PPP1CA

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is one of the three catalytic subunits of protein phosphatase 1 (PP1). PP1 is a serine/threonine specific protein phosphatase known to be involved in the regulation of a variety of cellular processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viral transcription. Increased PP1 activity has been observed in the end stage of heart failure. Studies in both human and mice suggest that PP1 is an important regulator of cardiac function. Mouse studies also suggest that PP1 functions as a suppressor of learning and memory. Three alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)5.03996770
2DNA strand elongation involved in DNA replication (GO:0006271)4.97027046
3DNA strand elongation (GO:0022616)4.72014864
4telomere maintenance via semi-conservative replication (GO:0032201)4.66003414
5DNA unwinding involved in DNA replication (GO:0006268)4.48546950
6DNA deamination (GO:0045006)4.28731984
7formation of translation preinitiation complex (GO:0001731)4.27330579
8telomere maintenance via recombination (GO:0000722)4.13348521
9DNA replication initiation (GO:0006270)4.01781805
10viral transcription (GO:0019083)3.93085263
11mitotic recombination (GO:0006312)3.87723495
12translational termination (GO:0006415)3.82987292
13protein localization to kinetochore (GO:0034501)3.75607419
14antigen processing and presentation of endogenous antigen (GO:0019883)3.74583912
15maturation of SSU-rRNA (GO:0030490)3.73450664
16positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.69474299
17translational elongation (GO:0006414)3.67878342
18telomere maintenance via telomere lengthening (GO:0010833)3.62390836
19negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.58428813
20cytidine deamination (GO:0009972)3.57207276
21cytidine metabolic process (GO:0046087)3.57207276
22cytidine catabolic process (GO:0006216)3.57207276
23protein maturation by protein folding (GO:0022417)3.56296328
24positive regulation of gamma-delta T cell activation (GO:0046645)3.56204160
25deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.55690391
26immunoglobulin mediated immune response (GO:0016064)3.55688143
27SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.55629450
28nucleotide-excision repair, DNA gap filling (GO:0006297)3.55047797
29DNA replication checkpoint (GO:0000076)3.49820593
30cotranslational protein targeting to membrane (GO:0006613)3.44028765
31nucleobase biosynthetic process (GO:0046112)3.43584009
32protein targeting to ER (GO:0045047)3.43154586
33translational initiation (GO:0006413)3.40917196
34positive thymic T cell selection (GO:0045059)3.40416731
35anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.36947669
36regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.36303283
37positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.35283125
38IMP biosynthetic process (GO:0006188)3.34389256
39ribosomal small subunit biogenesis (GO:0042274)3.30604876
40folic acid-containing compound biosynthetic process (GO:0009396)3.30576566
41negative regulation of ligase activity (GO:0051352)3.28685976
42negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.28685976
43regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.28115983
44antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.27078200
45Arp2/3 complex-mediated actin nucleation (GO:0034314)3.26672959
46antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.26064391
47proteasome assembly (GO:0043248)3.25763250
48DNA replication-dependent nucleosome organization (GO:0034723)3.25197280
49DNA replication-dependent nucleosome assembly (GO:0006335)3.25197280
50positive regulation of B cell differentiation (GO:0045579)3.24169582
51establishment of protein localization to endoplasmic reticulum (GO:0072599)3.23557726
52protein localization to endoplasmic reticulum (GO:0070972)3.23311536
53nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.21995503
54CENP-A containing nucleosome assembly (GO:0034080)3.21471879
55protein localization to chromosome, centromeric region (GO:0071459)3.20679536
56mitotic nuclear envelope disassembly (GO:0007077)3.20372830
57DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.17670951
58signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.15017441
59intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.15017441
60B cell mediated immunity (GO:0019724)3.14723949
61antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.14579658
62purine nucleobase biosynthetic process (GO:0009113)3.14381934
63viral life cycle (GO:0019058)3.10697591
64signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.10400699
65signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.10400699
66signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.10400699
67chromatin remodeling at centromere (GO:0031055)3.08806363
68cellular protein complex disassembly (GO:0043624)3.06485823
69signal transduction involved in DNA damage checkpoint (GO:0072422)3.06300130
70signal transduction involved in DNA integrity checkpoint (GO:0072401)3.06300130
71purine deoxyribonucleotide catabolic process (GO:0009155)3.05903240
72GDP-mannose metabolic process (GO:0019673)3.05133662
73actin nucleation (GO:0045010)3.03907060
74regulation of B cell receptor signaling pathway (GO:0050855)3.03188767
