PPP1R1C

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Protein phosphatase-1 (PP1) is a major serine/threonine phosphatase that regulates a variety of cellular functions. PP1 consists of a catalytic subunit (see PPP1CA; MIM 176875) and regulatory subunits that determine the subcellular localization of PP1 or regulate its function. PPP1R1C belongs to a group of PP1 inhibitory subunits that are themselves regulated by phosphorylation (Wang et al., 2008 [PubMed 18310074]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neurofilament cytoskeleton organization (GO:0060052)7.39599653
2peripheral nervous system neuron development (GO:0048935)7.27041719
3detection of temperature stimulus (GO:0016048)7.23751258
4negative regulation of dendrite morphogenesis (GO:0050774)7.07881316
5detection of temperature stimulus involved in sensory perception of pain (GO:0050965)7.04724960
6detection of temperature stimulus involved in sensory perception (GO:0050961)7.04724960
7negative regulation of calcium ion transport into cytosol (GO:0010523)6.25583674
8neuronal action potential (GO:0019228)6.00467833
9cell migration in hindbrain (GO:0021535)5.73688000
10tachykinin receptor signaling pathway (GO:0007217)5.52933324
11behavioral response to pain (GO:0048266)5.03358860
12neuronal action potential propagation (GO:0019227)4.89320866
13negative regulation of dendrite development (GO:2000171)4.79788219
14negative regulation of homotypic cell-cell adhesion (GO:0034111)4.76973255
15membrane depolarization during action potential (GO:0086010)4.72488328
16regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)4.60064606
17response to pain (GO:0048265)4.59249952
18cullin deneddylation (GO:0010388)4.42534987
19retinal ganglion cell axon guidance (GO:0031290)4.28633742
20urinary tract smooth muscle contraction (GO:0014848)4.18874922
21protein deneddylation (GO:0000338)4.13792758
22positive regulation of synaptic transmission, GABAergic (GO:0032230)4.13767598
23regulation of platelet aggregation (GO:0090330)4.13152241
24adenosine metabolic process (GO:0046085)4.11810084
25detection of mechanical stimulus involved in sensory perception (GO:0050974)3.98568770
26calcium-mediated signaling using intracellular calcium source (GO:0035584)3.94641972
27establishment of mitochondrion localization (GO:0051654)3.82508413
28neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)3.78002300
29negative regulation of cation channel activity (GO:2001258)3.76403309
30proline transport (GO:0015824)3.74630636
31innervation (GO:0060384)3.74020772
32protein-cofactor linkage (GO:0018065)3.73663952
33negative regulation of heart rate (GO:0010459)3.71555311
34response to water (GO:0009415)3.67612912
35pyrimidine nucleobase catabolic process (GO:0006208)3.66052100
36behavioral response to nicotine (GO:0035095)3.64474874
37neuron fate specification (GO:0048665)3.62164388
38L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.54648844
39acrosome reaction (GO:0007340)3.54518040
40glycosphingolipid biosynthetic process (GO:0006688)3.53401757
41negative regulation of microtubule polymerization (GO:0031115)3.49412129
42negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.48482868
43axon cargo transport (GO:0008088)3.46371395
44negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.43911340
45sequestering of actin monomers (GO:0042989)3.42539449
46water-soluble vitamin biosynthetic process (GO:0042364)3.42157910
47positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.42109188
48amino acid salvage (GO:0043102)3.41350687
49L-methionine salvage (GO:0071267)3.41350687
50L-methionine biosynthetic process (GO:0071265)3.41350687
51establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.40624928
52mitochondrion transport along microtubule (GO:0047497)3.40624928
53serotonin receptor signaling pathway (GO:0007210)3.40192968
54glutamate secretion (GO:0014047)3.39424844
55action potential (GO:0001508)3.39358010
56membrane budding (GO:0006900)3.35009097
57negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.30525952
58nucleobase catabolic process (GO:0046113)3.27735607
59regulation of synaptic vesicle exocytosis (GO:2000300)3.25133273
60synaptic vesicle maturation (GO:0016188)3.25065692
61positive regulation of cardiac muscle hypertrophy (GO:0010613)3.25033213
62positive regulation of muscle hypertrophy (GO:0014742)3.25033213
63intermediate filament organization (GO:0045109)3.23284877
64aggressive behavior (GO:0002118)3.23229931
65response to pheromone (GO:0019236)3.21430795
66regulation of cell communication by electrical coupling (GO:0010649)3.20808363
67enteric nervous system development (GO:0048484)3.20437320
68dicarboxylic acid catabolic process (GO:0043649)3.18559766
69coenzyme catabolic process (GO:0009109)3.17138737
70anterograde synaptic vesicle transport (GO:0048490)3.16966423
71potassium ion export (GO:0071435)3.15356038
72regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.11978977
73protein complex biogenesis (GO:0070271)3.11199089
74DNA double-strand break processing (GO:0000729)3.09733930
75peroxisome fission (GO:0016559)3.09226715
76cell communication involved in cardiac conduction (GO:0086065)3.08924500
77regulation of cilium movement (GO:0003352)3.08042849
78protein polyglutamylation (GO:0018095)3.07288916
79cerebellar Purkinje cell differentiation (GO:0021702)3.04001519
80detection of calcium ion (GO:0005513)3.03336174
81bundle of His cell to Purkinje myocyte communication (GO:0086069)3.02659099
82synaptic vesicle exocytosis (GO:0016079)3.01939076
83regulation of dopamine secretion (GO:0014059)2.98695247
84negative regulation of complement activation (GO:0045916)2.98243140
85retinal cone cell development (GO:0046549)2.96472027
86behavioral response to ethanol (GO:0048149)2.95271315
87mitochondrial respiratory chain complex assembly (GO:0033108)2.95167088
88calcium ion-dependent exocytosis (GO:0017156)2.94731535
89plasma membrane repair (GO:0001778)2.94111200
90cranial nerve development (GO:0021545)2.93743511
91cellular ketone body metabolic process (GO:0046950)2.93643421
92platelet dense granule organization (GO:0060155)2.92227926
93inositol phosphate catabolic process (GO:0071545)2.91878262
