PPP1CB

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is one of the three catalytic subunits of protein phosphatase 1 (PP1). PP1 is a serine/threonine specific protein phosphatase known to be involved in the regulation of a variety of cellular processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viral transcription. Mouse studies suggest that PP1 functions as a suppressor of learning and memory. Two alternatively spliced transcript variants encoding distinct isoforms have been observed. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of protein autophosphorylation (GO:0031954)4.72483848
2keratinocyte development (GO:0003334)4.54388723
3regulation of hexokinase activity (GO:1903299)4.54304287
4regulation of glucokinase activity (GO:0033131)4.54304287
5lactate metabolic process (GO:0006089)4.45842842
6DNA double-strand break processing (GO:0000729)4.13830978
7positive regulation of glycoprotein biosynthetic process (GO:0010560)3.84629630
8respiratory chain complex IV assembly (GO:0008535)3.82275594
9response to pheromone (GO:0019236)3.69266174
10platelet dense granule organization (GO:0060155)3.65174358
11proteasome assembly (GO:0043248)3.41339188
12negative regulation of DNA-dependent DNA replication (GO:2000104)3.41163821
13inositol phosphate catabolic process (GO:0071545)3.40600118
14prenylation (GO:0097354)3.33747290
15protein prenylation (GO:0018342)3.33747290
16synapsis (GO:0007129)3.33148275
17water-soluble vitamin biosynthetic process (GO:0042364)3.32524005
18replication fork processing (GO:0031297)3.30521732
19signal peptide processing (GO:0006465)3.28001470
20positive regulation of glycoprotein metabolic process (GO:1903020)3.25602791
21cytochrome complex assembly (GO:0017004)3.24888919
22regulation of protein autophosphorylation (GO:0031952)3.24354328
23membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.21748433
24cullin deneddylation (GO:0010388)3.16412288
25locomotory exploration behavior (GO:0035641)3.06348871
26protein K6-linked ubiquitination (GO:0085020)3.05508745
27ketone body metabolic process (GO:1902224)3.04651518
28relaxation of smooth muscle (GO:0044557)3.03534716
29atrial cardiac muscle cell action potential (GO:0086014)3.02358839
30positive regulation of glycolytic process (GO:0045821)3.02286843
31negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.00708329
32branched-chain amino acid catabolic process (GO:0009083)2.96526251
33polyol catabolic process (GO:0046174)2.95515241
34histone H2A acetylation (GO:0043968)2.94249079
35regulation of sulfur metabolic process (GO:0042762)2.93932159
36dorsal/ventral axis specification (GO:0009950)2.93615562
37negative regulation of neurological system process (GO:0031645)2.92931183
38cornea development in camera-type eye (GO:0061303)2.90203784
39regulation of synaptic vesicle exocytosis (GO:2000300)2.89944722
40phosphorylated carbohydrate dephosphorylation (GO:0046838)2.88095354
41inositol phosphate dephosphorylation (GO:0046855)2.88095354
42regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.87981128
43vesicle transport along microtubule (GO:0047496)2.84276202
44zinc ion transport (GO:0006829)2.83262011
45kidney morphogenesis (GO:0060993)2.83136748
46cytoplasmic mRNA processing body assembly (GO:0033962)2.82204579
47regulation of protein glycosylation (GO:0060049)2.82072120
48synaptic vesicle maturation (GO:0016188)2.82059010
49regulation of meiosis I (GO:0060631)2.82000494
50COPI coating of Golgi vesicle (GO:0048205)2.80532103
51Golgi transport vesicle coating (GO:0048200)2.80532103
52detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.80387940
53somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.79951679
54somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.79951679
55isotype switching (GO:0045190)2.79951679
56membrane repolarization during action potential (GO:0086011)2.78527846
57parental behavior (GO:0060746)2.78442686
58glial cell proliferation (GO:0014009)2.78414878
59protein localization to endosome (GO:0036010)2.78386110
60positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.75753286
61positive regulation of response to oxidative stress (GO:1902884)2.74956032
62positive regulation of cellular response to oxidative stress (GO:1900409)2.74956032
63protein deneddylation (GO:0000338)2.73893511
64cardiac myofibril assembly (GO:0055003)2.71233193
65negative regulation of JUN kinase activity (GO:0043508)2.70891424
66negative regulation of potassium ion transmembrane transport (GO:1901380)2.70556817
67histone exchange (GO:0043486)2.70089604
68RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.69902014
69detection of calcium ion (GO:0005513)2.68634306
70peptidyl-cysteine modification (GO:0018198)2.68498389
71layer formation in cerebral cortex (GO:0021819)2.67389182
72regulation of nuclear cell cycle DNA replication (GO:0033262)2.67227906
73muscle cell cellular homeostasis (GO:0046716)2.65093161
74relaxation of muscle (GO:0090075)2.64304970
75protein heterotrimerization (GO:0070208)2.64137273
76female gonad development (GO:0008585)2.63744841
77nerve growth factor signaling pathway (GO:0038180)2.63405436
78regulation of Rac protein signal transduction (GO:0035020)2.63076937
79sequestering of metal ion (GO:0051238)2.62580820
80cardiac conduction (GO:0061337)2.62410379
81transcytosis (GO:0045056)2.61141242
82dendritic spine morphogenesis (GO:0060997)2.60919775
83cellular ketone body metabolic process (GO:0046950)2.60316515
84intraciliary transport (GO:0042073)2.59195830
85regulation of heart rate by cardiac conduction (GO:0086091)2.58881255
86L-fucose catabolic process (GO:0042355)2.57815394
87fucose catabolic process (GO:0019317)2.57815394
88L-fucose metabolic process (GO:0042354)2.57815394
89glucocorticoid receptor signaling pathway (GO:0042921)2.57328361
90positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.57169277
91myotube differentiation (GO:0014902)2.56968592
92protein K11-linked deubiquitination (GO:0035871)2.56220081
93regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.55612552
94activation of protein kinase A activity (GO:0034199)2.55436671
95multicellular organismal signaling (GO:0035637)2.55093157
96limb bud formation (GO:0060174)2.55029198
97DNA deamination (GO:0045006)2.54262261
98axonal fasciculation (GO:0007413)2.52594324
99positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.49372604
100positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.49372604
101positive regulation of mitotic sister chromatid separation (GO:1901970)2.49372604
