PPP1R14C

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The degree of protein phosphorylation is regulated by a balance of protein kinase and phosphatase activities. Protein phosphatase-1 (PP1; see MIM 176875) is a signal-transducing phosphatase that influences neuronal activity, protein synthesis, metabolism, muscle contraction, and cell division. PPP1R14C is an inhibitor of PP1 (Liu et al., 2002 [PubMed 11812771]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of potassium ion transmembrane transporter activity (GO:1901017)7.09315568
2cardiac myofibril assembly (GO:0055003)6.98650616
3sarcomere organization (GO:0045214)6.69463277
4negative regulation of potassium ion transmembrane transport (GO:1901380)6.39036746
5regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO6.20335094
6positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)6.15796649
7myofibril assembly (GO:0030239)6.11270185
8regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)6.11053318
9axonemal dynein complex assembly (GO:0070286)5.84340818
10actin-myosin filament sliding (GO:0033275)5.73410883
11muscle filament sliding (GO:0030049)5.73410883
12regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)5.65921161
13cardiac muscle contraction (GO:0060048)5.42719041
14epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)5.37058820
15ventricular cardiac muscle cell action potential (GO:0086005)5.27684010
16regulation of sarcomere organization (GO:0060297)5.14359506
17cardiac muscle cell development (GO:0055013)5.06818405
18regulation of cell communication by electrical coupling (GO:0010649)5.01281935
19regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)4.97519221
20regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)4.93344220
21cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.90598440
22cilium movement (GO:0003341)4.90260523
23regulation of actin filament-based movement (GO:1903115)4.87896800
24actin-mediated cell contraction (GO:0070252)4.82640240
25cell communication involved in cardiac conduction (GO:0086065)4.81725733
26cardiac cell development (GO:0055006)4.77546968
27plasma membrane repair (GO:0001778)4.72116074
28regulation of relaxation of muscle (GO:1901077)4.69650575
29regulation of membrane repolarization (GO:0060306)4.65357812
30regulation of skeletal muscle contraction (GO:0014819)4.64645024
31epithelial cilium movement (GO:0003351)4.64486908
32cardiac muscle hypertrophy (GO:0003300)4.63866965
33sarcoplasmic reticulum calcium ion transport (GO:0070296)4.59869825
34keratinocyte development (GO:0003334)4.56706666
35bundle of His cell to Purkinje myocyte communication (GO:0086069)4.55158923
36cardiac muscle tissue morphogenesis (GO:0055008)4.54342073
37actomyosin structure organization (GO:0031032)4.53024471
38tricarboxylic acid cycle (GO:0006099)4.48861715
39cell communication by electrical coupling (GO:0010644)4.48592130
40cilium or flagellum-dependent cell motility (GO:0001539)4.44882304
41striated muscle contraction (GO:0006941)4.44771659
42striated muscle hypertrophy (GO:0014897)4.41133102
43ventricular cardiac muscle tissue morphogenesis (GO:0055010)4.36715889
44adult heart development (GO:0007512)4.36681020
45heart trabecula formation (GO:0060347)4.26904956
46regulation of striated muscle contraction (GO:0006942)4.24967190
47muscle tissue morphogenesis (GO:0060415)4.11350836
48regulation of cardioblast differentiation (GO:0051890)4.08783733
49negative regulation of neurotransmitter transport (GO:0051589)3.99285078
50establishment of skin barrier (GO:0061436)3.92297890
51mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.91154507
52regulation of the force of heart contraction (GO:0002026)3.90623440
53motile cilium assembly (GO:0044458)3.88752501
54lateral sprouting from an epithelium (GO:0060601)3.87085713
55regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.86522404
56cardiac muscle cell action potential involved in contraction (GO:0086002)3.86271461
57cardiac muscle cell action potential (GO:0086001)3.85700244
58cardiac conduction (GO:0061337)3.85188330
59carnitine shuttle (GO:0006853)3.85095600
60muscle hypertrophy (GO:0014896)3.80450341
61regulation of acyl-CoA biosynthetic process (GO:0050812)3.79814570
62establishment of tissue polarity (GO:0007164)3.76152839
63establishment of planar polarity (GO:0001736)3.76152839
64relaxation of cardiac muscle (GO:0055119)3.74983595
65membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.74722403
66hemidesmosome assembly (GO:0031581)3.74612017
67actin filament-based movement (GO:0030048)3.73062959
68ATP synthesis coupled proton transport (GO:0015986)3.71448936
69energy coupled proton transport, down electrochemical gradient (GO:0015985)3.71448936
70positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.70878756
71regulation of cardiac muscle contraction (GO:0055117)3.70281301
72regulation of heart rate by cardiac conduction (GO:0086091)3.69445274
73desmosome organization (GO:0002934)3.67888617
74regulation of heart rate (GO:0002027)3.67648518
75cardiac muscle adaptation (GO:0014887)3.65323970
76cardiac muscle hypertrophy in response to stress (GO:0014898)3.65323970
77muscle hypertrophy in response to stress (GO:0003299)3.65323970
78regulation of water loss via skin (GO:0033561)3.64415290
79chemical homeostasis within a tissue (GO:0048875)3.64021032
80negative regulation of protein localization to cell surface (GO:2000009)3.60997742
81axoneme assembly (GO:0035082)3.59238868
82negative regulation of potassium ion transport (GO:0043267)3.57383097
83detection of calcium ion (GO:0005513)3.56676421
84positive regulation of cell size (GO:0045793)3.56257966
85heart contraction (GO:0060047)3.53521910
86heart process (GO:0003015)3.53521910
87negative regulation of cardiac muscle cell apoptotic process (GO:0010667)3.51822233
88positive regulation of potassium ion transmembrane transport (GO:1901381)3.49422612
89regulation of cardiac muscle cell contraction (GO:0086004)3.49314227
90membrane repolarization during action potential (GO:0086011)3.49247623
91regulation of cardioblast proliferation (GO:0003264)3.48340316
92regulation of secondary heart field cardioblast proliferation (GO:0003266)3.48340316
93surfactant homeostasis (GO:0043129)3.47450891
94regulation of cofactor metabolic process (GO:0051193)3.42997682
95regulation of coenzyme metabolic process (GO:0051196)3.42997682
96left/right pattern formation (GO:0060972)3.41519593
97keratinization (GO:0031424)3.41071316
98cardiac chamber formation (GO:0003207)3.35975753
99regulation of calcium ion transmembrane transport (GO:1903169)3.33098569
100regulation of calcium ion transmembrane transporter activity (GO:1901019)3.33098569
101fatty acid transmembrane transport (GO:1902001)3.32853785
102regulation of potassium ion transmembrane transporter activity (GO:1901016)3.32490548
103regulation of heart contraction (GO:0008016)3.27976387
104negative regulation of neurotransmitter secretion (GO:0046929)3.25888920
105negative regulation of striated muscle cell apoptotic process (GO:0010664)3.25553592
106response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.23131685
107positive regulation of sodium ion transmembrane transport (GO:1902307)3.22434378
108mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.22059532
109regulation of potassium ion transmembrane transport (GO:1901379)3.20105851
110respiratory electron transport chain (GO:0022904)3.17554066
111striated muscle cell development (GO:0055002)3.16168642
112membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.15594338
113diaphragm development (GO:0060539)3.14452854
114keratinocyte proliferation (GO:0043616)3.09488971
115electron transport chain (GO:0022900)3.09148341
116positive regulation of cation channel activity (GO:2001259)3.08503599
117negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.07229544
118arginine catabolic process (GO:0006527)3.06816444
119ventricular cardiac muscle cell development (GO:0055015)3.03407093
120regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.97116008
121positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.96981632
122striated muscle adaptation (GO:0014888)2.95697669
123outflow tract septum morphogenesis (GO:0003148)2.94503121
124muscle contraction (GO:0006936)2.94248542
125apical protein localization (GO:0045176)2.91858040
126potassium ion export (GO:0071435)2.91059063
127multicellular organismal water homeostasis (GO:0050891)2.88258473
128regulation of sulfur metabolic process (GO:0042762)2.87294239
129skeletal muscle organ development (GO:0060538)2.86333842
130positive regulation of sodium ion transport (GO:0010765)2.82667692
131regulation of neurotransmitter uptake (GO:0051580)2.79006670
132auditory receptor cell differentiation (GO:0042491)2.72973937
133adenine nucleotide transport (GO:0051503)2.71177118
134microtubule bundle formation (GO:0001578)2.64444921
135negative regulation of cytosolic calcium ion concentration (GO:0051481)2.62779173
136regulation of cilium movement (GO:0003352)2.58526336
137dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.54410306
138water homeostasis (GO:0030104)2.54280415
139neurotransmitter biosynthetic process (GO:0042136)2.53722967
140nitric oxide biosynthetic process (GO:0006809)2.50682934
141intermediate filament organization (GO:0045109)2.49995631
142exogenous drug catabolic process (GO:0042738)2.45001318
143asymmetric protein localization (GO:0008105)2.44749324
144atrial cardiac muscle cell action potential (GO:0086014)2.42699914
145negative regulation of hormone biosynthetic process (GO:0032353)2.42321006
146embryonic heart tube development (GO:0035050)2.40907778
147epidermis development (GO:0008544)2.39552582
148multicellular organismal signaling (GO:0035637)2.37419653
149polarized epithelial cell differentiation (GO:0030859)2.37184967
150negative regulation of vascular permeability (GO:0043116)2.33599987
151peptidyl-cysteine modification (GO:0018198)2.33255315

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.39503333
2EP300_21415370_ChIP-Seq_HL-1_Mouse3.28443210
3TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.89119122
4* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.53384916
5ESR1_20079471_ChIP-ChIP_T-47D_Human2.46944782
6FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.41765923
7* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.33818057
8ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.32669941
9* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.32174355
10EZH2_27304074_Chip-Seq_ESCs_Mouse2.31066663
11PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.29742246
12SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.28936353
13RNF2_18974828_ChIP-Seq_MESCs_Mouse2.28259429
14EZH2_18974828_ChIP-Seq_MESCs_Mouse2.28259429
15BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.10643733
16CDX2_19796622_ChIP-Seq_MESCs_Mouse2.10549732
17* TBX20_22328084_ChIP-Seq_HEART_Mouse2.06033196
18* TBX20_22080862_ChIP-Seq_HEART_Mouse2.06033196
19* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.03246385
20JARID2_20075857_ChIP-Seq_MESCs_Mouse2.02252538
21GBX2_23144817_ChIP-Seq_PC3_Human1.99383285
22TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.98275969
23ZNF263_19887448_ChIP-Seq_K562_Human1.97945666
24* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.95969759
25* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.92696906
26* EZH2_27294783_Chip-Seq_ESCs_Mouse1.91470601
27AR_21572438_ChIP-Seq_LNCaP_Human1.90277431
28* EED_16625203_ChIP-ChIP_MESCs_Mouse1.88570513
29AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.87746203
30* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.81445348
31SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.79732180
32EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.75285612
33RNF2_27304074_Chip-Seq_ESCs_Mouse1.73877614
34ZFP57_27257070_Chip-Seq_ESCs_Mouse1.69846959
35MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.68313203
36* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.68298814
37TRIM28_21343339_ChIP-Seq_HEK293_Human1.67563096
38CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.67127683
39DROSHA_22980978_ChIP-Seq_HELA_Human1.66080111
40RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.60545753
41* TP63_23658742_ChIP-Seq_EP156T_Human1.57387304
42* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.51026815
43FOXO3_23340844_ChIP-Seq_DLD1_Human1.50788927
44FOXM1_26456572_ChIP-Seq_MCF-7_Human1.47735004
45TP63_17297297_ChIP-ChIP_HaCaT_Human1.46720605
46ZNF274_21170338_ChIP-Seq_K562_Hela1.44745538
47FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.42297240
48AHR_22903824_ChIP-Seq_MCF-7_Human1.40526623
49BMI1_23680149_ChIP-Seq_NPCS_Mouse1.40371073
50* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.37125917
51PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.36997065
52FUS_26573619_Chip-Seq_HEK293_Human1.35975292
53CBX2_27304074_Chip-Seq_ESCs_Mouse1.35495304
54SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.31596241
55* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.30418447
56STAT3_23295773_ChIP-Seq_U87_Human1.30095504
57ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.29046540
58ZNF217_24962896_ChIP-Seq_MCF-7_Human1.28773566
59SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.27627926
60* SOX2_21211035_ChIP-Seq_LN229_Gbm1.27145425
61ISL1_27105846_Chip-Seq_CPCs_Mouse1.26716714
62TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.26601855
63PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.26338467
64NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.26148469
65* RING1B_27294783_Chip-Seq_ESCs_Mouse1.25837780
66AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.25737473
67ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.24404048
68ARNT_22903824_ChIP-Seq_MCF-7_Human1.23464539
69TBL1_22424771_ChIP-Seq_293T_Human1.22853774
70ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.22231220
71RARB_27405468_Chip-Seq_BRAIN_Mouse1.21679091
72WT1_25993318_ChIP-Seq_PODOCYTE_Human1.21426426
73* SMAD4_21799915_ChIP-Seq_A2780_Human1.19682509
74ESR2_21235772_ChIP-Seq_MCF-7_Human1.19602919
75ETV1_20927104_ChIP-Seq_GIST48_Human1.19070020
76* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.17853201
77CTBP1_25329375_ChIP-Seq_LNCAP_Human1.17178681
78MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.17046883
79TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.15798624
80BCAT_22108803_ChIP-Seq_LS180_Human1.14918543
81CBX2_22325352_ChIP-Seq_293T-Rex_Human1.14535219
82SMAD3_21741376_ChIP-Seq_EPCs_Human1.14243339
83PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.13630284
84WT1_19549856_ChIP-ChIP_CCG9911_Human1.13386029
85RNF2_27304074_Chip-Seq_NSC_Mouse1.13237740
86TCF4_23295773_ChIP-Seq_U87_Human1.12872773
87TCF4_22108803_ChIP-Seq_LS180_Human1.12067721
88SMAD4_21741376_ChIP-Seq_HESCs_Human1.12004411
89FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.11890315
90TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.11659547
91PIAS1_25552417_ChIP-Seq_VCAP_Human1.11244154
92BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.11035388
93TOP2B_26459242_ChIP-Seq_MCF-7_Human1.10930835
94PHF8_20622853_ChIP-Seq_HELA_Human1.10830578
95HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.09611859
96* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.09216473
97CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.08950162
98CDX2_22108803_ChIP-Seq_LS180_Human1.08835821
99FOXA1_25552417_ChIP-Seq_VCAP_Human1.08558026
100RBPJ_21746931_ChIP-Seq_IB4_Human1.08399574
101SMAD3_21741376_ChIP-Seq_HESCs_Human1.08114986
102FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.07912021
103EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.06682539
104GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.06342121
105WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.06113815
106SOX2_20726797_ChIP-Seq_SW620_Human1.05101206
107CTBP2_25329375_ChIP-Seq_LNCAP_Human1.04396804
108* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.03649566
109NANOG_18555785_Chip-Seq_ESCs_Mouse1.03258662
110* REST_21632747_ChIP-Seq_MESCs_Mouse1.03097447
111TP53_20018659_ChIP-ChIP_R1E_Mouse1.03061902
112TP53_18474530_ChIP-ChIP_U2OS_Human1.02717498
113NFYB_21822215_ChIP-Seq_K562_Human1.02495823
114ZFP281_18757296_ChIP-ChIP_E14_Mouse1.02045055
115P53_22127205_ChIP-Seq_FIBROBLAST_Human1.01964741
116* EZH2_27294783_Chip-Seq_NPCs_Mouse1.01928348
117TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00795373
118TCF4_18268006_ChIP-ChIP_LS174T_Human1.00350756
119TP53_16413492_ChIP-PET_HCT116_Human0.99899178
120* SOX9_24532713_ChIP-Seq_HFSC_Mouse0.99887860
121ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.99809435
122EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.99435886
123SMAD4_21741376_ChIP-Seq_EPCs_Human0.97098929
124STAT6_21828071_ChIP-Seq_BEAS2B_Human0.96583572
125KDM2B_26808549_Chip-Seq_K562_Human0.96140597
126THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.95841414
127TAF15_26573619_Chip-Seq_HEK293_Human0.94778969
128NR3C1_21868756_ChIP-Seq_MCF10A_Human0.94632692
129GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94371481
130CTCF_27219007_Chip-Seq_Bcells_Human0.94235034
131* AR_19668381_ChIP-Seq_PC3_Human0.94131802
132BP1_19119308_ChIP-ChIP_Hs578T_Human0.94004647
133TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.93295087
134CJUN_26792858_Chip-Seq_BT549_Human0.92345546
135* RING1B_27294783_Chip-Seq_NPCs_Mouse0.92244013
136UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.92226670
137OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.91558636
138REST_18959480_ChIP-ChIP_MESCs_Mouse0.91234929
139RARG_19884340_ChIP-ChIP_MEFs_Mouse0.90798669
140TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.89127367
141CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.87917554
142VDR_22108803_ChIP-Seq_LS180_Human0.87762758
143AR_25329375_ChIP-Seq_VCAP_Human0.86082454
144YAP1_20516196_ChIP-Seq_MESCs_Mouse0.85882793
145ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.85197438
146MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.83397036
147GATA4_21415370_ChIP-Seq_HL-1_Mouse0.82247308
148P300_19829295_ChIP-Seq_ESCs_Human0.81527328
149KDM2B_26808549_Chip-Seq_SUP-B15_Human0.81512253

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004084_abnormal_cardiac_muscle5.29555097
2MP0002837_dystrophic_cardiac_calcinosis5.20460407
3MP0010234_abnormal_vibrissa_follicle4.78045849
4MP0000566_synostosis4.65492322
5MP0000751_myopathy4.61184863
6MP0004215_abnormal_myocardial_fiber4.50271163
7MP0003646_muscle_fatigue4.14361080
8MP0004036_abnormal_muscle_relaxation4.05534111
9MP0005330_cardiomyopathy3.43978780
10MP0000749_muscle_degeneration3.29771432
11MP0002972_abnormal_cardiac_muscle3.06308593
12MP0004145_abnormal_muscle_electrophysio3.02707758
13MP0005645_abnormal_hypothalamus_physiol3.00635723
14MP0003137_abnormal_impulse_conducting2.96575919
15MP0004043_abnormal_pH_regulation2.84793841
16MP0010678_abnormal_skin_adnexa2.78541814
17MP0004087_abnormal_muscle_fiber2.75406709
18MP0005620_abnormal_muscle_contractility2.73911281
19MP0008775_abnormal_heart_ventricle2.58428684
20MP0004484_altered_response_of2.52404373
21MP0002106_abnormal_muscle_physiology2.44698368
22MP0006138_congestive_heart_failure2.41425537
23MP0004130_abnormal_muscle_cell2.34748842
24MP0005385_cardiovascular_system_phenoty2.33501790
25MP0001544_abnormal_cardiovascular_syste2.33501790
26MP0000750_abnormal_muscle_regeneration2.32881302
27MP0004085_abnormal_heartbeat2.28893987
28MP0010630_abnormal_cardiac_muscle2.23205702
29MP0000383_abnormal_hair_follicle2.18458458
30MP0005369_muscle_phenotype1.96055756
31MP0003828_pulmonary_edema1.93512375
32MP0000747_muscle_weakness1.82079765
33MP0000467_abnormal_esophagus_morphology1.81353387
34MP0000759_abnormal_skeletal_muscle1.76552590
35MP0003045_fibrosis1.73635746
36MP0002269_muscular_atrophy1.71588328
37MP0004233_abnormal_muscle_weight1.71470417
38MP0002234_abnormal_pharynx_morphology1.70079525
39MP0004510_myositis1.65618937
40MP0003221_abnormal_cardiomyocyte_apopto1.61749729
41MP0002127_abnormal_cardiovascular_syste1.59013926
42MP0003950_abnormal_plasma_membrane1.52147406
43MP0003567_abnormal_fetal_cardiomyocyte1.50143340
44MP0004782_abnormal_surfactant_physiolog1.43827064
45MP0009053_abnormal_anal_canal1.41797643
46MP0004859_abnormal_synaptic_plasticity1.37657618
47MP0005409_darkened_coat_color1.36794833
48MP0003283_abnormal_digestive_organ1.32496431
49MP0003011_delayed_dark_adaptation1.31988589
50MP0001501_abnormal_sleep_pattern1.28215076
51MP0010368_abnormal_lymphatic_system1.20788505
52MP0002332_abnormal_exercise_endurance1.18520416
53MP0000762_abnormal_tongue_morphology1.15981390
54MP0003880_abnormal_central_pattern1.11035789
55MP0002009_preneoplasia1.09046870
56MP0003941_abnormal_skin_development1.08720446
57MP0002876_abnormal_thyroid_physiology1.07717070
58MP0001958_emphysema1.05974118
59MP0003718_maternal_effect1.05913475
60MP0004858_abnormal_nervous_system1.05125416
61MP0005167_abnormal_blood-brain_barrier1.04048989
62MP0002098_abnormal_vibrissa_morphology1.01327800
63MP0006036_abnormal_mitochondrial_physio1.01240816
64MP0005623_abnormal_meninges_morphology0.98655842
65MP0002282_abnormal_trachea_morphology0.98010819
66MP0005187_abnormal_penis_morphology0.97954585
67MP0005646_abnormal_pituitary_gland0.97125276
68MP0003635_abnormal_synaptic_transmissio0.96697422
69MP0005165_increased_susceptibility_to0.96399249
70MP0004270_analgesia0.96060794
71MP0000266_abnormal_heart_morphology0.95902878
72MP0004272_abnormal_basement_membrane0.95721619
73MP0001756_abnormal_urination0.95704879
74MP0002233_abnormal_nose_morphology0.93527627
75MP0004019_abnormal_vitamin_homeostasis0.92803869
76MP0000427_abnormal_hair_cycle0.92173389
77MP0002638_abnormal_pupillary_reflex0.90694768
78MP0003453_abnormal_keratinocyte_physiol0.90459095
79MP0001502_abnormal_circadian_rhythm0.89086473
80MP0000377_abnormal_hair_follicle0.87799538
81MP0009780_abnormal_chondrocyte_physiolo0.87097497
82MP0005666_abnormal_adipose_tissue0.87094741
83MP0001216_abnormal_epidermal_layer0.87093751
84MP0000647_abnormal_sebaceous_gland0.86435214
85MP0002909_abnormal_adrenal_gland0.86185928
86MP0009046_muscle_twitch0.83425248
87MP0001440_abnormal_grooming_behavior0.83046392
88MP0001944_abnormal_pancreas_morphology0.82803920
89MP0002060_abnormal_skin_morphology0.82624999
90MP0004885_abnormal_endolymph0.81617688
91MP0001661_extended_life_span0.79572862
92MP0004185_abnormal_adipocyte_glucose0.78923743
93MP0009384_cardiac_valve_regurgitation0.77125961
94MP0000778_abnormal_nervous_system0.75946668
95MP0005275_abnormal_skin_tensile0.75121456
96MP0000631_abnormal_neuroendocrine_gland0.75104069
97MP0002133_abnormal_respiratory_system0.74393249
98MP0005388_respiratory_system_phenotype0.74393249
99MP0003937_abnormal_limbs/digits/tail_de0.73808901
100MP0002108_abnormal_muscle_morphology0.73349167
101MP0001879_abnormal_lymphatic_vessel0.73332715
102MP0001984_abnormal_olfaction0.71458063
103MP0006035_abnormal_mitochondrial_morpho0.70886216
104* MP0002063_abnormal_learning/memory/cond0.69913257
105MP0003329_amyloid_beta_deposits0.68846789
106MP0005501_abnormal_skin_physiology0.68587741
107MP0003279_aneurysm0.68291511
108MP0005174_abnormal_tail_pigmentation0.67578977
109MP0005423_abnormal_somatic_nervous0.67249959
110MP0005386_behavior/neurological_phenoty0.66809057
111MP0004924_abnormal_behavior0.66809057
112MP0001765_abnormal_ion_homeostasis0.65914418
113MP0000579_abnormal_nail_morphology0.65806222
114MP0004133_heterotaxia0.65650689
115MP0008789_abnormal_olfactory_epithelium0.65436821
116MP0010771_integument_phenotype0.65393042
117MP0003566_abnormal_cell_adhesion0.65220181
118MP0000343_altered_response_to0.64684904
119MP0000230_abnormal_systemic_arterial0.64150354
120MP0002128_abnormal_blood_circulation0.63119236
121MP0002184_abnormal_innervation0.62691231
122MP0002295_abnormal_pulmonary_circulatio0.62430332
123MP0002735_abnormal_chemical_nociception0.62368688
124MP0005375_adipose_tissue_phenotype0.62318947
125MP0008004_abnormal_stomach_pH0.62244226
126* MP0009745_abnormal_behavioral_response0.61557527
127MP0005367_renal/urinary_system_phenotyp0.61054467
128MP0000516_abnormal_urinary_system0.61054467
129MP0002168_other_aberrant_phenotype0.59763066
130MP0004134_abnormal_chest_morphology0.58157677
131MP0000538_abnormal_urinary_bladder0.57700251
132MP0001968_abnormal_touch/_nociception0.57383881
133MP0000613_abnormal_salivary_gland0.56939931
134MP0002067_abnormal_sensory_capabilities0.56159516
135MP0004381_abnormal_hair_follicle0.55722963
136MP0002796_impaired_skin_barrier0.54781924
137MP0000537_abnormal_urethra_morphology0.54359274
138MP0000733_abnormal_muscle_development0.54349713
139MP0005377_hearing/vestibular/ear_phenot0.53731602
140MP0003878_abnormal_ear_physiology0.53731602
141MP0008569_lethality_at_weaning0.53726470
142MP0002734_abnormal_mechanical_nocicepti0.52974406
143MP0000013_abnormal_adipose_tissue0.50811011
144MP0003948_abnormal_gas_homeostasis0.50515898
145MP0001486_abnormal_startle_reflex0.50459396
146MP0002572_abnormal_emotion/affect_behav0.50108788
147MP0006276_abnormal_autonomic_nervous0.48998861
148MP0003385_abnormal_body_wall0.48751556
149MP0002736_abnormal_nociception_after0.48277682
150MP0001784_abnormal_fluid_regulation0.48200069
151MP0002925_abnormal_cardiovascular_devel0.47670599

Predicted human phenotypes

RankGene SetZ-score
1Sudden death (HP:0001699)8.24245658
2Ventricular tachycardia (HP:0004756)6.13968041
3Exercise-induced myalgia (HP:0003738)5.96084020
4Respiratory insufficiency due to defective ciliary clearance (HP:0200073)5.84641956
5Atrial fibrillation (HP:0005110)5.68116392
6Calf muscle hypertrophy (HP:0008981)5.67508497
7Exercise-induced muscle cramps (HP:0003710)5.65988415
8Muscle hypertrophy of the lower extremities (HP:0008968)5.43287753
9Syncope (HP:0001279)5.42663079
10Primary atrial arrhythmia (HP:0001692)5.39840155
11Supraventricular tachycardia (HP:0004755)5.18605140
12Lip pit (HP:0100267)5.09934474
13Supraventricular arrhythmia (HP:0005115)5.09078910
14Abnormality of the calf musculature (HP:0001430)4.98420270
15Abnormality of the left ventricular outflow tract (HP:0011103)4.94534967
16Subaortic stenosis (HP:0001682)4.94534967
17Right ventricular cardiomyopathy (HP:0011663)4.89424166
18Abnormal respiratory epithelium morphology (HP:0012253)4.81267928
19Abnormal respiratory motile cilium morphology (HP:0005938)4.81267928
20Abnormal respiratory motile cilium physiology (HP:0012261)4.72294644
21Rhinitis (HP:0012384)4.72245918
22Prolonged QT interval (HP:0001657)4.66924655
23Hyporeflexia of lower limbs (HP:0002600)4.64908919
24Muscle fiber splitting (HP:0003555)4.52795290
25Lipoatrophy (HP:0100578)4.44190980
26Ventricular fibrillation (HP:0001663)4.31061358
27Abnormal ciliary motility (HP:0012262)4.27544870
28Ventricular arrhythmia (HP:0004308)4.19246788
29Dynein arm defect of respiratory motile cilia (HP:0012255)4.17549089
30Absent/shortened dynein arms (HP:0200106)4.17549089
31Popliteal pterygium (HP:0009756)4.00637853
32Myoglobinuria (HP:0002913)3.99159381
33Bundle branch block (HP:0011710)3.87897206
34Palpitations (HP:0001962)3.81174957
35EMG: myopathic abnormalities (HP:0003458)3.78761214
36Abnormality of nail color (HP:0100643)3.66911966
37Dilated cardiomyopathy (HP:0001644)3.61510102
38Chronic bronchitis (HP:0004469)3.60804616
39Asymmetric septal hypertrophy (HP:0001670)3.52095421
40Abnormal EKG (HP:0003115)3.47505167
41Myotonia (HP:0002486)3.39600988
42Bronchiectasis (HP:0002110)3.31928230
43Heart block (HP:0012722)3.21773700
44Difficulty running (HP:0009046)3.16780137
45Abnormal atrioventricular conduction (HP:0005150)3.04891109
46Atrioventricular block (HP:0001678)3.04527196
47Hypoplastic labia majora (HP:0000059)3.02417147
48Plantar hyperkeratosis (HP:0007556)3.01491819
49Type 1 muscle fiber predominance (HP:0003803)2.97852444
50Alopecia of scalp (HP:0002293)2.95086264
51Rhabdomyolysis (HP:0003201)2.91108696
52Palmoplantar hyperkeratosis (HP:0000972)2.85888003
53Left ventricular hypertrophy (HP:0001712)2.82037167
54Abnormality of the labia majora (HP:0012881)2.80499588
55Increased connective tissue (HP:0009025)2.79127926
56Double outlet right ventricle (HP:0001719)2.78723046
57Congenital malformation of the right heart (HP:0011723)2.78723046
58Muscle fiber inclusion bodies (HP:0100299)2.77457406
59Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.76735861
60Sparse lateral eyebrow (HP:0005338)2.75699487
61Onycholysis (HP:0001806)2.75150589
62Depressed nasal tip (HP:0000437)2.72425929
63Palmar hyperkeratosis (HP:0010765)2.67471087
64Hypoglycemic coma (HP:0001325)2.61190193
65Conjunctival hamartoma (HP:0100780)2.60895668
66Acute necrotizing encephalopathy (HP:0006965)2.57171724
67Palmoplantar keratoderma (HP:0000982)2.57005626
68Abnormal mitochondria in muscle tissue (HP:0008316)2.50620283
69Muscle stiffness (HP:0003552)2.50520225
70Pancreatic fibrosis (HP:0100732)2.46573484
71Absent eyelashes (HP:0000561)2.37802951
72Increased variability in muscle fiber diameter (HP:0003557)2.37335047
73Fragile nails (HP:0001808)2.36686237
74Neck muscle weakness (HP:0000467)2.33769026
75Hypothermia (HP:0002045)2.33334260
76Hypoplastic left heart (HP:0004383)2.32931454
77Fetal akinesia sequence (HP:0001989)2.32499005
78Abnormality of the renal cortex (HP:0011035)2.30804415
79Nemaline bodies (HP:0003798)2.29606090
80Tubular atrophy (HP:0000092)2.29072249
81Sudden cardiac death (HP:0001645)2.26384324
82Thick nail (HP:0001805)2.26329982
83Difficulty climbing stairs (HP:0003551)2.25585877
84Progressive macrocephaly (HP:0004481)2.24514595
85Distal lower limb muscle weakness (HP:0009053)2.19048971
86Nasal polyposis (HP:0100582)2.16808593
87Abnormality of skeletal muscle fiber size (HP:0012084)2.16534223
88Preauricular pit (HP:0004467)2.13828209
89Periauricular skin pits (HP:0100277)2.13828209
90Mildly elevated creatine phosphokinase (HP:0008180)2.13378163
91Abnormality of the dental root (HP:0006486)2.13259616
92Taurodontia (HP:0000679)2.13259616
93Abnormality of permanent molar morphology (HP:0011071)2.13259616
94Anal stenosis (HP:0002025)2.12945522
95Pili torti (HP:0003777)2.10090541
96Hamartoma of the eye (HP:0010568)2.09454520
97Labial hypoplasia (HP:0000066)2.08723911
98Pheochromocytoma (HP:0002666)2.06319904
99Rimmed vacuoles (HP:0003805)2.02884159
100Proximal tubulopathy (HP:0000114)2.02499414
101Skin pits (HP:0100276)2.02117474
102Furrowed tongue (HP:0000221)2.01878523
103Pancreatic cysts (HP:0001737)2.01509860
104Areflexia of lower limbs (HP:0002522)2.01097800
105Abnormality of the foot musculature (HP:0001436)1.99442274
106Acute encephalopathy (HP:0006846)1.98055240
107Increased CSF protein (HP:0002922)1.97709082
108Abnormality of molar (HP:0011077)1.96057193
109Abnormality of molar morphology (HP:0011070)1.96057193
110Ragged-red muscle fibers (HP:0003200)1.94757021
111Hepatic necrosis (HP:0002605)1.93823637
112EMG: neuropathic changes (HP:0003445)1.93736451
113Hypotrichosis (HP:0001006)1.93380413
114Limb-girdle muscle atrophy (HP:0003797)1.91200417
115Ketoacidosis (HP:0001993)1.91028732
116Mitochondrial inheritance (HP:0001427)1.88393024
117Infertility (HP:0000789)1.87721115
118Broad metatarsal (HP:0001783)1.86433052
119Recurrent otitis media (HP:0000403)1.85680973
120True hermaphroditism (HP:0010459)1.85622562
121Rapidly progressive (HP:0003678)1.85444622
122Abnormality of the dental pulp (HP:0006479)1.85336215
123Gowers sign (HP:0003391)1.84428150
124Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.84090749
125Milia (HP:0001056)1.83478649
126Hypoplastic heart (HP:0001961)1.82483746
127Scapular winging (HP:0003691)1.80773728
128Respiratory failure (HP:0002878)1.80747920
129Hypoplastic female external genitalia (HP:0012815)1.80108278
130Frequent falls (HP:0002359)1.79989017
131Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.79398775
132Neuroendocrine neoplasm (HP:0100634)1.78830036
133Abnormal hair laboratory examination (HP:0003328)1.78499795
134Chronic sinusitis (HP:0011109)1.78461897
135Renal cortical cysts (HP:0000803)1.78093117
136Exercise intolerance (HP:0003546)1.77932871
137Absent eyebrow (HP:0002223)1.77819863
138Foot dorsiflexor weakness (HP:0009027)1.77315832
139Ectropion (HP:0000656)1.77180224
140Hypoplastic ischia (HP:0003175)1.76034466
141Nephronophthisis (HP:0000090)1.74905321
142Congestive heart failure (HP:0001635)1.74002337
143Hepatocellular necrosis (HP:0001404)1.73055494
144Neoplasm of the adrenal gland (HP:0100631)1.72060172
145Tachypnea (HP:0002789)1.71430867
146Increased CSF lactate (HP:0002490)1.71329069
147Centrally nucleated skeletal muscle fibers (HP:0003687)1.70375824
148Abnormality of glycolysis (HP:0004366)1.69530647
149Increased serum pyruvate (HP:0003542)1.69530647
150Muscular dystrophy (HP:0003560)1.68974173
151Median cleft lip (HP:0000161)1.68084983
152Tubulointerstitial fibrosis (HP:0005576)1.67961757
153Lower limb amyotrophy (HP:0007210)1.66557243
154Generalized muscle weakness (HP:0003324)1.64295693
155Steppage gait (HP:0003376)1.62184070
156Hyperalaninemia (HP:0003348)1.61363987
157Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.61363987
158Abnormality of alanine metabolism (HP:0010916)1.61363987
159Athetosis (HP:0002305)1.60688581
160Distal arthrogryposis (HP:0005684)1.59141293
161Abnormality of the tricuspid valve (HP:0001702)1.55957499
162Visual hallucinations (HP:0002367)1.55668483
163Round ear (HP:0100830)1.55267562
164Cerebral edema (HP:0002181)1.54250637

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PHKG14.49097340
2PHKG24.49097340
3OBSCN4.09702781
4FRK3.85938496
5TTN3.70005510
6MST43.56677924
7LMTK23.14138864
8MYLK3.03422714
9PDK32.92589589
10PDK42.92589589
11MARK12.77243733
12DMPK2.57959373
13PKN22.52882226
14EEF2K2.50965377
15MAPK152.44667016
16TRIB32.07670544
17TIE12.05257682
18PIK3CA2.02578527
19CCNB11.88863840
20PNCK1.82736246
21* STK241.73225778
22MUSK1.70572100
23NEK11.64792502
24MAP4K21.58769633
25PAK31.58111180
26GRK11.55712428
27PDK21.54386566
28GRK71.50418808
29EPHA21.43737839
30LIMK11.24819275
31MAPK121.24009616
32MAP3K71.19403877
33CDC42BPA1.18735659
34CAMK2D1.17867544
35STK31.16989847
36ARAF1.16221796
37ROCK11.15584265
38NTRK31.15150840
39MAP3K41.13341842
40MAP3K91.12851130
41ERBB31.11550743
42EPHB21.08362928
43PRKD11.06781683
44PINK11.06727003
45WNK41.02961937
46FER1.02811169
47MAP2K41.02151102
48NME10.99354628
49MET0.99079244
50CAMK2A0.97938611
51LATS20.95616353
52MST1R0.90512326
53PKN10.89019498
54PTK2B0.88339394
55MINK10.86899687
56CAMK1G0.86137989
57EPHA40.84883438
58CSNK1G20.84871131
59RIPK10.79400932
60CAMK10.78878408
61STK390.77808136
62PRKCE0.76937229
63MAPKAPK50.76796949
64ROCK20.75799959
65STK38L0.75671251
66PAK60.75647872
67DAPK30.75060951
68MAP3K50.74520163
69PDGFRA0.74459519
70LATS10.74225491
71FGFR20.73683742
72NTRK20.72729053
73CASK0.71253731
74MAPK130.71077251
75BMPR1B0.70510042
76KSR20.70217425
77PRKAA10.69771570
78CSNK1G10.69201585
79MAPKAPK30.67450596
80BCKDK0.65978605
81PTK20.64988134
82KSR10.63153051
83NEK90.63011513
84PRKCI0.61826345
85DYRK20.61750172
86STK380.61483848
87CAMK40.61383650
88TGFBR10.60725813
89MAP3K30.60083647
90TRIM280.59962528
91PRKAA20.58987460
92PLK20.58858411
93* ILK0.58166048
94CSNK1G30.57539249
95MKNK20.56870923
96AKT30.56341176
97PIK3CG0.53866925
98PRKCG0.53320116
99TRPM70.52469630
100PRKD30.52269822
101DAPK20.52189370
102ZAK0.52099664
103RET0.51836965
104INSRR0.51532533
105UHMK10.49076099
106GRK50.48397394
107* PRKACA0.48322263
108MAP2K70.48023221
109RPS6KA20.46576173
110MAP3K120.46310202
111CDK50.44689664
112PRKACB0.42746277
113OXSR10.42530014
114CAMK2G0.42445836
115EPHA30.42423119
116CAMKK20.41957556
117ERBB20.41807698
118STK40.41541549
119MAP3K20.41263897
120ADRBK20.41148753
121DYRK30.40304228
122RPS6KB20.39720243
123CSNK1A1L0.39626761
124SGK30.38766603
125FGFR30.38002540
126PDGFRB0.37868736
127PRKACG0.37748015
128BRSK20.37451240
129TAOK10.37270779
130WNK10.37145656
131SGK4940.37130349
132SGK2230.37130349
133MAP2K60.37114325
134ICK0.36904930
135SGK20.36416133
136STK110.34906467
137FGFR10.34604767
138RPS6KB10.33268404
139TTK0.33127339
140CAMK2B0.32512578
141PDPK10.31801790
142SGK10.31524474
143ADRBK10.31341252
144TNIK0.30773737
145BCR0.30637581
146MAP2K10.30611742
147MARK20.30427451
148PRKG10.29527899

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000204.18969819
2Cardiac muscle contraction_Homo sapiens_hsa042604.04774177
3Dilated cardiomyopathy_Homo sapiens_hsa054143.49541625
4Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054103.33485099
5Parkinsons disease_Homo sapiens_hsa050122.66702686
6Oxidative phosphorylation_Homo sapiens_hsa001902.66417334
7Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.65354562
82-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.61174588
9Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042612.27193886
10Arginine biosynthesis_Homo sapiens_hsa002202.25077649
11Maturity onset diabetes of the young_Homo sapiens_hsa049502.23571607
12Alzheimers disease_Homo sapiens_hsa050102.22134729
13Propanoate metabolism_Homo sapiens_hsa006401.87932538
14Fatty acid degradation_Homo sapiens_hsa000711.73573531
15Huntingtons disease_Homo sapiens_hsa050161.69272930
16Phototransduction_Homo sapiens_hsa047441.66493668
17Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.61939198
18Vitamin B6 metabolism_Homo sapiens_hsa007501.58277005
19Sphingolipid metabolism_Homo sapiens_hsa006001.53488931
20Nitrogen metabolism_Homo sapiens_hsa009101.48770653
21Viral myocarditis_Homo sapiens_hsa054161.46988790
22Olfactory transduction_Homo sapiens_hsa047401.46940567
23Oxytocin signaling pathway_Homo sapiens_hsa049211.46788735
24Arginine and proline metabolism_Homo sapiens_hsa003301.46777495
25Fatty acid metabolism_Homo sapiens_hsa012121.46077254
26cGMP-PKG signaling pathway_Homo sapiens_hsa040221.42281038
27Mineral absorption_Homo sapiens_hsa049781.41009400
28Histidine metabolism_Homo sapiens_hsa003401.39777298
29Circadian entrainment_Homo sapiens_hsa047131.39762261
30Renin secretion_Homo sapiens_hsa049241.38751806
31Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.35142370
32Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.33355728
33Calcium signaling pathway_Homo sapiens_hsa040201.32709358
34Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.31361936
35Carbon metabolism_Homo sapiens_hsa012001.29723694
36Gastric acid secretion_Homo sapiens_hsa049711.24680506
37Phenylalanine metabolism_Homo sapiens_hsa003601.22198491
38Sulfur metabolism_Homo sapiens_hsa009201.21463324
39Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.15662899
40Tyrosine metabolism_Homo sapiens_hsa003501.15200214
41Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.12710651
42Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.12106222
43Fatty acid elongation_Homo sapiens_hsa000621.10734712
44Long-term potentiation_Homo sapiens_hsa047201.09515389
45Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.09316309
46Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.08263403
47Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.07520385
48Tight junction_Homo sapiens_hsa045301.07198823
49Glucagon signaling pathway_Homo sapiens_hsa049221.07119531
50Axon guidance_Homo sapiens_hsa043601.06707098
51beta-Alanine metabolism_Homo sapiens_hsa004101.05510773
52Vascular smooth muscle contraction_Homo sapiens_hsa042701.01039746
53Taste transduction_Homo sapiens_hsa047421.00456818
54Pyruvate metabolism_Homo sapiens_hsa006200.99022246
55Insulin signaling pathway_Homo sapiens_hsa049100.97966082
56Linoleic acid metabolism_Homo sapiens_hsa005910.97598244
57Insulin secretion_Homo sapiens_hsa049110.97363920
58Butanoate metabolism_Homo sapiens_hsa006500.97003110
59Cholinergic synapse_Homo sapiens_hsa047250.95247122
60Protein export_Homo sapiens_hsa030600.95144597
61Aldosterone synthesis and secretion_Homo sapiens_hsa049250.94043779
62GnRH signaling pathway_Homo sapiens_hsa049120.93934904
63Collecting duct acid secretion_Homo sapiens_hsa049660.93258150
64Glutamatergic synapse_Homo sapiens_hsa047240.93069409
65Dopaminergic synapse_Homo sapiens_hsa047280.92700324
66Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.92444463
67cAMP signaling pathway_Homo sapiens_hsa040240.91781865
68Morphine addiction_Homo sapiens_hsa050320.91173649
69Peroxisome_Homo sapiens_hsa041460.90924826
70Nicotine addiction_Homo sapiens_hsa050330.89801246
71Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.89704791
72Focal adhesion_Homo sapiens_hsa045100.89597524
73Salivary secretion_Homo sapiens_hsa049700.88715628
74GABAergic synapse_Homo sapiens_hsa047270.88378425
75Chemical carcinogenesis_Homo sapiens_hsa052040.85957439
76Insulin resistance_Homo sapiens_hsa049310.85494406
77Gap junction_Homo sapiens_hsa045400.84794439
78Amphetamine addiction_Homo sapiens_hsa050310.84128249
79Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.82541598
80Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.80503745
81Regulation of autophagy_Homo sapiens_hsa041400.79313883
82Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.76582929
83Glutathione metabolism_Homo sapiens_hsa004800.75642481
84Ether lipid metabolism_Homo sapiens_hsa005650.74732950
85Type II diabetes mellitus_Homo sapiens_hsa049300.74485870
86Serotonergic synapse_Homo sapiens_hsa047260.74273234
87Adipocytokine signaling pathway_Homo sapiens_hsa049200.71541927
88Adherens junction_Homo sapiens_hsa045200.70255765
89Melanogenesis_Homo sapiens_hsa049160.68670940
90ECM-receptor interaction_Homo sapiens_hsa045120.68574087
91Hedgehog signaling pathway_Homo sapiens_hsa043400.68096563
92AMPK signaling pathway_Homo sapiens_hsa041520.67341518
93ABC transporters_Homo sapiens_hsa020100.65976134
94Renal cell carcinoma_Homo sapiens_hsa052110.65847049
95Phosphatidylinositol signaling system_Homo sapiens_hsa040700.65219876
96Estrogen signaling pathway_Homo sapiens_hsa049150.64601039
97Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.64336161
98Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.64063569
99Fatty acid biosynthesis_Homo sapiens_hsa000610.63845661
100Thyroid hormone signaling pathway_Homo sapiens_hsa049190.61840159
101Thyroid hormone synthesis_Homo sapiens_hsa049180.60477627
102Central carbon metabolism in cancer_Homo sapiens_hsa052300.60134304
103Long-term depression_Homo sapiens_hsa047300.59736940
104VEGF signaling pathway_Homo sapiens_hsa043700.59450608
105Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.56946353
106Dorso-ventral axis formation_Homo sapiens_hsa043200.56799334
107Circadian rhythm_Homo sapiens_hsa047100.56371376
108Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.54848469
109alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.54004317
110HIF-1 signaling pathway_Homo sapiens_hsa040660.53070014
111Primary bile acid biosynthesis_Homo sapiens_hsa001200.52777800
112Inositol phosphate metabolism_Homo sapiens_hsa005620.52246964
113Retinol metabolism_Homo sapiens_hsa008300.50256820
114Amoebiasis_Homo sapiens_hsa051460.49078001
115Longevity regulating pathway - mammal_Homo sapiens_hsa042110.48992358
116Regulation of actin cytoskeleton_Homo sapiens_hsa048100.47949009
117Steroid hormone biosynthesis_Homo sapiens_hsa001400.47525351
118Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.47074571
119Glioma_Homo sapiens_hsa052140.46752586
120Sphingolipid signaling pathway_Homo sapiens_hsa040710.46418178
121ErbB signaling pathway_Homo sapiens_hsa040120.46030823
122Tryptophan metabolism_Homo sapiens_hsa003800.45384177
123Endometrial cancer_Homo sapiens_hsa052130.43778465
124PPAR signaling pathway_Homo sapiens_hsa033200.42077917
125Pancreatic secretion_Homo sapiens_hsa049720.41577435
126Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.41218264
127MAPK signaling pathway_Homo sapiens_hsa040100.40411001
128Rap1 signaling pathway_Homo sapiens_hsa040150.38532749
129Synaptic vesicle cycle_Homo sapiens_hsa047210.38136638
130Hippo signaling pathway_Homo sapiens_hsa043900.37580847
131Proteoglycans in cancer_Homo sapiens_hsa052050.35533099
132Cocaine addiction_Homo sapiens_hsa050300.35466399
133Starch and sucrose metabolism_Homo sapiens_hsa005000.35079606
134Ovarian steroidogenesis_Homo sapiens_hsa049130.33820924
135Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.32795590
136Leukocyte transendothelial migration_Homo sapiens_hsa046700.32404108
137Ras signaling pathway_Homo sapiens_hsa040140.32403059
138Phospholipase D signaling pathway_Homo sapiens_hsa040720.30739382
139Platelet activation_Homo sapiens_hsa046110.30730214

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