PPP1R12A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Myosin phosphatase target subunit 1, which is also called the myosin-binding subunit of myosin phosphatase, is one of the subunits of myosin phosphatase. Myosin phosphatase regulates the interaction of actin and myosin downstream of the guanosine triphosphatase Rho. The small guanosine triphosphatase Rho is implicated in myosin light chain (MLC) phosphorylation, which results in contraction of smooth muscle and interaction of actin and myosin in nonmuscle cells. The guanosine triphosphate (GTP)-bound, active form of RhoA (GTP.RhoA) specifically interacted with the myosin-binding subunit (MBS) of myosin phosphatase, which regulates the extent of phosphorylation of MLC. Rho-associated kinase (Rho-kinase), which is activated by GTP. RhoA, phosphorylated MBS and consequently inactivated myosin phosphatase. Overexpression of RhoA or activated RhoA in NIH 3T3 cells increased phosphorylation of MBS and MLC. Thus, Rho appears to inhibit myosin phosphatase through the action of Rho-kinase. Several transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1histone H3-K4 trimethylation (GO:0080182)5.33619080
2DNA double-strand break processing (GO:0000729)4.28079392
3regulation of meiosis I (GO:0060631)4.25325373
4histone mRNA catabolic process (GO:0071044)3.79742330
5replication fork processing (GO:0031297)3.74426090
6regulation of centriole replication (GO:0046599)3.64312829
7centriole replication (GO:0007099)3.52809677
8negative regulation of cell killing (GO:0031342)3.42462327
9negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.42462327
10nuclear pore complex assembly (GO:0051292)3.41617856
11regulation of mitotic spindle checkpoint (GO:1903504)3.35550689
12regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.35550689
13peptidyl-lysine trimethylation (GO:0018023)3.28608269
14establishment of protein localization to Golgi (GO:0072600)3.26311088
15pericardium development (GO:0060039)3.25142725
16retinal cone cell development (GO:0046549)3.17672534
17microtubule anchoring (GO:0034453)3.13031205
18histone H3-K4 methylation (GO:0051568)3.12562398
19RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.11075610
20mitotic sister chromatid cohesion (GO:0007064)3.08030565
21protein prenylation (GO:0018342)3.07030402
22prenylation (GO:0097354)3.07030402
23phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.04672827
24rRNA catabolic process (GO:0016075)3.04041826
25attachment of spindle microtubules to kinetochore (GO:0008608)2.99086118
26histone exchange (GO:0043486)2.98335548
27protein K11-linked deubiquitination (GO:0035871)2.97312206
28cytoplasmic mRNA processing body assembly (GO:0033962)2.96595698
29chromatin remodeling at centromere (GO:0031055)2.96289794
30CENP-A containing nucleosome assembly (GO:0034080)2.95379194
31neural tube formation (GO:0001841)2.93843966
32retrograde transport, vesicle recycling within Golgi (GO:0000301)2.93481375
33spindle checkpoint (GO:0031577)2.88869730
34histone H3-K9 methylation (GO:0051567)2.84841059
35maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.80355883
36negative regulation of necroptotic process (GO:0060546)2.79874793
37mitotic chromosome condensation (GO:0007076)2.79353915
38regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.77326618
39regulation of mitotic metaphase/anaphase transition (GO:0030071)2.77326618
40mitotic G2/M transition checkpoint (GO:0044818)2.75523753
41regulation of sister chromatid segregation (GO:0033045)2.74281704
42regulation of mitotic sister chromatid separation (GO:0010965)2.74281704
43regulation of mitotic sister chromatid segregation (GO:0033047)2.74281704
44mitotic spindle checkpoint (GO:0071174)2.72042956
45negative regulation of fibroblast apoptotic process (GO:2000270)2.71605328
46synapsis (GO:0007129)2.70862212
47negative T cell selection (GO:0043383)2.68831085
48negative regulation of DNA recombination (GO:0045910)2.68410369
49double-strand break repair via homologous recombination (GO:0000724)2.68265499
50antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.68136976
51recombinational repair (GO:0000725)2.67546435
52pore complex assembly (GO:0046931)2.67171656
53regulation of telomere maintenance (GO:0032204)2.66210253
54nuclear pore organization (GO:0006999)2.66186116
55kinetochore assembly (GO:0051382)2.65903120
56negative regulation of mitotic sister chromatid segregation (GO:0033048)2.64008947
57negative regulation of mitotic sister chromatid separation (GO:2000816)2.64008947
58negative regulation of sister chromatid segregation (GO:0033046)2.64008947
59negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.64008947
60negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.64008947
61T-helper cell differentiation (GO:0042093)2.61790597
62CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.61790597
63ncRNA catabolic process (GO:0034661)2.61765240
64negative thymic T cell selection (GO:0045060)2.61666425
65presynaptic membrane assembly (GO:0097105)2.61115021
66mitotic G2 DNA damage checkpoint (GO:0007095)2.59858346
67positive regulation of T cell cytokine production (GO:0002726)2.58796065
68postreplication repair (GO:0006301)2.58612946
69regulation of gamma-delta T cell differentiation (GO:0045586)2.58166433
70response to X-ray (GO:0010165)2.57214611
71telomere maintenance via telomerase (GO:0007004)2.57086351
72negative regulation of DNA repair (GO:0045738)2.55738947
73positive T cell selection (GO:0043368)2.55711262
74histone mRNA metabolic process (GO:0008334)2.55112730
75positive thymic T cell selection (GO:0045059)2.52003604
76regulation of necroptotic process (GO:0060544)2.51850187
77positive regulation of gamma-delta T cell activation (GO:0046645)2.51685416
78regulation of establishment of cell polarity (GO:2000114)2.51640862
79negative regulation of chromosome segregation (GO:0051985)2.51476590
80regulation of centrosome duplication (GO:0010824)2.50652297
81piRNA metabolic process (GO:0034587)2.50560508
82somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.49347285
83isotype switching (GO:0045190)2.49347285
84somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.49347285
85regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.47993660
86genitalia morphogenesis (GO:0035112)2.47641784
87regulation of fibroblast apoptotic process (GO:2000269)2.47611623
88metaphase plate congression (GO:0051310)2.47528339
89regulation of gamma-delta T cell activation (GO:0046643)2.46870682
90regulation of nuclear cell cycle DNA replication (GO:0033262)2.46782059
91mitotic spindle assembly checkpoint (GO:0007094)2.46493886
92positive regulation of protein autophosphorylation (GO:0031954)2.46040613
93spindle assembly checkpoint (GO:0071173)2.44650115
94resolution of meiotic recombination intermediates (GO:0000712)2.43721604
95regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.43321850
96histone-serine phosphorylation (GO:0035404)2.42793084
97protein K63-linked deubiquitination (GO:0070536)2.42573573
98regulation of acyl-CoA biosynthetic process (GO:0050812)2.42336446
99histone H3-K9 modification (GO:0061647)2.42259922
100epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.42227132
101* microtubule organizing center organization (GO:0031023)2.40947694
102acrosome assembly (GO:0001675)2.40794305
103protein localization to kinetochore (GO:0034501)2.40533677
104establishment of chromosome localization (GO:0051303)2.39736882
105regulation of histone H3-K9 methylation (GO:0051570)2.39186978
106reciprocal DNA recombination (GO:0035825)2.38573904
107regulation of DNA endoreduplication (GO:0032875)2.37183384
108histone H3-K36 demethylation (GO:0070544)2.36867289
109sister chromatid cohesion (GO:0007062)2.36532008
110meiotic chromosome segregation (GO:0045132)2.32159025
111regulation of interleukin-12 biosynthetic process (GO:0045075)2.31579050
112T cell selection (GO:0045058)2.31424940
113positive regulation of histone H3-K4 methylation (GO:0051571)2.31007220
114regulation of T cell tolerance induction (GO:0002664)2.30391960
115thymic T cell selection (GO:0045061)2.30010407
116alpha-beta T cell differentiation involved in immune response (GO:0002293)2.28543264
117alpha-beta T cell activation involved in immune response (GO:0002287)2.28543264
118T cell differentiation involved in immune response (GO:0002292)2.28543264
119cellular response to interleukin-15 (GO:0071350)2.28182294
120regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.27080849
121I-kappaB phosphorylation (GO:0007252)2.26915943
122positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.25776021
123positive regulation of mitotic sister chromatid separation (GO:1901970)2.25776021
124positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.25776021
125regulation of mitotic spindle organization (GO:0060236)2.25087170
126histone lysine methylation (GO:0034968)2.22362474
127regulation of RNA export from nucleus (GO:0046831)2.20371580
128myoblast migration (GO:0051451)2.19588663
129kinetochore organization (GO:0051383)2.17850844
130monoubiquitinated protein deubiquitination (GO:0035520)2.17186825
131hepatocyte apoptotic process (GO:0097284)2.15584401
132CD4-positive, alpha-beta T cell differentiation (GO:0043367)2.15150897
133face morphogenesis (GO:0060325)2.14128019
134fibroblast migration (GO:0010761)2.13070918
135regulation of transforming growth factor beta2 production (GO:0032909)2.11110104
136establishment of endothelial barrier (GO:0061028)2.09273734
137NIK/NF-kappaB signaling (GO:0038061)2.08804072
138positive regulation of cardiac muscle cell differentiation (GO:2000727)2.08694239
139positive regulation of transcription elongation from RNA polymerase II promoter (GO:0032968)2.06938969
140regulation of establishment or maintenance of cell polarity (GO:0032878)2.06163007
141negative regulation of DNA-dependent DNA replication (GO:2000104)2.04030732
142peptidyl-lysine methylation (GO:0018022)2.03942346
143alpha-beta T cell differentiation (GO:0046632)2.03259608
144positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.03212534
145positive regulation of interleukin-2 production (GO:0032743)2.01576869
146regulation of sister chromatid cohesion (GO:0007063)2.00402174
147negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.00271555
148negative regulation of translation, ncRNA-mediated (GO:0040033)2.00271555
149regulation of translation, ncRNA-mediated (GO:0045974)2.00271555
150corticosteroid receptor signaling pathway (GO:0031958)1.99818527
151histone lysine demethylation (GO:0070076)1.99800204
152interkinetic nuclear migration (GO:0022027)1.99732226
153negative regulation of necrotic cell death (GO:0060547)1.97279948
154response to interleukin-15 (GO:0070672)1.97162415
155Notch signaling involved in heart development (GO:0061314)1.95429890
156alpha-beta T cell activation (GO:0046631)1.95155824
157regulation of B cell receptor signaling pathway (GO:0050855)1.95102192
158heterotypic cell-cell adhesion (GO:0034113)1.94740787
159interferon-gamma production (GO:0032609)1.94566798
160DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla1.93660946
161positive regulation of interleukin-2 biosynthetic process (GO:0045086)1.92779648
162histone demethylation (GO:0016577)1.92696564
163regulation of T cell cytokine production (GO:0002724)1.92565678
164tyrosine phosphorylation of STAT protein (GO:0007260)1.91671768
165regulation of histone H3-K4 methylation (GO:0051569)1.91462618
166growth hormone receptor signaling pathway (GO:0060396)1.91208775
167protein targeting to Golgi (GO:0000042)1.90672685
168cardiac myofibril assembly (GO:0055003)1.89775063
169regulation of nucleobase-containing compound transport (GO:0032239)1.88914054
170cell fate commitment involved in formation of primary germ layer (GO:0060795)1.88550084
171leukocyte aggregation (GO:0070486)1.88155011
172cellular extravasation (GO:0045123)1.87794469
173regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 1.86491570
174leukocyte tethering or rolling (GO:0050901)1.84310251
175platelet-derived growth factor receptor signaling pathway (GO:0048008)1.83364207
176regulation of spindle organization (GO:0090224)1.83274024
177negative regulation of thymocyte apoptotic process (GO:0070244)1.83245731
178CD4-positive, alpha-beta T cell activation (GO:0035710)1.81996975

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.61491292
2SMAD_19615063_ChIP-ChIP_OVARY_Human3.67898833
3E2F7_22180533_ChIP-Seq_HELA_Human3.63791072
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.34309275
5CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.86638428
6FOXM1_23109430_ChIP-Seq_U2OS_Human2.69383245
7TP53_16413492_ChIP-PET_HCT116_Human2.54460597
8* STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.53500236
9SALL1_21062744_ChIP-ChIP_HESCs_Human2.52643151
10GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.51557483
11NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.29916383
12EGR1_19374776_ChIP-ChIP_THP-1_Human2.25615830
13VDR_22108803_ChIP-Seq_LS180_Human2.20838991
14TAF15_26573619_Chip-Seq_HEK293_Human2.20632195
15ZNF274_21170338_ChIP-Seq_K562_Hela2.18854364
16TP63_19390658_ChIP-ChIP_HaCaT_Human2.17014783
17BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.09415562
18FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.00479122
19FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.86778165
20IGF1R_20145208_ChIP-Seq_DFB_Human1.85562349
21RUNX_20019798_ChIP-Seq_JUKART_Human1.84799828
22POU3F2_20337985_ChIP-ChIP_501MEL_Human1.83713814
23BP1_19119308_ChIP-ChIP_Hs578T_Human1.82395666
24ZNF217_24962896_ChIP-Seq_MCF-7_Human1.75373260
25* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.73816511
26CDX2_19796622_ChIP-Seq_MESCs_Mouse1.71724370
27TCF4_18268006_ChIP-ChIP_LS174T_Human1.66074321
28CTBP2_25329375_ChIP-Seq_LNCAP_Human1.65849323
29* ELK1_19687146_ChIP-ChIP_HELA_Human1.63352586
30SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.62011788
31IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.59879316
32GBX2_23144817_ChIP-Seq_PC3_Human1.54050786
33* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.51675207
34FUS_26573619_Chip-Seq_HEK293_Human1.51156507
35WT1_19549856_ChIP-ChIP_CCG9911_Human1.49825180
36* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.49345797
37MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.48433594
38* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.45478689
39POU5F1_16153702_ChIP-ChIP_HESCs_Human1.45136135
40IRF8_21731497_ChIP-ChIP_J774_Mouse1.45068175
41* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.43377959
42NFE2_27457419_Chip-Seq_LIVER_Mouse1.43253255
43* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.41993283
44SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.41524902
45AR_25329375_ChIP-Seq_VCAP_Human1.41101974
46VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.41065697
47CTBP1_25329375_ChIP-Seq_LNCAP_Human1.39749957
48SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.39670081
49AR_21572438_ChIP-Seq_LNCaP_Human1.39033361
50IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.38634115
51CBP_20019798_ChIP-Seq_JUKART_Human1.38634115
52EWS_26573619_Chip-Seq_HEK293_Human1.36862462
53* TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.35872198
54HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.34391032
55* BRD4_25478319_ChIP-Seq_HGPS_Human1.34003779
56FLI1_27457419_Chip-Seq_LIVER_Mouse1.33819720
57RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.33566561
58E2F4_17652178_ChIP-ChIP_JURKAT_Human1.33400651
59* TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.33125490
60* POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.33125490
61PIAS1_25552417_ChIP-Seq_VCAP_Human1.31944624
62EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.31532813
63CJUN_26792858_Chip-Seq_BT549_Human1.29555126
64* FLI1_21867929_ChIP-Seq_TH2_Mouse1.28994123
65EZH2_22144423_ChIP-Seq_EOC_Human1.28140661
66* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.27396322
67* CRX_20693478_ChIP-Seq_RETINA_Mouse1.26935557
68MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.26529404
69P53_22387025_ChIP-Seq_ESCs_Mouse1.25853921
70* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.25039186
71* EP300_21415370_ChIP-Seq_HL-1_Mouse1.24524455
72CTNNB1_20460455_ChIP-Seq_HCT116_Human1.23011613
73* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.20990887
74TCF4_22108803_ChIP-Seq_LS180_Human1.20337760
75NR3C1_21868756_ChIP-Seq_MCF10A_Human1.20053062
76* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.19592412
77STAT3_23295773_ChIP-Seq_U87_Human1.19407466
78ARNT_22903824_ChIP-Seq_MCF-7_Human1.19262039
79PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.19168477
80ESR1_20079471_ChIP-ChIP_T-47D_Human1.19104876
81* OCT4_21477851_ChIP-Seq_ESCs_Mouse1.18925148
82NOTCH1_21737748_ChIP-Seq_TLL_Human1.18905047
83RUNX2_22187159_ChIP-Seq_PCA_Human1.18758192
84IRF8_27001747_Chip-Seq_BMDM_Mouse1.18479012
85AHR_22903824_ChIP-Seq_MCF-7_Human1.18354362
86VDR_24787735_ChIP-Seq_THP-1_Human1.16822252
87MYB_26560356_Chip-Seq_TH2_Human1.16622025
88FOXO3_23340844_ChIP-Seq_DLD1_Human1.16465962
89TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.14893851
90CMYC_18555785_Chip-Seq_ESCs_Mouse1.14467529
91SUZ12_18555785_Chip-Seq_ESCs_Mouse1.14312100
92CDX2_22108803_ChIP-Seq_LS180_Human1.13770850
93* TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.13556777
94HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.13297492
95SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.12940443
96FOXM1_26456572_ChIP-Seq_MCF-7_Human1.12881045
97TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.12734816
98NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.11416444
99PCGF2_27294783_Chip-Seq_ESCs_Mouse1.10687476
100* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.10012593
101* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.10012593
102EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.09264623
103* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.08234930
104Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.07924684
105SMAD4_21799915_ChIP-Seq_A2780_Human1.07551355
106NANOG_18555785_Chip-Seq_ESCs_Mouse1.07310827
107GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07255230
108MYB_26560356_Chip-Seq_TH1_Human1.06681085
109P300_18555785_Chip-Seq_ESCs_Mouse1.06098666
110IRF1_19129219_ChIP-ChIP_H3396_Human1.05631868
111ZFP57_27257070_Chip-Seq_ESCs_Mouse1.05298575
112MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.04932410
113STAT6_21828071_ChIP-Seq_BEAS2B_Human1.04270298
114MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.03772852
115PRDM14_20953172_ChIP-Seq_ESCs_Human1.03675288
116BCAT_22108803_ChIP-Seq_LS180_Human1.03345943
117ISL1_27105846_Chip-Seq_CPCs_Mouse1.03266890
118GATA2_21666600_ChIP-Seq_HMVEC_Human1.02806219
119SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.02176014
120SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.02176014
121RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.01712782
122EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.01401458
123TCF4_23295773_ChIP-Seq_U87_Human1.01351894
124STAT3_18555785_Chip-Seq_ESCs_Mouse1.01287404
125TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.00825290
126E2F1_18555785_Chip-Seq_ESCs_Mouse0.99621890
127TBX3_20139965_ChIP-Seq_ESCs_Mouse0.99598753
128PCGF2_27294783_Chip-Seq_NPCs_Mouse0.99325852
129CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.99289337
130EZH2_27294783_Chip-Seq_NPCs_Mouse0.99166897
131TP53_18474530_ChIP-ChIP_U2OS_Human0.99150866
132* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.98849552
133TBX3_20139965_ChIP-Seq_MESCs_Mouse0.98754277
134FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.98374963
135P300_19829295_ChIP-Seq_ESCs_Human0.96659903
136PPAR_26484153_Chip-Seq_NCI-H1993_Human0.95695302
137RBPJ_22232070_ChIP-Seq_NCS_Mouse0.95425043
138STAT4_19710469_ChIP-ChIP_TH1__Mouse0.95080928
139SMRT_27268052_Chip-Seq_Bcells_Human0.93068305
140* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.92913308
141SMAD3_21741376_ChIP-Seq_EPCs_Human0.91262268
142SUZ12_27294783_Chip-Seq_NPCs_Mouse0.90571006
143* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.87038998
144SPI1_23127762_ChIP-Seq_K562_Human0.86192383
145ER_23166858_ChIP-Seq_MCF-7_Human0.85219283
146TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.84690489
147* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.83779762
148SMAD3_21741376_ChIP-Seq_HESCs_Human0.83639036
149IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.82994701

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002009_preneoplasia3.70035575
2MP0003787_abnormal_imprinting3.61303380
3MP0003890_abnormal_embryonic-extraembry2.89560866
4MP0003300_gastrointestinal_ulcer2.69576962
5MP0008058_abnormal_DNA_repair2.59224535
6MP0008877_abnormal_DNA_methylation2.49709305
7MP0000569_abnormal_digit_pigmentation2.42106126
8MP0002006_tumorigenesis2.41554715
9MP0002166_altered_tumor_susceptibility2.41269437
10MP0006292_abnormal_olfactory_placode2.27199819
11MP0003045_fibrosis2.01099175
12MP0000427_abnormal_hair_cycle2.00402290
13MP0003121_genomic_imprinting2.00102605
14MP0003828_pulmonary_edema1.96428929
15MP0003950_abnormal_plasma_membrane1.96397074
16MP0003763_abnormal_thymus_physiology1.80880998
17MP0006072_abnormal_retinal_apoptosis1.78568998
18MP0003566_abnormal_cell_adhesion1.74410325
19MP0001188_hyperpigmentation1.72959021
20MP0002736_abnormal_nociception_after1.65451695
21MP0005187_abnormal_penis_morphology1.62968145
22MP0005174_abnormal_tail_pigmentation1.61242736
23MP0005671_abnormal_response_to1.55873377
24MP0008438_abnormal_cutaneous_collagen1.55237609
25MP0004215_abnormal_myocardial_fiber1.54410357
26MP0004808_abnormal_hematopoietic_stem1.52721323
27MP0002396_abnormal_hematopoietic_system1.52186282
28MP0003941_abnormal_skin_development1.52144503
29MP0003303_peritoneal_inflammation1.51025862
30MP0003091_abnormal_cell_migration1.50414230
31MP0004510_myositis1.46083024
32MP0009697_abnormal_copulation1.40549145
33MP0003283_abnormal_digestive_organ1.39219198
34MP0000767_abnormal_smooth_muscle1.37481047
35MP0008057_abnormal_DNA_replication1.37198587
36MP0003937_abnormal_limbs/digits/tail_de1.35244055
37MP0001790_abnormal_immune_system1.33596629
38MP0005387_immune_system_phenotype1.33596629
39MP0001293_anophthalmia1.30403617
40MP0001800_abnormal_humoral_immune1.30186354
41MP0003880_abnormal_central_pattern1.30071483
42MP0003718_maternal_effect1.28751762
43MP0004134_abnormal_chest_morphology1.28346490
44MP0005076_abnormal_cell_differentiation1.27744935
45MP0000516_abnormal_urinary_system1.26320406
46MP0005367_renal/urinary_system_phenotyp1.26320406
47MP0005623_abnormal_meninges_morphology1.26001880
48MP0010352_gastrointestinal_tract_polyps1.23851819
49MP0010307_abnormal_tumor_latency1.23508628
50MP0004145_abnormal_muscle_electrophysio1.23325969
51MP0002751_abnormal_autonomic_nervous1.21675209
52MP0005257_abnormal_intraocular_pressure1.21527683
53MP0005310_abnormal_salivary_gland1.19671722
54MP0005253_abnormal_eye_physiology1.19206364
55MP0003077_abnormal_cell_cycle1.19204633
56MP0001835_abnormal_antigen_presentation1.18230695
57MP0010155_abnormal_intestine_physiology1.18087786
58MP0003786_premature_aging1.17411137
59MP0005084_abnormal_gallbladder_morpholo1.16844877
60MP0002233_abnormal_nose_morphology1.13474978
61MP0002452_abnormal_antigen_presenting1.12275994
62MP0003448_altered_tumor_morphology1.11929409
63MP0001177_atelectasis1.11733401
64MP0002420_abnormal_adaptive_immunity1.11023300
65MP0001819_abnormal_immune_cell1.10565977
66MP0005395_other_phenotype1.09899394
67MP0002168_other_aberrant_phenotype1.09263785
68MP0002102_abnormal_ear_morphology1.07265773
69MP0005451_abnormal_body_composition1.06878943
70MP0003943_abnormal_hepatobiliary_system1.06761640
71MP0004185_abnormal_adipocyte_glucose1.06398879
72MP0002398_abnormal_bone_marrow1.06151032
73MP0002938_white_spotting1.04431627
74MP0005000_abnormal_immune_tolerance1.03595503
75MP0005551_abnormal_eye_electrophysiolog1.02993041
76MP0010630_abnormal_cardiac_muscle1.02340996
77MP0010094_abnormal_chromosome_stability1.02012330
78MP0000383_abnormal_hair_follicle1.01768427
79MP0002925_abnormal_cardiovascular_devel1.01405658
80MP0000778_abnormal_nervous_system1.01375216
81MP0003436_decreased_susceptibility_to1.01233544
82MP0001286_abnormal_eye_development1.00323567
83MP0000703_abnormal_thymus_morphology1.00141371
84MP0000733_abnormal_muscle_development1.00065860
85MP0002723_abnormal_immune_serum0.98539118
86MP0009384_cardiac_valve_regurgitation0.96142390
87MP0004272_abnormal_basement_membrane0.96007735
88MP0003122_maternal_imprinting0.95863917
89MP0000685_abnormal_immune_system0.95745146
90MP0001119_abnormal_female_reproductive0.95533624
91MP0002638_abnormal_pupillary_reflex0.95516378
92MP0003385_abnormal_body_wall0.95456636
93MP0004264_abnormal_extraembryonic_tissu0.95302104
94MP0000015_abnormal_ear_pigmentation0.94003395
95MP0009250_abnormal_appendicular_skeleto0.93740305
96MP0005646_abnormal_pituitary_gland0.93259490
97MP0000647_abnormal_sebaceous_gland0.93202451
98MP0009703_decreased_birth_body0.93049648
99MP0003866_abnormal_defecation0.92620936
100MP0004957_abnormal_blastocyst_morpholog0.91397260
101MP0002405_respiratory_system_inflammati0.89911678
102MP0000432_abnormal_head_morphology0.89771151
103MP0010678_abnormal_skin_adnexa0.89054399
104MP0004484_altered_response_of0.88828521
105MP0003567_abnormal_fetal_cardiomyocyte0.88771270
106MP0002933_joint_inflammation0.88111837
107MP0001968_abnormal_touch/_nociception0.88071058
108MP0003755_abnormal_palate_morphology0.87978343
109MP0003111_abnormal_nucleus_morphology0.87533703
110MP0001851_eye_inflammation0.87437424
111MP0004084_abnormal_cardiac_muscle0.87389052
112MP0001958_emphysema0.87293239
113MP0010386_abnormal_urinary_bladder0.87157264
114MP0000716_abnormal_immune_system0.86853432
115MP0002877_abnormal_melanocyte_morpholog0.86700953
116MP0000372_irregular_coat_pigmentation0.86055330
117MP0003123_paternal_imprinting0.84969694
118MP0003279_aneurysm0.84740775
119MP0003119_abnormal_digestive_system0.84653553
120MP0005503_abnormal_tendon_morphology0.84096339
121MP0002148_abnormal_hypersensitivity_rea0.83861578
122MP0004142_abnormal_muscle_tone0.83399136
123MP0002928_abnormal_bile_duct0.82316562
124MP0001486_abnormal_startle_reflex0.82282068
125MP0005275_abnormal_skin_tensile0.82053199
126MP0001929_abnormal_gametogenesis0.82015239
127MP0000631_abnormal_neuroendocrine_gland0.81557561
128MP0002084_abnormal_developmental_patter0.81237511
129MP0006138_congestive_heart_failure0.80489276
130MP0001485_abnormal_pinna_reflex0.80152268
131MP0000350_abnormal_cell_proliferation0.79684662
132MP0002109_abnormal_limb_morphology0.79511565
133MP0003935_abnormal_craniofacial_develop0.79478174
134MP0001533_abnormal_skeleton_physiology0.79381988
135MP0003252_abnormal_bile_duct0.78598626
136MP0002086_abnormal_extraembryonic_tissu0.78548533
137MP0005389_reproductive_system_phenotype0.77628380
138MP0003453_abnormal_keratinocyte_physiol0.77180781
139MP0005023_abnormal_wound_healing0.76954680
140MP0004883_abnormal_blood_vessel0.75572719
141MP0000653_abnormal_sex_gland0.75387348
142MP0006276_abnormal_autonomic_nervous0.75229884
143MP0008007_abnormal_cellular_replicative0.74734029
144MP0003984_embryonic_growth_retardation0.74425686
145MP0001784_abnormal_fluid_regulation0.73936407
146MP0000490_abnormal_crypts_of0.73790988
147MP0008775_abnormal_heart_ventricle0.73377851
148MP0002095_abnormal_skin_pigmentation0.73229862
149MP0008995_early_reproductive_senescence0.72831449
150MP0002210_abnormal_sex_determination0.72787825
151MP0002088_abnormal_embryonic_growth/wei0.72536216
152MP0005391_vision/eye_phenotype0.72164885
153MP0006054_spinal_hemorrhage0.72004985
154MP0002722_abnormal_immune_system0.71182441
155MP0005171_absent_coat_pigmentation0.70585121
156MP0008932_abnormal_embryonic_tissue0.68883568
157MP0009780_abnormal_chondrocyte_physiolo0.68346223
158MP0001879_abnormal_lymphatic_vessel0.68139554
159MP0000428_abnormal_craniofacial_morphol0.67320109
160MP0001919_abnormal_reproductive_system0.66752903
161MP0005380_embryogenesis_phenotype0.66485162
162MP0001672_abnormal_embryogenesis/_devel0.66485162
163MP0002998_abnormal_bone_remodeling0.66403197
164MP0008789_abnormal_olfactory_epithelium0.66041203
165MP0005075_abnormal_melanosome_morpholog0.63903491

Predicted human phenotypes

RankGene SetZ-score
1Volvulus (HP:0002580)4.61137889
2Aortic aneurysm (HP:0004942)4.37204882
3Aortic dissection (HP:0002647)3.63501743
4Abnormality of the fingertips (HP:0001211)3.52852033
5Abnormality of the labia minora (HP:0012880)3.27084841
6Absent frontal sinuses (HP:0002688)3.11990095
7Pancreatic cysts (HP:0001737)2.93172343
8Molar tooth sign on MRI (HP:0002419)2.72918290
9Abnormality of midbrain morphology (HP:0002418)2.72918290
10Aplasia/Hypoplasia of the uvula (HP:0010293)2.72771606
11Pancreatic fibrosis (HP:0100732)2.71490551
12Prostate neoplasm (HP:0100787)2.70845581
13Increased density of long bones (HP:0006392)2.60981225
14Bifid tongue (HP:0010297)2.56016215
15Chromsome breakage (HP:0040012)2.55549912
16Colon cancer (HP:0003003)2.51719371
17Stomach cancer (HP:0012126)2.48664794
18Fair hair (HP:0002286)2.46467421
19Arterial tortuosity (HP:0005116)2.38974256
20True hermaphroditism (HP:0010459)2.37405684
21Abnormal hair whorl (HP:0010721)2.35628208
22Spondylolisthesis (HP:0003302)2.34034788
23Meckel diverticulum (HP:0002245)2.33677057
24Abnormality of the ileum (HP:0001549)2.33252574
25Neoplasm of the adrenal cortex (HP:0100641)2.31753955
26Aplasia/Hypoplasia of the tongue (HP:0010295)2.30023556
27Aqueductal stenosis (HP:0002410)2.29781913
28Duodenal stenosis (HP:0100867)2.29663629
29Small intestinal stenosis (HP:0012848)2.29663629
30Cerebral aneurysm (HP:0004944)2.28636979
31Papillary thyroid carcinoma (HP:0002895)2.28130222
32Vascular tortuosity (HP:0004948)2.27446841
33Thyroid carcinoma (HP:0002890)2.25257797
34Deviation of the thumb (HP:0009603)2.23948528
35Bicuspid aortic valve (HP:0001647)2.23285853
36Aplasia/Hypoplasia of the tibia (HP:0005772)2.23078345
37Increased number of teeth (HP:0011069)2.22177985
38Protruding tongue (HP:0010808)2.20426160
39Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)2.20239137
40Embryonal renal neoplasm (HP:0011794)2.20065608
41Nephroblastoma (Wilms tumor) (HP:0002667)2.17992925
42Thyroiditis (HP:0100646)2.16723448
43Hyperventilation (HP:0002883)2.16174197
44Ankle contracture (HP:0006466)2.15322453
45Supernumerary spleens (HP:0009799)2.15205947
46Abnormal lung lobation (HP:0002101)2.15180475
47Retrobulbar optic neuritis (HP:0100654)2.14780193
48Optic neuritis (HP:0100653)2.14780193
49Clubbing of toes (HP:0100760)2.13580449
50Proximal placement of thumb (HP:0009623)2.13392140
51Lip pit (HP:0100267)2.13382857
52Long eyelashes (HP:0000527)2.10363498
53Abnormality of the phalanges of the 2nd finger (HP:0009541)2.08279406
54Hypoplastic labia majora (HP:0000059)2.08268070
55Abnormality of the renal cortex (HP:0011035)2.07190693
56Drooling (HP:0002307)2.06463565
57Aplasia/Hypoplasia of the hallux (HP:0008362)2.05767421
58Gaze-evoked nystagmus (HP:0000640)2.04280145
59T lymphocytopenia (HP:0005403)2.04120532
60Syringomyelia (HP:0003396)2.03877487
61Spinal cord lesions (HP:0100561)2.03877487
62Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.03593231
63Glioma (HP:0009733)2.03481007
64Intestinal atresia (HP:0011100)2.02985587
65Ectopic kidney (HP:0000086)2.01884505
66Nephronophthisis (HP:0000090)2.01778225
67Abnormality of the duodenum (HP:0002246)2.01593725
68Septo-optic dysplasia (HP:0100842)2.00137014
69Renal cortical cysts (HP:0000803)2.00102452
70Urethral obstruction (HP:0000796)1.98963999
71Chromosomal breakage induced by crosslinking agents (HP:0003221)1.98955092
72Abnormality of T cell number (HP:0011839)1.98717385
73Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.97675453
74Narrow forehead (HP:0000341)1.96914759
75Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.96432335
76Sloping forehead (HP:0000340)1.95217114
77Abnormality of the renal medulla (HP:0100957)1.95035813
78Short middle phalanx of the 5th finger (HP:0004220)1.94792481
79Aortic regurgitation (HP:0001659)1.93882266
80Medial flaring of the eyebrow (HP:0010747)1.92971595
81Abnormality of the nasal septum (HP:0000419)1.92482973
82Genital tract atresia (HP:0001827)1.92464338
83Acute myeloid leukemia (HP:0004808)1.92264672
84Neoplasm of the oral cavity (HP:0100649)1.92117791
85Deep philtrum (HP:0002002)1.90950238
86Rhabdomyosarcoma (HP:0002859)1.90212962
87Limited elbow extension (HP:0001377)1.89934091
88Chronic hepatic failure (HP:0100626)1.89814954
89Persistence of primary teeth (HP:0006335)1.89311665
90Median cleft lip (HP:0000161)1.88831860
91Gonadotropin excess (HP:0000837)1.88613093
92Labial hypoplasia (HP:0000066)1.88219214
93Abnormality of the preputium (HP:0100587)1.87598726
94Excessive salivation (HP:0003781)1.87230908
95Neoplasm of the small intestine (HP:0100833)1.86943923
96Preaxial foot polydactyly (HP:0001841)1.85966712
97Abnormality of the labia majora (HP:0012881)1.85749028
98Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.85053860
99Short 4th metacarpal (HP:0010044)1.85053860
100Abnormality of the ischium (HP:0003174)1.83730619
101Febrile seizures (HP:0002373)1.83551897
102Curly hair (HP:0002212)1.83394305
103Narrow palate (HP:0000189)1.83181537
104Abnormality of the right ventricle (HP:0001707)1.82318549
105Osteolytic defects of the phalanges of the hand (HP:0009771)1.82312692
106Osteolytic defects of the hand bones (HP:0009699)1.82312692
107Abnormality of the septum pellucidum (HP:0007375)1.82086256
108Abnormality of the frontal sinuses (HP:0002687)1.81962759
109Anencephaly (HP:0002323)1.81698912
110Absent speech (HP:0001344)1.80824884
111Severe combined immunodeficiency (HP:0004430)1.80293173
112Abnormality of the astrocytes (HP:0100707)1.79298860
113Astrocytoma (HP:0009592)1.79298860
114Dislocated radial head (HP:0003083)1.78936273
115Abnormality of the phalanges of the 5th finger (HP:0004213)1.78881314
116Trigonocephaly (HP:0000243)1.77986001
117Truncal obesity (HP:0001956)1.76642851
118Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.76587541
119Abnormality of incisor morphology (HP:0011063)1.76474953
120Progressive inability to walk (HP:0002505)1.76460693
121Blepharitis (HP:0000498)1.76328070
122Abnormality of chromosome stability (HP:0003220)1.75872474
123Medulloblastoma (HP:0002885)1.74472731
124Short tibia (HP:0005736)1.73553308
125Vaginal atresia (HP:0000148)1.73509862
126Growth hormone deficiency (HP:0000824)1.73363273
127Mitral valve prolapse (HP:0001634)1.73311343
128Shallow orbits (HP:0000586)1.72865127
129Aplasia cutis congenita (HP:0001057)1.72572183
130Oligodactyly (hands) (HP:0001180)1.70829612
131Postaxial hand polydactyly (HP:0001162)1.70779817
132Asymmetry of the thorax (HP:0001555)1.70603408
133Small hand (HP:0200055)1.70398627
134Biliary tract neoplasm (HP:0100574)1.69442833
135Papilledema (HP:0001085)1.68552910
136Limited hip movement (HP:0008800)1.68542759
137Aplasia/Hypoplasia of the sternum (HP:0006714)1.68305543
138Midline defect of the nose (HP:0004122)1.68295503
139Aneurysm (HP:0002617)1.68087543
140Preaxial hand polydactyly (HP:0001177)1.67921799
141Hip dysplasia (HP:0001385)1.67746406
142Low anterior hairline (HP:0000294)1.66693342
143Hypoplastic iliac wings (HP:0002866)1.65608613
144Astigmatism (HP:0000483)1.65248762
145Optic nerve hypoplasia (HP:0000609)1.64887985
146Arteriovenous malformation (HP:0100026)1.63845636
147Abnormality of the radial head (HP:0003995)1.62979349
148Submucous cleft hard palate (HP:0000176)1.62689581
149Hip contracture (HP:0003273)1.62597622
150Keratoconjunctivitis sicca (HP:0001097)1.61174436
151Pulmonary artery stenosis (HP:0004415)1.60935445
152Transitional cell carcinoma of the bladder (HP:0006740)1.59932852
153Chin dimple (HP:0010751)1.58352835
154Dilatation of the ascending aorta (HP:0005111)1.58067662
155Sparse lateral eyebrow (HP:0005338)1.57725635
156Sandal gap (HP:0001852)1.57665999
157Hypoplastic ischia (HP:0003175)1.57257782
158Recurrent fungal infections (HP:0002841)1.57093296
159Wrist flexion contracture (HP:0001239)1.55649568
160Arterial thrombosis (HP:0004420)1.55367716
161Myositis (HP:0100614)1.55195885
162Abnormality of the left ventricular outflow tract (HP:0011103)1.55074430
163Subaortic stenosis (HP:0001682)1.55074430
164Orchitis (HP:0100796)1.53652487
165Abnormality of the distal phalanx of the thumb (HP:0009617)1.53621809
166Increased nuchal translucency (HP:0010880)1.52261733
167Cutis marmorata (HP:0000965)1.51047410
168Supernumerary ribs (HP:0005815)1.50974597
169Recurrent viral infections (HP:0004429)1.48971214
170Ulnar bowing (HP:0003031)1.47778332
171Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.47580010
172Combined immunodeficiency (HP:0005387)1.47491055
