PPP1R16B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is membrane-associated and contains five ankyrin repeats, a protein phosphatase-1-interacting domain, and a carboxy-terminal CAAX box domain. Synthesis of the encoded protein is inhibited by transforming growth factor beta-1. The protein may bind to the membrane through its CAAX box domain and may act as a signaling molecule through interaction with protein phosphatase-1. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing to generate mature protein. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1axon ensheathment in central nervous system (GO:0032291)9.16581824
2central nervous system myelination (GO:0022010)9.16581824
3negative regulation of neurotransmitter secretion (GO:0046929)6.94603852
4myelination (GO:0042552)6.33303304
5axon ensheathment (GO:0008366)6.24103858
6ensheathment of neurons (GO:0007272)6.24103858
7long-chain fatty acid biosynthetic process (GO:0042759)5.89120441
8negative regulation of neurotransmitter transport (GO:0051589)5.79149024
9regulation of B cell receptor signaling pathway (GO:0050855)5.42045952
10positive regulation of gamma-delta T cell activation (GO:0046645)5.35814829
11fatty acid elongation (GO:0030497)5.00865614
12B cell receptor signaling pathway (GO:0050853)4.96971587
13myelination in peripheral nervous system (GO:0022011)4.96846361
14peripheral nervous system axon ensheathment (GO:0032292)4.96846361
15negative thymic T cell selection (GO:0045060)4.95942895
16negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.84751080
17negative regulation of cell killing (GO:0031342)4.84751080
18astrocyte development (GO:0014002)4.83345393
19negative T cell selection (GO:0043383)4.82969999
20presynaptic membrane assembly (GO:0097105)4.81552428
21presynaptic membrane organization (GO:0097090)4.67199346
22antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.59935532
23positive thymic T cell selection (GO:0045059)4.58025443
24thymic T cell selection (GO:0045061)4.56554056
25negative regulation of peptidyl-threonine phosphorylation (GO:0010801)4.54925553
26positive regulation of Rap GTPase activity (GO:0032854)4.52852303
27neuronal action potential propagation (GO:0019227)4.52028113
28oligodendrocyte differentiation (GO:0048709)4.48589536
29positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.43503703
30positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.42642524
31antigen processing and presentation of endogenous antigen (GO:0019883)4.41023137
32antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.40219288
33response to interleukin-15 (GO:0070672)4.30675148
34cellular response to interleukin-15 (GO:0071350)4.27758000
35T cell migration (GO:0072678)4.26268245
36neuron cell-cell adhesion (GO:0007158)4.18299157
37positive T cell selection (GO:0043368)4.15769683
38L-amino acid import (GO:0043092)4.06621837
39T cell selection (GO:0045058)4.03566285
40regulation of ARF protein signal transduction (GO:0032012)4.02910093
41antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.01536410
42regulation of gamma-delta T cell activation (GO:0046643)4.00210952
43regulation of gamma-delta T cell differentiation (GO:0045586)3.93800868
44regulation of Rap GTPase activity (GO:0032317)3.93439634
45synaptic vesicle docking involved in exocytosis (GO:0016081)3.92614822
46synaptic vesicle maturation (GO:0016188)3.90546938
47myelin maintenance (GO:0043217)3.88412859
48glycerophospholipid catabolic process (GO:0046475)3.86912495
49CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.80797010
50transmission of nerve impulse (GO:0019226)3.76144010
51cyclic nucleotide catabolic process (GO:0009214)3.69866988
52synaptic vesicle exocytosis (GO:0016079)3.69187708
53B cell homeostasis (GO:0001782)3.64752883
54tolerance induction (GO:0002507)3.62045712
55regulation of synaptic vesicle exocytosis (GO:2000300)3.60911789
56eye photoreceptor cell differentiation (GO:0001754)3.60548339
57photoreceptor cell differentiation (GO:0046530)3.60548339
58positive regulation of B cell differentiation (GO:0045579)3.60308311
59regulation of B cell differentiation (GO:0045577)3.53123389
60cellular response to epinephrine stimulus (GO:0071872)3.51743566
61germinal center formation (GO:0002467)3.49615292
62glutamate secretion (GO:0014047)3.44778877
63negative regulation of synaptic transmission, GABAergic (GO:0032229)3.44256372
64adult walking behavior (GO:0007628)3.44094240
65adhesion of symbiont to host cell (GO:0044650)3.40193279
66virion attachment to host cell (GO:0019062)3.40193279
67asymmetric protein localization (GO:0008105)3.31529040
68peripheral nervous system development (GO:0007422)3.30211706
69cerebellar granule cell differentiation (GO:0021707)3.28050572
70positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.27573701
71amino acid import (GO:0043090)3.27356387
72regulation of collateral sprouting (GO:0048670)3.26928247
73substantia nigra development (GO:0021762)3.25469001
74signal complex assembly (GO:0007172)3.24984419
75apical protein localization (GO:0045176)3.22325401
76negative regulation of execution phase of apoptosis (GO:1900118)3.22248593
77antigen receptor-mediated signaling pathway (GO:0050851)3.21451976
78cellular response to catecholamine stimulus (GO:0071870)3.21337893
79cellular response to monoamine stimulus (GO:0071868)3.21337893
80negative regulation of erythrocyte differentiation (GO:0045647)3.19793159
81negative regulation of protein localization to cell surface (GO:2000009)3.19138256
82negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.19063159
83establishment of mitochondrion localization (GO:0051654)3.18895298
84dendritic spine organization (GO:0097061)3.18617614
85interferon-gamma-mediated signaling pathway (GO:0060333)3.16543888
86NIK/NF-kappaB signaling (GO:0038061)3.15222120
87regulation of long-term neuronal synaptic plasticity (GO:0048169)3.12743321
88negative regulation of T cell mediated immunity (GO:0002710)3.12562957
89phosphatidylinositol 3-kinase signaling (GO:0014065)3.12510496
90dendritic spine morphogenesis (GO:0060997)3.12491538
91response to redox state (GO:0051775)3.11665150
92negative regulation of Rho protein signal transduction (GO:0035024)3.11423739
93regulation of alpha-beta T cell proliferation (GO:0046640)3.10410368
94regulation of interleukin-2 biosynthetic process (GO:0045076)3.09229357
95negative regulation of synaptic transmission (GO:0050805)3.08532566
96response to muramyl dipeptide (GO:0032495)3.08461341
