PPP1R13L

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: IASPP is one of the most evolutionarily conserved inhibitors of p53 (TP53; MIM 191170), whereas ASPP1 (MIM 606455) and ASPP2 (MIM 602143) are activators of p53. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1desmosome organization (GO:0002934)9.07188565
2hemidesmosome assembly (GO:0031581)7.67637234
3bundle of His cell to Purkinje myocyte communication (GO:0086069)7.16147830
4* molting cycle (GO:0042303)6.71887294
5* hair cycle (GO:0042633)6.71887294
6sarcomere organization (GO:0045214)5.55691964
7regulation of water loss via skin (GO:0033561)5.51857741
8keratinization (GO:0031424)5.46870220
9establishment of skin barrier (GO:0061436)5.45840581
10plasma membrane repair (GO:0001778)5.22973495
11cardiac myofibril assembly (GO:0055003)5.15056206
12atrioventricular valve morphogenesis (GO:0003181)4.78361383
13cell-substrate junction assembly (GO:0007044)4.74151158
14skin morphogenesis (GO:0043589)4.69681590
15regulation of cardioblast differentiation (GO:0051890)4.54409621
16epithelial cell-cell adhesion (GO:0090136)4.35406057
17myofibril assembly (GO:0030239)4.31911161
18ventricular cardiac muscle cell action potential (GO:0086005)4.31902259
19negative regulation of potassium ion transmembrane transporter activity (GO:1901017)4.30616022
20muscle filament sliding (GO:0030049)4.25610450
21actin-myosin filament sliding (GO:0033275)4.25610450
22keratinocyte development (GO:0003334)4.11162655
23apoptotic process involved in morphogenesis (GO:0060561)4.05920063
24intermediate filament organization (GO:0045109)3.98574502
25keratinocyte differentiation (GO:0030216)3.91390166
26ventricular cardiac muscle tissue morphogenesis (GO:0055010)3.88192065
27peptide cross-linking (GO:0018149)3.86996741
28negative regulation of keratinocyte proliferation (GO:0010839)3.86720006
29cardiac muscle cell development (GO:0055013)3.86054342
30negative regulation of potassium ion transmembrane transport (GO:1901380)3.77256608
31cardiac cell development (GO:0055006)3.75068862
32cardiac muscle tissue morphogenesis (GO:0055008)3.74368804
33gap junction assembly (GO:0016264)3.72703062
34cytoskeletal anchoring at plasma membrane (GO:0007016)3.72480533
35planar cell polarity pathway involved in neural tube closure (GO:0090179)3.68014468
36wound healing, spreading of epidermal cells (GO:0035313)3.62931223
37actin-mediated cell contraction (GO:0070252)3.60110116
38establishment of tissue polarity (GO:0007164)3.59807607
39establishment of planar polarity (GO:0001736)3.59807607
40actomyosin structure organization (GO:0031032)3.58733270
41multicellular organismal water homeostasis (GO:0050891)3.56887669
42regulation of skeletal muscle contraction (GO:0014819)3.53500212
43endothelial cell chemotaxis (GO:0035767)3.52085347
44regulation of hippo signaling (GO:0035330)3.47577007
45ectoderm development (GO:0007398)3.44958363
46muscle tissue morphogenesis (GO:0060415)3.44668572
47regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.44289433
48semaphorin-plexin signaling pathway (GO:0071526)3.39821141
49endodermal cell differentiation (GO:0035987)3.32484819
50heart trabecula formation (GO:0060347)3.30631414
51negative regulation of cell fate specification (GO:0009996)3.30332847
52regulation of transforming growth factor beta2 production (GO:0032909)3.27563313
53epidermis development (GO:0008544)3.21258419
54keratinocyte proliferation (GO:0043616)3.16285798
55morphogenesis of embryonic epithelium (GO:0016331)3.15007587
56cell-substrate adherens junction assembly (GO:0007045)3.12882524
57focal adhesion assembly (GO:0048041)3.12882524
58* cardiac muscle contraction (GO:0060048)3.11574460
59tooth mineralization (GO:0034505)3.10793955
60lateral sprouting from an epithelium (GO:0060601)3.10678640
61regulation of keratinocyte proliferation (GO:0010837)3.09534618
62apoptotic process involved in development (GO:1902742)3.09132677
63epidermal cell differentiation (GO:0009913)3.07079266
64phosphatidylserine acyl-chain remodeling (GO:0036150)3.06596401
65cell communication involved in cardiac conduction (GO:0086065)3.05239623
66trabecula formation (GO:0060343)3.03753037
67regulation of gonadotropin secretion (GO:0032276)3.02897632
68heart valve morphogenesis (GO:0003179)3.01241553
69bone trabecula formation (GO:0060346)3.00085582
70adherens junction assembly (GO:0034333)2.99460782
71establishment or maintenance of monopolar cell polarity (GO:0061339)2.98654181
72establishment of monopolar cell polarity (GO:0061162)2.98654181
73adult heart development (GO:0007512)2.96298265
74cell junction maintenance (GO:0034331)2.93601850
75actin filament-based movement (GO:0030048)2.92852905
76regulation of apoptotic process involved in morphogenesis (GO:1902337)2.92511484
77positive regulation of epidermis development (GO:0045684)2.91405316
78Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.89569034
79protein heterotrimerization (GO:0070208)2.86708922
80wound healing, spreading of cells (GO:0044319)2.86631025
81activation of Rac GTPase activity (GO:0032863)2.85554098
82basement membrane organization (GO:0071711)2.84355214
83regulation of tight junction assembly (GO:2000810)2.83272653
84regulation of ruffle assembly (GO:1900027)2.82810207
85positive regulation of epidermal cell differentiation (GO:0045606)2.80795822
86renal filtration (GO:0097205)2.80433981
87water homeostasis (GO:0030104)2.80361841
88carnitine shuttle (GO:0006853)2.79699190
89peptidyl-proline hydroxylation (GO:0019511)2.78816767
90cellular response to lithium ion (GO:0071285)2.78400343
91regulation of endothelial cell chemotaxis (GO:2001026)2.78155533
924-hydroxyproline metabolic process (GO:0019471)2.76810630
93positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.76369600
94phosphatidylinositol acyl-chain remodeling (GO:0036149)2.75745193
95ventricular cardiac muscle cell development (GO:0055015)2.75558871
96regulation of establishment of planar polarity (GO:0090175)2.75375332
97regulation of p38MAPK cascade (GO:1900744)2.74157040
98positive regulation of transcription initiation from RNA polymerase II promoter (GO:0060261)2.72899321
99regulation of cell proliferation involved in kidney development (GO:1901722)2.72376809
100negative regulation of chondrocyte differentiation (GO:0032331)2.71001516
101eyelid development in camera-type eye (GO:0061029)2.70137990
102cell junction assembly (GO:0034329)2.70124724
103regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.69501739
104paraxial mesoderm development (GO:0048339)2.69286164
105cell-cell junction maintenance (GO:0045217)2.69262632
106polarized epithelial cell differentiation (GO:0030859)2.68347707
107adhesion of symbiont to host cell (GO:0044650)2.66769395
108virion attachment to host cell (GO:0019062)2.66769395
109dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.65595418
110interferon-gamma secretion (GO:0072643)2.65524627
111cell junction organization (GO:0034330)2.65049903
112skin development (GO:0043588)2.65001896
113regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.63401417
114positive regulation of myotube differentiation (GO:0010831)2.62385039
115outflow tract septum morphogenesis (GO:0003148)2.61985449
116negative regulation of striated muscle cell apoptotic process (GO:0010664)2.61958569
117cardiac conduction (GO:0061337)2.61825583
118regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.60130449
119positive regulation of fatty acid beta-oxidation (GO:0032000)2.59853578
120hippo signaling (GO:0035329)2.59340113
121regulation of hair follicle development (GO:0051797)2.58872196
122lung epithelium development (GO:0060428)2.58624519
123negative regulation of cardiac muscle tissue growth (GO:0055022)2.57255448
124negative regulation of heart growth (GO:0061117)2.57255448
125establishment of apical/basal cell polarity (GO:0035089)2.57177662
126surfactant homeostasis (GO:0043129)2.57049669
127smooth muscle tissue development (GO:0048745)2.56822558
128cardiac muscle cell proliferation (GO:0060038)2.56719118
129cardiac muscle cell action potential involved in contraction (GO:0086002)2.56228055
130protein hydroxylation (GO:0018126)2.54894888
131negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.53854195
132cardiac muscle hypertrophy (GO:0003300)2.52262949
133branching involved in salivary gland morphogenesis (GO:0060445)2.50368786
134cornea development in camera-type eye (GO:0061303)2.49506010
135negative regulation of cell size (GO:0045792)2.47986153
136non-canonical Wnt signaling pathway (GO:0035567)2.47819709
137adherens junction organization (GO:0034332)2.47773080
138cell-cell junction assembly (GO:0007043)2.47667796
139regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901212.47429154
140regulation of heart rate by cardiac conduction (GO:0086091)2.47335468
141notochord development (GO:0030903)2.46690870
142vascular endothelial growth factor signaling pathway (GO:0038084)2.45479926
143epithelium development (GO:0060429)2.45089801
144tight junction assembly (GO:0070830)2.44556522
145intermediate filament cytoskeleton organization (GO:0045104)2.44498005
146* cardiac right ventricle morphogenesis (GO:0003215)2.41650101
147negative regulation of axon extension involved in axon guidance (GO:0048843)2.41469068
148pattern specification involved in kidney development (GO:0061004)2.40569337
149phosphatidylserine metabolic process (GO:0006658)2.39602418
150positive regulation of histone deacetylation (GO:0031065)2.38454602
151intermediate filament-based process (GO:0045103)2.37204827
152negative regulation of cartilage development (GO:0061037)2.35762523
153ear development (GO:0043583)2.34993578
154endothelial cell morphogenesis (GO:0001886)2.33832952

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.81862500
2RARG_19884340_ChIP-ChIP_MEFs_Mouse3.20745570
3ZNF263_19887448_ChIP-Seq_K562_Human2.83680234
4PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.59982879
5TRIM28_21343339_ChIP-Seq_HEK293_Human2.58213348
6STAT6_21828071_ChIP-Seq_BEAS2B_Human2.37550819
7ESR2_21235772_ChIP-Seq_MCF-7_Human2.25251109
8SOX9_24532713_ChIP-Seq_HFSC_Mouse2.14901073
9* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.14263506
10* P63_26484246_Chip-Seq_KERATINOCYTES_Human2.12912596
11TP63_17297297_ChIP-ChIP_HaCaT_Human11.3990593
12* ATF3_27146783_Chip-Seq_COLON_Human1.99715729
13RACK7_27058665_Chip-Seq_MCF-7_Human1.99118953
14* HIF1A_21447827_ChIP-Seq_MCF-7_Human1.99004635
15ESR1_21235772_ChIP-Seq_MCF-7_Human1.97646050
16ELK3_25401928_ChIP-Seq_HUVEC_Human1.92504408
17RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.88573050
18TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.87878115
19TBX20_22080862_ChIP-Seq_HEART_Mouse1.83849077
20TBX20_22328084_ChIP-Seq_HEART_Mouse1.83849077
21TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.83833217
22LXR_22292898_ChIP-Seq_THP-1_Human1.82851987
23* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.82691781
24RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.81315937
25* SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.72640795
26* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.71425745
27* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.71425745
28ERG_21242973_ChIP-ChIP_JURKAT_Human1.67232873
29CLOCK_20551151_ChIP-Seq_293T_Human1.59873454
30* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.57662735
31KDM2B_26808549_Chip-Seq_SUP-B15_Human1.57495889
32EP300_21415370_ChIP-Seq_HL-1_Mouse1.57275285
33SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.56385700
34TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.55408641
35RUNX1_27514584_Chip-Seq_MCF-7_Human1.52569948
36FOXO3_23340844_ChIP-Seq_DLD1_Human1.52435702
37CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.52269483
38TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.51284135
39PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.50678842
40* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.48776712
41EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.45929624
42* TP63_22573176_ChIP-Seq_HFKS_Human1.45575195
43TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.44628445
44ZNF217_24962896_ChIP-Seq_MCF-7_Human1.42322402
45ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.39206437
46KDM2B_26808549_Chip-Seq_DND41_Human1.39053415
47UBF1/2_26484160_Chip-Seq_HMECs_Human1.37726371
48ZFP281_18757296_ChIP-ChIP_E14_Mouse1.36098239
49P300_27058665_Chip-Seq_ZR-75-30cells_Human1.35072321
50NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.33764235
51AHR_22903824_ChIP-Seq_MCF-7_Human1.31671694
52KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.29266651
53STAT3_1855785_ChIP-Seq_MESCs_Mouse1.28308557
54CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.24968109
55TP53_22127205_ChIP-Seq_IMR90_Human1.24037968
56CDX2_20551321_ChIP-Seq_CACO-2_Human1.23630845
57ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.23113157
58ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.22887447
59SA1_27219007_Chip-Seq_ERYTHROID_Human1.22674433
60KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.21255608
61TCF7_22412390_ChIP-Seq_EML_Mouse1.20661361
62ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.20618102
63TET1_21490601_ChIP-Seq_MESCs_Mouse1.19358711
64CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.19269439
65KDM2B_26808549_Chip-Seq_K562_Human1.18838357
66TP53_20018659_ChIP-ChIP_R1E_Mouse1.18506084
67PPAR_26484153_Chip-Seq_NCI-H1993_Human1.17136199
68NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.13610033
69CTCF_27219007_Chip-Seq_Bcells_Human1.13159021
70SOX2_20726797_ChIP-Seq_SW620_Human1.12616655
71* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.12146711
72EZH2_27294783_Chip-Seq_ESCs_Mouse1.11357425
73ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.10237036
74P68_20966046_ChIP-Seq_HELA_Human1.10122425
75KLF5_25053715_ChIP-Seq_YYC3_Human1.09464542
76ESR1_20079471_ChIP-ChIP_T-47D_Human1.09432604
77SOX2_27498859_Chip-Seq_STOMACH_Mouse1.09257473
78ESR1_15608294_ChIP-ChIP_MCF-7_Human1.08962543
79ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.07511046
80* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.07234853
81* GATA6_25053715_ChIP-Seq_YYC3_Human1.06986736
82TET1_21451524_ChIP-Seq_MESCs_Mouse1.05791009
83NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.05290333
84DNAJC2_21179169_ChIP-ChIP_NT2_Human1.04203974
85CJUN_26792858_Chip-Seq_BT549_Human1.04101519
86CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.02777239
87HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.01778804
88THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.01011029
89JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.00710313
90* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.00123465
91ELF1_20517297_ChIP-Seq_JURKAT_Human0.99324053
92CREB1_26743006_Chip-Seq_LNCaP_Human0.99321064
93ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.99286881
94RARB_24833708_ChIP-Seq_LIVER_Mouse0.98456645
95SUZ12_27294783_Chip-Seq_ESCs_Mouse0.97903459
96* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.97277337
97JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.97264554
98* GATA4_25053715_ChIP-Seq_YYC3_Human0.95636417
99SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.95325048
100KDM2B_26808549_Chip-Seq_JURKAT_Human0.95264587
101SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.94493554
102FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.94425331
103* TP53_23651856_ChIP-Seq_MEFs_Mouse0.94339513
104POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.93848074
105ZFP281_27345836_Chip-Seq_ESCs_Mouse0.93116208
106SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.91964092
107BCOR_27268052_Chip-Seq_Bcells_Human0.91643296
108SMC1_22415368_ChIP-Seq_MEFs_Mouse0.91003693
109WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.90421611
110TCF3_18692474_ChIP-Seq_MEFs_Mouse0.90067251
111* MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.89032405
112EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.88669092
113PHF8_20622854_ChIP-Seq_HELA_Human0.88291395
114* CTCF_21964334_Chip-Seq_Bcells_Human0.87393441
115PPARA_22158963_ChIP-Seq_LIVER_Mouse0.87328985
116E2F1_20622854_ChIP-Seq_HELA_Human0.87279448
117P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.87106086
118ARNT_22903824_ChIP-Seq_MCF-7_Human0.86612540
119CTCF_20526341_ChIP-Seq_ESCs_Human0.86371790
120BCL6_27268052_Chip-Seq_Bcells_Human0.86162063
121ISL1_27105846_Chip-Seq_CPCs_Mouse0.86006315
122YY1_22570637_ChIP-Seq_MALME-3M_Human0.85981249
123VDR_21846776_ChIP-Seq_THP-1_Human0.85839735
124RNF2_27304074_Chip-Seq_ESCs_Mouse0.85653979
125SMC4_20622854_ChIP-Seq_HELA_Human0.85565088
126SMC3_22415368_ChIP-Seq_MEFs_Mouse0.84556056
127CTCF_27219007_Chip-Seq_ERYTHROID_Human0.84514103
128RAD21_21589869_ChIP-Seq_MESCs_Mouse0.84242658
129SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.83388478
130GATA3_24758297_ChIP-Seq_MCF-7_Human0.82055394

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005275_abnormal_skin_tensile4.36163924
2MP0003705_abnormal_hypodermis_morpholog4.14618301
3MP0000566_synostosis4.07613668
4MP0002796_impaired_skin_barrier4.03523572
5MP0000579_abnormal_nail_morphology3.29922837
6MP0010234_abnormal_vibrissa_follicle3.02086433
7MP0004084_abnormal_cardiac_muscle3.00694314
8MP0002837_dystrophic_cardiac_calcinosis2.81073952
9MP0003566_abnormal_cell_adhesion2.77153423
10MP0005501_abnormal_skin_physiology2.67050597
11MP0000751_myopathy2.54555045
12MP0003941_abnormal_skin_development2.51095594
13MP0002060_abnormal_skin_morphology2.44764840
14MP0000750_abnormal_muscle_regeneration2.34183723
15MP0008438_abnormal_cutaneous_collagen2.27362455
16MP0002098_abnormal_vibrissa_morphology2.16325716
17MP0002234_abnormal_pharynx_morphology2.11407913
18MP0003646_muscle_fatigue2.11148243
19MP0001216_abnormal_epidermal_layer1.95862748
20* MP0005330_cardiomyopathy1.92227305
21MP0000749_muscle_degeneration1.91256963
22MP0000383_abnormal_hair_follicle1.87588702
23MP0003453_abnormal_keratinocyte_physiol1.82970773
24MP0004087_abnormal_muscle_fiber1.82084150
25MP0004036_abnormal_muscle_relaxation1.76546895
26MP0004272_abnormal_basement_membrane1.75026823
27MP0010352_gastrointestinal_tract_polyps1.74720971
28MP0000647_abnormal_sebaceous_gland1.74478604
29MP0004264_abnormal_extraembryonic_tissu1.73980227
30MP0000762_abnormal_tongue_morphology1.73216397
31MP0005409_darkened_coat_color1.73092616
32MP0004215_abnormal_myocardial_fiber1.71162262
33MP0010678_abnormal_skin_adnexa1.70736067
34MP0000467_abnormal_esophagus_morphology1.67871681
35MP0002254_reproductive_system_inflammat1.66651825
36MP0010630_abnormal_cardiac_muscle1.64703164
37MP0010771_integument_phenotype1.63249202
38MP0000377_abnormal_hair_follicle1.59162072
39MP0005623_abnormal_meninges_morphology1.55946695
40MP0003279_aneurysm1.55530275
41MP0008775_abnormal_heart_ventricle1.54378122
42MP0010030_abnormal_orbit_morphology1.49968004
43MP0000013_abnormal_adipose_tissue1.46785102
44MP0003283_abnormal_digestive_organ1.44145604
45MP0004185_abnormal_adipocyte_glucose1.43457762
46MP0005023_abnormal_wound_healing1.43284809
47MP0003878_abnormal_ear_physiology1.42274603
48MP0005377_hearing/vestibular/ear_phenot1.42274603
49* MP0002972_abnormal_cardiac_muscle1.42189148
50MP0005076_abnormal_cell_differentiation1.40533388
51MP0009780_abnormal_chondrocyte_physiolo1.40346222
52MP0003828_pulmonary_edema1.34586734
53MP0001243_abnormal_dermal_layer1.33478120
54MP0000678_abnormal_parathyroid_gland1.32953364
55MP0009053_abnormal_anal_canal1.31561140
56MP0001348_abnormal_lacrimal_gland1.29630518
57MP0001849_ear_inflammation1.29299922
58MP0004947_skin_inflammation1.28857258
59* MP0006138_congestive_heart_failure1.27071191
60* MP0001544_abnormal_cardiovascular_syste1.24825209
61* MP0005385_cardiovascular_system_phenoty1.24825209
62MP0004782_abnormal_surfactant_physiolog1.21038650
63MP0002106_abnormal_muscle_physiology1.20563259
64MP0000733_abnormal_muscle_development1.19099661
65MP0000427_abnormal_hair_cycle1.17696952
66MP0000759_abnormal_skeletal_muscle1.15653579
67MP0000537_abnormal_urethra_morphology1.14645730
68* MP0005620_abnormal_muscle_contractility1.14529926
69MP0002269_muscular_atrophy1.14469836
70MP0005666_abnormal_adipose_tissue1.13259742
71MP0002877_abnormal_melanocyte_morpholog1.12778571
72MP0005451_abnormal_body_composition1.09931935
73MP0009931_abnormal_skin_appearance1.09701982
74MP0003950_abnormal_plasma_membrane1.09252120
75MP0004381_abnormal_hair_follicle1.08986127
76MP0003137_abnormal_impulse_conducting1.07553980
77MP0005503_abnormal_tendon_morphology1.02665251
78MP0005369_muscle_phenotype1.00693407
79MP0005670_abnormal_white_adipose0.98739656
80MP0006054_spinal_hemorrhage0.97219767
81MP0005375_adipose_tissue_phenotype0.95758751
82MP0002282_abnormal_trachea_morphology0.94599300
83MP0004233_abnormal_muscle_weight0.94377259
84MP0004484_altered_response_of0.91602201
85MP0000627_abnormal_mammary_gland0.91528019
86MP0001958_emphysema0.89788642
87MP0005508_abnormal_skeleton_morphology0.87240900
88MP0002127_abnormal_cardiovascular_syste0.85895460
89MP0009384_cardiac_valve_regurgitation0.85551074
90MP0001191_abnormal_skin_condition0.84999559
91MP0000462_abnormal_digestive_system0.84950878
92MP0010368_abnormal_lymphatic_system0.84892987
93MP0000747_muscle_weakness0.84437806
94MP0002089_abnormal_postnatal_growth/wei0.83279176
95MP0001502_abnormal_circadian_rhythm0.82831909
96* MP0000266_abnormal_heart_morphology0.81953707
97MP0004130_abnormal_muscle_cell0.80795915
98MP0003315_abnormal_perineum_morphology0.80089100
99MP0002108_abnormal_muscle_morphology0.77161702
100MP0009379_abnormal_foot_pigmentation0.76451752
101MP0003567_abnormal_fetal_cardiomyocyte0.75362831
102MP0001784_abnormal_fluid_regulation0.75272151
103MP0000538_abnormal_urinary_bladder0.74872470
104MP0003755_abnormal_palate_morphology0.74575371
105MP0002925_abnormal_cardiovascular_devel0.73539939
106MP0004197_abnormal_fetal_growth/weight/0.72314221
107MP0000343_altered_response_to0.72138023
108MP0003221_abnormal_cardiomyocyte_apopto0.71673149
109MP0004858_abnormal_nervous_system0.71261260
110MP0003385_abnormal_body_wall0.70987018
111MP0003011_delayed_dark_adaptation0.70663338
112MP0002249_abnormal_larynx_morphology0.69650736
113* MP0000367_abnormal_coat/_hair0.69184986
114MP0002111_abnormal_tail_morphology0.69111600
115MP0005257_abnormal_intraocular_pressure0.68720294
116MP0000767_abnormal_smooth_muscle0.68447071
117MP0003091_abnormal_cell_migration0.68161538
118MP0008961_abnormal_basal_metabolism0.66655510
119MP0004085_abnormal_heartbeat0.66376409
120MP0003045_fibrosis0.66108206
121MP0000003_abnormal_adipose_tissue0.65225532
122MP0002896_abnormal_bone_mineralization0.64592551
123MP0001299_abnormal_eye_distance/0.64311171
124MP0005083_abnormal_biliary_tract0.61755572
125MP0004043_abnormal_pH_regulation0.60369123
126MP0008875_abnormal_xenobiotic_pharmacok0.59437776
127* MP0001340_abnormal_eyelid_morphology0.58708307
128MP0004885_abnormal_endolymph0.57961109
129MP0004019_abnormal_vitamin_homeostasis0.57932084
130MP0002697_abnormal_eye_size0.57670528
131MP0001879_abnormal_lymphatic_vessel0.57522555
132MP0001881_abnormal_mammary_gland0.57487973
133MP0000534_abnormal_ureter_morphology0.56645275
134MP0000470_abnormal_stomach_morphology0.56272236
135MP0003936_abnormal_reproductive_system0.56141776
136MP0003937_abnormal_limbs/digits/tail_de0.54040997

Predicted human phenotypes

RankGene SetZ-score
1Right ventricular cardiomyopathy (HP:0011663)6.63183116
2Ventricular tachycardia (HP:0004756)5.52558357
3Sudden death (HP:0001699)5.11894514
4Increased connective tissue (HP:0009025)4.83262971
5Hypotrichosis (HP:0001006)4.77295629
6Milia (HP:0001056)4.73789193
7Hyporeflexia of lower limbs (HP:0002600)4.66507188
8Muscle fiber splitting (HP:0003555)4.38955301
9Atrophic scars (HP:0001075)4.37820916
10Onycholysis (HP:0001806)4.12742425
11Woolly hair (HP:0002224)4.05277179
12Fragile nails (HP:0001808)4.03529834
13Plantar hyperkeratosis (HP:0007556)3.84588999
14Pili torti (HP:0003777)3.79570626
15Premature rupture of membranes (HP:0001788)3.76118603
16Fragile skin (HP:0001030)3.60132196
17Protrusio acetabuli (HP:0003179)3.57576441
18Difficulty climbing stairs (HP:0003551)3.35117062
19Distal lower limb muscle weakness (HP:0009053)3.25237788
20Abnormality of nail color (HP:0100643)3.24591130
21Congenital ichthyosiform erythroderma (HP:0007431)3.18456547
22Palmoplantar hyperkeratosis (HP:0000972)3.17053805
23Nail dystrophy (HP:0008404)3.15534029
24Atrial fibrillation (HP:0005110)3.12340713
25Exercise-induced muscle cramps (HP:0003710)3.10850433
26Lipoatrophy (HP:0100578)3.10046532
27Abnormality of the calf musculature (HP:0001430)3.04676465
28Exercise-induced myalgia (HP:0003738)2.98105965
29Type 1 muscle fiber predominance (HP:0003803)2.96684224
30Palmar hyperkeratosis (HP:0010765)2.96451763
31Alopecia of scalp (HP:0002293)2.94063124
32Primary atrial arrhythmia (HP:0001692)2.91687947
33Abnormality of the left ventricular outflow tract (HP:0011103)2.89308537
34Subaortic stenosis (HP:0001682)2.89308537
35Difficulty running (HP:0009046)2.86463481
36Thick nail (HP:0001805)2.85201959
37Supraventricular arrhythmia (HP:0005115)2.83313698
38Supraventricular tachycardia (HP:0004755)2.80869705
39Palmoplantar keratoderma (HP:0000982)2.77046459
40Corneal erosion (HP:0200020)2.76947897
41Calf muscle hypertrophy (HP:0008981)2.75616509
42Natal tooth (HP:0000695)2.72013611
43Erythroderma (HP:0001019)2.70352364
44Mildly elevated creatine phosphokinase (HP:0008180)2.69149571
45Abnormality of the salivary glands (HP:0010286)2.68759403
46Sparse scalp hair (HP:0002209)2.67190021
47Increased IgE level (HP:0003212)2.59660090
48Ventricular fibrillation (HP:0001663)2.59528057
49Distal lower limb amyotrophy (HP:0008944)2.58612507
50Syncope (HP:0001279)2.56863719
51Shallow orbits (HP:0000586)2.56753445
52Ventricular arrhythmia (HP:0004308)2.53695530
53Advanced eruption of teeth (HP:0006288)2.52926162
54Conjunctival hamartoma (HP:0100780)2.52797209
55EMG: myopathic abnormalities (HP:0003458)2.48562087
56Spinal rigidity (HP:0003306)2.47300196
57Abnormal blistering of the skin (HP:0008066)2.44587948
58Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.42353915
59Hypoplasia of dental enamel (HP:0006297)2.41412018
60Dilated cardiomyopathy (HP:0001644)2.36754000
61Cervical subluxation (HP:0003308)2.36559334
62Ankle contracture (HP:0006466)2.35334340
63Myoglobinuria (HP:0002913)2.33836836
64Oligodontia (HP:0000677)2.33110066
65Muscle hypertrophy of the lower extremities (HP:0008968)2.32565053
66Concave nail (HP:0001598)2.28058449
67Amelogenesis imperfecta (HP:0000705)2.27810765
68Asymmetric septal hypertrophy (HP:0001670)2.26969961
69Increased variability in muscle fiber diameter (HP:0003557)2.26857783
70Abnormality of the proximal phalanges of the hand (HP:0009834)2.25136123
71Abnormality of secondary sexual hair (HP:0009888)2.24943745
72Abnormality of the axillary hair (HP:0100134)2.24943745
73Hypoplastic labia majora (HP:0000059)2.24342934
74Neonatal death (HP:0003811)2.23576891
75Anonychia (HP:0001798)2.23130241
76Round ear (HP:0100830)2.21782333
77Ectropion (HP:0000656)2.21538498
78Ridged nail (HP:0001807)2.21356998
79Broad face (HP:0000283)2.19625795
80Areflexia of lower limbs (HP:0002522)2.17797699
81Cerebral aneurysm (HP:0004944)2.17534761
82Absent eyelashes (HP:0000561)2.16930328
83Erythema (HP:0010783)2.15682146
84Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.13713794
85Abnormality of skeletal muscle fiber size (HP:0012084)2.11323120
86Abnormal hair laboratory examination (HP:0003328)2.10212306
87Scapular winging (HP:0003691)2.07434283
88Nasolacrimal duct obstruction (HP:0000579)2.05580188
89Aplasia cutis congenita (HP:0001057)2.05459067
90Palpitations (HP:0001962)2.04917444
91Abnormality of the labia majora (HP:0012881)2.03702208
92Popliteal pterygium (HP:0009756)2.01905384
93Abnormal atrioventricular conduction (HP:0005150)2.01719918
94Abnormality of the neuromuscular junction (HP:0003398)2.01381809
95Fatigable weakness (HP:0003473)2.01381809
96Achilles tendon contracture (HP:0001771)2.00240344
97Acanthosis nigricans (HP:0000956)1.98224214
98Oral leukoplakia (HP:0002745)1.97715202
99Duplicated collecting system (HP:0000081)1.97200626
100Abnormality of the dental root (HP:0006486)1.97165601
101Taurodontia (HP:0000679)1.97165601
102Abnormality of permanent molar morphology (HP:0011071)1.97165601
103Selective tooth agenesis (HP:0001592)1.96889117
104Hamartoma of the eye (HP:0010568)1.96234719
105Curly hair (HP:0002212)1.96210501
106Pterygium (HP:0001059)1.94664901
107Distal upper limb amyotrophy (HP:0007149)1.94603499
108Upper limb amyotrophy (HP:0009129)1.94603499
109Septate vagina (HP:0001153)1.94431058
110Parakeratosis (HP:0001036)1.94335581
111Conical tooth (HP:0000698)1.92934152
112Bundle branch block (HP:0011710)1.92867131
113Laryngomalacia (HP:0001601)1.92096885
114Hyperacusis (HP:0010780)1.91887422
115Abnormality of molar (HP:0011077)1.90573552
116Abnormality of molar morphology (HP:0011070)1.90573552
117Hypoplasia of the uterus (HP:0000013)1.89890550
118Follicular hyperkeratosis (HP:0007502)1.87936007
119Atrioventricular block (HP:0001678)1.87806060
120Peritonitis (HP:0002586)1.87050365
121Trismus (HP:0000211)1.86218477
122Broad metatarsal (HP:0001783)1.85021071
123EMG: neuropathic changes (HP:0003445)1.84834830
124Sparse eyelashes (HP:0000653)1.81739126
125Bronchomalacia (HP:0002780)1.81384698
126Rhabdomyolysis (HP:0003201)1.80816024
127Lip pit (HP:0100267)1.79879012
128Ureteral duplication (HP:0000073)1.79854052
129Bladder diverticulum (HP:0000015)1.79461697
130Neck muscle weakness (HP:0000467)1.78908423
131Aplasia involving bones of the upper limbs (HP:0009823)1.76862077
132Aplasia of the phalanges of the hand (HP:0009802)1.76862077
133Aplasia involving bones of the extremities (HP:0009825)1.76862077
134Abnormality of the Achilles tendon (HP:0005109)1.76650253
135Abnormality of the renal collecting system (HP:0004742)1.75639877
136Hypoplastic ischia (HP:0003175)1.75208130
137Limb-girdle muscle atrophy (HP:0003797)1.74345348
138Abnormality of the dental pulp (HP:0006479)1.73922247
139Flat capital femoral epiphysis (HP:0003370)1.73688941
140Lower limb amyotrophy (HP:0007210)1.73528878
141Hip contracture (HP:0003273)1.72549731
142Genu recurvatum (HP:0002816)1.71259489
143Down-sloping shoulders (HP:0200021)1.70670026
144Heart block (HP:0012722)1.69900156
145Flat acetabular roof (HP:0003180)1.68639073
146Hypohidrosis (HP:0000966)1.67701098
147Focal segmental glomerulosclerosis (HP:0000097)1.66925974
148Brittle hair (HP:0002299)1.65483221
149Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.65313937
150Blepharitis (HP:0000498)1.64476388
151Aplasia/hypoplasia of the femur (HP:0005613)1.62391716
152Breast hypoplasia (HP:0003187)1.61418752
153Short femoral neck (HP:0100864)1.60799617
154Abnormality of the lacrimal duct (HP:0011481)1.59571719
155Testicular atrophy (HP:0000029)1.58939543
156Abnormality of the nasal septum (HP:0000419)1.58666803

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TTN4.48514430
2TRIB34.07208703
3EPHA23.17858261
4PKN23.12246364
5ERN12.75642878
6MAPK152.63147926
7MAPKAPK32.42513551
8EPHB22.38538145
9ICK2.20106855
10PDK42.19544322
11PDK32.19544322
12LATS12.14612472
13DMPK2.07096582
14RIPK12.04532179
15MAP3K32.03590524
16MAP3K62.01933337
17EEF2K1.89309417
18LATS21.88338120
19FER1.73685445
20RPS6KB21.66779067
21MAP3K101.54028604
22WNK41.51850913
23BMX1.50584610
24CDK121.50249870
25PTK61.48786066
26LMTK21.46986299
27MYLK1.45350771
28STK38L1.39138184
29TESK11.32700002
30PDK21.32547534
31TRPM71.31968428
32SIK11.30246738
33MST1R1.29946775
34LRRK21.29676065
35PDGFRA1.29421443
36RPS6KC11.28458642
37RPS6KL11.28458642
38PINK11.27553260
39MAP2K61.27268059
40MTOR1.26469024
41TAOK11.20629716
42SMG11.15353329
43RPS6KA61.15283353
44STK241.14625457
45PTK21.12510792
46OBSCN1.11644824
47NME11.10756115
48PHKG21.09303847
49PHKG11.09303847
50DDR21.09002665
51MET1.07788161
52PRKD21.05290974
53ILK1.05165881
54NTRK11.02405389
55NEK10.98550624
56RPS6KA40.96468697
57MAPK70.96170187
58EPHB10.93902447
59PRKD30.92781832
60PRKD10.89485535
61PAK20.87504784
62PAK30.87201664
63IRAK30.86240067
64PAK40.85104519
65DAPK30.83049588
66STK100.81278083
67STK30.76554092
68STK390.75552287
69DYRK1B0.74402649
70MAP3K110.72841197
71ROCK10.72398176
72PIK3CA0.70891206
73CHUK0.69939956
74MAP3K20.67906394
75PIM20.67516911
76CDC42BPA0.67319507
77BCKDK0.66818726
78FGFR10.66371985
79HIPK20.65360049
80STK380.64893303
81CDK60.64251047
82MAP2K30.61156792
83STK40.60765538
84MAPKAPK50.60251785
85PIK3CG0.58909296
86TGFBR20.57877061
87MAP3K70.56861781
88LIMK10.56302134
89MAP3K90.55624734
90MAPKAPK20.54369149
91AKT20.53599459
92PTK2B0.53112726
93RPS6KA10.52757183
94PRKAA20.51615855
95NEK20.51261287
96MARK20.49617603
97PRKCE0.49379250
98FRK0.48262187
99ADRBK10.48023065
100FGFR40.47984266
101EPHA30.46801581
102PRKAA10.45207933
103MAP2K20.44978845
104CAMK2D0.44585001
105MUSK0.42627310
106ROCK20.40908340
107PRKG20.40893732
108TAOK20.40114025
109FLT30.39379249
110PDGFRB0.39052545
111MAP2K10.38715801
112MAP3K50.37866810
113TGFBR10.37236404
114MAP3K80.36222017
115INSRR0.36139198
116PRKCI0.35076194
117KDR0.33092964
118CDK40.32995304
119MAP3K10.30339792
120CDK70.29811480
121RPS6KA20.29232131
122NME20.28689703
123MAPK80.28434626
124TIE10.28109606
125CAMK2G0.28088004
126ERBB20.27993862
127SIK30.27793501
128MAPK120.26018042
129IRAK10.25583369

Predicted pathways (KEGG)

RankGene SetZ-score
1Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054103.34124254
2Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054123.26105297
3Dilated cardiomyopathy_Homo sapiens_hsa054143.22929512
4Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.03690321
5ECM-receptor interaction_Homo sapiens_hsa045122.87925523
6Basal cell carcinoma_Homo sapiens_hsa052172.70183116
72-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.37606001
8Cardiac muscle contraction_Homo sapiens_hsa042602.32430452
9Adherens junction_Homo sapiens_hsa045202.23246607
10Focal adhesion_Homo sapiens_hsa045102.20127556
11Ovarian steroidogenesis_Homo sapiens_hsa049132.05956101
12Hedgehog signaling pathway_Homo sapiens_hsa043402.02168701
13Proteoglycans in cancer_Homo sapiens_hsa052052.00133203
14Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.97952241
15Hippo signaling pathway_Homo sapiens_hsa043901.97776854
16Ether lipid metabolism_Homo sapiens_hsa005651.92083491
17Amoebiasis_Homo sapiens_hsa051461.84567801
18Small cell lung cancer_Homo sapiens_hsa052221.76281242
19Tight junction_Homo sapiens_hsa045301.74851484
20Sulfur relay system_Homo sapiens_hsa041221.68968744
21Bladder cancer_Homo sapiens_hsa052191.61557538
22Viral myocarditis_Homo sapiens_hsa054161.61547154
23Carbon metabolism_Homo sapiens_hsa012001.60960583
24Phototransduction_Homo sapiens_hsa047441.48133304
25Fatty acid degradation_Homo sapiens_hsa000711.44612191
26Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.43345110
27Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.42865385
28Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.35167449
29Notch signaling pathway_Homo sapiens_hsa043301.32399641
30Central carbon metabolism in cancer_Homo sapiens_hsa052301.30353965
31Insulin resistance_Homo sapiens_hsa049311.27095357
32Adipocytokine signaling pathway_Homo sapiens_hsa049201.25122436
33MicroRNAs in cancer_Homo sapiens_hsa052061.22925589
34Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.22878436
35Protein digestion and absorption_Homo sapiens_hsa049741.19604203
36HIF-1 signaling pathway_Homo sapiens_hsa040661.16188230
37Circadian rhythm_Homo sapiens_hsa047101.15025590
38ABC transporters_Homo sapiens_hsa020101.11473556
39p53 signaling pathway_Homo sapiens_hsa041151.11433272
40AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.10830434
41Leukocyte transendothelial migration_Homo sapiens_hsa046701.10729217
42Glycerophospholipid metabolism_Homo sapiens_hsa005641.09668416
43Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.09317733
44Sphingolipid metabolism_Homo sapiens_hsa006001.09230631
45Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.05672599
46Fatty acid metabolism_Homo sapiens_hsa012121.04608441
47AMPK signaling pathway_Homo sapiens_hsa041521.04148215
48TGF-beta signaling pathway_Homo sapiens_hsa043501.03559288
49Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.03488712
50Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.02590437
51HTLV-I infection_Homo sapiens_hsa051661.00542532
52Wnt signaling pathway_Homo sapiens_hsa043100.99950083
53Toxoplasmosis_Homo sapiens_hsa051450.99216913
54Dorso-ventral axis formation_Homo sapiens_hsa043200.98834671
55Regulation of actin cytoskeleton_Homo sapiens_hsa048100.98434769
56VEGF signaling pathway_Homo sapiens_hsa043700.98292939
57Melanogenesis_Homo sapiens_hsa049160.97825680
58Glucagon signaling pathway_Homo sapiens_hsa049220.97509144
59PPAR signaling pathway_Homo sapiens_hsa033200.97129836
60Propanoate metabolism_Homo sapiens_hsa006400.96982892
61GnRH signaling pathway_Homo sapiens_hsa049120.96046672
62Steroid hormone biosynthesis_Homo sapiens_hsa001400.95995297
63Pathways in cancer_Homo sapiens_hsa052000.92243085
64Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.91607218
65Biosynthesis of amino acids_Homo sapiens_hsa012300.91533488
66Acute myeloid leukemia_Homo sapiens_hsa052210.90800396
67Lysine degradation_Homo sapiens_hsa003100.90729006
68Phenylalanine metabolism_Homo sapiens_hsa003600.89449772
69Histidine metabolism_Homo sapiens_hsa003400.88005026
70Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.86923538
71Thyroid hormone signaling pathway_Homo sapiens_hsa049190.86535407
72Fatty acid biosynthesis_Homo sapiens_hsa000610.84227040
73Insulin signaling pathway_Homo sapiens_hsa049100.81651319
74PI3K-Akt signaling pathway_Homo sapiens_hsa041510.80698074
75Chronic myeloid leukemia_Homo sapiens_hsa052200.80300514
76Fat digestion and absorption_Homo sapiens_hsa049750.78788436
77Arginine biosynthesis_Homo sapiens_hsa002200.78784342
78Longevity regulating pathway - mammal_Homo sapiens_hsa042110.78568268
79Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.77838229
80Nitrogen metabolism_Homo sapiens_hsa009100.77211216
81alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.77119552
82Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.76621042
83Pyruvate metabolism_Homo sapiens_hsa006200.74607135
84Thyroid cancer_Homo sapiens_hsa052160.74560493
85Cyanoamino acid metabolism_Homo sapiens_hsa004600.74027505
86cGMP-PKG signaling pathway_Homo sapiens_hsa040220.72847454
87Linoleic acid metabolism_Homo sapiens_hsa005910.72443674
88Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.71979524
89Glycosaminoglycan degradation_Homo sapiens_hsa005310.71172591
90mTOR signaling pathway_Homo sapiens_hsa041500.70451838
91Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.69983769
92Steroid biosynthesis_Homo sapiens_hsa001000.69872277
93Melanoma_Homo sapiens_hsa052180.68188989
94Renal cell carcinoma_Homo sapiens_hsa052110.67013741
95Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.66922270
96Rap1 signaling pathway_Homo sapiens_hsa040150.66606903
97Endometrial cancer_Homo sapiens_hsa052130.66146317
98Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.64455690
99Platelet activation_Homo sapiens_hsa046110.63178354
100Axon guidance_Homo sapiens_hsa043600.60342370
101Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.60021024
102Arginine and proline metabolism_Homo sapiens_hsa003300.56907462
103Aldosterone synthesis and secretion_Homo sapiens_hsa049250.56659607
104Bile secretion_Homo sapiens_hsa049760.55939964
105Salivary secretion_Homo sapiens_hsa049700.55500214
106Vitamin digestion and absorption_Homo sapiens_hsa049770.53999557
107Tyrosine metabolism_Homo sapiens_hsa003500.53252258
108Ras signaling pathway_Homo sapiens_hsa040140.48389713
109Choline metabolism in cancer_Homo sapiens_hsa052310.47662907
110Renin secretion_Homo sapiens_hsa049240.47127516
111Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.47114129
112Chemical carcinogenesis_Homo sapiens_hsa052040.47054728
113Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.46650572
114Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.46245833
115Galactose metabolism_Homo sapiens_hsa000520.46117708
116Estrogen signaling pathway_Homo sapiens_hsa049150.45979152
117Malaria_Homo sapiens_hsa051440.44892188
118Salmonella infection_Homo sapiens_hsa051320.44085048
119Gastric acid secretion_Homo sapiens_hsa049710.43961503
120Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.43635128
121ErbB signaling pathway_Homo sapiens_hsa040120.42826944
122Parkinsons disease_Homo sapiens_hsa050120.42059603
123Glycerolipid metabolism_Homo sapiens_hsa005610.41702532
124Selenocompound metabolism_Homo sapiens_hsa004500.40581706
125Insulin secretion_Homo sapiens_hsa049110.40347709
126Taste transduction_Homo sapiens_hsa047420.40238557
127Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.39755999
128Apoptosis_Homo sapiens_hsa042100.39668819
129One carbon pool by folate_Homo sapiens_hsa006700.39663809
130Alzheimers disease_Homo sapiens_hsa050100.39208749
131Maturity onset diabetes of the young_Homo sapiens_hsa049500.38221289
132Vascular smooth muscle contraction_Homo sapiens_hsa042700.37361306
133Prostate cancer_Homo sapiens_hsa052150.37316186
134Oxytocin signaling pathway_Homo sapiens_hsa049210.37286373
135Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.36504383
136TNF signaling pathway_Homo sapiens_hsa046680.36240399
137Ribosome_Homo sapiens_hsa030100.35591527
138Huntingtons disease_Homo sapiens_hsa050160.35348745
139Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.30190298
140Fructose and mannose metabolism_Homo sapiens_hsa000510.29978922
141Arachidonic acid metabolism_Homo sapiens_hsa005900.29409212
142Oxidative phosphorylation_Homo sapiens_hsa001900.29235546
143Viral carcinogenesis_Homo sapiens_hsa052030.28624397
144Pancreatic cancer_Homo sapiens_hsa052120.27991752
145Starch and sucrose metabolism_Homo sapiens_hsa005000.26951720
146Fatty acid elongation_Homo sapiens_hsa000620.26408418

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