PPP1R11

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a specific inhibitor of protein phosphatase-1 (PP1) with a differential sensitivity toward the metal-independent and metal-dependent forms of PP1. The gene is located within the major histocompatibility complex class I region on chromosome 6. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sperm motility (GO:0030317)7.78739541
2cell wall macromolecule catabolic process (GO:0016998)7.21629780
3cell wall macromolecule metabolic process (GO:0044036)7.21629780
4fusion of sperm to egg plasma membrane (GO:0007342)7.01943258
5acrosome reaction (GO:0007340)6.94995250
6acrosome assembly (GO:0001675)6.77112307
7sperm-egg recognition (GO:0035036)6.43240669
8epithelial cilium movement (GO:0003351)6.22243209
9binding of sperm to zona pellucida (GO:0007339)5.99722117
10regulation of cilium movement (GO:0003352)5.79166210
11multicellular organism reproduction (GO:0032504)5.70318002
12axonemal dynein complex assembly (GO:0070286)5.69715818
13cell-cell recognition (GO:0009988)5.66748480
14spermatid development (GO:0007286)5.50210108
15plasma membrane fusion (GO:0045026)5.48444192
16cilium movement (GO:0003341)5.25419953
17motile cilium assembly (GO:0044458)5.21443565
18cilium or flagellum-dependent cell motility (GO:0001539)5.03623344
19sequestering of actin monomers (GO:0042989)4.96643511
20antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.94952474
21reproduction (GO:0000003)4.88486164
22negative regulation of cell killing (GO:0031342)4.86796640
23negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.86796640
24GTP biosynthetic process (GO:0006183)4.48236549
25mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.42157280
26mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.34281271
27spermatid nucleus differentiation (GO:0007289)4.25641871
28chaperone-mediated protein transport (GO:0072321)4.21017709
29energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)4.20279716
30ATP hydrolysis coupled proton transport (GO:0015991)4.20279716
31protein neddylation (GO:0045116)4.18676753
32ATP synthesis coupled proton transport (GO:0015986)4.15819513
33energy coupled proton transport, down electrochemical gradient (GO:0015985)4.15819513
34single fertilization (GO:0007338)4.13539287
35neutrophil activation involved in immune response (GO:0002283)4.09762319
36sperm capacitation (GO:0048240)4.09313673
37antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.05427742
38negative regulation of inclusion body assembly (GO:0090084)4.04108473
39microtubule depolymerization (GO:0007019)4.03051054
40protein complex biogenesis (GO:0070271)4.02993750
41calcium ion-dependent exocytosis (GO:0017156)3.99177894
42nucleoside diphosphate phosphorylation (GO:0006165)3.95093244
43epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.94628889
44regulation of inclusion body assembly (GO:0090083)3.93541031
45mitochondrial respiratory chain complex assembly (GO:0033108)3.89486657
46protein localization to cilium (GO:0061512)3.88868512
47male meiosis (GO:0007140)3.82432542
48antigen processing and presentation of endogenous antigen (GO:0019883)3.78207011
49electron transport chain (GO:0022900)3.76259993
50respiratory electron transport chain (GO:0022904)3.75911353
51cullin deneddylation (GO:0010388)3.70204587
52UTP biosynthetic process (GO:0006228)3.69749039
53synaptonemal complex organization (GO:0070193)3.68586947
54DNA deamination (GO:0045006)3.67747877
55antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.60045306
56establishment of protein localization to mitochondrial membrane (GO:0090151)3.57503699
57viral protein processing (GO:0019082)3.56856156
58guanosine-containing compound biosynthetic process (GO:1901070)3.56327454
59mitochondrial respiratory chain complex I assembly (GO:0032981)3.50704420
60NADH dehydrogenase complex assembly (GO:0010257)3.50704420
61mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.50704420
62protein deneddylation (GO:0000338)3.50451835
63hydrogen ion transmembrane transport (GO:1902600)3.50192981
64spermatogenesis (GO:0007283)3.43505405
65purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.43458418
66male gamete generation (GO:0048232)3.42288254
67regulation of cellular amino acid metabolic process (GO:0006521)3.42235246
68regulation of microtubule-based movement (GO:0060632)3.35353355
69purine nucleoside triphosphate biosynthetic process (GO:0009145)3.35099161
70piRNA metabolic process (GO:0034587)3.35052386
71synaptonemal complex assembly (GO:0007130)3.30697132
72negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.25143437
73proteasome assembly (GO:0043248)3.23907637
74virion assembly (GO:0019068)3.20539911
75pyrimidine nucleoside salvage (GO:0043097)3.18756020
76pyrimidine-containing compound salvage (GO:0008655)3.18756020
77fertilization (GO:0009566)3.15313196
78neutrophil activation (GO:0042119)3.14318920
79ATP biosynthetic process (GO:0006754)3.13521810
80negative regulation of ligase activity (GO:0051352)3.11521917
81negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.11521917
82single strand break repair (GO:0000012)3.11267348
83gamete generation (GO:0007276)3.11188696
84regulation of mitochondrial translation (GO:0070129)3.08679638
85antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.08409090
86positive regulation of Cdc42 GTPase activity (GO:0043089)3.08364861
87protein refolding (GO:0042026)3.07291901
88granulocyte activation (GO:0036230)3.05300561
89DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.04975284
90transferrin transport (GO:0033572)3.04924162
91response to peptidoglycan (GO:0032494)3.03580806
92CTP biosynthetic process (GO:0006241)3.03237391
93CTP metabolic process (GO:0046036)3.03237391
94detection of bacterium (GO:0016045)3.01864907
95regulation of protein kinase A signaling (GO:0010738)3.01307711
96regulation of superoxide anion generation (GO:0032928)3.00251222
97modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.99886502
98positive regulation by organism of defense response of other organism involved in symbiotic interact2.99886502
99modulation by symbiont of host immune response (GO:0052553)2.99886502
100positive regulation by symbiont of host defense response (GO:0052509)2.99886502
101modulation by symbiont of host defense response (GO:0052031)2.99886502
102modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.99886502