97regulation of isotype switching to IgG isotypes (GO:0048302)3.08303555
98regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.07653922
99ionotropic glutamate receptor signaling pathway (GO:0035235)3.06533800
100regulation of synaptic transmission, GABAergic (GO:0032228)3.04528684
101cellular response to type I interferon (GO:0071357)3.04460413
102type I interferon signaling pathway (GO:0060337)3.04460413
103response to type I interferon (GO:0034340)3.02568558
104positive regulation of action potential (GO:0045760)3.02335728
105cerebral cortex radially oriented cell migration (GO:0021799)3.01473517
106negative regulation of myoblast differentiation (GO:0045662)2.99740162
107mucosal-associated lymphoid tissue development (GO:0048537)2.99116855
108Peyers patch development (GO:0048541)2.99116855
109T cell costimulation (GO:0031295)2.98465900
110regulation of synaptic vesicle transport (GO:1902803)2.97424426
111response to epinephrine (GO:0071871)2.97354247
112lymphocyte costimulation (GO:0031294)2.95142814
113activated T cell proliferation (GO:0050798)2.94584534
114regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.94263593
115gamma-aminobutyric acid signaling pathway (GO:0007214)2.94240278
116leukocyte aggregation (GO:0070486)2.93537539
117negative regulation of lymphocyte mediated immunity (GO:0002707)2.92678717
118response to monoamine (GO:0071867)2.87358918
119response to catecholamine (GO:0071869)2.87358918
120neuronal ion channel clustering (GO:0045161)2.86644714
121interferon-gamma production (GO:0032609)2.85439638
122synaptic transmission, glutamatergic (GO:0035249)2.85291277
123myeloid dendritic cell differentiation (GO:0043011)2.84275071
124centrosome duplication (GO:0051298)2.83645624
125membrane assembly (GO:0071709)2.82966479
126lymphocyte homeostasis (GO:0002260)2.82112876
127negative regulation of leukocyte mediated immunity (GO:0002704)2.82082015
128regulation of dendritic spine development (GO:0060998)2.81868643
129negative regulation of axonogenesis (GO:0050771)2.81320315
130positive regulation of interleukin-2 production (GO:0032743)2.80606146
131glial cell development (GO:0021782)2.80098938
132T cell receptor signaling pathway (GO:0050852)2.80069998
133T cell homeostasis (GO:0043029)2.79796706
134neuron-neuron synaptic transmission (GO:0007270)2.79102272
135natural killer cell differentiation (GO:0001779)2.78084081
136mast cell activation (GO:0045576)2.77594071
137import into cell (GO:0098657)2.77119167
138sodium ion export (GO:0071436)2.76282899
139peptidyl-tyrosine autophosphorylation (GO:0038083)2.76268914
140positive regulation of dendritic spine development (GO:0060999)2.76198495
141nerve growth factor signaling pathway (GO:0038180)2.76189692
142protein localization to synapse (GO:0035418)2.74910053
143locomotory exploration behavior (GO:0035641)2.74533618
144positive regulation by symbiont of host defense response (GO:0052509)2.73492655
145modulation by symbiont of host defense response (GO:0052031)2.73492655
146modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.73492655
147modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.73492655
148positive regulation by organism of defense response of other organism involved in symbiotic interact2.73492655
149modulation by symbiont of host immune response (GO:0052553)2.73492655
150regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.71742014
151myeloid dendritic cell activation (GO:0001773)2.71736588
152regulation of neuronal synaptic plasticity (GO:0048168)2.71731956
153cerebellar Purkinje cell differentiation (GO:0021702)2.69424634
154limb bud formation (GO:0060174)2.69155139
155gamma-aminobutyric acid transport (GO:0015812)2.68598631
156cellular potassium ion homeostasis (GO:0030007)2.68349657
157glutamate receptor signaling pathway (GO:0007215)2.68195467
158vocalization behavior (GO:0071625)2.67887348
159positive regulation of alpha-beta T cell proliferation (GO:0046641)2.67350378
160positive regulation of oligodendrocyte differentiation (GO:0048714)2.67194363
161regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.66514987
162B cell proliferation (GO:0042100)2.65964352
163lymphocyte migration (GO:0072676)2.65460164
164regulation of excitatory postsynaptic membrane potential (GO:0060079)2.64150254
165detection of bacterium (GO:0016045)2.62459624
166neurotransmitter secretion (GO:0007269)2.61132753
167regulation of interleukin-4 production (GO:0032673)2.60843631
168dendrite development (GO:0016358)2.60247675
169neurotransmitter uptake (GO:0001504)2.60157443
170myelin assembly (GO:0032288)2.59973232
171positive regulation of membrane potential (GO:0045838)2.59893350
172regulation of dendritic cell antigen processing and presentation (GO:0002604)2.59663041
173positive regulation of granulocyte differentiation (GO:0030854)2.59024714
174positive regulation of interleukin-4 production (GO:0032753)2.58856620
175cholesterol biosynthetic process (GO:0006695)2.58599180
176regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.57735349
177negative regulation of axon extension (GO:0030517)2.57648048
178regulation of short-term neuronal synaptic plasticity (GO:0048172)2.57426255
179regulation of glutamate secretion (GO:0014048)2.57309682
180creatine metabolic process (GO:0006600)2.57177214
181GPI anchor biosynthetic process (GO:0006506)2.56853695
182neuron recognition (GO:0008038)2.55348403
183regulation of natural killer cell mediated immunity (GO:0002715)2.54464806
184regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.54464806
185cAMP catabolic process (GO:0006198)2.53860566
186postsynaptic membrane organization (GO:0001941)2.53469644
187regulation of B cell proliferation (GO:0030888)2.53149032
188regulation of establishment of cell polarity (GO:2000114)2.52854924
189regulation of dendritic spine morphogenesis (GO:0061001)2.52841637
190membrane tubulation (GO:0097320)2.52496742
191macrophage activation involved in immune response (GO:0002281)2.52302934
192positive regulation of B cell activation (GO:0050871)2.51848493
193mast cell activation involved in immune response (GO:0002279)2.51167427
194startle response (GO:0001964)2.48192090

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.82797514
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.27334590
3MYC_22102868_ChIP-Seq_BL_Human3.97499689
4EZH2_22144423_ChIP-Seq_EOC_Human3.93942534
5GBX2_23144817_ChIP-Seq_PC3_Human3.81910116
6BP1_19119308_ChIP-ChIP_Hs578T_Human3.28333427
7* RUNX_20019798_ChIP-Seq_JUKART_Human3.05407242
