PPP1R15A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The induction of this gene by ionizing radiation occurs in certain cell lines regardless of p53 status, and its protein response is correlated with apoptosis following ionizing radiation. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1tolerance induction (GO:0002507)4.92028517
2NIK/NF-kappaB signaling (GO:0038061)4.55589779
3response to muramyl dipeptide (GO:0032495)4.33212855
4regulation of interleukin-12 biosynthetic process (GO:0045075)4.25008373
5negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.84312614
6positive regulation of gamma-delta T cell activation (GO:0046645)3.83519689
7hepatocyte apoptotic process (GO:0097284)3.67276554
8neutrophil activation involved in immune response (GO:0002283)3.52177298
9regulation of germinal center formation (GO:0002634)3.50977622
10negative regulation of interleukin-12 production (GO:0032695)3.49049521
11regulation of dendritic cell antigen processing and presentation (GO:0002604)3.48723730
12positive regulation of p38MAPK cascade (GO:1900745)3.36372531
13antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.32629990
14antigen processing and presentation of endogenous antigen (GO:0019883)3.32016507
15regulation of chronic inflammatory response (GO:0002676)3.29700661
16positive regulation of antigen processing and presentation (GO:0002579)3.29174824
17regulation of RIG-I signaling pathway (GO:0039535)3.25398744
18granulocyte activation (GO:0036230)3.24101188
19megakaryocyte development (GO:0035855)3.23115119
20G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.21619603
21regulation of vitamin D biosynthetic process (GO:0060556)3.19150353
22negative regulation of interleukin-1 beta production (GO:0032691)3.18854990
23activation of MAPKKK activity (GO:0000185)3.18202524
24neutrophil activation (GO:0042119)3.16868150
25antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.16767967
26antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.16767967
27definitive hemopoiesis (GO:0060216)3.13127521
28negative regulation of interleukin-6 production (GO:0032715)3.11411104
29positive regulation of heat generation (GO:0031652)3.11353956
30negative regulation of innate immune response (GO:0045824)3.11173545
31negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.10979217
32positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.07712915
33regulation of gamma-delta T cell activation (GO:0046643)3.04851630
34negative regulation of bone resorption (GO:0045779)3.04142146
35negative regulation of T cell mediated immunity (GO:0002710)3.02461231
36myeloid dendritic cell activation (GO:0001773)3.00493420
37myeloid dendritic cell differentiation (GO:0043011)2.99035453
38negative regulation of lipid storage (GO:0010888)2.98094610
39nucleotide-binding oligomerization domain containing signaling pathway (GO:0070423)2.97922861
40erythrocyte maturation (GO:0043249)2.97668513
41immunoglobulin mediated immune response (GO:0016064)2.97419433
42positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.95744055
43leukocyte aggregation (GO:0070486)2.93214541
44regulation of mast cell degranulation (GO:0043304)2.92956358
45defense response to protozoan (GO:0042832)2.91108930
46regulation of gamma-delta T cell differentiation (GO:0045586)2.90126308
47response to type I interferon (GO:0034340)2.89351968
48T cell migration (GO:0072678)2.88888916
49positive regulation of chemokine biosynthetic process (GO:0045080)2.88498118
50positive regulation of mRNA catabolic process (GO:0061014)2.87994023
51regulation of T-helper 1 cell differentiation (GO:0045625)2.87795925
52microglial cell activation (GO:0001774)2.87470972
53negative thymic T cell selection (GO:0045060)2.87168166
54regulation of antigen processing and presentation (GO:0002577)2.85479631
55negative regulation of cell killing (GO:0031342)2.83777330
56negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.83777330
57macrophage activation involved in immune response (GO:0002281)2.83672348
58negative regulation of interleukin-1 production (GO:0032692)2.83057755
59regulation of T-helper 2 cell differentiation (GO:0045628)2.82658855
60positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.81568864
61regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.81568864
62cellular extravasation (GO:0045123)2.81437406
63type I interferon signaling pathway (GO:0060337)2.81375129
64cellular response to type I interferon (GO:0071357)2.81375129
65negative regulation of cytokine production involved in immune response (GO:0002719)2.80130518
66regulation of fever generation (GO:0031620)2.79387459
67negative regulation of lymphocyte mediated immunity (GO:0002707)2.78508662
68embryonic hemopoiesis (GO:0035162)2.78399599
69interferon-gamma production (GO:0032609)2.77026422
70regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.75063076
71cytoplasmic pattern recognition receptor signaling pathway (GO:0002753)2.74871688
72interferon-gamma-mediated signaling pathway (GO:0060333)2.74804719
73regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.74320014
74response to peptidoglycan (GO:0032494)2.73469626
75positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.72667138
76sleep (GO:0030431)2.72533097
77RNA destabilization (GO:0050779)2.72469733
78macrophage activation (GO:0042116)2.71791425
79modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.71389276
80positive regulation by organism of defense response of other organism involved in symbiotic interact2.71389276
81modulation by symbiont of host immune response (GO:0052553)2.71389276
82positive regulation by symbiont of host defense response (GO:0052509)2.71389276
83modulation by symbiont of host defense response (GO:0052031)2.71389276
84modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.71389276
85regulation of response to interferon-gamma (GO:0060330)2.70609611
86JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.70317426
87negative T cell selection (GO:0043383)2.70211821
88interleukin-1-mediated signaling pathway (GO:0070498)2.70094223
89regulation of toll-like receptor 4 signaling pathway (GO:0034143)2.68245049
90negative regulation of leukocyte mediated immunity (GO:0002704)2.68141837
91CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.67530171
92alpha-beta T cell differentiation involved in immune response (GO:0002293)2.66186731
93alpha-beta T cell activation involved in immune response (GO:0002287)2.66186731
94T cell differentiation involved in immune response (GO:0002292)2.66186731
95angiogenesis involved in wound healing (GO:0060055)2.65939923
96regulation of mast cell activation involved in immune response (GO:0033006)2.65764262
97regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.65560639
98germinal center formation (GO:0002467)2.64532388
99positive regulation of cholesterol efflux (GO:0010875)2.63850179
100myeloid cell activation involved in immune response (GO:0002275)2.63629661
101negative regulation of protein autophosphorylation (GO:0031953)2.63209991
102regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.62424567
103protoporphyrinogen IX metabolic process (GO:0046501)2.61789195
104B cell homeostasis (GO:0001782)2.61707227
105mature B cell differentiation involved in immune response (GO:0002313)2.61610622
106response to progesterone (GO:0032570)2.61380896
107positive regulation of natural killer cell differentiation (GO:0032825)2.59995797
108regulation of T cell mediated cytotoxicity (GO:0001914)2.59256768
109positive regulation of T-helper 1 type immune response (GO:0002827)2.59027485
110positive regulation of interleukin-2 production (GO:0032743)2.58524681
111regulation of mast cell activation (GO:0033003)2.57761066
112detection of other organism (GO:0098543)2.56042106
113regulation of alpha-beta T cell proliferation (GO:0046640)2.55862859
114positive regulation of type 2 immune response (GO:0002830)2.55749545
115regulation of leukocyte degranulation (GO:0043300)2.55716921
116regulation of necroptotic process (GO:0060544)2.55422929
117negative regulation of nitric oxide biosynthetic process (GO:0045019)2.52551001
118dendritic cell differentiation (GO:0097028)2.52521933
119regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.52107367
120regulation of mRNA catabolic process (GO:0061013)2.49471877
121regulation of interferon-beta biosynthetic process (GO:0045357)2.49052974
122nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway (GO:0035872)2.47963251
123mitotic cell cycle arrest (GO:0071850)2.47930850
124erythrocyte development (GO:0048821)2.47698530
125regulation of fibroblast apoptotic process (GO:2000269)2.47030336
126T-helper cell differentiation (GO:0042093)2.46687567
127CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.46687567
128positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.44962398
129leukocyte tethering or rolling (GO:0050901)2.44625281
130positive regulation of interleukin-12 production (GO:0032735)2.43809408
131negative regulation of erythrocyte differentiation (GO:0045647)2.42285486
132negative regulation of granulocyte differentiation (GO:0030853)2.41979791
133response to laminar fluid shear stress (GO:0034616)2.40709857
134positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.40094820
135dendritic cell chemotaxis (GO:0002407)2.39505672
136regulation of B cell receptor signaling pathway (GO:0050855)2.39115098
137regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.38645129
138positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.38645129
139cellular response to interleukin-15 (GO:0071350)2.38389958
140myeloid leukocyte activation (GO:0002274)2.38358662
141endoderm formation (GO:0001706)2.37991252
142positive thymic T cell selection (GO:0045059)2.37981885
143energy homeostasis (GO:0097009)2.37867069
144response to interferon-beta (GO:0035456)2.37625321
145positive regulation of interferon-beta production (GO:0032728)2.37424010
146T cell activation involved in immune response (GO:0002286)2.35221547
147regulation of cell proliferation involved in kidney development (GO:1901722)2.34195859
148regulation of chemokine biosynthetic process (GO:0045073)2.32856850
149lipopolysaccharide-mediated signaling pathway (GO:0031663)2.31699925
150purinergic nucleotide receptor signaling pathway (GO:0035590)2.31695223
151response to interleukin-15 (GO:0070672)2.31478114
152response to protozoan (GO:0001562)2.31007144
153protoporphyrinogen IX biosynthetic process (GO:0006782)2.30962741
154myeloid cell development (GO:0061515)2.30169105
155positive regulation of interferon-alpha production (GO:0032727)2.30051275

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EGR1_19374776_ChIP-ChIP_THP-1_Human4.93749199
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.61974586
3IRF8_22096565_ChIP-ChIP_GC-B_Human4.22626681
4SCL_19346495_ChIP-Seq_HPC-7_Human3.81377978
5* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.74394915
6BP1_19119308_ChIP-ChIP_Hs578T_Human3.61306078
7* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.21794825
8TP63_17297297_ChIP-ChIP_HaCaT_Human3.19520181
9GATA1_22025678_ChIP-Seq_K562_Human2.83885118
10SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.79985494
11STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.75496498
12* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.69787221
13IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.69759577
14* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.69016528
15STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.52945005
16IRF8_21731497_ChIP-ChIP_J774_Mouse2.50436538
17RUNX_20019798_ChIP-Seq_JUKART_Human2.48162131
18IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.45621312
19IRF8_27001747_Chip-Seq_BMDM_Mouse2.37679632
20* NOTCH1_21737748_ChIP-Seq_TLL_Human2.37576066
21TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.37203104
22NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.30326463
23STAT4_19710469_ChIP-ChIP_TH1__Mouse2.28197229
24* GATA2_21666600_ChIP-Seq_HMVEC_Human2.25182413
25MYB_21317192_ChIP-Seq_ERMYB_Mouse2.23041719
26* GATA1_19941826_ChIP-Seq_K562_Human2.18874816
27SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.16981805
28FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.13910817
29TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse2.03634360
30CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.99020256
31ESR1_21235772_ChIP-Seq_MCF-7_Human1.98221896
32Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.95228307
33* TCF7_22412390_ChIP-Seq_EML_Mouse1.91990942
34* MAF_26560356_Chip-Seq_TH1_Human1.91757202
35* MYB_26560356_Chip-Seq_TH2_Human1.90394426
36CLOCK_20551151_ChIP-Seq_293T_Human1.89155411
37TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.84435331
38SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.83372815
39VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.83352673
40RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.75926751
41MYB_26560356_Chip-Seq_TH1_Human1.75084866
42MYC_22102868_ChIP-Seq_BL_Human1.73537116
43NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.71806913
44RUNX1_22412390_ChIP-Seq_EML_Mouse1.71571239
45VDR_24763502_ChIP-Seq_THP-1_Human1.64011567
46TRIM28_21343339_ChIP-Seq_HEK293_Human1.62737496
47BRD4_27068464_Chip-Seq_AML-cells_Mouse1.60734835
48STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.59684623
49* GATA2_19941826_ChIP-Seq_K562_Human1.56884262
50TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.56474678
51GATA1_19941827_ChIP-Seq_MEL_Mouse1.54678544
52SMAD_19615063_ChIP-ChIP_OVARY_Human1.49108997
53* ELK3_25401928_ChIP-Seq_HUVEC_Human1.47924576
54* SPI1_23547873_ChIP-Seq_NB4_Human1.47261635
55* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.45737406
56* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.45737406
57TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.44272460
58STAT6_21828071_ChIP-Seq_BEAS2B_Human1.42674807
59ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.40555496
60HIF1A_21447827_ChIP-Seq_MCF-7_Human1.40551717
61LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.38509321
62UTX_26944678_Chip-Seq_JUKART_Human1.38455464
63VDR_21846776_ChIP-Seq_THP-1_Human1.37078845
64* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.32278801
65SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.32118666
66LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.30714971
67MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.29995579
68VDR_24787735_ChIP-Seq_THP-1_Human1.29956535
69KDM2B_26808549_Chip-Seq_SUP-B15_Human1.29229037
70* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.27582448
71CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.26508316
72KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.26165148
73LXR_22292898_ChIP-Seq_THP-1_Human1.25675384
74PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.24867107
75KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.23574959
76* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.22345747
77* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.20667888
78KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.19722269
79THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.19110057
80KDM2B_26808549_Chip-Seq_JURKAT_Human1.16598623
81NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.16085923
82GATA3_27048872_Chip-Seq_THYMUS_Human1.15829089
83* GATA3_26560356_Chip-Seq_TH2_Human1.14794682
84PU_27001747_Chip-Seq_BMDM_Mouse1.14673190
85* NCOR1_26117541_ChIP-Seq_K562_Human1.14414805
86CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.14167446
87TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.13739623
88GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.12965125
89KDM2B_26808549_Chip-Seq_DND41_Human1.11730710
90FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.11334586
91PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.09756958
92PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.08726693
93SPI1_23127762_ChIP-Seq_K562_Human1.07092500
94RARG_19884340_ChIP-ChIP_MEFs_Mouse1.05035827
95* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.04673163
96CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.04624806
97HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.03727551
98SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.03204358
99PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.03083147
100CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.02584293
101CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.02088239
102BCL6_27268052_Chip-Seq_Bcells_Human1.01985604
103SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.01876934
104GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01866270
105ESR2_21235772_ChIP-Seq_MCF-7_Human1.00935650
106UBF1/2_26484160_Chip-Seq_HMECs_Human1.00849684
107WT1_19549856_ChIP-ChIP_CCG9911_Human1.00235659
108JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.99826745
109EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.99301060
110KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.98299693
111KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.98299693
112KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.98299693
113ELF1_20517297_ChIP-Seq_JURKAT_Human0.98127253
114FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.97461332
115* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.97198406
116KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.95666746
117CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.95636185
118* MAF_26560356_Chip-Seq_TH2_Human0.93461685
119FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.92786499

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to2.96269183
2MP0002877_abnormal_melanocyte_morpholog2.92772901
3MP0009278_abnormal_bone_marrow2.78888698
4MP0001835_abnormal_antigen_presentation2.71352152
5MP0002254_reproductive_system_inflammat2.65591159
6MP0001545_abnormal_hematopoietic_system2.47696619
7MP0005397_hematopoietic_system_phenotyp2.47696619
8MP0002009_preneoplasia2.42054641
9MP0000685_abnormal_immune_system2.41867787
10MP0005671_abnormal_response_to2.41668312
11MP0003436_decreased_susceptibility_to2.35223580
12MP0009785_altered_susceptibility_to2.17798476
13MP0005000_abnormal_immune_tolerance2.17650648
14MP0004147_increased_porphyrin_level2.15349001
15MP0003828_pulmonary_edema2.12863673
16MP0009840_abnormal_foam_cell2.10163188
17MP0005387_immune_system_phenotype2.08395928
18MP0001790_abnormal_immune_system2.08395928
19MP0002452_abnormal_antigen_presenting2.02766582
20MP0001800_abnormal_humoral_immune2.01781135
21MP0002148_abnormal_hypersensitivity_rea2.00303095
22MP0005058_abnormal_lysosome_morphology1.99107492
23MP0002166_altered_tumor_susceptibility1.98603475
24MP0006082_CNS_inflammation1.97258818
25MP0004808_abnormal_hematopoietic_stem1.96791912
26MP0005464_abnormal_platelet_physiology1.94619737
27MP0002419_abnormal_innate_immunity1.94282240
28MP0003763_abnormal_thymus_physiology1.91801547
29MP0002723_abnormal_immune_serum1.89907944
30MP0002405_respiratory_system_inflammati1.89696230
31MP0004510_myositis1.89063455
32MP0003300_gastrointestinal_ulcer1.85418779
33MP0002420_abnormal_adaptive_immunity1.82089541
34MP0004947_skin_inflammation1.81116178
35MP0001819_abnormal_immune_cell1.81110184
36MP0002138_abnormal_hepatobiliary_system1.78962103
37MP0008007_abnormal_cellular_replicative1.74160159
38MP0005025_abnormal_response_to1.72115586
39MP0002006_tumorigenesis1.71291224
40MP0002398_abnormal_bone_marrow1.68360402
41MP0003172_abnormal_lysosome_physiology1.65970799
42MP0009333_abnormal_splenocyte_physiolog1.65217596
43MP0002396_abnormal_hematopoietic_system1.62136311
44MP0010155_abnormal_intestine_physiology1.61764714
45MP0005310_abnormal_salivary_gland1.60240517
46MP0001853_heart_inflammation1.58423161
47MP0003303_peritoneal_inflammation1.58307304
48MP0001533_abnormal_skeleton_physiology1.56936128
49* MP0003656_abnormal_erythrocyte_physiolo1.54449073
50MP0001873_stomach_inflammation1.51846872
51MP0000716_abnormal_immune_system1.43074694
52MP0003191_abnormal_cellular_cholesterol1.40830518
53MP0000858_altered_metastatic_potential1.35014042
54* MP0002722_abnormal_immune_system1.33624318
55MP0001845_abnormal_inflammatory_respons1.33514492
56MP0003448_altered_tumor_morphology1.32970499
57* MP0000689_abnormal_spleen_morphology1.32674562
58MP0008004_abnormal_stomach_pH1.31179208
59MP0001879_abnormal_lymphatic_vessel1.29372850
60* MP0002429_abnormal_blood_cell1.28582150
61MP0001851_eye_inflammation1.27588789
62MP0000767_abnormal_smooth_muscle1.26622712
63MP0002933_joint_inflammation1.26149409
64MP0010368_abnormal_lymphatic_system1.23526194
65MP0005023_abnormal_wound_healing1.23437384
66MP0003453_abnormal_keratinocyte_physiol1.23226085
67MP0000465_gastrointestinal_hemorrhage1.21107582
68MP0000703_abnormal_thymus_morphology1.20903193
69MP0002998_abnormal_bone_remodeling1.20150509
70MP0001501_abnormal_sleep_pattern1.18736199
71MP0000604_amyloidosis1.18126910
72MP0003943_abnormal_hepatobiliary_system1.17974173
73MP0000343_altered_response_to1.16656993
74MP0003279_aneurysm1.15067325
75MP0005390_skeleton_phenotype1.13710330
76MP0005166_decreased_susceptibility_to1.11092639
77MP0004883_abnormal_blood_vessel1.10600086
78MP0001542_abnormal_bone_strength1.07215595
79MP0002132_abnormal_respiratory_system1.07079283
80MP0005164_abnormal_response_to1.04191635
81MP0002332_abnormal_exercise_endurance1.03937004
82MP0010352_gastrointestinal_tract_polyps1.00314893
83MP0003566_abnormal_cell_adhesion0.99281496
84MP0008260_abnormal_autophagy0.98598182
85MP0010307_abnormal_tumor_latency0.98099483
86MP0002060_abnormal_skin_morphology0.95655083
87MP0000249_abnormal_blood_vessel0.93694533
88MP0006054_spinal_hemorrhage0.93392651
89MP0000490_abnormal_crypts_of0.92731132
90MP0009764_decreased_sensitivity_to0.92363039
91MP0003075_altered_response_to0.90749080
92MP0008469_abnormal_protein_level0.89587136
93MP0003795_abnormal_bone_structure0.89173269
94MP0005076_abnormal_cell_differentiation0.88487467
95MP0005451_abnormal_body_composition0.86917226
96MP0008995_early_reproductive_senescence0.85544940
97MP0005167_abnormal_blood-brain_barrier0.84540844
98MP0009765_abnormal_xenobiotic_induced0.83942335
99MP0002928_abnormal_bile_duct0.82281834
100MP0001191_abnormal_skin_condition0.81572993
101MP0003091_abnormal_cell_migration0.80772299
102MP0003045_fibrosis0.80092248
103MP0005165_increased_susceptibility_to0.77356019
104MP0003866_abnormal_defecation0.76068782
105MP0001243_abnormal_dermal_layer0.73751871
106MP0009931_abnormal_skin_appearance0.71022156
107MP0008438_abnormal_cutaneous_collagen0.70400314
108MP0003941_abnormal_skin_development0.70346287
109MP0002277_abnormal_respiratory_mucosa0.67774352
110MP0003329_amyloid_beta_deposits0.67146836
111MP0004264_abnormal_extraembryonic_tissu0.66784975
112MP0005075_abnormal_melanosome_morpholog0.66675481
113MP0009763_increased_sensitivity_to0.65971551
114MP0008961_abnormal_basal_metabolism0.62453189
115MP0001216_abnormal_epidermal_layer0.55788719
116MP0001663_abnormal_digestive_system0.55218173
117MP0003221_abnormal_cardiomyocyte_apopto0.54962854
118MP0000609_abnormal_liver_physiology0.53715052
119MP0002136_abnormal_kidney_physiology0.52522644
120MP0003690_abnormal_glial_cell0.49249712
121MP0002019_abnormal_tumor_incidence0.48214301

Predicted human phenotypes

RankGene SetZ-score
1Prostate neoplasm (HP:0100787)4.75514763
2Orchitis (HP:0100796)4.11422286
3Myositis (HP:0100614)4.10538508
4Abnormality of glycolipid metabolism (HP:0010969)4.09234963
5Abnormality of liposaccharide metabolism (HP:0010968)4.09234963
6Abnormality of glycosphingolipid metabolism (HP:0004343)4.09234963
7Retrobulbar optic neuritis (HP:0100654)4.07207172
8Optic neuritis (HP:0100653)4.07207172
9Eczematoid dermatitis (HP:0000976)3.54917651
10Dysostosis multiplex (HP:0000943)3.52217479
11Abnormality of the heme biosynthetic pathway (HP:0010472)3.37547651
12Recurrent abscess formation (HP:0002722)3.35853266
13Stomach cancer (HP:0012126)3.27974018
14Elevated erythrocyte sedimentation rate (HP:0003565)3.21401022
15Keratoconjunctivitis (HP:0001096)3.11304057
16Keratoconjunctivitis sicca (HP:0001097)3.09644302
17Petechiae (HP:0000967)2.95209823
18Recurrent bacterial skin infections (HP:0005406)2.93635405
19Prolonged bleeding time (HP:0003010)2.90602208
20Pustule (HP:0200039)2.86292775
21Amyloidosis (HP:0011034)2.85526337
22Epistaxis (HP:0000421)2.84101901
23IgG deficiency (HP:0004315)2.83209179
24Increased cerebral lipofuscin (HP:0011813)2.77788968
25Abnormality of the prostate (HP:0008775)2.76328154
26Arterial thrombosis (HP:0004420)2.72658289
27Pulmonary infiltrates (HP:0002113)2.72014497
28Recurrent fungal infections (HP:0002841)2.71507141
29Mediastinal lymphadenopathy (HP:0100721)2.71204402
30Hematochezia (HP:0002573)2.71144989
31Increased serum ferritin (HP:0003281)2.68625514
32Spontaneous hematomas (HP:0007420)2.65620834
33Gangrene (HP:0100758)2.64946798
34Vasculitis (HP:0002633)2.64682875
35Loss of speech (HP:0002371)2.60587286
36Distal lower limb muscle weakness (HP:0009053)2.59638009
37Polycythemia (HP:0001901)2.57057195
38Myocardial infarction (HP:0001658)2.52836636
39Chronic obstructive pulmonary disease (HP:0006510)2.50328630
40Obstructive lung disease (HP:0006536)2.50328630
41Poikilocytosis (HP:0004447)2.48580455
42Granulocytopenia (HP:0001913)2.45648701
43Leukocytosis (HP:0001974)2.43175499
44Abnormality of polysaccharide metabolism (HP:0011012)2.42161972
45Abnormality of glycosaminoglycan metabolism (HP:0004371)2.42161972
46Abnormality of mucopolysaccharide metabolism (HP:0011020)2.42161972
47Lip pit (HP:0100267)2.41536638
48Abnormality of T cell physiology (HP:0011840)2.41330122
49Autoimmune hemolytic anemia (HP:0001890)2.38891720
50Abnormal delayed hypersensitivity skin test (HP:0002963)2.38790409
51Aortic aneurysm (HP:0004942)2.37466824
52Impaired platelet aggregation (HP:0003540)2.36930715
53Abnormal platelet function (HP:0011869)2.36930715
54Gastrointestinal stroma tumor (HP:0100723)2.36493024
55Amaurosis fugax (HP:0100576)2.35931852
56Abnormality of the fingertips (HP:0001211)2.34941128
57Abnormality of iron homeostasis (HP:0011031)2.34284441
58Segmental peripheral demyelination/remyelination (HP:0003481)2.33955499
59Hypergammaglobulinemia (HP:0010702)2.32712183
60Joint swelling (HP:0001386)2.31566790
61Urticaria (HP:0001025)2.29961445
62Increased IgM level (HP:0003496)2.29635831
63Conical tooth (HP:0000698)2.29195789
64Increased neuronal autofluorescent lipopigment (HP:0002074)2.29159493
65Thrombocytosis (HP:0001894)2.26729521
66Colitis (HP:0002583)2.26427449
67Severe combined immunodeficiency (HP:0004430)2.25536819
68Autoimmune thrombocytopenia (HP:0001973)2.25372903
69Axonal loss (HP:0003447)2.23433218
70Urinary glycosaminoglycan excretion (HP:0003541)2.22973975
71Mucopolysacchariduria (HP:0008155)2.22973975
72Parakeratosis (HP:0001036)2.22021842
73Hemoptysis (HP:0002105)2.21730305
74Abnormality of T cell number (HP:0011839)2.20591747
75Inflammation of the large intestine (HP:0002037)2.20521897
76Osteomalacia (HP:0002749)2.19526381
77Aortic valve stenosis (HP:0001650)2.18577767
78Recurrent cutaneous fungal infections (HP:0011370)2.17294906
79Chronic mucocutaneous candidiasis (HP:0002728)2.17294906
80Episodic fever (HP:0001954)2.16385913
81Eosinophilia (HP:0001880)2.15376152
82Abnormality of the distal phalanges of the toes (HP:0010182)2.14714900
83Vertebral compression fractures (HP:0002953)2.14565809
84Pulmonary artery stenosis (HP:0004415)2.14472409
85Chest pain (HP:0100749)2.14221537
86Recurrent viral infections (HP:0004429)2.10954827
87Restrictive lung disease (HP:0002091)2.10909259
88Recurrent gram-negative bacterial infections (HP:0005420)2.10732771
89Cellulitis (HP:0100658)2.09782217
90Anorexia (HP:0002039)2.09056712
91Recurrent skin infections (HP:0001581)2.08835191
92T lymphocytopenia (HP:0005403)2.08443339
93Polyneuropathy (HP:0001271)2.08189846
94Fatigue (HP:0012378)2.07069415
95Spondylolisthesis (HP:0003302)2.06245124
96Osteolytic defects of the phalanges of the hand (HP:0009771)2.04558153
97Osteolytic defects of the hand bones (HP:0009699)2.04558153
98Hypertensive crisis (HP:0100735)2.03966604
99Panhypogammaglobulinemia (HP:0003139)2.03817187
100Abnormality of the pleura (HP:0002103)2.03327341
101Systemic lupus erythematosus (HP:0002725)2.02817975
102Syringomyelia (HP:0003396)2.02299851
103Spinal cord lesions (HP:0100561)2.02299851
104Vertigo (HP:0002321)2.01328882
105Keratitis (HP:0000491)2.01142089
106Growth hormone excess (HP:0000845)2.00577794
107Anhidrosis (HP:0000970)1.99507405
108Acute myeloid leukemia (HP:0004808)1.98848624
109Vascular tortuosity (HP:0004948)1.98062484
110Abnormality of the pericardium (HP:0001697)1.98002088
111Gastrointestinal inflammation (HP:0004386)1.97785909
112Gingival bleeding (HP:0000225)1.95278310
113Verrucae (HP:0200043)1.94815502
114Interstitial pulmonary disease (HP:0006530)1.92648391
115IgM deficiency (HP:0002850)1.92039297
116Abnormality of eosinophils (HP:0001879)1.91870479
117Microcytic anemia (HP:0001935)1.91755162
118Abnormality of the nasal mucosa (HP:0000433)1.91147729
119Emphysema (HP:0002097)1.86967404
120Meningitis (HP:0001287)1.86750249
121Recurrent bronchitis (HP:0002837)1.86558534
122Thyroiditis (HP:0100646)1.86328955
123Diaphragmatic weakness (HP:0009113)1.85294325
124Nonimmune hydrops fetalis (HP:0001790)1.83170274
125Alveolar cell carcinoma (HP:0006519)1.82299232
126Bruising susceptibility (HP:0000978)1.80716521
127Abnormality of male internal genitalia (HP:0000022)1.79203064
128Increased IgE level (HP:0003212)1.78840886
129Osteomyelitis (HP:0002754)1.77593807
130Abnormality of T cells (HP:0002843)1.77556853
131Thick nail (HP:0001805)1.77132020
132Broad face (HP:0000283)1.76937465
133Chronic diarrhea (HP:0002028)1.76173239
134Arthralgia (HP:0002829)1.74409418
135Encephalitis (HP:0002383)1.73836861
136Abnormality of macrophages (HP:0004311)1.73773734
137IgA deficiency (HP:0002720)1.73326849
138Glomerulopathy (HP:0100820)1.72615708
139Stomatitis (HP:0010280)1.71801101
140Gastrointestinal infarctions (HP:0005244)1.69844013
141Alopecia of scalp (HP:0002293)1.68713296
142Lymphoma (HP:0002665)1.68300555
143Agammaglobulinemia (HP:0004432)1.67787398
144Vacuolated lymphocytes (HP:0001922)1.66728803
145Arterial tortuosity (HP:0005116)1.66035526
146Periodontitis (HP:0000704)1.66035489

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K144.00532932
2TGFBR23.42917987
3MAPK153.15855187
4IKBKB2.76220407
5IKBKE2.64642893
6TIE12.58817685
7CHUK2.40512319
8MAPKAPK32.37520077
9GRK62.36544720
10TBK12.34082512
11PRPF4B2.33378602
12RIPK42.23939122
13IRAK32.22327242
14TXK2.18124254
15EEF2K2.14059270
16JAK32.09101744
17TESK22.05869809
18PIK3CG1.96961976
19PIM21.92592026
20MAP4K11.90351722
21IRAK41.82570216
22MAP3K31.81517694
23NLK1.81335201
24TYK21.80319536
25STK101.75614368
26FES1.72214302
27TAOK21.65278294
28SIK31.64720428
29BLK1.63664473
30TRPM71.62814953
31MAP2K31.60547822
32EPHA31.58326856
33PIM11.57536621
34MAP3K131.57421259
35MAPKAPK51.57069695
36KIT1.48034992
37TSSK61.46689342
38JAK11.45907058
39ZAK1.41686487
40TEC1.36121427
41GRK71.33111566
42MAP2K21.31140336
43RPS6KB21.30433750
44MAP3K111.30244549
45ZAP701.29318308
46VRK11.28927243
47SIK21.14194301
48ERN11.12992309
49TAOK31.07996182
50MST41.07499806
51TGFBR11.07041341
52MAPKAPK21.04591774
53ITK1.01193819
54FGFR40.99605818
55EPHB10.98807507
56RPS6KA40.96107834
57EPHA20.95572306
58CLK10.93010974
59KDR0.92293414
60CDK120.91815162
61MAP3K100.90116588
62FLT30.89431336
63BTK0.88166774
64HIPK20.86034447
65RIPK10.85891011
66MAP3K10.84968029
67IRAK20.84953939
68MAPK70.82143236
69MAPK40.81425680
70RPS6KA50.81324824
71FGFR30.78996967
72EIF2AK20.78837291
73STK40.76569405
74JAK20.75923194
75PRKD20.75563856
76SIK10.75024854
77CDK80.74920983
78FGR0.73755061
79DYRK30.73146017
80RPS6KA60.72996695
81MOS0.72762036
82BMPR20.71641860
83LCK0.70522521
84CDK90.69195438
85SYK0.66810325
86CDC42BPA0.64316461
87CSK0.63807633
88MAP3K50.61858633
89RPS6KC10.61472614
90RPS6KL10.61472614
91STK240.61185650
92CSF1R0.59330714
93ADRBK20.59239316
94BRD40.58454115
95NEK90.58204134
96RPS6KA20.57161773
97MARK20.56323343
98CDK60.54300932
99HCK0.53757769
100TNK20.50931813
101BMPR1B0.50269623
102SGK20.49868152
103DDR20.49184073
104MKNK20.48238178
105MAPK120.47826339
106PRKAA20.46246137
107ABL20.45844226
108CDK30.45805356
109LYN0.45186724
110ARAF0.44208681
111SGK30.43524233
112PRKG20.43388838
113MATK0.43102559
114MARK30.41768509
115DYRK1B0.40944976
116GSK3A0.40564681
117MAPK30.40063104
118PDK10.39685207
119IRAK10.39281027
120CDK40.38179566
121BMX0.37737854
122MAPK110.37550332
123MAP3K70.35000028
124STK30.34818261
125RPS6KA10.34629676
126NME20.34534727
127PDGFRB0.33974055
128ABL10.32604185
129MAP2K10.32586048
130INSRR0.32225177
131MAPK10.29891695
132TAOK10.29515138
133MUSK0.29416002
134MAP3K60.28023229
135INSR0.27573640
136PRKCQ0.27031285

Predicted pathways (KEGG)

RankGene SetZ-score
1NF-kappa B signaling pathway_Homo sapiens_hsa040642.68585721
2Leishmaniasis_Homo sapiens_hsa051402.64021838
3Osteoclast differentiation_Homo sapiens_hsa043802.30039864
4Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.26669683
5TNF signaling pathway_Homo sapiens_hsa046682.07837512
6Measles_Homo sapiens_hsa051622.04571484
7NOD-like receptor signaling pathway_Homo sapiens_hsa046212.04368917
8Graft-versus-host disease_Homo sapiens_hsa053321.98274055
9Toll-like receptor signaling pathway_Homo sapiens_hsa046201.94991541
10Malaria_Homo sapiens_hsa051441.89612842
11Legionellosis_Homo sapiens_hsa051341.86207542
12Toxoplasmosis_Homo sapiens_hsa051451.84083881
13Antigen processing and presentation_Homo sapiens_hsa046121.82382455
14Intestinal immune network for IgA production_Homo sapiens_hsa046721.80610691
15Hematopoietic cell lineage_Homo sapiens_hsa046401.77648177
16Apoptosis_Homo sapiens_hsa042101.77028423
17RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.74458106
18Jak-STAT signaling pathway_Homo sapiens_hsa046301.71926478
19B cell receptor signaling pathway_Homo sapiens_hsa046621.64232199
20Influenza A_Homo sapiens_hsa051641.60879933
21Primary immunodeficiency_Homo sapiens_hsa053401.57371693
22Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.54266006
23Allograft rejection_Homo sapiens_hsa053301.49718570
24Pertussis_Homo sapiens_hsa051331.48309783
25Herpes simplex infection_Homo sapiens_hsa051681.45477294
26AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.43066195
27Hepatitis B_Homo sapiens_hsa051611.41949790
28Transcriptional misregulation in cancer_Homo sapiens_hsa052021.38071672
29Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.36911189
30Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.36111891
31Chronic myeloid leukemia_Homo sapiens_hsa052201.35918074
32Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.34393544
33T cell receptor signaling pathway_Homo sapiens_hsa046601.29847473
34Acute myeloid leukemia_Homo sapiens_hsa052211.29498862
35Glycosaminoglycan degradation_Homo sapiens_hsa005311.22837535
36Rheumatoid arthritis_Homo sapiens_hsa053231.22255049
37Small cell lung cancer_Homo sapiens_hsa052221.22236503
38Prolactin signaling pathway_Homo sapiens_hsa049171.19269505
39Hepatitis C_Homo sapiens_hsa051601.16637370
40Leukocyte transendothelial migration_Homo sapiens_hsa046701.09203597
41Shigellosis_Homo sapiens_hsa051311.07423430
42Other glycan degradation_Homo sapiens_hsa005111.05539047
43African trypanosomiasis_Homo sapiens_hsa051431.04690832
44Chemokine signaling pathway_Homo sapiens_hsa040621.04165665
45p53 signaling pathway_Homo sapiens_hsa041151.03865011
46Tuberculosis_Homo sapiens_hsa051521.02342042
47HTLV-I infection_Homo sapiens_hsa051661.01150603
48Staphylococcus aureus infection_Homo sapiens_hsa051501.00905031
49Prostate cancer_Homo sapiens_hsa052151.00618561
50Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.96992530
51Salmonella infection_Homo sapiens_hsa051320.96618372
52Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.96293847
53FoxO signaling pathway_Homo sapiens_hsa040680.92601327
54Platelet activation_Homo sapiens_hsa046110.91966559
55Notch signaling pathway_Homo sapiens_hsa043300.90170021
56Asthma_Homo sapiens_hsa053100.88383210
57Viral carcinogenesis_Homo sapiens_hsa052030.86626906
58Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.86357700
59Epstein-Barr virus infection_Homo sapiens_hsa051690.86291767
60Bladder cancer_Homo sapiens_hsa052190.85857971
61Pancreatic cancer_Homo sapiens_hsa052120.85269028
62Autoimmune thyroid disease_Homo sapiens_hsa053200.74959827
63Phagosome_Homo sapiens_hsa041450.74217782
64VEGF signaling pathway_Homo sapiens_hsa043700.74188420
65Amoebiasis_Homo sapiens_hsa051460.72404373
66ECM-receptor interaction_Homo sapiens_hsa045120.68911856
67MicroRNAs in cancer_Homo sapiens_hsa052060.67898957
68Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.67701188
69Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.66969281
70Neurotrophin signaling pathway_Homo sapiens_hsa047220.66605660
71SNARE interactions in vesicular transport_Homo sapiens_hsa041300.64775015
72Prion diseases_Homo sapiens_hsa050200.63975867
73Type I diabetes mellitus_Homo sapiens_hsa049400.63193760
74Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.61635686
75Adherens junction_Homo sapiens_hsa045200.59532931
76Focal adhesion_Homo sapiens_hsa045100.59397770
77Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.58786525
78MAPK signaling pathway_Homo sapiens_hsa040100.58631860
79Colorectal cancer_Homo sapiens_hsa052100.58139172
80Lysosome_Homo sapiens_hsa041420.57034660
81Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.55913034
82Insulin resistance_Homo sapiens_hsa049310.54177698
83Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.53706364
84Endocytosis_Homo sapiens_hsa041440.53046310
85Pathways in cancer_Homo sapiens_hsa052000.52834106
86Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.52783961
87Systemic lupus erythematosus_Homo sapiens_hsa053220.52472492
88Viral myocarditis_Homo sapiens_hsa054160.51261477
89Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.49232022
90PI3K-Akt signaling pathway_Homo sapiens_hsa041510.48991481
91Sphingolipid signaling pathway_Homo sapiens_hsa040710.48574865
92Circadian rhythm_Homo sapiens_hsa047100.47675694
93Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.47409780
94Adipocytokine signaling pathway_Homo sapiens_hsa049200.46530156
95Thyroid cancer_Homo sapiens_hsa052160.46128146
96Type II diabetes mellitus_Homo sapiens_hsa049300.45732006
97Non-small cell lung cancer_Homo sapiens_hsa052230.45613150
98Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.45434145
99Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.44257037
100TGF-beta signaling pathway_Homo sapiens_hsa043500.44209067
101HIF-1 signaling pathway_Homo sapiens_hsa040660.44175957
102Proteoglycans in cancer_Homo sapiens_hsa052050.43116452
103mTOR signaling pathway_Homo sapiens_hsa041500.43114693
104Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.42688573
105Renal cell carcinoma_Homo sapiens_hsa052110.42628298
106Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.42626048
107Endometrial cancer_Homo sapiens_hsa052130.42160248
108RNA degradation_Homo sapiens_hsa030180.41429817
109Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.40725420
110Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.40075195
111ABC transporters_Homo sapiens_hsa020100.39321488
112Choline metabolism in cancer_Homo sapiens_hsa052310.38670963
113GnRH signaling pathway_Homo sapiens_hsa049120.37579220
114Phospholipase D signaling pathway_Homo sapiens_hsa040720.37227192
115Dorso-ventral axis formation_Homo sapiens_hsa043200.35387673
116Sphingolipid metabolism_Homo sapiens_hsa006000.34309509
117Phosphatidylinositol signaling system_Homo sapiens_hsa040700.25100044
118ErbB signaling pathway_Homo sapiens_hsa040120.23899201
119Inositol phosphate metabolism_Homo sapiens_hsa005620.23383362
120Longevity regulating pathway - mammal_Homo sapiens_hsa042110.23187746

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