor neuropathy (HP:0007141)1.81446513
142Stomach cancer (HP:0012126)1.81445927
143Cerebral hemorrhage (HP:0001342)1.81088372
144Hypsarrhythmia (HP:0002521)1.80386296
145EEG with generalized epileptiform discharges (HP:0011198)1.80269054
146Abnormality of binocular vision (HP:0011514)1.80087092
147Diplopia (HP:0000651)1.80087092
148Calf muscle hypertrophy (HP:0008981)1.80048646
149Congenital primary aphakia (HP:0007707)1.79178486
150Abnormal rod and cone electroretinograms (HP:0008323)1.78885283
151Progressive inability to walk (HP:0002505)1.78589472
152Leukodystrophy (HP:0002415)1.77426978
153Cystic liver disease (HP:0006706)1.76966682
154Male pseudohermaphroditism (HP:0000037)1.76630664
155Impaired social interactions (HP:0000735)1.76370631
156Abnormal social behavior (HP:0012433)1.76370631
157Pachygyria (HP:0001302)1.75983914
158Lissencephaly (HP:0001339)1.75848995
159Furrowed tongue (HP:0000221)1.75523760
160Abnormal eating behavior (HP:0100738)1.74139591
161Aplasia/Hypoplasia of the tibia (HP:0005772)1.72083451
162Dysdiadochokinesis (HP:0002075)1.70918387
163Papilledema (HP:0001085)1.70050177
164Polyuria (HP:0000103)1.69826612
165Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.68711442
166Abnormality of alanine metabolism (HP:0010916)1.68711442
167Hyperalaninemia (HP:0003348)1.68711442
168Nephrogenic diabetes insipidus (HP:0009806)1.68638632
169Action tremor (HP:0002345)1.66834033
170Congenital, generalized hypertrichosis (HP:0004540)1.65578207

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK6.66571799
2FRK5.07879745
3MARK13.14978823
4EPHA42.92090037
5MAP2K72.89404446
6MAP3K122.78980020
7AKT32.72764386
8PRPF4B2.44951074
9MAP3K142.35437135
10DAPK22.32153722
11NTRK32.27695792
12BMPR22.16497632
13PAK32.07228033
14MAP3K42.06038355
15MAP2K42.02718967
16CDK192.01800089
17INSRR2.00299707
18PLK21.99465488
19WNK31.97553536
20CCNB11.92528646
21SIK31.88986232
22ACVR1B1.76799673
23OXSR11.70582219
24MYLK1.64688260
25SGK21.63472615
26BCR1.60960287
27GRK11.59836145
28RIPK41.58093333
29MAP3K131.54945559
30DAPK11.51368803
31BCKDK1.36809398
32MAP4K21.36553161
33WNK41.36242057
34TLK11.34545315
35SGK2231.32945898
36SGK4941.32945898
37ARAF1.30701189
38TNIK1.21694062
39PDK31.18499595
40PDK41.18499595
41CAMKK21.17552632
42OBSCN1.17248818
43PNCK1.14829143
44GRK71.12195861
45FGFR21.10583698
46ITK1.10477414
47GRK51.07660305
48PRKCE1.05597689
49ADRBK21.05514273
50SGK31.04039198
51CAMK2A1.03477202
52PTK2B1.00795575
53PKN10.98089275
54ERBB40.94798453
55STK110.90756944
56PIK3CA0.90577570
57PRKCG0.89873941
58BLK0.88898769
59CAMK2B0.85427148
60MUSK0.84874862
61NUAK10.84166117
62MAPK130.83935423
63UHMK10.83009387
64PINK10.82183669
65EPHA30.81936557
66JAK10.81523906
67ERBB30.76726278
68BRAF0.76451326
69TYK20.76175962
70NEK60.76066363
71MINK10.75406719
72CAMK2G0.75179741
73MAP4K10.75037494
74CSNK1G20.75030929
75PDK20.73973016
76KIT0.73913166
77TEC0.72769174
78TSSK60.71580267
79DYRK20.70502515
80PRKCQ0.69571807
81PRKCH0.69434570
82MAPK70.68781178
83DMPK0.67752728
84MAPK150.65977045
85PAK60.64988436
86BMPR1B0.63978786
87MAPK120.62345415
88TNK20.61361665
89STK240.60139103
90SGK10.60137281
91ZAK0.58015405
92CAMK2D0.57804864
93TXK0.56933017
94DAPK30.55556141
95DYRK1A0.54571468
96PRKD10.53906702
97IKBKE0.53782904
98CDK50.52943724
99STK160.51542084
100CAMK40.50946390
101PRKAA10.50711094
102NLK0.49474898
103STK390.49318935
104FGFR30.47832898
105IKBKB0.47598788
106SYK0.45899099
107CAMKK10.45140051
108FGR0.44557772
109RPS6KA50.44491252
110LYN0.43638843
111ADRBK10.43294015
112NTRK20.42727319
113PRKACA0.42582621
114MAP3K70.42450317
115YES10.42414897
116IRAK10.41545806
117PHKG10.41477391
118PHKG20.41477391
119FES0.41341722
120RPS6KA30.41337779
121NME10.40767325
122TAOK30.40757613
123MAPK40.40744328
124PRKAA20.39214719
125SIK20.39083052
126CDK30.38785774
127MAP2K60.38732548
128CAMK10.36771413
129PDK10.35077484
130PDPK10.34823630
131PRKCZ0.34374909
132IRAK40.32316639
133PRKG10.32160159
134TBK10.31170930
135PRKCA0.30976034
136MAP3K90.29775587
137PRKACG0.29506156
138TIE10.28801108

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004004.47898426
2Primary bile acid biosynthesis_Homo sapiens_hsa001203.29998617
3Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.45624155