8KDM2B_26808549_Chip-Seq_SUP-B15_Human2.81050101
9* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.80904115
10FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.61156370
11* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.60579078
12NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.60320834
13JARID2_20064375_ChIP-Seq_MESCs_Mouse2.60049809
14IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.59901173
15* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.59246700
16MAF_26560356_Chip-Seq_TH1_Human2.57706994
17SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.54514148
18VDR_21846776_ChIP-Seq_THP-1_Human2.52313196
19STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.49062730
20VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.48056930
21THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.46960867
22* MYB_26560356_Chip-Seq_TH2_Human2.45122411
23* TCF7_22412390_ChIP-Seq_EML_Mouse2.42439715
24IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.35320382
25SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.33473314
26TAF15_26573619_Chip-Seq_HEK293_Human2.29220145
27KDM2B_26808549_Chip-Seq_DND41_Human2.28859043
28TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.27076481
29EGR1_19374776_ChIP-ChIP_THP-1_Human2.25161205
30* EZH2_27304074_Chip-Seq_ESCs_Mouse2.23465689
31KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.23234419
32SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.21687044
33EZH2_18974828_ChIP-Seq_MESCs_Mouse2.19061001
34RNF2_18974828_ChIP-Seq_MESCs_Mouse2.19061001
35EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.17368615
36SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.16262829
37* KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.12633691
38SCL_19346495_ChIP-Seq_HPC-7_Human2.10971856
39ZFP57_27257070_Chip-Seq_ESCs_Mouse2.10570882
40SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.09866846
41AR_21572438_ChIP-Seq_LNCaP_Human2.09709593
42EED_16625203_ChIP-ChIP_MESCs_Mouse2.08725262
43SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.08704440
44* SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.08520374
45* MYB_26560356_Chip-Seq_TH1_Human2.08240796
46UTX_26944678_Chip-Seq_JUKART_Human2.07434595
47IKZF1_21737484_ChIP-ChIP_HCT116_Human2.05832760
48STAT4_19710469_ChIP-ChIP_TH1__Mouse2.03098569
49* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.02217244
50DROSHA_22980978_ChIP-Seq_HELA_Human2.01081874
51CDX2_19796622_ChIP-Seq_MESCs_Mouse2.00800043
52MAF_26560356_Chip-Seq_TH2_Human1.99705071
53* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.97958608
54* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.97388658
55VDR_24763502_ChIP-Seq_THP-1_Human1.95652294
56* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.95252914
57* EZH2_27294783_Chip-Seq_ESCs_Mouse1.94925144
58* RNF2_27304074_Chip-Seq_ESCs_Mouse1.89447304
59IRF8_21731497_ChIP-ChIP_J774_Mouse1.84508496
60OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.82551272
61IRF8_27001747_Chip-Seq_BMDM_Mouse1.81647169
62CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.79090370
63CBX2_27304074_Chip-Seq_ESCs_Mouse1.78569261
64MYB_21317192_ChIP-Seq_ERMYB_Mouse1.78535127
65GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.76273678
66RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.74685432
67KDM2B_26808549_Chip-Seq_JURKAT_Human1.73001231
68LXR_22292898_ChIP-Seq_THP-1_Human1.72669424
69NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.70256369
70CTBP1_25329375_ChIP-Seq_LNCAP_Human1.69698640
71NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.64739836
72TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.63751655
73RUNX1_22412390_ChIP-Seq_EML_Mouse1.62553510
74PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.62441151
75SPI1_23127762_ChIP-Seq_K562_Human1.60029951
76* GATA3_27048872_Chip-Seq_THYMUS_Human1.57940477
77RARB_27405468_Chip-Seq_BRAIN_Mouse1.57706461
78REST_21632747_ChIP-Seq_MESCs_Mouse1.56773725
79PIAS1_25552417_ChIP-Seq_VCAP_Human1.56311042
80RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.55168412
81POU3F2_20337985_ChIP-ChIP_501MEL_Human1.53924364
82ER_23166858_ChIP-Seq_MCF-7_Human1.53797663
83SMAD3_21741376_ChIP-Seq_EPCs_Human1.52331853
84GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.51927667
85GATA1_19941827_ChIP-Seq_MEL_Mouse1.48848050
86P300_19829295_ChIP-Seq_ESCs_Human1.48728491
87SMAD_19615063_ChIP-ChIP_OVARY_Human1.46889777
88SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.46828901
89* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.45073519
90KDM2B_26808549_Chip-Seq_K562_Human1.44323718
91BRD4_27068464_Chip-Seq_AML-cells_Mouse1.43523857
92MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.41488532
93* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.41452063
94* SMAD4_21799915_ChIP-Seq_A2780_Human1.41093337
95BMI1_23680149_ChIP-Seq_NPCS_Mouse1.40425508
96DNAJC2_21179169_ChIP-ChIP_NT2_Human1.39585081
97TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.37382538
98CIITA_25753668_ChIP-Seq_RAJI_Human1.36462429
99* STAT3_23295773_ChIP-Seq_U87_Human1.36242406
100SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.34637053
101FUS_26573619_Chip-Seq_HEK293_Human1.34548419
102STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.32504980
103GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.31861653
104SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.30319773
105PCGF2_27294783_Chip-Seq_ESCs_Mouse1.28986925
106RNF2_27304074_Chip-Seq_NSC_Mouse1.28141609
107VDR_22108803_ChIP-Seq_LS180_Human1.27496253
108AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.26376407
109* TCF4_23295773_ChIP-Seq_U87_Human1.25280214
110PU.1_20513432_ChIP-Seq_Bcells_Mouse1.24761227
111SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.24386827
112MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.24270378
113* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.24223232
114* REST_18959480_ChIP-ChIP_MESCs_Mouse1.24024015
115P53_22127205_ChIP-Seq_FIBROBLAST_Human1.22784672
116GATA1_19941826_ChIP-Seq_K562_Human1.21426767
117SUZ12_27294783_Chip-Seq_NPCs_Mouse1.21238752
118NANOG_18555785_Chip-Seq_ESCs_Mouse1.21191920
119SPI1_23547873_ChIP-Seq_NB4_Human1.18980551
120* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.18790911
121ZFP281_18757296_ChIP-ChIP_E14_Mouse1.18345481
122ZFP281_27345836_Chip-Seq_ESCs_Mouse1.17590835
123FLI1_27457419_Chip-Seq_LIVER_Mouse1.16429167
124TOP2B_26459242_ChIP-Seq_MCF-7_Human1.15007600