94peptidyl-histidine modification (GO:0018202)2.91842529
95sodium ion transmembrane transport (GO:0035725)2.91708373
96vocalization behavior (GO:0071625)2.91703114
97regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.91688881
98regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.91021582
99cilium morphogenesis (GO:0060271)2.91008419
100negative regulation of phosphoprotein phosphatase activity (GO:0032515)2.90288432
101sensory perception of pain (GO:0019233)2.90038942
102intermediate filament-based process (GO:0045103)2.89655259
103regulation of homotypic cell-cell adhesion (GO:0034110)2.89035312
104gamma-aminobutyric acid transport (GO:0015812)2.88452182
105detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.87863246
106membrane repolarization (GO:0086009)2.86616657
107regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.86597540
108response to acidic pH (GO:0010447)2.86097012
109regulation of amyloid precursor protein catabolic process (GO:1902991)2.85494385
110response to ATP (GO:0033198)2.85471063
111regulation of short-term neuronal synaptic plasticity (GO:0048172)2.84381683
112intermediate filament cytoskeleton organization (GO:0045104)2.84166158
113cellular response to ATP (GO:0071318)2.82994443
114phasic smooth muscle contraction (GO:0014821)2.82296815
115regulation of hexokinase activity (GO:1903299)2.81997852
116regulation of glucokinase activity (GO:0033131)2.81997852
117positive regulation of potassium ion transmembrane transport (GO:1901381)2.81881475
118proteasome assembly (GO:0043248)2.81753326
119organelle transport along microtubule (GO:0072384)2.80517570
120protein localization to synapse (GO:0035418)2.80467722
121regulation of synaptic vesicle transport (GO:1902803)2.80319360
122DNA integration (GO:0015074)2.77941603
123protein neddylation (GO:0045116)2.77470417
124positive regulation of mitochondrial fission (GO:0090141)2.77324757
125mitochondrial respiratory chain complex I assembly (GO:0032981)2.76949270
126NADH dehydrogenase complex assembly (GO:0010257)2.76949270
127mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.76949270
128cornea development in camera-type eye (GO:0061303)2.75958254
129axoneme assembly (GO:0035082)2.75520289
130positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.74231806
131regulation of relaxation of muscle (GO:1901077)2.74107672
132inositol phosphate dephosphorylation (GO:0046855)2.74081051
133phosphorylated carbohydrate dephosphorylation (GO:0046838)2.74081051
134axon development (GO:0061564)2.72212757
135regulation of sodium ion transmembrane transporter activity (GO:2000649)2.71718158
136mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.71433994
137multicellular organismal response to stress (GO:0033555)2.71054988
138nonmotile primary cilium assembly (GO:0035058)2.69971387
139neuromuscular synaptic transmission (GO:0007274)2.68822030
140regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.67927521
141calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.67067893
142protein maturation by protein folding (GO:0022417)2.66478110
143regulation of mitochondrial fission (GO:0090140)2.65805550
144vesicle transport along microtubule (GO:0047496)2.65152983
145phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.64712276
146intraciliary transport (GO:0042073)2.64468888
147regulation of development, heterochronic (GO:0040034)2.64333870
148negative regulation of ion transmembrane transporter activity (GO:0032413)2.63504388
149cellular potassium ion transport (GO:0071804)2.63151898
150potassium ion transmembrane transport (GO:0071805)2.63151898
151positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc2.62464737
152respiratory chain complex IV assembly (GO:0008535)2.61373041
153regulation of action potential (GO:0098900)2.58039529
154ketone body metabolic process (GO:1902224)2.57730649
155fatty acid elongation (GO:0030497)2.57301505
156detection of light stimulus involved in sensory perception (GO:0050962)2.54890010
157detection of light stimulus involved in visual perception (GO:0050908)2.54890010
158mannosylation (GO:0097502)2.52551930
159somatic diversification of immune receptors via somatic mutation (GO:0002566)2.52299354
160somatic hypermutation of immunoglobulin genes (GO:0016446)2.52299354
161peptidyl-cysteine modification (GO:0018198)2.50387137
162succinate metabolic process (GO:0006105)2.49916452
163aspartate family amino acid biosynthetic process (GO:0009067)2.47738064
164positive regulation of action potential (GO:0045760)2.47695835
165neuron cell-cell adhesion (GO:0007158)2.47287054
166regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.47163623
167synaptic transmission, cholinergic (GO:0007271)2.46280496
168establishment of protein localization to Golgi (GO:0072600)2.45296409
169synapse assembly (GO:0007416)2.44808919
170methionine biosynthetic process (GO:0009086)2.42856784
171presynaptic membrane assembly (GO:0097105)2.42462091
172polyol catabolic process (GO:0046174)2.41636460
173positive regulation of digestive system process (GO:0060456)2.41591240
174protein targeting to Golgi (GO:0000042)2.41445970
175epithelial cilium movement (GO:0003351)2.40399908
176branched-chain amino acid catabolic process (GO:0009083)2.39025307
177regulation of cofactor metabolic process (GO:0051193)2.38226447
178regulation of coenzyme metabolic process (GO:0051196)2.38226447
179anterograde axon cargo transport (GO:0008089)2.37499326
180ribonucleoprotein complex disassembly (GO:0032988)2.36122085
181cytochrome complex assembly (GO:0017004)2.35512945
182methionine metabolic process (GO:0006555)2.34666488
183aspartate family amino acid catabolic process (GO:0009068)2.31782543
184kynurenine metabolic process (GO:0070189)2.30984902
185regulation of actin filament-based movement (GO:1903115)2.30393361

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human3.63347660
2EZH2_22144423_ChIP-Seq_EOC_Human3.51325022
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.97948161
4TAF15_26573619_Chip-Seq_HEK293_Human2.94996260
5E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.89082814
6BMI1_23680149_ChIP-Seq_NPCS_Mouse2.84665882
7SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.76705632
8JARID2_20075857_ChIP-Seq_MESCs_Mouse2.73180004