103intraciliary transport (GO:0042073)2.99871975
104UTP metabolic process (GO:0046051)2.99425979
105proton transport (GO:0015992)2.98210085
106regulation of vacuole organization (GO:0044088)2.98073765
107microtubule severing (GO:0051013)2.97355767
108detection of other organism (GO:0098543)2.96600594
109signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.96284391
110intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.96284391
111ribonucleoside triphosphate biosynthetic process (GO:0009201)2.96069215
112protein maturation by protein folding (GO:0022417)2.95170784
113cell recognition (GO:0008037)2.92993141
114signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.92428015
115signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.92428015
116signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.92428015
117nucleoside triphosphate biosynthetic process (GO:0009142)2.92378587
118positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.91619905
119COPI coating of Golgi vesicle (GO:0048205)2.91551828
120Golgi transport vesicle coating (GO:0048200)2.91551828
121protein targeting to mitochondrion (GO:0006626)2.90692115
122establishment of protein localization to mitochondrion (GO:0072655)2.90560311
123antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.90480176
124positive regulation of gamma-delta T cell activation (GO:0046645)2.90161613
125hydrogen transport (GO:0006818)2.89364022
126left/right pattern formation (GO:0060972)2.88805110
127axoneme assembly (GO:0035082)2.85815373
128regulation of T-helper 2 cell differentiation (GO:0045628)2.85191084
129negative regulation of lymphocyte mediated immunity (GO:0002707)2.84300888
130ventricular system development (GO:0021591)2.83994494
131regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.83907906
132phagosome maturation (GO:0090382)2.78675567
133regulation of autophagic vacuole assembly (GO:2000785)2.78517130
134positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.75841782
135regulation of mast cell degranulation (GO:0043304)2.75247594
136amyloid precursor protein catabolic process (GO:0042987)2.74966035
137NIK/NF-kappaB signaling (GO:0038061)2.74076698
138Arp2/3 complex-mediated actin nucleation (GO:0034314)2.74050153
139immunoglobulin mediated immune response (GO:0016064)2.73224621
140negative regulation of glycoprotein biosynthetic process (GO:0010561)2.72969964
141sexual reproduction (GO:0019953)2.69862729
142regulation of T cell mediated cytotoxicity (GO:0001914)2.65705146
143negative regulation of interleukin-12 production (GO:0032695)2.61315068
144type I interferon signaling pathway (GO:0060337)2.58290027
145cellular response to type I interferon (GO:0071357)2.58290027
146pentose metabolic process (GO:0019321)2.57471578
147leukocyte aggregation (GO:0070486)2.57207218
148negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.56789380
149negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.56704391
150GDP-mannose metabolic process (GO:0019673)2.56181250
151cellular response to interleukin-15 (GO:0071350)2.55434767
152negative regulation of glycoprotein metabolic process (GO:1903019)2.54223678
153leukocyte degranulation (GO:0043299)2.53314889
154peptide catabolic process (GO:0043171)2.53177193
155interferon-gamma secretion (GO:0072643)2.52773277
156response to type I interferon (GO:0034340)2.48678769
157negative regulation of leukocyte mediated immunity (GO:0002704)2.48183251
158regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.47607308
159tolerance induction (GO:0002507)2.47019491
160positive regulation of T cell mediated cytotoxicity (GO:0001916)2.46912857
161neutrophil mediated immunity (GO:0002446)2.45881309
162negative regulation of T cell mediated immunity (GO:0002710)2.45620495
163regulation of dendritic cell antigen processing and presentation (GO:0002604)2.45523986
164response to interleukin-15 (GO:0070672)2.45482498
165chaperone mediated protein folding requiring cofactor (GO:0051085)2.44376836
166amino sugar catabolic process (GO:0046348)2.43904916
167membrane protein intracellular domain proteolysis (GO:0031293)2.43704738
168macrophage activation involved in immune response (GO:0002281)2.43583111
169NADH metabolic process (GO:0006734)2.41326811
170positive regulation of regulated secretory pathway (GO:1903307)2.40895169
171regulation of myeloid leukocyte mediated immunity (GO:0002886)2.39302005
172respiratory burst (GO:0045730)2.38700184
173pentose-phosphate shunt (GO:0006098)2.34269883
174regulation of defense response to virus by virus (GO:0050690)2.32518633
175negative regulation of innate immune response (GO:0045824)2.31900145
176regulation of mast cell activation involved in immune response (GO:0033006)2.31457707
177positive regulation of actin cytoskeleton reorganization (GO:2000251)2.30827467
178lipopolysaccharide-mediated signaling pathway (GO:0031663)2.30489238
179regulation of T cell tolerance induction (GO:0002664)2.30175928
180mitochondrial calcium ion transport (GO:0006851)2.29887260
181lipoxygenase pathway (GO:0019372)2.29426780
182myeloid cell activation involved in immune response (GO:0002275)2.29393951
183positive regulation of pseudopodium assembly (GO:0031274)2.28700394
184positive regulation of triglyceride lipase activity (GO:0061365)2.28615973
185positive regulation of lipoprotein lipase activity (GO:0051006)2.28615973
186regulation of leukocyte degranulation (GO:0043300)2.28272064
187nucleotide salvage (GO:0043173)2.27962320
188regulation of regulated secretory pathway (GO:1903305)2.27809886
189deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.27523824
190positive regulation of mast cell degranulation (GO:0043306)2.26233112
191positive regulation of mast cell activation involved in immune response (GO:0033008)2.26233112
192nucleoside salvage (GO:0043174)2.25244449
193response to acidic pH (GO:0010447)2.23960348
194actin nucleation (GO:0045010)2.23832783

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse5.33037145
2NOTCH1_17114293_ChIP-ChIP_T-ALL_Human4.33235173
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.25467566
4CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human4.08106057
5EZH2_22144423_ChIP-Seq_EOC_Human3.64560555
6* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.95276204
7* GABP_17652178_ChIP-ChIP_JURKAT_Human2.92331474
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.83156022
9BP1_19119308_ChIP-ChIP_Hs578T_Human2.81869822
10EST1_17652178_ChIP-ChIP_JURKAT_Human2.68869892
11* ETS1_20019798_ChIP-Seq_JURKAT_Human2.38235956
12SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.29868658
13HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.25475427
14THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.20625037
15IRF8_22096565_ChIP-ChIP_GC-B_Human2.20312471
16VDR_22108803_ChIP-Seq_LS180_Human2.13342471
17LXR_22292898_ChIP-Seq_THP-1_Human2.06424061
18* CREB1_15753290_ChIP-ChIP_HEK293T_Human2.00622109
19IRF8_21731497_ChIP-ChIP_J774_Mouse1.97211719
20NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.95259996
21HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.86697735
22MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.85111529
23PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.82144397
24ELF1_20517297_ChIP-Seq_JURKAT_Human1.79725491
25BCL6_27268052_Chip-Seq_Bcells_Human1.78770289
26TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.76452087
27* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.75151278
28FLI1_27457419_Chip-Seq_LIVER_Mouse1.73710375
29VDR_21846776_ChIP-Seq_THP-1_Human1.70823325
30CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.70650661
31* SRF_21415370_ChIP-Seq_HL-1_Mouse1.67341412
32SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.66035036
33BCOR_27268052_Chip-Seq_Bcells_Human1.65256439
34ELK3_25401928_ChIP-Seq_HUVEC_Human1.64749661
35STAT4_19710469_ChIP-ChIP_TH1__Mouse1.62485718
36SRY_22984422_ChIP-ChIP_TESTIS_Rat1.62324326
37YY1_21170310_ChIP-Seq_MESCs_Mouse1.61760961
38THAP11_20581084_ChIP-Seq_MESCs_Mouse1.61473111
39TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.59733299
40P68_20966046_ChIP-Seq_HELA_Human1.58379071
41RARG_19884340_ChIP-ChIP_MEFs_Mouse1.56064512
42NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.53670958
43SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.53572944
44* VDR_23849224_ChIP-Seq_CD4+_Human1.53282415
45UTX_26944678_Chip-Seq_JUKART_Human1.52317174
46CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.52225858
47MYC_18358816_ChIP-ChIP_MESCs_Mouse1.51424947
48PCGF2_27294783_Chip-Seq_ESCs_Mouse1.51412191
49* SPI1_23547873_ChIP-Seq_NB4_Human1.51385326
50FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.49075211
51MAF_26560356_Chip-Seq_TH1_Human1.45312238
52NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.44350409
53* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.43943408
54PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.42665533
55EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.40583237
56REST_21632747_ChIP-Seq_MESCs_Mouse1.39852748
57ELF1_17652178_ChIP-ChIP_JURKAT_Human1.39723147
58MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.39017917
59MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.37760054
60ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.36487342
61GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.35367856
62MAF_26560356_Chip-Seq_TH2_Human1.35222662
63E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.34823529
64LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.34749927
65VDR_24763502_ChIP-Seq_THP-1_Human1.34273661
66RUNX1_22412390_ChIP-Seq_EML_Mouse1.34211601
67CTCF_18555785_ChIP-Seq_MESCs_Mouse1.33849156
68TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.33847924
69SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.33710058
70TAF15_26573619_Chip-Seq_HEK293_Human1.33348184
71SPI1_23127762_ChIP-Seq_K562_Human1.32723788
72PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.32177832
73CTCF_27219007_Chip-Seq_ERYTHROID_Human1.31686854
74RACK7_27058665_Chip-Seq_MCF-7_Human1.31214610
75SA1_27219007_Chip-Seq_Bcells_Human1.30975019
76SA1_27219007_Chip-Seq_ERYTHROID_Human1.28981449
77ZNF274_21170338_ChIP-Seq_K562_Hela1.28868710
78CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.27506199
79GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.27242265
80* DCP1A_22483619_ChIP-Seq_HELA_Human1.27202436
81ZFP57_27257070_Chip-Seq_ESCs_Mouse1.26227690
82E2F1_20622854_ChIP-Seq_HELA_Human1.25562576
83RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.25335096
84CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.23814704
85PU.1_20513432_ChIP-Seq_Bcells_Mouse1.23134550
86GATA3_21867929_ChIP-Seq_CD8_Mouse1.22276956
87CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.22265734
88IKZF1_21737484_ChIP-ChIP_HCT116_Human1.22085594
89YY1_22570637_ChIP-Seq_MALME-3M_Human1.21009719
90ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.20718057
91PHF8_20622854_ChIP-Seq_HELA_Human1.20558962
92CBX2_27304074_Chip-Seq_ESCs_Mouse1.18508827
93* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.18016276
94GATA1_22383799_ChIP-Seq_G1ME_Mouse1.17175251
95* CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.16522420
96* GABP_19822575_ChIP-Seq_HepG2_Human1.15563467
97SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.15353869
98* FOXP3_21729870_ChIP-Seq_TREG_Human1.15050528
99CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.14935224
100PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.13883077
101SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.13698753
102IRF8_27001747_Chip-Seq_BMDM_Mouse1.13616221
103SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.12474702
104* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.12222147
105KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.11848920
106TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.11196358
107RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.11168695
108P300_27268052_Chip-Seq_Bcells_Human1.09997774
109GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.09670895
110EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.09535388
111EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.09430031
112STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.09056681
113SMC4_20622854_ChIP-Seq_HELA_Human1.08616074
114* CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.07920536
115REST_18959480_ChIP-ChIP_MESCs_Mouse1.07625151
116CTBP2_25329375_ChIP-Seq_LNCAP_Human1.07547530
117SOX2_22085726_ChIP-Seq_NPCs_Mouse1.07397422
118MYB_21317192_ChIP-Seq_ERMYB_Mouse1.06616377
119SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.06601778
120CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.06600611
121TTF2_22483619_ChIP-Seq_HELA_Human1.05759354
122TET1_21451524_ChIP-Seq_MESCs_Mouse1.04783659