125* P300_18555785_Chip-Seq_ESCs_Mouse1.14726610
126FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.14635108
127NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.13966772
128AHR_22903824_ChIP-Seq_MCF-7_Human1.13832276
129EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.13795996
130* CMYC_18555785_Chip-Seq_ESCs_Mouse1.13578221
131ELK3_25401928_ChIP-Seq_HUVEC_Human1.13350816
132PCGF2_27294783_Chip-Seq_NPCs_Mouse1.13037809
133CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.12743018
134PRDM14_20953172_ChIP-Seq_ESCs_Human1.11990302
135GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.10834519
136E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.10676487
137RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.10263966
138RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.09917516
139TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.09886682
140BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.09415989
141GATA1_22025678_ChIP-Seq_K562_Human1.08789233
142* E2F1_18555785_Chip-Seq_ESCs_Mouse1.08468308
143P53_22387025_ChIP-Seq_ESCs_Mouse1.08403512
144* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.07665292
145LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.07268038
146TAL1_26923725_Chip-Seq_HPCs_Mouse1.07244156
147PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.07023906
148ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.06929447
149LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06847532
150EZH2_27294783_Chip-Seq_NPCs_Mouse1.05590612
151* GATA2_21666600_ChIP-Seq_HMVEC_Human1.04394146
152MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.03990097
153TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.03530162
154ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.03229321
155* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.03185123
156NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.00526271
157STAT3_18555785_Chip-Seq_ESCs_Mouse1.00430014
158ARNT_22903824_ChIP-Seq_MCF-7_Human1.00228150
159FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.00113372
160TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99977512
161POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.99977512
162CTCF_27219007_Chip-Seq_ERYTHROID_Human0.99966653
163VDR_24787735_ChIP-Seq_THP-1_Human0.99903259
164IRF1_19129219_ChIP-ChIP_H3396_Human0.99372361
165SOX2_21211035_ChIP-Seq_LN229_Gbm0.99148954
166RUNX1_27457419_Chip-Seq_LIVER_Mouse0.98871666
167SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.98595304
168NFE2_27457419_Chip-Seq_LIVER_Mouse0.98230928
169* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.98143620
170GATA2_22383799_ChIP-Seq_G1ME_Mouse0.98137494
171LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.98081191
172NR3C1_21868756_ChIP-Seq_MCF10A_Human0.97744776
173SMC4_20622854_ChIP-Seq_HELA_Human0.97470412
174* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.97466800
175ZNF217_24962896_ChIP-Seq_MCF-7_Human0.97016249
176RING1B_27294783_Chip-Seq_NPCs_Mouse0.96981650
177WT1_19549856_ChIP-ChIP_CCG9911_Human0.96463105
178* RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.95879035
179RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.95264435
180PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.92922542
181DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.91735189
182GATA1_22383799_ChIP-Seq_G1ME_Mouse0.91415917
183PU_27001747_Chip-Seq_BMDM_Mouse0.91195425
184RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88705687
185* GATA3_26560356_Chip-Seq_TH2_Human0.88113318
186GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.87502387
187VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.83835670
188OCT4_19829295_ChIP-Seq_ESCs_Human0.83415404
189PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.81943083
190P68_20966046_ChIP-Seq_HELA_Human0.81705438

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.68383874
2MP0000920_abnormal_myelination4.52841217
3MP0003763_abnormal_thymus_physiology3.56874172
4MP0004859_abnormal_synaptic_plasticity3.51971070
5MP0003303_peritoneal_inflammation3.35250121
6MP0005671_abnormal_response_to3.34212172
7MP0003690_abnormal_glial_cell3.32226213
8MP0001835_abnormal_antigen_presentation3.18957703
9MP0000685_abnormal_immune_system3.08079951
10MP0004270_analgesia3.05495419
11MP0003950_abnormal_plasma_membrane3.01268653
12MP0001800_abnormal_humoral_immune3.00305039
13MP0005646_abnormal_pituitary_gland2.95037707
14MP0001790_abnormal_immune_system2.91346700
15MP0005387_immune_system_phenotype2.91346700
16MP0003136_yellow_coat_color2.86514627
17MP0002272_abnormal_nervous_system2.82733177
18MP0005000_abnormal_immune_tolerance2.80257732
19MP0002064_seizures2.79360094
20MP0001486_abnormal_startle_reflex2.70548985
21MP0005645_abnormal_hypothalamus_physiol2.69697119
22MP0003635_abnormal_synaptic_transmissio2.68552917
23MP0009745_abnormal_behavioral_response2.62808141
24MP0003436_decreased_susceptibility_to2.60081056
25MP0001905_abnormal_dopamine_level2.58758536
26MP0005409_darkened_coat_color2.49871809
27MP0004742_abnormal_vestibular_system2.46000268
28MP0009046_muscle_twitch2.43320428
29MP0005171_absent_coat_pigmentation2.35457563
30MP0002723_abnormal_immune_serum2.30589605
31MP0002420_abnormal_adaptive_immunity2.29410610
32MP0004885_abnormal_endolymph2.29092671
33MP0001819_abnormal_immune_cell2.24235560
34MP0004142_abnormal_muscle_tone2.24006116
35MP0001529_abnormal_vocalization2.21348390
36MP0002452_abnormal_antigen_presenting2.19188952
37MP0002398_abnormal_bone_marrow2.16132691
38MP0002063_abnormal_learning/memory/cond2.16025540
39MP0000778_abnormal_nervous_system2.07372458
40MP0001348_abnormal_lacrimal_gland2.03816706
41MP0001485_abnormal_pinna_reflex2.00970700
42MP0002822_catalepsy2.00866528
43MP0002572_abnormal_emotion/affect_behav2.00630182
44MP0003634_abnormal_glial_cell1.97888095
45MP0000716_abnormal_immune_system1.93069124
46MP0008569_lethality_at_weaning1.91657705
47MP0005025_abnormal_response_to1.91261573
48MP0005423_abnormal_somatic_nervous1.90375182
49MP0003300_gastrointestinal_ulcer1.89690241
50MP0002138_abnormal_hepatobiliary_system1.82060746
51MP0002734_abnormal_mechanical_nocicepti1.80599069
52MP0002229_neurodegeneration1.78820730
53MP0000703_abnormal_thymus_morphology1.73639428
54MP0009333_abnormal_splenocyte_physiolog1.68641274
55MP0003329_amyloid_beta_deposits1.68551293
56MP0002166_altered_tumor_susceptibility1.66599755
57MP0002067_abnormal_sensory_capabilities1.66324940