9JARID2_20064375_ChIP-Seq_MESCs_Mouse2.64340862
10FUS_26573619_Chip-Seq_HEK293_Human2.46094182
11EZH2_18974828_ChIP-Seq_MESCs_Mouse2.45468961
12RNF2_18974828_ChIP-Seq_MESCs_Mouse2.45468961
13SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.41019451
14KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.37496933
15SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.31990323
16REST_21632747_ChIP-Seq_MESCs_Mouse2.28721740
17HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.28171762
18MTF2_20144788_ChIP-Seq_MESCs_Mouse2.27298256
19SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.26055885
20EED_16625203_ChIP-ChIP_MESCs_Mouse2.24766242
21SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.24001242
22VDR_22108803_ChIP-Seq_LS180_Human2.20968039
23RBPJ_22232070_ChIP-Seq_NCS_Mouse2.18869575
24EZH2_27304074_Chip-Seq_ESCs_Mouse2.16840409
25SALL1_21062744_ChIP-ChIP_HESCs_Human2.16032328
26TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.04399488
27NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.03581291
28PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.99052098
29SMAD4_21799915_ChIP-Seq_A2780_Human1.96777752
30GABP_17652178_ChIP-ChIP_JURKAT_Human1.95190325
31EZH2_27294783_Chip-Seq_ESCs_Mouse1.94084139
32P300_19829295_ChIP-Seq_ESCs_Human1.90569049
33IGF1R_20145208_ChIP-Seq_DFB_Human1.87949521
34FLI1_27457419_Chip-Seq_LIVER_Mouse1.86650754
35ZFP57_27257070_Chip-Seq_ESCs_Mouse1.86533115
36RNF2_27304074_Chip-Seq_ESCs_Mouse1.85761374
37SUZ12_27294783_Chip-Seq_ESCs_Mouse1.85381986
38ER_23166858_ChIP-Seq_MCF-7_Human1.79674246
39EWS_26573619_Chip-Seq_HEK293_Human1.78615006
40ESR1_20079471_ChIP-ChIP_T-47D_Human1.78058275
41SMAD_19615063_ChIP-ChIP_OVARY_Human1.77144348
42* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.75472830
43TOP2B_26459242_ChIP-Seq_MCF-7_Human1.73191048
44REST_18959480_ChIP-ChIP_MESCs_Mouse1.71528630
45CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.64673340
46IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.60862417
47CBP_20019798_ChIP-Seq_JUKART_Human1.60862417
48PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.56135966
49CDX2_19796622_ChIP-Seq_MESCs_Mouse1.55481944
50GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.54751071
51RNF2_27304074_Chip-Seq_NSC_Mouse1.53581543
52PCGF2_27294783_Chip-Seq_ESCs_Mouse1.53457258
53WT1_19549856_ChIP-ChIP_CCG9911_Human1.52788632
54ELK1_19687146_ChIP-ChIP_HELA_Human1.51372738
55CTBP2_25329375_ChIP-Seq_LNCAP_Human1.51219421
56NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.45661822
57PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.43655841
58* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.43577181
59AR_25329375_ChIP-Seq_VCAP_Human1.40466816
60AHR_22903824_ChIP-Seq_MCF-7_Human1.40121005
61IRF1_19129219_ChIP-ChIP_H3396_Human1.39138008
62SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.38742255
63UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.36500573
64CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.36285662
65SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.34344526
66JUN_21703547_ChIP-Seq_K562_Human1.34046162
67TP53_22573176_ChIP-Seq_HFKS_Human1.33671385
68CTBP1_25329375_ChIP-Seq_LNCAP_Human1.32993273
69HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.32690651
70ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.30658557
71* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30348671
72MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.30343877
73NR3C1_21868756_ChIP-Seq_MCF10A_Human1.29840122
74MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.29502493
75EST1_17652178_ChIP-ChIP_JURKAT_Human1.28719748
76* STAT3_23295773_ChIP-Seq_U87_Human1.27819108
77SOX2_19829295_ChIP-Seq_ESCs_Human1.25585000
78NANOG_19829295_ChIP-Seq_ESCs_Human1.25585000
79VDR_23849224_ChIP-Seq_CD4+_Human1.24838619
80PIAS1_25552417_ChIP-Seq_VCAP_Human1.24557042
81EGR1_19032775_ChIP-ChIP_M12_Human1.24227630
82KDM2B_26808549_Chip-Seq_REH_Human1.22935973
83AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.22468329
84EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.20950178
85RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.20483953
86* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.20223446
87PCGF2_27294783_Chip-Seq_NPCs_Mouse1.19871891
88EZH2_27294783_Chip-Seq_NPCs_Mouse1.18425714
89AUTS2_25519132_ChIP-Seq_293T-REX_Human1.17559677
90PRDM14_20953172_ChIP-Seq_ESCs_Human1.17132533
91SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.16709673
92SUZ12_27294783_Chip-Seq_NPCs_Mouse1.16370121
93ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.16245073
94CBX2_27304074_Chip-Seq_ESCs_Mouse1.15897073
95ESR2_21235772_ChIP-Seq_MCF-7_Human1.13809335
96AR_21572438_ChIP-Seq_LNCaP_Human1.13610229
97BCAT_22108803_ChIP-Seq_LS180_Human1.11721661
98FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.10893531
99* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.10103171
100ERG_21242973_ChIP-ChIP_JURKAT_Human1.09495366
101SRF_21415370_ChIP-Seq_HL-1_Mouse1.09353425
102SOX2_21211035_ChIP-Seq_LN229_Gbm1.09207878
103HTT_18923047_ChIP-ChIP_STHdh_Human1.09032515
104ARNT_22903824_ChIP-Seq_MCF-7_Human1.08905109
105P53_22127205_ChIP-Seq_FIBROBLAST_Human1.08554513
106FLI1_21867929_ChIP-Seq_TH2_Mouse1.06866152
107MYC_18940864_ChIP-ChIP_HL60_Human1.06702280
108AR_20517297_ChIP-Seq_VCAP_Human1.06245584
109PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.06050750
110ETS1_20019798_ChIP-Seq_JURKAT_Human1.06038174
111GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.05286415
112SMAD3_21741376_ChIP-Seq_ESCs_Human1.04669576
113CTCF_27219007_Chip-Seq_Bcells_Human1.04202578
114TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01995257
115POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.01995257
116ETV2_25802403_ChIP-Seq_MESCs_Mouse1.01917264
117FOXA1_25329375_ChIP-Seq_VCAP_Human1.01829784
118FOXA1_27270436_Chip-Seq_PROSTATE_Human1.01829784
119NFE2_27457419_Chip-Seq_LIVER_Mouse1.01776655
120MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.01729551
121FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.01075618
122CRX_20693478_ChIP-Seq_RETINA_Mouse1.00964267
123SMAD4_21741376_ChIP-Seq_HESCs_Human1.00699245
124PADI4_21655091_ChIP-ChIP_MCF-7_Human1.00644648
125KLF5_20875108_ChIP-Seq_MESCs_Mouse1.00559273
126SMAD3_21741376_ChIP-Seq_EPCs_Human1.00218476
127NCOR_22424771_ChIP-Seq_293T_Human0.99336774
128FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.99235153
129RUNX2_22187159_ChIP-Seq_PCA_Human0.98414821
130* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.98094816
131BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.98091759
132CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.97804797
133EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.96097808
134* E2F1_18555785_Chip-Seq_ESCs_Mouse0.95514444
135GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95271155
136NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.94675458
137* TCF4_23295773_ChIP-Seq_U87_Human0.94490247
138RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.93816179
139ZNF274_21170338_ChIP-Seq_K562_Hela0.93600690
140DROSHA_22980978_ChIP-Seq_HELA_Human0.93508079
141* TCF4_22108803_ChIP-Seq_LS180_Human0.93132258
142TAL1_26923725_Chip-Seq_HPCs_Mouse0.93063628
143KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.92386487
144TP53_20018659_ChIP-ChIP_R1E_Mouse0.92345996
145* NANOG_18555785_Chip-Seq_ESCs_Mouse0.92204223
146OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.91125024
147YAP1_20516196_ChIP-Seq_MESCs_Mouse0.89769481
148RARB_27405468_Chip-Seq_BRAIN_Mouse0.89516371
149* POU3F2_20337985_ChIP-ChIP_501MEL_Human0.88332436
150ZNF263_19887448_ChIP-Seq_K562_Human0.87324130
151CMYC_18555785_Chip-Seq_ESCs_Mouse0.87227399
152STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.86864534
153EP300_21415370_ChIP-Seq_HL-1_Mouse0.86443122

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002735_abnormal_chemical_nociception7.84313775
2MP0001986_abnormal_taste_sensitivity6.42875843
3MP0001968_abnormal_touch/_nociception6.24228108
4MP0002736_abnormal_nociception_after5.90038213
5MP0004270_analgesia4.50254494
6MP0006276_abnormal_autonomic_nervous4.37872768
7MP0004858_abnormal_nervous_system4.07174128
8MP0002734_abnormal_mechanical_nocicepti4.02147251
9MP0002733_abnormal_thermal_nociception4.01568613
10MP0001970_abnormal_pain_threshold3.40912563
11MP0002102_abnormal_ear_morphology2.73310835
12MP0003195_calcinosis2.63009186
13MP0004215_abnormal_myocardial_fiber2.62159224
14MP0008877_abnormal_DNA_methylation2.56532154
15MP0004859_abnormal_synaptic_plasticity2.28357523
16MP0002184_abnormal_innervation2.20322168
17MP0003646_muscle_fatigue2.20124909
18MP0002272_abnormal_nervous_system2.13373125
19MP0002751_abnormal_autonomic_nervous2.12849675
20MP0002067_abnormal_sensory_capabilities2.07198129
21MP0005551_abnormal_eye_electrophysiolog1.97005403
22MP0003880_abnormal_central_pattern1.90788818
23MP0003122_maternal_imprinting1.88138581
24MP0002638_abnormal_pupillary_reflex1.86058882
25MP0003011_delayed_dark_adaptation1.84907356
26MP0005253_abnormal_eye_physiology1.84211317
27MP0006072_abnormal_retinal_apoptosis1.81428312
28MP0004084_abnormal_cardiac_muscle1.80071531
29MP0004510_myositis1.73899037
30MP0005084_abnormal_gallbladder_morpholo1.72962060
31MP0009046_muscle_twitch1.70632838
32MP0003787_abnormal_imprinting1.70212780
33MP0009780_abnormal_chondrocyte_physiolo1.62661677
34MP0003635_abnormal_synaptic_transmissio1.57053684
35MP0000516_abnormal_urinary_system1.56889769
36MP0005367_renal/urinary_system_phenotyp1.56889769
37MP0004147_increased_porphyrin_level1.50374245
38MP0000372_irregular_coat_pigmentation1.48475264
39MP0004811_abnormal_neuron_physiology1.48158780
40MP0003121_genomic_imprinting1.43284589
41MP0001348_abnormal_lacrimal_gland1.40653413
42MP0001984_abnormal_olfaction1.38379768
43MP0002090_abnormal_vision1.38181673
44MP0003183_abnormal_peptide_metabolism1.36972273
45MP0009745_abnormal_behavioral_response1.36719938
46MP0000955_abnormal_spinal_cord1.36075085
47MP0008260_abnormal_autophagy1.35162732
48MP0005360_urolithiasis1.33584935
49MP0002064_seizures1.32985058
50MP0005423_abnormal_somatic_nervous1.30455107
51MP0005646_abnormal_pituitary_gland1.30232008
52MP0004043_abnormal_pH_regulation1.30097602
53MP0008789_abnormal_olfactory_epithelium1.25541215
54MP0008995_early_reproductive_senescence1.24744807
55MP0009697_abnormal_copulation1.23383469
56MP0002572_abnormal_emotion/affect_behav1.23371964
57MP0003137_abnormal_impulse_conducting1.22429224
58MP0002063_abnormal_learning/memory/cond1.21091833
59MP0002234_abnormal_pharynx_morphology1.20054793
60MP0005499_abnormal_olfactory_system1.18404938
61MP0005394_taste/olfaction_phenotype1.18404938
62MP0003656_abnormal_erythrocyte_physiolo1.18151906
63MP0001440_abnormal_grooming_behavior1.17152616
64MP0001270_distended_abdomen1.16773160
65MP0006036_abnormal_mitochondrial_physio1.16125724
66MP0001188_hyperpigmentation1.14959454
67MP0005085_abnormal_gallbladder_physiolo1.14320300
68MP0006035_abnormal_mitochondrial_morpho1.14149946
69MP0005670_abnormal_white_adipose1.11875971
70MP0008875_abnormal_xenobiotic_pharmacok1.11415649
71MP0005083_abnormal_biliary_tract1.09938334
72MP0002882_abnormal_neuron_morphology1.08774155
73MP0003879_abnormal_hair_cell1.07718679
74MP0000778_abnormal_nervous_system1.03893734
75MP0004742_abnormal_vestibular_system1.03760007
76MP0003221_abnormal_cardiomyocyte_apopto1.02221101
77MP0002332_abnormal_exercise_endurance1.00826220
78MP0005365_abnormal_bile_salt1.00421135
79MP0008058_abnormal_DNA_repair1.00138960
80MP0010386_abnormal_urinary_bladder0.99280650
81MP0003786_premature_aging0.98196725
82MP0005187_abnormal_penis_morphology0.97314497
83MP0002229_neurodegeneration0.97001394
84MP0004133_heterotaxia0.96687542
85MP0001486_abnormal_startle_reflex0.95153922
86MP0004142_abnormal_muscle_tone0.94107461
87MP0002752_abnormal_somatic_nervous0.93813708
88MP0005330_cardiomyopathy0.92096334
89MP0000749_muscle_degeneration0.92056204
90MP0003718_maternal_effect0.91500000
91MP0003698_abnormal_male_reproductive0.90103389
92MP0001764_abnormal_homeostasis0.88998009
93MP0009379_abnormal_foot_pigmentation0.88706378
94MP0000049_abnormal_middle_ear0.86905200
95MP0005386_behavior/neurological_phenoty0.85699326
96MP0004924_abnormal_behavior0.85699326
97MP0002254_reproductive_system_inflammat0.85282108
98MP0005620_abnormal_muscle_contractility0.83802895
99MP0002557_abnormal_social/conspecific_i0.82626548
100MP0002066_abnormal_motor_capabilities/c0.79942900
101MP0003329_amyloid_beta_deposits0.78820230
102MP0001299_abnormal_eye_distance/0.77861150
103MP0002876_abnormal_thyroid_physiology0.77837500
104MP0005171_absent_coat_pigmentation0.77445387
105MP0001485_abnormal_pinna_reflex0.75725873
106MP0001963_abnormal_hearing_physiology0.75105468
107MP0001501_abnormal_sleep_pattern0.74804151
108MP0001905_abnormal_dopamine_level0.73990448
109MP0003634_abnormal_glial_cell0.73862278
110MP0008874_decreased_physiological_sensi0.73731431
111MP0003633_abnormal_nervous_system0.72932182
112MP0000427_abnormal_hair_cycle0.71564495
113MP0000015_abnormal_ear_pigmentation0.70913715
114MP0002160_abnormal_reproductive_system0.70507739
115MP0008569_lethality_at_weaning0.69640054
116MP0000751_myopathy0.67480739
117MP0005645_abnormal_hypothalamus_physiol0.66961797
118MP0000538_abnormal_urinary_bladder0.65201201
119MP0004036_abnormal_muscle_relaxation0.62431769
120MP0005410_abnormal_fertilization0.61406164
121MP0001502_abnormal_circadian_rhythm0.58615018
122MP0000920_abnormal_myelination0.58349422
123MP0002837_dystrophic_cardiac_calcinosis0.58315138
124MP0004145_abnormal_muscle_electrophysio0.57040357
125MP0003878_abnormal_ear_physiology0.56369451
126MP0005377_hearing/vestibular/ear_phenot0.56369451
127MP0003045_fibrosis0.56272552
128MP0008775_abnormal_heart_ventricle0.56055880
129MP0000534_abnormal_ureter_morphology0.55795031
130MP0010771_integument_phenotype0.55223112
131MP0004085_abnormal_heartbeat0.55189984
132MP0000681_abnormal_thyroid_gland0.54978053
133MP0003631_nervous_system_phenotype0.54593575
134MP0001542_abnormal_bone_strength0.54275993
135MP0005535_abnormal_body_temperature0.54212193
136MP0002163_abnormal_gland_morphology0.51201073
137MP0001664_abnormal_digestion0.50663969
138MP0002972_abnormal_cardiac_muscle0.49026557
139MP0002909_abnormal_adrenal_gland0.48348300
140MP0008872_abnormal_physiological_respon0.46591669
141MP0008004_abnormal_stomach_pH0.46532077
142MP0004883_abnormal_blood_vessel0.44709891
143MP0004484_altered_response_of0.39037554
144MP0000230_abnormal_systemic_arterial0.38688137
145MP0003315_abnormal_perineum_morphology0.38557460
146MP0001529_abnormal_vocalization0.37830349
147MP0002069_abnormal_eating/drinking_beha0.37724073
148MP0000604_amyloidosis0.37494882

Predicted human phenotypes

RankGene SetZ-score
1Ulnar claw (HP:0001178)8.36600022
2Myokymia (HP:0002411)7.37195598
3Segmental peripheral demyelination/remyelination (HP:0003481)4.96950271
4Pheochromocytoma (HP:0002666)4.96513224
5Termporal pattern (HP:0011008)4.88407803
6Insidious onset (HP:0003587)4.88407803
7Action tremor (HP:0002345)4.87652835
8Hypothermia (HP:0002045)4.76127209
9Neuroendocrine neoplasm (HP:0100634)4.69666233
10Dysautonomia (HP:0002459)4.51886341
11Impaired pain sensation (HP:0007328)4.45490711
12Abnormality of pain sensation (HP:0010832)4.45490711
13Febrile seizures (HP:0002373)4.28299659
14Steppage gait (HP:0003376)3.89324628
15Foot dorsiflexor weakness (HP:0009027)3.82694241
16Focal motor seizures (HP:0011153)3.81686403
17Atonic seizures (HP:0010819)3.80257693
18Myotonia (HP:0002486)3.78882361
19Distal arthrogryposis (HP:0005684)3.67397727
20Decreased number of peripheral myelinated nerve fibers (HP:0003380)3.62203242
21Submucous cleft hard palate (HP:0000176)3.54892885
22Hammertoe (HP:0001765)3.44404665
23Focal seizures (HP:0007359)3.38872467
24Abnormality of the foot musculature (HP:0001436)3.35742475
25Abnormal hair whorl (HP:0010721)3.33741857
26Acute necrotizing encephalopathy (HP:0006965)3.25833379
27Pancreatic cysts (HP:0001737)3.20858314
28Metaphyseal dysplasia (HP:0100255)3.12052215
29Bradycardia (HP:0001662)3.10120670
30Failure to thrive in infancy (HP:0001531)3.09473892
31Abnormal mitochondria in muscle tissue (HP:0008316)3.06592112
32Progressive cerebellar ataxia (HP:0002073)3.05072143
33Progressive macrocephaly (HP:0004481)3.02779771
34Acute encephalopathy (HP:0006846)2.97855908
35Abnormality of the labia minora (HP:0012880)2.96181517
36Abolished electroretinogram (ERG) (HP:0000550)2.88804557
37True hermaphroditism (HP:0010459)2.87353951
38Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.83790242
39Onion bulb formation (HP:0003383)2.81566499
40Increased CSF lactate (HP:0002490)2.72143989
41Pancreatic fibrosis (HP:0100732)2.71156403
42Distal sensory impairment (HP:0002936)2.70757956
43Hyperglycinemia (HP:0002154)2.69350132
44Abnormal autonomic nervous system physiology (HP:0012332)2.68753742
45Abnormality of the vocal cords (HP:0008777)2.68718879
46Supranuclear gaze palsy (HP:0000605)2.67998327
47Abnormality of glycine metabolism (HP:0010895)2.66475935
48Abnormality of serine family amino acid metabolism (HP:0010894)2.66475935
49Neoplasm of the peripheral nervous system (HP:0100007)2.63320595
50Ankle clonus (HP:0011448)2.62642115
51Mitochondrial inheritance (HP:0001427)2.62262701
52Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.60571424
53Abnormality of magnesium homeostasis (HP:0004921)2.59493750
54Chin dimple (HP:0010751)2.59079308
55Aplasia/Hypoplasia of the brainstem (HP:0007362)2.57285179
56Hypoplasia of the brainstem (HP:0002365)2.57285179
57Thoracolumbar scoliosis (HP:0002944)2.56950320
58Decreased motor nerve conduction velocity (HP:0003431)2.56404115
59Abnormal hemoglobin (HP:0011902)2.55254518
60Hyperglycinuria (HP:0003108)2.54744562
61Attenuation of retinal blood vessels (HP:0007843)2.54049938
62Abnormality of macular pigmentation (HP:0008002)2.54041542
63Medial flaring of the eyebrow (HP:0010747)2.53202600
64Areflexia of lower limbs (HP:0002522)2.53176253
65Autoamputation (HP:0001218)2.52423974
66Hypercortisolism (HP:0001578)2.48529540
67Unilateral renal agenesis (HP:0000122)2.47507539
68Impaired proprioception (HP:0010831)2.46765923
69Methylmalonic acidemia (HP:0002912)2.45493530
70Progressive inability to walk (HP:0002505)2.45419691
71Absent eyebrow (HP:0002223)2.43941098
72Thyroid carcinoma (HP:0002890)2.43238753
73Hemiparesis (HP:0001269)2.42372098
74Hypomagnesemia (HP:0002917)2.42041102
75Hepatic necrosis (HP:0002605)2.39512468
76Cortical dysplasia (HP:0002539)2.39215375
77Drooling (HP:0002307)2.38033606
78Exercise-induced muscle cramps (HP:0003710)2.37227299
79Lissencephaly (HP:0001339)2.35920699
80Urinary urgency (HP:0000012)2.34640165
81Absence seizures (HP:0002121)2.33267914
82Abnormality of the calf musculature (HP:0001430)2.32523813
83Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.30930475
84Decreased activity of mitochondrial respiratory chain (HP:0008972)2.30930475
85Hepatocellular necrosis (HP:0001404)2.29584971
86Abnormality of the corticospinal tract (HP:0002492)2.27482313
87Aplasia/hypoplasia of the uterus (HP:0008684)2.27226726
88Nephronophthisis (HP:0000090)2.25120482
89Distal lower limb muscle weakness (HP:0009053)2.24999542
90Dialeptic seizures (HP:0011146)2.24749287
91Abnormality of midbrain morphology (HP:0002418)2.23340531
92Molar tooth sign on MRI (HP:0002419)2.23340531
93Hyporeflexia of lower limbs (HP:0002600)2.22743220
94Gait imbalance (HP:0002141)2.22021306
95Retinal dysplasia (HP:0007973)2.21535251
96Decreased muscle mass (HP:0003199)2.21321295
97Optic disc pallor (HP:0000543)2.20449659
98Abnormality of dental color (HP:0011073)2.19451831
99Type II lissencephaly (HP:0007260)2.18742204
100Pachygyria (HP:0001302)2.18106632
101Cerebral edema (HP:0002181)2.17711627
102Abnormality of calcium-phosphate metabolism (HP:0100530)2.17476044
103Neonatal respiratory distress (HP:0002643)2.17234192
104Delayed CNS myelination (HP:0002188)2.15065692
105Chronic hepatic failure (HP:0100626)2.12431300
106Follicular hyperkeratosis (HP:0007502)2.11817719
107Hypoventilation (HP:0002791)2.11126245
108Epileptic encephalopathy (HP:0200134)2.11002546
109Lactic acidosis (HP:0003128)2.09853377
110Congenital primary aphakia (HP:0007707)2.08696989
111Aplasia/Hypoplasia of the tibia (HP:0005772)2.08552322
112Excessive salivation (HP:0003781)2.08517718
113Generalized tonic-clonic seizures (HP:0002069)2.08467928
114Sensory axonal neuropathy (HP:0003390)2.07701680
115Methylmalonic aciduria (HP:0012120)2.07503888
116Spastic tetraplegia (HP:0002510)2.05878069
117Decreased central vision (HP:0007663)2.05522732
118Parakeratosis (HP:0001036)2.05267374
119Colon cancer (HP:0003003)2.05033380
120Polyphagia (HP:0002591)2.04723565
121Ketoacidosis (HP:0001993)2.04030150
122Absent phalangeal crease (HP:0006109)2.03919052
123Limb dystonia (HP:0002451)2.03521194
124Inability to walk (HP:0002540)2.02527878
125Calf muscle hypertrophy (HP:0008981)2.00739253
126Urinary bladder sphincter dysfunction (HP:0002839)2.00044108
127Nephrogenic diabetes insipidus (HP:0009806)1.98283545
128Truncal ataxia (HP:0002078)1.97798976
129Popliteal pterygium (HP:0009756)1.97754815
130Abnormality of the epiphysis of the femoral head (HP:0010574)1.96796050
131Spinal canal stenosis (HP:0003416)1.96682557
132Overlapping toe (HP:0001845)1.96074959
133Spastic gait (HP:0002064)1.95729075
134Thyroid-stimulating hormone excess (HP:0002925)1.95555839
135Increased corneal curvature (HP:0100692)1.94541727
136Keratoconus (HP:0000563)1.94541727
137Abnormality of the renal cortex (HP:0011035)1.94242232
138Fetal akinesia sequence (HP:0001989)1.94114868
139Ketosis (HP:0001946)1.93908056
140Short tibia (HP:0005736)1.93701430
141Cerebral hemorrhage (HP:0001342)1.93670160
142Arthropathy (HP:0003040)1.93619651
143Alopecia of scalp (HP:0002293)1.93442944
144Tubular atrophy (HP:0000092)1.91802404
145Poor suck (HP:0002033)1.90936585
146Amyotrophic lateral sclerosis (HP:0007354)1.89759992
147Decreased electroretinogram (ERG) amplitude (HP:0000654)1.89668725
148Muscle stiffness (HP:0003552)1.88931420
149Chorioretinal atrophy (HP:0000533)1.88894072
150Curly hair (HP:0002212)1.88630257
151Scanning speech (HP:0002168)1.87821391
152Renal dysplasia (HP:0000110)1.87618595
153Abnormality of the femoral head (HP:0003368)1.86628597
154Abnormality of serum amino acid levels (HP:0003112)1.86170489
155Postural tremor (HP:0002174)1.85860497
156Facial shape deformation (HP:0011334)1.85689934
157Potter facies (HP:0002009)1.85689934
158Increased serum lactate (HP:0002151)1.85676306
159Hyperalaninemia (HP:0003348)1.85395469
160Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.85395469
161Abnormality of alanine metabolism (HP:0010916)1.85395469
162Hepatoblastoma (HP:0002884)1.84175550
163Anosmia (HP:0000458)1.82300130
164Mask-like facies (HP:0000298)1.81811343
165Recurrent corneal erosions (HP:0000495)1.81240178
166Amblyopia (HP:0000646)1.81020130
167Respiratory failure (HP:0002878)1.80880877
168Akinesia (HP:0002304)1.80808631
169Hypsarrhythmia (HP:0002521)1.80712527
170Down-sloping shoulders (HP:0200021)1.80624536
171Vaginal atresia (HP:0000148)1.80544262
172Renal cortical cysts (HP:0000803)1.80185905
173Genital tract atresia (HP:0001827)1.80135162
174Left ventricular hypertrophy (HP:0001712)1.80113966
175Upper limb muscle weakness (HP:0003484)1.80092194
176Bony spicule pigmentary retinopathy (HP:0007737)1.79264151
177Abnormality of femoral epiphyses (HP:0006499)1.78368636
178Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.78368636
179Axonal loss (HP:0003447)1.78231300
180Cutaneous finger syndactyly (HP:0010554)1.78058645
181Lower limb muscle weakness (HP:0007340)1.77854391
182Muscle hypertrophy of the lower extremities (HP:0008968)1.77603201
183Lipid accumulation in hepatocytes (HP:0006561)1.76465178
184Bundle branch block (HP:0011710)1.76418780
185Abnormality of glycolysis (HP:0004366)1.76145010
186Abnormality of the renal medulla (HP:0100957)1.74847580
187Sudden death (HP:0001699)1.73892664
188Increased hepatocellular lipid droplets (HP:0006565)1.73766940
189Congenital stationary night blindness (HP:0007642)1.73632425
190Exercise intolerance (HP:0003546)1.73072275
191Muscular hypotonia of the trunk (HP:0008936)1.72165573
192Proximal amyotrophy (HP:0007126)1.71488239

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SIK33.95895924
2TRIM283.61231009
3GRK53.55178735
4LMTK23.39851039
5MINK13.34539297
6NTRK33.28587801
7LIMK13.26003727
8NTRK13.15546148
9MAP3K123.09249322
10CASK3.01048546
11MAP4K22.85563943
12KSR22.76238415
13ERBB32.75021825
14MAP3K92.74888336
15MAP3K22.45231775
16SRPK12.38083484
17WNK32.29866953
18LATS22.15108111
19ARAF1.93333782
20MAPKAPK31.91096009
21RIPK41.85750360
22BRD41.84020052
23PAK31.81869040
24MATK1.71380435
25RET1.71223389
26EPHA31.65507883
27TNIK1.60512405
28GRK11.60096518
29MAP2K71.59009560
30MAPK131.58336179
31MARK31.57954501
32PDK21.57065805
33PHKG21.56574139
34PHKG11.56574139
35OBSCN1.50969876
36SGK21.48389611
37SGK4941.44486617
38SGK2231.44486617
39NUAK11.40071851
40MAP2K41.40059699
41CSNK1G11.37530167
42ADRBK21.32909947
43BMPR1B1.31487262
44FER1.30765314
45NEK11.28329432
46WNK11.25538183
47MAP3K41.24567386
48MAP2K11.23692311
49OXSR11.18266231
50NEK91.16136892
51RPS6KA21.13907986
52BCR1.12415051
53CDK191.10634697
54PLK41.08165390
55ZAK1.07232909
56STK391.05929766
57MAP3K11.03923236
58RPS6KA41.01275681
59TESK10.98479496
60BCKDK0.98052319
61YES10.94601318
62DAPK20.93897076
63ADRBK10.93796209
64TNK20.91459062
65SGK30.91333675
66PAK60.88359672
67FGFR20.88292367
68EIF2AK30.87862887
69NME10.86577653
70CAMKK20.85950281
71WNK40.85873902
72PIM20.84607324
73PINK10.81260763
74PLK20.78987598
75STK160.78254311
76MAP2K20.78015749
77MST40.77530512
78INSRR0.75387192
79PRPF4B0.74337496
80PIK3CG0.73911536
81CDK50.72483013
82PRKCE0.70702995
83PRKG20.70332426
84MARK10.69548823
85PLK30.67022517
86PRKCG0.64196464
87MAP2K60.61288868
88AKT30.59455882
89RPS6KA50.59374119
90PIK3CA0.59084078
91BRAF0.57888024
92CDK140.57663372
93NTRK20.56164926
94PRKAA10.55500115
95CAMK2B0.55384035
96DYRK30.54677331
97MUSK0.52342943
98PLK10.51941909
99FGFR30.51781176
100TLK10.51389475
101MKNK20.48322951
102VRK10.48307079
103NEK60.48259860
104PKN10.47381815
105STK38L0.45130529
106SCYL20.44674606
107STK240.44498102
108SIK20.44019808
109DYRK20.42931780
110EPHB20.42907636
111MAP3K110.42319020
112CAMK40.42155663
113PTK2B0.39362042
114CDK80.38435518
115CAMK2A0.38385254
116UHMK10.38300617
117BLK0.36973235
118TRPM70.36637715
119EPHA40.36384062
120ACVR1B0.36076201
121CSNK1D0.35977602
122IRAK10.35749820
123ATM0.35371059
124GRK70.35218580
125FRK0.35042240
126CSNK1G20.34605326
127KSR10.34553284
128DYRK1B0.34312674
129DAPK10.34055938
130CSNK1A10.33804062
131MAP3K60.33425322
132MYLK0.33038293
133CAMK10.32140928
134* PRKACA0.32116874
135CAMKK10.31535003
136TIE10.31073833
137PDK10.30960637
138CAMK2G0.30659893
139TAOK30.30607658
140MKNK10.29832863
141PRKCH0.29160486
142AURKA0.28930726
143PRKG10.28228212
144CSNK1G30.27819541
145CDK180.27671568
146PRKACG0.27438570
147MAPKAPK50.27110094
148PDK30.26925665
149PDK40.26925665
150CAMK2D0.26864092
151PDPK10.26822732
152CSNK1A1L0.23684456
153ROCK10.23415133
154RPS6KB10.23237123

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047213.92314709
2Vasopressin-regulated water reabsorption_Homo sapiens_hsa049623.48904061
3Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049613.00964263
4Taste transduction_Homo sapiens_hsa047422.66164292
5Butanoate metabolism_Homo sapiens_hsa006502.58481564
6Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050142.37290248
7Oxidative phosphorylation_Homo sapiens_hsa001902.28553319
8Olfactory transduction_Homo sapiens_hsa047402.27771315
9Collecting duct acid secretion_Homo sapiens_hsa049662.19101683
10Protein export_Homo sapiens_hsa030602.11633094
11Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049602.11352739
12Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.08955597
13Parkinsons disease_Homo sapiens_hsa050122.00900945
14SNARE interactions in vesicular transport_Homo sapiens_hsa041301.94628949
15Primary bile acid biosynthesis_Homo sapiens_hsa001201.93596452
16Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.88866303
17Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.87263361
18Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.85549186
19Propanoate metabolism_Homo sapiens_hsa006401.84464963
20Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.78966063
21Insulin secretion_Homo sapiens_hsa049111.78908792
22Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.76675160
23Cardiac muscle contraction_Homo sapiens_hsa042601.67851551
24Peroxisome_Homo sapiens_hsa041461.63599479
25Serotonergic synapse_Homo sapiens_hsa047261.60226187
26Thyroid cancer_Homo sapiens_hsa052161.58570624
27Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.58081867
28Alzheimers disease_Homo sapiens_hsa050101.56038001
29Regulation of autophagy_Homo sapiens_hsa041401.55360093
30Dopaminergic synapse_Homo sapiens_hsa047281.50899311
31Dorso-ventral axis formation_Homo sapiens_hsa043201.48359237
32Cholinergic synapse_Homo sapiens_hsa047251.42669918
33Melanoma_Homo sapiens_hsa052181.42111437
34Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.41450060
35Circadian entrainment_Homo sapiens_hsa047131.38999015
36Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.36468894
37Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.35694373
38Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.32804496
39Linoleic acid metabolism_Homo sapiens_hsa005911.32688674
40Circadian rhythm_Homo sapiens_hsa047101.32674283
41Huntingtons disease_Homo sapiens_hsa050161.31639041
42beta-Alanine metabolism_Homo sapiens_hsa004101.31342151
43Phagosome_Homo sapiens_hsa041451.30629190
44Ether lipid metabolism_Homo sapiens_hsa005651.27913190
45Salmonella infection_Homo sapiens_hsa051321.26958257
46Nicotine addiction_Homo sapiens_hsa050331.26749630
47Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.25635525
48Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.25452722
49Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.24680548
50Tryptophan metabolism_Homo sapiens_hsa003801.22661486
51Salivary secretion_Homo sapiens_hsa049701.21835552
52Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.21744516
53Long-term potentiation_Homo sapiens_hsa047201.21147095
54Phosphatidylinositol signaling system_Homo sapiens_hsa040701.20602616
55Neurotrophin signaling pathway_Homo sapiens_hsa047221.19981175
56Glutamatergic synapse_Homo sapiens_hsa047241.19800270
57Vibrio cholerae infection_Homo sapiens_hsa051101.15139975
58RNA degradation_Homo sapiens_hsa030181.14888646
59Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.12263757
60Steroid biosynthesis_Homo sapiens_hsa001001.12243026
61Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.11838348
62Basal transcription factors_Homo sapiens_hsa030221.11405262
63Morphine addiction_Homo sapiens_hsa050321.11296668
64RNA polymerase_Homo sapiens_hsa030201.11217012
65Vitamin B6 metabolism_Homo sapiens_hsa007501.10468759
662-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.10305198
67Cysteine and methionine metabolism_Homo sapiens_hsa002701.08749660
68Selenocompound metabolism_Homo sapiens_hsa004501.07734766
69Fatty acid metabolism_Homo sapiens_hsa012121.07296798
70Phototransduction_Homo sapiens_hsa047441.07020165
71Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.06399627
72Fanconi anemia pathway_Homo sapiens_hsa034601.03582353
73Fatty acid degradation_Homo sapiens_hsa000711.03245390
74Rheumatoid arthritis_Homo sapiens_hsa053231.02882895
75Mineral absorption_Homo sapiens_hsa049781.01137073
76Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.00976059
77GABAergic synapse_Homo sapiens_hsa047270.99706058
78Caffeine metabolism_Homo sapiens_hsa002320.99544937
79Arginine and proline metabolism_Homo sapiens_hsa003300.98118012
80Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.97725379
81Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.97597913
82ErbB signaling pathway_Homo sapiens_hsa040120.97428213
83alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.96317739
84GnRH signaling pathway_Homo sapiens_hsa049120.95440833
85Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.95403852
86Prolactin signaling pathway_Homo sapiens_hsa049170.94421124
87Calcium signaling pathway_Homo sapiens_hsa040200.94110141
88Fatty acid biosynthesis_Homo sapiens_hsa000610.93786051
89Glioma_Homo sapiens_hsa052140.93499574
90Steroid hormone biosynthesis_Homo sapiens_hsa001400.93417296
91Retinol metabolism_Homo sapiens_hsa008300.87289224
92RNA transport_Homo sapiens_hsa030130.86962082
93Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.85472849
94Endometrial cancer_Homo sapiens_hsa052130.85379577
95Long-term depression_Homo sapiens_hsa047300.85233933
96Insulin signaling pathway_Homo sapiens_hsa049100.84939825
97Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.82179059
98Metabolic pathways_Homo sapiens_hsa011000.80611625
99Pentose and glucuronate interconversions_Homo sapiens_hsa000400.80503696
100Homologous recombination_Homo sapiens_hsa034400.79661982
101Axon guidance_Homo sapiens_hsa043600.79471002
102Non-homologous end-joining_Homo sapiens_hsa034500.79470567
103Maturity onset diabetes of the young_Homo sapiens_hsa049500.77462923
104One carbon pool by folate_Homo sapiens_hsa006700.77373650
105Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.77350350
106Chemical carcinogenesis_Homo sapiens_hsa052040.77308989
107Gastric acid secretion_Homo sapiens_hsa049710.76417150
108Gap junction_Homo sapiens_hsa045400.76298665
109Endocytosis_Homo sapiens_hsa041440.75389889
110Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.72333097
111Carbohydrate digestion and absorption_Homo sapiens_hsa049730.71852080
112Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.71606415
113Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.70997785
114Carbon metabolism_Homo sapiens_hsa012000.70793134
115Dilated cardiomyopathy_Homo sapiens_hsa054140.69313954
116Ras signaling pathway_Homo sapiens_hsa040140.67917575
117Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.67856302
118Nitrogen metabolism_Homo sapiens_hsa009100.66704826
119Central carbon metabolism in cancer_Homo sapiens_hsa052300.66554632
120Melanogenesis_Homo sapiens_hsa049160.65658990
121Proteasome_Homo sapiens_hsa030500.63435333
122Mismatch repair_Homo sapiens_hsa034300.62608180
123Glutathione metabolism_Homo sapiens_hsa004800.62332536
124Type II diabetes mellitus_Homo sapiens_hsa049300.62322371
125VEGF signaling pathway_Homo sapiens_hsa043700.62244216
126Sphingolipid signaling pathway_Homo sapiens_hsa040710.62138909
127Renin secretion_Homo sapiens_hsa049240.62003934
128Biosynthesis of amino acids_Homo sapiens_hsa012300.62002015
129Oocyte meiosis_Homo sapiens_hsa041140.60848568
130Aldosterone synthesis and secretion_Homo sapiens_hsa049250.60733102
131Sulfur metabolism_Homo sapiens_hsa009200.60684448
132Phospholipase D signaling pathway_Homo sapiens_hsa040720.60232125
133Purine metabolism_Homo sapiens_hsa002300.59787677
134Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.59741821
135Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.58934782
136Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.58442092
137Arginine biosynthesis_Homo sapiens_hsa002200.58080100
138Phenylalanine metabolism_Homo sapiens_hsa003600.57628703
139Fat digestion and absorption_Homo sapiens_hsa049750.57144916
140MAPK signaling pathway_Homo sapiens_hsa040100.56944524
141Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.56562305
142Arachidonic acid metabolism_Homo sapiens_hsa005900.56313397
143Amphetamine addiction_Homo sapiens_hsa050310.55492780
144Oxytocin signaling pathway_Homo sapiens_hsa049210.54720105
145Hedgehog signaling pathway_Homo sapiens_hsa043400.53250313
146Rap1 signaling pathway_Homo sapiens_hsa040150.52753507
147Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.52662259
148mRNA surveillance pathway_Homo sapiens_hsa030150.52313820
149Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.51233413
150Estrogen signaling pathway_Homo sapiens_hsa049150.51135843
151Choline metabolism in cancer_Homo sapiens_hsa052310.50367424
152Vascular smooth muscle contraction_Homo sapiens_hsa042700.49753735
153Thyroid hormone synthesis_Homo sapiens_hsa049180.48612750
154Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.48031830
155Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.47929340
156Pancreatic secretion_Homo sapiens_hsa049720.47920983
157Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.47393037
158Renin-angiotensin system_Homo sapiens_hsa046140.46016761
159Pyruvate metabolism_Homo sapiens_hsa006200.44813370
160cAMP signaling pathway_Homo sapiens_hsa040240.44068569
161Fatty acid elongation_Homo sapiens_hsa000620.43169682
162Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.41624784
163Tuberculosis_Homo sapiens_hsa051520.37927821
164Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.37389022
165cGMP-PKG signaling pathway_Homo sapiens_hsa040220.36566847
166Pertussis_Homo sapiens_hsa051330.31916026
167PI3K-Akt signaling pathway_Homo sapiens_hsa041510.31177933
168Prion diseases_Homo sapiens_hsa050200.27865714

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »