PPP1R17

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is found primarily in cerebellar Purkinje cells, where it functions as a protein phosphatase inhibitor. The encoded protein is a substrate for cGMP-dependent protein kinase. An allele of this gene was discovered that increases susceptibility to hypercholesterolemia. Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cerebellar granule cell differentiation (GO:0021707)9.58628640
2response to pheromone (GO:0019236)8.64947838
3pyrimidine nucleobase catabolic process (GO:0006208)7.60041158
4cerebellar Purkinje cell differentiation (GO:0021702)7.04323587
5cell differentiation in hindbrain (GO:0021533)6.72462475
6neuronal action potential propagation (GO:0019227)6.65692257
7G-protein coupled glutamate receptor signaling pathway (GO:0007216)6.45604852
8locomotory exploration behavior (GO:0035641)6.27027827
9gamma-aminobutyric acid transport (GO:0015812)6.11277634
10behavioral response to nicotine (GO:0035095)5.93440111
11nucleobase catabolic process (GO:0046113)5.90967244
12cellular potassium ion homeostasis (GO:0030007)5.90230908
13ionotropic glutamate receptor signaling pathway (GO:0035235)5.86255632
14glutamate receptor signaling pathway (GO:0007215)5.79360757
15positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.66309329
16sodium ion export (GO:0071436)5.44784370
17short-term memory (GO:0007614)5.39909932
18regulation of short-term neuronal synaptic plasticity (GO:0048172)5.31912889
19synaptic transmission, glutamatergic (GO:0035249)5.30417765
20neurofilament cytoskeleton organization (GO:0060052)5.22720565
21gamma-aminobutyric acid signaling pathway (GO:0007214)5.21645509
22axonal fasciculation (GO:0007413)5.19267930
23synaptic vesicle maturation (GO:0016188)5.09402615
24regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)4.99973614
25positive regulation of potassium ion transmembrane transporter activity (GO:1901018)4.94260856
26C4-dicarboxylate transport (GO:0015740)4.93871854
27neurotransmitter secretion (GO:0007269)4.87606484
28positive regulation of mitochondrial fission (GO:0090141)4.64906409
29central nervous system projection neuron axonogenesis (GO:0021952)4.62077479
30establishment of mitochondrion localization (GO:0051654)4.59449183
31synaptic vesicle exocytosis (GO:0016079)4.56725515
32protein localization to synapse (GO:0035418)4.54586891
33neuron-neuron synaptic transmission (GO:0007270)4.54093256
34cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.49694132
35positive regulation of dendritic spine morphogenesis (GO:0061003)4.49021805
36neuromuscular process controlling posture (GO:0050884)4.48366058
37regulation of collateral sprouting (GO:0048670)4.48316764
38positive regulation of synapse maturation (GO:0090129)4.47972561
39regulation of synaptic vesicle exocytosis (GO:2000300)4.42499746
40positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.41078604
41vocalization behavior (GO:0071625)4.36946078
42retinal ganglion cell axon guidance (GO:0031290)4.30339830
43regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.25814912
44neuron recognition (GO:0008038)4.24870151
45membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.23357173
46long-term memory (GO:0007616)4.22782469
47mitochondrion transport along microtubule (GO:0047497)4.22419103
48establishment of mitochondrion localization, microtubule-mediated (GO:0034643)4.22419103
49potassium ion import (GO:0010107)4.17296113
50glutamate secretion (GO:0014047)4.08751297
51musculoskeletal movement (GO:0050881)4.04939605
52multicellular organismal movement (GO:0050879)4.04939605
53dendritic spine morphogenesis (GO:0060997)4.00373976
54cell communication by electrical coupling (GO:0010644)3.99205230
55adult walking behavior (GO:0007628)3.91903830
56neurotransmitter transport (GO:0006836)3.91201122
57negative regulation of axon guidance (GO:1902668)3.89266547
58exploration behavior (GO:0035640)3.87405931
59regulation of synaptic vesicle transport (GO:1902803)3.85472908
60retinal cone cell development (GO:0046549)3.84903758
61regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.84529796
62olfactory bulb development (GO:0021772)3.82546436
63potassium ion homeostasis (GO:0055075)3.82166327
64transmission of nerve impulse (GO:0019226)3.80720879
65positive regulation of potassium ion transmembrane transport (GO:1901381)3.80642314
66membrane depolarization during action potential (GO:0086010)3.78111496
67regulation of voltage-gated calcium channel activity (GO:1901385)3.77767025
68negative regulation of synaptic transmission, GABAergic (GO:0032229)3.70889965
69proline transport (GO:0015824)3.69888079
70neuromuscular process controlling balance (GO:0050885)3.68269927
71substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.67934824
72substrate-independent telencephalic tangential migration (GO:0021826)3.67934824
73neuron cell-cell adhesion (GO:0007158)3.67728805
74regulation of excitatory postsynaptic membrane potential (GO:0060079)3.67594652
75regulation of neurotransmitter levels (GO:0001505)3.67518586
76negative regulation of dendrite development (GO:2000171)3.67421596
77regulation of synapse maturation (GO:0090128)3.61889079
78layer formation in cerebral cortex (GO:0021819)3.61886771
79regulation of beta-amyloid formation (GO:1902003)3.61123642