102transmission of nerve impulse (GO:0019226)2.48991236
103pancreas development (GO:0031016)2.47459718
104regulation of type B pancreatic cell apoptotic process (GO:2000674)2.46739433
105regulation of dendritic spine morphogenesis (GO:0061001)2.46601996
106positive regulation of actin filament depolymerization (GO:0030836)2.46129635
107regulation of cAMP-dependent protein kinase activity (GO:2000479)2.45837341
108Rap protein signal transduction (GO:0032486)2.45467513
109establishment of nucleus localization (GO:0040023)2.45243035
110insulin-like growth factor receptor signaling pathway (GO:0048009)2.44646008
111heme transport (GO:0015886)2.44414898
112transepithelial transport (GO:0070633)2.44362460
113synaptic vesicle docking involved in exocytosis (GO:0016081)2.43974486
114protein localization to cilium (GO:0061512)2.43942885
115double-strand break repair via homologous recombination (GO:0000724)2.42669293
116recombinational repair (GO:0000725)2.41953942
117muscle filament sliding (GO:0030049)2.41871936
118actin-myosin filament sliding (GO:0033275)2.41871936
119maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.41598483
120regulation of DNA endoreduplication (GO:0032875)2.41481898
121asymmetric protein localization (GO:0008105)2.41309593
122regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.40239624
123regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.39676928
124dendritic spine organization (GO:0097061)2.39390630
125dopamine transport (GO:0015872)2.38983191
126negative regulation of axon extension involved in axon guidance (GO:0048843)2.38916656
127cell communication involved in cardiac conduction (GO:0086065)2.38635035
128regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.38472062
129regulation of mitotic spindle checkpoint (GO:1903504)2.38472062
130regulation of cell communication by electrical coupling (GO:0010649)2.37666267
131proline transport (GO:0015824)2.37509950
132negative regulation of neurotransmitter secretion (GO:0046929)2.37198107
133cilium morphogenesis (GO:0060271)2.36881846
134hippo signaling (GO:0035329)2.36822924
135negative regulation of membrane potential (GO:0045837)2.36461340
136plasma membrane repair (GO:0001778)2.36047090
137presynaptic membrane organization (GO:0097090)2.35757499
138myofibril assembly (GO:0030239)2.33248145
139embryonic foregut morphogenesis (GO:0048617)2.32935312
140regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.32796390
141sarcomere organization (GO:0045214)2.32651200
142actin-mediated cell contraction (GO:0070252)2.32544175
143protein targeting to Golgi (GO:0000042)2.31705524
144regulation of potassium ion transmembrane transporter activity (GO:1901016)2.31113578
145regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.29400286
146regulation of membrane repolarization (GO:0060306)2.28831630
147regulation of synaptic vesicle transport (GO:1902803)2.28486853
148regulation of cofactor metabolic process (GO:0051193)2.28103677
149regulation of coenzyme metabolic process (GO:0051196)2.28103677
150regulation of sarcomere organization (GO:0060297)2.27909316
151sarcoplasmic reticulum calcium ion transport (GO:0070296)2.27198465
152dendrite morphogenesis (GO:0048813)2.26973338
153myelin maintenance (GO:0043217)2.26923456
154apical protein localization (GO:0045176)2.26120986
155membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.25926407
156neural tube formation (GO:0001841)2.25762799
157neuron recognition (GO:0008038)2.25563129
158chromatin remodeling at centromere (GO:0031055)2.25289828
159regulation of short-term neuronal synaptic plasticity (GO:0048172)2.24326403
160exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.24090940
161insulin secretion (GO:0030073)2.24028192
162developmental pigmentation (GO:0048066)2.23870544
163positive regulation of cardiac muscle cell differentiation (GO:2000727)2.23852976
164response to X-ray (GO:0010165)2.23670466
165ER overload response (GO:0006983)2.23250023
166chondrocyte development (GO:0002063)2.22824350
167body morphogenesis (GO:0010171)2.22294131
168SMAD protein complex assembly (GO:0007183)2.22035188
169relaxation of cardiac muscle (GO:0055119)2.20647266
170synaptic vesicle exocytosis (GO:0016079)2.20240919
171corticosteroid receptor signaling pathway (GO:0031958)2.19838594
172heart contraction (GO:0060047)2.19743919
173heart process (GO:0003015)2.19743919
174positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.19029416
175cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.17432100
176regulation of acyl-CoA biosynthetic process (GO:0050812)2.17216313
177cardiac muscle contraction (GO:0060048)2.16802381
178positive regulation of potassium ion transport (GO:0043268)2.15696025
179regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.14808240
180regulation of neuron migration (GO:2001222)2.14292930
181organelle transport along microtubule (GO:0072384)2.14059740
182mitotic sister chromatid cohesion (GO:0007064)2.12997551
183cell communication by electrical coupling (GO:0010644)2.12549046
184localization within membrane (GO:0051668)2.12056604
185glutamate secretion (GO:0014047)2.11740721
186regulation of potassium ion transmembrane transport (GO:1901379)2.11690509
187regulation of secondary heart field cardioblast proliferation (GO:0003266)2.11069493
188regulation of cardioblast proliferation (GO:0003264)2.11069493
189actomyosin structure organization (GO:0031032)2.09041576
190embryonic heart tube development (GO:0035050)2.08855888
191regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.08128396
192desmosome organization (GO:0002934)2.06818035
193presynaptic membrane assembly (GO:0097105)2.06799879

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RBPJ_22232070_ChIP-Seq_NCS_Mouse2.88838406
2CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.78666718
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.61141313
4WT1_19549856_ChIP-ChIP_CCG9911_Human2.47121973
5FLI1_27457419_Chip-Seq_LIVER_Mouse2.43530023
6SMAD_19615063_ChIP-ChIP_OVARY_Human2.42517815
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.25636209
8* POU3F2_20337985_ChIP-ChIP_501MEL_Human2.23305666
9GBX2_23144817_ChIP-Seq_PC3_Human2.18843785
10TCF3_18467660_ChIP-ChIP_MESCs_Mouse2.13157920
11* ZNF217_24962896_ChIP-Seq_MCF-7_Human2.12678697
12SALL1_21062744_ChIP-ChIP_HESCs_Human2.11150436
13FUS_26573619_Chip-Seq_HEK293_Human2.02637493
14OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.99273726
15PCGF2_27294783_Chip-Seq_ESCs_Mouse1.96456973
16CDX2_19796622_ChIP-Seq_MESCs_Mouse1.91590389
17GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.90659269
18IGF1R_20145208_ChIP-Seq_DFB_Human1.89361894
19ELK1_19687146_ChIP-ChIP_HELA_Human1.87910296
20EGR1_19374776_ChIP-ChIP_THP-1_Human1.84761878
21TP53_16413492_ChIP-PET_HCT116_Human1.84724422
22EZH2_27294783_Chip-Seq_NPCs_Mouse1.83301668
23ESR1_20079471_ChIP-ChIP_T-47D_Human1.77374161
24AR_21572438_ChIP-Seq_LNCaP_Human1.75869640
25GABP_17652178_ChIP-ChIP_JURKAT_Human1.75798024
26SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.74943021
27TAF15_26573619_Chip-Seq_HEK293_Human1.71988878
28SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.71664407
29EP300_21415370_ChIP-Seq_HL-1_Mouse1.70622676
30SUZ12_27294783_Chip-Seq_NPCs_Mouse1.70205597
31SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.69928063
32EZH2_22144423_ChIP-Seq_EOC_Human1.69131119
33PIAS1_25552417_ChIP-Seq_VCAP_Human1.68126479
34* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.66644941
35* SMAD4_21799915_ChIP-Seq_A2780_Human1.65519223
36P300_19829295_ChIP-Seq_ESCs_Human1.64435803
37SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.62647485
38NFE2_27457419_Chip-Seq_LIVER_Mouse1.62339469
39E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.61892626
40ZNF274_21170338_ChIP-Seq_K562_Hela1.61678510
41TRIM28_21343339_ChIP-Seq_HEK293_Human1.60366534
42EST1_17652178_ChIP-ChIP_JURKAT_Human1.54104722
43HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.53627437
44NANOG_18555785_Chip-Seq_ESCs_Mouse1.52766187
45UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.52516913
46SMAD3_21741376_ChIP-Seq_EPCs_Human1.52202613
47RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.51082965
48EWS_26573619_Chip-Seq_HEK293_Human1.50981837
49TOP2B_26459242_ChIP-Seq_MCF-7_Human1.50979390
50BCAT_22108803_ChIP-Seq_LS180_Human1.50481319
51ARNT_22903824_ChIP-Seq_MCF-7_Human1.49422871
52JARID2_20064375_ChIP-Seq_MESCs_Mouse1.49170984
53TP53_18474530_ChIP-ChIP_U2OS_Human1.48994994
54SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.48396623
55SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.48085722
56ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.48075789
57SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.47348797
58WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.46974439
59HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.46967781
60MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.46634110
61CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.45992370
62CTBP2_25329375_ChIP-Seq_LNCAP_Human1.42991723
63SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.42952657
64PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.42933667
65AHR_22903824_ChIP-Seq_MCF-7_Human1.42477889
66TCF4_18268006_ChIP-ChIP_LS174T_Human1.42475873
67YAP1_20516196_ChIP-Seq_MESCs_Mouse1.42309789
68CRX_20693478_ChIP-Seq_RETINA_Mouse1.42150326
69SOX2_19829295_ChIP-Seq_ESCs_Human1.41260260
70NANOG_19829295_ChIP-Seq_ESCs_Human1.41260260
71GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.40973700
72PCGF2_27294783_Chip-Seq_NPCs_Mouse1.40638232
73EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.40632685
74EZH2_18974828_ChIP-Seq_MESCs_Mouse1.39568751
75RNF2_18974828_ChIP-Seq_MESCs_Mouse1.39568751
76FOXM1_26456572_ChIP-Seq_MCF-7_Human1.38301958
77P53_22387025_ChIP-Seq_ESCs_Mouse1.38198190
78IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.37731020
79CBP_20019798_ChIP-Seq_JUKART_Human1.37731020
80PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.37469423
81* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.36695991
82VDR_22108803_ChIP-Seq_LS180_Human1.35925065
83NRF2_20460467_ChIP-Seq_MEFs_Mouse1.35918813
84NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.35918813
85STAT3_23295773_ChIP-Seq_U87_Human1.34346606
86CTBP1_25329375_ChIP-Seq_LNCAP_Human1.33954040
87CDX2_22108803_ChIP-Seq_LS180_Human1.33937003
88EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.32141897
89* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.32088793
90EZH2_27304074_Chip-Seq_ESCs_Mouse1.32074265
91SOX2_21211035_ChIP-Seq_LN229_Gbm1.29593872
92RARB_27405468_Chip-Seq_BRAIN_Mouse1.29452507
93SUZ12_18555785_Chip-Seq_ESCs_Mouse1.28635096
94CMYC_18555785_Chip-Seq_ESCs_Mouse1.28376828
95SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.28301493
96NR3C1_21868756_ChIP-Seq_MCF10A_Human1.26788390
97RXR_22108803_ChIP-Seq_LS180_Human1.26379555
98TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.25884776
99SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.25709980
100E2F1_18555785_Chip-Seq_ESCs_Mouse1.25689812
101P300_18555785_Chip-Seq_ESCs_Mouse1.25227735
102HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.24747189
103PADI4_21655091_ChIP-ChIP_MCF-7_Human1.24419939
104MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.24330149
105ISL1_27105846_Chip-Seq_CPCs_Mouse1.23796032
106NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.23208408
107TCF4_23295773_ChIP-Seq_U87_Human1.22653267
108OCT4_21477851_ChIP-Seq_ESCs_Mouse1.21858212
109POU5F1_16153702_ChIP-ChIP_HESCs_Human1.21550298
110FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.21354447
111BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.21084712
112NR3C1_23031785_ChIP-Seq_PC12_Mouse1.21032492
113ZFP57_27257070_Chip-Seq_ESCs_Mouse1.20933090
114STAT3_18555785_Chip-Seq_ESCs_Mouse1.19942599
115SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.18156649
116E2F4_17652178_ChIP-ChIP_JURKAT_Human1.17993975
117EED_16625203_ChIP-ChIP_MESCs_Mouse1.17889877
118RNF2_27304074_Chip-Seq_ESCs_Mouse1.17820830
119MTF2_20144788_ChIP-Seq_MESCs_Mouse1.17231023
120SMAD4_21741376_ChIP-Seq_EPCs_Human1.17207842
121* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.17152202
122AR_25329375_ChIP-Seq_VCAP_Human1.16014532
123RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.15242615
124* GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.14239573
125SOX2_18555785_Chip-Seq_ESCs_Mouse1.13993664
126* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.13419741
127CLOCK_20551151_ChIP-Seq_293T_Human1.13010146
128EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.12702684
129JARID2_20075857_ChIP-Seq_MESCs_Mouse1.12532726
130FOXA1_21572438_ChIP-Seq_LNCaP_Human1.11905544
131STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.11182815
132FLI1_21867929_ChIP-Seq_TH2_Mouse1.11061992
133DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.10374653
134ER_23166858_ChIP-Seq_MCF-7_Human1.09881766
135TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.09806956
136* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.09512218
137TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.09142950
138WT1_25993318_ChIP-Seq_PODOCYTE_Human1.09007891
139ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.08325234
140AR_19668381_ChIP-Seq_PC3_Human1.08271323
141OCT4_18555785_Chip-Seq_ESCs_Mouse1.07991677
142CTNNB1_20460455_ChIP-Seq_HCT116_Human1.06732103
143EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.06448344
144SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.05935779
145TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.05187101
146* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.05117008
147MYC_18940864_ChIP-ChIP_HL60_Human1.04938223
148FOXA1_25329375_ChIP-Seq_VCAP_Human1.04369556
149FOXA1_27270436_Chip-Seq_PROSTATE_Human1.04369556
150PRDM14_20953172_ChIP-Seq_ESCs_Human1.04227404
151RUNX2_22187159_ChIP-Seq_PCA_Human1.03802528
152CJUN_26792858_Chip-Seq_BT549_Human1.03120943
153TCF4_22108803_ChIP-Seq_LS180_Human1.02688724
154FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.02216135
155FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.02075668
156TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.02015378
157PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.01903954

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle4.22179863
2MP0003195_calcinosis3.87236967
3MP0002102_abnormal_ear_morphology3.30378018
4MP0000372_irregular_coat_pigmentation3.21963426
5MP0008877_abnormal_DNA_methylation2.94563577
6MP0002877_abnormal_melanocyte_morpholog2.48452508
7MP0002938_white_spotting2.44704899
8MP0009780_abnormal_chondrocyte_physiolo2.37009956
9MP0002009_preneoplasia2.35502822
10MP0004859_abnormal_synaptic_plasticity2.28277356
11MP0000516_abnormal_urinary_system2.24371476
12MP0005367_renal/urinary_system_phenotyp2.24371476
13MP0002254_reproductive_system_inflammat2.22960173
14MP0005075_abnormal_melanosome_morpholog2.12172913
15MP0004145_abnormal_muscle_electrophysio2.11282428
16MP0004084_abnormal_cardiac_muscle2.04891515
17MP0000013_abnormal_adipose_tissue2.03885843
18MP0002163_abnormal_gland_morphology1.99011802
19MP0008057_abnormal_DNA_replication1.98712688
20MP0005623_abnormal_meninges_morphology1.92680075
21MP0005379_endocrine/exocrine_gland_phen1.90081528
22MP0006054_spinal_hemorrhage1.83152400
23MP0003880_abnormal_central_pattern1.81295548
24MP0002837_dystrophic_cardiac_calcinosis1.80491657
25MP0000537_abnormal_urethra_morphology1.77905591
26MP0003787_abnormal_imprinting1.77742735
27MP0004215_abnormal_myocardial_fiber1.71800109
28MP0005253_abnormal_eye_physiology1.71431322
29MP0004036_abnormal_muscle_relaxation1.69992176
30MP0006072_abnormal_retinal_apoptosis1.68491233
31MP0008058_abnormal_DNA_repair1.67483077
32MP0005620_abnormal_muscle_contractility1.67432623
33MP0004270_analgesia1.66940146
34MP0001177_atelectasis1.65556999
35MP0002638_abnormal_pupillary_reflex1.64449157
36MP0002972_abnormal_cardiac_muscle1.63716516
37MP0002090_abnormal_vision1.60142159
38MP0003122_maternal_imprinting1.57888324
39MP0005551_abnormal_eye_electrophysiolog1.57311763
40MP0010678_abnormal_skin_adnexa1.49772242
41MP0003635_abnormal_synaptic_transmissio1.48043843
42MP0000569_abnormal_digit_pigmentation1.46912881
43MP0005220_abnormal_exocrine_pancreas1.45515599
44MP0003941_abnormal_skin_development1.44618046
45MP0005187_abnormal_penis_morphology1.41506998
46MP0002909_abnormal_adrenal_gland1.41298379
47MP0003300_gastrointestinal_ulcer1.39945443
48MP0005174_abnormal_tail_pigmentation1.39505473
49MP0004484_altered_response_of1.37423917
50MP0000647_abnormal_sebaceous_gland1.37096335
51MP0001346_abnormal_lacrimal_gland1.35392643
52MP0001299_abnormal_eye_distance/1.34286553
53MP0003121_genomic_imprinting1.33844434
54MP0005084_abnormal_gallbladder_morpholo1.31307253
55MP0005275_abnormal_skin_tensile1.30059132
56MP0005076_abnormal_cell_differentiation1.29396160
57MP0002063_abnormal_learning/memory/cond1.29389516
58MP0009053_abnormal_anal_canal1.28536587
59MP0003786_premature_aging1.28387010
60MP0003123_paternal_imprinting1.27304520
61MP0000751_myopathy1.26370647
62MP0010094_abnormal_chromosome_stability1.26229878
63MP0000778_abnormal_nervous_system1.26031493
64MP0005171_absent_coat_pigmentation1.25187728
65MP0005645_abnormal_hypothalamus_physiol1.25090596
66MP0002751_abnormal_autonomic_nervous1.25052169
67MP0004087_abnormal_muscle_fiber1.24718488
68MP0003950_abnormal_plasma_membrane1.23875120
69MP0006292_abnormal_olfactory_placode1.22916560
70MP0005408_hypopigmentation1.20140062
71MP0000003_abnormal_adipose_tissue1.20114525
72MP0010386_abnormal_urinary_bladder1.19844068
73MP0002234_abnormal_pharynx_morphology1.19750816
74MP0003718_maternal_effect1.19546452
75MP0009046_muscle_twitch1.19271200
76MP0001485_abnormal_pinna_reflex1.19253051
77MP0004272_abnormal_basement_membrane1.16938473
78MP0000749_muscle_degeneration1.16888252
79MP0004885_abnormal_endolymph1.15352998
80MP0002896_abnormal_bone_mineralization1.14401843
81MP0000613_abnormal_salivary_gland1.13408494
82MP0003119_abnormal_digestive_system1.12753735
83MP0001324_abnormal_eye_pigmentation1.10275019
84MP0001879_abnormal_lymphatic_vessel1.10212848
85MP0008872_abnormal_physiological_respon1.10164036
86MP0005330_cardiomyopathy1.10114301
87MP0004185_abnormal_adipocyte_glucose1.09906184
88MP0009745_abnormal_behavioral_response1.09073732
89MP0009250_abnormal_appendicular_skeleto1.07794246
90MP0004130_abnormal_muscle_cell1.07476793
91MP0003937_abnormal_limbs/digits/tail_de1.07349821
92MP0005646_abnormal_pituitary_gland1.05229737
93MP0002876_abnormal_thyroid_physiology1.05133399
94MP0002928_abnormal_bile_duct1.04318349
95MP0001944_abnormal_pancreas_morphology1.04133848
96MP0004085_abnormal_heartbeat1.04082350
97MP0002106_abnormal_muscle_physiology1.03840528
98MP0002736_abnormal_nociception_after1.03375969
99MP0010630_abnormal_cardiac_muscle1.01629250
100MP0006036_abnormal_mitochondrial_physio0.99902183
101MP0008775_abnormal_heart_ventricle0.97907879
102MP0000538_abnormal_urinary_bladder0.97318404
103MP0000015_abnormal_ear_pigmentation0.96861771
104MP0004233_abnormal_muscle_weight0.96832608
105MP0005395_other_phenotype0.96812771
106MP0004133_heterotaxia0.95518465
107MP0004147_increased_porphyrin_level0.94718861
108MP0009384_cardiac_valve_regurgitation0.93058423
109MP0003943_abnormal_hepatobiliary_system0.92685146
110MP0000733_abnormal_muscle_development0.91974919
111MP0006138_congestive_heart_failure0.91761903
112MP0005369_muscle_phenotype0.91389386
113MP0003935_abnormal_craniofacial_develop0.90572042
114MP0001984_abnormal_olfaction0.89059782
115MP0005248_abnormal_Harderian_gland0.88632372
116MP0003136_yellow_coat_color0.88285774
117MP0000467_abnormal_esophagus_morphology0.87853321
118MP0003646_muscle_fatigue0.87701655
119MP0009703_decreased_birth_body0.87494652
120MP0005385_cardiovascular_system_phenoty0.87468029
121MP0001544_abnormal_cardiovascular_syste0.87468029
122MP0003011_delayed_dark_adaptation0.86427765
123MP0003385_abnormal_body_wall0.85767155
124MP0003755_abnormal_palate_morphology0.85521309
125MP0001188_hyperpigmentation0.85347956
126MP0005332_abnormal_amino_acid0.84205578
127MP0002734_abnormal_mechanical_nocicepti0.83666117
128MP0004043_abnormal_pH_regulation0.83544097
129MP0002168_other_aberrant_phenotype0.83435280
130MP0000631_abnormal_neuroendocrine_gland0.83289859
131MP0003283_abnormal_digestive_organ0.82416173
132MP0003567_abnormal_fetal_cardiomyocyte0.81006644
133MP0001486_abnormal_startle_reflex0.80715915
134MP0003890_abnormal_embryonic-extraembry0.80524733
135MP0010352_gastrointestinal_tract_polyps0.79884999
136MP0005388_respiratory_system_phenotype0.79816738
137MP0002133_abnormal_respiratory_system0.79816738
138MP0002098_abnormal_vibrissa_morphology0.79562436
139MP0009697_abnormal_copulation0.79403890
140MP0003221_abnormal_cardiomyocyte_apopto0.78693491
141MP0002095_abnormal_skin_pigmentation0.78402829
142MP0005386_behavior/neurological_phenoty0.78242677
143MP0004924_abnormal_behavior0.78242677
144MP0008007_abnormal_cellular_replicative0.77440499
145MP0002693_abnormal_pancreas_physiology0.77184773
146MP0000427_abnormal_hair_cycle0.76353296
147MP0000762_abnormal_tongue_morphology0.75971477
148MP0008569_lethality_at_weaning0.75319448
149MP0001968_abnormal_touch/_nociception0.74540899
150MP0001756_abnormal_urination0.74406303
151MP0003252_abnormal_bile_duct0.73873325
152MP0002282_abnormal_trachea_morphology0.73827539
153MP0001764_abnormal_homeostasis0.73185342
154MP0000383_abnormal_hair_follicle0.73005482
155MP0002064_seizures0.72294458
156MP0001929_abnormal_gametogenesis0.71935818
157MP0000639_abnormal_adrenal_gland0.71266541
158MP0003115_abnormal_respiratory_system0.71161888
159MP0002796_impaired_skin_barrier0.70815696
160MP0003828_pulmonary_edema0.70625143
161MP0001784_abnormal_fluid_regulation0.70319589
162MP0009672_abnormal_birth_weight0.70071186
163MP0004811_abnormal_neuron_physiology0.69772699
164MP0003137_abnormal_impulse_conducting0.69399435

Predicted human phenotypes

RankGene SetZ-score
1Exercise-induced muscle cramps (HP:0003710)3.79182516
2Papilledema (HP:0001085)3.70341807
3Intestinal atresia (HP:0011100)3.50701501
4Hypothermia (HP:0002045)3.48830084
5Neoplasm of the adrenal cortex (HP:0100641)3.48371388
6Hypoplasia of the fovea (HP:0007750)3.29185860
7Aplasia/Hypoplasia of the fovea (HP:0008060)3.29185860
8Right ventricular cardiomyopathy (HP:0011663)3.07221436
9Hyperinsulinemic hypoglycemia (HP:0000825)3.02305859
10Hypoglycemic seizures (HP:0002173)2.99807120
11Neoplasm of the adrenal gland (HP:0100631)2.95552894
12Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.87989972
13Degeneration of the lateral corticospinal tracts (HP:0002314)2.87989972
14Abnormality of the fovea (HP:0000493)2.85886449
15Methylmalonic acidemia (HP:0002912)2.85690372
16Muscle hypertrophy of the lower extremities (HP:0008968)2.84652962
17Hypoglycemic coma (HP:0001325)2.84334902
18Pancreatic cysts (HP:0001737)2.82778549
19Subacute progressive viral hepatitis (HP:0006572)2.80458288
20Calf muscle hypertrophy (HP:0008981)2.76338095
21Papillary thyroid carcinoma (HP:0002895)2.73544541
22Asymmetry of the thorax (HP:0001555)2.72490802
23Progressive macrocephaly (HP:0004481)2.68817250
24Sudden death (HP:0001699)2.66139511
25Ependymoma (HP:0002888)2.61532896
26Exercise-induced myalgia (HP:0003738)2.60987658
27True hermaphroditism (HP:0010459)2.58887536
28Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.58189430
29Subaortic stenosis (HP:0001682)2.58013936
30Abnormality of the left ventricular outflow tract (HP:0011103)2.58013936
31Pancreatic fibrosis (HP:0100732)2.54324640
32Abnormality of the pancreatic islet cells (HP:0006476)2.50066189
33Abnormality of endocrine pancreas physiology (HP:0012093)2.50066189
34Ketoacidosis (HP:0001993)2.47956022
35Muscle fiber inclusion bodies (HP:0100299)2.47405323
36Megalencephaly (HP:0001355)2.45849956
37Abnormality of the astrocytes (HP:0100707)2.43656471
38Astrocytoma (HP:0009592)2.43656471
39Shoulder girdle muscle weakness (HP:0003547)2.42849064
40Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.41755300
41Nemaline bodies (HP:0003798)2.39888844
42Abnormality of the labia minora (HP:0012880)2.38439905
43Abnormality of vitamin B metabolism (HP:0004340)2.35519194
44Breast carcinoma (HP:0003002)2.34731346
45Thyroiditis (HP:0100646)2.34101010
46Large for gestational age (HP:0001520)2.32661720
47Aplasia/Hypoplasia of the macula (HP:0008059)2.32545300
48Glioma (HP:0009733)2.31806899
49Abnormality of the calf musculature (HP:0001430)2.31494950
50Type 1 muscle fiber predominance (HP:0003803)2.31070534
51Abnormality of midbrain morphology (HP:0002418)2.25265519
52Molar tooth sign on MRI (HP:0002419)2.25265519
53Congenital stationary night blindness (HP:0007642)2.25078937
54Nephronophthisis (HP:0000090)2.23760190
55Medial flaring of the eyebrow (HP:0010747)2.18258519
56Ankyloglossia (HP:0010296)2.18108025
57Hypoplastic labia majora (HP:0000059)2.17756849
58Acute necrotizing encephalopathy (HP:0006965)2.17139894
59Short 1st metacarpal (HP:0010034)2.16791766
60Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.16791766
61Tongue fasciculations (HP:0001308)2.16760480
62Abnormality of the renal cortex (HP:0011035)2.16122175
63Hyperthyroidism (HP:0000836)2.15487703
64Progressive inability to walk (HP:0002505)2.14958932
65Patchy hypopigmentation of hair (HP:0011365)2.14438355
66Hyporeflexia of lower limbs (HP:0002600)2.14434694
67Aplasia/Hypoplasia affecting the retina (HP:0008061)2.14298678
68Overgrowth (HP:0001548)2.14071003
69Focal motor seizures (HP:0011153)2.13491984
70Abnormality of the corticospinal tract (HP:0002492)2.12258483
71Methylmalonic aciduria (HP:0012120)2.10277640
72Abnormality of aspartate family amino acid metabolism (HP:0010899)2.08938870
73Abnormality of chromosome stability (HP:0003220)2.07997132
74Excessive salivation (HP:0003781)2.07947469
75Drooling (HP:0002307)2.07947469
76Acute encephalopathy (HP:0006846)2.07580130
77Rectal prolapse (HP:0002035)2.07238728
78Conjunctival hamartoma (HP:0100780)2.07077181