123RBPJ_22232070_ChIP-Seq_NCS_Mouse1.03463853
124* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.03225593
125BRD4_27068464_Chip-Seq_AML-cells_Mouse1.02770215
126IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.02211060
127GATA3_21867929_ChIP-Seq_TH1_Mouse1.02155719
128LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.02019109
129NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.01716948
130RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.01634937
131ETS1_21867929_ChIP-Seq_TH2_Mouse1.01130805
132FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.00326308
133DNAJC2_21179169_ChIP-ChIP_NT2_Human1.00171781
134PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.00091557
135* SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.99475484
136* IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.98311746
137RAD21_21589869_ChIP-Seq_MESCs_Mouse0.96672563
138MYC_18555785_ChIP-Seq_MESCs_Mouse0.95730806
139MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.95289205
140PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.93829102
141KAP1_22055183_ChIP-Seq_ESCs_Mouse0.93798889
142XRN2_22483619_ChIP-Seq_HELA_Human0.93718442
143CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.92503131
144HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.90629301
145BMI1_23680149_ChIP-Seq_NPCS_Mouse0.90605380
146SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.89301932
147KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.88718630
148RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.87883775
149ETV2_25802403_ChIP-Seq_MESCs_Mouse0.87752240
150BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.85822452
151MYC_19030024_ChIP-ChIP_MESCs_Mouse0.85204320
152TAL1_26923725_Chip-Seq_HPCs_Mouse0.84564830
153ERG_20517297_ChIP-Seq_VCAP_Human0.83708265
154RNF2_27304074_Chip-Seq_NSC_Mouse0.83702905
155KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.83599884
156STAT1_20625510_ChIP-Seq_HELA_Human0.82449891
157ELK1_22589737_ChIP-Seq_MCF10A_Human0.82051383
158CTCF_26484167_Chip-Seq_Bcells_Mouse0.81790682
159TP53_22573176_ChIP-Seq_HFKS_Human0.81320433
160FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.81044921
161STAT1_17558387_ChIP-Seq_HELA_Human0.80568838
162CTCF_20526341_ChIP-Seq_ESCs_Human0.79825683
163PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.78467887
164* ELK1_19687146_ChIP-ChIP_HELA_Human0.78308434
165CBP_20019798_ChIP-Seq_JUKART_Human0.77814565
166IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.77814565
167NFE2_27457419_Chip-Seq_LIVER_Mouse0.77641104

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization8.50977503
2MP0003880_abnormal_central_pattern3.70037476
3MP0003436_decreased_susceptibility_to3.58997006
4MP0003698_abnormal_male_reproductive3.05033848
5MP0008877_abnormal_DNA_methylation2.93630410
6MP0002736_abnormal_nociception_after2.89349064
7MP0003191_abnormal_cellular_cholesterol2.77251793
8MP0001968_abnormal_touch/_nociception2.76277952
9MP0005058_abnormal_lysosome_morphology2.69604902
10MP0003303_peritoneal_inflammation2.69167370
11MP0001929_abnormal_gametogenesis2.66449936
12MP0001529_abnormal_vocalization2.53960265
13MP0009046_muscle_twitch2.45691453
14MP0003646_muscle_fatigue2.45254796
15MP0009840_abnormal_foam_cell2.44648565
16MP0006276_abnormal_autonomic_nervous2.34361241
17MP0003806_abnormal_nucleotide_metabolis2.32572326
18MP0002419_abnormal_innate_immunity2.19112601
19MP0001986_abnormal_taste_sensitivity2.16221062
20MP0003329_amyloid_beta_deposits2.15393353
21MP0005464_abnormal_platelet_physiology2.12870770
22MP0001905_abnormal_dopamine_level2.12639794
23MP0002822_catalepsy2.01165687
24MP0002638_abnormal_pupillary_reflex1.99017772
25MP0001790_abnormal_immune_system1.93518727
26MP0005387_immune_system_phenotype1.93518727
27MP0001533_abnormal_skeleton_physiology1.91679933
28MP0005451_abnormal_body_composition1.90163385
29MP0002735_abnormal_chemical_nociception1.87930814
30MP0000604_amyloidosis1.87329867
31MP0010155_abnormal_intestine_physiology1.86815869
32MP0002163_abnormal_gland_morphology1.85970444
33MP0002837_dystrophic_cardiac_calcinosis1.82724626
34MP0002064_seizures1.81774540
35MP0001800_abnormal_humoral_immune1.81294142
36MP0001984_abnormal_olfaction1.75811451
37MP0009745_abnormal_behavioral_response1.73929492
38MP0002734_abnormal_mechanical_nocicepti1.73797535
39MP0000685_abnormal_immune_system1.73005486
40MP0002452_abnormal_antigen_presenting1.72945824
41MP0002420_abnormal_adaptive_immunity1.70111228
42MP0001819_abnormal_immune_cell1.69464893
43MP0003635_abnormal_synaptic_transmissio1.66231096
44MP0003172_abnormal_lysosome_physiology1.65921199
45MP0003075_altered_response_to1.65784405
46MP0001845_abnormal_inflammatory_respons1.62557016
47MP0003300_gastrointestinal_ulcer1.62474789
48MP0002272_abnormal_nervous_system1.61534542
49MP0002653_abnormal_ependyma_morphology1.61049468
50MP0003183_abnormal_peptide_metabolism1.60965343
51MP0000678_abnormal_parathyroid_gland1.60175223
52MP0001440_abnormal_grooming_behavior1.59819830
53MP0002210_abnormal_sex_determination1.57030615
54MP0002160_abnormal_reproductive_system1.54727058
55MP0004859_abnormal_synaptic_plasticity1.52218932
56MP0002161_abnormal_fertility/fecundity1.51420959
57MP0009379_abnormal_foot_pigmentation1.50337992
58MP0002572_abnormal_emotion/affect_behav1.49708086
59MP0004142_abnormal_muscle_tone1.49129211
60MP0009764_decreased_sensitivity_to1.47345461
61MP0005365_abnormal_bile_salt1.46532371
62MP0006036_abnormal_mitochondrial_physio1.44847947
63MP0000343_altered_response_to1.44629804
64MP0008469_abnormal_protein_level1.42964706
65MP0001970_abnormal_pain_threshold1.41269134
66MP0005166_decreased_susceptibility_to1.39856526
67MP0004270_analgesia1.39319802
68MP0001188_hyperpigmentation1.38646767
69MP0009785_altered_susceptibility_to1.38259289
70MP0004947_skin_inflammation1.34857609
71MP0002405_respiratory_system_inflammati1.34435002
72MP0003186_abnormal_redox_activity1.34157577
73MP0006035_abnormal_mitochondrial_morpho1.32174661
74MP0002876_abnormal_thyroid_physiology1.30478431
75MP0002067_abnormal_sensory_capabilities1.29650794
76MP0002063_abnormal_learning/memory/cond1.28715609
77MP0002733_abnormal_thermal_nociception1.27605069
78MP0002148_abnormal_hypersensitivity_rea1.26785471
79MP0000716_abnormal_immune_system1.25797514
80MP0001145_abnormal_male_reproductive1.25497546
81MP0001501_abnormal_sleep_pattern1.23307384
82MP0005671_abnormal_response_to1.22670520
83MP0000465_gastrointestinal_hemorrhage1.22010229
84MP0005360_urolithiasis1.21792054
85MP0010386_abnormal_urinary_bladder1.19785069
86MP0000372_irregular_coat_pigmentation1.19146134
87MP0002139_abnormal_hepatobiliary_system1.16785434
88MP0002398_abnormal_bone_marrow1.14696829
89MP0002277_abnormal_respiratory_mucosa1.12785431
90MP0005423_abnormal_somatic_nervous1.12203786
91MP0000858_altered_metastatic_potential1.12016127
92MP0003724_increased_susceptibility_to1.11720178
93MP0003763_abnormal_thymus_physiology1.09050747
94MP0004019_abnormal_vitamin_homeostasis1.08068361
95MP0002429_abnormal_blood_cell1.05096711
96MP0003122_maternal_imprinting1.04255176
97MP0001873_stomach_inflammation1.02844858
98MP0005646_abnormal_pituitary_gland1.02391044
99MP0000653_abnormal_sex_gland1.02326787
100MP0002751_abnormal_autonomic_nervous1.00304418
101MP0005377_hearing/vestibular/ear_phenot1.00286280
102MP0003878_abnormal_ear_physiology1.00286280
103MP0008004_abnormal_stomach_pH0.97608591
104MP0005083_abnormal_biliary_tract0.97588938
105MP0004924_abnormal_behavior0.97473388
106MP0005386_behavior/neurological_phenoty0.97473388
107MP0005379_endocrine/exocrine_gland_phen0.97436944
108MP0005310_abnormal_salivary_gland0.96498056
109MP0008874_decreased_physiological_sensi0.96023286
110MP0002722_abnormal_immune_system0.95575975
111MP0001765_abnormal_ion_homeostasis0.95468431
112MP0005535_abnormal_body_temperature0.93309160
113MP0005085_abnormal_gallbladder_physiolo0.93193570
114MP0000689_abnormal_spleen_morphology0.92653300
115MP0001835_abnormal_antigen_presentation0.92130325
116MP0000015_abnormal_ear_pigmentation0.91916870
117MP0005319_abnormal_enzyme/_coenzyme0.91325723
118MP0000749_muscle_degeneration0.91161173
119MP0005584_abnormal_enzyme/coenzyme_acti0.90672572
120MP0005408_hypopigmentation0.89857111
121MP0008569_lethality_at_weaning0.89653534
122MP0006082_CNS_inflammation0.88983952
123MP0008875_abnormal_xenobiotic_pharmacok0.87837538
124MP0000013_abnormal_adipose_tissue0.86711394
125MP0003638_abnormal_response/metabolism_0.86318919
126MP0005165_increased_susceptibility_to0.85736867
127MP0009643_abnormal_urine_homeostasis0.84554490
128MP0000681_abnormal_thyroid_gland0.84229711
129MP0000358_abnormal_cell_content/0.84071275
130MP0004811_abnormal_neuron_physiology0.82627509
131MP0003787_abnormal_imprinting0.81820797
132MP0004036_abnormal_muscle_relaxation0.81806818
133MP0000751_myopathy0.81503183
134MP0001663_abnormal_digestive_system0.81361402
135MP0003656_abnormal_erythrocyte_physiolo0.81037168
136MP0005389_reproductive_system_phenotype0.80672090
137MP0000609_abnormal_liver_physiology0.80560434
138MP0002184_abnormal_innervation0.79590638
139MP0002796_impaired_skin_barrier0.78744610
140MP0002557_abnormal_social/conspecific_i0.78704279
141MP0005167_abnormal_blood-brain_barrier0.78223474
142MP0002998_abnormal_bone_remodeling0.78081872
143MP0003828_pulmonary_edema0.78068413
144MP0004510_myositis0.77576742
145MP0001764_abnormal_homeostasis0.76893201
146MP0003879_abnormal_hair_cell0.75842476
147MP0009763_increased_sensitivity_to0.75166808
148MP0001727_abnormal_embryo_implantation0.75087781
149MP0005000_abnormal_immune_tolerance0.74129441
150MP0000490_abnormal_crypts_of0.74080049
151MP0003011_delayed_dark_adaptation0.74057394
152MP0008932_abnormal_embryonic_tissue0.73167196
153MP0000703_abnormal_thymus_morphology0.73033353
154MP0002066_abnormal_motor_capabilities/c0.69843485
155MP0009697_abnormal_copulation0.69722337
156MP0005623_abnormal_meninges_morphology0.68084580
157MP0001664_abnormal_digestion0.67606532
158MP0001348_abnormal_lacrimal_gland0.67081150
159MP0001486_abnormal_startle_reflex0.66586942
160MP0004233_abnormal_muscle_weight0.66198645
161MP0001542_abnormal_bone_strength0.63957660
162MP0008260_abnormal_autophagy0.63567078
163MP0005084_abnormal_gallbladder_morpholo0.62829300
164MP0009333_abnormal_splenocyte_physiolog0.61920993
165MP0008872_abnormal_physiological_respon0.61270472
166MP0002882_abnormal_neuron_morphology0.60760498
167MP0003866_abnormal_defecation0.60456352
168MP0002132_abnormal_respiratory_system0.60241058
169MP0003786_premature_aging0.60204646
170MP0004084_abnormal_cardiac_muscle0.60097865
171MP0005025_abnormal_response_to0.59883974
172MP0002909_abnormal_adrenal_gland0.59372018
173MP0002723_abnormal_immune_serum0.58589041
174MP0005636_abnormal_mineral_homeostasis0.56958971

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)7.62575568
2Dynein arm defect of respiratory motile cilia (HP:0012255)7.46628608
3Absent/shortened dynein arms (HP:0200106)7.46628608
4Abnormal respiratory epithelium morphology (HP:0012253)6.01098467
5Abnormal respiratory motile cilium morphology (HP:0005938)6.01098467
6Abnormal respiratory motile cilium physiology (HP:0012261)5.97184883
7Rhinitis (HP:0012384)5.24792056
8Abnormal ciliary motility (HP:0012262)5.19592476
9Acute necrotizing encephalopathy (HP:0006965)5.08829846
10Abnormal mitochondria in muscle tissue (HP:0008316)4.69074158
11Mitochondrial inheritance (HP:0001427)4.59578620
12Chronic bronchitis (HP:0004469)4.32041331
13Progressive macrocephaly (HP:0004481)4.20856904
14Stomatitis (HP:0010280)4.13401649
15Abnormality of macrophages (HP:0004311)3.92262870
16Myositis (HP:0100614)3.85839850
17Increased CSF lactate (HP:0002490)3.84080270
18Infertility (HP:0000789)3.82022408
19Hepatocellular necrosis (HP:0001404)3.80146693
20Eczematoid dermatitis (HP:0000976)3.75839385
21Acute encephalopathy (HP:0006846)3.68212396
22Elevated erythrocyte sedimentation rate (HP:0003565)3.64644601
23Recurrent bacterial skin infections (HP:0005406)3.62226268
24Recurrent abscess formation (HP:0002722)3.61902523
25Nasal polyposis (HP:0100582)3.58429249
26Medial flaring of the eyebrow (HP:0010747)3.55396903
27Abnormality of liposaccharide metabolism (HP:0010968)3.42516334
28Abnormality of glycosphingolipid metabolism (HP:0004343)3.42516334
29Abnormality of glycolipid metabolism (HP:0010969)3.42516334
30Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.37566819
31Decreased activity of mitochondrial respiratory chain (HP:0008972)3.37566819
32Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.34243593
33Increased hepatocellular lipid droplets (HP:0006565)3.24994792
34Optic disc pallor (HP:0000543)3.10518205
35Hepatic necrosis (HP:0002605)3.08459235
36Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.05381776