4Nicotine addiction_Homo sapiens_hsa050332.25052443
5Arginine biosynthesis_Homo sapiens_hsa002202.25018846
6Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.10899614
7Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.10612109
8Phototransduction_Homo sapiens_hsa047442.09640727
9Collecting duct acid secretion_Homo sapiens_hsa049662.01097931
10Propanoate metabolism_Homo sapiens_hsa006401.89149940
11Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.88910898
12Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.87707100
13Butanoate metabolism_Homo sapiens_hsa006501.87207218
14Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.81823361
15Tryptophan metabolism_Homo sapiens_hsa003801.81706006
16Oxidative phosphorylation_Homo sapiens_hsa001901.78465355
17Maturity onset diabetes of the young_Homo sapiens_hsa049501.78381082
182-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.77615912
19Fatty acid degradation_Homo sapiens_hsa000711.75558535
20Synaptic vesicle cycle_Homo sapiens_hsa047211.74161099
21Peroxisome_Homo sapiens_hsa041461.72442402
22Complement and coagulation cascades_Homo sapiens_hsa046101.63098220
23Nitrogen metabolism_Homo sapiens_hsa009101.62805545
24Fatty acid elongation_Homo sapiens_hsa000621.61674796
25Cocaine addiction_Homo sapiens_hsa050301.60563808
26Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.60197598
27Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.57159412
28Linoleic acid metabolism_Homo sapiens_hsa005911.55293066
29Phenylalanine metabolism_Homo sapiens_hsa003601.52160241
30Pyruvate metabolism_Homo sapiens_hsa006201.51536348
31alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.49194389
32Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.48986311
33Steroid hormone biosynthesis_Homo sapiens_hsa001401.48582690
34Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.44802285
35Gastric acid secretion_Homo sapiens_hsa049711.38535075
36Fatty acid metabolism_Homo sapiens_hsa012121.38311897
37Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.37963916
38Pentose and glucuronate interconversions_Homo sapiens_hsa000401.37436104
39Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.36144594
40cAMP signaling pathway_Homo sapiens_hsa040241.35260135
41Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.33398848
42Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.31145073
43GABAergic synapse_Homo sapiens_hsa047271.28989606
44Ether lipid metabolism_Homo sapiens_hsa005651.23523436
45Morphine addiction_Homo sapiens_hsa050321.22997174
46beta-Alanine metabolism_Homo sapiens_hsa004101.22613995
47Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.21274341
48Dilated cardiomyopathy_Homo sapiens_hsa054141.18041561
49Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.17627526
50Sulfur metabolism_Homo sapiens_hsa009201.17181623
51Histidine metabolism_Homo sapiens_hsa003401.16559208
52Chemical carcinogenesis_Homo sapiens_hsa052041.15698281
53Primary immunodeficiency_Homo sapiens_hsa053401.14514846
54Parkinsons disease_Homo sapiens_hsa050121.13934834
55Tyrosine metabolism_Homo sapiens_hsa003501.13337254
56Allograft rejection_Homo sapiens_hsa053301.10522722
57Dorso-ventral axis formation_Homo sapiens_hsa043201.10058689
58PPAR signaling pathway_Homo sapiens_hsa033201.08856936
59Alzheimers disease_Homo sapiens_hsa050101.05687117
60Retinol metabolism_Homo sapiens_hsa008301.05150833
61Cysteine and methionine metabolism_Homo sapiens_hsa002701.03677197
62Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.01174566
63Carbon metabolism_Homo sapiens_hsa012001.01121632
64Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.00035507
65Circadian entrainment_Homo sapiens_hsa047130.99835443
66Olfactory transduction_Homo sapiens_hsa047400.97132776
67Rheumatoid arthritis_Homo sapiens_hsa053230.97038950
68Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.96240980
69Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.95861223
70cGMP-PKG signaling pathway_Homo sapiens_hsa040220.94900472
71Circadian rhythm_Homo sapiens_hsa047100.92487404
72Staphylococcus aureus infection_Homo sapiens_hsa051500.92155934
73Vascular smooth muscle contraction_Homo sapiens_hsa042700.92050377
74Glutamatergic synapse_Homo sapiens_hsa047240.91117204