173Heterotopia (HP:0002282)1.47322985
174Bladder carcinoma (HP:0002862)1.45974492
175Bladder neoplasm (HP:0009725)1.45974492
176Scapular winging (HP:0003691)1.44768837
177Aplasia/Hypoplasia of the earlobes (HP:0009906)1.44157942
178Long nose (HP:0003189)1.42962743
179Anal stenosis (HP:0002025)1.42673639
180Abnormality of the columella (HP:0009929)1.42443963
181Short hallux (HP:0010109)1.41886689
182Abnormal platelet volume (HP:0011876)1.41749441
183Abnormality of chromosome segregation (HP:0002916)1.41446032
184Keratoconjunctivitis (HP:0001096)1.41041236
185Prominent nose (HP:0000448)1.40625906

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS13.37738581
2STK38L3.36051684
3PIK3CA3.28445321
4CDK123.12266943
5ACVR1B2.86888117
6TNIK2.78562864
7TTN2.68135598
8CASK2.61509711
9MYLK2.55730271
10WNK32.49808072
11BMPR1B2.32501328
12EIF2AK32.29215881
13MST42.25560463
14PNCK2.12754208
15BRSK22.01882551
16TXK1.97856395
17MAPK131.92683266
18TEC1.88710281
19STK31.87042849
20FRK1.81875503
21STK101.75828719
22JAK31.72628542
23CDC71.71680122
24MAP3K71.67500723
25ZAK1.66276101
26TRPM71.65328590
27MAP3K141.62528909
28CDK91.61870195
29NEK61.56955213
30ERBB31.55545349
31TRIM281.52390789
32MKNK21.48390829
33TAOK31.43437733
34MELK1.39579185
35PDGFRB1.38654985
36BMPR21.38594723
37ITK1.38172390
38* NUAK11.35197375
39RIPK41.33693490
40STK391.31320295
41FGR1.28705659
42MAP3K41.25281566
43BCR1.24142983
44MAP3K131.24000945
45BRD41.21789107
46BUB11.20678160
47WEE11.19735747
48JAK11.15706000
49MAP4K21.13644654
50FGFR31.13525278
51CAMK1D1.10960619
52PAK21.08515624
53MAP3K61.06937929
54CHUK1.06059295
55OXSR11.05919998
56STK161.04198517
57STK41.01529807
58MAP4K11.01278262
59EEF2K1.01218611
60CCNB11.01056875
61CDK41.00377873
62* DMPK1.00158757
63IKBKE0.98827181
64MARK30.98823188
65CSK0.98208571
66EIF2AK10.96996307
67CAMK1G0.96731538
68EIF2AK20.94858444
69CHEK20.94554939
70PLK20.91374672
71PIK3CG0.89844480
72MARK20.89288618
73TGFBR10.88269751
74PINK10.86686654
75PTK2B0.84674823
76TTK0.81923754
77IKBKB0.80453785
78STK240.80387719
79MKNK10.79954287
80CLK10.79726877
81OBSCN0.79676673
82CDK30.77994505
83CDK60.76930358
84SRPK10.76907398
85STK380.76352152
86PIM10.76140632
87HCK0.75475928
88TSSK60.75202029
89TYK20.74770876
90LCK0.74124199
91ATM0.73164664
92PKN10.72919089
93PRKCE0.71637630
94CDK80.71361554
95AKT30.69090513
96YES10.67295133
97CHEK10.65790309
98BMX0.63775056
99PLK10.63419999
100VRK10.63361761
101AURKB0.60597403
102TGFBR20.60563565
103CDC42BPA0.58498172
104DYRK30.58478768
105NEK90.58040373
106WNK10.57496353
107ADRBK10.56355598
108PRKD20.56196922
109* PRKCQ0.56148925
110PRKAA20.54676756
111SGK10.53885853
112LATS20.53062967
113FGFR10.52809979
114CSF1R0.52338557
115RPS6KB20.51943609
116ERBB40.51896808
117ATR0.51034367
118FGFR20.50864125
119KSR10.50751011
120NLK0.50295262
121ABL10.49719994
122EPHA30.49715127
123NEK10.48980813
124MTOR0.46657720
125FES0.46511744
126GRK70.46469858
127MINK10.46418225
128PLK30.46111874
129MAP3K120.45374325
130MET0.45101853
131NEK20.45090130
132PAK30.42362206
133DYRK1A0.41478383
134SGK20.41046798
135* ROCK10.40795246
136INSRR0.40189551
137AKT10.39047890
138CAMKK20.38678942
139MAPK140.37895922
140FYN0.37063066
141ADRBK20.35925135
142EPHA40.35653069
143PLK40.35434604
144PDK20.34839915
145TAF10.33933949
146MAP2K70.33918998
147CSNK1G10.33787014
148GRK10.32291386
149IRAK10.31950161
150* PRKG10.31668995
151EGFR0.30685206
152FER0.29258817

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030602.77642636
2Pantothenate and CoA biosynthesis_Homo sapiens_hsa007702.14985979
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.02976205
4Adherens junction_Homo sapiens_hsa045201.83369749
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.79052659
6Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.61720004
7NF-kappa B signaling pathway_Homo sapiens_hsa040641.59399390
8Phototransduction_Homo sapiens_hsa047441.57939148
9Intestinal immune network for IgA production_Homo sapiens_hsa046721.57585234
10Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.55673191
11Propanoate metabolism_Homo sapiens_hsa006401.54288900
12Leishmaniasis_Homo sapiens_hsa051401.48021630
13RNA transport_Homo sapiens_hsa030131.44959440
14T cell receptor signaling pathway_Homo sapiens_hsa046601.40890326
15Leukocyte transendothelial migration_Homo sapiens_hsa046701.39037297
16MicroRNAs in cancer_Homo sapiens_hsa052061.38752312
17Mismatch repair_Homo sapiens_hsa034301.38487234
18Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.37287121
19Primary immunodeficiency_Homo sapiens_hsa053401.36796863
20NOD-like receptor signaling pathway_Homo sapiens_hsa046211.34849882
21Osteoclast differentiation_Homo sapiens_hsa043801.33447928
22Viral myocarditis_Homo sapiens_hsa054161.32147510
23Non-homologous end-joining_Homo sapiens_hsa034501.30519286
24Oocyte meiosis_Homo sapiens_hsa041141.28592898
25Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.28287301
26Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.25188872
27Measles_Homo sapiens_hsa051621.23605982
28Dilated cardiomyopathy_Homo sapiens_hsa054141.22279685
29Pancreatic cancer_Homo sapiens_hsa052121.22169052
30Small cell lung cancer_Homo sapiens_hsa052221.21653236
31Olfactory transduction_Homo sapiens_hsa047401.21179572
32Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.20919116
33* Focal adhesion_Homo sapiens_hsa045101.20177621
34TGF-beta signaling pathway_Homo sapiens_hsa043501.19664829
35Nucleotide excision repair_Homo sapiens_hsa034201.19535641
36Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.18257707
37* Regulation of actin cytoskeleton_Homo sapiens_hsa048101.16939531
38Graft-versus-host disease_Homo sapiens_hsa053321.16088882
39Toxoplasmosis_Homo sapiens_hsa051451.15807852
40Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.14881741
41ECM-receptor interaction_Homo sapiens_hsa045121.14443524
42Cell cycle_Homo sapiens_hsa041101.12641378
43Steroid biosynthesis_Homo sapiens_hsa001001.12176201
44Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.11773585
45Nicotine addiction_Homo sapiens_hsa050331.10812110
46TNF signaling pathway_Homo sapiens_hsa046681.08971381
