PPM1N

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1photoreceptor cell maintenance (GO:0045494)8.98657065
2photoreceptor cell development (GO:0042461)8.67152828
3detection of light stimulus involved in visual perception (GO:0050908)8.62330732
4detection of light stimulus involved in sensory perception (GO:0050962)8.62330732
5eye photoreceptor cell development (GO:0042462)8.38256355
6GMP metabolic process (GO:0046037)8.27802514
7behavioral response to nicotine (GO:0035095)8.05344686
8phototransduction (GO:0007602)7.59145075
9phototransduction, visible light (GO:0007603)7.56298451
10positive regulation of guanylate cyclase activity (GO:0031284)7.52555429
11detection of visible light (GO:0009584)7.32526586
12detection of light stimulus (GO:0009583)7.24319924
13sulfation (GO:0051923)7.21577457
14regulation of guanylate cyclase activity (GO:0031282)7.12158225
15retinal rod cell development (GO:0046548)7.04692981
16protein-chromophore linkage (GO:0018298)7.01846175
17regulation of glomerulus development (GO:0090192)6.98862650
18cellular response to ATP (GO:0071318)6.90148812
19cell proliferation in forebrain (GO:0021846)6.66782929
20visual perception (GO:0007601)6.29793133
21regulation of cell proliferation involved in kidney development (GO:1901722)6.23916188
22sensory perception of light stimulus (GO:0050953)6.23348459
23positive regulation of fatty acid beta-oxidation (GO:0032000)6.19999353
24cellular response to light stimulus (GO:0071482)6.19984655
25regulation of phospholipid biosynthetic process (GO:0071071)5.81712508
26tooth mineralization (GO:0034505)5.75865889
27opsonization (GO:0008228)5.64869878
28gamma-aminobutyric acid transport (GO:0015812)5.44395607
29water-soluble vitamin biosynthetic process (GO:0042364)5.31930246
30cellular anion homeostasis (GO:0030002)5.30076699
31retina development in camera-type eye (GO:0060041)5.29824660
32regulation of branching involved in salivary gland morphogenesis (GO:0060693)5.27377727
33positive regulation of fatty acid oxidation (GO:0046321)5.27276834
34negative regulation of appetite (GO:0032099)5.14653809
35negative regulation of response to food (GO:0032096)5.14653809
36detection of external stimulus (GO:0009581)5.14377401
37positive regulation of metanephros development (GO:0072216)5.09159546
38detection of abiotic stimulus (GO:0009582)5.05426451
39negative regulation of transcription regulatory region DNA binding (GO:2000678)4.87900706
40regulation of cGMP metabolic process (GO:0030823)4.81961980
41negative regulation of hormone biosynthetic process (GO:0032353)4.76264638
42purine ribonucleoside bisphosphate metabolic process (GO:0034035)4.65409490
433-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)4.65409490
44response to UV-C (GO:0010225)4.58623846
45negative regulation of systemic arterial blood pressure (GO:0003085)4.55958963
46regulation of sequestering of triglyceride (GO:0010889)4.32417501
47epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)4.26807398
48positive regulation of cGMP biosynthetic process (GO:0030828)4.24417105
49otic vesicle formation (GO:0030916)4.21328152
50positive regulation of cAMP-mediated signaling (GO:0043950)4.19355600
51cellular response to radiation (GO:0071478)4.18523041
52regulation of cGMP biosynthetic process (GO:0030826)4.17959832
53pharyngeal system development (GO:0060037)4.16194001
54negative regulation of hormone metabolic process (GO:0032351)4.15114144
55flavonoid metabolic process (GO:0009812)4.13160382
56kynurenine metabolic process (GO:0070189)3.94566743
57regulation of DNA endoreduplication (GO:0032875)3.91403835
58multicellular organismal movement (GO:0050879)3.87614162
59musculoskeletal movement (GO:0050881)3.87614162
60lung morphogenesis (GO:0060425)3.79005781
61positive regulation of cGMP metabolic process (GO:0030825)3.78159320
62negative regulation of platelet activation (GO:0010544)3.74200092
63positive regulation of cardiac muscle cell differentiation (GO:2000727)3.72678701
64transmission of nerve impulse (GO:0019226)3.71061836
65indole-containing compound catabolic process (GO:0042436)3.67176583
66indolalkylamine catabolic process (GO:0046218)3.67176583
67tryptophan catabolic process (GO:0006569)3.67176583
68plasma membrane repair (GO:0001778)3.65143908
69regulation of helicase activity (GO:0051095)3.64853248
70negative regulation of cardiac muscle tissue development (GO:0055026)3.64406476
71cerebellar Purkinje cell differentiation (GO:0021702)3.63670974
72protein polyglutamylation (GO:0018095)3.52492387
73negative regulation of macrophage derived foam cell differentiation (GO:0010745)3.50533163
74protein prenylation (GO:0018342)3.49820616
75prenylation (GO:0097354)3.49820616
76regulation of metanephros development (GO:0072215)3.47366594
77serotonin metabolic process (GO:0042428)3.47196772
78negative regulation of gene silencing (GO:0060969)3.46397932
79detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)3.44725730
80membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.44611257
81purine nucleobase biosynthetic process (GO:0009113)3.44314045
82mitotic metaphase plate congression (GO:0007080)3.44020315
83regulation of transcription regulatory region DNA binding (GO:2000677)3.41814103
84regulation of fatty acid beta-oxidation (GO:0031998)3.36264594
85negative chemotaxis (GO:0050919)3.35763321
86regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.34157246
87nucleobase biosynthetic process (GO:0046112)3.33664342
88regulation of DNA damage checkpoint (GO:2000001)3.31350284
89angiogenesis involved in wound healing (GO:0060055)3.30834244
90nonmotile primary cilium assembly (GO:0035058)3.30630090
91eye photoreceptor cell differentiation (GO:0001754)3.30291279
92photoreceptor cell differentiation (GO:0046530)3.30291279
93regulation of cholesterol storage (GO:0010885)3.29984298
94N-acetylglucosamine metabolic process (GO:0006044)3.27752802
95somite development (GO:0061053)3.26184341
96dentate gyrus development (GO:0021542)3.25285533
97positive regulation of digestive system process (GO:0060456)3.23118465
98positive regulation of protein autophosphorylation (GO:0031954)3.22186719
99adaptation of signaling pathway (GO:0023058)3.21941543
100negative regulation of axon extension involved in axon guidance (GO:0048843)3.19567209
101indolalkylamine metabolic process (GO:0006586)3.18927849
102dorsal/ventral axis specification (GO:0009950)3.18549123
103pituitary gland development (GO:0021983)3.17694392
104regulation of response to food (GO:0032095)3.17113321
105regulation of collateral sprouting (GO:0048670)3.16878171
106embryonic hindlimb morphogenesis (GO:0035116)3.15316939
107positive regulation of gluconeogenesis (GO:0045722)3.15125934