75Autoimmune thyroid disease_Homo sapiens_hsa053200.90593541
76Taste transduction_Homo sapiens_hsa047420.90345235
77Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.88029806
78Pancreatic secretion_Homo sapiens_hsa049720.87878838
79Ovarian steroidogenesis_Homo sapiens_hsa049130.87801503
80Bile secretion_Homo sapiens_hsa049760.87005175
81Type I diabetes mellitus_Homo sapiens_hsa049400.86753285
82Carbohydrate digestion and absorption_Homo sapiens_hsa049730.85957338
83Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.82901909
84Vibrio cholerae infection_Homo sapiens_hsa051100.80337462
85Amphetamine addiction_Homo sapiens_hsa050310.80196681
86Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.79877050
87Starch and sucrose metabolism_Homo sapiens_hsa005000.78942931
88Asthma_Homo sapiens_hsa053100.78603517
89Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.77103888
90ABC transporters_Homo sapiens_hsa020100.76648558
91Protein export_Homo sapiens_hsa030600.76635829
92Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.75493199
93Selenocompound metabolism_Homo sapiens_hsa004500.75061078
94Caffeine metabolism_Homo sapiens_hsa002320.74208650
95Graft-versus-host disease_Homo sapiens_hsa053320.73897479
96Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.70292989
97Long-term potentiation_Homo sapiens_hsa047200.68312284
98Biosynthesis of amino acids_Homo sapiens_hsa012300.68140096
99Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.68080016
100Cardiac muscle contraction_Homo sapiens_hsa042600.66099617
101Serotonergic synapse_Homo sapiens_hsa047260.65895630
102Drug metabolism - other enzymes_Homo sapiens_hsa009830.64279683
103Salivary secretion_Homo sapiens_hsa049700.62430242
104Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.61521980
105Calcium signaling pathway_Homo sapiens_hsa040200.61025613
106Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.60164011
107Vitamin B6 metabolism_Homo sapiens_hsa007500.59430454
108Renin secretion_Homo sapiens_hsa049240.57983345
109Intestinal immune network for IgA production_Homo sapiens_hsa046720.56585041
110African trypanosomiasis_Homo sapiens_hsa051430.55692744
111Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.55639424
112Huntingtons disease_Homo sapiens_hsa050160.51786786
113Insulin secretion_Homo sapiens_hsa049110.51584124
114Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.50497065
115Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.49198698
116Dopaminergic synapse_Homo sapiens_hsa047280.49095287
117Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.47965284
118Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.47520405
119Mineral absorption_Homo sapiens_hsa049780.45979084
120SNARE interactions in vesicular transport_Homo sapiens_hsa041300.44525419
121MAPK signaling pathway_Homo sapiens_hsa040100.43138866
122Arginine and proline metabolism_Homo sapiens_hsa003300.42121052
123Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.39470304
124Metabolic pathways_Homo sapiens_hsa011000.39455832
125RNA degradation_Homo sapiens_hsa030180.36458622
126Ras signaling pathway_Homo sapiens_hsa040140.35910456
127Fructose and mannose metabolism_Homo sapiens_hsa000510.32702081
128Vitamin digestion and absorption_Homo sapiens_hsa049770.32438226
129Fatty acid biosynthesis_Homo sapiens_hsa000610.32113349
130Arachidonic acid metabolism_Homo sapiens_hsa005900.31526151
131Thyroid hormone synthesis_Homo sapiens_hsa049180.30858234
132RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.30429144
133Long-term depression_Homo sapiens_hsa047300.29908308
134Glycerolipid metabolism_Homo sapiens_hsa005610.29240123
135Cholinergic synapse_Homo sapiens_hsa047250.29091665
136GnRH signaling pathway_Homo sapiens_hsa049120.29073736
137Aldosterone synthesis and secretion_Homo sapiens_hsa049250.27084862
138Phagosome_Homo sapiens_hsa041450.25607893
139Oxytocin signaling pathway_Homo sapiens_hsa049210.25514330
140Type II diabetes mellitus_Homo sapiens_hsa049300.24024679
141Regulation of autophagy_Homo sapiens_hsa041400.23679853
142Glucagon signaling pathway_Homo sapiens_hsa049220.23585268
143Prion diseases_Homo sapiens_hsa050200.23567647

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