58MP0001873_stomach_inflammation1.64617633
59MP0005310_abnormal_salivary_gland1.62313016
60MP0004924_abnormal_behavior1.61775017
61MP0005386_behavior/neurological_phenoty1.61775017
62MP0002419_abnormal_innate_immunity1.59314790
63MP0001440_abnormal_grooming_behavior1.58219250
64MP0010155_abnormal_intestine_physiology1.57870363
65MP0001188_hyperpigmentation1.56959888
66MP0000689_abnormal_spleen_morphology1.56389468
67MP0004947_skin_inflammation1.55779673
68MP0004134_abnormal_chest_morphology1.54621878
69MP0003183_abnormal_peptide_metabolism1.54037787
70MP0003866_abnormal_defecation1.53735086
71MP0004381_abnormal_hair_follicle1.52437344
72MP0003724_increased_susceptibility_to1.51297057
73MP0002722_abnormal_immune_system1.50879349
74MP0002429_abnormal_blood_cell1.48695571
75MP0002405_respiratory_system_inflammati1.46230913
76MP0009785_altered_susceptibility_to1.44523531
77MP0003938_abnormal_ear_development1.44083282
78MP0002882_abnormal_neuron_morphology1.44053083
79MP0001968_abnormal_touch/_nociception1.43879200
80MP0002396_abnormal_hematopoietic_system1.42984306
81MP0002148_abnormal_hypersensitivity_rea1.41625591
82MP0000955_abnormal_spinal_cord1.38074503
83MP0004510_myositis1.37657170
84MP0003632_abnormal_nervous_system1.37369777
85MP0003633_abnormal_nervous_system1.37369206
86MP0000631_abnormal_neuroendocrine_gland1.36998761
87MP0003631_nervous_system_phenotype1.35524460
88MP0001177_atelectasis1.34625927
89MP0000465_gastrointestinal_hemorrhage1.31609032
90MP0002066_abnormal_motor_capabilities/c1.31424409
91MP0001502_abnormal_circadian_rhythm1.30859189
92MP0004145_abnormal_muscle_electrophysio1.28975938
93MP0001970_abnormal_pain_threshold1.28243012
94MP0005551_abnormal_eye_electrophysiolog1.24107484
95MP0005410_abnormal_fertilization1.23978126
96MP0001501_abnormal_sleep_pattern1.23030576
97MP0002006_tumorigenesis1.20660367
98MP0001963_abnormal_hearing_physiology1.18100657
99MP0001845_abnormal_inflammatory_respons1.17763054
100MP0002735_abnormal_chemical_nociception1.16998684
101MP0003045_fibrosis1.15034109
102MP0005464_abnormal_platelet_physiology1.12896158
103MP0002009_preneoplasia1.12150352
104MP0002557_abnormal_social/conspecific_i1.10679301
105MP0002752_abnormal_somatic_nervous1.10527540
106MP0002933_joint_inflammation1.07776216
107MP0003172_abnormal_lysosome_physiology1.07393508
108MP0009780_abnormal_chondrocyte_physiolo1.06492439
109MP0005167_abnormal_blood-brain_barrier1.05945134
110MP0002733_abnormal_thermal_nociception1.05232157
111MP0008057_abnormal_DNA_replication1.03914458
112MP0002736_abnormal_nociception_after1.03640434
113MP0003075_altered_response_to1.01768697
114MP0001853_heart_inflammation1.01553966
115MP0001299_abnormal_eye_distance/1.01411693
116MP0002152_abnormal_brain_morphology1.01003968
117MP0001851_eye_inflammation1.00116428
118MP0005166_decreased_susceptibility_to0.94722251
119MP0008874_decreased_physiological_sensi0.92825901
120MP0006082_CNS_inflammation0.91601559
121MP0002184_abnormal_innervation0.89984899
122MP0004043_abnormal_pH_regulation0.89468668
123MP0003091_abnormal_cell_migration0.89121298
124MP0004147_increased_porphyrin_level0.87754996
125MP0004811_abnormal_neuron_physiology0.86959954
126MP0000026_abnormal_inner_ear0.86770591
127MP0003879_abnormal_hair_cell0.85633615
128MP0006292_abnormal_olfactory_placode0.84044954
129MP0003787_abnormal_imprinting0.80848986
130MP0001533_abnormal_skeleton_physiology0.79463186
131MP0008260_abnormal_autophagy0.78957986
132MP0004808_abnormal_hematopoietic_stem0.76278721
133MP0005535_abnormal_body_temperature0.75824597
134MP0002998_abnormal_bone_remodeling0.75041731
135MP0000566_synostosis0.72812960
136MP0005451_abnormal_body_composition0.71174860
137MP0009278_abnormal_bone_marrow0.70262568
138MP0001879_abnormal_lymphatic_vessel0.69974095
139MP0000462_abnormal_digestive_system0.69389337
140MP0005623_abnormal_meninges_morphology0.69376546
141MP0005195_abnormal_posterior_eye0.67467865
142MP0001664_abnormal_digestion0.67387429
143MP0008961_abnormal_basal_metabolism0.66715370
144MP0001346_abnormal_lacrimal_gland0.66250202
145MP0005253_abnormal_eye_physiology0.65576077
146MP0002083_premature_death0.64994846
147MP0002751_abnormal_autonomic_nervous0.64614904
148MP0000604_amyloidosis0.63955105
149MP0000639_abnormal_adrenal_gland0.63711483
150MP0003011_delayed_dark_adaptation0.63496448
151MP0003937_abnormal_limbs/digits/tail_de0.63100301
152MP0005388_respiratory_system_phenotype0.62187460
153MP0002133_abnormal_respiratory_system0.62187460
154MP0000383_abnormal_hair_follicle0.59949184
155MP0001986_abnormal_taste_sensitivity0.59929457
156MP0001943_abnormal_respiration0.59652142
157MP0001984_abnormal_olfaction0.58659850
158MP0000747_muscle_weakness0.58534915
159MP0000015_abnormal_ear_pigmentation0.56622239
160MP0003861_abnormal_nervous_system0.54685111
161MP0010678_abnormal_skin_adnexa0.52015042
162MP0002069_abnormal_eating/drinking_beha0.51276160
163MP0004133_heterotaxia0.50009174

Predicted human phenotypes

RankGene SetZ-score
1Sensory axonal neuropathy (HP:0003390)5.54671207
2Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)5.46939701
3Degeneration of the lateral corticospinal tracts (HP:0002314)5.46939701
4Agammaglobulinemia (HP:0004432)4.92172405
5Gastrointestinal stroma tumor (HP:0100723)4.61206519
6Neurofibrillary tangles (HP:0002185)4.59655208
7Pheochromocytoma (HP:0002666)4.38730213
8Papilledema (HP:0001085)4.20708057
9Abnormality of the corticospinal tract (HP:0002492)4.02395424
10Abnormal auditory evoked potentials (HP:0006958)3.93095307
11Atonic seizures (HP:0010819)3.87051330
12Meningitis (HP:0001287)3.83284290
13Spastic gait (HP:0002064)3.81188377
14Focal motor seizures (HP:0011153)3.77541746
15Neuroendocrine neoplasm (HP:0100634)3.75292959
16Abnormal delayed hypersensitivity skin test (HP:0002963)3.72262148
17Panhypogammaglobulinemia (HP:0003139)3.66991372
18Peripheral hypomyelination (HP:0007182)3.65528341
19Recurrent viral infections (HP:0004429)3.64258251
20Myokymia (HP:0002411)3.63783507
21Colitis (HP:0002583)3.62183850
22Aqueductal stenosis (HP:0002410)3.61168987
23Cellulitis (HP:0100658)3.56858030
24Abnormality of binocular vision (HP:0011514)3.52869389
25Diplopia (HP:0000651)3.52869389
26Recurrent bronchitis (HP:0002837)3.49698929
27Dysmetria (HP:0001310)3.48612235
28Akinesia (HP:0002304)3.46430737
29Eczematoid dermatitis (HP:0000976)3.37669629
30IgM deficiency (HP:0002850)3.37219350
31Lymphopenia (HP:0001888)3.36657561
32Cerebral hypomyelination (HP:0006808)3.35473147
33Parakeratosis (HP:0001036)3.35354718
34Vasculitis (HP:0002633)3.35137246
35Abnormality of the parathyroid morphology (HP:0011766)3.34434193
36Recurrent sinusitis (HP:0011108)3.27149340
37Mediastinal lymphadenopathy (HP:0100721)3.24597990
38Epileptic encephalopathy (HP:0200134)3.19225179
39Abnormality of cells of the lymphoid lineage (HP:0012140)3.17738936
40Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.15690774
41Relative macrocephaly (HP:0004482)3.14947764
42Cerebral inclusion bodies (HP:0100314)3.14360291
43T lymphocytopenia (HP:0005403)3.13093918
44Scanning speech (HP:0002168)3.12837760
45Lower limb muscle weakness (HP:0007340)3.10521709
46Supranuclear gaze palsy (HP:0000605)3.10446626
47Recurrent fungal infections (HP:0002841)3.09113802
48IgA deficiency (HP:0002720)3.08633656
49Papilloma (HP:0012740)3.05735575
50Verrucae (HP:0200043)3.05735575
51Spontaneous hematomas (HP:0007420)3.05211293
52Hypoplastic pelvis (HP:0008839)3.00798551
53Abnormality of T cell number (HP:0011839)2.99904892
54Inflammation of the large intestine (HP:0002037)2.99079769
55Intention tremor (HP:0002080)2.98691234
56Hemiplegia (HP:0002301)2.97744012
57Gastrointestinal inflammation (HP:0004386)2.95858907
58Onion bulb formation (HP:0003383)2.93018076
59Chronic mucocutaneous candidiasis (HP:0002728)2.89135136
60Recurrent cutaneous fungal infections (HP:0011370)2.89135136
61Abnormality of T cells (HP:0002843)2.83127671
62Alacrima (HP:0000522)2.78129810
63Abnormality of the nasal septum (HP:0000419)2.76055096
64Absent septum pellucidum (HP:0001331)2.74457001
65Urinary bladder sphincter dysfunction (HP:0002839)2.72920580
66Generalized myoclonic seizures (HP:0002123)2.72439281
67Obstructive sleep apnea (HP:0002870)2.71959138
68IgG deficiency (HP:0004315)2.71001779
69Annular pancreas (HP:0001734)2.68925413
70Septo-optic dysplasia (HP:0100842)2.68522219
71Thickened helices (HP:0000391)2.65227252
72Duplicated collecting system (HP:0000081)2.64358859
73Encephalitis (HP:0002383)2.64013792
74Fetal akinesia sequence (HP:0001989)2.63757986
75Emphysema (HP:0002097)2.61742572
76Increased IgE level (HP:0003212)2.61057223
77Autoamputation (HP:0001218)2.60532606
78Autoimmune hemolytic anemia (HP:0001890)2.59338719
79Insidious onset (HP:0003587)2.58156445
80Termporal pattern (HP:0011008)2.58156445
81Gaze-evoked nystagmus (HP:0000640)2.57359439
82Pulmonary infiltrates (HP:0002113)2.56643074
83Abnormality of T cell physiology (HP:0011840)2.51748186
84Chronic diarrhea (HP:0002028)2.48953496
85Abnormality of the renal collecting system (HP:0004742)2.47465571
86Ankle clonus (HP:0011448)2.44316707
87Recurrent bacterial skin infections (HP:0005406)2.44274690
88Increased circulating renin level (HP:0000848)2.43892550
89Visual hallucinations (HP:0002367)2.43469006
90Restrictive lung disease (HP:0002091)2.42420389
91Broad-based gait (HP:0002136)2.40285893
92Osteomyelitis (HP:0002754)2.39618227
93Optic neuritis (HP:0100653)2.39546166
94Retrobulbar optic neuritis (HP:0100654)2.39546166
95Bowel incontinence (HP:0002607)2.37015924
96Abnormality of the septum pellucidum (HP:0007375)2.34895974
97Abnormality of the fingertips (HP:0001211)2.34644975
98Chronic otitis media (HP:0000389)2.34215744
99Premature skin wrinkling (HP:0100678)2.33137657
100Viral hepatitis (HP:0006562)2.32875188
101Neuronal loss in central nervous system (HP:0002529)2.32460452
102Hypomagnesemia (HP:0002917)2.31747220
103Diminished movement (HP:0002374)2.31472772
104Decreased lacrimation (HP:0000633)2.31465895
105Myositis (HP:0100614)2.30014653
106Abnormal large intestine physiology (HP:0012700)2.25656969
107Stomatitis (HP:0010280)2.24661232
108Hyperventilation (HP:0002883)2.23616062
109Clumsiness (HP:0002312)2.22817544
110B lymphocytopenia (HP:0010976)2.21930762
111Recurrent abscess formation (HP:0002722)2.21837054
112Chest pain (HP:0100749)2.20789461
113Paraparesis (HP:0002385)2.19406277
114Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.19256087
115Elevated erythrocyte sedimentation rate (HP:0003565)2.18886981
116Basal cell carcinoma (HP:0002671)2.18171924
117Abnormality of B cell number (HP:0010975)2.17922539
118Gastrointestinal infarctions (HP:0005244)2.16403464
119Morphological abnormality of the inner ear (HP:0011390)2.15407203
120Recurrent skin infections (HP:0001581)2.15043656
121Focal seizures (HP:0007359)2.14724672
122Febrile seizures (HP:0002373)2.13617548
123Midline defect of the nose (HP:0004122)2.13369680
124Dysdiadochokinesis (HP:0002075)2.12979110
125Metabolic alkalosis (HP:0200114)2.12693678
126Chronic obstructive pulmonary disease (HP:0006510)2.12253172
127Obstructive lung disease (HP:0006536)2.12253172
128Truncal ataxia (HP:0002078)2.12113509
129Orchitis (HP:0100796)2.10506558
130Macroorchidism (HP:0000053)2.09940766
131Tetraplegia (HP:0002445)2.08849853
132Absent/shortened dynein arms (HP:0200106)2.05480904
133Dynein arm defect of respiratory motile cilia (HP:0012255)2.05480904
134Dysmetric saccades (HP:0000641)2.04957739
135Lymphoma (HP:0002665)2.03640311
136Pulmonary embolism (HP:0002204)2.03305124
137Congenital ichthyosiform erythroderma (HP:0007431)2.01887758
138Increased IgM level (HP:0003496)2.00986809
139Leukodystrophy (HP:0002415)2.00738076
140Granulocytopenia (HP:0001913)2.00465583
141Optic nerve hypoplasia (HP:0000609)1.98942170
142Postural instability (HP:0002172)1.98450337
143Sepsis (HP:0100806)1.97959352
144Hemoptysis (HP:0002105)1.97233316
145Pustule (HP:0200039)1.97139819
146Abnormality of saccadic eye movements (HP:0000570)1.96948869
147Limb dystonia (HP:0002451)1.96440542
148Abnormality of macrophages (HP:0004311)1.94563526
149Retinal dysplasia (HP:0007973)1.94441168
150Split foot (HP:0001839)1.93397129
151Widely spaced teeth (HP:0000687)1.93222426
152Poor eye contact (HP:0000817)1.90937459
153Anomalous pulmonary venous return (HP:0010772)1.90512832
154Poor speech (HP:0002465)1.89055050
155Recurrent otitis media (HP:0000403)1.88799534
156Slow saccadic eye movements (HP:0000514)1.88728238
157Memory impairment (HP:0002354)1.87564302
158Bronchitis (HP:0012387)1.87105882
159Severe combined immunodeficiency (HP:0004430)1.85848671
160Teleangiectasia of the skin (HP:0100585)1.85492527
161Absent speech (HP:0001344)1.84079411
162Epileptiform EEG discharges (HP:0011182)1.81071785
163Conical tooth (HP:0000698)1.80318851
164CNS hypomyelination (HP:0003429)1.80130943
165Abnormality of the astrocytes (HP:0100707)1.79994331
166Astrocytoma (HP:0009592)1.79994331
167Aplasia involving bones of the upper limbs (HP:0009823)1.79619132
168Aplasia of the phalanges of the hand (HP:0009802)1.79619132
169Aplasia involving bones of the extremities (HP:0009825)1.79619132
170Overgrowth (HP:0001548)1.77003860
171White forelock (HP:0002211)1.75441731
172Action tremor (HP:0002345)1.75048954
173Seborrheic dermatitis (HP:0001051)1.73096591
174Abnormality of magnesium homeostasis (HP:0004921)1.72194517
175EEG with generalized epileptiform discharges (HP:0011198)1.71902985
176Atelectasis (HP:0100750)1.71746330
177Dysphonia (HP:0001618)1.71480335
178Abnormality of the pulmonary veins (HP:0011718)1.70541145
179Hypsarrhythmia (HP:0002521)1.69390758
180Patchy hypopigmentation of hair (HP:0011365)1.69348105
181Specific learning disability (HP:0001328)1.68917522
182Prominent occiput (HP:0000269)1.68370404
183Hypokalemic alkalosis (HP:0001949)1.67738778
184Megalencephaly (HP:0001355)1.67189921
185Blue irides (HP:0000635)1.66197364

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK44.46853421
2MAP4K14.20852271
3STK393.57226556
4LATS13.36050727
5CASK3.22627823
6OXSR12.93475049
7NUAK12.69885853
8TNIK2.21930800
9SIK22.19638055
10CAMKK12.11510833
11PRPF4B10.4425023
12EPHA41.92445196
13EPHB11.92378982
14JAK11.87213998
15DAPK21.77925634
16SYK1.74672589
17PKN11.73095987
18BCR1.71332503
19CDK191.64135064
20MAP3K101.53711650
21TYK21.52236746
22FGFR41.50773984
23BTK1.47980918
24IKBKE1.47909601
25NEK61.45028389
26CLK11.44973097
27BLK1.38338015
28FES1.33532431
29ERN11.33144881
30KSR21.32701469
31MAP3K91.32545630
32MAPK121.32529640
33WNK11.32006758
34SMG11.26804597
35UHMK11.20841487
36SIK31.19846058
37ROCK21.17390353
38FGFR21.16172974
39WNK41.16049412
40FGFR31.15663464
41JAK31.14869835
42TYRO31.11666277
43HCK1.09204135
44SGK2231.08055065
45SGK4941.08055065
46NTRK31.07206410
47CAMK2B1.06569592
48TBK11.06471261
49MAP3K131.02411982
50EEF2K1.01434421
51CSNK1A1L0.99775847
52CSNK1G30.99181177
53CDK120.98099974
54PAK60.96473836
55LCK0.95267198
56TEC0.94950227
57ZAP700.94410946
58TAOK30.91898149
59JAK20.91732975
60MKNK20.91653787
61MARK10.91237001
62TRIB30.90596769
63PASK0.87749470
64ARAF0.87107557
65CAMKK20.86932390
66SGK30.85910842
67MAP3K10.84738214
68CSNK1G10.84729022
69FGR0.84450213
70LYN0.83447279
71ALK0.82978086
72MAPK110.81798329
73RIPK10.81403509
74CSNK1G20.80519772
75ICK0.79472515
76GRK60.78850195
77SCYL20.78808894
78MARK20.78374173
79TIE10.78032592
80MST40.77649982
81CDK50.77060444
82IKBKB0.75592708
83MAP3K110.75393538
84PRKD30.75243382
85IRAK20.75213512
86MAPK130.75153214
87MAPKAPK50.74215648
88TNK20.72818178
89NTRK10.72448465
90GRK50.71207212
91CAMK2A0.68508727
92CAMK2D0.67392764
93PNCK0.66336539
94PRKCH0.65677757
95MAP2K70.65356151
96PRKCQ0.64123657
97TAOK20.64118291
98STK110.64003488
99NTRK20.62897279
100CSF1R0.62778962
101YES10.62675728
102KIT0.61749929
103IRAK10.58847754
104HIPK20.58786964
105MAP2K30.58751392
106DYRK20.58673069
107DAPK10.58127247
108MAP3K140.58125983
109PINK10.57267435
110MET0.56816786
111PIM10.55007120
112LIMK10.52858115
113RET0.52276360
114CDK140.52102159
115BMPR20.51907950
116TESK20.50711625
117CAMK2G0.50194275
118CAMK40.49382481
119CDC42BPA0.49337527
120MAP3K70.48975493
121PAK30.48701902
122MUSK0.48450568
123PRKCE0.47671985
124CDK40.47637765
125CAMK10.47425594
126BRD40.47200395
127CDK150.47055194
128MAPK100.46710233
129CDK180.46422197
130MAPK40.46283439
131PBK0.46111598
132DYRK1A0.45863196
133KDR0.45712013
134TLK10.42559251
135AKT30.42526680
136MKNK10.41615720
137PHKG20.41585302
138PHKG10.41585302
139CDK11A0.40947798
140FYN0.40619399
141TRPM70.40229234
142CSNK1A10.39916055
143SGK10.39268057
144PRKG10.39025406
145RAF10.37436512
146PDPK10.37364474
147CHUK0.37333040
148MARK30.35921856
149TXK0.35762094
150MAPK70.35616399
151ADRBK20.35611653
152CSK0.35020357
153GRK70.32982520
154INSR0.32389972
155CSNK1D0.32360527
156ITK0.29619812
157ROCK10.28901827
158GSK3A0.28302726
159BMPR1B0.27410390
160SGK20.27391205
161MINK10.26647489
162PRKCG0.26125111
163IRAK40.25893554
164PLK20.25749432
165PRKACA0.24811853
166STK160.24266581
167PDK10.22883193

Predicted pathways (KEGG)

RankGene SetZ-score
1Taurine and hypotaurine metabolism_Homo sapiens_hsa004303.38755238
2Terpenoid backbone biosynthesis_Homo sapiens_hsa009003.20627583
3Fatty acid elongation_Homo sapiens_hsa000622.77977947
4Steroid biosynthesis_Homo sapiens_hsa001002.64074643
5Graft-versus-host disease_Homo sapiens_hsa053322.49808662
6Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.46770100
7Intestinal immune network for IgA production_Homo sapiens_hsa046722.41875322
8Nicotine addiction_Homo sapiens_hsa050332.35683452
9Ether lipid metabolism_Homo sapiens_hsa005652.33650560
10Glutamatergic synapse_Homo sapiens_hsa047242.25473748
11Axon guidance_Homo sapiens_hsa043602.24933601
12Morphine addiction_Homo sapiens_hsa050322.21877758
13Vitamin B6 metabolism_Homo sapiens_hsa007502.19593752
14GABAergic synapse_Homo sapiens_hsa047272.10571106
15Type I diabetes mellitus_Homo sapiens_hsa049402.06061967
16Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.99265449
17Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.94926239
18Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.84989589
19Serotonergic synapse_Homo sapiens_hsa047261.80842237
20Asthma_Homo sapiens_hsa053101.76583821
21Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.76310925
22Leishmaniasis_Homo sapiens_hsa051401.75236623
23Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.75165119
24Sphingolipid metabolism_Homo sapiens_hsa006001.70255727
25Circadian entrainment_Homo sapiens_hsa047131.67455267
26Long-term depression_Homo sapiens_hsa047301.62653919
27Osteoclast differentiation_Homo sapiens_hsa043801.54121091
28NF-kappa B signaling pathway_Homo sapiens_hsa040641.51998139
29Olfactory transduction_Homo sapiens_hsa047401.51160804
30Salivary secretion_Homo sapiens_hsa049701.49169080
31Taste transduction_Homo sapiens_hsa047421.48361192
32Viral myocarditis_Homo sapiens_hsa054161.46079209
33Measles_Homo sapiens_hsa051621.45323523
34Antigen processing and presentation_Homo sapiens_hsa046121.42315520
35Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.41768483
36Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.41524000
37Synaptic vesicle cycle_Homo sapiens_hsa047211.41244830
38Cholinergic synapse_Homo sapiens_hsa047251.37452878
39Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.34685928
40Toll-like receptor signaling pathway_Homo sapiens_hsa046201.33892761
41Long-term potentiation_Homo sapiens_hsa047201.30443050
42Phototransduction_Homo sapiens_hsa047441.28986228
43Dopaminergic synapse_Homo sapiens_hsa047281.27696844
44Non-small cell lung cancer_Homo sapiens_hsa052231.27268488
45Neurotrophin signaling pathway_Homo sapiens_hsa047221.26774712
46Cocaine addiction_Homo sapiens_hsa050301.26411672
47Acute myeloid leukemia_Homo sapiens_hsa052211.23560914
48Collecting duct acid secretion_Homo sapiens_hsa049661.22842240
49Amphetamine addiction_Homo sapiens_hsa050311.21901111
50Influenza A_Homo sapiens_hsa051641.21412012
51VEGF signaling pathway_Homo sapiens_hsa043701.21316349
52Phospholipase D signaling pathway_Homo sapiens_hsa040721.20939876
53Toxoplasmosis_Homo sapiens_hsa051451.19511827
54Gastric acid secretion_Homo sapiens_hsa049711.18581779
55Tuberculosis_Homo sapiens_hsa051521.14945844
56Phosphatidylinositol signaling system_Homo sapiens_hsa040701.13847457
57Gap junction_Homo sapiens_hsa045401.13441171
58Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.12950640
59SNARE interactions in vesicular transport_Homo sapiens_hsa041301.11312665
60Glioma_Homo sapiens_hsa052141.09891043
61Vibrio cholerae infection_Homo sapiens_hsa051101.07751379
62Ras signaling pathway_Homo sapiens_hsa040141.07683491
63Herpes simplex infection_Homo sapiens_hsa051681.05650033
64Hepatitis B_Homo sapiens_hsa051611.05444067
65Oxidative phosphorylation_Homo sapiens_hsa001901.04037581
66ErbB signaling pathway_Homo sapiens_hsa040121.02921662
67RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.02558221
68Renin secretion_Homo sapiens_hsa049241.02402513
69Dorso-ventral axis formation_Homo sapiens_hsa043201.01343256
70Vascular smooth muscle contraction_Homo sapiens_hsa042700.98515303
71Renal cell carcinoma_Homo sapiens_hsa052110.95960530
72Chronic myeloid leukemia_Homo sapiens_hsa052200.95665132
73Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.93945460
74T cell receptor signaling pathway_Homo sapiens_hsa046600.91948398
75Jak-STAT signaling pathway_Homo sapiens_hsa046300.91807677
76Sphingolipid signaling pathway_Homo sapiens_hsa040710.91317701
77Autoimmune thyroid disease_Homo sapiens_hsa053200.91200120
78TNF signaling pathway_Homo sapiens_hsa046680.91109987
79Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.88669136
80Calcium signaling pathway_Homo sapiens_hsa040200.88616196
81Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.88310630
82Hematopoietic cell lineage_Homo sapiens_hsa046400.86966565
83Rheumatoid arthritis_Homo sapiens_hsa053230.86224985
84Staphylococcus aureus infection_Homo sapiens_hsa051500.85597221
85Pancreatic cancer_Homo sapiens_hsa052120.85229773
86Ovarian steroidogenesis_Homo sapiens_hsa049130.84421637
87Tight junction_Homo sapiens_hsa045300.84167979
88Epstein-Barr virus infection_Homo sapiens_hsa051690.83278832
89Prolactin signaling pathway_Homo sapiens_hsa049170.83208463
90cAMP signaling pathway_Homo sapiens_hsa040240.82871518
91Choline metabolism in cancer_Homo sapiens_hsa052310.82329782
92Inositol phosphate metabolism_Homo sapiens_hsa005620.82189965
93Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.81837877
94Oxytocin signaling pathway_Homo sapiens_hsa049210.81604500
95Chemokine signaling pathway_Homo sapiens_hsa040620.81394582
96Apoptosis_Homo sapiens_hsa042100.81089240
97Carbohydrate digestion and absorption_Homo sapiens_hsa049730.80504765
98Hepatitis C_Homo sapiens_hsa051600.79576773
99Alzheimers disease_Homo sapiens_hsa050100.77740597
100MAPK signaling pathway_Homo sapiens_hsa040100.77281112
101Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.76794397
102Leukocyte transendothelial migration_Homo sapiens_hsa046700.76267225
103Platelet activation_Homo sapiens_hsa046110.75991634
104Endocytosis_Homo sapiens_hsa041440.75975168
105AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.74283857
106Regulation of actin cytoskeleton_Homo sapiens_hsa048100.73324240
107Wnt signaling pathway_Homo sapiens_hsa043100.72927449
108Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.72227166
109Aldosterone synthesis and secretion_Homo sapiens_hsa049250.71359514
110mTOR signaling pathway_Homo sapiens_hsa041500.71154703
111Type II diabetes mellitus_Homo sapiens_hsa049300.69810851
112Parkinsons disease_Homo sapiens_hsa050120.69337868
113HTLV-I infection_Homo sapiens_hsa051660.68736542
114Melanogenesis_Homo sapiens_hsa049160.67179484
115B cell receptor signaling pathway_Homo sapiens_hsa046620.67056495
116Endometrial cancer_Homo sapiens_hsa052130.65858478
117Colorectal cancer_Homo sapiens_hsa052100.64822130
118Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.63750216
119Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.63510715
120NOD-like receptor signaling pathway_Homo sapiens_hsa046210.63128418
121HIF-1 signaling pathway_Homo sapiens_hsa040660.62916127
122Linoleic acid metabolism_Homo sapiens_hsa005910.62740148
123Thyroid hormone signaling pathway_Homo sapiens_hsa049190.62295166
124Pancreatic secretion_Homo sapiens_hsa049720.60634084
125Insulin secretion_Homo sapiens_hsa049110.60556311
126Viral carcinogenesis_Homo sapiens_hsa052030.59283035
127GnRH signaling pathway_Homo sapiens_hsa049120.57775232
128alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.56893863
129Sulfur metabolism_Homo sapiens_hsa009200.56810060
130Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.54196756
131Protein export_Homo sapiens_hsa030600.52387744
132Hedgehog signaling pathway_Homo sapiens_hsa043400.49464371
133Rap1 signaling pathway_Homo sapiens_hsa040150.49393452
134Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.48879731
135Primary immunodeficiency_Homo sapiens_hsa053400.47416161
136Histidine metabolism_Homo sapiens_hsa003400.46938479
137Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.46643672
138Arachidonic acid metabolism_Homo sapiens_hsa005900.45200597
139Butanoate metabolism_Homo sapiens_hsa006500.43873781
140Arginine and proline metabolism_Homo sapiens_hsa003300.41334293
141Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.39546648
142Estrogen signaling pathway_Homo sapiens_hsa049150.38685025
143Glycerophospholipid metabolism_Homo sapiens_hsa005640.37050084
144Cardiac muscle contraction_Homo sapiens_hsa042600.36261268
145Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.35976351
146cGMP-PKG signaling pathway_Homo sapiens_hsa040220.35830137
147PI3K-Akt signaling pathway_Homo sapiens_hsa041510.30308054
148Allograft rejection_Homo sapiens_hsa053300.29281989
149Phagosome_Homo sapiens_hsa041450.29240227
150Alcoholism_Homo sapiens_hsa050340.28887471

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »