PPP1R1A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1COPI coating of Golgi vesicle (GO:0048205)7.09163161
2Golgi transport vesicle coating (GO:0048200)7.09163161
3actin-myosin filament sliding (GO:0033275)6.49116425
4muscle filament sliding (GO:0030049)6.49116425
5protein maturation by protein folding (GO:0022417)5.96535956
6regulation of sequestering of triglyceride (GO:0010889)5.63641241
7actin-mediated cell contraction (GO:0070252)5.31712644
8creatine metabolic process (GO:0006600)5.04265220
9regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022354.97275279
10endocrine pancreas development (GO:0031018)4.94190740
11skeletal muscle contraction (GO:0003009)4.87448213
12regulation of skeletal muscle contraction (GO:0014819)4.79239267
13peptide hormone processing (GO:0016486)4.61759272
14retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)4.61627726
15fatty acid homeostasis (GO:0055089)4.57793424
16regulation of type B pancreatic cell apoptotic process (GO:2000674)4.57291317
17myofibril assembly (GO:0030239)4.48233832
18maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.47632360
19insulin secretion (GO:0030073)4.43507383
20positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.43448753
21NADH metabolic process (GO:0006734)4.31196505
22positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)4.27317989
23detection of calcium ion (GO:0005513)4.25155692
24protein retention in ER lumen (GO:0006621)4.09084653
25striated muscle contraction (GO:0006941)4.07885225
26regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)4.00591841
27regulation of short-term neuronal synaptic plasticity (GO:0048172)3.94808607
28triglyceride catabolic process (GO:0019433)3.93885894
29COPII vesicle coating (GO:0048208)3.93236916
30nitric oxide mediated signal transduction (GO:0007263)3.91339112
31regulation of insulin secretion (GO:0050796)3.89054964
32regulation of relaxation of muscle (GO:1901077)3.88971427
33fatty acid transmembrane transport (GO:1902001)3.86343132
34glycogen catabolic process (GO:0005980)3.84300209
35synaptic vesicle maturation (GO:0016188)3.83759554
36actin filament-based movement (GO:0030048)3.82632802
37positive regulation of insulin secretion (GO:0032024)3.81607669
38low-density lipoprotein particle clearance (GO:0034383)3.80398025
39response to muscle activity (GO:0014850)3.78841371
40membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.77075249
41glandular epithelial cell differentiation (GO:0002067)3.73659696
42negative regulation of norepinephrine secretion (GO:0010700)3.70062615
43cardiac myofibril assembly (GO:0055003)3.66927903
44sarcomere organization (GO:0045214)3.64512754
45regulation of synaptic vesicle exocytosis (GO:2000300)3.64462474
46negative regulation of catecholamine secretion (GO:0033604)3.61865707
47skeletal muscle fiber development (GO:0048741)3.61262974
48acylglycerol catabolic process (GO:0046464)3.57326951
49neutral lipid catabolic process (GO:0046461)3.57326951
50carnitine shuttle (GO:0006853)3.55985903
51vesicle coating (GO:0006901)3.55427689
52glucan catabolic process (GO:0009251)3.55368507
53neuronal action potential propagation (GO:0019227)3.53709878
54regulation of peptide hormone secretion (GO:0090276)3.53192794
55synaptic vesicle exocytosis (GO:0016079)3.52143776
56regulation of peptide secretion (GO:0002791)3.49618567
57regulation of cell communication by electrical coupling (GO:0010649)3.47266059
58type B pancreatic cell development (GO:0003323)3.45846285
59exocrine pancreas development (GO:0031017)3.42313319
60glucan biosynthetic process (GO:0009250)3.42215492
61glycogen biosynthetic process (GO:0005978)3.42215492
62regulation of oxidative phosphorylation (GO:0002082)3.40829655
63cardiac muscle contraction (GO:0060048)3.39360050
64muscle contraction (GO:0006936)3.38278856
65peptide hormone secretion (GO:0030072)3.38205991
66cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.37774581
67myotube cell development (GO:0014904)3.36017097
68response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.32559541
69activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.30837443
70membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.30098028
71negative regulation of insulin secretion (GO:0046676)3.29446725
72peptide secretion (GO:0002790)3.26841932
73regulation of membrane repolarization (GO:0060306)3.26704968
74cellular polysaccharide catabolic process (GO:0044247)3.26304164
75glandular epithelial cell development (GO:0002068)3.25023834
76lipid particle organization (GO:0034389)3.24418843
77regulation of synaptic vesicle transport (GO:1902803)3.23199880
78cellular response to glucagon stimulus (GO:0071377)3.20433046
79regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.19530259
80cerebellar Purkinje cell layer development (GO:0021680)3.17167452
81negative regulation of phosphoprotein phosphatase activity (GO:0032515)3.16209268
82chemosensory behavior (GO:0007635)3.15278724
83positive regulation of peptide hormone secretion (GO:0090277)3.14606195
84response to inactivity (GO:0014854)3.14568117
85regulation of glycogen (starch) synthase activity (GO:2000465)3.13536505
86positive regulation of peptide secretion (GO:0002793)3.13179158
87positive regulation of nuclease activity (GO:0032075)3.09208482
88regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.09119513
89signal peptide processing (GO:0006465)3.08795483
90glycerolipid catabolic process (GO:0046503)3.08036369
91regulation of hormone secretion (GO:0046883)3.07432954
92brown fat cell differentiation (GO:0050873)3.06612566
93glutamate secretion (GO:0014047)3.06541592
94activation of protein kinase A activity (GO:0034199)3.04552305
95locomotory exploration behavior (GO:0035641)3.03159838
96oxaloacetate metabolic process (GO:0006107)3.02666156
97ER overload response (GO:0006983)3.00200828
98cell communication by electrical coupling (GO:0010644)2.99124547
99muscle system process (GO:0003012)2.98370268
100regulation of calcium ion-dependent exocytosis (GO:0017158)2.98365995
101plasma membrane repair (GO:0001778)2.97009421
102polysaccharide catabolic process (GO:0000272)2.93590092
103negative regulation of peptide hormone secretion (GO:0090278)2.93201604
104membrane repolarization during action potential (GO:0086011)2.92874981
105diacylglycerol metabolic process (GO:0046339)2.90368769
106actomyosin structure organization (GO:0031032)2.89931204
107muscle fiber development (GO:0048747)2.89590433
108regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.88784687
109positive regulation of glycolytic process (GO:0045821)2.88098760
110regulation of norepinephrine secretion (GO:0014061)2.87638958
111positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.87610750
112gluconeogenesis (GO:0006094)2.87077231
113positive regulation of exocytosis (GO:0045921)2.86827906
114regulation of actin filament-based movement (GO:1903115)2.86268364
115regulation of cAMP-dependent protein kinase activity (GO:2000479)2.85695395
116negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.84261957
117sequestering of metal ion (GO:0051238)2.84213532
118succinate metabolic process (GO:0006105)2.80869542
119negative regulation of peptide secretion (GO:0002792)2.80776335
120sarcoplasmic reticulum calcium ion transport (GO:0070296)2.80378218
121negative regulation of glycoprotein biosynthetic process (GO:0010561)2.80270032
122regulation of peptide transport (GO:0090087)2.79896150
123intra-Golgi vesicle-mediated transport (GO:0006891)2.76232109
1242-oxoglutarate metabolic process (GO:0006103)2.75769085
125regulation of nuclease activity (GO:0032069)2.75425802
126regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.75417125
127synaptic vesicle docking involved in exocytosis (GO:0016081)2.73524312
128positive regulation of lipid storage (GO:0010884)2.73273083
129protein localization to Golgi apparatus (GO:0034067)2.72534202
130toxin metabolic process (GO:0009404)2.72345255
131negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.70282159
132negative regulation of calcium ion transmembrane transport (GO:1903170)2.70282159
133transcytosis (GO:0045056)2.69587341
134response to dietary excess (GO:0002021)2.67437523
135negative regulation of potassium ion transmembrane transport (GO:1901380)2.66655231
136response to epinephrine (GO:0071871)2.66147264
137fatty acid beta-oxidation (GO:0006635)2.63992719
138cardiac muscle hypertrophy (GO:0003300)2.63224575
139regulation of calcium ion transmembrane transporter activity (GO:1901019)2.62828763
140regulation of calcium ion transmembrane transport (GO:1903169)2.62828763
141endoplasmic reticulum unfolded protein response (GO:0030968)2.62690545
142cellular zinc ion homeostasis (GO:0006882)2.62507744
143regulation of glucocorticoid secretion (GO:2000849)2.61276638
144neurotransmitter secretion (GO:0007269)2.59971572
145tricarboxylic acid metabolic process (GO:0072350)2.59852978
146signal release (GO:0023061)2.59575901
147ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)2.59150964
148cellular response to unfolded protein (GO:0034620)2.58278722
149hormone secretion (GO:0046879)2.57731039
150activation of adenylate cyclase activity (GO:0007190)2.57634069
151regulation of neuronal synaptic plasticity (GO:0048168)2.57570317
152cellular response to topologically incorrect protein (GO:0035967)2.57396622
153regulation of vesicle fusion (GO:0031338)2.57352417
154neuromuscular synaptic transmission (GO:0007274)2.57094372
155inner ear receptor cell development (GO:0060119)2.56923823
156striated muscle hypertrophy (GO:0014897)2.56601090
157positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.56590295
158alanine transport (GO:0032328)2.56187144
159negative regulation of appetite (GO:0032099)2.56159688
160negative regulation of response to food (GO:0032096)2.56159688
161cellular response to epinephrine stimulus (GO:0071872)2.55594877
162ethanol oxidation (GO:0006069)2.54455347
163regulation of autophagic vacuole assembly (GO:2000785)2.54318836
164innervation (GO:0060384)2.53885525
165carnitine transmembrane transport (GO:1902603)2.53826819
166lipid storage (GO:0019915)2.53720271
167regulation of insulin secretion involved in cellular response to glucose stimulus (GO:0061178)2.53141343
168adult heart development (GO:0007512)2.53049260
169peptide transport (GO:0015833)2.52954562
170hexose biosynthetic process (GO:0019319)2.52739375
171regulation of amyloid precursor protein catabolic process (GO:1902991)2.52638326
172calcium-mediated signaling using intracellular calcium source (GO:0035584)2.51450791
173regulation of glucokinase activity (GO:0033131)2.51437779
174regulation of hexokinase activity (GO:1903299)2.51437779
175fructose metabolic process (GO:0006000)2.51229142
176ER-nucleus signaling pathway (GO:0006984)2.51083250
177response to glucagon (GO:0033762)2.51074402
178white fat cell differentiation (GO:0050872)2.50090696
179regulation of exocytosis (GO:0017157)2.49382775
180regulation of lipoprotein metabolic process (GO:0050746)2.49159858
181negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.49021461
182positive regulation of membrane potential (GO:0045838)2.48835628
183lactate metabolic process (GO:0006089)2.48716384
184skeletal muscle tissue development (GO:0007519)2.48308854
185positive regulation of hormone secretion (GO:0046887)2.47703930
186fatty acid catabolic process (GO:0009062)2.46703625
187response to hexose (GO:0009746)2.46166773
188amino-acid betaine transport (GO:0015838)2.45086451
189carnitine transport (GO:0015879)2.45086451
190* glycogen metabolic process (GO:0005977)2.44929933
191response to glucose (GO:0009749)2.44905496
192response to catecholamine (GO:0071869)2.41901516
193response to monoamine (GO:0071867)2.41901516
194positive regulation of fatty acid oxidation (GO:0046321)2.39064120

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.87578387
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.52078046
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.24767110
4REST_21632747_ChIP-Seq_MESCs_Mouse2.89233489
5GBX2_23144817_ChIP-Seq_PC3_Human2.80041064
6SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.57684438
7SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.44638360
8* RARB_27405468_Chip-Seq_BRAIN_Mouse2.44226769
9REST_18959480_ChIP-ChIP_MESCs_Mouse2.43823155
10SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.33052483
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.32881673
12SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.22896682
13MTF2_20144788_ChIP-Seq_MESCs_Mouse2.20214370
14JARID2_20064375_ChIP-Seq_MESCs_Mouse2.20017626
15EZH2_27294783_Chip-Seq_ESCs_Mouse2.12121751
16CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.10596485
17EZH2_27304074_Chip-Seq_ESCs_Mouse2.07488128
18SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.04964095
19SUZ12_27294783_Chip-Seq_ESCs_Mouse2.02330475
20CBX2_27304074_Chip-Seq_ESCs_Mouse1.98975893
21DROSHA_22980978_ChIP-Seq_HELA_Human1.93433210
22EZH2_18974828_ChIP-Seq_MESCs_Mouse1.92544678
23RNF2_18974828_ChIP-Seq_MESCs_Mouse1.92544678
24DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.88302160
25PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.85294805
26* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.82427414
27NR3C1_23031785_ChIP-Seq_PC12_Mouse1.81538181
28SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.81107714
29ZNF274_21170338_ChIP-Seq_K562_Hela1.80571992
30EED_16625203_ChIP-ChIP_MESCs_Mouse1.76896743
31VDR_22108803_ChIP-Seq_LS180_Human1.76844831
32TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.69968651
33RNF2_27304074_Chip-Seq_ESCs_Mouse1.67701430
34ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.64319125
35FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.62977989
36GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.60028513
37CDX2_19796622_ChIP-Seq_MESCs_Mouse1.54530786
38PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.53816184
39NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.53663000
40CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.53058477
41ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.49945374
42CTBP2_25329375_ChIP-Seq_LNCAP_Human1.48178728
43IGF1R_20145208_ChIP-Seq_DFB_Human1.44311254
44THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.44194437
45BMI1_23680149_ChIP-Seq_NPCS_Mouse1.41288535
46PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.40528215
47OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.40447261
48EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.38619160
49* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.38576828
50RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.37798717
51TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.37456162
52EP300_21415370_ChIP-Seq_HL-1_Mouse1.36723534
53TP53_20018659_ChIP-ChIP_R1E_Mouse1.33760286
54TRIM28_21343339_ChIP-Seq_HEK293_Human1.32002660
55ERG_21242973_ChIP-ChIP_JURKAT_Human1.31725107
56PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.29494620
57SMAD4_21799915_ChIP-Seq_A2780_Human1.29387100
58RXR_22158963_ChIP-Seq_LIVER_Mouse1.26385064
59TBX20_22328084_ChIP-Seq_HEART_Mouse1.24455129
60TBX20_22080862_ChIP-Seq_HEART_Mouse1.24455129
61CTBP1_25329375_ChIP-Seq_LNCAP_Human1.22039421
62SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.21718430
63RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.18566224
64SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.17922521
65SOX2_21211035_ChIP-Seq_LN229_Gbm1.14459246
66PIAS1_25552417_ChIP-Seq_VCAP_Human1.13937668
67* CTCF_27219007_Chip-Seq_Bcells_Human1.13671787
68REST_19997604_ChIP-ChIP_NEURONS_Mouse1.12983771
69STAT3_23295773_ChIP-Seq_U87_Human1.12060799
70YAP1_20516196_ChIP-Seq_MESCs_Mouse1.10365652
71TOP2B_26459242_ChIP-Seq_MCF-7_Human1.08850624
72AR_19668381_ChIP-Seq_PC3_Human1.08231783
73GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.08161585
74PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.07312271
75HTT_18923047_ChIP-ChIP_STHdh_Human1.06392683
76TET1_21490601_ChIP-Seq_MESCs_Mouse1.06189103
77RNF2_27304074_Chip-Seq_NSC_Mouse1.05864274
78LXR_22158963_ChIP-Seq_LIVER_Mouse1.05169508
79CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.04743875
80EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.04722556
81SMAD3_21741376_ChIP-Seq_ESCs_Human1.04197371
82* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.02962007
83EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.02354648
84PPARA_22158963_ChIP-Seq_LIVER_Mouse1.01086426
85GATA1_22025678_ChIP-Seq_K562_Human1.00535802
86RING1B_27294783_Chip-Seq_ESCs_Mouse1.00151199
87DNAJC2_21179169_ChIP-ChIP_NT2_Human0.98676140
88OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.98423336
89ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.98080180
90NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.97182827
91BCAT_22108803_ChIP-Seq_LS180_Human0.96309766
92* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.95900058
93RBPJ_22232070_ChIP-Seq_NCS_Mouse0.95429538
94BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.95140167
95MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.94762201
96ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.93694731
97GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93514192
98RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.92661433
99SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.92635656
100ZNF217_24962896_ChIP-Seq_MCF-7_Human0.92136216
101KDM2B_26808549_Chip-Seq_K562_Human0.91629397
102ZFP281_18757296_ChIP-ChIP_E14_Mouse0.91132402
103DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.90706494
104IKZF1_21737484_ChIP-ChIP_HCT116_Human0.90304220
105TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.89584873
106MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.88973567
107SMAD4_21741376_ChIP-Seq_HESCs_Human0.88788376
108EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.88662986
109CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.88351986
110AR_25329375_ChIP-Seq_VCAP_Human0.87310411
111MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.87276714
112FLI1_21867929_ChIP-Seq_TH2_Mouse0.86246844
113P300_19829295_ChIP-Seq_ESCs_Human0.85852608
114RING1B_27294783_Chip-Seq_NPCs_Mouse0.84369663
115TDRD3_21172665_ChIP-Seq_MCF-7_Human0.83585063
116TP53_22573176_ChIP-Seq_HFKS_Human0.82747394
117TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.82615348
118P53_22127205_ChIP-Seq_FIBROBLAST_Human0.82090888
119TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.81515151
120AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.81454103
121BP1_19119308_ChIP-ChIP_Hs578T_Human0.81431846
122MYC_27129775_Chip-Seq_CORNEA_Mouse0.81165643
123LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.81122032
124* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.80906705
125SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.80664683
126* RAD21_21589869_ChIP-Seq_MESCs_Mouse0.80647505
127SMAD3_21741376_ChIP-Seq_EPCs_Human0.80552618
128TCF4_23295773_ChIP-Seq_U87_Human0.80471195
129SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.80304935
130STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.80228720
131NR3C1_21868756_ChIP-Seq_MCF10A_Human0.78566160
132LXR_22292898_ChIP-Seq_THP-1_Human0.78310732
133SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.77959232
134ZFP57_27257070_Chip-Seq_ESCs_Mouse0.77865872
135MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.77787808
136TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.77324075
137RUNX2_22187159_ChIP-Seq_PCA_Human0.77233142
138ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.76721437
139CBP_21632823_ChIP-Seq_H3396_Human0.76457252
140CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.75490780
141NFIB_24661679_ChIP-Seq_LUNG_Mouse0.75140210

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004043_abnormal_pH_regulation4.99586174
2MP0003283_abnormal_digestive_organ4.71566032
3MP0003646_muscle_fatigue4.40239102
4MP0004130_abnormal_muscle_cell4.25158952
5MP0005670_abnormal_white_adipose3.90784645
6MP0000751_myopathy3.85931022
7MP0009780_abnormal_chondrocyte_physiolo3.73620268
8MP0002909_abnormal_adrenal_gland3.60488752
9MP0000749_muscle_degeneration3.23755267
10MP0004859_abnormal_synaptic_plasticity3.17308049
11MP0003195_calcinosis3.02655493
12MP0002877_abnormal_melanocyte_morpholog2.98938378
13MP0002693_abnormal_pancreas_physiology2.98353613
14MP0000013_abnormal_adipose_tissue2.90678931
15MP0010386_abnormal_urinary_bladder2.87723269
16MP0004270_analgesia2.76680111
17MP0004036_abnormal_muscle_relaxation2.70772067
18MP0001944_abnormal_pancreas_morphology2.70421477
19MP0005666_abnormal_adipose_tissue2.70228858
20MP0002971_abnormal_brown_adipose2.58072977
21MP0002837_dystrophic_cardiac_calcinosis2.49479678
22MP0002106_abnormal_muscle_physiology2.32893790
23MP0005646_abnormal_pituitary_gland2.27560957
24MP0004087_abnormal_muscle_fiber2.22478234
25MP0000678_abnormal_parathyroid_gland2.22214924
26MP0000759_abnormal_skeletal_muscle2.20006797
27MP0005379_endocrine/exocrine_gland_phen2.19885501
28* MP0003635_abnormal_synaptic_transmissio2.11483724
29MP0005369_muscle_phenotype2.06806932
30MP0005620_abnormal_muscle_contractility2.01969955
31MP0000747_muscle_weakness1.98569322
32MP0004084_abnormal_cardiac_muscle1.98151942
33MP0004185_abnormal_adipocyte_glucose1.98066668
34MP0002078_abnormal_glucose_homeostasis1.85783399
35MP0001765_abnormal_ion_homeostasis1.83540472
36MP0008961_abnormal_basal_metabolism1.79906291
37MP0006072_abnormal_retinal_apoptosis1.78160053
38MP0002638_abnormal_pupillary_reflex1.77485606
39MP0002734_abnormal_mechanical_nocicepti1.76133950
40MP0003183_abnormal_peptide_metabolism1.75905534
41MP0004215_abnormal_myocardial_fiber1.75268158
42MP0002332_abnormal_exercise_endurance1.74606910
43MP0002063_abnormal_learning/memory/cond1.70488123
44MP0005220_abnormal_exocrine_pancreas1.68187339
45MP0003011_delayed_dark_adaptation1.64238553
46MP0001984_abnormal_olfaction1.62893198
47MP0002972_abnormal_cardiac_muscle1.62605021
48MP0000750_abnormal_muscle_regeneration1.62452112
49MP0002733_abnormal_thermal_nociception1.60276659
50MP0005645_abnormal_hypothalamus_physiol1.59724414
51MP0003122_maternal_imprinting1.57856006
52MP0002269_muscular_atrophy1.55441517
53MP0005330_cardiomyopathy1.55160943
54MP0003880_abnormal_central_pattern1.54782574
55MP0002572_abnormal_emotion/affect_behav1.49800245
56MP0006138_congestive_heart_failure1.49788778
57MP0002234_abnormal_pharynx_morphology1.48932036
58MP0010329_abnormal_lipoprotein_level1.48331922
59MP0009745_abnormal_behavioral_response1.47071855
60MP0005535_abnormal_body_temperature1.46708604
61MP0001756_abnormal_urination1.44553492
62MP0002272_abnormal_nervous_system1.44520739
63MP0002064_seizures1.44183739
64MP0002108_abnormal_muscle_morphology1.41804204
65MP0000003_abnormal_adipose_tissue1.40274520
66MP0001970_abnormal_pain_threshold1.36639364
67MP0002928_abnormal_bile_duct1.35210104
68MP0003123_paternal_imprinting1.34429079
69MP0002735_abnormal_chemical_nociception1.32664743
70MP0001986_abnormal_taste_sensitivity1.32640912
71MP0001544_abnormal_cardiovascular_syste1.31344718
72MP0005385_cardiovascular_system_phenoty1.31344718
73MP0003329_amyloid_beta_deposits1.29214231
74MP0000462_abnormal_digestive_system1.29046114
75MP0001968_abnormal_touch/_nociception1.28447906
76MP0001502_abnormal_circadian_rhythm1.27736216
77MP0004145_abnormal_muscle_electrophysio1.27325706
78MP0002876_abnormal_thyroid_physiology1.25174254
79MP0003953_abnormal_hormone_level1.23113334
80MP0009643_abnormal_urine_homeostasis1.22767238
81MP0004885_abnormal_endolymph1.22110952
82MP0000631_abnormal_neuroendocrine_gland1.22015496
83MP0009115_abnormal_fat_cell1.21570901
84MP0003879_abnormal_hair_cell1.21155397
85MP0005334_abnormal_fat_pad1.20919256
86MP0002822_catalepsy1.18863206
87MP0003137_abnormal_impulse_conducting1.17612988
88MP0004858_abnormal_nervous_system1.16774483
89MP0001501_abnormal_sleep_pattern1.13681034
90MP0000955_abnormal_spinal_cord1.12870503
91MP0002118_abnormal_lipid_homeostasis1.11096098
92MP0006276_abnormal_autonomic_nervous1.10916952
93MP0002557_abnormal_social/conspecific_i1.10536182
94MP0004484_altered_response_of1.09973113
95MP0005266_abnormal_metabolism1.09638976
96MP0005636_abnormal_mineral_homeostasis1.07591080
97MP0008775_abnormal_heart_ventricle1.07376736
98MP0005452_abnormal_adipose_tissue1.06635353
99MP0003172_abnormal_lysosome_physiology1.05403480
100MP0001486_abnormal_startle_reflex1.05361389
101MP0002067_abnormal_sensory_capabilities1.04496604
102MP0002896_abnormal_bone_mineralization1.01372037
103MP0003119_abnormal_digestive_system0.98964247
104MP0004811_abnormal_neuron_physiology0.97766092
105MP0000230_abnormal_systemic_arterial0.97099570
106MP0005451_abnormal_body_composition0.96908299
107MP0005332_abnormal_amino_acid0.96404693
108MP0002069_abnormal_eating/drinking_beha0.96338264
109MP0002736_abnormal_nociception_after0.95839652
110MP0001661_extended_life_span0.93451135
111MP0002184_abnormal_innervation0.93252157
112MP0002970_abnormal_white_adipose0.92303519
113MP0004142_abnormal_muscle_tone0.90481670
114MP0010630_abnormal_cardiac_muscle0.90116562
115MP0005423_abnormal_somatic_nervous0.88449523
116MP0000733_abnormal_muscle_development0.88406564
117MP0003959_abnormal_lean_body0.87146608
118MP0003690_abnormal_glial_cell0.86267857
119MP0009046_muscle_twitch0.86157895
120MP0003787_abnormal_imprinting0.85630158
121MP0005187_abnormal_penis_morphology0.85626475
122MP0002066_abnormal_motor_capabilities/c0.84647731
123MP0000538_abnormal_urinary_bladder0.84399366
124MP0002127_abnormal_cardiovascular_syste0.83885675
125MP0002882_abnormal_neuron_morphology0.83644806
126MP0004233_abnormal_muscle_weight0.82887666
127MP0002653_abnormal_ependyma_morphology0.82300410
128MP0008569_lethality_at_weaning0.81337450
129MP0004510_myositis0.80981463
130MP0002229_neurodegeneration0.78013682
131MP0001270_distended_abdomen0.77789875
132MP0001440_abnormal_grooming_behavior0.77392322
133MP0004264_abnormal_extraembryonic_tissu0.76953011
134MP0004924_abnormal_behavior0.76099350
135MP0005386_behavior/neurological_phenoty0.76099350
136MP0005448_abnormal_energy_balance0.74265717
137MP0005058_abnormal_lysosome_morphology0.73485003
138MP0003633_abnormal_nervous_system0.73232672
139MP0003948_abnormal_gas_homeostasis0.73093616
140MP0006036_abnormal_mitochondrial_physio0.72663651
141MP0005253_abnormal_eye_physiology0.72350172
142MP0005167_abnormal_blood-brain_barrier0.72236758
143MP0001299_abnormal_eye_distance/0.71946050
144MP0003121_genomic_imprinting0.69891715
145MP0004085_abnormal_heartbeat0.69331465
146MP0002163_abnormal_gland_morphology0.69249421
147MP0001664_abnormal_digestion0.68990510
148MP0003634_abnormal_glial_cell0.68180726
149MP0001485_abnormal_pinna_reflex0.66308172
150MP0005375_adipose_tissue_phenotype0.65971495
151MP0003828_pulmonary_edema0.65269014
152MP0002139_abnormal_hepatobiliary_system0.64513185

Predicted human phenotypes

RankGene SetZ-score
1Muscle fiber inclusion bodies (HP:0100299)8.22553719
2Nemaline bodies (HP:0003798)8.02030473
3Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)7.88090753
4Exercise-induced myalgia (HP:0003738)6.69671835
5Type 1 muscle fiber predominance (HP:0003803)6.42047643
6Hyperinsulinemic hypoglycemia (HP:0000825)6.15649033
7Hypoglycemic seizures (HP:0002173)5.56097153
8Exercise-induced muscle cramps (HP:0003710)5.51486905
9Muscle hypertrophy of the lower extremities (HP:0008968)5.28984833
10Elevated circulating parathyroid hormone (PTH) level (HP:0003165)5.23394646
11Symptomatic seizures (HP:0011145)5.08205399
12Hypokalemic alkalosis (HP:0001949)4.93115705
13Hyperactive renin-angiotensin system (HP:0000841)4.88883838
14Hypoglycemic coma (HP:0001325)4.78535452
15Calf muscle hypertrophy (HP:0008981)4.78289098
16Increased circulating renin level (HP:0000848)4.53665509
17Rhabdomyolysis (HP:0003201)4.46528764
18EMG: myopathic abnormalities (HP:0003458)4.35465408
19Muscle fiber splitting (HP:0003555)4.29594226
20Hypokalemia (HP:0002900)4.25987854
21Hyporeflexia of lower limbs (HP:0002600)4.25732073
22Decreased circulating renin level (HP:0003351)4.22185439
23Ketoacidosis (HP:0001993)4.21329775
24Metabolic alkalosis (HP:0200114)4.20985772
25Distal arthrogryposis (HP:0005684)4.19988350
26Difficulty running (HP:0009046)4.13881979
27Myopathic facies (HP:0002058)4.11683094
28Abnormality of chloride homeostasis (HP:0011422)4.08866937
29Rimmed vacuoles (HP:0003805)4.00147278
30Abnormality of skeletal muscle fiber size (HP:0012084)3.98424610
31Abnormality of renin-angiotensin system (HP:0000847)3.94293275
32Abnormality of the calf musculature (HP:0001430)3.91568209
33Visual hallucinations (HP:0002367)3.79691283
34Insulin-resistant diabetes mellitus (HP:0000831)3.74555806
35Round ear (HP:0100830)3.70989388
36Frequent falls (HP:0002359)3.67667087
37Hyperaldosteronism (HP:0000859)3.66718731
38Increased variability in muscle fiber diameter (HP:0003557)3.63502348
39Hypomagnesemia (HP:0002917)3.56729089
40Abnormality of calcium-phosphate metabolism (HP:0100530)3.55114217
41Myotonia (HP:0002486)3.52467220
42Neck muscle weakness (HP:0000467)3.50536221
43Gout (HP:0001997)3.49569680
44Polyuria (HP:0000103)3.49198232
45Abnormality of magnesium homeostasis (HP:0004921)3.47124444
46Abnormality of potassium homeostasis (HP:0011042)3.43931434
47Abnormal pancreas size (HP:0012094)3.42394743
48Sudden death (HP:0001699)3.34220731
49Subaortic stenosis (HP:0001682)3.32426465
50Abnormality of the left ventricular outflow tract (HP:0011103)3.32426465
51Late onset (HP:0003584)3.29177975
52Centrally nucleated skeletal muscle fibers (HP:0003687)3.29000844
53Asymmetric septal hypertrophy (HP:0001670)3.25152848
54Bundle branch block (HP:0011710)3.25127030
55Renal salt wasting (HP:0000127)3.24579132
56Muscle stiffness (HP:0003552)3.23195924
57Abnormal urine output (HP:0012590)3.19895264
58Hyperglycemia (HP:0003074)3.19198892
59Abnormality of endocrine pancreas physiology (HP:0012093)3.15821948
60Abnormality of the pancreatic islet cells (HP:0006476)3.15821948
61Ulnar deviation of the wrist (HP:0003049)3.13859442
62Large for gestational age (HP:0001520)3.13254405
63Polydipsia (HP:0001959)3.09525046
64Abnormal drinking behavior (HP:0030082)3.09525046
65Pancreatic islet-cell hyperplasia (HP:0004510)2.95388965
66Pheochromocytoma (HP:0002666)2.89269833
67Adrenal overactivity (HP:0002717)2.83175101
68Generalized aminoaciduria (HP:0002909)2.82992862
69EMG: neuropathic changes (HP:0003445)2.82061841
70Alkalosis (HP:0001948)2.80604325
71Calcaneovalgus deformity (HP:0001848)2.76516614
72Abnormality of renal excretion (HP:0011036)2.73834615
73Fetal akinesia sequence (HP:0001989)2.71421274
74Agitation (HP:0000713)2.70335531
75Hyperkalemia (HP:0002153)2.69157498
76Tetany (HP:0001281)2.62611092
77Mucopolysacchariduria (HP:0008155)2.62016188
78Urinary glycosaminoglycan excretion (HP:0003541)2.62016188
79Increased connective tissue (HP:0009025)2.60552437
80Generalized muscle weakness (HP:0003324)2.55062344
81Dysostosis multiplex (HP:0000943)2.54187306
82Absent phalangeal crease (HP:0006109)2.54018148
83EEG with generalized epileptiform discharges (HP:0011198)2.50864928
84Epileptiform EEG discharges (HP:0011182)2.47125470
85Neuroendocrine neoplasm (HP:0100634)2.46847176
86Ketosis (HP:0001946)2.46383355
87Hyperparathyroidism (HP:0000843)2.45823680
88Abnormality of mucopolysaccharide metabolism (HP:0011020)2.42988294
89Abnormality of polysaccharide metabolism (HP:0011012)2.42988294
90Abnormality of glycosaminoglycan metabolism (HP:0004371)2.42988294
91Hypsarrhythmia (HP:0002521)2.42765439
92Deformed tarsal bones (HP:0008119)2.42756248
93Distal lower limb muscle weakness (HP:0009053)2.40419417
94Dilated cardiomyopathy (HP:0001644)2.40182928
95Osteomalacia (HP:0002749)2.39006344
96Focal motor seizures (HP:0011153)2.38938182
97Heart block (HP:0012722)2.35171399
98Hypotension (HP:0002615)2.35163285
99Gowers sign (HP:0003391)2.30730907
100Myokymia (HP:0002411)2.28828414
101Increased muscle lipid content (HP:0009058)2.26770144
102Scapular winging (HP:0003691)2.25813171
103Chronic bronchitis (HP:0004469)2.23806569
104Areflexia of lower limbs (HP:0002522)2.21680556
105Lipoatrophy (HP:0100578)2.21486978
106Ventricular tachycardia (HP:0004756)2.18531797
107Mildly elevated creatine phosphokinase (HP:0008180)2.17724875
108Insulin resistance (HP:0000855)2.16201140
109Anxiety (HP:0000739)2.16184706
110Abnormal atrioventricular conduction (HP:0005150)2.13047931
111Papilledema (HP:0001085)2.11419799
112Hyperphosphaturia (HP:0003109)2.11396458
113Bulbar palsy (HP:0001283)2.10713829
114Abnormality of sodium homeostasis (HP:0010931)2.09973641
115Myoglobinuria (HP:0002913)2.08054077
116Malignant hyperthermia (HP:0002047)2.05992420
117Prolonged QT interval (HP:0001657)2.05160638
118Limb hypertonia (HP:0002509)2.02638089
119Polyphagia (HP:0002591)2.01288001
120Abnormal finger flexion creases (HP:0006143)1.99787660
121Hypercortisolism (HP:0001578)1.99631472
122Weak cry (HP:0001612)1.98623985
123Hyponatremia (HP:0002902)1.98554142
124Depression (HP:0000716)1.98077542
125Atonic seizures (HP:0010819)1.97626841
126Resting tremor (HP:0002322)1.97392811
127Abnormality of purine metabolism (HP:0004352)1.96114577
128Spinal rigidity (HP:0003306)1.95862867
129Exercise intolerance (HP:0003546)1.95326160
130Unilateral renal agenesis (HP:0000122)1.93808883
131Abnormality of fatty-acid metabolism (HP:0004359)1.91890644
132Abnormality of the foot musculature (HP:0001436)1.90331656
133Dysautonomia (HP:0002459)1.90229481
134Increased purine levels (HP:0004368)1.89286891
135Hyperuricemia (HP:0002149)1.89286891
136Epileptic encephalopathy (HP:0200134)1.88544770
137Hip contracture (HP:0003273)1.86446920
138Waddling gait (HP:0002515)1.85911418
139Ventricular arrhythmia (HP:0004308)1.85668634
140Absence seizures (HP:0002121)1.84572631
141Abnormal EKG (HP:0003115)1.84376250
142Menstrual irregularities (HP:0000858)1.83766385
143Acanthosis nigricans (HP:0000956)1.83323278
144Hypothermia (HP:0002045)1.82954939
145Generalized tonic-clonic seizures (HP:0002069)1.82767813
146Slender build (HP:0001533)1.82327006
147Abnormal eating behavior (HP:0100738)1.81725650
148Fatigable weakness (HP:0003473)1.79940496
149Abnormality of the neuromuscular junction (HP:0003398)1.79940496
150Increased intramyocellular lipid droplets (HP:0012240)1.78372050
151Foot dorsiflexor weakness (HP:0009027)1.77819857
152Acute necrotizing encephalopathy (HP:0006965)1.77367104
153Atrial fibrillation (HP:0005110)1.77204303
154Syncope (HP:0001279)1.77138180
155Hypophosphatemia (HP:0002148)1.76829327
156Hepatic necrosis (HP:0002605)1.76633968
157Double outlet right ventricle (HP:0001719)1.76320861
158Congenital malformation of the right heart (HP:0011723)1.76320861
159Ventricular fibrillation (HP:0001663)1.75328215
160Restlessness (HP:0000711)1.74202240
161Focal seizures (HP:0007359)1.73492977
162Respiratory insufficiency due to muscle weakness (HP:0002747)1.72415695
163Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.72049638
164Abnormality of the shoulder girdle musculature (HP:0001435)1.71678799
165Abnormal urine phosphate concentration (HP:0012599)1.71486446
166Supranuclear gaze palsy (HP:0000605)1.71092429
167Retinal atrophy (HP:0001105)1.70606485
168Type II lissencephaly (HP:0007260)1.70265602
169Oligomenorrhea (HP:0000876)1.68410470
170Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.68115685
171Primary atrial arrhythmia (HP:0001692)1.67814236
172Difficulty climbing stairs (HP:0003551)1.67251982
173Distal lower limb amyotrophy (HP:0008944)1.66926638
174Proximal amyotrophy (HP:0007126)1.65917427
175Hyperphosphatemia (HP:0002905)1.65579278
176Limb-girdle muscle atrophy (HP:0003797)1.65186858
177Progressive macrocephaly (HP:0004481)1.65039947
178Abnormality of aromatic amino acid family metabolism (HP:0004338)1.62940743
179Thoracolumbar scoliosis (HP:0002944)1.62883735
180Hypercalciuria (HP:0002150)1.61986480
181Glycosuria (HP:0003076)1.61572052
182Abnormality of urine glucose concentration (HP:0011016)1.61572052
183Abnormal mitochondria in muscle tissue (HP:0008316)1.60636628
184Cortical visual impairment (HP:0100704)1.60314779
185Irritability (HP:0000737)1.60164804
186Hepatoblastoma (HP:0002884)1.57414753

Predicted kinase interactions (KEA)

RankGene SetZ-score
1INSRR5.56646418
2PASK4.81925953
3TTN3.94212594
4WNK33.87007430
5PRKD33.55150046
6NTRK33.49694767
7MAPK153.44460500
8WNK43.37105129
9MAP3K22.70233269
10NTRK12.45154238
11HIPK22.31201493
12EPHA42.04333552
13MAPK121.75275810
14MARK11.74474427
15OXSR11.70607610
16MAP3K91.64327132
17UHMK11.52428664
18KSR21.52072674
19CAMKK21.46718966
20PRKAA21.44350066
21PIK3CG1.43207593
22CAMK11.42447126
23DAPK21.38476186
24MAP3K41.36008603
25MINK11.36006545
26PHKG21.32804026
27PHKG11.32804026
28MAP3K11.31911074
29PAK31.31075353
30CASK1.26469236
31SCYL21.21549637
32MUSK1.21182664
33FRK1.20444785
34BCKDK1.20049335
35GRK51.19871199
36TIE11.19473512
37PAK61.18214393
38TNIK1.17407406
39DMPK1.13397038
40FLT31.06639927
41ARAF1.04359941
42PRKCH1.01970855
43MAP3K71.01359050
44CDC42BPA1.01211457
45SGK2231.00619099
46SGK4941.00619099
47EPHB21.00534744
48TRPM70.98556592
49MAP2K60.98527780
50CAMKK10.98525238
51PDGFRA0.97209005
52ERN10.95072219
53BRAF0.93128662
54PTK20.92328435
55PRKD20.91187757
56TAOK30.91142908
57* CDK50.90190972
58MAP2K70.88688796
59PRKG10.88257656
60DAPK10.87337066
61PRKCG0.85729011
62STK110.85346230
63RIPK10.84814610
64STK160.81872952
65PKN10.80866560
66LIMK10.80781480
67NME10.78812250
68MAPK40.78533241
69NTRK20.78526530
70LATS20.77849870
71KSR10.76606920
72SGK20.76074048
73CAMK2B0.73414366
74PINK10.70949743
75WNK10.70655444
76MAPKAPK30.69757351
77TRIB30.69595028
78CAMK40.69114463
79MAPK130.68306721
80PRKCE0.68017059
81MAP2K40.67824373
82DYRK1A0.63146787
83CAMK2D0.62932258
84DYRK20.62300753
85FER0.62239278
86RET0.62085195
87AKT20.60959545
88MOS0.60469756
89ABL20.59684744
90PRPF4B0.59610015
91MAP3K110.59569537
92NLK0.58856223
93PRKAA10.56379276
94IRAK10.56362612
95MYLK0.56054512
96RIPK40.55509751
97MARK20.54878318
98PRKCI0.54333004
99SIK10.54019749
100DYRK1B0.53648651
101BMPR20.53352703
102STK380.53038920
103CAMK1G0.52643697
104CAMK2A0.52578563
105SGK10.51967275
106EPHA30.51753807
107PNCK0.51711686
108PDK20.51324218
109SGK30.50859959
110GRK10.48447129
111* RPS6KA30.48397264
112OBSCN0.48066798
113MET0.47791177
114MAP2K10.46267701
115MAP2K30.45473577
116PRKACB0.44422012
117PRKACG0.44239743
118CAMK1D0.44165840
119NEK10.44100260
120AKT30.44050397
121CDK140.43708410
122CSNK1A10.43354956
123BRSK10.43027453
124TESK10.42573816
125RPS6KA20.42192638
126MAP2K20.41280890
127ICK0.40593200
128* PRKACA0.40474201
129FGFR20.40398246
130ROCK10.39743188
131IRAK20.38786897
132EPHB10.37737132
133BCR0.37234068
134PIK3CA0.36860876
135PDPK10.33547855
136PRKD10.33411050
137PDK10.33063331
138PLK20.32648228
139PRKCZ0.32605914
140MAPK100.32066008
141LMTK20.30599565
142CSNK1G20.30589113
143ERBB30.30537765
144CDK180.30058907
145TAOK10.28802201
146ADRBK10.28776293
147CAMK2G0.28678810

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049506.36219737
2Insulin secretion_Homo sapiens_hsa049113.30136234
3Protein export_Homo sapiens_hsa030603.28734290
4Synaptic vesicle cycle_Homo sapiens_hsa047212.43972579
5Sulfur metabolism_Homo sapiens_hsa009202.39812369
6Fatty acid degradation_Homo sapiens_hsa000712.32087441
7Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.30268460
8Vibrio cholerae infection_Homo sapiens_hsa051102.23871863
9PPAR signaling pathway_Homo sapiens_hsa033202.22600853
102-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.21913099
11Type II diabetes mellitus_Homo sapiens_hsa049302.16373321
12Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.08839713
13Propanoate metabolism_Homo sapiens_hsa006402.01811040
14Amphetamine addiction_Homo sapiens_hsa050311.97022511
15Collecting duct acid secretion_Homo sapiens_hsa049661.95033937
16Carbohydrate digestion and absorption_Homo sapiens_hsa049731.93524517
17Pyruvate metabolism_Homo sapiens_hsa006201.90554318
18Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.89043050
19Cocaine addiction_Homo sapiens_hsa050301.87830277
20Fatty acid metabolism_Homo sapiens_hsa012121.87407767
21Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.86941608
22Fatty acid elongation_Homo sapiens_hsa000621.85873856
23Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.85736210
24Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.85469974
25Circadian entrainment_Homo sapiens_hsa047131.79950729
26Taste transduction_Homo sapiens_hsa047421.76341342
27Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.73245496
28GABAergic synapse_Homo sapiens_hsa047271.72967414
29beta-Alanine metabolism_Homo sapiens_hsa004101.65168891
30Olfactory transduction_Homo sapiens_hsa047401.62581537
31Dopaminergic synapse_Homo sapiens_hsa047281.61401427
32Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.54603566
33* Long-term potentiation_Homo sapiens_hsa047201.52100961
34Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.49714833
35Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.48256065
36Arginine biosynthesis_Homo sapiens_hsa002201.47158872
37Morphine addiction_Homo sapiens_hsa050321.45422838
38Type I diabetes mellitus_Homo sapiens_hsa049401.44009516
39Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.41290126
40Arginine and proline metabolism_Homo sapiens_hsa003301.37849961
41Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.37152073
42Aldosterone synthesis and secretion_Homo sapiens_hsa049251.37121349
43Cholinergic synapse_Homo sapiens_hsa047251.35703923
44Adipocytokine signaling pathway_Homo sapiens_hsa049201.28927191
45Nicotine addiction_Homo sapiens_hsa050331.28036153
46Glutamatergic synapse_Homo sapiens_hsa047241.27455658
47Glycerolipid metabolism_Homo sapiens_hsa005611.23671496
48Serotonergic synapse_Homo sapiens_hsa047261.23533987
49Butanoate metabolism_Homo sapiens_hsa006501.23210777
50Tyrosine metabolism_Homo sapiens_hsa003501.18205057
51Carbon metabolism_Homo sapiens_hsa012001.16885263
52Histidine metabolism_Homo sapiens_hsa003401.16723674
53Oxidative phosphorylation_Homo sapiens_hsa001901.16251496
54Glucagon signaling pathway_Homo sapiens_hsa049221.16230146
55Gastric acid secretion_Homo sapiens_hsa049711.15332329
56Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.13832912
57Pancreatic secretion_Homo sapiens_hsa049721.13315695
58Fatty acid biosynthesis_Homo sapiens_hsa000611.11457428
59Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.07331160
60Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.06939254
61Renin secretion_Homo sapiens_hsa049241.05979512
62Thyroid hormone synthesis_Homo sapiens_hsa049181.05290042
63Salivary secretion_Homo sapiens_hsa049701.03169934
64Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.02711603
65N-Glycan biosynthesis_Homo sapiens_hsa005101.01702988
66Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.01647187
67Alzheimers disease_Homo sapiens_hsa050100.98975859
68Peroxisome_Homo sapiens_hsa041460.97516639
69* Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.95593281
70Cardiac muscle contraction_Homo sapiens_hsa042600.95586728
71Circadian rhythm_Homo sapiens_hsa047100.95223483
72Lysosome_Homo sapiens_hsa041420.93244295
73Fat digestion and absorption_Homo sapiens_hsa049750.87825653
74cGMP-PKG signaling pathway_Homo sapiens_hsa040220.87714149
75Parkinsons disease_Homo sapiens_hsa050120.86226540
76Estrogen signaling pathway_Homo sapiens_hsa049150.85116386
77Ovarian steroidogenesis_Homo sapiens_hsa049130.81540347
78Regulation of autophagy_Homo sapiens_hsa041400.79251550
79Selenocompound metabolism_Homo sapiens_hsa004500.78342603
80Long-term depression_Homo sapiens_hsa047300.77430122
81cAMP signaling pathway_Homo sapiens_hsa040240.76188772
82Gap junction_Homo sapiens_hsa045400.73681462
83Calcium signaling pathway_Homo sapiens_hsa040200.73440597
84Oxytocin signaling pathway_Homo sapiens_hsa049210.73136425
85Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.70448945
86SNARE interactions in vesicular transport_Homo sapiens_hsa041300.69595130
87Insulin resistance_Homo sapiens_hsa049310.67603666
88GnRH signaling pathway_Homo sapiens_hsa049120.67372732
89Vascular smooth muscle contraction_Homo sapiens_hsa042700.67049573
90Galactose metabolism_Homo sapiens_hsa000520.66959549
91Sulfur relay system_Homo sapiens_hsa041220.66827050
92Insulin signaling pathway_Homo sapiens_hsa049100.66268198
93Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.64260049
94Other glycan degradation_Homo sapiens_hsa005110.62840636
95Alcoholism_Homo sapiens_hsa050340.62565264
96Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.62448509
97Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.62123604
98Melanogenesis_Homo sapiens_hsa049160.62108027
99Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.61907536
100Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.61499533
101Folate biosynthesis_Homo sapiens_hsa007900.60985812
102Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.60022829
103Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.59513759
104Prion diseases_Homo sapiens_hsa050200.57493679
105Retinol metabolism_Homo sapiens_hsa008300.56712097
106Phototransduction_Homo sapiens_hsa047440.56608005
107Glycosaminoglycan degradation_Homo sapiens_hsa005310.56009646
108Phosphatidylinositol signaling system_Homo sapiens_hsa040700.53577246
109Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.53530508
110Prolactin signaling pathway_Homo sapiens_hsa049170.52789247
111Glioma_Homo sapiens_hsa052140.50724858
112Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.50607596
113Huntingtons disease_Homo sapiens_hsa050160.49433772
114Tryptophan metabolism_Homo sapiens_hsa003800.47183114
115Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.44858672
116Longevity regulating pathway - mammal_Homo sapiens_hsa042110.44102886
117Glycerophospholipid metabolism_Homo sapiens_hsa005640.43944462
118Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.42480608
119Bile secretion_Homo sapiens_hsa049760.41585463
120Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.41517871
121mTOR signaling pathway_Homo sapiens_hsa041500.39642864
122Primary bile acid biosynthesis_Homo sapiens_hsa001200.39084158
123Nitrogen metabolism_Homo sapiens_hsa009100.38701891
124Pentose phosphate pathway_Homo sapiens_hsa000300.38321223
125Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.38268374
126alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.38185191
127Tight junction_Homo sapiens_hsa045300.37454854
128Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.37205561
129Linoleic acid metabolism_Homo sapiens_hsa005910.37170389
130Dorso-ventral axis formation_Homo sapiens_hsa043200.33634020
131Starch and sucrose metabolism_Homo sapiens_hsa005000.32094323
132Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.31716105
133Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.31650728
134ErbB signaling pathway_Homo sapiens_hsa040120.30621087
135AMPK signaling pathway_Homo sapiens_hsa041520.30585716
136Fructose and mannose metabolism_Homo sapiens_hsa000510.30029401
137Phenylalanine metabolism_Homo sapiens_hsa003600.27877929
138Sphingolipid metabolism_Homo sapiens_hsa006000.27760434
139Dilated cardiomyopathy_Homo sapiens_hsa054140.27607566
140Thyroid hormone signaling pathway_Homo sapiens_hsa049190.27503023
141Neurotrophin signaling pathway_Homo sapiens_hsa047220.25461310
142Mineral absorption_Homo sapiens_hsa049780.25261444
143ABC transporters_Homo sapiens_hsa020100.24885172
144Endometrial cancer_Homo sapiens_hsa052130.23721708

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