79Disproportionate short-trunk short stature (HP:0003521)2.06236097
80Rimmed vacuoles (HP:0003805)2.06025083
81Thyroid carcinoma (HP:0002890)2.04555421
82Visual hallucinations (HP:0002367)2.04348460
83Increased CSF lactate (HP:0002490)2.02475386
84Termporal pattern (HP:0011008)2.01884523
85Insidious onset (HP:0003587)2.01884523
86Abnormality of methionine metabolism (HP:0010901)1.99744418
87Abnormality of the renal medulla (HP:0100957)1.98470900
88Sensory axonal neuropathy (HP:0003390)1.98453799
89Macroorchidism (HP:0000053)1.98081966
90Colon cancer (HP:0003003)1.97489788
91Sleep apnea (HP:0010535)1.97048438
92Hemiparesis (HP:0001269)1.96082751
93Symptomatic seizures (HP:0011145)1.95664597
94Scapular winging (HP:0003691)1.94678202
95Inappropriate behavior (HP:0000719)1.94540317
96Atonic seizures (HP:0010819)1.94331178
97Hyperkalemia (HP:0002153)1.93856265
98Abnormality of the labia majora (HP:0012881)1.93576055
99Hypomagnesemia (HP:0002917)1.92397365
100Abnormality of the musculature of the pelvis (HP:0001469)1.91960724
101Abnormality of the hip-girdle musculature (HP:0001445)1.91960724
102Pelvic girdle muscle weakness (HP:0003749)1.91889772
103Pancreatic islet-cell hyperplasia (HP:0004510)1.91067487
104Broad-based gait (HP:0002136)1.90452370
105Cutaneous melanoma (HP:0012056)1.88575268
106Abolished electroretinogram (ERG) (HP:0000550)1.88405930
107Furrowed tongue (HP:0000221)1.86736400
108Abnormal biliary tract morphology (HP:0012440)1.86567933
109Mitochondrial inheritance (HP:0001427)1.86277705
110Gaze-evoked nystagmus (HP:0000640)1.86196909
111White forelock (HP:0002211)1.84319133
112Absent eyebrow (HP:0002223)1.84248265
113Abnormality of the vitamin B12 metabolism (HP:0004341)1.84030940
114Insulin-resistant diabetes mellitus (HP:0000831)1.83719328
115Congenital malformation of the right heart (HP:0011723)1.83160998
116Double outlet right ventricle (HP:0001719)1.83160998
117Lower limb asymmetry (HP:0100559)1.83040278
118Aplasia/Hypoplasia of the uvula (HP:0010293)1.82634827
119Abnormal pancreas size (HP:0012094)1.82309064
120Renal cortical cysts (HP:0000803)1.82052419
121Curly hair (HP:0002212)1.81987600
122Resting tremor (HP:0002322)1.81827470
123Neoplasm of the peripheral nervous system (HP:0100007)1.81509184
124Aplasia/Hypoplasia of the tongue (HP:0010295)1.80959220
125Delayed gross motor development (HP:0002194)1.79225803
126Albinism (HP:0001022)1.78979464
127Genital tract atresia (HP:0001827)1.77597703
128Meningioma (HP:0002858)1.77163775
129Rhabdomyosarcoma (HP:0002859)1.76914618
130Atrial fibrillation (HP:0005110)1.75481947
131Gastrointestinal atresia (HP:0002589)1.75073167
132Hepatic necrosis (HP:0002605)1.74561688
133Abnormality of the nasal septum (HP:0000419)1.74386558
134Limb-girdle muscle weakness (HP:0003325)1.73862809
135Biliary tract neoplasm (HP:0100574)1.73817329
136Renal hypoplasia (HP:0000089)1.73686319
137Abnormality of oral frenula (HP:0000190)1.73024125
138Lip pit (HP:0100267)1.72960740
139Muscular hypotonia of the trunk (HP:0008936)1.72476117
140Muscle fibrillation (HP:0010546)1.70390332
141Abnormality of the 1st metacarpal (HP:0010009)1.70317423
142EMG: myopathic abnormalities (HP:0003458)1.69923104
143Absent frontal sinuses (HP:0002688)1.69448752
144Adrenal hypoplasia (HP:0000835)1.68749886
145Pheochromocytoma (HP:0002666)1.68508063
146Bronchomalacia (HP:0002780)1.67620149
147Volvulus (HP:0002580)1.67033383
148Abnormality of macular pigmentation (HP:0008002)1.66954455
149Abnormality of the shoulder girdle musculature (HP:0001435)1.66809344
150Ovarian neoplasm (HP:0100615)1.66477105
151Hyperglycemia (HP:0003074)1.66425270
152Hepatoblastoma (HP:0002884)1.66378668
153Protruding tongue (HP:0010808)1.66147883
154Primary atrial arrhythmia (HP:0001692)1.66028512
155Short hallux (HP:0010109)1.65646680
156Congenital sensorineural hearing impairment (HP:0008527)1.64871730
157Long clavicles (HP:0000890)1.64836185
158Lower limb amyotrophy (HP:0007210)1.64828738
159Aortic aneurysm (HP:0004942)1.64494476
160Abnormality of the right ventricle (HP:0001707)1.64101792
161Increased hepatocellular lipid droplets (HP:0006565)1.64049231
162Meckel diverticulum (HP:0002245)1.64048163
163Hepatocellular necrosis (HP:0001404)1.63672140
164Hypoproteinemia (HP:0003075)1.63504736
165Hamartoma of the eye (HP:0010568)1.63373875
166Aqueductal stenosis (HP:0002410)1.62992653
167Abnormality of urine glucose concentration (HP:0011016)1.62885286
168Glycosuria (HP:0003076)1.62885286
169Adenoma sebaceum (HP:0009720)1.62343629
170Angiofibromas (HP:0010615)1.62343629
171Congenital primary aphakia (HP:0007707)1.62158689
172Bifid tongue (HP:0010297)1.61946853
173Barrel-shaped chest (HP:0001552)1.61707634
174Mildly elevated creatine phosphokinase (HP:0008180)1.61277246
175Prolonged QT interval (HP:0001657)1.60916627
176Hematochezia (HP:0002573)1.59290634
177Vertebral arch anomaly (HP:0008438)1.58591129
178Difficulty running (HP:0009046)1.57606441
179Buphthalmos (HP:0000557)1.56180121
180Long nose (HP:0003189)1.56052606
181Bladder carcinoma (HP:0002862)1.55767536
182Bladder neoplasm (HP:0009725)1.55767536
183Labial hypoplasia (HP:0000066)1.54784207
184Transitional cell carcinoma of the bladder (HP:0006740)1.54694206
185Neoplasm of the thyroid gland (HP:0100031)1.54535720
186Neck muscle weakness (HP:0000467)1.54520473
187Enlarged penis (HP:0000040)1.53735491
188Hypoplastic ischia (HP:0003175)1.52600849
189Obstructive sleep apnea (HP:0002870)1.51715061
190Abnormality of chromosome segregation (HP:0002916)1.49635278
191Proximal amyotrophy (HP:0007126)1.49572631

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIM284.38501932
2FRK4.35588565
3ERBB33.66605633
4WNK32.93693268
5ACVR1B2.80005657
6BMPR1B2.73303378
7EIF2AK32.66085880
8TNIK2.53923549
9MAP3K22.45755049
10SIK32.41415830
11NTRK32.26446346
12MAP4K22.26311466
13DMPK2.23362727
14SCYL22.21309340
15OBSCN2.18533304
16LMTK22.05904771
17FGFR22.01955684
18PLK22.01079532
19EIF2AK12.00705181
20FER1.74827818
21MINK11.74147780
22FGFR31.66893948
23MKNK11.62947200
24GRK11.61879877
25MARK11.60748551
26EPHA41.59783688
27NEK11.59552077
28WEE11.58617499
29STK391.57398161
30LATS11.47412475
31MAP3K41.45648584
32TTN1.44429377
33BCR1.40970522
34PKN21.38811280
35KSR11.33284589
36STK241.31621941
37SGK21.26228448
38PIK3CA1.24794695
39LIMK11.21118022
40MAP3K91.20995734
41MKNK21.20760402
42KSR21.20663862
43CSNK1G11.15593334
44PAK31.14617831
45PLK31.13052663
46PDGFRA1.09225128
47RET1.06066481
48UHMK11.05965194
49PHKG11.03834968
50PHKG21.03834968
51OXSR11.03732517
