PPP1R15B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein phosphatase I-interacting protein that promotes the dephosphorylation of eukaryotic translation initiation factor 2A to regulate translation under conditions of cellular stress. The transcribed messenger RNA contains two upstream open reading frames (ORFs) that repress translation of the main protein coding ORF under normal conditions, while the protein coding ORF is expressed at high levels in response to stress. Continual translation of the mRNA under conditions of eukaryotic translation initiation factor 2A inactivation is thought to create a feedback loop for reactivation of the gene during recovery from stress. In addition, it has been shown that this protein plays a role in membrane traffic that is independent of translation and that it is required for exocytosis from erythroleukemia cells. Allelic variants of this gene are associated with microcephaly, short stature, and impaired glucose metabolism. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1response to muramyl dipeptide (GO:0032495)4.07506450
2regulation of vitamin D biosynthetic process (GO:0060556)4.03588905
3response to peptidoglycan (GO:0032494)4.01276137
4embryonic process involved in female pregnancy (GO:0060136)3.70193814
5pore complex assembly (GO:0046931)3.67412667
6low-density lipoprotein particle clearance (GO:0034383)3.60165308
7alpha-linolenic acid metabolic process (GO:0036109)3.47489428
8antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.47473314
9antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.47473314
10regulation of cholesterol homeostasis (GO:2000188)3.39890009
11negative regulation of interleukin-12 production (GO:0032695)3.31572137
12intestinal cholesterol absorption (GO:0030299)3.30847400
13triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.30429592
14cysteine metabolic process (GO:0006534)3.22746565
15iron ion import (GO:0097286)3.19043230
16regulation of interferon-alpha production (GO:0032647)3.19012930
17Rap protein signal transduction (GO:0032486)3.18739562
18lipopolysaccharide-mediated signaling pathway (GO:0031663)3.16831909
19positive regulation of histone deacetylation (GO:0031065)3.14052015
20mitotic sister chromatid cohesion (GO:0007064)3.12816163
21negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.09283243
22negative regulation of cholesterol transport (GO:0032375)3.09076566
23negative regulation of sterol transport (GO:0032372)3.09076566
24urea cycle (GO:0000050)3.07934358
25urea metabolic process (GO:0019627)3.07934358
26regulation of vitamin metabolic process (GO:0030656)3.06487144
27regulation of interleukin-12 biosynthetic process (GO:0045075)3.05595564
28antigen processing and presentation of endogenous antigen (GO:0019883)3.05142835
29regulation of cholesterol storage (GO:0010885)3.05076400
30plasma lipoprotein particle clearance (GO:0034381)3.04656604
31necroptotic process (GO:0070266)3.04398039
32protein-lipid complex assembly (GO:0065005)3.03172887
33protein carboxylation (GO:0018214)3.02697207
34peptidyl-glutamic acid carboxylation (GO:0017187)3.02697207
35plasma lipoprotein particle assembly (GO:0034377)3.01031029
36positive regulation of interferon-alpha production (GO:0032727)2.98223493
37erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.98101106
38L-phenylalanine catabolic process (GO:0006559)2.98101106
39regulation of T-helper 1 cell differentiation (GO:0045625)2.92836681
40germinal center formation (GO:0002467)2.92031876
41positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.91206210
42regulation of histone H3-K27 methylation (GO:0061085)2.88243062
43nuclear pore complex assembly (GO:0051292)2.86959156
44NIK/NF-kappaB signaling (GO:0038061)2.86792936
45L-alpha-amino acid transmembrane transport (GO:1902475)2.85214502
46positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.82685679
47erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.82578246
48L-phenylalanine metabolic process (GO:0006558)2.82578246
49negative regulation of fibrinolysis (GO:0051918)2.82256827
50regulation of fatty acid beta-oxidation (GO:0031998)2.80417431
51positive regulation of fatty acid beta-oxidation (GO:0032000)2.80355726
52cellular response to arsenic-containing substance (GO:0071243)2.80172218
53complement activation, alternative pathway (GO:0006957)2.79861477
54macrophage activation involved in immune response (GO:0002281)2.79187872
55homocysteine metabolic process (GO:0050667)2.78586806
56regulation of gamma-delta T cell differentiation (GO:0045586)2.76055283
57sulfur amino acid catabolic process (GO:0000098)2.75881060
58intestinal absorption (GO:0050892)2.75627624
59CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.74041441
60T-helper 1 type immune response (GO:0042088)2.73425667
61detection of molecule of bacterial origin (GO:0032490)2.73141498
62regulation of interferon-beta biosynthetic process (GO:0045357)2.72776771
63pentose-phosphate shunt (GO:0006098)2.72707206
64high-density lipoprotein particle remodeling (GO:0034375)2.70042199
65mannose metabolic process (GO:0006013)2.69948751
66positive regulation of gamma-delta T cell activation (GO:0046645)2.69627780
67regulation of triglyceride catabolic process (GO:0010896)2.69555130
68lysine catabolic process (GO:0006554)2.69139243
69lysine metabolic process (GO:0006553)2.69139243
70nuclear pore organization (GO:0006999)2.68697932
71hepatocyte apoptotic process (GO:0097284)2.66869132
72phospholipid efflux (GO:0033700)2.66303845
73growth hormone receptor signaling pathway (GO:0060396)2.65776337
74negative regulation of fatty acid biosynthetic process (GO:0045717)2.65774777
75nitrogen cycle metabolic process (GO:0071941)2.65164942
76regulation of interleukin-8 biosynthetic process (GO:0045414)2.64560571
77positive regulation of lipid catabolic process (GO:0050996)2.64202330
78negative regulation of erythrocyte differentiation (GO:0045647)2.63598654
79positive regulation of interleukin-2 production (GO:0032743)2.63289847
80glycine metabolic process (GO:0006544)2.61806823
81cellular response to ethanol (GO:0071361)2.61716277
82neutrophil activation involved in immune response (GO:0002283)2.60671863
83positive regulation of type 2 immune response (GO:0002830)2.60595574
84phospholipid homeostasis (GO:0055091)2.60553918
85response to protozoan (GO:0001562)2.59508179
86folic acid-containing compound biosynthetic process (GO:0009396)2.59280328
87regulation of RNA export from nucleus (GO:0046831)2.58691939
88regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.57962916
89cellular extravasation (GO:0045123)2.56940699
90cytoplasmic mRNA processing body assembly (GO:0033962)2.56683317
91regulation of protein activation cascade (GO:2000257)2.55934176
92regulation of chronic inflammatory response (GO:0002676)2.55458125
93reverse cholesterol transport (GO:0043691)2.55261388
94negative regulation of lipid transport (GO:0032369)2.54647466
95aromatic amino acid family catabolic process (GO:0009074)2.53336755
96NADPH regeneration (GO:0006740)2.52868568
97regulation of translational fidelity (GO:0006450)2.52860296
98positive regulation of interferon-beta production (GO:0032728)2.52624097
99establishment of endothelial barrier (GO:0061028)2.51775862
100positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.51209398
101regulation of translation in response to stress (GO:0043555)2.50628341
102type I interferon signaling pathway (GO:0060337)2.50627543
103cellular response to type I interferon (GO:0071357)2.50627543
104regulation of gamma-delta T cell activation (GO:0046643)2.50412658
105fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.49352432
106regulation of centriole replication (GO:0046599)2.48602764
107response to type I interferon (GO:0034340)2.48053953
108histone demethylation (GO:0016577)2.47731435
109defense response to protozoan (GO:0042832)2.47435693
110very-low-density lipoprotein particle assembly (GO:0034379)2.46844410
111kynurenine metabolic process (GO:0070189)2.46518019
112valine metabolic process (GO:0006573)2.46365478
113CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.45273763
114T-helper cell differentiation (GO:0042093)2.45273763
115positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.44742452
116regulation of complement activation (GO:0030449)2.44674838
117nucleotide-binding oligomerization domain containing signaling pathway (GO:0070423)2.44648391
118positive regulation of keratinocyte differentiation (GO:0045618)2.44410832
119positive regulation by organism of defense response of other organism involved in symbiotic interact2.44175239
120modulation by symbiont of host immune response (GO:0052553)2.44175239
121positive regulation by symbiont of host defense response (GO:0052509)2.44175239
122modulation by symbiont of host defense response (GO:0052031)2.44175239
123modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.44175239
124modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.44175239
125regulation of nucleobase-containing compound transport (GO:0032239)2.43123712
126regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.43042219
127regulation of response to interferon-gamma (GO:0060330)2.42759715
1283-UTR-mediated mRNA stabilization (GO:0070935)2.42406105
129lipoprotein metabolic process (GO:0042157)2.42169833
130positive regulation of nitric oxide biosynthetic process (GO:0045429)2.41850884
131apoptotic cell clearance (GO:0043277)2.41571923
132protein localization to endosome (GO:0036010)2.39931310
133regulation of immunoglobulin secretion (GO:0051023)2.39610874
134response to laminar fluid shear stress (GO:0034616)2.39443357
135histone lysine demethylation (GO:0070076)2.39335688
136JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.39324065
137regulation of type I interferon-mediated signaling pathway (GO:0060338)2.39218133
138programmed necrotic cell death (GO:0097300)2.39188341
139detection of other organism (GO:0098543)2.39090848
140positive regulation of triglyceride metabolic process (GO:0090208)2.38905541
141leukocyte aggregation (GO:0070486)2.38599150
142trophectodermal cell differentiation (GO:0001829)2.38297182
143serine family amino acid biosynthetic process (GO:0009070)2.37722554
144positive regulation of heat generation (GO:0031652)2.37523152
145serine family amino acid catabolic process (GO:0009071)2.37449161
146serine family amino acid metabolic process (GO:0009069)2.36831225
147cytoplasmic pattern recognition receptor signaling pathway (GO:0002753)2.36690299
148tolerance induction (GO:0002507)2.36300957
149protein-lipid complex subunit organization (GO:0071825)2.36182688
150cholesterol efflux (GO:0033344)2.35334221
151sterol homeostasis (GO:0055092)2.34738245
152regulation of fever generation (GO:0031620)2.34427811
153cholesterol homeostasis (GO:0042632)2.34392259
154regulation of interleukin-12 production (GO:0032655)2.34085895
155regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.33795679
156plasma lipoprotein particle remodeling (GO:0034369)2.33089423
157protein-lipid complex remodeling (GO:0034368)2.33089423
158macromolecular complex remodeling (GO:0034367)2.33089423
159necrotic cell death (GO:0070265)2.33088010
160dosage compensation (GO:0007549)2.32832542
161bile acid biosynthetic process (GO:0006699)2.31683669
162regulation of fibrinolysis (GO:0051917)2.31308285
163plasma lipoprotein particle organization (GO:0071827)2.30380959
164tetrahydrofolate metabolic process (GO:0046653)2.30212780
165one-carbon metabolic process (GO:0006730)2.30168753
166regulation of T-helper cell differentiation (GO:0045622)2.30095758
167histone H3-K36 demethylation (GO:0070544)2.29553362
168regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.28650298
169ethanol oxidation (GO:0006069)2.28297811
170positive regulation of p38MAPK cascade (GO:1900745)2.27780407
171T cell lineage commitment (GO:0002360)2.26629286
172positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.25696700
173maternal placenta development (GO:0001893)2.24677192
174regulation of integrin activation (GO:0033623)2.24635788
175positive regulation of interleukin-12 production (GO:0032735)2.24426373
176positive regulation of interleukin-6 production (GO:0032755)2.24390854
177myeloid dendritic cell differentiation (GO:0043011)2.24022094
178positive regulation of lipid storage (GO:0010884)2.23717415
179negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.23640616
180antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.23484193
181acylglycerol homeostasis (GO:0055090)2.23358732
182triglyceride homeostasis (GO:0070328)2.23358732
183negative regulation of production of molecular mediator of immune response (GO:0002701)2.22782862
184positive regulation of triglyceride lipase activity (GO:0061365)2.22495513
185positive regulation of lipoprotein lipase activity (GO:0051006)2.22495513
186cellular response to growth hormone stimulus (GO:0071378)2.22310289

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.36508926
2E2F7_22180533_ChIP-Seq_HELA_Human4.22600943
3EGR1_19374776_ChIP-ChIP_THP-1_Human3.54289732
4NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.50524585
5* RXR_22158963_ChIP-Seq_LIVER_Mouse3.20248471
6* PPARA_22158963_ChIP-Seq_LIVER_Mouse3.14579593
7FOXM1_23109430_ChIP-Seq_U2OS_Human2.91199232
8FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.75339421
9* LXR_22158963_ChIP-Seq_LIVER_Mouse2.72432547
10MYC_22102868_ChIP-Seq_BL_Human2.56067126
11STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.54422619
12IRF8_22096565_ChIP-ChIP_GC-B_Human2.50674351
13BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.37419188
14PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.34689926
15NOTCH1_21737748_ChIP-Seq_TLL_Human2.27428422
16GATA1_22025678_ChIP-Seq_K562_Human2.15524691
17* CLOCK_20551151_ChIP-Seq_293T_Human2.08483507
18SMAD_19615063_ChIP-ChIP_OVARY_Human2.07856003
19EGR1_23403033_ChIP-Seq_LIVER_Mouse2.07087877
20FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.03873721
21* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.86025878
22STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.84441905
23TP63_17297297_ChIP-ChIP_HaCaT_Human1.83063168
24* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.82436782
25MYB_21317192_ChIP-Seq_ERMYB_Mouse1.80066158
26IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.74722496
27VDR_21846776_ChIP-Seq_THP-1_Human1.74620746
28* TCF7_22412390_ChIP-Seq_EML_Mouse1.72836123
29* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.68620715
30KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.66865119
31* CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.65554487
32ESR1_21235772_ChIP-Seq_MCF-7_Human1.62980364
33MAF_26560356_Chip-Seq_TH1_Human1.62737785
34FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.62262457
35KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.61435560
36* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.60472910
37NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.59614957
38* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.57759099
39SPI1_23547873_ChIP-Seq_NB4_Human1.56335018
40* IRF8_27001747_Chip-Seq_BMDM_Mouse1.54600920
41SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.53214234
42NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.52568264
43ZNF263_19887448_ChIP-Seq_K562_Human1.51348006
44* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.50395741
45AR_21909140_ChIP-Seq_LNCAP_Human1.49351901
46IRF8_21731497_ChIP-ChIP_J774_Mouse1.44820366
47SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.44176147
48SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.44176147
49* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.42975803
50* ELK3_25401928_ChIP-Seq_HUVEC_Human1.42830625
51* UTX_26944678_Chip-Seq_JUKART_Human1.42608380
52MYB_26560356_Chip-Seq_TH1_Human1.42504045
53* KDM2B_26808549_Chip-Seq_DND41_Human1.42074034
54* NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.42033357
55* MYB_26560356_Chip-Seq_TH2_Human1.41128049
56STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.40983310
57ESR2_21235772_ChIP-Seq_MCF-7_Human1.40963799
58ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.40804387
59* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.39291882
60PKCTHETA_26484144_Chip-Seq_BREAST_Human1.37876919
61* FOXO3_23340844_ChIP-Seq_DLD1_Human1.35624639
62GATA6_25053715_ChIP-Seq_YYC3_Human1.34106284
63TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.33993229
64KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.32437490
65SOX2_27498859_Chip-Seq_STOMACH_Mouse1.30549155
66SCL_19346495_ChIP-Seq_HPC-7_Human1.29241368
67CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.28620374
68VDR_24787735_ChIP-Seq_THP-1_Human1.28042980
69* CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.27353461
70CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.27277482
71* IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.26699010
72STAT3_1855785_ChIP-Seq_MESCs_Mouse1.26596075
73VDR_24763502_ChIP-Seq_THP-1_Human1.26404362
74KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.25538503
75HIF1A_21447827_ChIP-Seq_MCF-7_Human1.25381102
76* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.24931898
77FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.24821989
78SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.24474509
79* ATF3_27146783_Chip-Seq_COLON_Human1.24040760
80* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.23254964
81GATA1_19941826_ChIP-Seq_K562_Human1.23127201
82* RUNX1_22412390_ChIP-Seq_EML_Mouse1.22791790
83NCOR1_26117541_ChIP-Seq_K562_Human1.21135578
84* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.20307872
85* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.19605551
86* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.18415449
87P300_27058665_Chip-Seq_ZR-75-30cells_Human1.16127950
88EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.15241370
89Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.15238878
90VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.14507688
91RUNX_20019798_ChIP-Seq_JUKART_Human1.14082753
92SALL1_21062744_ChIP-ChIP_HESCs_Human1.10185606
93* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.09706445
94E2F4_17652178_ChIP-ChIP_JURKAT_Human1.08818444
95SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.08014812
96FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.06981257
97* RACK7_27058665_Chip-Seq_MCF-7_Human1.06456675
98RUNX1_27514584_Chip-Seq_MCF-7_Human1.05005810
99* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.04063156
100ESR1_20079471_ChIP-ChIP_T-47D_Human1.04016349
101FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.02708809
102TFEB_21752829_ChIP-Seq_HELA_Human1.02321903
103* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.01990663
104* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.01100852
105TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.00282488
106* HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.00279183
107SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.00167038
108* UBF1/2_26484160_Chip-Seq_HMECs_Human0.99702309
109E2F1_21310950_ChIP-Seq_MCF-7_Human0.99154680
110ZNF217_24962896_ChIP-Seq_MCF-7_Human0.98140883
111KDM2B_26808549_Chip-Seq_JURKAT_Human0.97895394
112* GATA2_22383799_ChIP-Seq_G1ME_Mouse0.97219883
113PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.97064904
114PADI4_21655091_ChIP-ChIP_MCF-7_Human0.96823454
115* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.96821233
116MAF_26560356_Chip-Seq_TH2_Human0.96036132
117TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.95155610
118CHD1_26751641_Chip-Seq_LNCaP_Human0.95034048
119* GATA4_25053715_ChIP-Seq_YYC3_Human0.94187410
120FOXA2_19822575_ChIP-Seq_HepG2_Human0.94007409
121* PU_27001747_Chip-Seq_BMDM_Mouse0.91661748
122POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.90537993
123* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.90448677
124PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.89625828
125GATA3_27048872_Chip-Seq_THYMUS_Human0.89413072
126PPAR_26484153_Chip-Seq_NCI-H1993_Human0.88971256
127* GATA2_19941826_ChIP-Seq_K562_Human0.88640871
128SALL4_18804426_ChIP-ChIP_XEN_Mouse0.88221051

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002009_preneoplasia3.92768451
2MP0005360_urolithiasis3.75780080
3MP0002139_abnormal_hepatobiliary_system3.51911363
4MP0003705_abnormal_hypodermis_morpholog3.14480863
5MP0008057_abnormal_DNA_replication3.07750585
6MP0003724_increased_susceptibility_to2.66015263
7MP0003300_gastrointestinal_ulcer2.64507829
8MP0005365_abnormal_bile_salt2.63275528
9MP0005085_abnormal_gallbladder_physiolo2.53520404
10MP0010352_gastrointestinal_tract_polyps2.49625145
11MP0009840_abnormal_foam_cell2.45992958
12MP0003303_peritoneal_inflammation2.32498331
13MP0010234_abnormal_vibrissa_follicle2.19235369
14MP0003252_abnormal_bile_duct2.08533149
15MP0005076_abnormal_cell_differentiation2.05352624
16MP0005451_abnormal_body_composition1.93385433
17MP0010307_abnormal_tumor_latency1.89458559
18MP0001666_abnormal_nutrient_absorption1.88976961
19MP0005083_abnormal_biliary_tract1.88089388
20MP0002148_abnormal_hypersensitivity_rea1.86002017
21MP0010329_abnormal_lipoprotein_level1.84775405
22MP0003806_abnormal_nucleotide_metabolis1.82360032
23MP0003191_abnormal_cellular_cholesterol1.76987913
24MP0003436_decreased_susceptibility_to1.74943550
25MP0008875_abnormal_xenobiotic_pharmacok1.73750408
26MP0000609_abnormal_liver_physiology1.68400295
27MP0009278_abnormal_bone_marrow1.65378640
28MP0004947_skin_inflammation1.57638318
29MP0003656_abnormal_erythrocyte_physiolo1.53937816
30MP0004185_abnormal_adipocyte_glucose1.53830165
31MP0003828_pulmonary_edema1.50464776
32MP0003566_abnormal_cell_adhesion1.48854283
33MP0005671_abnormal_response_to1.42142947
34MP0000685_abnormal_immune_system1.39318513
35MP0002166_altered_tumor_susceptibility1.38699925
36MP0003453_abnormal_keratinocyte_physiol1.38078894
37MP0005023_abnormal_wound_healing1.33102306
38MP0009764_decreased_sensitivity_to1.31775706
39MP0005310_abnormal_salivary_gland1.29864887
40MP0008004_abnormal_stomach_pH1.29349185
41MP0001800_abnormal_humoral_immune1.28185814
42MP0002877_abnormal_melanocyte_morpholog1.27879191
43MP0005464_abnormal_platelet_physiology1.24599897
44MP0006054_spinal_hemorrhage1.22840569
45MP0005397_hematopoietic_system_phenotyp1.22297502
46MP0001545_abnormal_hematopoietic_system1.22297502
47MP0002138_abnormal_hepatobiliary_system1.21086613
48MP0002332_abnormal_exercise_endurance1.19958300
49MP0001835_abnormal_antigen_presentation1.17729741
50MP0010155_abnormal_intestine_physiology1.17417313
51MP0005387_immune_system_phenotype1.16077829
52MP0001790_abnormal_immune_system1.16077829
53MP0001851_eye_inflammation1.16060234
54MP0003221_abnormal_cardiomyocyte_apopto1.13765439
55MP0000703_abnormal_thymus_morphology1.13167319
56MP0006082_CNS_inflammation1.12945566
57MP0004264_abnormal_extraembryonic_tissu1.12109841
58MP0004510_myositis1.10452950
59MP0002452_abnormal_antigen_presenting1.09971228
60MP0003077_abnormal_cell_cycle1.09913283
61* MP0000598_abnormal_liver_morphology1.08845789
62MP0002998_abnormal_bone_remodeling1.08638821
63MP0005058_abnormal_lysosome_morphology1.07890371
64MP0005666_abnormal_adipose_tissue1.07621952
65MP0010094_abnormal_chromosome_stability1.07103164
66MP0002419_abnormal_innate_immunity1.06663670
67MP0001873_stomach_inflammation1.06292997
68MP0002118_abnormal_lipid_homeostasis1.06158638
69MP0008438_abnormal_cutaneous_collagen1.04875208
70MP0004233_abnormal_muscle_weight1.03575483
71MP0005647_abnormal_sex_gland1.02867631
72MP0002006_tumorigenesis1.01460991
73MP0005025_abnormal_response_to1.01380429
74MP0005319_abnormal_enzyme/_coenzyme0.99877837
75MP0001845_abnormal_inflammatory_respons0.99279835
76MP0005000_abnormal_immune_tolerance0.99154035
77MP0002398_abnormal_bone_marrow0.97518432
78MP0002723_abnormal_immune_serum0.97391478
79MP0002405_respiratory_system_inflammati0.95946318
80MP0004808_abnormal_hematopoietic_stem0.94962833
81MP0009785_altered_susceptibility_to0.93612360
82MP0003448_altered_tumor_morphology0.92944376
83MP0001533_abnormal_skeleton_physiology0.92257853
84MP0008961_abnormal_basal_metabolism0.92184815
85MP0008469_abnormal_protein_level0.92041015
86MP0002420_abnormal_adaptive_immunity0.91232154
87MP0001819_abnormal_immune_cell0.90804624
88MP0001849_ear_inflammation0.90720986
89MP0009763_increased_sensitivity_to0.90641864
90MP0001915_intracranial_hemorrhage0.90539842
91MP0005332_abnormal_amino_acid0.90354430
92MP0001216_abnormal_epidermal_layer0.90100053
93MP0005621_abnormal_cell_physiology0.89823279
94MP0002086_abnormal_extraembryonic_tissu0.89044362
95MP0000689_abnormal_spleen_morphology0.89007565
96MP0003091_abnormal_cell_migration0.87682563
97MP0004197_abnormal_fetal_growth/weight/0.87421870
98MP0000465_gastrointestinal_hemorrhage0.87325737
99MP0000490_abnormal_crypts_of0.86948473
100MP0002722_abnormal_immune_system0.86408109
101MP0009643_abnormal_urine_homeostasis0.84707451
102MP0001730_embryonic_growth_arrest0.84153022
103MP0009115_abnormal_fat_cell0.83569302
104MP0002796_impaired_skin_barrier0.83051521
105MP0000716_abnormal_immune_system0.82796646
106MP0001853_heart_inflammation0.82279091
107MP0010678_abnormal_skin_adnexa0.81879718
108MP0003111_abnormal_nucleus_morphology0.81096068
109MP0003868_abnormal_feces_composition0.80712008
110MP0009333_abnormal_splenocyte_physiolog0.80592698
111MP0009053_abnormal_anal_canal0.80529119
112MP0005375_adipose_tissue_phenotype0.79902737
113MP0005164_abnormal_response_to0.79206055
114MP0002396_abnormal_hematopoietic_system0.79189964
115MP0000604_amyloidosis0.78790544
116* MP0002429_abnormal_blood_cell0.77007745
117MP0002019_abnormal_tumor_incidence0.76945435
118MP0000858_altered_metastatic_potential0.76827194
119MP0003075_altered_response_to0.76491895
120MP0002971_abnormal_brown_adipose0.76251234
121MP0002254_reproductive_system_inflammat0.75930332
122MP0000733_abnormal_muscle_development0.75582368
123MP0002060_abnormal_skin_morphology0.75495339
124MP0003795_abnormal_bone_structure0.74501169
125MP0003763_abnormal_thymus_physiology0.74396189
126MP0002088_abnormal_embryonic_growth/wei0.73968685
127MP0000350_abnormal_cell_proliferation0.73084175
128MP0005408_hypopigmentation0.72876456
129MP0003984_embryonic_growth_retardation0.72815736
130MP0003943_abnormal_hepatobiliary_system0.69408856
131MP0001727_abnormal_embryo_implantation0.68831740
132MP0004782_abnormal_surfactant_physiolog0.67484307
133MP0008007_abnormal_cellular_replicative0.65492450

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)3.84378690
2Xanthomatosis (HP:0000991)3.48046817
3Stomatitis (HP:0010280)3.39852998
4Retrobulbar optic neuritis (HP:0100654)3.36021441
5Optic neuritis (HP:0100653)3.36021441
6Myocardial infarction (HP:0001658)3.30819759
7Intrahepatic cholestasis (HP:0001406)3.27074909
8Abnormality of monocarboxylic acid metabolism (HP:0010996)3.16106009
9Orchitis (HP:0100796)3.14719394
10Hypobetalipoproteinemia (HP:0003563)2.93154730
11Acanthocytosis (HP:0001927)2.90607965
12Abnormality of the nasal septum (HP:0000419)2.88476153
13Spastic diplegia (HP:0001264)2.82097628
14Sparse lateral eyebrow (HP:0005338)2.77701945
15Complement deficiency (HP:0004431)2.76343143
16Deep philtrum (HP:0002002)2.74367611
17Recurrent abscess formation (HP:0002722)2.73215819
18Myositis (HP:0100614)2.68097678
19Abnormality of the common coagulation pathway (HP:0010990)2.67527835
20Autoimmune hemolytic anemia (HP:0001890)2.63003100
21Abnormality of glutamine family amino acid metabolism (HP:0010902)2.58726043
22Absent frontal sinuses (HP:0002688)2.58354516
23Increased mean platelet volume (HP:0011877)2.58320559
24Fatigue (HP:0012378)2.55131202
25Recurrent gram-negative bacterial infections (HP:0005420)2.54899094
26Poikilocytosis (HP:0004447)2.54114764
27Epidermoid cyst (HP:0200040)2.53870213
28Abnormality of macrophages (HP:0004311)2.53532361
29Abnormality of sulfur amino acid metabolism (HP:0004339)2.52960944
30Abnormal platelet volume (HP:0011876)2.52491968
31Esophageal varix (HP:0002040)2.52174767
32Autoimmune thrombocytopenia (HP:0001973)2.51433572
33Mediastinal lymphadenopathy (HP:0100721)2.51347643
34Spinal cord lesions (HP:0100561)2.50611311
35Syringomyelia (HP:0003396)2.50611311
36Eczematoid dermatitis (HP:0000976)2.49982569
37Keratoconjunctivitis sicca (HP:0001097)2.48432819
38Acute myeloid leukemia (HP:0004808)2.48232402
39Osteolytic defects of the hand bones (HP:0009699)2.47849482
40Osteolytic defects of the phalanges of the hand (HP:0009771)2.47849482
41Asymmetry of the thorax (HP:0001555)2.47324414
42Abnormality of aromatic amino acid family metabolism (HP:0004338)2.39027201
43Hypolipoproteinemia (HP:0010981)2.38206229
44Cutaneous melanoma (HP:0012056)2.37762678
45Curly hair (HP:0002212)2.34316120
46Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.34177852
47Abnormality of complement system (HP:0005339)2.32886448
48Cerebral aneurysm (HP:0004944)2.31127166
49Ulnar bowing (HP:0003031)2.29914011
50Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.26854011
51Hyperlipoproteinemia (HP:0010980)2.25549584
52Reticulocytosis (HP:0001923)2.25387638
53Hepatocellular carcinoma (HP:0001402)2.24839651
54Hematochezia (HP:0002573)2.24115278
55Keratoconjunctivitis (HP:0001096)2.23683409
56Recurrent viral infections (HP:0004429)2.22038433
57Viral hepatitis (HP:0006562)2.20011441
58Loss of speech (HP:0002371)2.19126848
59Thickened calvaria (HP:0002684)2.18336520
60Pseudobulbar signs (HP:0002200)2.17554942
61Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.17486789
62Hypoalphalipoproteinemia (HP:0003233)2.17200582
63Dysmetric saccades (HP:0000641)2.17040862
64Hypochromic microcytic anemia (HP:0004840)2.16872689
65Gingival bleeding (HP:0000225)2.16392714
66Polycythemia (HP:0001901)2.15440428
67Prominent nose (HP:0000448)2.15353440
68IgA deficiency (HP:0002720)2.14847055
69Slow saccadic eye movements (HP:0000514)2.13362449
70Arterial thrombosis (HP:0004420)2.13350326
71Relative macrocephaly (HP:0004482)2.13080047
72Micronodular cirrhosis (HP:0001413)2.12973154
73Joint hemorrhage (HP:0005261)2.12548777
74Pustule (HP:0200039)2.12476937
75Vasculitis (HP:0002633)2.12280712
76Abnormality of liposaccharide metabolism (HP:0010968)2.11901158
77Abnormality of glycosphingolipid metabolism (HP:0004343)2.11901158
78Abnormality of glycolipid metabolism (HP:0010969)2.11901158
79Peritonitis (HP:0002586)2.11239891
80Hepatitis (HP:0012115)2.11009293
81Subacute progressive viral hepatitis (HP:0006572)2.10152460
82Entropion (HP:0000621)2.08780864
83Hemorrhage of the eye (HP:0011885)2.07070016
84Hypercholesterolemia (HP:0003124)2.05422601
85Ectropion (HP:0000656)2.04811953
86Heterotopia (HP:0002282)2.02760268
87Fat malabsorption (HP:0002630)1.99548055
88Systemic lupus erythematosus (HP:0002725)1.99497903
89Cellulitis (HP:0100658)1.95268854
90Tetraparesis (HP:0002273)1.94649390
91Short chin (HP:0000331)1.92387608
92Blepharitis (HP:0000498)1.92028897
93Spontaneous hematomas (HP:0007420)1.90869616
94Back pain (HP:0003418)1.90698584
95Mitral valve prolapse (HP:0001634)1.90664068
96Recurrent fungal infections (HP:0002841)1.89897118
97Abnormality of proline metabolism (HP:0010907)1.89562307
98Hydroxyprolinuria (HP:0003080)1.89562307
99T lymphocytopenia (HP:0005403)1.89413796
100Prolonged partial thromboplastin time (HP:0003645)1.89055050
101Cortical dysplasia (HP:0002539)1.89017895
102Abnormality of the frontal sinuses (HP:0002687)1.88693418
103Abnormality of the fingertips (HP:0001211)1.88592047
104Abnormality of iron homeostasis (HP:0011031)1.88465301
105Abnormality of transition element cation homeostasis (HP:0011030)1.87714804
106Hand muscle atrophy (HP:0009130)1.87685467
107Overlapping toe (HP:0001845)1.86730262
108Abnormality of the right ventricle (HP:0001707)1.83551810
109Macroorchidism (HP:0000053)1.83537181
110Gangrene (HP:0100758)1.82822355
111Hyperammonemia (HP:0001987)1.82217123
112Elevated erythrocyte sedimentation rate (HP:0003565)1.81438803
113Spondylolisthesis (HP:0003302)1.80582592
114Impaired platelet aggregation (HP:0003540)1.80407232
115Abnormal platelet function (HP:0011869)1.80407232
116Lip pit (HP:0100267)1.80053751
117Low anterior hairline (HP:0000294)1.79976263
118Abnormality of T cell number (HP:0011839)1.79357607
119Gastrointestinal stroma tumor (HP:0100723)1.79068771
120Aortic aneurysm (HP:0004942)1.78178622
121Prostate neoplasm (HP:0100787)1.77599501
122Abnormal delayed hypersensitivity skin test (HP:0002963)1.77354266
123Osteomyelitis (HP:0002754)1.77086474
124Aplasia cutis congenita (HP:0001057)1.76518626
125Increased CSF protein (HP:0002922)1.76304458
126Keratitis (HP:0000491)1.76279114
127Periodontitis (HP:0000704)1.75384814
128Abnormality of the lumbar spine (HP:0100712)1.74933709
129Recurrent skin infections (HP:0001581)1.74665886
130Hypoglycemic coma (HP:0001325)1.74037086
131Colitis (HP:0002583)1.73570213
132Upper limb amyotrophy (HP:0009129)1.73152227
133Distal upper limb amyotrophy (HP:0007149)1.73152227
134Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.73141910
135Increased cerebral lipofuscin (HP:0011813)1.72720394
136Increased IgE level (HP:0003212)1.72279645
137Bilateral sensorineural hearing impairment (HP:0008619)1.72008275
138Coarse hair (HP:0002208)1.71336144
139Abnormality of the intrinsic pathway (HP:0010989)1.71064257
140Increased density of long bones (HP:0006392)1.70479414
141Abnormal cartilage morphology (HP:0002763)1.70285016
142Aneurysm (HP:0002617)1.70101552
143Disinhibition (HP:0000734)1.70038977
144Neoplasm of the tracheobronchial system (HP:0100552)1.69673892
145Increased serum ferritin (HP:0003281)1.69598152
146Gastrointestinal infarctions (HP:0005244)1.69423446
147Pulmonary infiltrates (HP:0002113)1.69384625
148Cutis marmorata (HP:0000965)1.68999591
149Recurrent cutaneous fungal infections (HP:0011370)1.68655295
150Chronic mucocutaneous candidiasis (HP:0002728)1.68655295
151Abnormal foot bone ossification (HP:0010675)1.68560731
152Abnormality of pyrimidine metabolism (HP:0004353)1.68000980
153Hemoptysis (HP:0002105)1.67770731
154Interstitial pulmonary disease (HP:0006530)1.67689273
155Disproportionate tall stature (HP:0001519)1.67620106
156Mitral stenosis (HP:0001718)1.67146947
157Somatic mutation (HP:0001428)1.66156171
158Meningitis (HP:0001287)1.65401610
159Deviation of the thumb (HP:0009603)1.65396828
160Papillary thyroid carcinoma (HP:0002895)1.65310994
161Recurrent bacterial skin infections (HP:0005406)1.64850537
162Submucous cleft hard palate (HP:0000176)1.64238855
163Personality changes (HP:0000751)1.63633621
164Lymphopenia (HP:0001888)1.63320098
165Abnormality of T cell physiology (HP:0011840)1.63198514
166Chromosomal breakage induced by crosslinking agents (HP:0003221)1.63096221
167Abnormality of aspartate family amino acid metabolism (HP:0010899)1.62535268
168Squamous cell carcinoma (HP:0002860)1.62511782
169Gingivitis (HP:0000230)1.62439607
170Conjugated hyperbilirubinemia (HP:0002908)1.61894556
171Urticaria (HP:0001025)1.61862278
172Menorrhagia (HP:0000132)1.61659119
173Conjunctival telangiectasia (HP:0000524)1.61007540
174Thrombophlebitis (HP:0004418)1.60890991
175Progressive sensorineural hearing impairment (HP:0000408)1.60608953
176Thin bony cortex (HP:0002753)1.59353464
177Papilloma (HP:0012740)1.58827459
178Verrucae (HP:0200043)1.58827459
179Metaphyseal cupping (HP:0003021)1.58535155
180Nephritis (HP:0000123)1.57339065
181Abnormality of nucleobase metabolism (HP:0010932)1.57337130
182Hyperacusis (HP:0010780)1.56697527
183Abnormality of serine family amino acid metabolism (HP:0010894)1.56300806
184Abnormality of glycine metabolism (HP:0010895)1.56300806

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK23.78111461
2TRIB33.37324519
3PKN23.28269311
4PRPF4B3.17672136
5EEF2K3.07212280
6MAP3K102.97432897
7CDK122.88215362
8ERN12.83328748
9IRAK32.77168919
10SIK32.36638606
11MAP4K12.24575869
12STK102.17908379
13AKT32.14809745
14FGFR42.09401395
15BMPR22.07233033
16SIK12.05113578
17EPHB12.01676425
18PTK61.98066544
19RIPK11.78009871
20TYK21.77744867
21IRAK41.75551065
22EIF2AK31.70354147
23LATS11.68650123
24SCYL21.65389049
25NEK61.61798400
26CAMK1D1.59513541
27GRK61.59034882
28YES11.58335386
29CDK61.56578677
30LRRK21.55074404
31RIPK41.52122005
32TAOK31.49022899
33IRAK11.43143671
34BMX1.38060282
35TAOK21.35460144
36JAK11.34731809
37IRAK21.34717592
38STK31.30323882
39NEK21.28753603
40FGFR31.26571672
41CSK1.26455489
42TBK11.26014277
43JAK31.23325304
44FLT31.21102579
45CDK41.17991539
46PIM11.15312040
47MTOR1.13485177
48MST1R1.11852166
49ALK1.11301852
50BRSK21.11236166
51MAP3K81.06957771
52TTN1.04671020
53RPS6KA41.04458493
54JAK21.03924470
55TGFBR21.03577431
56FRK1.02691437
57PDGFRA1.01005289
58MAP3K131.00899300
59STK41.00858951
60CAMK1G0.99009744
61RPS6KB20.98143229
62SMG10.97901991
63MAP3K140.95749218
64ACVR1B0.93498709
65EPHA20.92995243
66TXK0.92003115
67MET0.91572540
68ZAP700.90680807
69MAP3K30.89196428
70PDGFRB0.89066788
71EIF2AK10.88950753
72ITK0.87439506
73PAK20.86337636
74RAF10.83510727
75PIM20.82214985
76DYRK1B0.80171079
77CDC70.79868956
78MAP2K30.79676953
79BRD40.78641904
80CSF1R0.78550924
81MKNK10.78461683
82EPHA30.78247974
83TRPM70.78088566
84MKNK20.77013864
85BLK0.74002780
86CHUK0.73474780
87HCK0.71599871
88MAPK110.71346681
89HIPK20.70648498
90EIF2AK20.70357068
91BTK0.69423534
92NLK0.68115759
93CDK90.67639794
94MELK0.67468751
95PTK20.67173150
96TSSK60.66048458
97MAPK120.65283620
98PDPK10.65123671
99MARK30.64743017
100IKBKB0.63953155
101GSK3A0.63927411
102PAK40.62715644
103IKBKE0.62428628
104MAPK70.59952576
105RET0.59885809
106MATK0.59450995
107NEK90.59132164
108WEE10.58866599
109MAP3K20.55952679
110ICK0.55761521
111TESK20.55515921
112ERBB30.55095999
113DDR20.54834530
114GRK70.54137022
115MAP3K10.53656514
116BCKDK0.51950556
117EGFR0.51859987
118LATS20.51616593
119ERBB40.49460723
120MAP3K70.49186382
121FGFR20.48718062
122LCK0.48466909
123PRKAA20.48049756
124CLK10.47475948
125FGFR10.47259215
126CDK30.45361978
127MAP2K20.43727951
128KSR20.43689974
129KSR10.43043009
130LYN0.42408631
131RPS6KB10.42014925
132ABL10.41825359
133FGR0.41683045
134TTK0.40549183
135CHEK10.39882447
136MAPK30.37853068
137MST40.37715341
138RPS6KA10.36586797
139TAOK10.36336364
140PDK10.33818892
141SGK30.33368003
142SYK0.33354632
143AURKB0.32933340
144CSNK1D0.32667956
145INSR0.32562614

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.20171834
2Primary bile acid biosynthesis_Homo sapiens_hsa001202.46062526
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.39907283
4Arginine biosynthesis_Homo sapiens_hsa002202.03928622
5Caffeine metabolism_Homo sapiens_hsa002322.03568803
6Staphylococcus aureus infection_Homo sapiens_hsa051502.01819763
7Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.93357759
8Complement and coagulation cascades_Homo sapiens_hsa046101.85411422
9Selenocompound metabolism_Homo sapiens_hsa004501.69291257
10Fat digestion and absorption_Homo sapiens_hsa049751.68390048
11Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.67646197
12PPAR signaling pathway_Homo sapiens_hsa033201.57880487
13Fatty acid degradation_Homo sapiens_hsa000711.54856473
14Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.53395298
15Lysine degradation_Homo sapiens_hsa003101.53205455
16Tryptophan metabolism_Homo sapiens_hsa003801.51462538
17One carbon pool by folate_Homo sapiens_hsa006701.45392348
18Tuberculosis_Homo sapiens_hsa051521.41882473
19Other glycan degradation_Homo sapiens_hsa005111.38917770
20FoxO signaling pathway_Homo sapiens_hsa040681.37053209
21Pentose and glucuronate interconversions_Homo sapiens_hsa000401.36331103
22Prolactin signaling pathway_Homo sapiens_hsa049171.34613197
23Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.32272439
24Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.28731028
25Prostate cancer_Homo sapiens_hsa052151.28133368
26Allograft rejection_Homo sapiens_hsa053301.20835716
27ABC transporters_Homo sapiens_hsa020101.20061737
28Renal cell carcinoma_Homo sapiens_hsa052111.16825385
29Chronic myeloid leukemia_Homo sapiens_hsa052201.15071419
30Leishmaniasis_Homo sapiens_hsa051401.12545956
31Drug metabolism - other enzymes_Homo sapiens_hsa009831.12196304
32Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.11777794
33Endometrial cancer_Homo sapiens_hsa052131.11304022
34Bile secretion_Homo sapiens_hsa049761.11268952
35Pertussis_Homo sapiens_hsa051331.10355472
36African trypanosomiasis_Homo sapiens_hsa051431.10207563
37NF-kappa B signaling pathway_Homo sapiens_hsa040641.09556223
38Fatty acid metabolism_Homo sapiens_hsa012121.09125420
39Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.08870911
40Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.08364759
41Graft-versus-host disease_Homo sapiens_hsa053321.07025466
42B cell receptor signaling pathway_Homo sapiens_hsa046621.05351609
43Insulin resistance_Homo sapiens_hsa049311.04937629
44Osteoclast differentiation_Homo sapiens_hsa043801.02274142
45Small cell lung cancer_Homo sapiens_hsa052221.01132813
46Adipocytokine signaling pathway_Homo sapiens_hsa049200.99103210
47Inositol phosphate metabolism_Homo sapiens_hsa005620.97367131
48Histidine metabolism_Homo sapiens_hsa003400.97114987
49Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.96922054
50Toxoplasmosis_Homo sapiens_hsa051450.94398706
51Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.94024462
52Starch and sucrose metabolism_Homo sapiens_hsa005000.93865169
53Fatty acid biosynthesis_Homo sapiens_hsa000610.93511155
54Neurotrophin signaling pathway_Homo sapiens_hsa047220.92704749
55Epstein-Barr virus infection_Homo sapiens_hsa051690.91421387
56Phosphatidylinositol signaling system_Homo sapiens_hsa040700.91313072
57Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.91153091
58Thyroid cancer_Homo sapiens_hsa052160.90442815
59Autoimmune thyroid disease_Homo sapiens_hsa053200.90304010
60Biosynthesis of amino acids_Homo sapiens_hsa012300.89369102
61Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.89368752
62ErbB signaling pathway_Homo sapiens_hsa040120.89315269
63Longevity regulating pathway - mammal_Homo sapiens_hsa042110.88991135
64Colorectal cancer_Homo sapiens_hsa052100.88514314
65Asthma_Homo sapiens_hsa053100.88378646
66Chemokine signaling pathway_Homo sapiens_hsa040620.87704136
67Legionellosis_Homo sapiens_hsa051340.87417456
68HTLV-I infection_Homo sapiens_hsa051660.86550594
69Acute myeloid leukemia_Homo sapiens_hsa052210.85510983
70VEGF signaling pathway_Homo sapiens_hsa043700.85095505
71Antigen processing and presentation_Homo sapiens_hsa046120.83947710
72Rheumatoid arthritis_Homo sapiens_hsa053230.83424826
73Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.83012980
74HIF-1 signaling pathway_Homo sapiens_hsa040660.82887363
75Pentose phosphate pathway_Homo sapiens_hsa000300.82876360
76Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.82786528
77Steroid biosynthesis_Homo sapiens_hsa001000.82511729
78Systemic lupus erythematosus_Homo sapiens_hsa053220.81709228
79Apoptosis_Homo sapiens_hsa042100.81406495
80Dorso-ventral axis formation_Homo sapiens_hsa043200.81220656
81Vitamin digestion and absorption_Homo sapiens_hsa049770.81189384
82Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.81168605
83Viral carcinogenesis_Homo sapiens_hsa052030.80554233
84Cyanoamino acid metabolism_Homo sapiens_hsa004600.80476147
85Measles_Homo sapiens_hsa051620.79447509
86beta-Alanine metabolism_Homo sapiens_hsa004100.77787647
87Glycerolipid metabolism_Homo sapiens_hsa005610.77359524
88Toll-like receptor signaling pathway_Homo sapiens_hsa046200.77332172
89TNF signaling pathway_Homo sapiens_hsa046680.75779954
90Type I diabetes mellitus_Homo sapiens_hsa049400.75661033
91Type II diabetes mellitus_Homo sapiens_hsa049300.74652415
92MicroRNAs in cancer_Homo sapiens_hsa052060.74183087
932-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.73435951
94mRNA surveillance pathway_Homo sapiens_hsa030150.73263110
95Peroxisome_Homo sapiens_hsa041460.72308828
96Shigellosis_Homo sapiens_hsa051310.71975876
97mTOR signaling pathway_Homo sapiens_hsa041500.71700736
98Pancreatic cancer_Homo sapiens_hsa052120.71505571
99p53 signaling pathway_Homo sapiens_hsa041150.71445395
100Leukocyte transendothelial migration_Homo sapiens_hsa046700.71291731
101Herpes simplex infection_Homo sapiens_hsa051680.70085722
102Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.69874039
103Hepatitis B_Homo sapiens_hsa051610.69509229
104Chemical carcinogenesis_Homo sapiens_hsa052040.68510368
105Carbon metabolism_Homo sapiens_hsa012000.68409927
106Hepatitis C_Homo sapiens_hsa051600.68309364
107Salmonella infection_Homo sapiens_hsa051320.68248206
108Influenza A_Homo sapiens_hsa051640.67814108
109Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.67323393
110Primary immunodeficiency_Homo sapiens_hsa053400.67158128
111Propanoate metabolism_Homo sapiens_hsa006400.66722067
112Lysosome_Homo sapiens_hsa041420.66619042
113Folate biosynthesis_Homo sapiens_hsa007900.66502964
114Sphingolipid metabolism_Homo sapiens_hsa006000.65847783
115NOD-like receptor signaling pathway_Homo sapiens_hsa046210.65623724
116Sulfur metabolism_Homo sapiens_hsa009200.64309222
117Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.63841758
118Renin-angiotensin system_Homo sapiens_hsa046140.63506371
119Sphingolipid signaling pathway_Homo sapiens_hsa040710.62712987
120Cell cycle_Homo sapiens_hsa041100.61994063
121Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.61904326
122Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.61686682
123Glioma_Homo sapiens_hsa052140.61062776
124Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.60035110
125Malaria_Homo sapiens_hsa051440.59255718
126TGF-beta signaling pathway_Homo sapiens_hsa043500.58722252
127AMPK signaling pathway_Homo sapiens_hsa041520.58528337
128Proteoglycans in cancer_Homo sapiens_hsa052050.57491495
129Jak-STAT signaling pathway_Homo sapiens_hsa046300.57198218
130Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.56891879
131Bladder cancer_Homo sapiens_hsa052190.56662501
132Central carbon metabolism in cancer_Homo sapiens_hsa052300.56537892
133Intestinal immune network for IgA production_Homo sapiens_hsa046720.56417278
134Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.56000866
135Butanoate metabolism_Homo sapiens_hsa006500.55852460
136RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.54593917
137Thyroid hormone signaling pathway_Homo sapiens_hsa049190.54476008
138Amoebiasis_Homo sapiens_hsa051460.54400318
139Cysteine and methionine metabolism_Homo sapiens_hsa002700.54317603
140Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.54268044
141Viral myocarditis_Homo sapiens_hsa054160.53967860
142Insulin signaling pathway_Homo sapiens_hsa049100.52411863
143Adherens junction_Homo sapiens_hsa045200.52368440
144Retinol metabolism_Homo sapiens_hsa008300.51614048
145T cell receptor signaling pathway_Homo sapiens_hsa046600.51398669
146Non-small cell lung cancer_Homo sapiens_hsa052230.51330048
147AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.50864086
148Hematopoietic cell lineage_Homo sapiens_hsa046400.50213736
149RNA transport_Homo sapiens_hsa030130.50097977
150Transcriptional misregulation in cancer_Homo sapiens_hsa052020.50087170
151Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.47857743
152Choline metabolism in cancer_Homo sapiens_hsa052310.46106937

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