37Petechiae (HP:0000967)3.01451448
38Exercise intolerance (HP:0003546)2.95256408
39Loss of speech (HP:0002371)2.91996388
40Nephronophthisis (HP:0000090)2.88556405
41Gait imbalance (HP:0002141)2.88316419
42Congenital primary aphakia (HP:0007707)2.87601537
43Abnormality of the nasal mucosa (HP:0000433)2.87217202
44Chronic obstructive pulmonary disease (HP:0006510)2.85325831
45Obstructive lung disease (HP:0006536)2.85325831
46Lipid accumulation in hepatocytes (HP:0006561)2.82967111
47Purpura (HP:0000979)2.78983979
48Vacuolated lymphocytes (HP:0001922)2.78423587
49Bronchitis (HP:0012387)2.77636654
50Respiratory failure (HP:0002878)2.71058465
51Bronchiectasis (HP:0002110)2.64050557
52Lactic acidosis (HP:0003128)2.62629759
53Renal Fanconi syndrome (HP:0001994)2.62163033
54Systemic lupus erythematosus (HP:0002725)2.59411070
55Increased serum lactate (HP:0002151)2.58674266
56Nephrogenic diabetes insipidus (HP:0009806)2.58254454
57Neuroendocrine neoplasm (HP:0100634)2.58113424
58Molar tooth sign on MRI (HP:0002419)2.49834660
59Abnormality of midbrain morphology (HP:0002418)2.49834660
60Mediastinal lymphadenopathy (HP:0100721)2.48574474
61Increased intramyocellular lipid droplets (HP:0012240)2.48379949
62Poor suck (HP:0002033)2.47595277
63Pustule (HP:0200039)2.47590071
64Gastrointestinal infarctions (HP:0005244)2.47116753
65Progressive neurologic deterioration (HP:0002344)2.46965254
66Exertional dyspnea (HP:0002875)2.45774334
67Increased IgM level (HP:0003496)2.42473578
683-Methylglutaconic aciduria (HP:0003535)2.41564149
69Abnormality of renal resorption (HP:0011038)2.40325875
70Episodic fever (HP:0001954)2.39145005
71Urticaria (HP:0001025)2.36021226
72Leukodystrophy (HP:0002415)2.35730380
73Myokymia (HP:0002411)2.32381217
74Pheochromocytoma (HP:0002666)2.31402540
75Recurrent gram-negative bacterial infections (HP:0005420)2.28349291
76Supranuclear gaze palsy (HP:0000605)2.28253448
77Hypothermia (HP:0002045)2.26891172
78Cholecystitis (HP:0001082)2.26777159
79Abnormal gallbladder physiology (HP:0012438)2.26777159
80Focal motor seizures (HP:0011153)2.25916054
81Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.25488137
82Recurrent sinusitis (HP:0011108)2.25203302
83Interstitial pulmonary disease (HP:0006530)2.24887012
84Cerebral edema (HP:0002181)2.24549263
85Axonal loss (HP:0003447)2.24245606
86Growth hormone excess (HP:0000845)2.23310778
87Recurrent skin infections (HP:0001581)2.22830599
88Prolonged neonatal jaundice (HP:0006579)2.19558299
89Upper limb muscle weakness (HP:0003484)2.18662483
90Emotional lability (HP:0000712)2.15898428
91Increased cerebral lipofuscin (HP:0011813)2.15779691
92Spastic paraparesis (HP:0002313)2.14845936
93Hypertensive crisis (HP:0100735)2.13210109
94Pancreatic fibrosis (HP:0100732)2.12636955
95Gingivitis (HP:0000230)2.10552468
96Vertebral compression fractures (HP:0002953)2.08778493
97Increased muscle lipid content (HP:0009058)2.07948349
98Generalized aminoaciduria (HP:0002909)2.07918622
99Mutism (HP:0002300)2.07277349
100Increased IgE level (HP:0003212)2.05887190
101Delusions (HP:0000746)2.05347455
102Vaginal atresia (HP:0000148)2.05192843
103Abnormality of glycolysis (HP:0004366)2.04915874
104Increased serum pyruvate (HP:0003542)2.04915874
105Amyloidosis (HP:0011034)2.04323783
106True hermaphroditism (HP:0010459)2.04203980
107Dysostosis multiplex (HP:0000943)2.04144381
108Increased serum ferritin (HP:0003281)2.04063370
109Hepatosplenomegaly (HP:0001433)2.03395163
110Hand muscle atrophy (HP:0009130)2.03347076
111Encephalitis (HP:0002383)2.02853632
112Genital tract atresia (HP:0001827)2.02226960
113Abnormal hair whorl (HP:0010721)2.01199549
114Pulmonary infiltrates (HP:0002113)2.01026798
115Abnormality of cells of the erythroid lineage (HP:0012130)1.97420519
116Hypergammaglobulinemia (HP:0010702)1.96018268
117Cerebral hypomyelination (HP:0006808)1.95276457
118Anorexia (HP:0002039)1.94877045
119Atonic seizures (HP:0010819)1.94712321
120Hypokinesia (HP:0002375)1.94708153
121Poor coordination (HP:0002370)1.93098457
122Prolonged bleeding time (HP:0003010)1.92215126
123Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.90253911
124Aplasia/Hypoplasia of the lens (HP:0008063)1.89792048
125Abnormal number of erythroid precursors (HP:0012131)1.89666890
126Tetany (HP:0001281)1.89241095
127Gastrointestinal inflammation (HP:0004386)1.89081319
128Abnormal hemoglobin (HP:0011902)1.88607098
129Vasculitis (HP:0002633)1.88436905
130Rough bone trabeculation (HP:0100670)1.87909187
131Abnormality of T cell physiology (HP:0011840)1.87901921
132Increased neuronal autofluorescent lipopigment (HP:0002074)1.87801056
133Retrobulbar optic neuritis (HP:0100654)1.87202391
134Optic neuritis (HP:0100653)1.87202391
135Gingival bleeding (HP:0000225)1.86709576
136Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.86673417
137Decreased muscle mass (HP:0003199)1.85092903
138Type 2 muscle fiber atrophy (HP:0003554)1.84651319
139Respiratory difficulties (HP:0002880)1.84225359
140Meningitis (HP:0001287)1.83775856
141Polyphagia (HP:0002591)1.83115718
142Inflammation of the large intestine (HP:0002037)1.82862492
143Abnormality of polysaccharide metabolism (HP:0011012)1.82676328
144Abnormality of glycosaminoglycan metabolism (HP:0004371)1.82676328
145Abnormality of mucopolysaccharide metabolism (HP:0011020)1.82676328
146Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.82414164
147Distal upper limb amyotrophy (HP:0007149)1.81664672
148Upper limb amyotrophy (HP:0009129)1.81664672
149Epistaxis (HP:0000421)1.80989329
150Recurrent otitis media (HP:0000403)1.80854193
151Abnormality of the renal medulla (HP:0100957)1.80702587
152Abnormality of iron homeostasis (HP:0011031)1.79706760
153Gangrene (HP:0100758)1.79490978
154Muscle fiber atrophy (HP:0100295)1.78618425
155Limb dystonia (HP:0002451)1.77214192
156Joint swelling (HP:0001386)1.76173371
157Abnormal platelet function (HP:0011869)1.76117571
158Impaired platelet aggregation (HP:0003540)1.76117571
159Hypoplasia of the capital femoral epiphysis (HP:0003090)1.75849242
160Severe visual impairment (HP:0001141)1.75489881
161Keratoconjunctivitis sicca (HP:0001097)1.75413977
162Pancreatic cysts (HP:0001737)1.75270056
163Recurrent bronchitis (HP:0002837)1.74700202
164Abnormality of the costochondral junction (HP:0000919)1.74454726
165Glomerulopathy (HP:0100820)1.72704271
166Recurrent fungal infections (HP:0002841)1.72684153
167Abnormality of glutamine family amino acid metabolism (HP:0010902)1.72010317
168Abnormal spermatogenesis (HP:0008669)1.69296086
169Abnormality of the heme biosynthetic pathway (HP:0010472)1.68818077
170Chest pain (HP:0100749)1.68251531
171Abnormality of transition element cation homeostasis (HP:0011030)1.67074199
172Chronic sinusitis (HP:0011109)1.66510172
173Epileptic encephalopathy (HP:0200134)1.64666150
174Delayed gross motor development (HP:0002194)1.63721581
175Progressive inability to walk (HP:0002505)1.63690526
176Retinal dysplasia (HP:0007973)1.62641617
177Progressive external ophthalmoplegia (HP:0000590)1.62060887
178Unsteady gait (HP:0002317)1.61883131
179Oculomotor apraxia (HP:0000657)1.61691837
180CNS demyelination (HP:0007305)1.57448131
181Aplasia/Hypoplasia of the sacrum (HP:0008517)1.54132453
182Orchitis (HP:0100796)1.54067399
183Tongue fasciculations (HP:0001308)1.48290559
184Microvesicular hepatic steatosis (HP:0001414)1.47553686

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK35.10256881
2PDK45.10256881
3TESK14.41816904
4ERN13.47235091
5MAP3K123.41629523
6PDK23.27516426
7CASK3.26364363
8TLK13.24644527
9ARAF2.44888564
10NME12.30687077
11PIM22.05522143
12TESK22.01634041
13BCKDK1.96652525
14BUB11.89085033
15GRK61.80314784
16CDK191.77321566
17MYLK1.75983318
18TYK21.68986162
19EPHB11.63162725
20STK161.60297007
21EIF2AK11.57091528
22MAP2K71.54516242
23MAP3K31.51747429
24BRAF1.48527697
25KSR21.47806529
26VRK21.41823002
27TAOK21.40110285
28LIMK11.38595074
29PTK2B1.36802195
30EPHA21.32833745
31NME21.32394923
32GRK71.32098609
33MST41.26890392
34PRPF4B1.26639222
35MAP3K11.23864469
36WNK41.23227853
37BMPR1B1.22523772
38TSSK61.21168178
39LMTK21.17170809
40PNCK1.16935538
41TAOK11.16724760
42BLK1.15810153
43CSK1.15790586
44PLK21.15726375
45MAP2K31.14554443
46PRKD31.12522319
47SRPK11.11677824
48CCNB11.11253981
49NTRK31.09312928
50GRK51.09132837
51IRAK11.08276992
52DAPK31.07777710
53STK391.07099843
54LRRK21.04505626
55RIPK41.02104736
56MATK1.01451090
57DAPK11.01021628
58TXK0.98536698
59TRIM280.95454806
60SIK30.94490515
61TNK20.93941983
62MAP3K110.93154799
63MINK10.90808301
64VRK10.90439619
65MUSK0.89864242
66IKBKE0.89208085
67ABL20.86978212
68RAF10.85791509
69JAK30.82738425
70PRKCG0.77331273
71CSF1R0.77006976
72CDK80.75737555
73PBK0.73630614
74DAPK20.73318564
75EIF2AK30.72899497
76MST1R0.71883701
77IKBKB0.70535785
78ADRBK20.69005138
79HCK0.67583945
80JAK20.67553546
81BTK0.67386669
82MAP3K20.67091608
83DYRK1B0.65344340
84FGR0.65305367
85PLK40.64749533
86MAP3K40.63522535
87STK380.62068786
88ZAP700.61609399
89MAPKAPK50.60313156
90PTK60.60132907
91ILK0.60090412
92CDK140.59797090
93SMG10.59755566
94TBK10.59726302
95MAP3K50.59151216
96NEK90.59090053
97LYN0.58831554
98BMPR20.58433881
99KSR10.58204764
100CDK180.57100131
101CAMKK20.56268154
102MARK20.55520752
103MOS0.55456532
104MAPKAPK20.55093893
105MAP4K20.55061664
106CAMK2B0.54908072
107AKT30.54873841
108ADRBK10.54242274
109MAPK130.53860446
110BMX0.53785503
111PAK40.53241223
112DDR20.52628257
113DYRK30.51946459
114CAMK2A0.51873641
115MAP2K60.51770284
116JAK10.50677578
117IRAK20.50674608
118CDK11A0.50293550
119ICK0.50237285
120LCK0.49853759
121CDK150.49758594
122BCR0.49284558
123AURKA0.49169666
124IRAK40.48485704
125IRAK30.48315110
126KDR0.48117225
127CAMK2G0.47502836
128SIK20.46780990
129PAK10.46224805
130PDK10.46004857
131MAPKAPK30.45733424
132PINK10.44727281
133FYN0.43986319
134MAP2K20.42690847
135MKNK20.41728257
136STK100.41035331
137CAMK2D0.40632625
138SYK0.40245776
139PRKD20.40090766
140EPHA30.39600703
141TAOK30.38934466
142MAP4K10.38613844
143CSNK2A10.38330091
144MAP3K140.37683843
145STK38L0.37446606
146YES10.36971682
147FES0.35464919
148TNIK0.33902165
149UHMK10.31728612
150PRKCD0.31369498
151MAP3K90.28390389
152PRKG20.27737578
153PDPK10.26791120
154DYRK20.25965089
155PRKCE0.25934531
156OXSR10.24667506
157GRK10.23564238
158PLK30.21364187
159PRKACA0.20696640

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001905.06279323
2Proteasome_Homo sapiens_hsa030504.32277504
3Parkinsons disease_Homo sapiens_hsa050124.28947070
4Huntingtons disease_Homo sapiens_hsa050163.47199593
5Collecting duct acid secretion_Homo sapiens_hsa049663.19672973
6Alzheimers disease_Homo sapiens_hsa050103.11404358
7Ribosome_Homo sapiens_hsa030102.89560381
8Synaptic vesicle cycle_Homo sapiens_hsa047212.57478250
9Protein export_Homo sapiens_hsa030602.47162680
10Cardiac muscle contraction_Homo sapiens_hsa042602.38562891
11Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.38025147
12Vibrio cholerae infection_Homo sapiens_hsa051102.22201874
13RNA polymerase_Homo sapiens_hsa030202.05617232
14Osteoclast differentiation_Homo sapiens_hsa043801.99283518
15Leishmaniasis_Homo sapiens_hsa051401.97246718
16Sulfur metabolism_Homo sapiens_hsa009201.79164305
17Staphylococcus aureus infection_Homo sapiens_hsa051501.71668646
18Rheumatoid arthritis_Homo sapiens_hsa053231.66720661
19Lysosome_Homo sapiens_hsa041421.60299348
20Basal transcription factors_Homo sapiens_hsa030221.59973649
21Tuberculosis_Homo sapiens_hsa051521.59844387
22Cyanoamino acid metabolism_Homo sapiens_hsa004601.49652781
23Glycosaminoglycan degradation_Homo sapiens_hsa005311.49287390
24Nicotine addiction_Homo sapiens_hsa050331.47603553
25Pyruvate metabolism_Homo sapiens_hsa006201.46396342
26Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.46291452
27Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.46235618
28Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.42999189
29Pyrimidine metabolism_Homo sapiens_hsa002401.42717467
30Endocytosis_Homo sapiens_hsa041441.41477153
31Toll-like receptor signaling pathway_Homo sapiens_hsa046201.35432214
32Type I diabetes mellitus_Homo sapiens_hsa049401.32985809
33Amphetamine addiction_Homo sapiens_hsa050311.27973505
34Graft-versus-host disease_Homo sapiens_hsa053321.23096246
35Viral myocarditis_Homo sapiens_hsa054161.22849314
36Pertussis_Homo sapiens_hsa051331.16156842
37Purine metabolism_Homo sapiens_hsa002301.15123120
38SNARE interactions in vesicular transport_Homo sapiens_hsa041301.14912689
39Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.10026115
40Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.08481601
41NOD-like receptor signaling pathway_Homo sapiens_hsa046211.07704607
42Chemokine signaling pathway_Homo sapiens_hsa040621.07348729
43Influenza A_Homo sapiens_hsa051641.06539332
44B cell receptor signaling pathway_Homo sapiens_hsa046621.05702731
45Drug metabolism - other enzymes_Homo sapiens_hsa009831.04174073
46Hematopoietic cell lineage_Homo sapiens_hsa046401.02823662
47Fructose and mannose metabolism_Homo sapiens_hsa000511.01426786
48Malaria_Homo sapiens_hsa051440.99606712
49Olfactory transduction_Homo sapiens_hsa047400.99296533
50Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.98652834
51Allograft rejection_Homo sapiens_hsa053300.98353890
52Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.98259965
53Phagosome_Homo sapiens_hsa041450.95812903
54NF-kappa B signaling pathway_Homo sapiens_hsa040640.95640009
55Acute myeloid leukemia_Homo sapiens_hsa052210.92999454
56RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.92408987
57TNF signaling pathway_Homo sapiens_hsa046680.91405599
58Spliceosome_Homo sapiens_hsa030400.91375585
59Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.90410513
60Herpes simplex infection_Homo sapiens_hsa051680.89698174
61Toxoplasmosis_Homo sapiens_hsa051450.89540084
62Measles_Homo sapiens_hsa051620.88336576
63Legionellosis_Homo sapiens_hsa051340.85017534
64Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.84489648
65T cell receptor signaling pathway_Homo sapiens_hsa046600.84259678
66Vitamin B6 metabolism_Homo sapiens_hsa007500.84197961
67Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.81927279
68Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.80632808
69Nucleotide excision repair_Homo sapiens_hsa034200.77307938
70Hepatitis C_Homo sapiens_hsa051600.77140659
71Antigen processing and presentation_Homo sapiens_hsa046120.76510710
72Oocyte meiosis_Homo sapiens_hsa041140.76282547
73African trypanosomiasis_Homo sapiens_hsa051430.74829189
74Fat digestion and absorption_Homo sapiens_hsa049750.74328347
75Long-term potentiation_Homo sapiens_hsa047200.74307513
76Peroxisome_Homo sapiens_hsa041460.73530070
77Dopaminergic synapse_Homo sapiens_hsa047280.71796487
78RNA transport_Homo sapiens_hsa030130.71285098
79Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.70955867
80Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.70507815
81Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.70197974
82Morphine addiction_Homo sapiens_hsa050320.68810079
83VEGF signaling pathway_Homo sapiens_hsa043700.68389982
84Epstein-Barr virus infection_Homo sapiens_hsa051690.68025247
85Phototransduction_Homo sapiens_hsa047440.67775073
86Pentose phosphate pathway_Homo sapiens_hsa000300.67717339
87Taste transduction_Homo sapiens_hsa047420.66834348
88Carbohydrate digestion and absorption_Homo sapiens_hsa049730.65267206
89Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.65196889
90Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.65182542
91Circadian entrainment_Homo sapiens_hsa047130.63230068
92Apoptosis_Homo sapiens_hsa042100.63210119
93Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.62825017
94Regulation of autophagy_Homo sapiens_hsa041400.61307406
95Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.59603516
96Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.58782368
97GABAergic synapse_Homo sapiens_hsa047270.58302064
98Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.57900716
99Autoimmune thyroid disease_Homo sapiens_hsa053200.57252449
100Hepatitis B_Homo sapiens_hsa051610.56443519
101DNA replication_Homo sapiens_hsa030300.55467073
102Jak-STAT signaling pathway_Homo sapiens_hsa046300.54993882
103Cocaine addiction_Homo sapiens_hsa050300.54771613
104Linoleic acid metabolism_Homo sapiens_hsa005910.54688349
105Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.54580742
106Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.54512915
107Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.54432025
108Carbon metabolism_Homo sapiens_hsa012000.54273472
109Folate biosynthesis_Homo sapiens_hsa007900.53450937
110Base excision repair_Homo sapiens_hsa034100.52128623
111Serotonergic synapse_Homo sapiens_hsa047260.51417954
112Insulin secretion_Homo sapiens_hsa049110.50951694
113Tyrosine metabolism_Homo sapiens_hsa003500.50926162
114Metabolic pathways_Homo sapiens_hsa011000.50564287
115Leukocyte transendothelial migration_Homo sapiens_hsa046700.50505033
116Homologous recombination_Homo sapiens_hsa034400.49081419
117N-Glycan biosynthesis_Homo sapiens_hsa005100.49061770
118Mineral absorption_Homo sapiens_hsa049780.48682797
119Salmonella infection_Homo sapiens_hsa051320.47836770
120Asthma_Homo sapiens_hsa053100.47065663
121Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.46150929
122Arachidonic acid metabolism_Homo sapiens_hsa005900.45958045
123Calcium signaling pathway_Homo sapiens_hsa040200.44633506
124Ether lipid metabolism_Homo sapiens_hsa005650.42107962
125Cysteine and methionine metabolism_Homo sapiens_hsa002700.40876988
126Glucagon signaling pathway_Homo sapiens_hsa049220.40756134
127RNA degradation_Homo sapiens_hsa030180.40482667
128Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.38406119
129Alcoholism_Homo sapiens_hsa050340.37615598
130Intestinal immune network for IgA production_Homo sapiens_hsa046720.37426693
131Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.36436921
132Renin secretion_Homo sapiens_hsa049240.35066465
133alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.34301655
134Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.32056270
135Fanconi anemia pathway_Homo sapiens_hsa034600.30284730
136Mismatch repair_Homo sapiens_hsa034300.28861871
137Glutamatergic synapse_Homo sapiens_hsa047240.28813854
138Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.28795720
139Other glycan degradation_Homo sapiens_hsa005110.28010981
140Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.27877772
141Shigellosis_Homo sapiens_hsa051310.27816079
142Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.27514097
143Primary immunodeficiency_Homo sapiens_hsa053400.26320505
144Fatty acid elongation_Homo sapiens_hsa000620.24550770
145Cholinergic synapse_Homo sapiens_hsa047250.24412608
146Galactose metabolism_Homo sapiens_hsa000520.23840937
147Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.23698778
148Glutathione metabolism_Homo sapiens_hsa004800.23250103
149Sulfur relay system_Homo sapiens_hsa041220.22989121
150Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.20564332
151Phenylalanine metabolism_Homo sapiens_hsa003600.19824793

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »