PPOX

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes the penultimate enzyme of heme biosynthesis, which catalyzes the 6-electron oxidation of protoporphyrinogen IX to form protoporphyrin IX. Mutations in this gene cause variegate porphyria, an autosomal dominant disorder of heme metabolism resulting from a deficiency in protoporphyrinogen oxidase, an enzyme located on the inner mitochondrial membrane. Alternatively spliced transcript variants encoding the same protein have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* heme biosynthetic process (GO:0006783)9.81301969
2* porphyrin-containing compound biosynthetic process (GO:0006779)9.58345389
3N-acetylneuraminate metabolic process (GO:0006054)9.03006137
4centriole replication (GO:0007099)8.74941976
5* tetrapyrrole biosynthetic process (GO:0033014)8.70616150
6base-excision repair, AP site formation (GO:0006285)8.08311371
7* heme metabolic process (GO:0042168)7.91049221
8positive regulation of histone deacetylation (GO:0031065)7.78167329
9* porphyrin-containing compound metabolic process (GO:0006778)7.73645078
10cellular extravasation (GO:0045123)7.29908180
11centriole assembly (GO:0098534)7.23927320
12erythrocyte maturation (GO:0043249)7.21077835
13purine deoxyribonucleotide catabolic process (GO:0009155)7.09328636
14regulation of MHC class II biosynthetic process (GO:0045346)6.41807654
15axonemal dynein complex assembly (GO:0070286)6.25579577
16amino sugar catabolic process (GO:0046348)6.10338499
17epithelial cilium movement (GO:0003351)6.07292141
18erythrocyte development (GO:0048821)5.98216803
19disruption of cells of other organism involved in symbiotic interaction (GO:0051818)5.93171149
20killing of cells in other organism involved in symbiotic interaction (GO:0051883)5.93171149
21cilium movement (GO:0003341)5.80764870
22N-acetylglucosamine metabolic process (GO:0006044)5.65564551
23positive regulation of protein deacetylation (GO:0090312)5.64474190
24reactive oxygen species biosynthetic process (GO:1903409)5.58279156
25regulation of chemokine biosynthetic process (GO:0045073)5.49104555
26cilium or flagellum-dependent cell motility (GO:0001539)5.48750688
27response to methylmercury (GO:0051597)5.32456720
28negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)5.30588920
29positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)5.29766307
30response to lead ion (GO:0010288)5.15785478
31positive regulation of chemokine biosynthetic process (GO:0045080)5.14502869
32* tetrapyrrole metabolic process (GO:0033013)5.10578714
33hemoglobin metabolic process (GO:0020027)4.98077472
34negative regulation of growth of symbiont in host (GO:0044130)4.97176189
35negative regulation of growth of symbiont involved in interaction with host (GO:0044146)4.97176189
36modulation of growth of symbiont involved in interaction with host (GO:0044144)4.97176189
37regulation of growth of symbiont in host (GO:0044126)4.97176189
38thalamus development (GO:0021794)4.93151142
39microglial cell activation (GO:0001774)4.91942706
40insulin-like growth factor receptor signaling pathway (GO:0048009)4.74159952
41purine deoxyribonucleotide metabolic process (GO:0009151)4.71353213
42viral transcription (GO:0019083)4.67943248
43DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla4.66303548
44deoxyribonucleotide catabolic process (GO:0009264)4.65951703
45epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.63141116
46ribosomal small subunit assembly (GO:0000028)4.62652090
47embryonic hemopoiesis (GO:0035162)4.52018117
48one-carbon compound transport (GO:0019755)4.51803020
49response to misfolded protein (GO:0051788)4.49946355
50response to insecticide (GO:0017085)4.46763890
51negative regulation of interleukin-2 production (GO:0032703)4.46242662
52erythrocyte differentiation (GO:0030218)4.45745779
53negative regulation of phagocytosis (GO:0050765)4.45655064
54DNA damage response, signal transduction resulting in transcription (GO:0042772)4.45540234
55macrophage chemotaxis (GO:0048246)4.45312547
56neutrophil mediated immunity (GO:0002446)4.39849839
57deoxyribose phosphate catabolic process (GO:0046386)4.39003142
58* pigment biosynthetic process (GO:0046148)4.33845853
59chaperone-mediated protein transport (GO:0072321)4.32393806
60translational termination (GO:0006415)4.29900328
61very-low-density lipoprotein particle assembly (GO:0034379)4.26856881
62cytokinetic process (GO:0032506)4.24823530
63negative regulation of erythrocyte differentiation (GO:0045647)4.20594614
64ventricular system development (GO:0021591)4.11272906
65SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.10111685
66myeloid cell development (GO:0061515)4.04479787
67cotranslational protein targeting to membrane (GO:0006613)4.04294037
68regulation of histone deacetylation (GO:0031063)4.02666495
69motile cilium assembly (GO:0044458)4.00632411
70plasma lipoprotein particle assembly (GO:0034377)4.00239482
71protein targeting to ER (GO:0045047)3.99898702
72axoneme assembly (GO:0035082)3.91562676
73establishment of protein localization to endoplasmic reticulum (GO:0072599)3.80185334
74* pigment metabolic process (GO:0042440)3.77149562
75translational elongation (GO:0006414)3.72645210
76protein localization to endoplasmic reticulum (GO:0070972)3.69397550
77response to oxygen radical (GO:0000305)3.63997593
78cellular response to oxygen radical (GO:0071450)3.60867456
79removal of superoxide radicals (GO:0019430)3.60867456
80cellular response to superoxide (GO:0071451)3.60867456
81behavioral response to nicotine (GO:0035095)3.60411079
82defense response to fungus (GO:0050832)3.60334985
83regulation of helicase activity (GO:0051095)3.59617233
84telomere maintenance via semi-conservative replication (GO:0032201)3.55309102
85regulation of erythrocyte differentiation (GO:0045646)3.55051883
86hydrogen peroxide catabolic process (GO:0042744)3.55010816
87somatic diversification of immunoglobulins (GO:0016445)3.54102123
88UV protection (GO:0009650)3.50500444
892-deoxyribonucleotide metabolic process (GO:0009394)3.50047288
90granulocyte differentiation (GO:0030851)3.46578581
91somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.43660233
92isotype switching (GO:0045190)3.43660233
93somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.43660233
94protein-lipid complex assembly (GO:0065005)3.34348999
95lipopolysaccharide biosynthetic process (GO:0009103)3.33024161
96misfolded or incompletely synthesized protein catabolic process (GO:0006515)3.32803806
97cellular protein complex disassembly (GO:0043624)3.31017079
98nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.30084592
99viral life cycle (GO:0019058)3.29448857
100glucosamine-containing compound metabolic process (GO:1901071)3.27518287
101microtubule depolymerization (GO:0007019)3.27319503
102regulation of fatty acid transport (GO:2000191)3.26816831
103killing of cells of other organism (GO:0031640)3.26608530
104disruption of cells of other organism (GO:0044364)3.26608530
105DNA deamination (GO:0045006)3.24502499
106induction of positive chemotaxis (GO:0050930)3.23393375
107purine-containing compound salvage (GO:0043101)3.22765575
108cellular response to cadmium ion (GO:0071276)3.20857049
109DNA strand elongation involved in DNA replication (GO:0006271)3.19305683
110deoxyribose phosphate metabolic process (GO:0019692)3.18885635
111gas transport (GO:0015669)3.18666780
112myeloid leukocyte mediated immunity (GO:0002444)3.13172686
113DNA strand elongation (GO:0022616)3.13028850
114negative regulation of T cell differentiation in thymus (GO:0033085)3.12254389
115positive regulation of granulocyte differentiation (GO:0030854)3.11624149
116megakaryocyte development (GO:0035855)3.10567487
117* cofactor biosynthetic process (GO:0051188)3.10008524
118somatic recombination of immunoglobulin gene segments (GO:0016447)3.09136562
119mitotic recombination (GO:0006312)3.06306307
120ribosomal small subunit biogenesis (GO:0042274)3.06198252
121platelet formation (GO:0030220)3.06141892
122G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.05819326
123regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.03836613
124protein complex disassembly (GO:0043241)3.03115868
125positive regulation of B cell differentiation (GO:0045579)3.02172520
126protein autoprocessing (GO:0016540)2.98425263
127regulation of cilium movement (GO:0003352)2.98021846
128protein deneddylation (GO:0000338)2.96573705
129positive regulation of erythrocyte differentiation (GO:0045648)2.95532317
130regulation of synapse structural plasticity (GO:0051823)2.94606816
131ncRNA 3-end processing (GO:0043628)2.92850817
132regulation of protein import into nucleus, translocation (GO:0033158)2.92180459
133response to superoxide (GO:0000303)2.92153947
134phosphatidylglycerol biosynthetic process (GO:0006655)2.91200177
135multicellular organismal aging (GO:0010259)2.91147416
136oxygen transport (GO:0015671)2.87828792
137definitive hemopoiesis (GO:0060216)2.87817185
138heme transport (GO:0015886)2.87634589
139primary alcohol catabolic process (GO:0034310)2.87563791
140deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.87157817
141telomere maintenance via recombination (GO:0000722)2.85691009
142macromolecular complex disassembly (GO:0032984)2.82746568
143negative regulation of RNA splicing (GO:0033119)2.82697207
144negative regulation of telomere maintenance (GO:0032205)2.81936049
145DNA replication checkpoint (GO:0000076)2.81914525
146positive regulation of gamma-delta T cell activation (GO:0046645)2.81546808
147protein-cofactor linkage (GO:0018065)2.81079831
148angiotensin maturation (GO:0002003)2.80851023
149translational initiation (GO:0006413)2.79699148
150left/right pattern formation (GO:0060972)2.79664296
151antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.79035896
152antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.79035896
153negative regulation of viral entry into host cell (GO:0046597)2.79015809
154pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.77877333
155deoxyribonucleotide metabolic process (GO:0009262)2.77764921
156peptidyl-histidine modification (GO:0018202)2.76261512
157negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.74885088
158iron-sulfur cluster assembly (GO:0016226)2.73543753
159metallo-sulfur cluster assembly (GO:0031163)2.73543753
160lipopolysaccharide metabolic process (GO:0008653)2.72349128
161DNA replication initiation (GO:0006270)2.71134202
162bicarbonate transport (GO:0015701)2.68341127
163protein targeting to membrane (GO:0006612)2.67405670
164blood coagulation, intrinsic pathway (GO:0007597)2.65410001
165plasma lipoprotein particle organization (GO:0071827)2.64942682
166negative regulation of transcription regulatory region DNA binding (GO:2000678)2.61213723
167antigen processing and presentation of endogenous antigen (GO:0019883)2.61141007
168lysine metabolic process (GO:0006553)2.59073090
169lysine catabolic process (GO:0006554)2.59073090
170regulation of response to osmotic stress (GO:0047484)2.56014170
171negative regulation of mRNA processing (GO:0050686)2.54177176
172histone H3-K4 trimethylation (GO:0080182)2.54029654
173nucleotide-excision repair, DNA gap filling (GO:0006297)2.51780926
174regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.51544195
175response to folic acid (GO:0051593)2.50276895
176telomere maintenance via telomere lengthening (GO:0010833)2.49989446
177nuclear-transcribed mRNA catabolic process (GO:0000956)2.45306996
178pyrimidine dimer repair (GO:0006290)2.44459580
179regulation of DNA endoreduplication (GO:0032875)2.44273005
180positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003572.43924801
1813-UTR-mediated mRNA stabilization (GO:0070935)2.40768024
182L-alpha-amino acid transmembrane transport (GO:1902475)2.37802520
183fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.36395858
184protein-lipid complex subunit organization (GO:0071825)2.35412517
185valine metabolic process (GO:0006573)2.32798434
186* protoporphyrinogen IX metabolic process (GO:0046501)14.1413812
187* protoporphyrinogen IX biosynthetic process (GO:0006782)13.3171223

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.04908013
2* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.80894800
3GATA1_22025678_ChIP-Seq_K562_Human4.41734160
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.88914573
5IKZF1_21737484_ChIP-ChIP_HCT116_Human3.88299829
6SCL_19346495_ChIP-Seq_HPC-7_Human3.57928133
7IGF1R_20145208_ChIP-Seq_DFB_Human3.38538204
8ELF1_17652178_ChIP-ChIP_JURKAT_Human3.10758353
9FOXM1_23109430_ChIP-Seq_U2OS_Human3.00302406
10TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.95433424
11* GATA1_19941827_ChIP-Seq_MEL_Mouse2.83618785
12TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse2.78820940
13* GATA1_19941826_ChIP-Seq_K562_Human2.68717126
14MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.65577002
15SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.64677321
16HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.63575222
17VDR_21846776_ChIP-Seq_THP-1_Human2.60258951
18ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.47018766
19MYC_22102868_ChIP-Seq_BL_Human2.45113519
20NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.41019068
21* GATA1_22383799_ChIP-Seq_G1ME_Mouse2.34098905
22SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.27557276
23TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.23735706
24E2F4_17652178_ChIP-ChIP_JURKAT_Human2.20959872
25BCL6_27268052_Chip-Seq_Bcells_Human2.13060056
26CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.09632951
27FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.07788275
28CIITA_25753668_ChIP-Seq_RAJI_Human2.07150712
29KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse2.06824434
30KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.04867391
31MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.04859460
32CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.00884489
33CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.96379915
34FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.92762386
35ETS1_20019798_ChIP-Seq_JURKAT_Human1.89735535
36MYC_18555785_ChIP-Seq_MESCs_Mouse1.88843940
37THAP11_20581084_ChIP-Seq_MESCs_Mouse1.88750344
38IRF1_19129219_ChIP-ChIP_H3396_Human1.88396475
39EST1_17652178_ChIP-ChIP_JURKAT_Human1.87667329
40JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.87423583
41CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.87345299
42E2F1_20622854_ChIP-Seq_HELA_Human1.85092505
43MYC_18358816_ChIP-ChIP_MESCs_Mouse1.82740292
44ERG_20887958_ChIP-Seq_HPC-7_Mouse1.75295747
45P68_20966046_ChIP-Seq_HELA_Human1.75195655
46RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.74093423
47* YY1_22570637_ChIP-Seq_MALME-3M_Human1.72685248
48SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.70707034
49TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.69691698
50* SRF_21415370_ChIP-Seq_HL-1_Mouse1.66944387
51* PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.63463869
52LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.62305426
53ETV2_25802403_ChIP-Seq_MESCs_Mouse1.61727255
54PHF8_20622854_ChIP-Seq_HELA_Human1.59275627
55* FOXP3_21729870_ChIP-Seq_TREG_Human1.58535814
56HOXB4_20404135_ChIP-ChIP_EML_Mouse1.57836393
57GABP_17652178_ChIP-ChIP_JURKAT_Human1.56643395
58* XRN2_22483619_ChIP-Seq_HELA_Human1.56641689
59* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.56081730
60* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.53644895
61VDR_23849224_ChIP-Seq_CD4+_Human1.52831900
62FOXP1_21924763_ChIP-Seq_HESCs_Human1.51394962
63RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.49138949
64NANOG_20526341_ChIP-Seq_ESCs_Human1.48445418
65NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.47969488
66SMC4_20622854_ChIP-Seq_HELA_Human1.45496152
67* GATA2_19941826_ChIP-Seq_K562_Human1.44710045
68IRF8_22096565_ChIP-ChIP_GC-B_Human1.44181390
69* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.42622767
70THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.41885822
71SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.41444739
72EGR1_23403033_ChIP-Seq_LIVER_Mouse1.39181486
73LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.39135641
74CREB1_15753290_ChIP-ChIP_HEK293T_Human1.38657798
75VDR_24763502_ChIP-Seq_THP-1_Human1.38346452
76ZNF274_21170338_ChIP-Seq_K562_Hela1.38311466
77DCP1A_22483619_ChIP-Seq_HELA_Human1.37361793
78* SA1_27219007_Chip-Seq_Bcells_Human1.36661794
79MYC_19030024_ChIP-ChIP_MESCs_Mouse1.36471428
80CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.36270149
81MAF_26560356_Chip-Seq_TH1_Human1.35159712
82PPARA_22158963_ChIP-Seq_LIVER_Mouse1.35086376
83PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.34790506
84BCOR_27268052_Chip-Seq_Bcells_Human1.34692538
85MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.34380319
86E2F1_21310950_ChIP-Seq_MCF-7_Human1.33253961
87GATA2_22383799_ChIP-Seq_G1ME_Mouse1.33084604
88HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.33014791
89UTX_26944678_Chip-Seq_JUKART_Human1.31914024
90RXR_22158963_ChIP-Seq_LIVER_Mouse1.31141451
91MYC_18940864_ChIP-ChIP_HL60_Human1.31017227
92ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.30229233
93IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.29466800
94* TET1_21451524_ChIP-Seq_MESCs_Mouse1.28458493
95POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.27903602
96CTCF_20526341_ChIP-Seq_ESCs_Human1.26233377
97E2F1_18555785_ChIP-Seq_MESCs_Mouse1.24601720
98RAC3_21632823_ChIP-Seq_H3396_Human1.22076762
99SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.21638659
100YY1_21170310_ChIP-Seq_MESCs_Mouse1.20581351
101GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.20487708
102SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.20018548
103RUNX1_22412390_ChIP-Seq_EML_Mouse1.20003264
104* CTCF_21964334_ChIP-Seq_BJAB-B_Human1.17339726
105E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.16826469
106EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.16747056
107BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.16410571
108NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.16344308
109ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.15979848
110CTCF_27219007_Chip-Seq_ERYTHROID_Human1.15711527
111P300_27268052_Chip-Seq_Bcells_Human1.14175341
112MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.13019334
113ELF1_20517297_ChIP-Seq_JURKAT_Human1.12310851
114GABP_19822575_ChIP-Seq_HepG2_Human1.12094102
115ERA_21632823_ChIP-Seq_H3396_Human1.11698782
116TAF2_19829295_ChIP-Seq_ESCs_Human1.10713533
117ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.10110955
118MYC_19079543_ChIP-ChIP_MESCs_Mouse1.09554855
119RARB_24833708_ChIP-Seq_LIVER_Mouse1.08623075
120GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.08353202
121SRY_22984422_ChIP-ChIP_TESTIS_Rat1.08193856
122AUTS2_25519132_ChIP-Seq_293T-REX_Human1.04715066
123E2F1_17053090_ChIP-ChIP_MCF-7_Human1.04531946
124FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.04519881
125MAF_26560356_Chip-Seq_TH2_Human1.04161187
126* CTCF_21964334_Chip-Seq_Bcells_Human1.03551845
127SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.03411214
128SPI1_23547873_ChIP-Seq_NB4_Human1.03185539
129STAT4_19710469_ChIP-ChIP_TH1__Mouse1.02279065
130TTF2_22483619_ChIP-Seq_HELA_Human1.02144908
131TCF7_22412390_ChIP-Seq_EML_Mouse1.01977788
132YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.01577768
133KDM5A_27292631_Chip-Seq_BREAST_Human1.00735498
134CTCF_27219007_Chip-Seq_Bcells_Human1.00027394
135FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.98976852
136LXR_22292898_ChIP-Seq_THP-1_Human0.97097096
137NANOG_18555785_ChIP-Seq_MESCs_Mouse0.96996525
138* EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.96386256
139* NCOR1_26117541_ChIP-Seq_K562_Human0.96086431
140TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.95986227
141NELFA_20434984_ChIP-Seq_ESCs_Mouse0.95286793
142RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.95118380
143EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.94068077
144* BRD4_27068464_Chip-Seq_AML-cells_Mouse0.93955346
145* SA1_27219007_Chip-Seq_ERYTHROID_Human0.93770720
146DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.92189498
147ZFX_18555785_ChIP-Seq_MESCs_Mouse0.91759586
148E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.90693596
149CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.90222220

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003656_abnormal_erythrocyte_physiolo9.77660077
2MP0004147_increased_porphyrin_level7.84363969
3MP0008961_abnormal_basal_metabolism3.55922923
4MP0005670_abnormal_white_adipose2.94913432
5MP0005083_abnormal_biliary_tract2.67641071
6MP0008995_early_reproductive_senescence2.52380989
7MP0005397_hematopoietic_system_phenotyp2.51792911
8MP0001545_abnormal_hematopoietic_system2.51792911
9MP0002139_abnormal_hepatobiliary_system2.37218777
10MP0003111_abnormal_nucleus_morphology2.28562738
11MP0005636_abnormal_mineral_homeostasis2.21887238
12MP0002396_abnormal_hematopoietic_system2.16040301
13MP0003786_premature_aging1.98535841
14MP0000685_abnormal_immune_system1.98474479
15MP0002132_abnormal_respiratory_system1.94250774
16MP0001502_abnormal_circadian_rhythm1.92774535
17MP0010094_abnormal_chromosome_stability1.91275042
18MP0006036_abnormal_mitochondrial_physio1.90029181
19MP0002398_abnormal_bone_marrow1.77056199
20MP0003693_abnormal_embryo_hatching1.76873905
21MP0008058_abnormal_DNA_repair1.72447074
22MP0005464_abnormal_platelet_physiology1.71645579
23MP0000003_abnormal_adipose_tissue1.70208175
24MP0003011_delayed_dark_adaptation1.69130055
25MP0006054_spinal_hemorrhage1.68249470
26MP0000689_abnormal_spleen_morphology1.64491779
27MP0002822_catalepsy1.63976049
28MP0005365_abnormal_bile_salt1.62204140
29MP0005671_abnormal_response_to1.56534679
30MP0005360_urolithiasis1.55650983
31MP0009333_abnormal_splenocyte_physiolog1.55412406
32MP0002722_abnormal_immune_system1.53825204
33MP0005174_abnormal_tail_pigmentation1.53591156
34MP0003123_paternal_imprinting1.45965150
35MP0003077_abnormal_cell_cycle1.43710493
36MP0008877_abnormal_DNA_methylation1.40201459
37MP0002429_abnormal_blood_cell1.39540993
38MP0004133_heterotaxia1.36068570
39MP0004885_abnormal_endolymph1.34142204
40MP0005377_hearing/vestibular/ear_phenot1.32583188
41MP0003878_abnormal_ear_physiology1.32583188
42MP0008007_abnormal_cellular_replicative1.32076004
43MP0002638_abnormal_pupillary_reflex1.29459420
44MP0001835_abnormal_antigen_presentation1.25616007
45MP0000609_abnormal_liver_physiology1.23443988
46MP0008789_abnormal_olfactory_epithelium1.19541193
47MP0004742_abnormal_vestibular_system1.17917244
48MP0005220_abnormal_exocrine_pancreas1.17515255
49MP0003806_abnormal_nucleotide_metabolis1.17452614
50MP0001764_abnormal_homeostasis1.17318297
51MP0005085_abnormal_gallbladder_physiolo1.17306359
52MP0004043_abnormal_pH_regulation1.15743611
53MP0010329_abnormal_lipoprotein_level1.15513114
54MP0000490_abnormal_crypts_of1.14319725
55MP0000703_abnormal_thymus_morphology1.10457807
56MP0006292_abnormal_olfactory_placode1.10415985
57MP0003787_abnormal_imprinting1.07961480
58MP0000516_abnormal_urinary_system1.07577971
59MP0005367_renal/urinary_system_phenotyp1.07577971
60MP0005025_abnormal_response_to1.07566528
61MP0001968_abnormal_touch/_nociception1.07150220
62MP0001984_abnormal_olfaction1.06987578
63MP0005387_immune_system_phenotype1.06685067
64MP0001790_abnormal_immune_system1.06685067
65MP0005551_abnormal_eye_electrophysiolog1.06668575
66MP0003183_abnormal_peptide_metabolism1.06153571
67MP0009643_abnormal_urine_homeostasis1.05619694
68MP0001529_abnormal_vocalization1.05493635
69MP0000716_abnormal_immune_system1.05484370
70MP0009765_abnormal_xenobiotic_induced1.05482189
71MP0001800_abnormal_humoral_immune1.05320384
72MP0004808_abnormal_hematopoietic_stem1.04409635
73MP0000465_gastrointestinal_hemorrhage1.03594010
74MP0003136_yellow_coat_color1.01273612
75MP0008872_abnormal_physiological_respon1.00954131
76MP0008775_abnormal_heart_ventricle0.99998903
77MP0004142_abnormal_muscle_tone0.99365608
78MP0001853_heart_inflammation0.98299496
79MP0003763_abnormal_thymus_physiology0.96740197
80MP0003252_abnormal_bile_duct0.96692101
81MP0002420_abnormal_adaptive_immunity0.95534920
82MP0003436_decreased_susceptibility_to0.95042543
83MP0003121_genomic_imprinting0.95041289
84MP0005167_abnormal_blood-brain_barrier0.94385976
85MP0003191_abnormal_cellular_cholesterol0.93661024
86MP0006035_abnormal_mitochondrial_morpho0.93636019
87MP0001819_abnormal_immune_cell0.93111592
88MP0009763_increased_sensitivity_to0.92743029
89MP0008875_abnormal_xenobiotic_pharmacok0.92685343
90MP0005394_taste/olfaction_phenotype0.92473629
91MP0005499_abnormal_olfactory_system0.92473629
92MP0005075_abnormal_melanosome_morpholog0.89919730
93MP0005375_adipose_tissue_phenotype0.89031917
94MP0002095_abnormal_skin_pigmentation0.88731239
95MP0000598_abnormal_liver_morphology0.88650214
96MP0000372_irregular_coat_pigmentation0.88128193
97MP0009931_abnormal_skin_appearance0.87474961
98MP0002405_respiratory_system_inflammati0.86283431
99MP0002723_abnormal_immune_serum0.84824972
100MP0009115_abnormal_fat_cell0.84786014
101MP0003186_abnormal_redox_activity0.84558268
102MP0005000_abnormal_immune_tolerance0.84398737
103MP0000313_abnormal_cell_death0.84025320
104MP0008469_abnormal_protein_level0.83024632
105MP0001666_abnormal_nutrient_absorption0.82125723
106MP0002452_abnormal_antigen_presenting0.80293860
107MP0006276_abnormal_autonomic_nervous0.80017042
108MP0002019_abnormal_tumor_incidence0.79518742
109MP0009764_decreased_sensitivity_to0.79334190
110MP0002736_abnormal_nociception_after0.78342223
111MP0005584_abnormal_enzyme/coenzyme_acti0.77626794
112MP0001905_abnormal_dopamine_level0.76172947
113MP0005451_abnormal_body_composition0.76030177
114MP0005319_abnormal_enzyme/_coenzyme0.75040101
115MP0004019_abnormal_vitamin_homeostasis0.72254252
116MP0009785_altered_susceptibility_to0.72106447
117MP0003718_maternal_effect0.71463956
118MP0005501_abnormal_skin_physiology0.71313349
119MP0002419_abnormal_innate_immunity0.71054683
120MP0003724_increased_susceptibility_to0.70620648
121MP0001929_abnormal_gametogenesis0.69721439
122MP0002138_abnormal_hepatobiliary_system0.69466184
123MP0003698_abnormal_male_reproductive0.69463278
124MP0005084_abnormal_gallbladder_morpholo0.69442761
125MP0009278_abnormal_bone_marrow0.68299597
126MP0008770_decreased_survivor_rate0.68048357
127MP0002970_abnormal_white_adipose0.67520650
128MP0009046_muscle_twitch0.67451944
129MP0002928_abnormal_bile_duct0.66507489
130MP0001663_abnormal_digestive_system0.66472092
131MP0000955_abnormal_spinal_cord0.65600824
132MP0009642_abnormal_blood_homeostasis0.65215823
133MP0003866_abnormal_defecation0.64942499
134MP0002160_abnormal_reproductive_system0.64915613
135MP0002653_abnormal_ependyma_morphology0.64847181
136MP0004145_abnormal_muscle_electrophysio0.64444033
137MP0002277_abnormal_respiratory_mucosa0.63711204
138MP0002735_abnormal_chemical_nociception0.63270695
139MP0002135_abnormal_kidney_morphology0.61063438
140MP0009840_abnormal_foam_cell0.59786994
141MP0009379_abnormal_foot_pigmentation0.59451322
142MP0005266_abnormal_metabolism0.59336677
143MP0003868_abnormal_feces_composition0.58924470
144MP0000015_abnormal_ear_pigmentation0.58037492
145MP0001986_abnormal_taste_sensitivity0.58036032
146MP0003172_abnormal_lysosome_physiology0.57961874
147MP0001845_abnormal_inflammatory_respons0.57786167
148MP0005253_abnormal_eye_physiology0.55904634
149MP0008873_increased_physiological_sensi0.55766231
150MP0002210_abnormal_sex_determination0.55326360
151MP0001324_abnormal_eye_pigmentation0.54298150
152MP0008057_abnormal_DNA_replication0.53971631
153MP0005334_abnormal_fat_pad0.53828193
154MP0003567_abnormal_fetal_cardiomyocyte0.53652208
155MP0003195_calcinosis0.51975028
156MP0002272_abnormal_nervous_system0.49308310
157MP0001270_distended_abdomen0.49227091
158MP0005423_abnormal_somatic_nervous0.49068146
159MP0001145_abnormal_male_reproductive0.48568985
160MP0005448_abnormal_energy_balance0.48314662
161MP0002136_abnormal_kidney_physiology0.48250294
162MP0002229_neurodegeneration0.47235108

Predicted human phenotypes

RankGene SetZ-score
1Poikilocytosis (HP:0004447)9.33433054
2Acanthocytosis (HP:0001927)6.72868519
3Reticulocytosis (HP:0001923)6.72810095
4Abnormal number of erythroid precursors (HP:0012131)6.46522883
5Respiratory insufficiency due to defective ciliary clearance (HP:0200073)6.05435059
6Abnormality of cells of the erythroid lineage (HP:0012130)6.00123821
7Hyperbilirubinemia (HP:0002904)5.71002639
8Abnormal respiratory epithelium morphology (HP:0012253)5.55855523
9Abnormal respiratory motile cilium morphology (HP:0005938)5.55855523
10Hypochromic microcytic anemia (HP:0004840)5.50916308
11Abnormal respiratory motile cilium physiology (HP:0012261)5.33980380
12Abnormality of reticulocytes (HP:0004312)5.28974205
13Abnormal ciliary motility (HP:0012262)5.21155554
14Dynein arm defect of respiratory motile cilia (HP:0012255)5.03837310
15Absent/shortened dynein arms (HP:0200106)5.03837310
16Rhinitis (HP:0012384)4.57656224
17Cholelithiasis (HP:0001081)4.44474372
18Paralysis (HP:0003470)4.36462628
19Diaphragmatic weakness (HP:0009113)4.23257538
20Abnormal gallbladder morphology (HP:0012437)4.17437246
21Insomnia (HP:0100785)3.74514838
22Increased hepatocellular lipid droplets (HP:0006565)3.72683243
23Chronic bronchitis (HP:0004469)3.72261830
24Osteomalacia (HP:0002749)3.69458114
25Abnormality of the prostate (HP:0008775)3.53099520
26Lipid accumulation in hepatocytes (HP:0006561)3.48222408
27Petechiae (HP:0000967)3.44559153
28Prolonged bleeding time (HP:0003010)3.43232008
29* Cutaneous photosensitivity (HP:0000992)3.36612694
30Tubulointerstitial nephritis (HP:0001970)3.31419953
31Hypochromic anemia (HP:0001931)3.23577261
32Bronchiectasis (HP:0002110)3.22352374
33Pancreatic fibrosis (HP:0100732)3.21202645
34Macrocytic anemia (HP:0001972)3.19152492
35Medial flaring of the eyebrow (HP:0010747)3.07938348
36Pallor (HP:0000980)3.07278515
37Abnormality of the gallbladder (HP:0005264)3.03460700
38Microcytic anemia (HP:0001935)3.02702542
39Pancreatic cysts (HP:0001737)3.00337922
40Abnormality of the renal medulla (HP:0100957)2.89931255
41Nasal polyposis (HP:0100582)2.88970536
42Molar tooth sign on MRI (HP:0002419)2.88744245
43Abnormality of midbrain morphology (HP:0002418)2.88744245
44True hermaphroditism (HP:0010459)2.85489590
45Polycythemia (HP:0001901)2.84816944
46Epistaxis (HP:0000421)2.84632111
47Occipital encephalocele (HP:0002085)2.82817210
48Nephronophthisis (HP:0000090)2.80549503
49Reticulocytopenia (HP:0001896)2.73265955
50Cystic liver disease (HP:0006706)2.72113553
51Increased serum ferritin (HP:0003281)2.70472690
52Progressive microcephaly (HP:0000253)2.67440409
53Cholecystitis (HP:0001082)2.67097188
54Abnormal gallbladder physiology (HP:0012438)2.67097188
55Renal salt wasting (HP:0000127)2.58315815
56Type II lissencephaly (HP:0007260)2.57931159
57Tubulointerstitial abnormality (HP:0001969)2.57298221
58Hypokalemic alkalosis (HP:0001949)2.55202223
59Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.54513733
60Congenital hepatic fibrosis (HP:0002612)2.51675675
61Cerebral palsy (HP:0100021)2.50986021
62Abnormality of the renal cortex (HP:0011035)2.49749515
63Gait imbalance (HP:0002141)2.42969372
64Abnormality of chloride homeostasis (HP:0011422)2.42808129
65Absent speech (HP:0001344)2.41510646
66Exertional dyspnea (HP:0002875)2.40429162
67Protruding tongue (HP:0010808)2.40153923
68Retinal dysplasia (HP:0007973)2.39035563
69Hepatocellular necrosis (HP:0001404)2.36942483
70Abnormality of iron homeostasis (HP:0011031)2.36785424
71Hepatic necrosis (HP:0002605)2.33789193
72Congenital primary aphakia (HP:0007707)2.32738637
73Purpura (HP:0000979)2.32708991
74Abnormality of the nasal mucosa (HP:0000433)2.31991696
75Nephrogenic diabetes insipidus (HP:0009806)2.31615302
76Hyponatremia (HP:0002902)2.31447514
77Postaxial foot polydactyly (HP:0001830)2.28992464
78Nonimmune hydrops fetalis (HP:0001790)2.27376397
79Prolonged partial thromboplastin time (HP:0003645)2.22892128
80Aplastic anemia (HP:0001915)2.21840122
81Ileus (HP:0002595)2.21720594
82Lissencephaly (HP:0001339)2.21531049
83Abnormality of transition element cation homeostasis (HP:0011030)2.21258358
84Tubular atrophy (HP:0000092)2.19929749
85Abnormality of renal resorption (HP:0011038)2.19459895
86Chronic otitis media (HP:0000389)2.19308979
87Renal tubular acidosis (HP:0001947)2.18465160
88Respiratory difficulties (HP:0002880)2.14871285
89Anencephaly (HP:0002323)2.13552725
90Abnormality of male internal genitalia (HP:0000022)2.12860657
91Asplenia (HP:0001746)2.11015179
92Hyperglycinemia (HP:0002154)2.10972308
93Impaired platelet aggregation (HP:0003540)2.10010452
94Abnormal platelet function (HP:0011869)2.10010452
95Tubulointerstitial fibrosis (HP:0005576)2.09837580
96Seborrheic dermatitis (HP:0001051)2.09404259
97Obstructive lung disease (HP:0006536)2.09120325
98Chronic obstructive pulmonary disease (HP:0006510)2.09120325
99Chest pain (HP:0100749)2.09086791
100Increased CSF lactate (HP:0002490)2.08852225
101Microvesicular hepatic steatosis (HP:0001414)2.08799876
102Urticaria (HP:0001025)2.08372542
103Sclerocornea (HP:0000647)2.08363297
104Generalized aminoaciduria (HP:0002909)2.07047348
105Aplasia/Hypoplasia of the spleen (HP:0010451)2.04879390
106Polyuria (HP:0000103)2.02543308
107Chronic sinusitis (HP:0011109)2.02186720
108Nausea (HP:0002018)2.01305713
109Neoplasm of the adrenal cortex (HP:0100641)2.00380227
110Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.00275601
111Abnormality of the heme biosynthetic pathway (HP:0010472)13.1716291
112Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.99881826
113Abnormality of sodium homeostasis (HP:0010931)1.99359024
114Hyperaldosteronism (HP:0000859)1.96466614
115Decreased central vision (HP:0007663)1.93781156
116Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.92382429
117Infertility (HP:0000789)1.92136881
118Thrombocytosis (HP:0001894)1.91983998
119Type I transferrin isoform profile (HP:0003642)1.91259106
120Colon cancer (HP:0003003)1.89688134
121Hepatocellular carcinoma (HP:0001402)1.89350099
122Absent rod-and cone-mediated responses on ERG (HP:0007688)1.88346529
123Panhypogammaglobulinemia (HP:0003139)1.86721899
124Renal tubular dysfunction (HP:0000124)1.85916617
125Aplasia/Hypoplasia of the sacrum (HP:0008517)1.84079696
126Abnormal rod and cone electroretinograms (HP:0008323)1.83746372
127Birth length less than 3rd percentile (HP:0003561)1.82290773
128Bronchitis (HP:0012387)1.82130666
129Porencephaly (HP:0002132)1.80854065
130Hypertensive crisis (HP:0100735)1.79490056
131Menorrhagia (HP:0000132)1.79477658
132Aplasia/Hypoplasia of the uvula (HP:0010293)1.78175207
133Brushfield spots (HP:0001088)1.77584970
134Joint hemorrhage (HP:0005261)1.77501809
135Metabolic alkalosis (HP:0200114)1.77438287
136Abnormality of aromatic amino acid family metabolism (HP:0004338)1.77403491
137Confusion (HP:0001289)1.77157977
138Hypoglycemic coma (HP:0001325)1.77053670
139Exercise intolerance (HP:0003546)1.76911110
140Broad distal phalanx of finger (HP:0009836)1.75736738
141Vaginal atresia (HP:0000148)1.75618312
142Ureteral stenosis (HP:0000071)1.75467574
143Broad palm (HP:0001169)1.75166350
144Mitochondrial inheritance (HP:0001427)1.75158274
145Acute lymphatic leukemia (HP:0006721)1.73416551
146Severe global developmental delay (HP:0011344)1.73360305
147Increased serum lactate (HP:0002151)1.71323576
148Pathologic fracture (HP:0002756)1.70347818
149Retinitis pigmentosa (HP:0000510)1.69187975
150Poor coordination (HP:0002370)1.68199014
151Metabolic acidosis (HP:0001942)1.67553746
152Hypertriglyceridemia (HP:0002155)1.64042507
153IgM deficiency (HP:0002850)1.60846606
154Pustule (HP:0200039)1.60839807
155Limb hypertonia (HP:0002509)1.59824252
156Renal Fanconi syndrome (HP:0001994)1.59410632
157Reduced antithrombin III activity (HP:0001976)1.59188276
158Abnormality of the fingertips (HP:0001211)1.58501398
159Increased intramyocellular lipid droplets (HP:0012240)1.58119619
160Pancreatic islet-cell hyperplasia (HP:0004510)1.57520248
161Thrombophlebitis (HP:0004418)1.56419723
162Global brain atrophy (HP:0002283)1.56137399
163Increased muscle lipid content (HP:0009058)1.54659913
164Hyperacusis (HP:0010780)1.53129384
165Neoplasm of head and neck (HP:0012288)1.52975358
166Esophageal neoplasm (HP:0100751)1.52975358
167Recurrent sinusitis (HP:0011108)1.52712986
168Onycholysis (HP:0001806)1.51932401
169Neutropenia (HP:0001875)1.51713210
170Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.51439924
171Decreased activity of mitochondrial respiratory chain (HP:0008972)1.51439924
172Broad face (HP:0000283)1.50942872
173Hypercholesterolemia (HP:0003124)1.50696389
174Abnormality of the pancreatic islet cells (HP:0006476)1.50352059
175Abnormality of endocrine pancreas physiology (HP:0012093)1.50352059
176Short middle phalanx of the 5th finger (HP:0004220)1.49406683
177Conjugated hyperbilirubinemia (HP:0002908)1.48745518
178Colitis (HP:0002583)1.47483798
179Oral leukoplakia (HP:0002745)1.47240811
180Elevated erythrocyte sedimentation rate (HP:0003565)1.46744172

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK24.38002983
2TLK14.25941666
3CAMKK24.17396052
4CAMK1D3.34493178
5SMG13.02504802
6EIF2AK13.00971700
7VRK12.97463926
8NME22.71512703
9TAF12.56767456
10EEF2K2.56075705
11MAP4K12.39955261
12STK162.22909490
13DYRK32.19978101
14MAP3K102.08693740
15MAPK151.99802207
16CAMK1G1.98694639
17TAOK31.97425354
18WNK41.96580147
19NUAK11.89150537
20MAP3K71.84892720
21BCKDK1.81147926
22PRPF4B1.73364797
23FLT31.71940520
24MAP4K21.70746823
25STK101.68308513
26MAPK111.62500785
27BRSK11.59718244
28CAMKK11.57520794
29BTK1.56766206
30TGFBR21.56028714
31SYK1.55240699
32MAPKAPK51.48934367
33ERN11.46093188
34DYRK21.36844506
35SIK11.35012197
36KIT1.33767873
37SIK21.30946560
38GRK61.30600231
39STK41.30076105
40MAPKAPK31.29279211
41TYK21.28662462
42CHUK1.19964139
43IRAK41.19447631
44MAP3K111.14548122
45BRD41.13307052
46TESK11.12984089
47SRPK11.12728272
48NEK21.12500167
49BUB11.12261399
50TNIK1.11663240
51MARK21.11142988
52CDC71.10292050
53CAMK11.10178876
54CDK191.03898530
55LYN1.02650381
56WEE11.01181828
57BRSK20.93570819
58IRAK30.93453426
59GRK50.90458793
60RPS6KA50.88581074
61CSF1R0.87022100
62JAK30.86860604
63TBK10.85619805
64JAK20.84461150
65TEC0.83821928
66MAP3K40.81619162
67CLK10.80392548
68TAOK20.80059473
69MAPK130.79002674
70BLK0.78850012
71CDC42BPA0.78659209
72ZAP700.78030142
73TIE10.76821781
74PIM10.76233712
75DYRK1B0.74667497
76IKBKB0.74051039
77CSNK1G30.73960446
78MAP2K30.73812822
79YES10.73789323
80MKNK20.73190108
81ATR0.72949501
82CDK40.72044436
83IKBKE0.71189279
84PIM20.70871548
85HIPK20.68536395
86AURKB0.68016023
87TESK20.67671625
88LRRK20.67597928
89KDR0.66818690
90INSRR0.66767261
91CCNB10.66663786
92AURKA0.66568939
93ITK0.66095604
94LCK0.63839003
95RPS6KC10.63686648
96RPS6KL10.63686648
97BRAF0.63367618
98RPS6KB20.63354207
99RPS6KA60.62531587
100MAPK120.62113671
101CDK70.60506068
102GRK70.58488494
103MAP2K20.57952484
104CSNK1A1L0.57423827
105RPS6KA20.55231077
106FES0.54724970
107ABL20.53192577
108CSNK1G20.52544462
109MAP2K70.52349201
110TXK0.51440988
111MAPKAPK20.50751876
112CHEK20.50072867
113NME10.49938757
114ACVR1B0.49265626
115CASK0.48442424
116PRKAA20.48373026
117ZAK0.47507024
118CDK80.44180993
119ERBB20.44031889
120TRIB30.43966755
121TRPM70.42648403
122MAP3K80.42059344
123UHMK10.42044584
124TNK20.41442842
125ATM0.40222416
126DAPK10.39761756
127GRK10.39277479
128MAPK30.38620936
129CAMK40.36775439
130PKN20.36733123
131CSNK1G10.35717665
132PRKCQ0.35352043
133CDK90.35331164
134PRKCI0.33757802
135MKNK10.33651374
136DYRK1A0.32332775
137LIMK10.32160714
138MAPK40.30115130
139ICK0.28608619
140CSK0.28560649
141PKN10.21368229
142MAPK90.17773999
143PTK2B0.16843207
144PRKCA0.16774999
145MARK30.16431828
146PRKAA10.16125316
147ADRBK20.15238613
148PRKCD0.14908794
149WNK10.14180429
150PRKACA0.13211409
151CSNK2A10.13073099
152PINK10.12953731
153DAPK30.12340188
154PRKD10.12195190
155WNK30.10311242

Predicted pathways (KEGG)

RankGene SetZ-score
1* Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008605.79819035
2DNA replication_Homo sapiens_hsa030303.92512822
3Ribosome_Homo sapiens_hsa030103.77475654
4Sulfur relay system_Homo sapiens_hsa041223.56696236
5Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005203.03516595
6Base excision repair_Homo sapiens_hsa034102.73950768
7Mismatch repair_Homo sapiens_hsa034302.70801160
8Homologous recombination_Homo sapiens_hsa034402.51635080
9Systemic lupus erythematosus_Homo sapiens_hsa053222.41230331
10Nucleotide excision repair_Homo sapiens_hsa034202.21797666
11ABC transporters_Homo sapiens_hsa020102.10029923
12Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.92170368
13Maturity onset diabetes of the young_Homo sapiens_hsa049501.91547935
14Vitamin B6 metabolism_Homo sapiens_hsa007501.90739833
15Spliceosome_Homo sapiens_hsa030401.86789067
16Protein export_Homo sapiens_hsa030601.82124298
17Fanconi anemia pathway_Homo sapiens_hsa034601.78891391
18One carbon pool by folate_Homo sapiens_hsa006701.71617221
19Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.70853488
20Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.69176005
21Caffeine metabolism_Homo sapiens_hsa002321.68077506
22Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.62022791
23Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.57737811
24Renin-angiotensin system_Homo sapiens_hsa046141.56749094
25Hematopoietic cell lineage_Homo sapiens_hsa046401.52371784
26Phenylalanine metabolism_Homo sapiens_hsa003601.49153997
27Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.47211814
28Fatty acid degradation_Homo sapiens_hsa000711.44421118
29Folate biosynthesis_Homo sapiens_hsa007901.42242115
30Pyrimidine metabolism_Homo sapiens_hsa002401.41236247
31Primary immunodeficiency_Homo sapiens_hsa053401.37941210
32Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.37636640
33RNA polymerase_Homo sapiens_hsa030201.34647353
34Non-homologous end-joining_Homo sapiens_hsa034501.31748169
35Cell cycle_Homo sapiens_hsa041101.30382659
36Lysine degradation_Homo sapiens_hsa003101.28195559
37Linoleic acid metabolism_Homo sapiens_hsa005911.27796526
38Nicotine addiction_Homo sapiens_hsa050331.25627281
39Chemical carcinogenesis_Homo sapiens_hsa052041.22519716
40Basal transcription factors_Homo sapiens_hsa030221.22080338
41Primary bile acid biosynthesis_Homo sapiens_hsa001201.20278230
42Nitrogen metabolism_Homo sapiens_hsa009101.19723568
43Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.14312104
44Complement and coagulation cascades_Homo sapiens_hsa046101.12935915
45Peroxisome_Homo sapiens_hsa041461.11521878
46Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.04431781
47Synaptic vesicle cycle_Homo sapiens_hsa047211.04208892
48Alcoholism_Homo sapiens_hsa050340.98873280
49Cardiac muscle contraction_Homo sapiens_hsa042600.97661550
50Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.97368190
51Selenocompound metabolism_Homo sapiens_hsa004500.96768003
52Parkinsons disease_Homo sapiens_hsa050120.94937995
53Other glycan degradation_Homo sapiens_hsa005110.94210574
54Herpes simplex infection_Homo sapiens_hsa051680.93064001
55Fatty acid metabolism_Homo sapiens_hsa012120.87831325
56Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.86336943
57Oxidative phosphorylation_Homo sapiens_hsa001900.86168081
58Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.85437561
59beta-Alanine metabolism_Homo sapiens_hsa004100.82760923
60alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.79306479
61Tryptophan metabolism_Homo sapiens_hsa003800.79036971
62Arachidonic acid metabolism_Homo sapiens_hsa005900.78121695
63Drug metabolism - other enzymes_Homo sapiens_hsa009830.77572795
64Pyruvate metabolism_Homo sapiens_hsa006200.76812932
65Fatty acid elongation_Homo sapiens_hsa000620.72210591
66Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.71788422
67Pentose phosphate pathway_Homo sapiens_hsa000300.71252029
68Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.71087570
69Glutathione metabolism_Homo sapiens_hsa004800.70247232
70N-Glycan biosynthesis_Homo sapiens_hsa005100.68101062
71Transcriptional misregulation in cancer_Homo sapiens_hsa052020.68087791
72Bladder cancer_Homo sapiens_hsa052190.67115408
73Staphylococcus aureus infection_Homo sapiens_hsa051500.66112867
74Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.65064369
75Malaria_Homo sapiens_hsa051440.64901218
762-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.64356179
77Retinol metabolism_Homo sapiens_hsa008300.62042622
78Cyanoamino acid metabolism_Homo sapiens_hsa004600.60824850
79Biosynthesis of amino acids_Homo sapiens_hsa012300.60597724
80Steroid hormone biosynthesis_Homo sapiens_hsa001400.60535705
81Histidine metabolism_Homo sapiens_hsa003400.58913803
82* Metabolic pathways_Homo sapiens_hsa011000.57557414
83B cell receptor signaling pathway_Homo sapiens_hsa046620.56927858
84Taste transduction_Homo sapiens_hsa047420.56885531
85Cysteine and methionine metabolism_Homo sapiens_hsa002700.56784740
86Measles_Homo sapiens_hsa051620.55561002
87Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.54860344
88Olfactory transduction_Homo sapiens_hsa047400.53076191
89Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.52355843
90Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.52231117
91Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.52006198
92Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.51913801
93Starch and sucrose metabolism_Homo sapiens_hsa005000.51570349
94Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.51379316
95Purine metabolism_Homo sapiens_hsa002300.50560190
96PPAR signaling pathway_Homo sapiens_hsa033200.50248023
97Glycerophospholipid metabolism_Homo sapiens_hsa005640.49536086
98Antigen processing and presentation_Homo sapiens_hsa046120.48108024
99RNA degradation_Homo sapiens_hsa030180.47864962
100Glycerolipid metabolism_Homo sapiens_hsa005610.47339395
101Phagosome_Homo sapiens_hsa041450.46179016
102Fat digestion and absorption_Homo sapiens_hsa049750.45548941
103Carbon metabolism_Homo sapiens_hsa012000.44895089
104Hedgehog signaling pathway_Homo sapiens_hsa043400.44483694
105Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.43542966
106p53 signaling pathway_Homo sapiens_hsa041150.43374215
107Collecting duct acid secretion_Homo sapiens_hsa049660.42944128
108Glycosaminoglycan degradation_Homo sapiens_hsa005310.42028378
109Tyrosine metabolism_Homo sapiens_hsa003500.41701611
110Propanoate metabolism_Homo sapiens_hsa006400.41647972
111Lysosome_Homo sapiens_hsa041420.41382051
112Carbohydrate digestion and absorption_Homo sapiens_hsa049730.41344821
113Huntingtons disease_Homo sapiens_hsa050160.40161689
114Alzheimers disease_Homo sapiens_hsa050100.39847582
115Arginine and proline metabolism_Homo sapiens_hsa003300.39771836
116Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.39449319
117Arginine biosynthesis_Homo sapiens_hsa002200.38771743
118Regulation of autophagy_Homo sapiens_hsa041400.38446394
119Ether lipid metabolism_Homo sapiens_hsa005650.37959601
120Ovarian steroidogenesis_Homo sapiens_hsa049130.37383589
121Asthma_Homo sapiens_hsa053100.36666112
122Proteasome_Homo sapiens_hsa030500.34831956
123Rheumatoid arthritis_Homo sapiens_hsa053230.32750338
124Sulfur metabolism_Homo sapiens_hsa009200.32376184
125Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.31805623
126Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.30183756
127Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.29070569
128Fructose and mannose metabolism_Homo sapiens_hsa000510.28748147
129Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.28622875
130Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.28489872
131SNARE interactions in vesicular transport_Homo sapiens_hsa041300.28396498
132NF-kappa B signaling pathway_Homo sapiens_hsa040640.28279373
133Phototransduction_Homo sapiens_hsa047440.26588619
134Acute myeloid leukemia_Homo sapiens_hsa052210.24764330
135Hepatitis B_Homo sapiens_hsa051610.24530102
136Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.24513114
137Galactose metabolism_Homo sapiens_hsa000520.23362743
138Viral carcinogenesis_Homo sapiens_hsa052030.23277447
139Butanoate metabolism_Homo sapiens_hsa006500.22654748
140Non-small cell lung cancer_Homo sapiens_hsa052230.22139445
141Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.21760063

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