52BUB11.02206242
53CSNK1G21.01240668
54INSRR1.01053727
55DAPK20.99337443
56MAP2K70.99228671
57PRKD30.98867434
58PLK40.96516801
59NLK0.96199331
60SGK2230.95963430
61SGK4940.95963430
62CASK0.95468328
63PTK60.94752845
64SGK30.93814675
65CSNK1G30.93281378
66ADRBK20.90233792
67BMPR20.90118199
68PINK10.89780815
69WNK40.89438762
70ALK0.89309652
71TRPM70.86653855
72WNK10.85844612
73FGFR10.85501122
74MST40.83058233
75BRSK20.81288295
76MAPK130.80676972
77SGK10.80632926
78TAF10.79991877
79NUAK10.79612734
80DYRK1A0.77349641
81TGFBR10.77049165
82MAP2K40.76036840
83SRPK10.75989207
84MYLK0.75907073
85NTRK10.74732939
86PNCK0.73184733
87MAP3K120.71463334
88TSSK60.70375610
89ROCK10.70157646
90EIF2AK20.69929455
91CSNK1A1L0.69198715
92AKT30.68276148
93PDGFRB0.67743485
94HIPK20.67698206
95CDK60.67524473
96ZAK0.66251060
97PDK30.65496910
98PDK40.65496910
99TYRO30.65042433
100CDC70.62919193
101PRKCE0.60090871
102CDK50.59941428
103PLK10.58499194
104EPHA30.57990813
105STK30.57690578
106NEK90.53950073
107PTK20.51793027
108TGFBR20.51344659
109CDC42BPA0.51134855
110STK100.50992436
111PRKCG0.50566054
112VRK20.47526631
113EPHB20.47203567
114ADRBK10.46621138
115TTK0.46548177
116CDK140.46248090
117MUSK0.45076978
118PTK2B0.44983619
119YES10.44773822
120CAMK2A0.43392872
121PRKCI0.42117510
122VRK10.41240980
123PRKCH0.40027326
124PBK0.39565152
125MELK0.39348920
126STK38L0.39183692
127FGR0.39070135
128NEK60.38112405
129MAP2K10.37997168
130CAMK2D0.37838519
131TESK10.37798358
132PASK0.37591467
133STK160.36863501
134RPS6KB10.36576391
135FES0.35481954
136ERBB40.35366710
137CAMK2B0.35037314
138PDK20.34935257
139* ATM0.33644259
140RPS6KA30.33362619
141CSNK1A10.29934892
142GRK50.29706317
143BRSK10.29116886
144FLT30.28745182
145TIE10.28161030
146CSNK1D0.26738005
147ROCK20.26463383
148PRKAA20.24444137
149CDK30.22394386
150GSK3A0.21744246
151PRKG10.20905045
152PRKAA10.20879218

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030604.29431751
2Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.35630040
3Maturity onset diabetes of the young_Homo sapiens_hsa049503.26332828
4Proteasome_Homo sapiens_hsa030502.81623378
5Propanoate metabolism_Homo sapiens_hsa006402.78251408
6Non-homologous end-joining_Homo sapiens_hsa034502.66907703
7Vitamin B6 metabolism_Homo sapiens_hsa007502.63934036
8Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.41882209
9Butanoate metabolism_Homo sapiens_hsa006502.31750360
10* Long-term potentiation_Homo sapiens_hsa047202.08999409
11Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.99427402
12Basal transcription factors_Homo sapiens_hsa030221.95092994
13Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.91472467
14Fatty acid elongation_Homo sapiens_hsa000621.86847676
15Steroid biosynthesis_Homo sapiens_hsa001001.79734030
16Homologous recombination_Homo sapiens_hsa034401.77978315
17Olfactory transduction_Homo sapiens_hsa047401.67869858
18Fanconi anemia pathway_Homo sapiens_hsa034601.65181146
19Renin secretion_Homo sapiens_hsa049241.63300277
20Circadian entrainment_Homo sapiens_hsa047131.62304280
21Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.60387557
22* Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.59041565
23Phototransduction_Homo sapiens_hsa047441.58658936
24RNA degradation_Homo sapiens_hsa030181.57460082
25* Dopaminergic synapse_Homo sapiens_hsa047281.57424904
26Gastric acid secretion_Homo sapiens_hsa049711.56671804
27Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.51227596
28Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.50687378
29Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.49305848
30Insulin secretion_Homo sapiens_hsa049111.49268068
31Glioma_Homo sapiens_hsa052141.48400557
32* Amphetamine addiction_Homo sapiens_hsa050311.47273600
33Dilated cardiomyopathy_Homo sapiens_hsa054141.46279984
34Selenocompound metabolism_Homo sapiens_hsa004501.44356459
35Type II diabetes mellitus_Homo sapiens_hsa049301.41346389
36* Oxytocin signaling pathway_Homo sapiens_hsa049211.40767212
37Long-term depression_Homo sapiens_hsa047301.40380715
38Cholinergic synapse_Homo sapiens_hsa047251.40123447
39Caffeine metabolism_Homo sapiens_hsa002321.38314461
40Dorso-ventral axis formation_Homo sapiens_hsa043201.36569753
41Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.36496354
42Sulfur metabolism_Homo sapiens_hsa009201.36085844
43Adherens junction_Homo sapiens_hsa045201.35494333
44Nitrogen metabolism_Homo sapiens_hsa009101.35206827
45Renal cell carcinoma_Homo sapiens_hsa052111.34796143
46Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.34091145
47Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.31996140
48* cGMP-PKG signaling pathway_Homo sapiens_hsa040221.31818504
49Endometrial cancer_Homo sapiens_hsa052131.27460002
50Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.25836542
51Morphine addiction_Homo sapiens_hsa050321.25685090
52Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.25415544
53Salivary secretion_Homo sapiens_hsa049701.25389457
54Tight junction_Homo sapiens_hsa045301.25373473
55Estrogen signaling pathway_Homo sapiens_hsa049151.23383106
56Melanogenesis_Homo sapiens_hsa049161.23308780
57Axon guidance_Homo sapiens_hsa043601.22974497
58Oxidative phosphorylation_Homo sapiens_hsa001901.22156541
59* Focal adhesion_Homo sapiens_hsa045101.22089409
60GABAergic synapse_Homo sapiens_hsa047271.20410239
61Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.20283477
62Glutamatergic synapse_Homo sapiens_hsa047241.20017169
63* Oocyte meiosis_Homo sapiens_hsa041141.20003312
64Mismatch repair_Homo sapiens_hsa034301.18108257
65Gap junction_Homo sapiens_hsa045401.17779043
66Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.17612632
67Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.16417492
68Tryptophan metabolism_Homo sapiens_hsa003801.15461201
69Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.14843899
70GnRH signaling pathway_Homo sapiens_hsa049121.13935368
71Peroxisome_Homo sapiens_hsa041461.13520254
72Collecting duct acid secretion_Homo sapiens_hsa049661.11348407
73ErbB signaling pathway_Homo sapiens_hsa040121.10398483
74Aldosterone synthesis and secretion_Homo sapiens_hsa049251.10296475
75Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.08399787
76Nicotine addiction_Homo sapiens_hsa050331.08384592
77Vibrio cholerae infection_Homo sapiens_hsa051101.05978167
78Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.03756650
79* Hippo signaling pathway_Homo sapiens_hsa043901.02539124
80mTOR signaling pathway_Homo sapiens_hsa041501.01816410
81Synaptic vesicle cycle_Homo sapiens_hsa047211.01056043
82Wnt signaling pathway_Homo sapiens_hsa043101.01020216
83Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.00809116
84Phosphatidylinositol signaling system_Homo sapiens_hsa040701.00212773
85Ether lipid metabolism_Homo sapiens_hsa005650.99732895
86Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.98971435
87Serotonergic synapse_Homo sapiens_hsa047260.98705929
88Calcium signaling pathway_Homo sapiens_hsa040200.98283360
89Fatty acid metabolism_Homo sapiens_hsa012120.98271493
90* Vascular smooth muscle contraction_Homo sapiens_hsa042700.97911872
91* cAMP signaling pathway_Homo sapiens_hsa040240.97879380
92RNA polymerase_Homo sapiens_hsa030200.97111775
93Fatty acid degradation_Homo sapiens_hsa000710.95321125
94Prostate cancer_Homo sapiens_hsa052150.95044300
95Regulation of autophagy_Homo sapiens_hsa041400.93995993
96beta-Alanine metabolism_Homo sapiens_hsa004100.92911082
97TGF-beta signaling pathway_Homo sapiens_hsa043500.92308067
98Glucagon signaling pathway_Homo sapiens_hsa049220.92222003
99* Proteoglycans in cancer_Homo sapiens_hsa052050.92210256
100Thyroid cancer_Homo sapiens_hsa052160.91591025
101Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.90708219
102Pentose and glucuronate interconversions_Homo sapiens_hsa000400.90280942
103Pancreatic cancer_Homo sapiens_hsa052120.90014416
104Primary bile acid biosynthesis_Homo sapiens_hsa001200.89831404
105Pancreatic secretion_Homo sapiens_hsa049720.89778279
106Thyroid hormone synthesis_Homo sapiens_hsa049180.88988447
107Neurotrophin signaling pathway_Homo sapiens_hsa047220.88712112
108Colorectal cancer_Homo sapiens_hsa052100.88423657
109MicroRNAs in cancer_Homo sapiens_hsa052060.88094748
110Cysteine and methionine metabolism_Homo sapiens_hsa002700.87517033
111Cocaine addiction_Homo sapiens_hsa050300.86743868
112Thyroid hormone signaling pathway_Homo sapiens_hsa049190.86272363
113Melanoma_Homo sapiens_hsa052180.85993388
114RNA transport_Homo sapiens_hsa030130.85639261
115Glutathione metabolism_Homo sapiens_hsa004800.85402045
116Non-small cell lung cancer_Homo sapiens_hsa052230.84714410
117Taste transduction_Homo sapiens_hsa047420.84054473
118Pyruvate metabolism_Homo sapiens_hsa006200.83249450
119Central carbon metabolism in cancer_Homo sapiens_hsa052300.82078539
120VEGF signaling pathway_Homo sapiens_hsa043700.81937617
121Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.81149055
122Linoleic acid metabolism_Homo sapiens_hsa005910.81112760
123Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.81042731
124FoxO signaling pathway_Homo sapiens_hsa040680.80772157
125Parkinsons disease_Homo sapiens_hsa050120.79853868
126Prolactin signaling pathway_Homo sapiens_hsa049170.79242109
127Retinol metabolism_Homo sapiens_hsa008300.79047614
128Leukocyte transendothelial migration_Homo sapiens_hsa046700.78665464
129Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.78424256
130Folate biosynthesis_Homo sapiens_hsa007900.77187570
131One carbon pool by folate_Homo sapiens_hsa006700.76560811
132Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.74684198
133Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.74454916
134Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.74249969
135ECM-receptor interaction_Homo sapiens_hsa045120.74178471
136SNARE interactions in vesicular transport_Homo sapiens_hsa041300.73973209
137* Alcoholism_Homo sapiens_hsa050340.73394405
138Sphingolipid metabolism_Homo sapiens_hsa006000.72662217
139Choline metabolism in cancer_Homo sapiens_hsa052310.72473525
140Rap1 signaling pathway_Homo sapiens_hsa040150.72249409
141Circadian rhythm_Homo sapiens_hsa047100.72033501
142Cardiac muscle contraction_Homo sapiens_hsa042600.71901462
143* Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.71781324
144AMPK signaling pathway_Homo sapiens_hsa041520.71459614
145Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.70978478
146MAPK signaling pathway_Homo sapiens_hsa040100.70474145
147Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.70155785
148* Insulin signaling pathway_Homo sapiens_hsa049100.70126388
149Chronic myeloid leukemia_Homo sapiens_hsa052200.70058204
150Type I diabetes mellitus_Homo sapiens_hsa049400.69738537
151Nucleotide excision repair_Homo sapiens_hsa034200.69651016
152Ras signaling pathway_Homo sapiens_hsa040140.69424609
153Sphingolipid signaling pathway_Homo sapiens_hsa040710.67938083
154Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.67404252
155p53 signaling pathway_Homo sapiens_hsa041150.67147919
156AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.67107172
157Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.66567544
158Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.66327935
159* Regulation of actin cytoskeleton_Homo sapiens_hsa048100.66045455
160* Platelet activation_Homo sapiens_hsa046110.65181357
161Chemical carcinogenesis_Homo sapiens_hsa052040.65150065
162Metabolic pathways_Homo sapiens_hsa011000.64816816
163Purine metabolism_Homo sapiens_hsa002300.64672949
164Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.64359227
165alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.63935486
166Viral myocarditis_Homo sapiens_hsa054160.63597989
167Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.59522574
168Mineral absorption_Homo sapiens_hsa049780.58682545
169Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.58077102
170Hedgehog signaling pathway_Homo sapiens_hsa043400.55261248
171Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.54740253
1722-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.53451667
173Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.52533666
174Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.50885084
175Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.49288269
176Steroid hormone biosynthesis_Homo sapiens_hsa001400.47732948
177Alzheimers disease_Homo sapiens_hsa050100.46624747
178N-Glycan biosynthesis_Homo sapiens_hsa005100.46183805
179Cell cycle_Homo sapiens_hsa041100.45165316
180ABC transporters_Homo sapiens_hsa020100.44892061
181Fat digestion and absorption_Homo sapiens_hsa049750.39522836
182Huntingtons disease_Homo sapiens_hsa050160.37462116
183Starch and sucrose metabolism_Homo sapiens_hsa005000.37106987
184Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.36341097
185Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.33922328
186Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.33881980

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