47Allograft rejection_Homo sapiens_hsa053301.08603261
48Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.06822133
49Hedgehog signaling pathway_Homo sapiens_hsa043401.06558593
50* Platelet activation_Homo sapiens_hsa046111.06102780
51B cell receptor signaling pathway_Homo sapiens_hsa046621.05970064
52AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.04326632
53Chronic myeloid leukemia_Homo sapiens_hsa052201.03346484
54Hematopoietic cell lineage_Homo sapiens_hsa046401.01787942
55Transcriptional misregulation in cancer_Homo sapiens_hsa052021.00906068
56Autoimmune thyroid disease_Homo sapiens_hsa053201.00867560
57Herpes simplex infection_Homo sapiens_hsa051681.00287284
58Prostate cancer_Homo sapiens_hsa052150.98066568
59Shigellosis_Homo sapiens_hsa051310.96655361
60Hepatitis B_Homo sapiens_hsa051610.96450980
61Salmonella infection_Homo sapiens_hsa051320.95399515
62Toll-like receptor signaling pathway_Homo sapiens_hsa046200.94457379
63Jak-STAT signaling pathway_Homo sapiens_hsa046300.93979733
64Chemokine signaling pathway_Homo sapiens_hsa040620.93897038
65Regulation of autophagy_Homo sapiens_hsa041400.93433598
66Selenocompound metabolism_Homo sapiens_hsa004500.92803975
67* Proteoglycans in cancer_Homo sapiens_hsa052050.92423879
68Malaria_Homo sapiens_hsa051440.92107711
69RNA polymerase_Homo sapiens_hsa030200.90790956
70HTLV-I infection_Homo sapiens_hsa051660.90551876
71Tight junction_Homo sapiens_hsa045300.90112125
72Circadian entrainment_Homo sapiens_hsa047130.89776168
73Fanconi anemia pathway_Homo sapiens_hsa034600.89328693
74Nitrogen metabolism_Homo sapiens_hsa009100.88806420
75Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.88351686
76Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.87383927
77Colorectal cancer_Homo sapiens_hsa052100.85301208
78Dorso-ventral axis formation_Homo sapiens_hsa043200.85288626
79MAPK signaling pathway_Homo sapiens_hsa040100.84445288
80Endometrial cancer_Homo sapiens_hsa052130.84103987
81* Vascular smooth muscle contraction_Homo sapiens_hsa042700.83553939
82Antigen processing and presentation_Homo sapiens_hsa046120.83553225
83Hippo signaling pathway_Homo sapiens_hsa043900.83373435
84Pathways in cancer_Homo sapiens_hsa052000.82585318
85Renal cell carcinoma_Homo sapiens_hsa052110.82127097
86Circadian rhythm_Homo sapiens_hsa047100.82003484
87Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.81479477
88Phosphatidylinositol signaling system_Homo sapiens_hsa040700.81115201
89RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.80438339
90* cGMP-PKG signaling pathway_Homo sapiens_hsa040220.79669924
91Taste transduction_Homo sapiens_hsa047420.79376090
92Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.78743127
93p53 signaling pathway_Homo sapiens_hsa041150.78618184
94Viral carcinogenesis_Homo sapiens_hsa052030.78283982
95Butanoate metabolism_Homo sapiens_hsa006500.77843429
96Caffeine metabolism_Homo sapiens_hsa002320.77555384
97Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.77242219
98Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.77047623
99Amoebiasis_Homo sapiens_hsa051460.76924289
100Basal transcription factors_Homo sapiens_hsa030220.76891152
101Rap1 signaling pathway_Homo sapiens_hsa040150.76834962
102Choline metabolism in cancer_Homo sapiens_hsa052310.76314813
103Basal cell carcinoma_Homo sapiens_hsa052170.75761874
104Influenza A_Homo sapiens_hsa051640.75725728
105Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.75467360
106Renin secretion_Homo sapiens_hsa049240.74334002
107ErbB signaling pathway_Homo sapiens_hsa040120.73433863
108FoxO signaling pathway_Homo sapiens_hsa040680.72861799
109Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.72844017
110Serotonergic synapse_Homo sapiens_hsa047260.72691590
111* Oxytocin signaling pathway_Homo sapiens_hsa049210.72580373
112Wnt signaling pathway_Homo sapiens_hsa043100.72413317
113Apoptosis_Homo sapiens_hsa042100.71762241
114RNA degradation_Homo sapiens_hsa030180.71602661
115Notch signaling pathway_Homo sapiens_hsa043300.71353644
116Homologous recombination_Homo sapiens_hsa034400.70540136
117Dopaminergic synapse_Homo sapiens_hsa047280.70339109
118Thyroid hormone signaling pathway_Homo sapiens_hsa049190.69852292
119* cAMP signaling pathway_Homo sapiens_hsa040240.69134927
120Glioma_Homo sapiens_hsa052140.69124282
121Morphine addiction_Homo sapiens_hsa050320.68866869
122Melanoma_Homo sapiens_hsa052180.68239638
123Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.68082811
124Axon guidance_Homo sapiens_hsa043600.67814259
125Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.66537318
126VEGF signaling pathway_Homo sapiens_hsa043700.66318484
127Non-small cell lung cancer_Homo sapiens_hsa052230.65972248
128Tuberculosis_Homo sapiens_hsa051520.65582738
129Ras signaling pathway_Homo sapiens_hsa040140.65343284
130Long-term depression_Homo sapiens_hsa047300.64849205
131Phospholipase D signaling pathway_Homo sapiens_hsa040720.64450501
132African trypanosomiasis_Homo sapiens_hsa051430.64231593
133Spliceosome_Homo sapiens_hsa030400.63983383
134Prolactin signaling pathway_Homo sapiens_hsa049170.63781441
135Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.62880875
136mRNA surveillance pathway_Homo sapiens_hsa030150.62733100
137Acute myeloid leukemia_Homo sapiens_hsa052210.62717400
138Glutamatergic synapse_Homo sapiens_hsa047240.58561485
139Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.58023824
140Amphetamine addiction_Homo sapiens_hsa050310.57296499
141Calcium signaling pathway_Homo sapiens_hsa040200.57232254
142Proteasome_Homo sapiens_hsa030500.57181217
143Cholinergic synapse_Homo sapiens_hsa047250.56181751
144Salivary secretion_Homo sapiens_hsa049700.52640409
145GABAergic synapse_Homo sapiens_hsa047270.51190167
146Purine metabolism_Homo sapiens_hsa002300.50409100
147PI3K-Akt signaling pathway_Homo sapiens_hsa041510.47489110
148Gap junction_Homo sapiens_hsa045400.44519683
149Inositol phosphate metabolism_Homo sapiens_hsa005620.43242471
150Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.42092455
151Lysine degradation_Homo sapiens_hsa003100.41028181

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