PPP1R14BP3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit biogenesis (GO:0042274)6.87656212
2maturation of SSU-rRNA (GO:0030490)6.61236091
3viral transcription (GO:0019083)6.51394563
4translational termination (GO:0006415)6.34202765
5ribosomal small subunit assembly (GO:0000028)5.95096798
6SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.70504864
7cotranslational protein targeting to membrane (GO:0006613)5.60597507
8mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.60496539
9protein targeting to ER (GO:0045047)5.59104693
10translational elongation (GO:0006414)5.35615006
11establishment of protein localization to endoplasmic reticulum (GO:0072599)5.34892452
12ribosomal large subunit biogenesis (GO:0042273)5.24228070
13protein localization to endoplasmic reticulum (GO:0070972)5.18201950
14nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)5.15464166
15translational initiation (GO:0006413)5.05300922
16cellular protein complex disassembly (GO:0043624)5.05095252
17viral life cycle (GO:0019058)5.04191629
18energy coupled proton transport, down electrochemical gradient (GO:0015985)4.77737046
19ATP synthesis coupled proton transport (GO:0015986)4.77737046
20establishment of integrated proviral latency (GO:0075713)4.74845797
21chaperone-mediated protein transport (GO:0072321)4.50719548
22translation (GO:0006412)4.48449855
23ribonucleoprotein complex biogenesis (GO:0022613)4.42510258
24protein complex disassembly (GO:0043241)4.38513377
25termination of RNA polymerase III transcription (GO:0006386)4.34792046
26transcription elongation from RNA polymerase III promoter (GO:0006385)4.34792046
27proteasome assembly (GO:0043248)4.29700814
28establishment of protein localization to mitochondrial membrane (GO:0090151)4.25546242
29establishment of viral latency (GO:0019043)4.21594789
30macromolecular complex disassembly (GO:0032984)4.14992068
31spliceosomal snRNP assembly (GO:0000387)4.14827596
32formation of translation preinitiation complex (GO:0001731)4.01160609
33protein targeting to membrane (GO:0006612)3.90581735
34negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.81909218
35respiratory electron transport chain (GO:0022904)3.79620185
36nucleobase-containing small molecule interconversion (GO:0015949)3.76119361
37CENP-A containing nucleosome assembly (GO:0034080)3.75900892
38regulation of mitochondrial translation (GO:0070129)3.75636627
39heterochromatin organization (GO:0070828)3.75525259
40electron transport chain (GO:0022900)3.69810751
41chromatin remodeling at centromere (GO:0031055)3.69619850
42mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.67742485
43negative regulation of ligase activity (GO:0051352)3.66920694
44negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.66920694
45nuclear-transcribed mRNA catabolic process (GO:0000956)3.65640741
46rRNA processing (GO:0006364)3.62919948
47cellular component biogenesis (GO:0044085)3.60291862
48DNA unwinding involved in DNA replication (GO:0006268)3.59692967
49DNA strand elongation involved in DNA replication (GO:0006271)3.56239379
50DNA strand elongation (GO:0022616)3.53382848
51mRNA catabolic process (GO:0006402)3.50245646
52regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.48145415
53rRNA metabolic process (GO:0016072)3.44087372
54positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.41896204
55anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.37089579
56RNA catabolic process (GO:0006401)3.35971971
57ribosome biogenesis (GO:0042254)3.34102327
58mitotic metaphase plate congression (GO:0007080)3.33997207
59protein targeting to mitochondrion (GO:0006626)3.32960792
60pseudouridine synthesis (GO:0001522)3.31195487
61pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.25495024
62mitotic chromosome condensation (GO:0007076)3.23808139
63telomere maintenance via semi-conservative replication (GO:0032201)3.21756075
64establishment of protein localization to mitochondrion (GO:0072655)3.19684038
65protein maturation by protein folding (GO:0022417)3.18487965
66spliceosomal complex assembly (GO:0000245)3.13109078
67IMP biosynthetic process (GO:0006188)3.12093006
68purine nucleobase biosynthetic process (GO:0009113)3.08825224
69ribosome assembly (GO:0042255)3.07790154
70protein localization to mitochondrion (GO:0070585)3.05266301
71DNA replication-independent nucleosome organization (GO:0034724)2.99649866
72DNA replication-independent nucleosome assembly (GO:0006336)2.99649866
73positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.98238839
74guanosine-containing compound biosynthetic process (GO:1901070)2.96003034
757-methylguanosine mRNA capping (GO:0006370)2.95172729
76rRNA modification (GO:0000154)2.95092583
77pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.95014360
78DNA replication checkpoint (GO:0000076)2.94533314
79pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.89798118
80deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.89435056
81protein localization to kinetochore (GO:0034501)2.88077236
82signal transduction involved in DNA damage checkpoint (GO:0072422)2.87094887
83signal transduction involved in DNA integrity checkpoint (GO:0072401)2.87094887
84UTP biosynthetic process (GO:0006228)2.86955933
85RNA capping (GO:0036260)2.86445112
867-methylguanosine RNA capping (GO:0009452)2.86445112
87transcription from RNA polymerase I promoter (GO:0006360)2.86309084
88regulation of ubiquitin-protein transferase activity (GO:0051438)2.84947293
89transcription-coupled nucleotide-excision repair (GO:0006283)2.84657612
90regulation of cellular amino acid metabolic process (GO:0006521)2.84492935
91DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.84442176
92mitotic sister chromatid segregation (GO:0000070)2.84088289
93positive regulation of viral transcription (GO:0050434)2.83582619
94cullin deneddylation (GO:0010388)2.83107070
95signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.82387848
96intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.82387848
97histone exchange (GO:0043486)2.82373651
98positive regulation of ligase activity (GO:0051351)2.82349567
99signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.81991234
100signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.81991234

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.71038222
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.69431760
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.16461386
4HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.66011079
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.57908424
6MYC_19079543_ChIP-ChIP_MESCs_Mouse3.22112822
7GABP_17652178_ChIP-ChIP_JURKAT_Human3.17314647
8MYC_18358816_ChIP-ChIP_MESCs_Mouse3.11786418
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.07429686
10EST1_17652178_ChIP-ChIP_JURKAT_Human3.03057597
11CREB1_15753290_ChIP-ChIP_HEK293T_Human3.02017724
12FOXM1_23109430_ChIP-Seq_U2OS_Human2.94895081
13MYC_19030024_ChIP-ChIP_MESCs_Mouse2.94202394
14TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.93211360
15ETS1_20019798_ChIP-Seq_JURKAT_Human2.89483947
16FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.82132034
17XRN2_22483619_ChIP-Seq_HELA_Human2.62125038
18CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.60319945
19E2F4_17652178_ChIP-ChIP_JURKAT_Human2.51694796
20THAP11_20581084_ChIP-Seq_MESCs_Mouse2.51348613
21E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.38102469
22DCP1A_22483619_ChIP-Seq_HELA_Human2.36050945
23SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.35129486
24NELFA_20434984_ChIP-Seq_ESCs_Mouse2.24915230
25E2F1_18555785_ChIP-Seq_MESCs_Mouse2.18230872
26MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.17964221
27TTF2_22483619_ChIP-Seq_HELA_Human2.14926010
28NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.12140662
29YY1_21170310_ChIP-Seq_MESCs_Mouse1.83888262
30POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.83746914
31GABP_19822575_ChIP-Seq_HepG2_Human1.81856941
32NANOG_18555785_ChIP-Seq_MESCs_Mouse1.79865204
33ELK1_19687146_ChIP-ChIP_HELA_Human1.79839200
34AR_21909140_ChIP-Seq_LNCAP_Human1.78773428
35MYCN_18555785_ChIP-Seq_MESCs_Mouse1.74753352
36ELF1_17652178_ChIP-ChIP_JURKAT_Human1.72972927
37DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.72229147
38ZFX_18555785_ChIP-Seq_MESCs_Mouse1.71427651
39E2F1_21310950_ChIP-Seq_MCF-7_Human1.71360234
40FOXP3_21729870_ChIP-Seq_TREG_Human1.70047995
41TP63_17297297_ChIP-ChIP_HaCaT_Human1.67667404
42CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.65419658
43CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.63805704
44TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.63309519
45HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.63250648
46MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.63030504
47ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.61396082
48ZNF263_19887448_ChIP-Seq_K562_Human1.60348729
49PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.58669489
50VDR_23849224_ChIP-Seq_CD4+_Human1.54195671
51YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.46657690
52SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.40139365
53FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.39468663
54KLF4_18555785_ChIP-Seq_MESCs_Mouse1.37900010
55MYC_22102868_ChIP-Seq_BL_Human1.32721016
56HOXB4_20404135_ChIP-ChIP_EML_Mouse1.30656999
57SRF_21415370_ChIP-Seq_HL-1_Mouse1.30248981
58MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.29959716
59ERG_20887958_ChIP-Seq_HPC-7_Mouse1.28685459
60POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.26058835
61KDM5A_27292631_Chip-Seq_BREAST_Human1.23829936
62SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.22320931
63POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.20862629
64ELK1_22589737_ChIP-Seq_MCF10A_Human1.20047739
65ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.18785128
66CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.18549325
67FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.17096019
68STAT3_1855785_ChIP-Seq_MESCs_Mouse1.16531471
69PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.14547907
70E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.13951907
71SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.13902543
72KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.13255868
73VDR_21846776_ChIP-Seq_THP-1_Human1.12228641
74TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.11159592
75SOX2_18555785_ChIP-Seq_MESCs_Mouse1.09288914
76TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.07522032
77CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.06516070
78KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.05641275
79CTCF_18555785_ChIP-Seq_MESCs_Mouse1.04868961
80OCT4_18692474_ChIP-Seq_MEFs_Mouse1.03469043
81PADI4_21655091_ChIP-ChIP_MCF-7_Human0.99232934
82ATF3_27146783_Chip-Seq_COLON_Human0.98443311
83GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.98232456
84ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.98016598
85SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.97568428
86CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.97214027
87BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.96588828
88DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.96422634
89CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.93749913
90CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.93200933
91ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.93096406
92CHD1_26751641_Chip-Seq_LNCaP_Human0.91442158
93HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.90678019
94ELK3_25401928_ChIP-Seq_HUVEC_Human0.89876348
95SOX2_18692474_ChIP-Seq_MEFs_Mouse0.89684387
96ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.89597248
97SOX17_20123909_ChIP-Seq_XEN_Mouse0.88998941
98SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.88345298
99MYC_18940864_ChIP-ChIP_HL60_Human0.88328537
100CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.85865544

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation5.45022941
2MP0003693_abnormal_embryo_hatching3.91150344
3MP0004957_abnormal_blastocyst_morpholog3.79061964
4MP0003705_abnormal_hypodermis_morpholog3.19508385
5MP0010094_abnormal_chromosome_stability3.11956817
6MP0008007_abnormal_cellular_replicative3.09905452
7MP0003111_abnormal_nucleus_morphology2.95478789
8MP0003941_abnormal_skin_development2.93777145
9MP0008058_abnormal_DNA_repair2.72389009
10MP0003077_abnormal_cell_cycle2.67320848
11MP0002877_abnormal_melanocyte_morpholog2.57895457
12MP0003806_abnormal_nucleotide_metabolis2.47623802
13MP0008932_abnormal_embryonic_tissue2.44472154
14MP0003123_paternal_imprinting2.36801988
15MP0009053_abnormal_anal_canal2.34599922
16MP0000350_abnormal_cell_proliferation2.10637721
17MP0006292_abnormal_olfactory_placode1.95247323
18MP0001188_hyperpigmentation1.94264161
19MP0003186_abnormal_redox_activity1.93113100
20MP0002822_catalepsy1.91360127
21MP0003786_premature_aging1.88307444
22MP0000537_abnormal_urethra_morphology1.87757785
23MP0003315_abnormal_perineum_morphology1.84696154
24MP0005451_abnormal_body_composition1.82475171
25MP0002796_impaired_skin_barrier1.65651438
26MP0005501_abnormal_skin_physiology1.64466853
27MP0001730_embryonic_growth_arrest1.63772917
28MP0010352_gastrointestinal_tract_polyps1.58293845
29MP0002277_abnormal_respiratory_mucosa1.58150121
30MP0003566_abnormal_cell_adhesion1.55523823
31MP0010030_abnormal_orbit_morphology1.54034938
32MP0008438_abnormal_cutaneous_collagen1.49518491
33MP0002060_abnormal_skin_morphology1.45434399
34MP0006035_abnormal_mitochondrial_morpho1.36808233
35MP0000750_abnormal_muscle_regeneration1.34137254
36MP0003453_abnormal_keratinocyte_physiol1.33589646
37MP0000467_abnormal_esophagus_morphology1.32575998
38MP0003890_abnormal_embryonic-extraembry1.30299790
39MP0004233_abnormal_muscle_weight1.29449861
40MP0001672_abnormal_embryogenesis/_devel1.26290102
41MP0005380_embryogenesis_phenotype1.26290102
42MP0005257_abnormal_intraocular_pressure1.26180217
43MP0000358_abnormal_cell_content/1.25600315
44MP0003950_abnormal_plasma_membrane1.25499841
45MP0000313_abnormal_cell_death1.24964552
46MP0000762_abnormal_tongue_morphology1.24725104
47MP0002080_prenatal_lethality1.23400694
48MP0001293_anophthalmia1.23080099
49MP0000490_abnormal_crypts_of1.22674461
50MP0002085_abnormal_embryonic_tissue1.21636306
51MP0000579_abnormal_nail_morphology1.18658748
52MP0001697_abnormal_embryo_size1.17609144
53MP0009672_abnormal_birth_weight1.15153763
54MP0008057_abnormal_DNA_replication1.10090664
55MP0000343_altered_response_to1.10049471
56MP0003984_embryonic_growth_retardation1.09059478
57MP0009333_abnormal_splenocyte_physiolog1.09022352
58MP0001542_abnormal_bone_strength1.07245897
59MP0001286_abnormal_eye_development1.05482309
60MP0005084_abnormal_gallbladder_morpholo1.05307828
61MP0002697_abnormal_eye_size1.03440544
62MP0002088_abnormal_embryonic_growth/wei1.02015939
63MP0002111_abnormal_tail_morphology1.00039581
64MP0000858_altered_metastatic_potential0.98959758
65MP0003718_maternal_effect0.98661672
66MP0001216_abnormal_epidermal_layer0.97711380
67MP0001529_abnormal_vocalization0.97274985
68MP0006072_abnormal_retinal_apoptosis0.96784557
69MP0009250_abnormal_appendicular_skeleto0.94674147
70MP0001727_abnormal_embryo_implantation0.91619266
71MP0002653_abnormal_ependyma_morphology0.91226263
72MP0005623_abnormal_meninges_morphology0.90835464
73MP0006036_abnormal_mitochondrial_physio0.88172313
74MP0003942_abnormal_urinary_system0.87617549
75MP0002084_abnormal_developmental_patter0.85467058
76MP0004185_abnormal_adipocyte_glucose0.82758026
77MP0003191_abnormal_cellular_cholesterol0.82733914
78MP0010771_integument_phenotype0.82069979
79MP0000749_muscle_degeneration0.79839375
80MP0002163_abnormal_gland_morphology0.77985853
81MP0002019_abnormal_tumor_incidence0.76811369
82MP0005197_abnormal_uvea_morphology0.76442213
83MP0005023_abnormal_wound_healing0.76380732
84MP0001853_heart_inflammation0.75586981
85MP0010307_abnormal_tumor_latency0.73849203
86MP0005384_cellular_phenotype0.73311353
87MP0001186_pigmentation_phenotype0.72149805
88MP0002177_abnormal_outer_ear0.70423425
89MP0002006_tumorigenesis0.70230751
90MP0004272_abnormal_basement_membrane0.69185783
91MP0000534_abnormal_ureter_morphology0.69151802
92MP0004510_myositis0.68983585
93MP0004197_abnormal_fetal_growth/weight/0.68312775
94MP0001243_abnormal_dermal_layer0.67845155
95MP0002254_reproductive_system_inflammat0.64047114
96MP0002086_abnormal_extraembryonic_tissu0.63389548
97MP0005621_abnormal_cell_physiology0.63332935
98MP0003937_abnormal_limbs/digits/tail_de0.63237760
99MP0000733_abnormal_muscle_development0.62727478
100MP0001881_abnormal_mammary_gland0.61787662

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)4.77934359
2Macrocytic anemia (HP:0001972)4.70962978
3Acute necrotizing encephalopathy (HP:0006965)4.56233204
4Reticulocytopenia (HP:0001896)4.51640293
5Abnormal number of erythroid precursors (HP:0012131)4.44146428
6Abnormal mitochondria in muscle tissue (HP:0008316)4.34635798
7Increased hepatocellular lipid droplets (HP:0006565)4.13653152
8Selective tooth agenesis (HP:0001592)3.98412925
9Aplastic anemia (HP:0001915)3.97287753
10Acute encephalopathy (HP:0006846)3.80887610
11Decreased activity of mitochondrial respiratory chain (HP:0008972)3.75456667
12Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.75456667
13Abnormal number of incisors (HP:0011064)3.62328349
14Progressive macrocephaly (HP:0004481)3.54835301
15Pallor (HP:0000980)3.54289800
16Mitochondrial inheritance (HP:0001427)3.49115241
17Lipid accumulation in hepatocytes (HP:0006561)3.44165379
18Microretrognathia (HP:0000308)3.37903820
19Renal Fanconi syndrome (HP:0001994)3.37587025
20Rough bone trabeculation (HP:0100670)3.28716176
21Aplasia/Hypoplasia of the sacrum (HP:0008517)3.26145455
22Increased intramyocellular lipid droplets (HP:0012240)3.19650296
23Testicular atrophy (HP:0000029)3.18960676
24Respiratory difficulties (HP:0002880)3.08666434
25Trismus (HP:0000211)3.04480897
26Oral leukoplakia (HP:0002745)3.04008706
27Increased CSF lactate (HP:0002490)3.01508292
28Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.85099484
29Multiple enchondromatosis (HP:0005701)2.82567915
30Exertional dyspnea (HP:0002875)2.79279262
31Cerebral edema (HP:0002181)2.71272819
32Sparse eyelashes (HP:0000653)2.67815975
33Progressive muscle weakness (HP:0003323)2.66387292
34Ankle contracture (HP:0006466)2.60056254
35Abnormal trabecular bone morphology (HP:0100671)2.59103504
36Hepatocellular necrosis (HP:0001404)2.56986907
37Increased muscle lipid content (HP:0009058)2.52685542
38Exercise intolerance (HP:0003546)2.51438880
39Nasolacrimal duct obstruction (HP:0000579)2.50642287
40Achilles tendon contracture (HP:0001771)2.45170057
41Premature rupture of membranes (HP:0001788)2.44226148
42Pancytopenia (HP:0001876)2.43687547
43Redundant skin (HP:0001582)2.40593368
44Congenital, generalized hypertrichosis (HP:0004540)2.34569784
45Hepatic necrosis (HP:0002605)2.27005000
46Deviation of the thumb (HP:0009603)2.26865631
47Reduced subcutaneous adipose tissue (HP:0003758)2.24752626
48Cleft eyelid (HP:0000625)2.23717961
49Abnormality of placental membranes (HP:0011409)2.23363666
50Amniotic constriction ring (HP:0009775)2.23363666
51Spastic diplegia (HP:0001264)2.22039799
52Partial duplication of thumb phalanx (HP:0009944)2.11558141
53Breast hypoplasia (HP:0003187)2.09951635
54Facial cleft (HP:0002006)2.05095346
55Megaloblastic anemia (HP:0001889)2.04481677
56Respiratory failure (HP:0002878)2.04396749
57Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.00315422
58Abnormal hemoglobin (HP:0011902)1.98656647
59Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.95822165
60Abnormality of the lacrimal duct (HP:0011481)1.95146533
61Increased serum lactate (HP:0002151)1.95007352
62Chromosomal breakage induced by crosslinking agents (HP:0003221)1.94916328
63Fragile skin (HP:0001030)1.93521751
6411 pairs of ribs (HP:0000878)1.93220753
65Abnormality of the Achilles tendon (HP:0005109)1.91827863
66Fragile nails (HP:0001808)1.91414719
67Partial duplication of the phalanx of hand (HP:0009999)1.90574579
68Lactic acidosis (HP:0003128)1.90338857
69Microvesicular hepatic steatosis (HP:0001414)1.88936872
70Onycholysis (HP:0001806)1.88651961
71Leukodystrophy (HP:0002415)1.88474104
72Reduced antithrombin III activity (HP:0001976)1.87608756
73Secondary amenorrhea (HP:0000869)1.86175646
74Birth length less than 3rd percentile (HP:0003561)1.83545571
75Glossoptosis (HP:0000162)1.83315926
76Proximal placement of thumb (HP:0009623)1.82980622
77Premature skin wrinkling (HP:0100678)1.80530102
78Short nail (HP:0001799)1.79815671
79Tracheoesophageal fistula (HP:0002575)1.78865822
80Elbow flexion contracture (HP:0002987)1.78218458
81Microglossia (HP:0000171)1.76471766
82Abnormality of the anterior horn cell (HP:0006802)1.74493461
83Degeneration of anterior horn cells (HP:0002398)1.74493461
84Delayed cranial suture closure (HP:0000270)1.74255568
85Atrophic scars (HP:0001075)1.73070687
86Aplasia/Hypoplasia of the uvula (HP:0010293)1.73006771
87Abnormalities of placenta or umbilical cord (HP:0001194)1.72484896
88Septo-optic dysplasia (HP:0100842)1.71155087
89Abnormality of the preputium (HP:0100587)1.70631056
90Increased connective tissue (HP:0009025)1.68918356
91Increased serum pyruvate (HP:0003542)1.68727942
92Abnormality of glycolysis (HP:0004366)1.68209749
93Nail dystrophy (HP:0008404)1.67483401
94Upper limb muscle weakness (HP:0003484)1.65984788
95Vertebral compression fractures (HP:0002953)1.65447858
96Milia (HP:0001056)1.65115314
97Hyperacusis (HP:0010780)1.65089566
98Generalized amyotrophy (HP:0003700)1.64356667
99Missing ribs (HP:0000921)1.64089799
100Abnormality of the umbilical cord (HP:0010881)1.63709782

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NME25.84915140
2VRK24.65641092
3IRAK33.75311346
4BUB13.74043101
5CDC73.49417417
6EPHA22.50934080
7PBK2.40604336
8SMG12.22187497
9TTK2.18036460
10STK162.15776908
11SRPK11.88526402
12TSSK61.85662922
13NEK11.81325382
14PAK41.75862610
15TESK21.59914209
16NME11.59693354
17MAP3K101.53422894
18TESK11.51870937
19TAOK21.48718039
20ERBB41.46550183
21LIMK11.44946914
22ILK1.42508255
23CHEK21.40506349
24TAF11.37152047
25ARAF1.35693460
26SCYL21.34779585
27NEK21.31113246
28TRIB31.28896424
29LRRK21.28410085
30PLK11.28203456
31PLK31.27365853
32MAP3K81.24120050
33LATS21.18118230
34VRK11.17885003
35EIF2AK11.13610121
36PLK41.11522802
37AURKA1.10747403
38AURKB1.10746832
39STK41.08588099
40MST1R1.05156297
41ABL21.03770040
42MAP3K121.02800951
43MOS1.01664197
44MST41.00093403
45CDK70.99381075
46WEE10.92903775
47BRAF0.92664196
48STK100.89279575
49DYRK30.87321334
50SIK10.82042648
51CDK80.79979282
52ICK0.78532904
53TNIK0.77842525
54PTK20.73524022
55LMTK20.73365786
56EPHB20.73273347
57BRSK20.71242343
58CDK40.71054690
59PIM20.70482092
60BRSK10.68792898
61PRPF4B0.67256625
62CHEK10.66757574
63RPS6KA40.65720821
64EIF2AK20.64448356
65PNCK0.63758024
66PTK60.63502274
67EIF2AK30.63088661
68PAK10.62966632
69ATR0.62450981
70CSNK2A20.61362934
71DMPK0.61215261
72DYRK20.60840943
73TTN0.60125213
74DAPK10.60096971
75MAP3K110.58490969
76IRAK20.58432966
77CLK10.54731540
78MAP2K30.53781375
79CDK190.50821749
80CSNK2A10.48338415
81ZAK0.46339947
82PRKCI0.45351163
83BCKDK0.43342170
84CDK11A0.42794127
85RPS6KB20.42650705
86PAK20.42218571
87ERN10.40377324
88PDK20.40282843
89MET0.40085947
90CDK150.38653563
91PASK0.37974822
92MYLK0.37326680
93CDK180.35566795
94CDK140.34631101
95IRAK40.33387470
96TLK10.32993488
97IKBKB0.30193086
98CHUK0.28444555
99DAPK30.28389447
100MKNK10.27223438

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030106.05912059
2Proteasome_Homo sapiens_hsa030504.32261357
3DNA replication_Homo sapiens_hsa030303.79507842
4Oxidative phosphorylation_Homo sapiens_hsa001903.51695783
5RNA polymerase_Homo sapiens_hsa030203.46866330
6Parkinsons disease_Homo sapiens_hsa050123.18200549
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.97387059
8Spliceosome_Homo sapiens_hsa030402.84120916
9Mismatch repair_Homo sapiens_hsa034302.66511142
10Huntingtons disease_Homo sapiens_hsa050162.43247283
11Base excision repair_Homo sapiens_hsa034102.38274367
12Pyrimidine metabolism_Homo sapiens_hsa002402.32758893
13Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.15917551
14Alzheimers disease_Homo sapiens_hsa050102.09520263
15RNA transport_Homo sapiens_hsa030132.05401215
16Protein export_Homo sapiens_hsa030602.01363718
17One carbon pool by folate_Homo sapiens_hsa006701.96890766
18Nucleotide excision repair_Homo sapiens_hsa034201.92652675
19Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.89215895
20Homologous recombination_Homo sapiens_hsa034401.80753204
21Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.78212087
22Cell cycle_Homo sapiens_hsa041101.64012419
23Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.64007635
24Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.31225223
25Cardiac muscle contraction_Homo sapiens_hsa042601.29282939
26Pyruvate metabolism_Homo sapiens_hsa006201.24604187
27RNA degradation_Homo sapiens_hsa030181.22388154
28Basal transcription factors_Homo sapiens_hsa030221.22350323
29Purine metabolism_Homo sapiens_hsa002301.14584107
30Vitamin B6 metabolism_Homo sapiens_hsa007501.13440348
31Fanconi anemia pathway_Homo sapiens_hsa034601.13041099
32Bladder cancer_Homo sapiens_hsa052191.08780317
33Folate biosynthesis_Homo sapiens_hsa007901.06447887
34Epstein-Barr virus infection_Homo sapiens_hsa051691.00754145
35mRNA surveillance pathway_Homo sapiens_hsa030150.99209390
36Non-homologous end-joining_Homo sapiens_hsa034500.98438704
37Biosynthesis of amino acids_Homo sapiens_hsa012300.95112148
38Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.91141320
39Sulfur relay system_Homo sapiens_hsa041220.87284657
40Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.85955846
41Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.82682928
42Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.82574173
43Cysteine and methionine metabolism_Homo sapiens_hsa002700.77042589
44Shigellosis_Homo sapiens_hsa051310.74488347
45Carbon metabolism_Homo sapiens_hsa012000.74470386
46Selenocompound metabolism_Homo sapiens_hsa004500.74449148
47Thyroid cancer_Homo sapiens_hsa052160.70791707
48Glutathione metabolism_Homo sapiens_hsa004800.70009801
49p53 signaling pathway_Homo sapiens_hsa041150.68433579
50Pentose phosphate pathway_Homo sapiens_hsa000300.66725606
51Vibrio cholerae infection_Homo sapiens_hsa051100.64644587
52N-Glycan biosynthesis_Homo sapiens_hsa005100.63077120
53Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.58035279
54Small cell lung cancer_Homo sapiens_hsa052220.56421067
55Basal cell carcinoma_Homo sapiens_hsa052170.54448766
56Sulfur metabolism_Homo sapiens_hsa009200.54362456
57Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.51836737
58Central carbon metabolism in cancer_Homo sapiens_hsa052300.51742412
59Fatty acid elongation_Homo sapiens_hsa000620.50252647
602-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.49239304
61Metabolic pathways_Homo sapiens_hsa011000.48316985
62Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.46596117
63Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.45759545
64HTLV-I infection_Homo sapiens_hsa051660.41160939
65Galactose metabolism_Homo sapiens_hsa000520.37435369
66Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.33707182
67Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.32516370
68Apoptosis_Homo sapiens_hsa042100.32440802
69Viral carcinogenesis_Homo sapiens_hsa052030.31511767
70Prion diseases_Homo sapiens_hsa050200.31341519
71Hippo signaling pathway_Homo sapiens_hsa043900.31135230
72Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.29910163
73Fructose and mannose metabolism_Homo sapiens_hsa000510.28757480
74Oocyte meiosis_Homo sapiens_hsa041140.28479658
75Hedgehog signaling pathway_Homo sapiens_hsa043400.26707004
76Salmonella infection_Homo sapiens_hsa051320.25401842
77Melanoma_Homo sapiens_hsa052180.24235571
78TGF-beta signaling pathway_Homo sapiens_hsa043500.23709984
79Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.22859665
80Chronic myeloid leukemia_Homo sapiens_hsa052200.21729560
81Wnt signaling pathway_Homo sapiens_hsa043100.19732853
82Proteoglycans in cancer_Homo sapiens_hsa052050.19092355
83Steroid biosynthesis_Homo sapiens_hsa001000.17551043
84Prostate cancer_Homo sapiens_hsa052150.16849861
85Renal cell carcinoma_Homo sapiens_hsa052110.16716757
86MicroRNAs in cancer_Homo sapiens_hsa052060.15995762
87Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.14083721
88Pathways in cancer_Homo sapiens_hsa052000.13739809
89Herpes simplex infection_Homo sapiens_hsa051680.11966233
90Regulation of actin cytoskeleton_Homo sapiens_hsa048100.11905289
91Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.10128254
92Drug metabolism - other enzymes_Homo sapiens_hsa009830.10050640
93Legionellosis_Homo sapiens_hsa051340.09836948
94Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.09406520
95Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.09377623
96Vitamin digestion and absorption_Homo sapiens_hsa049770.08840914
97Hepatitis B_Homo sapiens_hsa051610.07877873
98Pancreatic cancer_Homo sapiens_hsa052120.07075209
99Non-small cell lung cancer_Homo sapiens_hsa052230.06912509
100RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.04858834

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