108regulation of appetite (GO:0032098)3.11737628
109receptor guanylyl cyclase signaling pathway (GO:0007168)3.10029791
110ribosome assembly (GO:0042255)3.09939625
111estrogen biosynthetic process (GO:0006703)3.04871078
112GPI anchor metabolic process (GO:0006505)3.03651651
113negative regulation of fibrinolysis (GO:0051918)3.02290900
114ribosome biogenesis (GO:0042254)3.01484686
115indole-containing compound metabolic process (GO:0042430)3.01350711
116positive regulation of glomerulus development (GO:0090193)3.00186195
117regulation of female receptivity (GO:0045924)2.98637168
118organ induction (GO:0001759)2.97191961
119superoxide anion generation (GO:0042554)2.96901907
120primary amino compound metabolic process (GO:1901160)2.96633195
121regulation of posttranscriptional gene silencing (GO:0060147)2.95291907
122regulation of gene silencing by miRNA (GO:0060964)2.95291907
123regulation of gene silencing by RNA (GO:0060966)2.95291907
124gamma-aminobutyric acid signaling pathway (GO:0007214)2.94135731
125postsynaptic membrane organization (GO:0001941)2.90928619
126estrogen metabolic process (GO:0008210)2.88483024
127negative regulation of blood pressure (GO:0045776)2.87947512
128presynaptic membrane organization (GO:0097090)2.87809748
129interferon-gamma secretion (GO:0072643)2.87624782
130tryptophan metabolic process (GO:0006568)2.87044424
131response to inactivity (GO:0014854)2.86793793
132spinal cord motor neuron differentiation (GO:0021522)2.86143840
133proteasome assembly (GO:0043248)2.86036098
134regulation of hippo signaling (GO:0035330)2.85990127
135lateral sprouting from an epithelium (GO:0060601)2.85829976
136response to light stimulus (GO:0009416)2.85191336
137positive regulation of kidney development (GO:0090184)2.81559869
138parturition (GO:0007567)2.81503358
139behavioral response to ethanol (GO:0048149)2.81177951
140peristalsis (GO:0030432)2.81057183
141negative regulation by host of viral transcription (GO:0043922)2.79205681
142reflex (GO:0060004)2.77737854
143forebrain morphogenesis (GO:0048853)2.76884382
144regulation of G-protein coupled receptor protein signaling pathway (GO:0008277)2.76476202
145negative regulation of lipid storage (GO:0010888)2.72531107
146aorta morphogenesis (GO:0035909)2.71936442
147positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.71923236
148regulation of neurotransmitter uptake (GO:0051580)2.70862897
149sensory perception (GO:0007600)2.67919364
150kinetochore assembly (GO:0051382)2.65929834
151post-embryonic morphogenesis (GO:0009886)2.62874153
152rRNA modification (GO:0000154)2.62392079
153DNA deamination (GO:0045006)2.62198275
154formation of translation preinitiation complex (GO:0001731)2.60554831
155DNA replication initiation (GO:0006270)2.60506187
156mitochondrial RNA metabolic process (GO:0000959)2.59459265
157CDP-diacylglycerol metabolic process (GO:0046341)2.58228145
158retina layer formation (GO:0010842)2.56580446
159transcription from mitochondrial promoter (GO:0006390)2.56061023
160ribonucleoprotein complex biogenesis (GO:0022613)2.54920901
161intra-S DNA damage checkpoint (GO:0031573)2.54874256
162short-term memory (GO:0007614)2.53340728
163establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.53324045
164mitochondrion transport along microtubule (GO:0047497)2.53324045
165DNA unwinding involved in DNA replication (GO:0006268)2.51659970
166positive regulation of icosanoid secretion (GO:0032305)2.50879265
167mitochondrial DNA replication (GO:0006264)2.50779574
168CDP-diacylglycerol biosynthetic process (GO:0016024)2.50453260
169metaphase plate congression (GO:0051310)2.50267098
170retina homeostasis (GO:0001895)2.48395520
171regulation of nuclear cell cycle DNA replication (GO:0033262)2.46234822
172pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.45101164
173IMP biosynthetic process (GO:0006188)2.43161681
174folic acid metabolic process (GO:0046655)2.42940263
175ribosomal large subunit biogenesis (GO:0042273)2.39190360
176regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.38084371
177anterior/posterior axis specification, embryo (GO:0008595)2.35877980
178mitochondrial DNA metabolic process (GO:0032042)2.33284180
179spliceosomal snRNP assembly (GO:0000387)2.33266985
180nodal signaling pathway (GO:0038092)2.32237978
181folic acid transport (GO:0015884)2.28533253
182maturation of SSU-rRNA (GO:0030490)2.27244124
183neuron development (GO:0048666)2.27065374
184positive regulation of fatty acid transport (GO:2000193)2.25575937
185protein complex localization (GO:0031503)2.24807600
186anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.24704776
187blastocyst development (GO:0001824)2.23181871
188somatic diversification of immune receptors via somatic mutation (GO:0002566)2.23170945
189somatic hypermutation of immunoglobulin genes (GO:0016446)2.23170945
190positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.22489757
191guanosine-containing compound biosynthetic process (GO:1901070)2.22104143
192negative regulation of mast cell activation (GO:0033004)2.20275832
193mitotic nuclear envelope disassembly (GO:0007077)2.18862985
194positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.18484567
195regulation of rhodopsin mediated signaling pathway (GO:0022400)13.5992941
196rhodopsin mediated signaling pathway (GO:0016056)13.4138478
197retinal cone cell development (GO:0046549)11.5535811

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.58377365
2E2F7_22180533_ChIP-Seq_HELA_Human5.19501964
3STAT6_21828071_ChIP-Seq_BEAS2B_Human4.65693641
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.89514323
5KLF2_18264089_ChIP-ChIP_MESCs_Mouse3.52435715
6KLF5_18264089_ChIP-ChIP_MESCs_Mouse3.52435715
7KLF4_18264089_ChIP-ChIP_MESCs_Mouse3.52435715
8FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.36989558
9POU5F1_18700969_ChIP-ChIP_MESCs_Mouse3.27683907
10E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.27358043
11MYC_19079543_ChIP-ChIP_MESCs_Mouse3.23165192
12EED_16625203_ChIP-ChIP_MESCs_Mouse3.20974952
13NANOG_18700969_ChIP-ChIP_MESCs_Mouse3.13354899
14CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.06508476
15SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.91016691
16MYC_18358816_ChIP-ChIP_MESCs_Mouse2.75213629
17EZH2_27304074_Chip-Seq_ESCs_Mouse2.70434452
18* BMI1_23680149_ChIP-Seq_NPCS_Mouse2.70403753
19JARID2_20064375_ChIP-Seq_MESCs_Mouse2.66001517
20NANOG_18555785_ChIP-Seq_MESCs_Mouse2.58239341
21MYC_19030024_ChIP-ChIP_MESCs_Mouse2.57780112
22NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.46965464
23EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.44205854
24JARID2_20075857_ChIP-Seq_MESCs_Mouse2.41594905
25ETS1_20019798_ChIP-Seq_JURKAT_Human2.40217387
26CBX2_27304074_Chip-Seq_ESCs_Mouse2.37143270
27E2F4_17652178_ChIP-ChIP_JURKAT_Human2.33361753
28CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse2.30784299
29JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.30038807
30RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.29092186
31SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.24533983
32EST1_17652178_ChIP-ChIP_JURKAT_Human2.21467400
33HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.21294445
34MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.20358250
35NELFA_20434984_ChIP-Seq_ESCs_Mouse2.17447811
36IRF1_19129219_ChIP-ChIP_H3396_Human2.12916436
37FOXM1_23109430_ChIP-Seq_U2OS_Human2.09881726
38POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.06272696
39NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.03683821
40ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.02852001
41XRN2_22483619_ChIP-Seq_HELA_Human2.02418524
42TCF3_18692474_ChIP-Seq_MEFs_Mouse2.02288953
43CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.02010603
44ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.98942144
45POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.98595061
46SUZ12_27294783_Chip-Seq_ESCs_Mouse1.93820663
47NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.93310505
48SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.93131581
49SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.92640217
50CREB1_15753290_ChIP-ChIP_HEK293T_Human1.91773964
51KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.89156756
52EZH2_27294783_Chip-Seq_ESCs_Mouse1.88543279
53FUS_26573619_Chip-Seq_HEK293_Human1.88185085
54RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.87160077
55GABP_17652178_ChIP-ChIP_JURKAT_Human1.86004547
56RNF2_27304074_Chip-Seq_ESCs_Mouse1.85869370
57TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.85295917
58EZH2_18974828_ChIP-Seq_MESCs_Mouse1.85047251
59RNF2_18974828_ChIP-Seq_MESCs_Mouse1.85047251
60GBX2_23144817_ChIP-Seq_PC3_Human1.81406926
61TDRD3_21172665_ChIP-Seq_MCF-7_Human1.80871748
62E2F1_18555785_ChIP-Seq_MESCs_Mouse1.80086456
63AUTS2_25519132_ChIP-Seq_293T-REX_Human1.78952892
64SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.78792910
65NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.77373480
66ZFP57_27257070_Chip-Seq_ESCs_Mouse1.75491418
67SOX2_18555785_ChIP-Seq_MESCs_Mouse1.74577152
68SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.74384951
69SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.73540320
70TP53_20018659_ChIP-ChIP_R1E_Mouse1.73294480
71MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.71921280
72DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.71248245
73EWS_26573619_Chip-Seq_HEK293_Human1.70611333
74REST_21632747_ChIP-Seq_MESCs_Mouse1.70497384
75NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.69772018
76RNF2_27304074_Chip-Seq_NSC_Mouse1.68272459
77EGR1_19374776_ChIP-ChIP_THP-1_Human1.65819399
78SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.63667362
79TCF3_18692474_ChIP-Seq_MESCs_Mouse1.63599728
80ZNF274_21170338_ChIP-Seq_K562_Hela1.60329607
81PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.59056385
82POU5F1_16153702_ChIP-ChIP_HESCs_Human1.57074411
83MTF2_20144788_ChIP-Seq_MESCs_Mouse1.56837142
84FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.56426602
85SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.56386922
86RING1B_27294783_Chip-Seq_ESCs_Mouse1.56369201
87MYCN_18555785_ChIP-Seq_MESCs_Mouse1.56345670
88POU5F1_16518401_ChIP-PET_MESCs_Mouse1.54101200
89KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.53839199
90STAT3_1855785_ChIP-Seq_MESCs_Mouse1.53580108
91OCT4_18692474_ChIP-Seq_MEFs_Mouse1.53394291
92SOX2_18692474_ChIP-Seq_MEFs_Mouse1.52539167
93AR_21909140_ChIP-Seq_LNCAP_Human1.52451043
94TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.51089633
95ZNF263_19887448_ChIP-Seq_K562_Human1.50964253
96HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.50322238
97MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.48128893
98VDR_23849224_ChIP-Seq_CD4+_Human1.45225001
99NANOG_18692474_ChIP-Seq_MEFs_Mouse1.44915992
100KAP1_27257070_Chip-Seq_ESCs_Mouse1.44790797
101SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.43687763
102CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.42136061
103CTBP2_25329375_ChIP-Seq_LNCAP_Human1.41791616
104TTF2_22483619_ChIP-Seq_HELA_Human1.39900341
105ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.38405159
106SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.37829880
107NANOG_16153702_ChIP-ChIP_HESCs_Human1.36992435
108NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.35821154
109* YY1_22570637_ChIP-Seq_MALME-3M_Human1.35450231
110NANOG_18692474_ChIP-Seq_MESCs_Mouse1.34064294
111KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.31943313
112PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.31658060
113SALL1_21062744_ChIP-ChIP_HESCs_Human1.31004402
114YY1_21170310_ChIP-Seq_MESCs_Mouse1.30765710
115POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.28417221
116P53_22127205_ChIP-Seq_FIBROBLAST_Human1.25852980
117CBP_20019798_ChIP-Seq_JUKART_Human1.25193789
118IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.25193789
119KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.24373783
120SOX2_18692474_ChIP-Seq_MESCs_Mouse1.24334533
121THAP11_20581084_ChIP-Seq_MESCs_Mouse1.24129797
122ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.21517164
123GABP_19822575_ChIP-Seq_HepG2_Human1.21252866
124EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.17297223
125KDM5A_27292631_Chip-Seq_BREAST_Human1.17047655
126MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.15963633
127DCP1A_22483619_ChIP-Seq_HELA_Human1.15801741
128ELF1_17652178_ChIP-ChIP_JURKAT_Human1.15585334
129YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.15370745
130TOP2B_26459242_ChIP-Seq_MCF-7_Human1.15254972
131PRDM14_20953172_ChIP-Seq_ESCs_Human1.14472636
132P300_19829295_ChIP-Seq_ESCs_Human1.13532548
133DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.12213901
134BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.11902209
135NCOR_22424771_ChIP-Seq_293T_Human1.11293018
136E2F1_21310950_ChIP-Seq_MCF-7_Human1.11144997
137KDM2B_26808549_Chip-Seq_REH_Human1.09637137
138BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.09048923
139VDR_22108803_ChIP-Seq_LS180_Human1.08627485
140CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.08207635
141MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.07605206
142CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.06649826
143SMAD4_21741376_ChIP-Seq_EPCs_Human1.06506868
144SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.06141585
145GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.04965745
146NANOG_16518401_ChIP-PET_MESCs_Mouse1.04937282
147KLF4_18555785_ChIP-Seq_MESCs_Mouse1.04819364
148CTBP1_25329375_ChIP-Seq_LNCAP_Human1.03821447
149AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.02779802
150ER_23166858_ChIP-Seq_MCF-7_Human1.01363303
151NANOG_21062744_ChIP-ChIP_HESCs_Human1.01355811
152LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.01089487
153REST_18959480_ChIP-ChIP_MESCs_Mouse1.00999447
154ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.98962204
155GATA1_26923725_Chip-Seq_HPCs_Mouse0.98392917
156FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.98185836
157TCF4_23295773_ChIP-Seq_U87_Human0.98103400
158UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.97417977
159IGF1R_20145208_ChIP-Seq_DFB_Human0.96598736
160GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.95536618
161SOX2_21211035_ChIP-Seq_LN229_Gbm0.94465695
162TFEB_21752829_ChIP-Seq_HELA_Human0.93787841
163FOXP3_21729870_ChIP-Seq_TREG_Human0.93127658
164RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.92992886
165MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.92785021
166NOTCH1_21737748_ChIP-Seq_TLL_Human0.92035361
167TAL1_26923725_Chip-Seq_HPCs_Mouse0.91895593
168JUN_21703547_ChIP-Seq_K562_Human0.91863598
169TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.91021452
170SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.90809408
171STAT3_23295773_ChIP-Seq_U87_Human0.90393804
172PHF8_20622854_ChIP-Seq_HELA_Human0.90282865
173AHR_22903824_ChIP-Seq_MCF-7_Human0.90102518
174SMAD3_21741376_ChIP-Seq_EPCs_Human0.89278559
175BCAT_22108803_ChIP-Seq_LS180_Human0.87571385
176SOX2_16153702_ChIP-ChIP_HESCs_Human0.87202997
177SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.85418461
178CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.85219869
179GF1_26923725_Chip-Seq_HPCs_Mouse0.84125715
180FOXH1_21741376_ChIP-Seq_ESCs_Human0.84005928
181TP63_19390658_ChIP-ChIP_HaCaT_Human0.83783171
182RING1B_27294783_Chip-Seq_NPCs_Mouse0.82354231
183GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.82300815
184RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.81490325
185TAF15_26573619_Chip-Seq_HEK293_Human0.81151723
186MYC_18940864_ChIP-ChIP_HL60_Human0.81000824
187SMAD4_21799915_ChIP-Seq_A2780_Human0.80944881
188ELK1_22589737_ChIP-Seq_MCF10A_Human0.78676573
189P68_20966046_ChIP-Seq_HELA_Human0.77050716
190TP63_17297297_ChIP-ChIP_HaCaT_Human0.76817680
191E2F1_20622854_ChIP-Seq_HELA_Human0.74372378
192CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.74188334

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003011_delayed_dark_adaptation9.18373200
2MP0005551_abnormal_eye_electrophysiolog8.25784819
3MP0006072_abnormal_retinal_apoptosis6.12180512
4MP0005253_abnormal_eye_physiology5.94120478
5MP0003950_abnormal_plasma_membrane4.52758405
6MP0004134_abnormal_chest_morphology4.01643065
7MP0004145_abnormal_muscle_electrophysio3.96018366
8MP0005195_abnormal_posterior_eye3.30405097
9MP0005391_vision/eye_phenotype3.09346315
10MP0003646_muscle_fatigue3.06158355
11MP0002638_abnormal_pupillary_reflex3.00554789
12MP0001485_abnormal_pinna_reflex2.90746191
13MP0005646_abnormal_pituitary_gland2.85648907
14MP0000049_abnormal_middle_ear2.78578675
15MP0002160_abnormal_reproductive_system2.78341577
16MP0000678_abnormal_parathyroid_gland2.67756217
17MP0001324_abnormal_eye_pigmentation2.62499380
18MP0004130_abnormal_muscle_cell2.51740755
19MP0008057_abnormal_DNA_replication2.48793559
20MP0000631_abnormal_neuroendocrine_gland2.36430379
21MP0002090_abnormal_vision2.34832264
22MP0009250_abnormal_appendicular_skeleto2.33794448
23MP0003693_abnormal_embryo_hatching2.33656620
24MP0009379_abnormal_foot_pigmentation2.10756872
25MP0003195_calcinosis2.08903530
26MP0002653_abnormal_ependyma_morphology2.03914361
27MP0001764_abnormal_homeostasis1.97870449
28MP0002229_neurodegeneration1.95986868
29MP0008872_abnormal_physiological_respon1.93594584
30MP0002876_abnormal_thyroid_physiology1.88067485
31MP0003111_abnormal_nucleus_morphology1.87925080
32MP0002138_abnormal_hepatobiliary_system1.84767883
33MP0002272_abnormal_nervous_system1.81788179
34MP0002089_abnormal_postnatal_growth/wei1.79799244
35MP0002837_dystrophic_cardiac_calcinosis1.79584309
36MP0003879_abnormal_hair_cell1.78688838
37MP0005389_reproductive_system_phenotype1.76946593
38MP0002752_abnormal_somatic_nervous1.74161118
39MP0002249_abnormal_larynx_morphology1.71408879
40MP0001440_abnormal_grooming_behavior1.70192666
41MP0003638_abnormal_response/metabolism_1.69479522
42MP0004957_abnormal_blastocyst_morpholog1.68206787
43MP0004142_abnormal_muscle_tone1.66352124
44MP0010094_abnormal_chromosome_stability1.65616179
45MP0008058_abnormal_DNA_repair1.65308177
46MP0005423_abnormal_somatic_nervous1.63786794
47MP0003880_abnormal_central_pattern1.62219467
48MP0003938_abnormal_ear_development1.61139474
49MP0003077_abnormal_cell_cycle1.61010485
50MP0002733_abnormal_thermal_nociception1.60557013
51MP0009053_abnormal_anal_canal1.55508476
52MP0001853_heart_inflammation1.52960454
53MP0002163_abnormal_gland_morphology1.52480255
54MP0009745_abnormal_behavioral_response1.51777708
55MP0010030_abnormal_orbit_morphology1.47885779
56MP0010352_gastrointestinal_tract_polyps1.44566708
57MP0002332_abnormal_exercise_endurance1.41880038
58MP0009046_muscle_twitch1.36950272
59MP0006292_abnormal_olfactory_placode1.36645932
60MP0004133_heterotaxia1.34416527
61MP0001968_abnormal_touch/_nociception1.32706025
62MP0002064_seizures1.31675805
63MP0001177_atelectasis1.30615587
64MP0002735_abnormal_chemical_nociception1.30349452
65MP0003942_abnormal_urinary_system1.29609752
66MP0000537_abnormal_urethra_morphology1.28384479
67MP0003787_abnormal_imprinting1.25871880
68MP0001970_abnormal_pain_threshold1.25606255
69MP0009780_abnormal_chondrocyte_physiolo1.23376448
70MP0008260_abnormal_autophagy1.18798600
71MP0002184_abnormal_innervation1.18589782
72MP0003937_abnormal_limbs/digits/tail_de1.16491169
73MP0009384_cardiac_valve_regurgitation1.14279223
74MP0004019_abnormal_vitamin_homeostasis1.13045362
75MP0001986_abnormal_taste_sensitivity1.12685180
76MP0002282_abnormal_trachea_morphology1.12342671
77MP0001730_embryonic_growth_arrest1.07917055
78MP0001346_abnormal_lacrimal_gland1.07895983
79MP0002127_abnormal_cardiovascular_syste1.05465500
80MP0001542_abnormal_bone_strength1.04338078
81MP0001188_hyperpigmentation1.03803715
82MP0003890_abnormal_embryonic-extraembry1.03384530
83MP0000613_abnormal_salivary_gland1.03118035
84MP0000350_abnormal_cell_proliferation1.02020912
85MP0004233_abnormal_muscle_weight1.01012872
86MP0004185_abnormal_adipocyte_glucose0.99452390
87MP0005248_abnormal_Harderian_gland0.98789054
88MP0008877_abnormal_DNA_methylation0.98089604
89MP0005076_abnormal_cell_differentiation0.97827141
90MP0002928_abnormal_bile_duct0.97699847
91MP0000681_abnormal_thyroid_gland0.96432497
92MP0001984_abnormal_olfaction0.96204149
93MP0002882_abnormal_neuron_morphology0.95525693
94MP0003635_abnormal_synaptic_transmissio0.94946485
95MP0005379_endocrine/exocrine_gland_phen0.94657357
96MP0005670_abnormal_white_adipose0.93694506
97MP0005084_abnormal_gallbladder_morpholo0.92048433
98MP0010307_abnormal_tumor_latency0.91983990
99MP0004215_abnormal_myocardial_fiber0.91885958
100MP0000733_abnormal_muscle_development0.91292681
101MP0005360_urolithiasis0.88747234
102MP0001486_abnormal_startle_reflex0.88155090
103MP0002557_abnormal_social/conspecific_i0.87223024
104MP0002116_abnormal_craniofacial_bone0.86415801
105MP0005394_taste/olfaction_phenotype0.84562949
106MP0005499_abnormal_olfactory_system0.84562949
107MP0008932_abnormal_embryonic_tissue0.83471820
108MP0005448_abnormal_energy_balance0.82808732
109MP0004742_abnormal_vestibular_system0.81223806
110MP0001293_anophthalmia0.81083684
111MP0002063_abnormal_learning/memory/cond0.79501664
112MP0001919_abnormal_reproductive_system0.78524170
113MP0000778_abnormal_nervous_system0.78130042
114MP0009765_abnormal_xenobiotic_induced0.77712102
115MP0001286_abnormal_eye_development0.77585726
116MP0003936_abnormal_reproductive_system0.76932798
117MP0003221_abnormal_cardiomyocyte_apopto0.76296626
118MP0008007_abnormal_cellular_replicative0.75257148
119MP0000534_abnormal_ureter_morphology0.74040361
120MP0001697_abnormal_embryo_size0.73765771
121MP0003718_maternal_effect0.73139171
122MP0003941_abnormal_skin_development0.72564858
123MP0000230_abnormal_systemic_arterial0.71940923
124MP0006276_abnormal_autonomic_nervous0.71449275
125MP0001905_abnormal_dopamine_level0.70366411
126MP0002572_abnormal_emotion/affect_behav0.70217777
127MP0002932_abnormal_joint_morphology0.69475256
128MP0002139_abnormal_hepatobiliary_system0.68981286
129MP0001502_abnormal_circadian_rhythm0.67668826
130MP0000639_abnormal_adrenal_gland0.67394440
131MP0001672_abnormal_embryogenesis/_devel0.67099534
132MP0005380_embryogenesis_phenotype0.67099534
133MP0009840_abnormal_foam_cell0.66929724
134MP0002085_abnormal_embryonic_tissue0.66926710
135MP0005376_homeostasis/metabolism_phenot0.66878053
136MP0009278_abnormal_bone_marrow0.66635248
137MP0003567_abnormal_fetal_cardiomyocyte0.63396725
138MP0008789_abnormal_olfactory_epithelium0.63181381
139MP0002734_abnormal_mechanical_nocicepti0.60655600
140MP0002277_abnormal_respiratory_mucosa0.60029392
141MP0000358_abnormal_cell_content/0.58371987
142MP0004270_analgesia0.56790794
143MP0000313_abnormal_cell_death0.56751654
144MP0002697_abnormal_eye_size0.56661827
145MP0005266_abnormal_metabolism0.56511694
146MP0002084_abnormal_developmental_patter0.55858856
147MP0003186_abnormal_redox_activity0.53972856
148MP0002080_prenatal_lethality0.53762546
149MP0005197_abnormal_uvea_morphology0.53059104
150MP0002088_abnormal_embryonic_growth/wei0.53040340
151MP0006035_abnormal_mitochondrial_morpho0.52853480
152MP0003123_paternal_imprinting0.52459436
153MP0003634_abnormal_glial_cell0.52311502
154MP0003984_embryonic_growth_retardation0.51720556
155MP0003119_abnormal_digestive_system0.51384378
156MP0002086_abnormal_extraembryonic_tissu0.48361576
157MP0003436_decreased_susceptibility_to0.47556797
158MP0004782_abnormal_surfactant_physiolog0.46902853
159MP0010386_abnormal_urinary_bladder0.46006925
160MP0003136_yellow_coat_color0.45840541
161MP0004885_abnormal_endolymph0.45548303
162MP0005621_abnormal_cell_physiology0.43986048
163MP0002102_abnormal_ear_morphology0.43147189
164MP0002751_abnormal_autonomic_nervous0.42216798
165MP0005384_cellular_phenotype0.41006639
166MP0000858_altered_metastatic_potential0.40099128
167MP0003566_abnormal_cell_adhesion0.38772790
168MP0003448_altered_tumor_morphology0.38318735
169MP0009333_abnormal_splenocyte_physiolog0.37168197
170MP0001963_abnormal_hearing_physiology0.36442188
171MP0004197_abnormal_fetal_growth/weight/0.35593216
172MP0002210_abnormal_sex_determination0.34594394
173MP0002092_abnormal_eye_morphology0.34051826
174MP0001145_abnormal_male_reproductive0.31581392
175MP0003861_abnormal_nervous_system0.30663993
176MP0000026_abnormal_inner_ear0.30324234
177MP0003786_premature_aging0.29171802

Predicted human phenotypes

RankGene SetZ-score
1Absent rod-and cone-mediated responses on ERG (HP:0007688)9.23698613
2Abnormal rod and cone electroretinograms (HP:0008323)8.82810555
3Dyschromatopsia (HP:0007641)8.23023903
4Pigmentary retinal degeneration (HP:0001146)7.87248768
5Attenuation of retinal blood vessels (HP:0007843)7.39007657
6Chorioretinal atrophy (HP:0000533)7.35049194
7Central scotoma (HP:0000603)7.06022104
8Pendular nystagmus (HP:0012043)6.89888777
9Abnormality of macular pigmentation (HP:0008002)6.74839526
10Scotoma (HP:0000575)6.54767294
11Decreased central vision (HP:0007663)6.01871187
12Abolished electroretinogram (ERG) (HP:0000550)6.00305450
13Genetic anticipation (HP:0003743)5.89338609
14Photophobia (HP:0000613)5.31031626
15Agitation (HP:0000713)5.10247210
16Type II diabetes mellitus (HP:0005978)5.04150215
17Keratoconus (HP:0000563)5.00826366
18Increased corneal curvature (HP:0100692)5.00826366
19Cone-rod dystrophy (HP:0000548)4.63505294
20Progressive cerebellar ataxia (HP:0002073)4.58207586
21Macular degeneration (HP:0000608)4.51745939
22Severe visual impairment (HP:0001141)4.39643796
23Visual hallucinations (HP:0002367)4.32764763
24Vitreoretinal degeneration (HP:0000655)4.31251818
25Porencephaly (HP:0002132)4.23361711
26Confusion (HP:0001289)4.19699316
27Choroideremia (HP:0001139)4.16554403
28Posterior subcapsular cataract (HP:0007787)3.93466135
29Retinitis pigmentosa (HP:0000510)3.92805544
30Constricted visual fields (HP:0001133)3.84238275
31Methylmalonic acidemia (HP:0002912)3.56898950
32Asplenia (HP:0001746)3.54618389
33Diplopia (HP:0000651)3.47421661
34Abnormality of binocular vision (HP:0011514)3.47421661
35Aplasia/Hypoplasia of the spleen (HP:0010451)3.29497313
36Abnormality of the middle phalanx of the 5th finger (HP:0004219)3.25072819
37Conjunctival hamartoma (HP:0100780)3.11792050
383-Methylglutaconic aciduria (HP:0003535)3.11345585
39Abnormality of the nasal septum (HP:0000419)3.10585688
40True hermaphroditism (HP:0010459)3.09612309
41Morphological abnormality of the middle ear (HP:0008609)3.07529179
42Hemiplegia (HP:0002301)3.04217263
43Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)3.02395161
44Short 1st metacarpal (HP:0010034)3.02395161
45Abnormality of the phalanges of the 5th finger (HP:0004213)3.00645132
46Abnormality of the proximal phalanges of the hand (HP:0009834)3.00297389
47Progressive visual loss (HP:0000529)2.97357565
48Methylmalonic aciduria (HP:0012120)2.96298039
49Decreased electroretinogram (ERG) amplitude (HP:0000654)2.90798648
50Abnormality of the phalanges of the 2nd finger (HP:0009541)2.89686856
51Restlessness (HP:0000711)2.87004688
52Homocystinuria (HP:0002156)2.80187156
53Abnormality of homocysteine metabolism (HP:0010919)2.80187156
54Short femoral neck (HP:0100864)2.73720328
55Abnormality of the middle phalanges of the toes (HP:0010183)2.69059527
56Abnormality of the 1st metacarpal (HP:0010009)2.64108822
57Short 4th metacarpal (HP:0010044)2.63855565
58Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.63855565
59Congenital sensorineural hearing impairment (HP:0008527)2.62989520
60Myotonia (HP:0002486)2.61229401
61Impaired smooth pursuit (HP:0007772)2.59691840
62Bone cyst (HP:0012062)2.51497159
63Hamartoma of the eye (HP:0010568)2.50763090
64Furrowed tongue (HP:0000221)2.50687606
65Mesomelia (HP:0003027)2.49095894
66Abnormality of ocular smooth pursuit (HP:0000617)2.47863695
67Goiter (HP:0000853)2.47647736
68Abnormality of cochlea (HP:0000375)2.46490779
69Hemiparesis (HP:0001269)2.45155932
70Short hallux (HP:0010109)2.41735929
71Congenital, generalized hypertrichosis (HP:0004540)2.41410160
72Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.35940229
73Optic nerve hypoplasia (HP:0000609)2.35139792
74Subcapsular cataract (HP:0000523)2.34926630
75Optic disc pallor (HP:0000543)2.33596828
76Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.32124092
77Hypoplastic pelvis (HP:0008839)2.31110106
78Abnormality of the renal collecting system (HP:0004742)2.31070604
79Retinal atrophy (HP:0001105)2.31050616
80Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)2.30745794
81Aplasia/Hypoplasia of the hallux (HP:0008362)2.29222991
82Abnormality of secondary sexual hair (HP:0009888)2.28800488
83Abnormality of the axillary hair (HP:0100134)2.28800488
84Short phalanx of the thumb (HP:0009660)2.28724230
85Gaze-evoked nystagmus (HP:0000640)2.26728493
86Synostosis of carpal bones (HP:0005048)2.22896659
87Cystic liver disease (HP:0006706)2.21762799
88Adrenal hypoplasia (HP:0000835)2.21056756
89Breast hypoplasia (HP:0003187)2.20516411
90Abnormality of DNA repair (HP:0003254)2.20499200
91Long nose (HP:0003189)2.18445352
92Septo-optic dysplasia (HP:0100842)2.17201080
93Short tibia (HP:0005736)2.15964674
94Nephronophthisis (HP:0000090)2.15199655
95Small hand (HP:0200055)2.14159989
96Irregular vertebral endplates (HP:0003301)2.13575661
97Symphalangism affecting the phalanges of the hand (HP:0009773)2.13561804
98Stenosis of the external auditory canal (HP:0000402)2.11977694
99Wide nasal bridge (HP:0000431)2.11693441
100Abnormality of the 4th metacarpal (HP:0010012)2.09035799
101Incomplete penetrance (HP:0003829)2.05544130
102Male pseudohermaphroditism (HP:0000037)2.04460151
103Tinnitus (HP:0000360)2.02539409
104Meningioma (HP:0002858)2.01849207
105Aplasia/Hypoplasia of the tibia (HP:0005772)2.01028834
106Congenital stationary night blindness (HP:0007642)13.0092041
107Bony spicule pigmentary retinopathy (HP:0007737)11.0589660
108Aplasia/Hypoplasia involving the pelvis (HP:0009103)1.98350151
109Anxiety (HP:0000739)1.95072414
110Hypoplasia of the uterus (HP:0000013)1.92964119
111Radial bowing (HP:0002986)1.91040353
112Cerebral hypomyelination (HP:0006808)1.89177752
113Truncal obesity (HP:0001956)1.89036111
114Abnormal number of erythroid precursors (HP:0012131)1.88762320
115Colon cancer (HP:0003003)1.88191604
116Abnormality of abdominal situs (HP:0011620)1.88144928
117Abdominal situs inversus (HP:0003363)1.88144928
118Gonadotropin excess (HP:0000837)1.86970226
119Humeroradial synostosis (HP:0003041)1.86826777
120Synostosis involving the elbow (HP:0003938)1.86826777
121Type II lissencephaly (HP:0007260)1.86631088
122Morphological abnormality of the inner ear (HP:0011390)1.86259178
123Birth length less than 3rd percentile (HP:0003561)1.80068559
124Congenital primary aphakia (HP:0007707)1.68339043
125Gait imbalance (HP:0002141)1.68180777
126Horizontal nystagmus (HP:0000666)1.65616795
127Supernumerary spleens (HP:0009799)1.65052819
128Absent radius (HP:0003974)1.63021933
129Optic atrophy (HP:0000648)1.60514091
130Interstitial pulmonary disease (HP:0006530)1.59385271
131Aplasia involving forearm bones (HP:0009822)1.55236560
132Absent forearm bone (HP:0003953)1.55236560
133Carpal bone hypoplasia (HP:0001498)1.53047676
134Agnosia (HP:0010524)1.48952203
135Absent thumb (HP:0009777)1.47158064
136Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.44367107
137Nephrogenic diabetes insipidus (HP:0009806)1.42068343
138Median cleft lip (HP:0000161)1.42007038
139Sclerocornea (HP:0000647)1.41868537
140Increased IgM level (HP:0003496)1.41689258
141Poor coordination (HP:0002370)1.41066914
142Medial flaring of the eyebrow (HP:0010747)1.40335153
143Pancreatic fibrosis (HP:0100732)1.37072874
144Anal stenosis (HP:0002025)1.37060114
145Severe Myopia (HP:0011003)1.36524525
146Abnormality of macrophages (HP:0004311)1.36440271
147Pallor (HP:0000980)1.34603909
148Astigmatism (HP:0000483)1.33120528
149Aplasia/hypoplasia of the humerus (HP:0006507)1.31976914
150Absent septum pellucidum (HP:0001331)1.28500957
151Abnormality of the septum pellucidum (HP:0007375)1.27347857
152Abnormality of the labia minora (HP:0012880)1.27077937
153Urethral obstruction (HP:0000796)1.26433544
154Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.18944774
155Pancreatic cysts (HP:0001737)1.18278344
156Facial cleft (HP:0002006)1.18196437
157Patellar aplasia (HP:0006443)1.15642435
158Hypoplasia of the fovea (HP:0007750)1.14824785
159Aplasia/Hypoplasia of the fovea (HP:0008060)1.14824785
160Aplasia/Hypoplasia of the lens (HP:0008063)1.12373991
161Cellular immunodeficiency (HP:0005374)1.12239082
162Tracheoesophageal fistula (HP:0002575)1.11086681
163Aplasia/Hypoplasia of the macula (HP:0008059)1.10851824
164Ependymoma (HP:0002888)1.10805336
165Chorioretinal coloboma (HP:0000567)1.07041180
166Short humerus (HP:0005792)1.06329410
167Rough bone trabeculation (HP:0100670)1.05455411
168CNS hypomyelination (HP:0003429)1.05184812
169Cleft eyelid (HP:0000625)1.05142648
170Meckel diverticulum (HP:0002245)1.03890186
171Impulsivity (HP:0100710)1.03726328
172Aplasia/Hypoplasia of the patella (HP:0006498)1.03660446
173Abnormality of the ileum (HP:0001549)1.02752302
174Premature ovarian failure (HP:0008209)1.01928846
175Autoimmune thrombocytopenia (HP:0001973)1.01405315
176Horseshoe kidney (HP:0000085)1.00874252
177Tongue fasciculations (HP:0001308)1.00332066
178Prolonged neonatal jaundice (HP:0006579)0.99938769
179Vaginal atresia (HP:0000148)0.99021217
180Oligodactyly (hands) (HP:0001180)0.98895329
181Chromosomal breakage induced by crosslinking agents (HP:0003221)0.98461409
182Abnormality of dental color (HP:0011073)0.98147737
183Rectal fistula (HP:0100590)0.97640265

Predicted kinase interactions (KEA)

RankGene SetZ-score
1GRK16.47223501
2PBK4.83093052
3PRKD24.73115002
4ADRBK24.18788266
5BUB13.73483469
6EPHA23.66712035
7WEE13.65590356
8MAP3K93.28115685
9FRK3.23525284
10PNCK2.76733094
11CDK122.51476122
12TAF12.39265354
13PINK12.29422366
14TAOK32.07752119
15TTK2.06000988
16VRK22.04280487
17AKT32.03402402
18NEK21.94865234
19NEK11.88764904
20PLK41.84397803
21RPS6KA41.84376395
22NUAK11.71155078
23TNIK1.67143989
24PLK11.61280613
25EIF2AK11.55055804
26TSSK61.53582201
27GRK61.52183008
28DYRK31.51918289
29MAP4K21.50296257
30STK38L1.45563084
31PDK21.44549498
32CSNK1G21.37718178
33CASK1.37081274
34BRD41.33696438
35BMPR1B1.33629725
36CDK71.30803166
37DAPK21.29664597
38IRAK21.29309786
39MAP3K101.28297063
40PLK31.25316154
41TIE11.21933946
42CSNK1G31.21636829
43EIF2AK31.19748773
44SRPK11.18819498
45CSNK1G11.18090231
46PRKCG1.17886694
47WNK41.17363725
48ERBB21.16742360
49WNK31.14177879
50STK161.13893745
51MAP3K111.13622176
52TLK11.12706183
53INSRR1.10777037
54AURKA1.08106325
55CDC71.06356233
56ATR1.04273672
57STK41.03240446
58MKNK21.03066286
59CSNK1A1L1.01278638
60RPS6KB21.00263917
61PAK30.99659395
62MAPK130.97108817
63MAPK40.97028443
64VRK10.95229143
65ALK0.94420206
66ADRBK10.90897201
67CHEK10.84594473
68CSNK1A10.84015083
69TXK0.83493928
70MAPKAPK50.83077614
71ICK0.82453885
72CHEK20.82149929
73BTK0.81302198
74IKBKB0.80597887
75SGK20.80511697
76FGR0.80338813
77AKT20.79657700
78BCKDK0.78323220
79EIF2AK20.77729751
80SGK2230.75996081
81SGK4940.75996081
82GRK50.75406630
83PRKD10.73855896
84BCR0.73416506
85PRKCI0.72204261
86GRK70.71973007
87PIM20.71685025
88PRKCH0.71113360
89OXSR10.70693945
90YES10.70604293
91NTRK20.70565794
92PLK20.70148560
93ZAK0.69945960
94NME20.69341930
95CDK20.68956724
96RPS6KA60.67974589
97IGF1R0.67938559
98MAP2K40.67666481
99SGK10.67267381
100ACVR1B0.66256464
101CSNK1D0.65901997
102AURKB0.65820295
103MAP3K60.65578220
104TAOK20.65174345
105PIM10.65050248
106MAP3K40.64961557
107MAPK70.63796606
108CSK0.63585788
109CAMK2A0.63575034
110NTRK30.63557184
111PRKACA0.63225893
112PRKCE0.60632072
113CSNK1E0.59663783
114PTK60.59073143
115RPS6KA50.58010934
116CLK10.56969675
117STK390.55899130
118CDK10.55897382
119TEC0.55479169
120FGFR10.55318745
121BRSK20.55085357
122BLK0.55084097
123MAP3K80.54532842
124MKNK10.54356808
125DAPK30.54356584
126MAPKAPK30.54232541
127MUSK0.54055178
128CSNK2A20.53940856
129RPS6KA20.53432801
130NME10.53255633
131STK110.53249819
132TESK20.53086066
133FGFR20.53073832
134KDR0.53014023
135PRKCA0.52649654
136ITK0.52537344
137MAP2K70.51980877
138BRAF0.51854357
139ATM0.50859639
140CSNK2A10.49912021
141MATK0.49843864
142DYRK1A0.48455056
143PIK3CA0.45854262
144CAMK1D0.45815323
145MAPK120.45773762
146DYRK20.45177366
147RPS6KL10.44775054
148RPS6KC10.44775054
149FLT30.44251035
150CAMK2B0.43939812
151RIPK40.42671537
152STK240.41864967
153IRAK30.39257514
154MAP3K50.39181299
155CAMK10.39025570
156RPS6KB10.38726817
157PHKG10.38371441
158PHKG20.38371441
159DAPK10.38166266
160CDK50.37799726
161MARK30.37739241
162PRKDC0.37315035
163FYN0.36650894
164PRKCZ0.35240857
165PAK40.34939810
166PAK10.34053714
167MTOR0.33870727
168MELK0.33334539
169GSK3B0.33149371
170ABL20.32318696
171STK380.32244657
172MAPK100.31450068
173TBK10.30874552
174CDK40.30667023
175FER0.29902544
176MAP3K140.29545182
177MAPK140.29279344
178MAP2K20.28205865
179CDK60.27450300
180MAPK90.26777209

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005334.00819813
2Sulfur metabolism_Homo sapiens_hsa009202.52480616
3Melanoma_Homo sapiens_hsa052182.23952007
4Oxidative phosphorylation_Homo sapiens_hsa001902.22122265
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.11116787
6Phototransduction_Homo sapiens_hsa0474413.9401379
7DNA replication_Homo sapiens_hsa030301.99830477
8Proteasome_Homo sapiens_hsa030501.98596200
9Mismatch repair_Homo sapiens_hsa034301.98335378
10Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.92823832
11Parkinsons disease_Homo sapiens_hsa050121.92633980
12RNA polymerase_Homo sapiens_hsa030201.92404204
13Maturity onset diabetes of the young_Homo sapiens_hsa049501.84825165
14Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.70805484
15Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.67051027
16Chemical carcinogenesis_Homo sapiens_hsa052041.62711704
17RNA transport_Homo sapiens_hsa030131.57995345
18Tryptophan metabolism_Homo sapiens_hsa003801.56399514
19Taste transduction_Homo sapiens_hsa047421.50664246
20Ribosome_Homo sapiens_hsa030101.48251100
21Spliceosome_Homo sapiens_hsa030401.45497113
22Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.39183242
23Alzheimers disease_Homo sapiens_hsa050101.38799678
24Type II diabetes mellitus_Homo sapiens_hsa049301.35886269
25Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.33052536
26Renin-angiotensin system_Homo sapiens_hsa046141.30756054
27Synaptic vesicle cycle_Homo sapiens_hsa047211.29633655
28Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.27899475
29Pyrimidine metabolism_Homo sapiens_hsa002401.27797223
30Selenocompound metabolism_Homo sapiens_hsa004501.22777559
31Purine metabolism_Homo sapiens_hsa002301.21027172
32Homologous recombination_Homo sapiens_hsa034401.17663635
33Insulin secretion_Homo sapiens_hsa049111.16541109
34Folate biosynthesis_Homo sapiens_hsa007901.16531146
35Nitrogen metabolism_Homo sapiens_hsa009101.15132859
36Long-term depression_Homo sapiens_hsa047301.10885332
37Base excision repair_Homo sapiens_hsa034101.10715946
38Linoleic acid metabolism_Homo sapiens_hsa005911.10634871
39Huntingtons disease_Homo sapiens_hsa050161.07743606
40Circadian entrainment_Homo sapiens_hsa047131.06166051
41Nucleotide excision repair_Homo sapiens_hsa034201.01787514
42Primary immunodeficiency_Homo sapiens_hsa053401.01437814
43Gap junction_Homo sapiens_hsa045401.00481598
44Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.98108598
45One carbon pool by folate_Homo sapiens_hsa006700.95681022
46Fanconi anemia pathway_Homo sapiens_hsa034600.95523566
47Cell cycle_Homo sapiens_hsa041100.95213240
48Intestinal immune network for IgA production_Homo sapiens_hsa046720.95198223
49Fat digestion and absorption_Homo sapiens_hsa049750.95066442
50Fructose and mannose metabolism_Homo sapiens_hsa000510.93828457
51alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.91805530
52Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.89647984
53Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.87197035
54Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.86582929
55Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.84108007
56mRNA surveillance pathway_Homo sapiens_hsa030150.84076199
57RNA degradation_Homo sapiens_hsa030180.81377552
58Systemic lupus erythematosus_Homo sapiens_hsa053220.81091444
59Retinol metabolism_Homo sapiens_hsa008300.80329316
60Cocaine addiction_Homo sapiens_hsa050300.79648679
61Steroid hormone biosynthesis_Homo sapiens_hsa001400.78744196
62Calcium signaling pathway_Homo sapiens_hsa040200.77901569
63Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.77285215
64Protein export_Homo sapiens_hsa030600.77038893
65MAPK signaling pathway_Homo sapiens_hsa040100.76125527
66Basal transcription factors_Homo sapiens_hsa030220.75575525
67Biosynthesis of amino acids_Homo sapiens_hsa012300.74900815
68Drug metabolism - other enzymes_Homo sapiens_hsa009830.74804940
69p53 signaling pathway_Homo sapiens_hsa041150.71494077
70Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.66902612
71Regulation of autophagy_Homo sapiens_hsa041400.65883840
72Olfactory transduction_Homo sapiens_hsa047400.65845837
73Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.65341335
74Renin secretion_Homo sapiens_hsa049240.65125332
75Caffeine metabolism_Homo sapiens_hsa002320.64791454
76cAMP signaling pathway_Homo sapiens_hsa040240.64122594
77Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.62480436
78Epstein-Barr virus infection_Homo sapiens_hsa051690.62438994
79Ras signaling pathway_Homo sapiens_hsa040140.61334696
80Rap1 signaling pathway_Homo sapiens_hsa040150.60015960
81GABAergic synapse_Homo sapiens_hsa047270.57871879
82Sulfur relay system_Homo sapiens_hsa041220.52240205
83Circadian rhythm_Homo sapiens_hsa047100.51482386
84Cysteine and methionine metabolism_Homo sapiens_hsa002700.50629533
85Mineral absorption_Homo sapiens_hsa049780.50328817
86Graft-versus-host disease_Homo sapiens_hsa053320.49508560
87Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.49327130
88Oocyte meiosis_Homo sapiens_hsa041140.48432200
89HIF-1 signaling pathway_Homo sapiens_hsa040660.47694172
90Inositol phosphate metabolism_Homo sapiens_hsa005620.46850778
91Non-homologous end-joining_Homo sapiens_hsa034500.45655230
92Transcriptional misregulation in cancer_Homo sapiens_hsa052020.45469670
93Axon guidance_Homo sapiens_hsa043600.45290430
94Pentose phosphate pathway_Homo sapiens_hsa000300.45151688
95Collecting duct acid secretion_Homo sapiens_hsa049660.44512287
96Adipocytokine signaling pathway_Homo sapiens_hsa049200.43238387
97Herpes simplex infection_Homo sapiens_hsa051680.41536545
98Vascular smooth muscle contraction_Homo sapiens_hsa042700.41162730
99Cholinergic synapse_Homo sapiens_hsa047250.40779530
100Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.39289993
101ECM-receptor interaction_Homo sapiens_hsa045120.39063316
102Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.38875185
103mTOR signaling pathway_Homo sapiens_hsa041500.38489161
104African trypanosomiasis_Homo sapiens_hsa051430.38394114
105Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.37576285
106Glycerophospholipid metabolism_Homo sapiens_hsa005640.37281538
107Starch and sucrose metabolism_Homo sapiens_hsa005000.37095393
108Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.36967661
109Salivary secretion_Homo sapiens_hsa049700.36610833
110Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.36236892
111Vitamin digestion and absorption_Homo sapiens_hsa049770.34761129
112Legionellosis_Homo sapiens_hsa051340.34555573
113Phenylalanine metabolism_Homo sapiens_hsa003600.34409723
114Ether lipid metabolism_Homo sapiens_hsa005650.33982436
115Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.32951399
116Pentose and glucuronate interconversions_Homo sapiens_hsa000400.32700462
117Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.32615167
118PPAR signaling pathway_Homo sapiens_hsa033200.32457013
119Morphine addiction_Homo sapiens_hsa050320.32414131
120Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.32304563
121NOD-like receptor signaling pathway_Homo sapiens_hsa046210.31128075
122RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.31055949
123Peroxisome_Homo sapiens_hsa041460.30323725
124Amphetamine addiction_Homo sapiens_hsa050310.30065798
125Glioma_Homo sapiens_hsa052140.29920600
126Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.29788115
127Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.29298165
128Glutathione metabolism_Homo sapiens_hsa004800.29033279
129Central carbon metabolism in cancer_Homo sapiens_hsa052300.28525651
130beta-Alanine metabolism_Homo sapiens_hsa004100.28352051
131Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.28113974
132Serotonergic synapse_Homo sapiens_hsa047260.26387682
133Glycerolipid metabolism_Homo sapiens_hsa005610.26051686
134Hippo signaling pathway_Homo sapiens_hsa043900.25346380
135Dopaminergic synapse_Homo sapiens_hsa047280.24032341
136Rheumatoid arthritis_Homo sapiens_hsa053230.22075645
137Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.21993322
138Phagosome_Homo sapiens_hsa041450.21531013
139Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.20391564
140Arginine and proline metabolism_Homo sapiens_hsa003300.19959069
141Phosphatidylinositol signaling system_Homo sapiens_hsa040700.19616955
142Hedgehog signaling pathway_Homo sapiens_hsa043400.18847011
143Galactose metabolism_Homo sapiens_hsa000520.18249390
144Tight junction_Homo sapiens_hsa045300.17958204
145Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.13201190
146TGF-beta signaling pathway_Homo sapiens_hsa043500.13157102
147Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.12736474
148Alcoholism_Homo sapiens_hsa050340.09414704
149Type I diabetes mellitus_Homo sapiens_hsa049400.09142622
150Asthma_Homo sapiens_hsa053100.08751352
151TNF signaling pathway_Homo sapiens_hsa046680.08091520
152Nicotine addiction_Homo sapiens_hsa050330.07883647
153Cardiac muscle contraction_Homo sapiens_hsa042600.07509347
154Basal cell carcinoma_Homo sapiens_hsa052170.06817896
155HTLV-I infection_Homo sapiens_hsa051660.06680113
156Salmonella infection_Homo sapiens_hsa051320.06659602
157ABC transporters_Homo sapiens_hsa020100.06215701
158Apoptosis_Homo sapiens_hsa042100.05919878
159Leishmaniasis_Homo sapiens_hsa051400.05541038
160Pathways in cancer_Homo sapiens_hsa052000.05139020
161Wnt signaling pathway_Homo sapiens_hsa043100.04704986
162Glutamatergic synapse_Homo sapiens_hsa047240.04617632
163Thyroid hormone signaling pathway_Homo sapiens_hsa049190.04422506

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