80central nervous system neuron axonogenesis (GO:0021955)3.61001830
81mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)3.58626558
82positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021103.58626558
83cellular sodium ion homeostasis (GO:0006883)3.57453738
84negative regulation of hormone metabolic process (GO:0032351)3.52600837
85negative regulation of hormone biosynthetic process (GO:0032353)3.52600837
86negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.52414157
87glycine transport (GO:0015816)3.50767014
88positive regulation of heat generation (GO:0031652)3.49934697
89synaptic vesicle endocytosis (GO:0048488)3.42803224
90acidic amino acid transport (GO:0015800)3.41740387
91neuronal ion channel clustering (GO:0045161)3.41144370
92mechanosensory behavior (GO:0007638)3.40683877
93regulation of postsynaptic membrane potential (GO:0060078)3.40601212
94protein polyglutamylation (GO:0018095)3.40090577
95negative regulation of catecholamine secretion (GO:0033604)3.39477047
96prepulse inhibition (GO:0060134)3.38651890
97membrane depolarization (GO:0051899)3.38308999
98presynaptic membrane organization (GO:0097090)3.38220735
99response to auditory stimulus (GO:0010996)3.36465509
100regulation of glutamate receptor signaling pathway (GO:1900449)3.36202069
101auditory behavior (GO:0031223)3.35245238
102regulation of neurotransmitter secretion (GO:0046928)3.34874110
103positive regulation of synapse assembly (GO:0051965)3.34769585
104L-glutamate transport (GO:0015813)3.31474176
105presynaptic membrane assembly (GO:0097105)3.30678734
106regulation of synapse structural plasticity (GO:0051823)3.30445046
107dendrite morphogenesis (GO:0048813)3.30371437
108establishment of nucleus localization (GO:0040023)3.29879430
109regulation of heat generation (GO:0031650)3.29818589
110neurotransmitter-gated ion channel clustering (GO:0072578)3.26039855
111synaptic vesicle docking involved in exocytosis (GO:0016081)3.25503674
112negative regulation of axonogenesis (GO:0050771)3.24808402
113calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)3.21936333
114dendrite development (GO:0016358)3.21260600
115synaptic transmission, cholinergic (GO:0007271)3.20895511
116negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.20744034
117postsynaptic membrane organization (GO:0001941)3.19129759
118peristalsis (GO:0030432)3.16696445
119positive regulation of membrane potential (GO:0045838)3.16481392
120regulation of long-term neuronal synaptic plasticity (GO:0048169)3.16233774
121regulation of glucocorticoid secretion (GO:2000849)3.16171286
122regulation of mitochondrial fission (GO:0090140)3.15330535
123regulation of cell communication by electrical coupling (GO:0010649)3.15267618
124spinal cord development (GO:0021510)3.13292084
125response to histamine (GO:0034776)3.13014343
126heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0007157)3.12903023
127regulation of amyloid precursor protein catabolic process (GO:1902991)3.12077994
128relaxation of cardiac muscle (GO:0055119)3.11775452
129synapse assembly (GO:0007416)3.11619623
130regulation of fever generation (GO:0031620)3.11502020
131positive regulation of potassium ion transport (GO:0043268)3.10614177
132cerebral cortex radially oriented cell migration (GO:0021799)3.10472488
133cerebellar Purkinje cell layer development (GO:0021680)3.09976492
134negative regulation of cytosolic calcium ion concentration (GO:0051481)3.09521186
135neuromuscular synaptic transmission (GO:0007274)3.08258488
136membrane hyperpolarization (GO:0060081)3.07798494
137regulation of calcium ion-dependent exocytosis (GO:0017158)3.07227494
138regulation of vesicle fusion (GO:0031338)3.06615791
139membrane repolarization (GO:0086009)3.04449531
140detection of calcium ion (GO:0005513)3.03723588
141hippocampus development (GO:0021766)3.03624707
142regulation of neurotransmitter transport (GO:0051588)3.03368817
143positive regulation of amino acid transport (GO:0051957)3.02683015
144neuron projection extension involved in neuron projection guidance (GO:1902284)3.02009482
145axon extension involved in axon guidance (GO:0048846)3.02009482
146regulation of synaptic transmission, glutamatergic (GO:0051966)3.01291763
147protein localization to cilium (GO:0061512)3.01002644
148regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.99684177
149synapse organization (GO:0050808)2.98629043
150dendritic spine organization (GO:0097061)2.97281266
151negative regulation of axon extension (GO:0030517)2.96888794
152long term synaptic depression (GO:0060292)2.96263362
153neuromuscular process (GO:0050905)2.96228270
154chemosensory behavior (GO:0007635)2.95769683
155gonadal mesoderm development (GO:0007506)2.95521750
156phosphatidylinositol dephosphorylation (GO:0046856)2.93778834
157mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.93596360
158mating behavior (GO:0007617)2.92767615
159regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.91516362
160regulation of dopamine secretion (GO:0014059)2.91177197
161epithelial cilium movement (GO:0003351)2.90971078
162negative regulation of amine transport (GO:0051953)2.90963772
163synaptic transmission (GO:0007268)2.90926997
164positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.90564895
165negative regulation of axon extension involved in axon guidance (GO:0048843)2.90509133
166regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.88561220
167regulation of Rac GTPase activity (GO:0032314)2.84386749
168axon extension (GO:0048675)2.84178763
169regulation of extent of cell growth (GO:0061387)2.82884262
170negative regulation of heart rate (GO:0010459)2.82495051
171neuron migration (GO:0001764)2.79530698
172axonogenesis (GO:0007409)2.78423734

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.09503088
2RBPJ_22232070_ChIP-Seq_NCS_Mouse5.62799352
3SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.60302267
4HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.52451502
5IKZF1_21737484_ChIP-ChIP_HCT116_Human3.19260395
6SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.07036993
7RNF2_18974828_ChIP-Seq_MESCs_Mouse3.00940988
8EZH2_18974828_ChIP-Seq_MESCs_Mouse3.00940988
9JARID2_20064375_ChIP-Seq_MESCs_Mouse2.95720509
10REST_21632747_ChIP-Seq_MESCs_Mouse2.84469761
11SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.75275373
12DROSHA_22980978_ChIP-Seq_HELA_Human2.74773467
13MTF2_20144788_ChIP-Seq_MESCs_Mouse2.70309988
14SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.62573704
15GBX2_23144817_ChIP-Seq_PC3_Human2.61831475
16JARID2_20075857_ChIP-Seq_MESCs_Mouse2.60149984
17EZH2_27294783_Chip-Seq_ESCs_Mouse2.58164561
18TAF15_26573619_Chip-Seq_HEK293_Human2.54331955
19SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.53173055
20SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.52467434
21EED_16625203_ChIP-ChIP_MESCs_Mouse2.51813399
22REST_18959480_ChIP-ChIP_MESCs_Mouse2.28307649
23RNF2_27304074_Chip-Seq_ESCs_Mouse2.27963083
24EZH2_27304074_Chip-Seq_ESCs_Mouse2.23162403
25SUZ12_27294783_Chip-Seq_ESCs_Mouse2.17450969
26EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.12560716
27MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.07951649
28CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.01643418
29RARB_27405468_Chip-Seq_BRAIN_Mouse1.97057890
30ZNF274_21170338_ChIP-Seq_K562_Hela1.92609806
31GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.90371215
32ERG_21242973_ChIP-ChIP_JURKAT_Human1.75846992
33NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.70479489
34VDR_22108803_ChIP-Seq_LS180_Human1.62237274
35SMAD4_21799915_ChIP-Seq_A2780_Human1.61217261
36SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.59535171
37FUS_26573619_Chip-Seq_HEK293_Human1.56279265
38TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.52630499
39THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.52385415
40PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.51087234
41PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.46082508
42SMAD_19615063_ChIP-ChIP_OVARY_Human1.37386670
43AR_21572438_ChIP-Seq_LNCaP_Human1.37201620
44BMI1_23680149_ChIP-Seq_NPCS_Mouse1.36748552
45AR_19668381_ChIP-Seq_PC3_Human1.36632798
46EWS_26573619_Chip-Seq_HEK293_Human1.35169141
47CTBP2_25329375_ChIP-Seq_LNCAP_Human1.34544667
48ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.31618256
49TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.31613369
50RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.26971092
51CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.26636939
52GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22683374
53KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.19862151
54FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.19815745
55DNAJC2_21179169_ChIP-ChIP_NT2_Human1.19232129
56MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.18872671
57CBX2_27304074_Chip-Seq_ESCs_Mouse1.18205192
58AR_25329375_ChIP-Seq_VCAP_Human1.17932943
59UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.17894167
60STAT3_23295773_ChIP-Seq_U87_Human1.17722749
61KDM2B_26808549_Chip-Seq_K562_Human1.17329329
62MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.17272325
63RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.15682361
64IRF1_19129219_ChIP-ChIP_H3396_Human1.15594784
65ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.15270521
66CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.15243019
67PIAS1_25552417_ChIP-Seq_VCAP_Human1.14114195
68SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.13662559
69OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.12843069
70RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.12642161
71PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.12578318
72RING1B_27294783_Chip-Seq_ESCs_Mouse1.11969793
73CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.11946151
74NR3C1_23031785_ChIP-Seq_PC12_Mouse1.10802258
75GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.10420584
76SOX2_21211035_ChIP-Seq_LN229_Gbm1.09322557
77ZFP57_27257070_Chip-Seq_ESCs_Mouse1.09124224
78POU3F2_20337985_ChIP-ChIP_501MEL_Human1.08572403
79CTBP1_25329375_ChIP-Seq_LNCAP_Human1.08321056
80TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.07068645
81P300_19829295_ChIP-Seq_ESCs_Human1.07014531
82IGF1R_20145208_ChIP-Seq_DFB_Human1.05989135
83BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.05159770
84OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.05098360
85SMAD3_21741376_ChIP-Seq_ESCs_Human1.05028522
86RING1B_27294783_Chip-Seq_NPCs_Mouse1.05022098
87CDX2_19796622_ChIP-Seq_MESCs_Mouse1.04751258
88SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.04607971
89TCF4_23295773_ChIP-Seq_U87_Human1.04456892
90MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.03863782
91HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.02401082
92JUN_21703547_ChIP-Seq_K562_Human1.01248149
93SOX9_26525672_Chip-Seq_HEART_Mouse0.99786368
94RNF2_27304074_Chip-Seq_NSC_Mouse0.99388604
95RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.99185654
96TP53_16413492_ChIP-PET_HCT116_Human0.99065385
97RUNX2_22187159_ChIP-Seq_PCA_Human0.98852402
98NR3C1_21868756_ChIP-Seq_MCF10A_Human0.98412666
99ER_23166858_ChIP-Seq_MCF-7_Human0.97195578
100SMAD4_21741376_ChIP-Seq_EPCs_Human0.97005240
101TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.96645264
102POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.96340452
103TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96340452
104WT1_25993318_ChIP-Seq_PODOCYTE_Human0.95913635
105NANOG_18555785_Chip-Seq_ESCs_Mouse0.95579442
106TAL1_26923725_Chip-Seq_HPCs_Mouse0.95477405
107SALL1_21062744_ChIP-ChIP_HESCs_Human0.95425339
108GATA1_26923725_Chip-Seq_HPCs_Mouse0.95147524
109KLF5_20875108_ChIP-Seq_MESCs_Mouse0.95016182
110TP53_22573176_ChIP-Seq_HFKS_Human0.94417822
111TOP2B_26459242_ChIP-Seq_MCF-7_Human0.94305299
112EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.93706618
113PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.93340637
114SMAD4_21741376_ChIP-Seq_HESCs_Human0.93058548
115CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.91115114
116TET1_21490601_ChIP-Seq_MESCs_Mouse0.89834186
117WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.89290471
118RXR_22108803_ChIP-Seq_LS180_Human0.88860828
119ETV2_25802403_ChIP-Seq_MESCs_Mouse0.88594356
120SMAD3_21741376_ChIP-Seq_EPCs_Human0.88279017
121YAP1_20516196_ChIP-Seq_MESCs_Mouse0.87009379
122CBP_20019798_ChIP-Seq_JUKART_Human0.85676842
123TBX3_20139965_ChIP-Seq_MESCs_Mouse0.84942621
124TBX3_20139965_ChIP-Seq_ESCs_Mouse0.84076825
125P53_22127205_ChIP-Seq_FIBROBLAST_Human0.83928070
126TP53_20018659_ChIP-ChIP_R1E_Mouse0.83689901
127TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.83565139
128AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.83286677
129BCAT_22108803_ChIP-Seq_LS180_Human0.83121941
130TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.82399588
131EP300_21415370_ChIP-Seq_HL-1_Mouse0.82101285
132ZNF217_24962896_ChIP-Seq_MCF-7_Human0.81217042
133EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.81126588

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009046_muscle_twitch5.61202245
2MP0002822_catalepsy4.94445185
3MP0004859_abnormal_synaptic_plasticity4.83235090
4MP0003635_abnormal_synaptic_transmissio3.94447540
5MP0008569_lethality_at_weaning3.90117072
6MP0004145_abnormal_muscle_electrophysio3.50843738
7MP0002272_abnormal_nervous_system3.39429918
8MP0002064_seizures3.11725890
9MP0009745_abnormal_behavioral_response3.10082265
10MP0001440_abnormal_grooming_behavior2.85316500
11MP0002067_abnormal_sensory_capabilities2.83210757
12MP0001968_abnormal_touch/_nociception2.78645773
13MP0001529_abnormal_vocalization2.63833385
14MP0002734_abnormal_mechanical_nocicepti2.63662287
15MP0002063_abnormal_learning/memory/cond2.63422837
16MP0004147_increased_porphyrin_level2.53884284
17MP0002653_abnormal_ependyma_morphology2.53743051
18MP0004270_analgesia2.53491052
19MP0002572_abnormal_emotion/affect_behav2.51507112
20MP0002184_abnormal_innervation2.50488725
21MP0005423_abnormal_somatic_nervous2.47034585
22MP0003880_abnormal_central_pattern2.41413128
23MP0004142_abnormal_muscle_tone2.29848064
24MP0002736_abnormal_nociception_after2.27323343
25MP0001501_abnormal_sleep_pattern2.23163360
26MP0001486_abnormal_startle_reflex2.19181576
27MP0002735_abnormal_chemical_nociception2.12270942
28MP0004742_abnormal_vestibular_system2.11398687
29MP0002557_abnormal_social/conspecific_i1.93789667
30MP0002733_abnormal_thermal_nociception1.90858036
31MP0004924_abnormal_behavior1.90807968
32MP0005386_behavior/neurological_phenoty1.90807968
33MP0005645_abnormal_hypothalamus_physiol1.81215519
34MP0004885_abnormal_endolymph1.79906831
35MP0001970_abnormal_pain_threshold1.75561972
36MP0001502_abnormal_circadian_rhythm1.68813493
37MP0003632_abnormal_nervous_system1.67658608
38MP0002066_abnormal_motor_capabilities/c1.63487601
39MP0001984_abnormal_olfaction1.63285549
40MP0004215_abnormal_myocardial_fiber1.54854825
41MP0000955_abnormal_spinal_cord1.53183176
42MP0002254_reproductive_system_inflammat1.52941580
43MP0008877_abnormal_DNA_methylation1.48282935
44MP0003329_amyloid_beta_deposits1.45095821
45MP0003137_abnormal_impulse_conducting1.40751638
46MP0003122_maternal_imprinting1.37149210
47MP0000013_abnormal_adipose_tissue1.35228171
48MP0003011_delayed_dark_adaptation1.33793644
49MP0003631_nervous_system_phenotype1.32770528
50MP0000778_abnormal_nervous_system1.31620015
51MP0002882_abnormal_neuron_morphology1.31611051
52MP0003633_abnormal_nervous_system1.31031717
53MP0005171_absent_coat_pigmentation1.29332153
54MP0000920_abnormal_myelination1.28037261
55MP0003690_abnormal_glial_cell1.26900631
56MP0000569_abnormal_digit_pigmentation1.25786659
57MP0002638_abnormal_pupillary_reflex1.25424682
58MP0004043_abnormal_pH_regulation1.21279887
59MP0008789_abnormal_olfactory_epithelium1.20343679
60MP0004811_abnormal_neuron_physiology1.20013805
61MP0003879_abnormal_hair_cell1.18971439
62MP0002152_abnormal_brain_morphology1.16131993
63MP0001188_hyperpigmentation1.15864502
64MP0003890_abnormal_embryonic-extraembry1.15321883
65MP0006072_abnormal_retinal_apoptosis1.14278325
66MP0005551_abnormal_eye_electrophysiolog1.13154432
67MP0002751_abnormal_autonomic_nervous1.11730412
68MP0002229_neurodegeneration1.11553515
69MP0003861_abnormal_nervous_system1.10808156
70MP0002909_abnormal_adrenal_gland1.06880756
71MP0003787_abnormal_imprinting1.06039434
72MP0006292_abnormal_olfactory_placode1.05034643
73MP0006276_abnormal_autonomic_nervous1.03514639
74MP0004510_myositis1.03184530
75MP0001905_abnormal_dopamine_level1.00732398
76MP0004036_abnormal_muscle_relaxation0.98219125
77MP0008872_abnormal_physiological_respon0.97407750
78MP0000631_abnormal_neuroendocrine_gland0.95424684
79MP0002089_abnormal_postnatal_growth/wei0.90735316
80MP0000751_myopathy0.89234268
81MP0006035_abnormal_mitochondrial_morpho0.88620994
82MP0005083_abnormal_biliary_tract0.88394276
83MP0004085_abnormal_heartbeat0.88331081
84MP0004484_altered_response_of0.87896535
85MP0001963_abnormal_hearing_physiology0.87046049
86MP0004084_abnormal_cardiac_muscle0.84603076
87MP0001485_abnormal_pinna_reflex0.82869320
88MP0000538_abnormal_urinary_bladder0.82250010
89MP0008874_decreased_physiological_sensi0.82043189
90MP0003221_abnormal_cardiomyocyte_apopto0.80334285
91MP0005195_abnormal_posterior_eye0.79942630
92MP0001299_abnormal_eye_distance/0.78079545
93MP0004858_abnormal_nervous_system0.77610096
94MP0002069_abnormal_eating/drinking_beha0.76082369
95MP0003634_abnormal_glial_cell0.76026647
96MP0002752_abnormal_somatic_nervous0.74508448
97MP0008875_abnormal_xenobiotic_pharmacok0.72822332
98MP0003718_maternal_effect0.69403594
99MP0004233_abnormal_muscle_weight0.68975075
100MP0010769_abnormal_survival0.68107573
101MP0004133_heterotaxia0.66760798
102MP0003123_paternal_imprinting0.65801630
103MP0010768_mortality/aging0.65429982
104MP0010770_preweaning_lethality0.64024638
105MP0002082_postnatal_lethality0.64024638
106MP0005391_vision/eye_phenotype0.63827636
107MP0005084_abnormal_gallbladder_morpholo0.63809465
108MP0003121_genomic_imprinting0.62561100
109MP0002938_white_spotting0.62233560
110MP0002081_perinatal_lethality0.60803214
111MP0003283_abnormal_digestive_organ0.60261841
112MP0005499_abnormal_olfactory_system0.59834622
113MP0005394_taste/olfaction_phenotype0.59834622
114MP0000747_muscle_weakness0.59757974
115MP0000604_amyloidosis0.58737052
116MP0000534_abnormal_ureter_morphology0.58562023
117MP0005646_abnormal_pituitary_gland0.58380001
118MP0005187_abnormal_penis_morphology0.58203664
119MP0005253_abnormal_eye_physiology0.57763558
120MP0005535_abnormal_body_temperature0.56441720
121MP0008995_early_reproductive_senescence0.56279965
122MP0010386_abnormal_urinary_bladder0.56090163
123MP0003698_abnormal_male_reproductive0.55107752
124MP0003646_muscle_fatigue0.54285842
125MP0008770_decreased_survivor_rate0.53624081
126MP0003567_abnormal_fetal_cardiomyocyte0.52880758
127MP0001177_atelectasis0.52832366
128MP0001943_abnormal_respiration0.52691834
129MP0003956_abnormal_body_size0.52029607

Predicted human phenotypes

RankGene SetZ-score
1Progressive cerebellar ataxia (HP:0002073)7.89457091
2Action tremor (HP:0002345)7.60375071
3Gaze-evoked nystagmus (HP:0000640)6.07200879
4Focal motor seizures (HP:0011153)6.01807691
5Scanning speech (HP:0002168)5.82297194
6Visual hallucinations (HP:0002367)5.79969333
7Atonic seizures (HP:0010819)5.66753720
8Myokymia (HP:0002411)5.51650480
9Dysdiadochokinesis (HP:0002075)5.39849456
10Febrile seizures (HP:0002373)5.37353750
11Focal seizures (HP:0007359)5.08098709
12Dysmetric saccades (HP:0000641)4.98860512
13Impaired smooth pursuit (HP:0007772)4.88386314
14Intention tremor (HP:0002080)4.64946554
15Hemiplegia (HP:0002301)4.59978752
16Abnormality of ocular smooth pursuit (HP:0000617)4.52534172
17Epileptic encephalopathy (HP:0200134)4.37588798
18Dysmetria (HP:0001310)4.32568471
19Absence seizures (HP:0002121)4.31786321
20Broad-based gait (HP:0002136)4.23455270
21Abnormality of binocular vision (HP:0011514)4.04054024
22Diplopia (HP:0000651)4.04054024
23Truncal ataxia (HP:0002078)3.96188962
24Cortical dysplasia (HP:0002539)3.95827644
25Genetic anticipation (HP:0003743)3.82906241
26Amblyopia (HP:0000646)3.82133309
27Tetraplegia (HP:0002445)3.81238341
28Hemiparesis (HP:0001269)3.73592924
29Horizontal nystagmus (HP:0000666)3.72887528
30Postural tremor (HP:0002174)3.67475602
31Dialeptic seizures (HP:0011146)3.67080201
32Polyphagia (HP:0002591)3.65528079
33Gait imbalance (HP:0002141)3.55593196
34Hypoplasia of the brainstem (HP:0002365)3.48965509
35Aplasia/Hypoplasia of the brainstem (HP:0007362)3.48965509
36Wrist flexion contracture (HP:0001239)3.47637317
37Status epilepticus (HP:0002133)3.39068892
38Exotropia (HP:0000577)3.36348223
39Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.34079184
40Degeneration of the lateral corticospinal tracts (HP:0002314)3.34079184
41Abnormality of saccadic eye movements (HP:0000570)3.32690933
42Generalized tonic-clonic seizures (HP:0002069)3.27426547
43Poor eye contact (HP:0000817)3.15228189
44Abnormality of the lower motor neuron (HP:0002366)3.11021922
45Congenital primary aphakia (HP:0007707)3.04683871
46Limb ataxia (HP:0002070)3.02849203
47Ventricular fibrillation (HP:0001663)2.94497654
48Medial flaring of the eyebrow (HP:0010747)2.93900699
49Depression (HP:0000716)2.92249352
50Abnormal eating behavior (HP:0100738)2.88994391
51Annular pancreas (HP:0001734)2.88075886
52Anxiety (HP:0000739)2.87897380
53Lissencephaly (HP:0001339)2.86537159
54Nephrogenic diabetes insipidus (HP:0009806)2.80266298
55Abnormal social behavior (HP:0012433)2.71671302
56Impaired social interactions (HP:0000735)2.71671302
57Oligodactyly (hands) (HP:0001180)2.67129967
58Agitation (HP:0000713)2.59764849
59Gait ataxia (HP:0002066)2.58083829
60Limb dystonia (HP:0002451)2.57063395
61Abnormality of the corticospinal tract (HP:0002492)2.55935438
62Intestinal atresia (HP:0011100)2.49782275
63Bundle branch block (HP:0011710)2.49069264
64Vaginal atresia (HP:0000148)2.48796133
65Myotonia (HP:0002486)2.46582027
66Lower limb asymmetry (HP:0100559)2.44405154
67Genital tract atresia (HP:0001827)2.43551502
68Pheochromocytoma (HP:0002666)2.41888685
69Impaired vibration sensation in the lower limbs (HP:0002166)2.41104056
70Amyotrophic lateral sclerosis (HP:0007354)2.40955811
71Pachygyria (HP:0001302)2.38148136
72True hermaphroditism (HP:0010459)2.37857818
73Spinal canal stenosis (HP:0003416)2.34521881
74Polymicrogyria (HP:0002126)2.33294655
75Psychosis (HP:0000709)2.33095208
76Pancreatic cysts (HP:0001737)2.32778931
77Pancreatic fibrosis (HP:0100732)2.32735507
78Abnormality of the labia minora (HP:0012880)2.32178917
79Slow progression (HP:0003677)2.29249151
80Autoamputation (HP:0001218)2.26044500
81Morphological abnormality of the pyramidal tract (HP:0002062)2.23476927
82Confusion (HP:0001289)2.22567450
83Atrophy/Degeneration involving motor neurons (HP:0007373)2.17633705
84Split foot (HP:0001839)2.15984487
85Nephronophthisis (HP:0000090)2.14239350
86Spastic gait (HP:0002064)2.13343355
87Neuroendocrine neoplasm (HP:0100634)2.12118875
88Hyperventilation (HP:0002883)2.10288287
89Volvulus (HP:0002580)2.09882089
90Supranuclear gaze palsy (HP:0000605)2.09198282
91Molar tooth sign on MRI (HP:0002419)2.07988142
92Abnormality of midbrain morphology (HP:0002418)2.07988142
93Narrow nasal bridge (HP:0000446)2.07832831
94Postural instability (HP:0002172)2.06255005
95Poor coordination (HP:0002370)2.05502893
96Urinary urgency (HP:0000012)2.05428069
97Lower limb muscle weakness (HP:0007340)2.04402206
98Inability to walk (HP:0002540)2.01529259
99Incomplete penetrance (HP:0003829)2.01120850
100Stereotypic behavior (HP:0000733)1.99338964
101Hypoplasia of the corpus callosum (HP:0002079)1.98851522
102Mutism (HP:0002300)1.98671212
103Esotropia (HP:0000565)1.93671172
104Hypoplastic nipples (HP:0002557)1.92803890
105Tubulointerstitial abnormality (HP:0001969)1.92673797
106Fetal akinesia sequence (HP:0001989)1.91639645
107Tubulointerstitial nephritis (HP:0001970)1.91113009
108Pointed chin (HP:0000307)1.90269217
1093-Methylglutaconic aciduria (HP:0003535)1.88688469
110Neuronal loss in central nervous system (HP:0002529)1.86844528
111Sleep apnea (HP:0010535)1.86768186
112Cerebellar atrophy (HP:0001272)1.85895930
113Broad foot (HP:0001769)1.85572632
114Spastic tetraplegia (HP:0002510)1.85154061
115Postaxial hand polydactyly (HP:0001162)1.84887087
116Intellectual disability, moderate (HP:0002342)1.84139235
117Broad metatarsal (HP:0001783)1.81974893
118Focal dystonia (HP:0004373)1.81615803
119Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.80104861
120Drooling (HP:0002307)1.78935664
121Excessive salivation (HP:0003781)1.78935664
122EEG with generalized epileptiform discharges (HP:0011198)1.78893581
123Synostosis involving the elbow (HP:0003938)1.78429182
124Humeroradial synostosis (HP:0003041)1.78429182
125Muscular hypotonia of the trunk (HP:0008936)1.77015829
126Exercise-induced myalgia (HP:0003738)1.75177443
127Epidermoid cyst (HP:0200040)1.75075891
128Abnormality of the motor neurons (HP:0002450)1.74745167
129Abnormal neuron morphology (HP:0012757)1.74745167
130Epileptiform EEG discharges (HP:0011182)1.74498768
131Nonprogressive disorder (HP:0003680)1.72370273
132Abnormality of macular pigmentation (HP:0008002)1.70315848
133Impaired vibratory sensation (HP:0002495)1.70185187
134Optic nerve hypoplasia (HP:0000609)1.69381741
135Tubulointerstitial fibrosis (HP:0005576)1.68969582
136Poor suck (HP:0002033)1.68954421
137Hypsarrhythmia (HP:0002521)1.65275535
138Dysarthria (HP:0001260)1.64779629
139Oligodactyly (HP:0012165)1.64540651
140Specific learning disability (HP:0001328)1.63885321
141Progressive inability to walk (HP:0002505)1.63318639
142Megalencephaly (HP:0001355)1.62956320
143Abnormal EKG (HP:0003115)1.59741801
144Prolonged QT interval (HP:0001657)1.59267260
145Abnormal hair whorl (HP:0010721)1.58407163
146Clonus (HP:0002169)1.57599251
147Retinal dysplasia (HP:0007973)1.56775251
148Ankle clonus (HP:0011448)1.56041170
149Absent speech (HP:0001344)1.55649192
150Urinary bladder sphincter dysfunction (HP:0002839)1.55006355
151Bradykinesia (HP:0002067)1.54654588
152Tinnitus (HP:0000360)1.49135428
153Failure to thrive in infancy (HP:0001531)1.48713742
154Aqueductal stenosis (HP:0002410)1.46819328

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CAMKK25.17664007
2EPHA34.81515615
3RIPK13.54263372
4NTRK33.31437509
5TRIM283.24240021
6WNK13.10331785
7MAP3K42.95296768
8CAMKK12.63739149
9CDK192.56214026
10DYRK22.53469307
11MAP2K72.52157199
12NTRK22.43738540
13MINK12.34585002
14MAP2K42.32057423
15MAP4K22.27625437
16MAP3K92.19894005
17PNCK2.17408712
18TNIK2.03767591
19STK382.02938537
20MARK11.97267730
21PAK61.90441456
22DYRK31.82446733
23PRPF4B1.82073884
24CSNK1G21.81038886
25PRKCG1.79424703
26PINK11.73148093
27CSNK1G31.71815807
28DYRK1B1.66307081
29EPHA41.62749900
30CSNK1A1L1.62367474
31WNK31.61673667
32OXSR11.56495442
33DAPK21.56173098
34STK161.48003782
35UHMK11.44707552
36RIPK41.43770820
37SGK2231.41252250
38SGK4941.41252250
39PTK61.39515457
40SGK21.37388843
41CSNK1G11.30316955
42TYRO31.27839571
43CAMK2G1.19353503
44CAMK11.17794498
45MAPK131.15940862
46MAP3K61.15388216
47CDC42BPA1.14981769
48CAMK1G1.11300981
49PRKCH1.09729066
50SGK31.08927662
51LIMK11.08101772
52ERBB31.07739129
53STK111.07503600
54CAMK41.07286965
55GRK51.05473349
56CDK51.04221167
57MATK1.02413347
58PLK21.01912394
59EPHB21.01432747
60ALK1.00389934
61MAPKAPK51.00314709
62CDK150.98928495
63CASK0.97142695
64CDK180.96752427
65CAMK2B0.96581071
66NEK60.96306977
67PRKG10.92462215
68PHKG20.88589512
69PHKG10.88589512
70CAMK2D0.88544684
71BMPR20.87210505
72CDK11A0.86588427
73CDK140.84447086
74CAMK2A0.81938704
75TESK10.80766713
76ROCK20.79582759
77SRPK10.78046723
78DYRK1A0.77928832
79PDK10.75780456
80MAP3K120.73738908
81OBSCN0.69314129
82ERBB20.68867691
83SGK10.66660613
84SIK20.64490208
85EPHB10.63630827
86BCR0.62997489
87HIPK20.61551256
88RPS6KA30.60816906
89CSNK1A10.56520465
90* PRKACA0.55336612
91FYN0.54873527
92KSR10.54081867
93PRKCZ0.53452720
94BRSK10.52941331
95KSR20.52740986
96AKT30.52274421
97ADRBK20.51751577
98NTRK10.50886533
99PDPK10.50643938
100RPS6KB10.49977913
101PRKDC0.49852301
102GRK10.49813127
103FER0.49572516
104SIK30.48201387
105FES0.47081250
106MAPK120.46851633
107ADRBK10.46818414
108PKN10.46639838
109PRKCA0.45826021
110CSNK1D0.45775104
111PRKACB0.44669026
112SRC0.44594898
113RET0.43980545
114RPS6KA40.43087841
115WNK40.43037881
116TNK20.42957296
117PRKCE0.42369953
118PTK20.41806174
119MAP3K20.41543208
120TAOK20.41523403
121MKNK20.40449734
122PRKAA10.40236545
123MARK20.39324750
124PRKACG0.39193735
125BCKDK0.39104166
126YES10.39040458
127INSRR0.38469539
128CSNK1E0.38146959
129PIK3CA0.36574235
130ICK0.36387423
131MAPK150.36292256
132BMPR1B0.36184399
133MAP3K130.35438019
134RPS6KA20.34984681
135PRKCB0.34588909
136PAK30.33614987
137MAPK100.33184728
138CDK30.32888370
139TESK20.30036477
140VRK10.29979418
141MAPK90.26335121
142PBK0.22406379
143MAPK80.21441470

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.86145372
2Glutamatergic synapse_Homo sapiens_hsa047243.35363973
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047233.31874515
4Long-term potentiation_Homo sapiens_hsa047203.06047991
5GABAergic synapse_Homo sapiens_hsa047273.02792426
6Circadian entrainment_Homo sapiens_hsa047132.92093709
7* Long-term depression_Homo sapiens_hsa047302.82745235
8Taste transduction_Homo sapiens_hsa047422.81163003
9Synaptic vesicle cycle_Homo sapiens_hsa047212.79576836
10Morphine addiction_Homo sapiens_hsa050322.60788533
11Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.31595768
12Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.31423514
13Salivary secretion_Homo sapiens_hsa049702.22670105
14Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.16101588
15Steroid biosynthesis_Homo sapiens_hsa001002.10803806
16Amphetamine addiction_Homo sapiens_hsa050312.09734944
17Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.93829016
18Dopaminergic synapse_Homo sapiens_hsa047281.91661986
19Gastric acid secretion_Homo sapiens_hsa049711.89774644
20Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.88670417
21Aldosterone synthesis and secretion_Homo sapiens_hsa049251.81291899
22Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.76509376
23Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.76068370
24Insulin secretion_Homo sapiens_hsa049111.72840372
25Cardiac muscle contraction_Homo sapiens_hsa042601.71073214
26Olfactory transduction_Homo sapiens_hsa047401.70769126
27Phosphatidylinositol signaling system_Homo sapiens_hsa040701.69220981
28Cholinergic synapse_Homo sapiens_hsa047251.58907800
29Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.56550332
30Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.56423545
31Serotonergic synapse_Homo sapiens_hsa047261.54152485
32Calcium signaling pathway_Homo sapiens_hsa040201.42524114
33Oxytocin signaling pathway_Homo sapiens_hsa049211.41898507
34Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.41360514
35Pancreatic secretion_Homo sapiens_hsa049721.40832493
36Type II diabetes mellitus_Homo sapiens_hsa049301.40596564
37Thyroid hormone synthesis_Homo sapiens_hsa049181.25599177
38Renin secretion_Homo sapiens_hsa049241.23324226
39Gap junction_Homo sapiens_hsa045401.18307109
40cAMP signaling pathway_Homo sapiens_hsa040241.18080447
41Estrogen signaling pathway_Homo sapiens_hsa049151.16386136
42Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.14187893
43GnRH signaling pathway_Homo sapiens_hsa049121.11497432
44Circadian rhythm_Homo sapiens_hsa047101.03457762
45cGMP-PKG signaling pathway_Homo sapiens_hsa040221.02445606
46Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.01804215
47Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.96444037
48Protein export_Homo sapiens_hsa030600.96018053
49Cocaine addiction_Homo sapiens_hsa050300.95981977
50Collecting duct acid secretion_Homo sapiens_hsa049660.95338158
51Inositol phosphate metabolism_Homo sapiens_hsa005620.93586819
52Alzheimers disease_Homo sapiens_hsa050100.92814539
53Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.89122633
54Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.88466184
55Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.86739421
56Carbohydrate digestion and absorption_Homo sapiens_hsa049730.85548734
57Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.85525516
58Dilated cardiomyopathy_Homo sapiens_hsa054140.84567134
59Fatty acid elongation_Homo sapiens_hsa000620.84210150
60Oocyte meiosis_Homo sapiens_hsa041140.83976335
61Regulation of autophagy_Homo sapiens_hsa041400.83680692
62Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.82788514
63Butanoate metabolism_Homo sapiens_hsa006500.80757269
64Melanogenesis_Homo sapiens_hsa049160.80753263
65Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.80356237
66Vascular smooth muscle contraction_Homo sapiens_hsa042700.78707038
67Phospholipase D signaling pathway_Homo sapiens_hsa040720.78139490
68Bile secretion_Homo sapiens_hsa049760.73361472
69Oxidative phosphorylation_Homo sapiens_hsa001900.72072088
70Nitrogen metabolism_Homo sapiens_hsa009100.65835560
71Pyruvate metabolism_Homo sapiens_hsa006200.65655799
72Ether lipid metabolism_Homo sapiens_hsa005650.64513491
73Renin-angiotensin system_Homo sapiens_hsa046140.63370801
74MAPK signaling pathway_Homo sapiens_hsa040100.60105975
75Biosynthesis of amino acids_Homo sapiens_hsa012300.58954289
76Choline metabolism in cancer_Homo sapiens_hsa052310.58749651
77Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.55743897
78Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.54002127
79Fatty acid metabolism_Homo sapiens_hsa012120.52852930
80Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.51909925
81alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.51588851
82Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.51476296
83ErbB signaling pathway_Homo sapiens_hsa040120.51262423
84Arginine and proline metabolism_Homo sapiens_hsa003300.50889044
85Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.50118043
86Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.49382477
87Fructose and mannose metabolism_Homo sapiens_hsa000510.48989655
88Parkinsons disease_Homo sapiens_hsa050120.48367015
89Mineral absorption_Homo sapiens_hsa049780.47061265
90Ras signaling pathway_Homo sapiens_hsa040140.46710735
91Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.45704708
92Huntingtons disease_Homo sapiens_hsa050160.45340271
93Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.41169598
94Glioma_Homo sapiens_hsa052140.41135042
95Linoleic acid metabolism_Homo sapiens_hsa005910.39903178
96Colorectal cancer_Homo sapiens_hsa052100.39727180
97Longevity regulating pathway - mammal_Homo sapiens_hsa042110.39715527
98Axon guidance_Homo sapiens_hsa043600.39634592
99Tryptophan metabolism_Homo sapiens_hsa003800.39040724
100Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.38635733
101Thyroid hormone signaling pathway_Homo sapiens_hsa049190.38193723
102Phagosome_Homo sapiens_hsa041450.37892834
103Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.37501247
104Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.37207159
105Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.37174819
106Histidine metabolism_Homo sapiens_hsa003400.36571914
107mTOR signaling pathway_Homo sapiens_hsa041500.34471594
108Glucagon signaling pathway_Homo sapiens_hsa049220.34316708
109Vibrio cholerae infection_Homo sapiens_hsa051100.34083444
110Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.33170670
111Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.32575272
112Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.31821681
113Sphingolipid signaling pathway_Homo sapiens_hsa040710.31547886
114Hippo signaling pathway_Homo sapiens_hsa043900.29849098
115Maturity onset diabetes of the young_Homo sapiens_hsa049500.29696570
116Carbon metabolism_Homo sapiens_hsa012000.29507839
117Alcoholism_Homo sapiens_hsa050340.29099270
118Neurotrophin signaling pathway_Homo sapiens_hsa047220.29047209
119Wnt signaling pathway_Homo sapiens_hsa043100.28959473
120Phototransduction_Homo sapiens_hsa047440.28576888
121SNARE interactions in vesicular transport_Homo sapiens_hsa041300.27789639
122Dorso-ventral axis formation_Homo sapiens_hsa043200.27761861
123African trypanosomiasis_Homo sapiens_hsa051430.27299599
124Propanoate metabolism_Homo sapiens_hsa006400.27043966
125RNA degradation_Homo sapiens_hsa030180.25924576
126Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.25289922
127Chemokine signaling pathway_Homo sapiens_hsa040620.23788393
128Glycerophospholipid metabolism_Homo sapiens_hsa005640.23625233
129Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.23348995
130Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.22762248
131VEGF signaling pathway_Homo sapiens_hsa043700.21488329
132Hedgehog signaling pathway_Homo sapiens_hsa043400.21120161
133Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.19088221
134Proteoglycans in cancer_Homo sapiens_hsa052050.18262249
135Ovarian steroidogenesis_Homo sapiens_hsa049130.17341042
136Rap1 signaling pathway_Homo sapiens_hsa040150.16208733
137Platelet activation_Homo sapiens_hsa046110.15644265

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