75thymic T cell selection (GO:0045061)3.03058725
76pyrimidine ribonucleoside catabolic process (GO:0046133)3.02069668
77ribosomal large subunit biogenesis (GO:0042273)3.00692221
78signal transduction involved in cell cycle checkpoint (GO:0072395)3.00507974
79G1/S transition of mitotic cell cycle (GO:0000082)2.99957602
80cell cycle G1/S phase transition (GO:0044843)2.99957602
81negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.99568016
82IMP metabolic process (GO:0046040)2.98378385
83DNA replication-independent nucleosome assembly (GO:0006336)2.98206956
84DNA replication-independent nucleosome organization (GO:0034724)2.98206956
85regulation of protein heterodimerization activity (GO:0043497)2.97576185
86NIK/NF-kappaB signaling (GO:0038061)2.96806504
87chaperone mediated protein folding requiring cofactor (GO:0051085)2.94976953
88nuclear envelope disassembly (GO:0051081)2.94617385
89membrane disassembly (GO:0030397)2.94617385
90negative regulation of cell killing (GO:0031342)2.93853480
91negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.93853480
92negative T cell selection (GO:0043383)2.93633195
93negative regulation of B cell apoptotic process (GO:0002903)2.92363545
94sequestering of actin monomers (GO:0042989)2.92307945
95positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.89774843
96postreplication repair (GO:0006301)2.88179987
97establishment of integrated proviral latency (GO:0075713)2.87595331
98mitotic metaphase plate congression (GO:0007080)2.87307770
99negative thymic T cell selection (GO:0045060)2.87250128
100mitotic chromosome condensation (GO:0007076)2.87192152
101translation (GO:0006412)2.87162801
102telomere organization (GO:0032200)2.86878505
103telomere maintenance (GO:0000723)2.86270511
104regulation of cellular amino acid metabolic process (GO:0006521)2.85833643
105spliceosomal snRNP assembly (GO:0000387)2.84613122
106ribonucleoprotein complex biogenesis (GO:0022613)2.83925145
107leukocyte aggregation (GO:0070486)2.83445796
108regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.82332986
109protein complex disassembly (GO:0043241)2.81608627
110response to interferon-beta (GO:0035456)2.79566383
111positive regulation of ligase activity (GO:0051351)2.78112850
112antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.75952808
113attachment of spindle microtubules to kinetochore (GO:0008608)2.75909628
114transcription-coupled nucleotide-excision repair (GO:0006283)2.75250740
115regulation of defense response to virus by virus (GO:0050690)2.74672406
116COPI coating of Golgi vesicle (GO:0048205)2.73010655
117Golgi transport vesicle coating (GO:0048200)2.73010655
118cullin deneddylation (GO:0010388)2.72627590
119pentose-phosphate shunt (GO:0006098)2.71691906
120negative regulation of T cell apoptotic process (GO:0070233)2.71507296
121positive regulation of cell cycle arrest (GO:0071158)2.71062921
122deoxyribose phosphate catabolic process (GO:0046386)2.70496264
123deoxyribonucleotide catabolic process (GO:0009264)2.69106072
124nucleobase-containing small molecule interconversion (GO:0015949)2.69001839
125protein deneddylation (GO:0000338)2.68027774
126pinocytosis (GO:0006907)2.67888247
127macromolecular complex disassembly (GO:0032984)2.67672872
128establishment of chromosome localization (GO:0051303)2.67646846
129viral mRNA export from host cell nucleus (GO:0046784)2.67245677
130regulation of B cell differentiation (GO:0045577)2.66871355
131mitotic sister chromatid segregation (GO:0000070)2.66442062
132ribosome biogenesis (GO:0042254)2.66274049
133kinetochore organization (GO:0051383)2.66030686
134antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.65583931
135antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.65583931
136neutrophil activation involved in immune response (GO:0002283)2.65392819
137negative regulation of lymphocyte apoptotic process (GO:0070229)2.64544425
138regulation of ubiquitin-protein transferase activity (GO:0051438)2.63630224
139base-excision repair (GO:0006284)2.62870560
140positive regulation of lamellipodium assembly (GO:0010592)2.60421580
141regulation of gamma-delta T cell differentiation (GO:0045586)2.58487693
142positive T cell selection (GO:0043368)2.53837352
143T cell selection (GO:0045058)2.53449834
144pentose metabolic process (GO:0019321)2.49448953
145negative regulation of phagocytosis (GO:0050765)2.49323045
146T cell migration (GO:0072678)2.49130075
147deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.48947683
148regulation of superoxide anion generation (GO:0032928)2.45805638
149regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.45158129
150regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.43816477
151regulation of natural killer cell mediated immunity (GO:0002715)2.43816477
152respiratory burst (GO:0045730)2.43460627
153metallo-sulfur cluster assembly (GO:0031163)2.42732146
154iron-sulfur cluster assembly (GO:0016226)2.42732146
155negative regulation of stress fiber assembly (GO:0051497)2.41011705
156autophagic vacuole fusion (GO:0000046)2.38895106
157NADPH regeneration (GO:0006740)2.38414812
158cellular response to interleukin-15 (GO:0071350)2.38379243
1592-deoxyribonucleotide biosynthetic process (GO:0009265)2.37746436
160deoxyribose phosphate biosynthetic process (GO:0046385)2.37746436
161pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.37185010
162regulation of gamma-delta T cell activation (GO:0046643)2.37145451
163B cell receptor signaling pathway (GO:0050853)2.37070715
164negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.36476215
165positive regulation of lamellipodium organization (GO:1902745)2.36403796
166cellular response to interleukin-4 (GO:0071353)2.36151954
167establishment of viral latency (GO:0019043)2.34595546
168negative regulation of leukocyte apoptotic process (GO:2000107)2.33995113

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.25452380
2* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.17351285
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.63596480
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.36522124
5BP1_19119308_ChIP-ChIP_Hs578T_Human3.20981673
6E2F4_17652178_ChIP-ChIP_JURKAT_Human2.91544349
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.80546223
8GABP_17652178_ChIP-ChIP_JURKAT_Human2.70848813
9EST1_17652178_ChIP-ChIP_JURKAT_Human2.67579097
10FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.67158049
11JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.57682927
12MYC_18358816_ChIP-ChIP_MESCs_Mouse2.54151672
13ETS1_20019798_ChIP-Seq_JURKAT_Human2.51261748
14ELF1_17652178_ChIP-ChIP_JURKAT_Human2.43898771
15MYC_19079543_ChIP-ChIP_MESCs_Mouse2.42325367
16NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.40919519
17CREB1_15753290_ChIP-ChIP_HEK293T_Human2.38925712
18* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.37506924
19XRN2_22483619_ChIP-Seq_HELA_Human2.26205497
20HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.21686065
21MYC_22102868_ChIP-Seq_BL_Human2.17069377
22* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.16230714
23SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.15813342
24VDR_23849224_ChIP-Seq_CD4+_Human2.03876478
25EGR1_19374776_ChIP-ChIP_THP-1_Human2.03719390
26TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.95507573
27E2F1_18555785_ChIP-Seq_MESCs_Mouse1.89716077
28FOXP3_21729870_ChIP-Seq_TREG_Human1.88715284
29DCP1A_22483619_ChIP-Seq_HELA_Human1.87723380
30GABP_19822575_ChIP-Seq_HepG2_Human1.80420323
31* CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.79704010
32* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.72833227
33AR_21909140_ChIP-Seq_LNCAP_Human1.71697705
34* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.69123804
35CIITA_25753668_ChIP-Seq_RAJI_Human1.68330103
36E2F1_21310950_ChIP-Seq_MCF-7_Human1.66420366
37PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.65952116
38THAP11_20581084_ChIP-Seq_MESCs_Mouse1.65309192
39VDR_21846776_ChIP-Seq_THP-1_Human1.62413384
40HOXB4_20404135_ChIP-ChIP_EML_Mouse1.61094029
41TTF2_22483619_ChIP-Seq_HELA_Human1.59486089
42PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.58734488
43ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.55280138
44CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.54682323
45* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.54259550
46* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.53402708
47SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.52972753
48ELK1_19687146_ChIP-ChIP_HELA_Human1.51416457
49MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.51171646
50FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.50032434
51* LXR_22292898_ChIP-Seq_THP-1_Human1.49096888
52HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.46955819
53ERG_20887958_ChIP-Seq_HPC-7_Mouse1.46650793
54MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.44553540
55MYCN_18555785_ChIP-Seq_MESCs_Mouse1.43459790
56IRF8_22096565_ChIP-ChIP_GC-B_Human1.40958014
57IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.40917048
58SRF_21415370_ChIP-Seq_HL-1_Mouse1.40871772
59TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.38469384
60YY1_21170310_ChIP-Seq_MESCs_Mouse1.36329876
61POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.36023722
62NANOG_18555785_ChIP-Seq_MESCs_Mouse1.35355333
63SPI1_23547873_ChIP-Seq_NB4_Human1.35117607
64SRY_22984422_ChIP-ChIP_TESTIS_Rat1.30866112
65* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.30368966
66ELF1_20517297_ChIP-Seq_JURKAT_Human1.29232187
67MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.28979672
68TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.28947560
69* BCL6_27268052_Chip-Seq_Bcells_Human1.28944530
70TFEB_21752829_ChIP-Seq_HELA_Human1.28883079
71E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.28837331
72IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.28256194
73KDM5A_27292631_Chip-Seq_BREAST_Human1.27964860
74PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.25906184
75* TET1_21451524_ChIP-Seq_MESCs_Mouse1.24996535
76BRD4_27068464_Chip-Seq_AML-cells_Mouse1.24313060
77CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.23427208
78ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.22762736
79ZNF263_19887448_ChIP-Seq_K562_Human1.21937664
80YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.20756457
81P68_20966046_ChIP-Seq_HELA_Human1.19484888
82RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.18792450
83* BCOR_27268052_Chip-Seq_Bcells_Human1.18185076
84CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.17027267
85RACK7_27058665_Chip-Seq_MCF-7_Human1.16841941
86KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.16390454
87GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.15195689
88PU.1_20513432_ChIP-Seq_Bcells_Mouse1.15189342
89MAF_26560356_Chip-Seq_TH1_Human1.14390047
90* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.13209984
91UTX_26944678_Chip-Seq_JUKART_Human1.12087023
92STAT4_19710469_ChIP-ChIP_TH1__Mouse1.10385456
93IRF8_21731497_ChIP-ChIP_J774_Mouse1.10027327
94* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.09969784
95CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.09285811
96PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.08492428
97HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.08352516
98DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.07428012
99* CTCF_26484167_Chip-Seq_Bcells_Mouse1.07266103
100CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.07009786
101E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.06688189
102RARG_19884340_ChIP-ChIP_MEFs_Mouse1.06293545
103CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.06127835
104* MYB_26560356_Chip-Seq_TH2_Human1.06077895
105NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.05744456
106NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.05408842
107* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.05126206
108GATA2_22383799_ChIP-Seq_G1ME_Mouse1.05018464
109BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.04580564
110MYB_21317192_ChIP-Seq_ERMYB_Mouse1.03479940
111CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.02872078
112STAT3_1855785_ChIP-Seq_MESCs_Mouse1.00690921
113POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.99283772
114CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.97086748
115* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.95769311
116RUNX1_22412390_ChIP-Seq_EML_Mouse0.94049345
117KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.93662137
118MYB_26560356_Chip-Seq_TH1_Human0.92597031
119ELK3_25401928_ChIP-Seq_HUVEC_Human0.92499628
120* GATA1_22383799_ChIP-Seq_G1ME_Mouse0.92405492
121CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.90671995
122ELK1_22589737_ChIP-Seq_MCF10A_Human0.89401167
123VDR_24763502_ChIP-Seq_THP-1_Human0.89231737
124* MAF_26560356_Chip-Seq_TH2_Human0.88773482
125CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.86296108
126PADI4_21655091_ChIP-ChIP_MCF-7_Human0.85074803
127KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.84272614

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.42252921
2MP0004957_abnormal_blastocyst_morpholog3.67619807
3MP0010094_abnormal_chromosome_stability3.53980948
4MP0003077_abnormal_cell_cycle3.28009760
5MP0003111_abnormal_nucleus_morphology3.25298748
6MP0002396_abnormal_hematopoietic_system2.84105064
7MP0008007_abnormal_cellular_replicative2.61871197
8MP0003763_abnormal_thymus_physiology2.49094931
9MP0008058_abnormal_DNA_repair2.36065076
10MP0001835_abnormal_antigen_presentation2.29299388
11MP0005058_abnormal_lysosome_morphology2.25556973
12MP0008057_abnormal_DNA_replication2.21355323
13MP0010352_gastrointestinal_tract_polyps2.20807294
14MP0005451_abnormal_body_composition2.20533587
15MP0006054_spinal_hemorrhage2.20348649
16MP0009333_abnormal_splenocyte_physiolog2.08055148
17MP0003191_abnormal_cellular_cholesterol2.02592576
18MP0000685_abnormal_immune_system2.01744957
19MP0008932_abnormal_embryonic_tissue1.95447989
20MP0001730_embryonic_growth_arrest1.92912884
21MP0005671_abnormal_response_to1.91940592
22MP0002398_abnormal_bone_marrow1.89338022
23MP0004808_abnormal_hematopoietic_stem1.85378588
24MP0000490_abnormal_crypts_of1.85108423
25MP0006082_CNS_inflammation1.83560957
26MP0008260_abnormal_autophagy1.83389933
27MP0010307_abnormal_tumor_latency1.72780424
28MP0000350_abnormal_cell_proliferation1.70912650
29MP0002722_abnormal_immune_system1.68769834
30MP0003123_paternal_imprinting1.66737801
31MP0001800_abnormal_humoral_immune1.65814521
32MP0000689_abnormal_spleen_morphology1.63941669
33MP0009785_altered_susceptibility_to1.62652390
34MP0002019_abnormal_tumor_incidence1.62562938
35MP0002877_abnormal_melanocyte_morpholog1.59541091
36MP0000703_abnormal_thymus_morphology1.58465972
37MP0002420_abnormal_adaptive_immunity1.57447548
38MP0001819_abnormal_immune_cell1.55198275
39MP0002452_abnormal_antigen_presenting1.53861251
40MP0009840_abnormal_foam_cell1.52502023
41MP0003786_premature_aging1.51166307
42MP0000858_altered_metastatic_potential1.50628280
43MP0002429_abnormal_blood_cell1.50416388
44MP0000716_abnormal_immune_system1.48189155
45MP0000313_abnormal_cell_death1.42079976
46MP0003436_decreased_susceptibility_to1.40397703
47MP0002166_altered_tumor_susceptibility1.40013256
48MP0002723_abnormal_immune_serum1.38957769
49MP0005000_abnormal_immune_tolerance1.38708812
50MP0002405_respiratory_system_inflammati1.38054959
51MP0008469_abnormal_protein_level1.36613340
52MP0005397_hematopoietic_system_phenotyp1.36482723
53MP0001545_abnormal_hematopoietic_system1.36482723
54MP0003806_abnormal_nucleotide_metabolis1.35855063
55MP0005025_abnormal_response_to1.33863476
56MP0003186_abnormal_redox_activity1.33134142
57MP0002080_prenatal_lethality1.32140115
58MP0001697_abnormal_embryo_size1.31236098
59MP0001853_heart_inflammation1.29324211
60MP0005023_abnormal_wound_healing1.26844302
61MP0005075_abnormal_melanosome_morpholog1.20502141
62MP0002006_tumorigenesis1.18386283
63MP0010155_abnormal_intestine_physiology1.16181787
64MP0008438_abnormal_cutaneous_collagen1.14856991
65MP0003566_abnormal_cell_adhesion1.14702563
66MP0001672_abnormal_embryogenesis/_devel1.12662424
67MP0005380_embryogenesis_phenotype1.12662424
68MP0003984_embryonic_growth_retardation1.12049796
69MP0005387_immune_system_phenotype1.10896815
70MP0001790_abnormal_immune_system1.10896815
71MP0002148_abnormal_hypersensitivity_rea1.10738367
72MP0002088_abnormal_embryonic_growth/wei1.08788975
73MP0002132_abnormal_respiratory_system1.08601518
74MP0005464_abnormal_platelet_physiology1.05077088
75MP0003705_abnormal_hypodermis_morpholog1.04800084
76MP0002419_abnormal_innate_immunity1.03345847
77MP0004381_abnormal_hair_follicle1.01704044
78MP0003075_altered_response_to1.01302666
79MP0000358_abnormal_cell_content/1.00596397
80MP0002086_abnormal_extraembryonic_tissu1.00010289
81MP0003221_abnormal_cardiomyocyte_apopto0.99802738
82MP0004185_abnormal_adipocyte_glucose0.98999046
83MP0005310_abnormal_salivary_gland0.98389081
84MP0005501_abnormal_skin_physiology0.98265016
85MP0009764_decreased_sensitivity_to0.97751855
86MP0002933_joint_inflammation0.97610993
87MP0003567_abnormal_fetal_cardiomyocyte0.97600440
88MP0005083_abnormal_biliary_tract0.94905474
89MP0004197_abnormal_fetal_growth/weight/0.93921963
90MP0009763_increased_sensitivity_to0.93820195
91MP0001845_abnormal_inflammatory_respons0.93691833
92MP0003866_abnormal_defecation0.92270480
93MP0001873_stomach_inflammation0.91981987
94MP0000465_gastrointestinal_hemorrhage0.91779021
95MP0001727_abnormal_embryo_implantation0.91171196
96MP0002085_abnormal_embryonic_tissue0.90269087
97MP0003172_abnormal_lysosome_physiology0.89008360
98MP0002796_impaired_skin_barrier0.88217748
99MP0005076_abnormal_cell_differentiation0.88061522
100MP0000343_altered_response_to0.86092468
101MP0006036_abnormal_mitochondrial_physio0.85883967
102MP0006035_abnormal_mitochondrial_morpho0.84304686
103MP0004947_skin_inflammation0.82946488
104MP0004264_abnormal_extraembryonic_tissu0.81478387
105MP0003448_altered_tumor_morphology0.81473100
106MP0001881_abnormal_mammary_gland0.79964265
107MP0000477_abnormal_intestine_morphology0.78664227
108MP0010030_abnormal_orbit_morphology0.78178977
109MP0003279_aneurysm0.78165295
110MP0005166_decreased_susceptibility_to0.78007926
111MP0005319_abnormal_enzyme/_coenzyme0.77982750
112MP0003724_increased_susceptibility_to0.76376888
113MP0002084_abnormal_developmental_patter0.74758025
114MP0005165_increased_susceptibility_to0.74419023
115MP0005384_cellular_phenotype0.74381437
116MP0009278_abnormal_bone_marrow0.73033018
117MP0008877_abnormal_DNA_methylation0.72672975
118MP0005621_abnormal_cell_physiology0.70853981
119MP0001533_abnormal_skeleton_physiology0.70738211
120MP0005584_abnormal_enzyme/coenzyme_acti0.70125224
121MP0003300_gastrointestinal_ulcer0.68997397
122MP0003303_peritoneal_inflammation0.68693300
123MP0001243_abnormal_dermal_layer0.65800697
124MP0001851_eye_inflammation0.64863697
125MP0001663_abnormal_digestive_system0.64388613
126MP0008873_increased_physiological_sensi0.64338419
127MP0001915_intracranial_hemorrhage0.64173729
128MP0003943_abnormal_hepatobiliary_system0.64038309
129MP0000609_abnormal_liver_physiology0.63962132
130MP0004084_abnormal_cardiac_muscle0.63836211
131MP0009643_abnormal_urine_homeostasis0.63347256
132MP0001849_ear_inflammation0.63052854
133MP0003121_genomic_imprinting0.62866334

Predicted human phenotypes

RankGene SetZ-score
1Reticulocytopenia (HP:0001896)3.82105172
2Abnormality of macrophages (HP:0004311)3.67483054
3Abnormal number of erythroid precursors (HP:0012131)3.60839235
4Increased IgM level (HP:0003496)3.59927226
5Abnormality of cells of the erythroid lineage (HP:0012130)3.59550522
6IgM deficiency (HP:0002850)3.47883566
7Thrombocytosis (HP:0001894)3.33500395
8Chronic obstructive pulmonary disease (HP:0006510)3.33235584
9Obstructive lung disease (HP:0006536)3.33235584
10Autoimmune hemolytic anemia (HP:0001890)3.24773913
11Recurrent bacterial skin infections (HP:0005406)3.09733874
12Meningitis (HP:0001287)3.09389771
13Abnormality of the anterior horn cell (HP:0006802)3.07843668
14Degeneration of anterior horn cells (HP:0002398)3.07843668
15Birth length less than 3rd percentile (HP:0003561)3.06512156
16Multiple enchondromatosis (HP:0005701)3.05404282
17Elevated erythrocyte sedimentation rate (HP:0003565)3.02207854
18Aplastic anemia (HP:0001915)3.00683383
19Selective tooth agenesis (HP:0001592)2.93446477
20Oral leukoplakia (HP:0002745)2.88040102
21Mediastinal lymphadenopathy (HP:0100721)2.83187778
22Hepatosplenomegaly (HP:0001433)2.78233016
23Recurrent bronchitis (HP:0002837)2.76088553
24Colon cancer (HP:0003003)2.74026834
25Abnormal delayed hypersensitivity skin test (HP:0002963)2.69379411
2611 pairs of ribs (HP:0000878)2.69212162
27Abnormality of glycolipid metabolism (HP:0010969)2.65309759
28Abnormality of liposaccharide metabolism (HP:0010968)2.65309759
29Abnormality of glycosphingolipid metabolism (HP:0004343)2.65309759
30Ragged-red muscle fibers (HP:0003200)2.63190744
31Combined immunodeficiency (HP:0005387)2.55592388
32Trismus (HP:0000211)2.52018030
33Myositis (HP:0100614)2.51415025
34Autoimmune thrombocytopenia (HP:0001973)2.50458874
35Severe combined immunodeficiency (HP:0004430)2.49106075
36Abnormality of T cells (HP:0002843)2.48774525
37Encephalitis (HP:0002383)2.48641693
38Microretrognathia (HP:0000308)2.48479976
39Increased intramyocellular lipid droplets (HP:0012240)2.46709766
40Pustule (HP:0200039)2.45293073
41Increased serum ferritin (HP:0003281)2.43180898
42Hypertensive crisis (HP:0100735)2.41693359
43Urticaria (HP:0001025)2.40422436
44Increased IgE level (HP:0003212)2.39495119
45IgG deficiency (HP:0004315)2.38377199
46Petechiae (HP:0000967)2.38011274
47Hypergammaglobulinemia (HP:0010702)2.37994669
48Microvesicular hepatic steatosis (HP:0001414)2.36316680
49Lymphoma (HP:0002665)2.31496382
50Stomatitis (HP:0010280)2.31146666
51Purpura (HP:0000979)2.30566473
52Poor head control (HP:0002421)2.30271209
53Cellulitis (HP:0100658)2.29708505
54Agnosia (HP:0010524)2.29609855
55Increased cerebral lipofuscin (HP:0011813)2.29457533
56Increased muscle lipid content (HP:0009058)2.29101098
57Abnormality of T cell physiology (HP:0011840)2.28015337
58Increased neuronal autofluorescent lipopigment (HP:0002074)2.26757177
59Recurrent cutaneous fungal infections (HP:0011370)2.24596999
60Chronic mucocutaneous candidiasis (HP:0002728)2.24596999
61T lymphocytopenia (HP:0005403)2.23856251
62Abnormality of B cell number (HP:0010975)2.22300848
63B lymphocytopenia (HP:0010976)2.22300848
64Abnormality of the calcaneus (HP:0008364)2.21566007
65Pallor (HP:0000980)2.21146595
66Recurrent skin infections (HP:0001581)2.20048512
67Gastrointestinal inflammation (HP:0004386)2.19895284
68Macrocytic anemia (HP:0001972)2.19807790
69Basal cell carcinoma (HP:0002671)2.19466347
70Abnormality of the prostate (HP:0008775)2.19400287
71Progressive neurologic deterioration (HP:0002344)2.17757018
72Carpal bone hypoplasia (HP:0001498)2.16942922
73Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.16415182
74Decreased activity of mitochondrial respiratory chain (HP:0008972)2.16415182
75Vasculitis (HP:0002633)2.15453542
76Cerebral palsy (HP:0100021)2.15067723
77Slender long bone (HP:0003100)2.14742923
78Aplasia/Hypoplasia of the sacrum (HP:0008517)2.14206295
79Cholecystitis (HP:0001082)2.14168287
80Abnormal gallbladder physiology (HP:0012438)2.14168287
81Abnormality of T cell number (HP:0011839)2.13859995
82Abnormality of cells of the lymphoid lineage (HP:0012140)2.13554453
83Vacuolated lymphocytes (HP:0001922)2.13547227
84Recurrent viral infections (HP:0004429)2.12559870
85Eosinophilia (HP:0001880)2.12003575
86Neoplasm of the pancreas (HP:0002894)2.11624844
87Rough bone trabeculation (HP:0100670)2.10475290
88Patellar aplasia (HP:0006443)2.09219542
89Lymphopenia (HP:0001888)2.08638183
90Skin rash (HP:0000988)2.08204135
91Chronic otitis media (HP:0000389)2.07484808
92Recurrent abscess formation (HP:0002722)2.07314732
93Premature graying of hair (HP:0002216)2.06611979
94Abnormal mitochondria in muscle tissue (HP:0008316)2.06388027
95Papilloma (HP:0012740)2.05611725
96Verrucae (HP:0200043)2.05611725
97Missing ribs (HP:0000921)2.04099562
98Acute hepatic failure (HP:0006554)2.03513335
99Breast hypoplasia (HP:0003187)2.02871849
100Eczematoid dermatitis (HP:0000976)2.01528842
101Atrophy/Degeneration involving motor neurons (HP:0007373)2.01091461
102Nonimmune hydrops fetalis (HP:0001790)2.00969786
103Inflammation of the large intestine (HP:0002037)2.00540783
104Protrusio acetabuli (HP:0003179)2.00202823
105Cutaneous melanoma (HP:0012056)2.00101999
106Chest pain (HP:0100749)1.98812405
107Cellular immunodeficiency (HP:0005374)1.96505156
108Cerebral hypomyelination (HP:0006808)1.95667415
109Adenoma sebaceum (HP:0009720)1.93917286
110Angiofibromas (HP:0010615)1.93917286
111Aplasia/Hypoplasia of the patella (HP:0006498)1.91655059
112Leukocytosis (HP:0001974)1.91539438
113Mitochondrial inheritance (HP:0001427)1.89334441
114Ependymoma (HP:0002888)1.89072086
115Poikiloderma (HP:0001029)1.88896041
116Chronic diarrhea (HP:0002028)1.88020541
117Epistaxis (HP:0000421)1.87990475
118Centrally nucleated skeletal muscle fibers (HP:0003687)1.87613007
119Type I transferrin isoform profile (HP:0003642)1.87474117
120Abnormal trabecular bone morphology (HP:0100671)1.86890991
121Aplasia/Hypoplasia of the thymus (HP:0010515)1.86641004
122Colitis (HP:0002583)1.85863686
123Panhypogammaglobulinemia (HP:0003139)1.84980719
124Abnormality of eosinophils (HP:0001879)1.83867582
125Agammaglobulinemia (HP:0004432)1.83781840
126Hepatic necrosis (HP:0002605)1.83501244
127Hypoplasia of the capital femoral epiphysis (HP:0003090)1.82773975
128Progressive muscle weakness (HP:0003323)1.82465752
129Myelodysplasia (HP:0002863)1.82455534
130High pitched voice (HP:0001620)1.81844715
131Seborrheic dermatitis (HP:0001051)1.81451665
132Abnormality of iron homeostasis (HP:0011031)1.81450688
133Sepsis (HP:0100806)1.81376872
134Hepatocellular necrosis (HP:0001404)1.81362226
135Prolonged neonatal jaundice (HP:0006579)1.80951308
136Skin ulcer (HP:0200042)1.80803580
137Medulloblastoma (HP:0002885)1.80224503
138Pulmonary infiltrates (HP:0002113)1.80097238
139Increased density of long bones (HP:0006392)1.80096518
140Recurrent fungal infections (HP:0002841)1.78144042
141Increased serum lactate (HP:0002151)1.77308984
142IgA deficiency (HP:0002720)1.77114360
143Muscle fiber atrophy (HP:0100295)1.75533347
144Amaurosis fugax (HP:0100576)1.74988607
145Absent thumb (HP:0009777)1.73679288
146Abnormality of chromosome stability (HP:0003220)1.73174606
147Vertebral compression fractures (HP:0002953)1.71843025
148Cervical subluxation (HP:0003308)1.71603147
149Bone marrow hypocellularity (HP:0005528)1.71331356
150Granulocytopenia (HP:0001913)1.70849564
151Glossoptosis (HP:0000162)1.70133335
152Optic nerve coloboma (HP:0000588)1.68225633
153Ankle contracture (HP:0006466)1.65707432
154Neoplasm of the adrenal gland (HP:0100631)1.64784243
155Deviation of the thumb (HP:0009603)1.63637007
156Abnormal number of incisors (HP:0011064)1.62956217
157Pancytopenia (HP:0001876)1.62518887
158Meckel diverticulum (HP:0002245)1.62428241
159Abnormal protein glycosylation (HP:0012346)1.60034840
160Abnormal glycosylation (HP:0012345)1.60034840
161Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.60034840
162Abnormal protein N-linked glycosylation (HP:0012347)1.60034840

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB13.97072379
2VRK23.42895545
3TESK23.27257522
4EIF2AK12.97433754
5CDC72.92070438
6WEE12.72504959
7MAP4K12.64853413
8KDR2.46430511
9NME22.46222750
10SMG12.38230356
11TESK12.27512791
12NEK12.20790376
13PKN22.05413753
14SCYL22.04848845
15NEK22.01655311
16TRIB31.86165320
17IRAK31.85082067
18PASK1.83983996
19ACVR1B1.83114662
20EEF2K1.73474433
21RPS6KA41.71592777
22TLK11.68513482
23LRRK21.63749486
24TGFBR11.60826027
25EIF2AK31.59756490
26ZAP701.58433817
27MAP3K101.55008573
28BLK1.54100170
29STK101.53397286
30PAK41.49908472
31ARAF1.49508518
32BRSK21.48899173
33STK161.45989488
34RIPK41.45647027
35FES1.44058670
36TSSK61.41405909
37SRPK11.41369162
38PIM21.40223664
39FLT31.39414995
40LIMK11.38513678
41RPS6KB21.35493240
42TAOK21.31275347
43VRK11.31185843
44BRSK11.26555052
45AURKB1.24523302
46BTK1.21497125
47ERN11.20271718
48CCNB11.16303769
49PLK11.16274519
50MAP3K81.15239558
51JAK31.13788772
52ATR1.10570903
53MAP2K31.10326809
54ILK1.09199395
55PRPF4B1.07069097
56CDK71.05869092
57CSK1.04980689
58MAPKAPK31.04820855
59CDK41.01990671
60BCKDK1.00653655
61TXK0.96319662
62MAP3K120.96122064
63MAP3K140.96053064
64MAP3K110.94037629
65STK40.92405919
66AURKA0.92226587
67DYRK30.90964163
68TTK0.89147900
69PLK40.85868250
70KIT0.85175092
71TYK20.85104630
72CSF1R0.84765369
73IKBKB0.83321394
74TBK10.80504422
75PIM10.78741012
76GRK60.78018433
77TAOK30.77544539
78TTN0.76570690
79CLK10.73741854
80MYLK0.71613800
81SYK0.71252287
82TEC0.70380416
83PAK10.68014293
84SIK10.67486418
85TAOK10.67132103
86NEK90.65413683
87CDK80.64208212
88TNK20.62324711
89PLK30.61565539
90IKBKE0.60041228
91MAP3K130.59617402
92ABL20.58927993
93CHEK10.57523110
94EPHA20.57502116
95DAPK10.56918426
96ITK0.54883913
97MAP2K20.54796265
98LYN0.54727621
99HCK0.53795297
100MAP3K30.52383223
101MUSK0.48818411
102BRAF0.48818000
103MKNK10.48448689
104MAP3K10.48433641
105PRKCQ0.47186402
106LCK0.46348053
107CSNK2A10.44880788
108IRAK40.43742061
109CHEK20.43440074
110MAPKAPK20.42655104
111MAPK110.41788878
112PTK60.41770000
113MST1R0.39824095
114NME10.37884913
115MATK0.37854826
116ZAK0.37596577
117CSNK2A20.36615952
118DAPK30.34786531
119RPS6KA60.34436181
120PRKCI0.34422631
121PBK0.34279567
122MST40.32181423
123* CDK20.31977165
124MARK30.31965799
125FGFR40.31710922
126RPS6KL10.30856497
127RPS6KC10.30856497
128PRKD20.30834047
129SIK30.29317210
130RAF10.28496051
131PDPK10.27532813

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.96160886
2Mismatch repair_Homo sapiens_hsa034303.94206445
3Proteasome_Homo sapiens_hsa030503.93502231
4Ribosome_Homo sapiens_hsa030103.43884768
5Base excision repair_Homo sapiens_hsa034103.07998557
6Spliceosome_Homo sapiens_hsa030402.82208994
7Nucleotide excision repair_Homo sapiens_hsa034202.62535820
8Homologous recombination_Homo sapiens_hsa034402.56830589
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.37493935
10Autoimmune thyroid disease_Homo sapiens_hsa053202.33756359
11Cell cycle_Homo sapiens_hsa041102.31240426
12RNA transport_Homo sapiens_hsa030132.30857292
13RNA polymerase_Homo sapiens_hsa030202.25995054
14Pyrimidine metabolism_Homo sapiens_hsa002402.17349150
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.15687660
16One carbon pool by folate_Homo sapiens_hsa006702.03660708
17Non-homologous end-joining_Homo sapiens_hsa034501.95147123
18Primary immunodeficiency_Homo sapiens_hsa053401.89469583
19Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.58599380
20Antigen processing and presentation_Homo sapiens_hsa046121.48847134
21Asthma_Homo sapiens_hsa053101.46625287
22Type I diabetes mellitus_Homo sapiens_hsa049401.45143491
23p53 signaling pathway_Homo sapiens_hsa041151.43378343
24Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.42230465
25RNA degradation_Homo sapiens_hsa030181.41422842
26Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.28573797
27Protein export_Homo sapiens_hsa030601.25337460
28Fanconi anemia pathway_Homo sapiens_hsa034601.21086101
29Legionellosis_Homo sapiens_hsa051341.20910008
30Pentose phosphate pathway_Homo sapiens_hsa000301.19065082
31Epstein-Barr virus infection_Homo sapiens_hsa051691.19004036
32Shigellosis_Homo sapiens_hsa051311.11547560
33Fatty acid elongation_Homo sapiens_hsa000621.04850949
34Systemic lupus erythematosus_Homo sapiens_hsa053221.03213220
35Rheumatoid arthritis_Homo sapiens_hsa053231.02111611
36Viral carcinogenesis_Homo sapiens_hsa052031.02034078
37Purine metabolism_Homo sapiens_hsa002301.01782825
38Basal transcription factors_Homo sapiens_hsa030221.00221209
39* Herpes simplex infection_Homo sapiens_hsa051680.97659720
40Toll-like receptor signaling pathway_Homo sapiens_hsa046200.96037123
41* mRNA surveillance pathway_Homo sapiens_hsa030150.92918697
42Biosynthesis of amino acids_Homo sapiens_hsa012300.91605394
43Viral myocarditis_Homo sapiens_hsa054160.91595458
44Staphylococcus aureus infection_Homo sapiens_hsa051500.91209434
45HTLV-I infection_Homo sapiens_hsa051660.90777700
46Sulfur metabolism_Homo sapiens_hsa009200.90549574
47Measles_Homo sapiens_hsa051620.90395534
48Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.89950617
49Glycosaminoglycan degradation_Homo sapiens_hsa005310.89362408
50Parkinsons disease_Homo sapiens_hsa050120.88330035
51Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.87466302
52Lysosome_Homo sapiens_hsa041420.86977836
53Leishmaniasis_Homo sapiens_hsa051400.85370776
54Carbon metabolism_Homo sapiens_hsa012000.85028278
552-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.84134463
56N-Glycan biosynthesis_Homo sapiens_hsa005100.83042255
57Apoptosis_Homo sapiens_hsa042100.81941185
58Thyroid cancer_Homo sapiens_hsa052160.75516828
59Intestinal immune network for IgA production_Homo sapiens_hsa046720.74645697
60NF-kappa B signaling pathway_Homo sapiens_hsa040640.71876700
61SNARE interactions in vesicular transport_Homo sapiens_hsa041300.68391958
62Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.66894441
63Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.66656690
64Leukocyte transendothelial migration_Homo sapiens_hsa046700.65906268
65Drug metabolism - other enzymes_Homo sapiens_hsa009830.64647298
66Malaria_Homo sapiens_hsa051440.63869741
67Small cell lung cancer_Homo sapiens_hsa052220.63680381
68Hematopoietic cell lineage_Homo sapiens_hsa046400.63010983
69B cell receptor signaling pathway_Homo sapiens_hsa046620.60523204
70Hepatitis B_Homo sapiens_hsa051610.59957591
71Alzheimers disease_Homo sapiens_hsa050100.58438048
72Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.57985675
73Selenocompound metabolism_Homo sapiens_hsa004500.56412400
74Huntingtons disease_Homo sapiens_hsa050160.56318121
75Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.55715741
76Folate biosynthesis_Homo sapiens_hsa007900.55622826
77Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.55278650
78Phagosome_Homo sapiens_hsa041450.53685816
79Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.53148938
80Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.53015188
81Chronic myeloid leukemia_Homo sapiens_hsa052200.52813542
82Vibrio cholerae infection_Homo sapiens_hsa051100.52314214
83Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.51618261
84Galactose metabolism_Homo sapiens_hsa000520.51146820
85Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.49938782
86Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.49303846
87NOD-like receptor signaling pathway_Homo sapiens_hsa046210.47696667
88Sulfur relay system_Homo sapiens_hsa041220.47567803
89Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.46536258
90Endocytosis_Homo sapiens_hsa041440.46525896
91Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.45865487
92T cell receptor signaling pathway_Homo sapiens_hsa046600.45477264
93Other glycan degradation_Homo sapiens_hsa005110.45273283
94Influenza A_Homo sapiens_hsa051640.44789030
95Cysteine and methionine metabolism_Homo sapiens_hsa002700.44780400
96* Oocyte meiosis_Homo sapiens_hsa041140.44161691
97Hepatitis C_Homo sapiens_hsa051600.42910007
98RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.42884787
99Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.42754135
100Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.42599446
101Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.41958940
102Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.41638358
103Oxidative phosphorylation_Homo sapiens_hsa001900.41074805
104Colorectal cancer_Homo sapiens_hsa052100.40490799
105Allograft rejection_Homo sapiens_hsa053300.40225774
106Cyanoamino acid metabolism_Homo sapiens_hsa004600.39360301
107Pertussis_Homo sapiens_hsa051330.39233267
108Salmonella infection_Homo sapiens_hsa051320.38912190
109Toxoplasmosis_Homo sapiens_hsa051450.38241909
110Bladder cancer_Homo sapiens_hsa052190.38005909
111HIF-1 signaling pathway_Homo sapiens_hsa040660.37867968
112Acute myeloid leukemia_Homo sapiens_hsa052210.36989826
113Pancreatic cancer_Homo sapiens_hsa052120.35579106
114Fructose and mannose metabolism_Homo sapiens_hsa000510.34035262
115Glutathione metabolism_Homo sapiens_hsa004800.33597855
116Graft-versus-host disease_Homo sapiens_hsa053320.32520023
117Transcriptional misregulation in cancer_Homo sapiens_hsa052020.30173654
118MicroRNAs in cancer_Homo sapiens_hsa052060.28350587
119Jak-STAT signaling pathway_Homo sapiens_hsa046300.28343140
120Osteoclast differentiation_Homo sapiens_hsa043800.27059553
121* Alcoholism_Homo sapiens_hsa050340.27026571
122Central carbon metabolism in cancer_Homo sapiens_hsa052300.26226397
123Non-small cell lung cancer_Homo sapiens_hsa052230.25602488
124Tuberculosis_Homo sapiens_hsa051520.24875989

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »