PPP1R26

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1polyketide metabolic process (GO:0030638)9.61579103
2doxorubicin metabolic process (GO:0044598)9.61579103
3daunorubicin metabolic process (GO:0044597)9.61579103
4aminoglycoside antibiotic metabolic process (GO:0030647)6.13157126
5somite rostral/caudal axis specification (GO:0032525)5.45467928
6maintenance of protein location in nucleus (GO:0051457)5.31914119
7proline transport (GO:0015824)5.25334551
8regulation of mammary gland epithelial cell proliferation (GO:0033599)5.20900140
9histone H4-K5 acetylation (GO:0043981)4.99073127
10histone H4-K8 acetylation (GO:0043982)4.99073127
11negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)4.91482365
12synaptic vesicle maturation (GO:0016188)4.91053456
13negative regulation of epidermis development (GO:0045683)4.90291076
14regulation of response to osmotic stress (GO:0047484)4.70063655
15histone H4-K12 acetylation (GO:0043983)4.60364559
16regulation of cilium movement (GO:0003352)4.49951257
17planar cell polarity pathway involved in neural tube closure (GO:0090179)4.44248367
18regulation of telomere maintenance via telomerase (GO:0032210)4.37164383
19negative regulation of cell cycle G2/M phase transition (GO:1902750)4.36897182
20response to dietary excess (GO:0002021)4.18526779
21negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)4.14312774
22regulation of nuclear cell cycle DNA replication (GO:0033262)4.02850071
23regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)4.00567397
24cytoskeletal anchoring at plasma membrane (GO:0007016)3.95692437
25negative regulation of telomerase activity (GO:0051974)3.94264195
26histone H4-K16 acetylation (GO:0043984)3.89461595
27regulation of MHC class I biosynthetic process (GO:0045343)3.86231191
28phenol-containing compound catabolic process (GO:0019336)3.79588663
29primitive streak formation (GO:0090009)3.78159907
30mitochondrion distribution (GO:0048311)3.76545926
31rRNA transcription (GO:0009303)3.70779464
32protein localization to kinetochore (GO:0034501)3.70126912
33negative regulation of epidermal cell differentiation (GO:0045605)3.69567260
34muscle organ morphogenesis (GO:0048644)3.69065750
35notochord development (GO:0030903)3.61175756
36pre-miRNA processing (GO:0031054)3.55509014
37protein retention in ER lumen (GO:0006621)3.54841346
38regulation of microtubule-based movement (GO:0060632)3.53096438
39regulation of translational fidelity (GO:0006450)3.52529316
40cell-cell junction maintenance (GO:0045217)3.51315159
41microtubule severing (GO:0051013)3.49769040
42ventricular system development (GO:0021591)3.47918458
43negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.43683630
44paraxial mesoderm development (GO:0048339)3.42215551
45maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.41842406
46semaphorin-plexin signaling pathway (GO:0071526)3.38633439
47mitotic sister chromatid segregation (GO:0000070)3.38339033
48protein polyglutamylation (GO:0018095)3.37347521
49epithelial cell-cell adhesion (GO:0090136)3.34314608
50L-serine metabolic process (GO:0006563)3.31596923
51tachykinin receptor signaling pathway (GO:0007217)3.31553630
52regulation of telomere maintenance (GO:0032204)3.28476826
53positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.28006403
54convergent extension (GO:0060026)3.25951653
55regulation of short-term neuronal synaptic plasticity (GO:0048172)3.24962134
56adherens junction assembly (GO:0034333)3.24342648
57cell fate commitment involved in formation of primary germ layer (GO:0060795)3.24257492
58hormone catabolic process (GO:0042447)3.23756810
59COPI coating of Golgi vesicle (GO:0048205)3.21748956
60Golgi transport vesicle coating (GO:0048200)3.21748956
61heterochromatin organization (GO:0070828)3.21114981
62calcium-mediated signaling using intracellular calcium source (GO:0035584)3.19577432
63nucleoside transmembrane transport (GO:1901642)3.18401431
64DNA unwinding involved in DNA replication (GO:0006268)3.16446015
65branching involved in mammary gland duct morphogenesis (GO:0060444)3.14869296
66glutamate secretion (GO:0014047)3.13611571
67vocalization behavior (GO:0071625)3.13574865
68establishment of apical/basal cell polarity (GO:0035089)3.11296763
69negative regulation of telomere maintenance (GO:0032205)3.05538046
70neural tube development (GO:0021915)3.02275325
71layer formation in cerebral cortex (GO:0021819)3.01667546
72Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.00541205
73retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.00226026
74maintenance of protein localization in organelle (GO:0072595)2.99368337
75quinone metabolic process (GO:1901661)2.97448299
76positive regulation of DNA-dependent DNA replication (GO:2000105)2.95895644
77detection of temperature stimulus (GO:0016048)2.95808787
78regulation of intracellular estrogen receptor signaling pathway (GO:0033146)2.95322475
79negative regulation of potassium ion transmembrane transport (GO:1901380)2.94942483
80cardiovascular system development (GO:0072358)2.94311852
81regulation of early endosome to late endosome transport (GO:2000641)2.92939200
82cell-substrate adherens junction assembly (GO:0007045)2.92893092
83focal adhesion assembly (GO:0048041)2.92893092
84cytidine metabolic process (GO:0046087)2.92848241
85cytidine catabolic process (GO:0006216)2.92848241
86cytidine deamination (GO:0009972)2.92848241
87protein complex localization (GO:0031503)2.91239738
88desmosome organization (GO:0002934)2.90861410
89regulation of apoptotic process involved in morphogenesis (GO:1902337)2.89241201
90regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.87852596
91cell junction maintenance (GO:0034331)2.87602737
92intestinal epithelial cell development (GO:0060576)2.87579725
93negative regulation of cell size (GO:0045792)2.87186688
94proline biosynthetic process (GO:0006561)2.86281826
95activation of Rac GTPase activity (GO:0032863)2.85689934
96sister chromatid segregation (GO:0000819)2.84861173
97rRNA methylation (GO:0031167)2.84805270
98locomotory exploration behavior (GO:0035641)2.81858795
99neuron cell-cell adhesion (GO:0007158)2.81747408
100positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.80204396
101regulation of establishment of planar polarity (GO:0090175)2.80200926
102coenzyme catabolic process (GO:0009109)2.77972931
103positive regulation of synapse maturation (GO:0090129)2.77472153
104bone trabecula formation (GO:0060346)2.76989003
105dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.76015498
106apoptotic process involved in morphogenesis (GO:0060561)2.74326976
107chromatin assembly (GO:0031497)2.73764257
108stress granule assembly (GO:0034063)2.72035986
109peptidyl-arginine omega-N-methylation (GO:0035247)2.71433342
110regulation of NFAT protein import into nucleus (GO:0051532)2.71144705
111mitotic chromosome condensation (GO:0007076)2.70098375
112cerebral cortex neuron differentiation (GO:0021895)2.69683162
113branching involved in salivary gland morphogenesis (GO:0060445)2.68087121
114cell migration involved in gastrulation (GO:0042074)2.67984196
115regulation of odontogenesis of dentin-containing tooth (GO:0042487)2.67717575
116interferon-gamma production (GO:0032609)2.67560788
117cerebellar granule cell differentiation (GO:0021707)2.67521710
118protein localization to synapse (GO:0035418)2.66478442
119anterior/posterior axis specification (GO:0009948)2.65691753
120apical protein localization (GO:0045176)2.65520377
121maternal placenta development (GO:0001893)2.62045378
122negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.61707498
123protein-DNA complex disassembly (GO:0032986)2.60990708
124nucleosome disassembly (GO:0006337)2.60990708
125regulation of glucose import in response to insulin stimulus (GO:2001273)2.59973478
126synaptic vesicle docking involved in exocytosis (GO:0016081)2.59195210
127DNA replication-dependent nucleosome assembly (GO:0006335)2.58465746
128DNA replication-dependent nucleosome organization (GO:0034723)2.58465746
129mitochondrion localization (GO:0051646)2.58406695
130negative regulation of catenin import into nucleus (GO:0035414)2.58233188
131basement membrane organization (GO:0071711)2.58201938
132negative regulation of smoothened signaling pathway (GO:0045879)2.58110384
133synaptic vesicle exocytosis (GO:0016079)2.57918253
134phosphatidylinositol 3-kinase signaling (GO:0014065)2.57647768
135establishment or maintenance of monopolar cell polarity (GO:0061339)2.56885731
136establishment of monopolar cell polarity (GO:0061162)2.56885731
137regulation of synaptic vesicle exocytosis (GO:2000300)2.55928770
138hemidesmosome assembly (GO:0031581)2.54433836
139regulation of glutamate receptor signaling pathway (GO:1900449)2.53556103
140establishment or maintenance of bipolar cell polarity (GO:0061245)2.53492111
141establishment or maintenance of apical/basal cell polarity (GO:0035088)2.53492111
142cell migration in hindbrain (GO:0021535)2.53469486
143embryonic axis specification (GO:0000578)2.52875520
144cell-substrate junction assembly (GO:0007044)2.51861802
145positive regulation of muscle cell apoptotic process (GO:0010661)2.50964336
146cellular protein complex localization (GO:0034629)2.50468838
147regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.50397561
148protein localization to endosome (GO:0036010)2.50238261
149camera-type eye morphogenesis (GO:0048593)2.50090326
150nuclear pore complex assembly (GO:0051292)2.49846050
151protein localization to chromosome, centromeric region (GO:0071459)2.49636740
152asymmetric protein localization (GO:0008105)2.48997723
153negative regulation of peptidyl-serine phosphorylation (GO:0033137)2.48956561
154icosanoid secretion (GO:0032309)2.47610116
155histone arginine methylation (GO:0034969)2.46351956
156establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.41961145
157regulation of cholesterol biosynthetic process (GO:0045540)2.41363419
158protein localization to microtubule (GO:0035372)2.41116718
159non-canonical Wnt signaling pathway (GO:0035567)2.40559556
160endothelial cell chemotaxis (GO:0035767)2.40470653
161epithelial cell differentiation involved in prostate gland development (GO:0060742)2.38982945
162glucose 6-phosphate metabolic process (GO:0051156)2.35369514
163hippo signaling (GO:0035329)2.34957982
164peptidyl-lysine dimethylation (GO:0018027)2.32520725
165eye morphogenesis (GO:0048592)2.30079170
166cellular component maintenance (GO:0043954)2.28580435
167lung epithelium development (GO:0060428)2.28395271
168mitochondrion transport along microtubule (GO:0047497)2.27606515
169establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.27606515
170atrioventricular valve morphogenesis (GO:0003181)2.27568493
171cochlea morphogenesis (GO:0090103)2.27437235
172regulation of catenin import into nucleus (GO:0035412)2.25895343
173mating behavior (GO:0007617)2.24791559
174gap junction assembly (GO:0016264)2.24729911
175peptidyl-arginine N-methylation (GO:0035246)2.24030301
176peptidyl-arginine methylation (GO:0018216)2.24030301
177embryonic eye morphogenesis (GO:0048048)2.23871669
178embryonic retina morphogenesis in camera-type eye (GO:0060059)2.21280750
179spliceosomal tri-snRNP complex assembly (GO:0000244)2.21017616
180G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.19749626
181RNA localization (GO:0006403)2.18454534
182cerebellar Purkinje cell layer development (GO:0021680)2.17916423
183skeletal muscle organ development (GO:0060538)2.17385488
184neuromuscular process controlling balance (GO:0050885)2.17033445
185body morphogenesis (GO:0010171)2.15962099
186bundle of His cell to Purkinje myocyte communication (GO:0086069)2.15780855
187negative regulation of cell fate specification (GO:0009996)2.13862582
188proline metabolic process (GO:0006560)2.11810275
189insulin-like growth factor receptor signaling pathway (GO:0048009)2.09702565
190positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.09177350
191neuronal ion channel clustering (GO:0045161)2.09026289

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KLF5_18264089_ChIP-ChIP_MESCs_Mouse5.46353016
2KLF4_18264089_ChIP-ChIP_MESCs_Mouse5.46353016
3KLF2_18264089_ChIP-ChIP_MESCs_Mouse5.46353016
4BP1_19119308_ChIP-ChIP_Hs578T_Human4.55200987
5EZH2_22144423_ChIP-Seq_EOC_Human3.28528103
6TP63_17297297_ChIP-ChIP_HaCaT_Human3.27970074
7NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.99418729
8SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.94768543
9TP63_19390658_ChIP-ChIP_HaCaT_Human2.93176801
10NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.86020366
11SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.73683719
12E2F7_22180533_ChIP-Seq_HELA_Human2.67461976
13ZNF263_19887448_ChIP-Seq_K562_Human2.63817776
14LXR_22292898_ChIP-Seq_THP-1_Human2.41297250
15ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.28471079
16RACK7_27058665_Chip-Seq_MCF-7_Human2.25755963
17THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.21336747
18GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.17909908
19TCF3_18692474_ChIP-Seq_MESCs_Mouse2.14448966
20ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.12730899
21RARG_19884340_ChIP-ChIP_MEFs_Mouse2.10883914
22SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.06977569
23ESR2_21235772_ChIP-Seq_MCF-7_Human2.02417220
24IKZF1_21737484_ChIP-ChIP_HCT116_Human2.01514192
25EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.99978707
26ZFP281_18757296_ChIP-ChIP_E14_Mouse1.95176744
27FOXM1_23109430_ChIP-Seq_U2OS_Human1.93896878
28NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.92963974
29NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.87750959
30REST_21632747_ChIP-Seq_MESCs_Mouse1.87305975
31POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.86149722
32ELK3_25401928_ChIP-Seq_HUVEC_Human1.84582501
33SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.83704383
34RNF2_27304074_Chip-Seq_NSC_Mouse1.77676611
35ZFP281_27345836_Chip-Seq_ESCs_Mouse1.75586808
36KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.73106943
37EZH2_18974828_ChIP-Seq_MESCs_Mouse1.71868164
38RNF2_18974828_ChIP-Seq_MESCs_Mouse1.71868164
39ESR1_15608294_ChIP-ChIP_MCF-7_Human1.70656780
40TCF3_18692474_ChIP-Seq_MEFs_Mouse1.70256686
41NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.69537524
42PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.67204572
43NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.66497053
44ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.64423340
45HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.63433645
46TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.63204266
47CLOCK_20551151_ChIP-Seq_293T_Human1.61563200
48SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.61133227
49TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.60321490
50RING1B_27294783_Chip-Seq_NPCs_Mouse1.60265608
51EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.59807452
52TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.59401801
53RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.58806759
54RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.58286987
55E2F1_17053090_ChIP-ChIP_MCF-7_Human1.57726551
56REST_18959480_ChIP-ChIP_MESCs_Mouse1.57172941
57UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.56956097
58DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.56495360
59RARB_27405468_Chip-Seq_BRAIN_Mouse1.56009390
60MYC_22102868_ChIP-Seq_BL_Human1.54413558
61IGF1R_20145208_ChIP-Seq_DFB_Human1.54357641
62EZH2_27304074_Chip-Seq_ESCs_Mouse1.52970738
63KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.52710212
64POU5F1_16518401_ChIP-PET_MESCs_Mouse1.52080294
65IRF1_19129219_ChIP-ChIP_H3396_Human1.51360463
66RNF2_27304074_Chip-Seq_ESCs_Mouse1.51204306
67P300_27058665_Chip-Seq_ZR-75-30cells_Human1.50359111
68JARID2_20064375_ChIP-Seq_MESCs_Mouse1.49860598
69CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.46887633
70CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.46566552
71TET1_21451524_ChIP-Seq_MESCs_Mouse1.46357163
72PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.45820920
73KLF4_18555785_ChIP-Seq_MESCs_Mouse1.45404874
74KDM2B_26808549_Chip-Seq_DND41_Human1.44797445
75CREB1_26743006_Chip-Seq_LNCaP_Human1.44275426
76MYC_18555785_ChIP-Seq_MESCs_Mouse1.40829229
77KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.39951830
78POU5F1_16153702_ChIP-ChIP_HESCs_Human1.39683973
79TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.39559218
80VDR_21846776_ChIP-Seq_THP-1_Human1.39362821
81ERG_21242973_ChIP-ChIP_JURKAT_Human1.39059159
82WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.37562472
83P68_20966046_ChIP-Seq_HELA_Human1.35985879
84SRY_22984422_ChIP-ChIP_TESTIS_Rat1.34973322
85TCF7_22412390_ChIP-Seq_EML_Mouse1.34463152
86STAT6_21828071_ChIP-Seq_BEAS2B_Human1.34440294
87ZFX_18555785_ChIP-Seq_MESCs_Mouse1.34314266
88SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.33758666
89JARID2_20075857_ChIP-Seq_MESCs_Mouse1.33241026
90RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.33065538
91CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.32551318
92NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.32269806
93SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.29351666
94KDM2B_26808549_Chip-Seq_K562_Human1.27755161
95RUNX1_27514584_Chip-Seq_MCF-7_Human1.27445728
96ATF3_27146783_Chip-Seq_COLON_Human1.26773153
97BMI1_23680149_ChIP-Seq_NPCS_Mouse1.26529577
98SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.26220776
99DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.25408781
100MYC_19079543_ChIP-ChIP_MESCs_Mouse1.24340118
101NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.24291260
102TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.23804836
103CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.23781309
104CTCF_27219007_Chip-Seq_Bcells_Human1.23374701
105NANOG_16518401_ChIP-PET_MESCs_Mouse1.22343698
106TP53_22127205_ChIP-Seq_IMR90_Human1.21288257
107CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.21067713
108TBX3_20139965_ChIP-Seq_ESCs_Mouse1.20063806
109TBX3_20139965_ChIP-Seq_MESCs_Mouse1.19915984
110EZH2_27294783_Chip-Seq_ESCs_Mouse1.19043079
111PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.18747061
112NANOG_18692474_ChIP-Seq_MESCs_Mouse1.18393549
113RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.18213687
114KDM2B_26808549_Chip-Seq_JURKAT_Human1.16654063
115TET1_21490601_ChIP-Seq_MESCs_Mouse1.16635481
116AR_21909140_ChIP-Seq_LNCAP_Human1.16286878
117POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.14973791
118ESR1_21235772_ChIP-Seq_MCF-7_Human1.14587675
119RING1B_27294783_Chip-Seq_ESCs_Mouse1.14427063
120SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.13180925
121SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.12470721
122OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.11822608
123SA1_27219007_Chip-Seq_ERYTHROID_Human1.11410480
124TP53_20018659_ChIP-ChIP_R1E_Mouse1.11327852
125TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.09936176
126MTF2_20144788_ChIP-Seq_MESCs_Mouse1.09328207
127SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.09143134
128DNAJC2_21179169_ChIP-ChIP_NT2_Human1.09084392
129HIF1A_21447827_ChIP-Seq_MCF-7_Human1.08933039
130KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.08912930
131POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.08040056
132XRN2_22483619_ChIP-Seq_HELA_Human1.07925619
133CDX2_20551321_ChIP-Seq_CACO-2_Human1.07862520
134SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.07209591
135NANOG_21062744_ChIP-ChIP_HESCs_Human1.06863442
136CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.06221438
137TRIM28_21343339_ChIP-Seq_HEK293_Human1.05865709
138CTCF_27219007_Chip-Seq_ERYTHROID_Human1.04573867
139KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.03540879
140EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.03233876
141ELK4_26923725_Chip-Seq_MESODERM_Mouse1.03153845
142POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.02667151
143SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.02635536
144ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.01569496
145SUZ12_27294783_Chip-Seq_ESCs_Mouse1.01427745
146DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.99821608
147STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.99524563
148ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.99295178
149SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.99235388
150NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.98880343
151SMC4_20622854_ChIP-Seq_HELA_Human0.98502474
152NANOG_18555785_ChIP-Seq_MESCs_Mouse0.97970537
153STAT3_1855785_ChIP-Seq_MESCs_Mouse0.97841783
154STAT3_18555785_ChIP-Seq_MESCs_Mouse0.97497288
155SOX3_22085726_ChIP-Seq_NPCs_Mouse0.94049071
156EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.94013916
157SOX2_16153702_ChIP-ChIP_HESCs_Human0.93056518
158SOX2_18692474_ChIP-Seq_MESCs_Mouse0.92687747
159MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.92446621
160TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.92392768
161NANOG_16153702_ChIP-ChIP_HESCs_Human0.90299425
162SOX2_18555785_ChIP-Seq_MESCs_Mouse0.90245732
163SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.89540252
164KDM2B_26808549_Chip-Seq_SUP-B15_Human0.89172197
165GATA1_26923725_Chip-Seq_HPCs_Mouse0.88754795
166GBX2_23144817_ChIP-Seq_PC3_Human0.88475559
167HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.88005097
168CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.87392205
169SMAD3_21741376_ChIP-Seq_HESCs_Human0.87107125
170EED_16625203_ChIP-ChIP_MESCs_Mouse0.85380583
171P53_22127205_ChIP-Seq_FIBROBLAST_Human0.85369625

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode4.34070466
2MP0003122_maternal_imprinting3.84193900
3MP0004858_abnormal_nervous_system3.57794751
4MP0005394_taste/olfaction_phenotype3.25192541
5MP0005499_abnormal_olfactory_system3.25192541
6MP0003890_abnormal_embryonic-extraembry3.24550391
7MP0010234_abnormal_vibrissa_follicle3.17907531
8MP0000537_abnormal_urethra_morphology3.06377733
9MP0004264_abnormal_extraembryonic_tissu2.93787945
10MP0003011_delayed_dark_adaptation2.81579083
11MP0000566_synostosis2.68871551
12MP0003121_genomic_imprinting2.66493623
13MP0004859_abnormal_synaptic_plasticity2.45650701
14MP0002254_reproductive_system_inflammat2.39565310
15MP0002653_abnormal_ependyma_morphology2.33216027
16MP0005076_abnormal_cell_differentiation2.29253069
17MP0000579_abnormal_nail_morphology2.13720958
18MP0004270_analgesia2.06547364
19MP0003123_paternal_imprinting2.03880782
20MP0000678_abnormal_parathyroid_gland2.00063571
21MP0003787_abnormal_imprinting1.98524121
22MP0002249_abnormal_larynx_morphology1.94808897
23MP0003880_abnormal_central_pattern1.90815778
24MP0005075_abnormal_melanosome_morpholog1.86780800
25MP0008961_abnormal_basal_metabolism1.84813846
26MP0003635_abnormal_synaptic_transmissio1.82543301
27MP0005409_darkened_coat_color1.79856830
28MP0004233_abnormal_muscle_weight1.79220089
29MP0009046_muscle_twitch1.78645865
30MP0003938_abnormal_ear_development1.77902448
31MP0002697_abnormal_eye_size1.74402570
32MP0002332_abnormal_exercise_endurance1.74209273
33MP0005257_abnormal_intraocular_pressure1.73005437
34MP0002877_abnormal_melanocyte_morpholog1.71443371
35MP0002572_abnormal_emotion/affect_behav1.67908095
36MP0002063_abnormal_learning/memory/cond1.64354334
37MP0004272_abnormal_basement_membrane1.64239227
38MP0002909_abnormal_adrenal_gland1.63745758
39MP0004185_abnormal_adipocyte_glucose1.63121933
40MP0005423_abnormal_somatic_nervous1.62767639
41MP0001486_abnormal_startle_reflex1.59906307
42MP0003183_abnormal_peptide_metabolism1.58575544
43MP0003329_amyloid_beta_deposits1.57613120
44MP0008057_abnormal_DNA_replication1.57162047
45MP0003283_abnormal_digestive_organ1.55588481
46MP0003566_abnormal_cell_adhesion1.53510609
47MP0002734_abnormal_mechanical_nocicepti1.49974973
48MP0005058_abnormal_lysosome_morphology1.49364965
49MP0009672_abnormal_birth_weight1.49308075
50MP0004043_abnormal_pH_regulation1.47707840
51MP0002184_abnormal_innervation1.41455385
52MP0008789_abnormal_olfactory_epithelium1.40431272
53MP0000462_abnormal_digestive_system1.40327662
54MP0006035_abnormal_mitochondrial_morpho1.39844704
55MP0000778_abnormal_nervous_system1.39152597
56MP0009780_abnormal_chondrocyte_physiolo1.38957709
57MP0003453_abnormal_keratinocyte_physiol1.38298135
58MP0003119_abnormal_digestive_system1.37305935
59MP0009053_abnormal_anal_canal1.36334245
60MP0009379_abnormal_foot_pigmentation1.35071028
61MP0005451_abnormal_body_composition1.34994644
62MP0001730_embryonic_growth_arrest1.34733242
63MP0002089_abnormal_postnatal_growth/wei1.33237329
64MP0002064_seizures1.32665064
65MP0002796_impaired_skin_barrier1.31684018
66MP0001293_anophthalmia1.30649009
67MP0000049_abnormal_middle_ear1.29305374
68MP0000955_abnormal_spinal_cord1.29295337
69MP0002127_abnormal_cardiovascular_syste1.28061570
70MP0000631_abnormal_neuroendocrine_gland1.27961220
71MP0003941_abnormal_skin_development1.27504597
72MP0002733_abnormal_thermal_nociception1.24731161
73MP0009745_abnormal_behavioral_response1.24323316
74MP0002233_abnormal_nose_morphology1.22779980
75MP0005248_abnormal_Harderian_gland1.22513938
76MP0000534_abnormal_ureter_morphology1.21675178
77MP0005501_abnormal_skin_physiology1.21540539
78MP0003115_abnormal_respiratory_system1.20253665
79MP0000467_abnormal_esophagus_morphology1.19655817
80MP0002932_abnormal_joint_morphology1.19451494
81MP0003137_abnormal_impulse_conducting1.18345681
82MP0010030_abnormal_orbit_morphology1.16716801
83MP0000762_abnormal_tongue_morphology1.13409287
84MP0002277_abnormal_respiratory_mucosa1.11249666
85MP0000751_myopathy1.10999468
86MP0002098_abnormal_vibrissa_morphology1.10557609
87MP0008932_abnormal_embryonic_tissue1.09494519
88MP0003111_abnormal_nucleus_morphology1.09376929
89MP0005380_embryogenesis_phenotype1.08734091
90MP0001672_abnormal_embryogenesis/_devel1.08734091
91MP0003937_abnormal_limbs/digits/tail_de1.08680555
92MP0002272_abnormal_nervous_system1.08493289
93MP0001849_ear_inflammation1.08422235
94MP0002751_abnormal_autonomic_nervous1.06828511
95MP0005666_abnormal_adipose_tissue1.06723827
96MP0004957_abnormal_blastocyst_morpholog1.06696615
97MP0003861_abnormal_nervous_system1.06030016
98MP0000003_abnormal_adipose_tissue1.05987974
99MP0005623_abnormal_meninges_morphology1.05596968
100MP0002114_abnormal_axial_skeleton1.05351172
101MP0001501_abnormal_sleep_pattern1.03002195
102MP0003634_abnormal_glial_cell1.01895365
103MP0003755_abnormal_palate_morphology1.01237627
104MP0002060_abnormal_skin_morphology0.99226057
105MP0003935_abnormal_craniofacial_develop0.98713856
106MP0000733_abnormal_muscle_development0.97501464
107MP0002557_abnormal_social/conspecific_i0.97366113
108MP0002111_abnormal_tail_morphology0.97309184
109MP0002088_abnormal_embryonic_growth/wei0.97191430
110MP0010630_abnormal_cardiac_muscle0.97112670
111MP0001970_abnormal_pain_threshold0.96731543
112MP0004133_heterotaxia0.96689755
113MP0005253_abnormal_eye_physiology0.96331676
114MP0003385_abnormal_body_wall0.96189766
115MP0002752_abnormal_somatic_nervous0.96169832
116MP0002882_abnormal_neuron_morphology0.95311679
117MP0001299_abnormal_eye_distance/0.94832553
118MP0000428_abnormal_craniofacial_morphol0.93905940
119MP0001346_abnormal_lacrimal_gland0.93765686
120MP0003984_embryonic_growth_retardation0.93761813
121MP0002067_abnormal_sensory_capabilities0.93552410
122MP0009384_cardiac_valve_regurgitation0.93518173
123MP0002116_abnormal_craniofacial_bone0.93484812
124MP0004811_abnormal_neuron_physiology0.92948584
125MP0002092_abnormal_eye_morphology0.92585066
126MP0001348_abnormal_lacrimal_gland0.92108053
127MP0002080_prenatal_lethality0.91279065
128MP0004197_abnormal_fetal_growth/weight/0.90640436
129MP0002081_perinatal_lethality0.89413070
130MP0005375_adipose_tissue_phenotype0.88980439
131MP0005391_vision/eye_phenotype0.88515396
132MP0001440_abnormal_grooming_behavior0.88128721
133MP0002085_abnormal_embryonic_tissue0.87763653
134MP0003705_abnormal_hypodermis_morpholog0.87748422
135MP0000747_muscle_weakness0.87048005
136MP0006276_abnormal_autonomic_nervous0.86435934
137MP0002084_abnormal_developmental_patter0.85165538
138MP0000377_abnormal_hair_follicle0.85013707
139MP0002152_abnormal_brain_morphology0.82862927
140MP0003315_abnormal_perineum_morphology0.82841330
141MP0004782_abnormal_surfactant_physiolog0.81730131
142MP0001968_abnormal_touch/_nociception0.81114700
143MP0008770_decreased_survivor_rate0.80964727
144MP0002896_abnormal_bone_mineralization0.80205700
145MP0010678_abnormal_skin_adnexa0.80122007
146MP0006072_abnormal_retinal_apoptosis0.78688256
147MP0001697_abnormal_embryo_size0.78490737
148MP0009840_abnormal_foam_cell0.78308152
149MP0008438_abnormal_cutaneous_collagen0.77910009
150MP0004087_abnormal_muscle_fiber0.77703598
151MP0004142_abnormal_muscle_tone0.77434913
152MP0002086_abnormal_extraembryonic_tissu0.76788583
153MP0004085_abnormal_heartbeat0.76632866
154MP0003693_abnormal_embryo_hatching0.76315727
155MP0003091_abnormal_cell_migration0.76233713
156MP0000432_abnormal_head_morphology0.75932844
157MP0001340_abnormal_eyelid_morphology0.75434983
158MP0005551_abnormal_eye_electrophysiolog0.73071062
159MP0010352_gastrointestinal_tract_polyps0.69666628
160MP0004885_abnormal_endolymph0.66978066
161MP0003942_abnormal_urinary_system0.65647958
162MP0009703_decreased_birth_body0.64953258

Predicted human phenotypes

RankGene SetZ-score
1Bilateral microphthalmos (HP:0007633)6.38996538
2Hepatoblastoma (HP:0002884)5.54067624
3Abnormality of the lower motor neuron (HP:0002366)5.11484357
4Hypochromic microcytic anemia (HP:0004840)4.56207709
5Hyperacusis (HP:0010780)4.09468475
6Rib fusion (HP:0000902)3.80252859
7Amyotrophic lateral sclerosis (HP:0007354)3.79293808
8Ependymoma (HP:0002888)3.60854726
9Hyperventilation (HP:0002883)3.55940560
10Nephroblastoma (Wilms tumor) (HP:0002667)3.24892765
11Aplasia/Hypoplasia of the fovea (HP:0008060)3.22997191
12Hypoplasia of the fovea (HP:0007750)3.22997191
13Multiple enchondromatosis (HP:0005701)3.17758939
14Neoplasm of striated muscle (HP:0009728)3.14732738
15Bifid tongue (HP:0010297)3.11307640
16Epileptic encephalopathy (HP:0200134)3.05353616
17Astrocytoma (HP:0009592)3.03596291
18Abnormality of the astrocytes (HP:0100707)3.03596291
19Embryonal renal neoplasm (HP:0011794)3.03345237
20Ulnar bowing (HP:0003031)2.99003729
21Horizontal nystagmus (HP:0000666)2.94232287
22Febrile seizures (HP:0002373)2.91711341
23Insomnia (HP:0100785)2.83502878
24Amblyopia (HP:0000646)2.82263751
25Neoplasm of the heart (HP:0100544)2.80993706
26Turricephaly (HP:0000262)2.78061615
27Partial duplication of thumb phalanx (HP:0009944)2.77865300
28Rhabdomyosarcoma (HP:0002859)2.66173242
29Shallow orbits (HP:0000586)2.65915363
30Hyperinsulinemic hypoglycemia (HP:0000825)2.62723657
31Generalized hypotonia (HP:0001290)2.62693726
32Renal duplication (HP:0000075)2.60601145
33Abnormality of the phalanges of the hallux (HP:0010057)2.59024850
34Abnormality of the fovea (HP:0000493)2.54994033
35Shawl scrotum (HP:0000049)2.52769613
36Rectovaginal fistula (HP:0000143)2.51863083
37Rectal fistula (HP:0100590)2.51863083
38Hemiparesis (HP:0001269)2.48139956
39Anomalous pulmonary venous return (HP:0010772)2.47955769
40Elfin facies (HP:0004428)2.44436299
41Partial duplication of the phalanx of hand (HP:0009999)2.43435646
42Aplasia involving bones of the extremities (HP:0009825)2.42971169
43Aplasia involving bones of the upper limbs (HP:0009823)2.42971169
44Aplasia of the phalanges of the hand (HP:0009802)2.42971169
45Overriding aorta (HP:0002623)2.42657518
46Bronchomalacia (HP:0002780)2.40833158
47Testicular atrophy (HP:0000029)2.37673688
48Abnormality of the salivary glands (HP:0010286)2.36797877
49Upper limb amyotrophy (HP:0009129)2.36297159
50Distal upper limb amyotrophy (HP:0007149)2.36297159
51Fused cervical vertebrae (HP:0002949)2.35708455
52Periauricular skin pits (HP:0100277)2.35574629
53Preauricular pit (HP:0004467)2.35574629
54Flat acetabular roof (HP:0003180)2.34847837
55Abnormality of chromosome segregation (HP:0002916)2.33894159
56Broad face (HP:0000283)2.33815752
57Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.32731054
58Focal seizures (HP:0007359)2.32015090
59Asymmetry of the thorax (HP:0001555)2.31988565
60Short humerus (HP:0005792)2.30491392
61Chromosomal breakage induced by crosslinking agents (HP:0003221)2.28984857
62Intestinal fistula (HP:0100819)2.28869304
63Pendular nystagmus (HP:0012043)2.26046702
64Aplasia/hypoplasia of the humerus (HP:0006507)2.24040830
65Glioma (HP:0009733)2.23508592
66Achilles tendon contracture (HP:0001771)2.20801865
67Distal lower limb amyotrophy (HP:0008944)2.20706141
68Cerebral aneurysm (HP:0004944)2.19847745
69Obstructive sleep apnea (HP:0002870)2.18963870
70Protrusio acetabuli (HP:0003179)2.18379692
71Atonic seizures (HP:0010819)2.15114367
72Pterygium (HP:0001059)2.14205577
73Vertebral arch anomaly (HP:0008438)2.14141472
74Malignant neoplasm of the central nervous system (HP:0100836)2.12784776
75Tetraplegia (HP:0002445)2.12250500
76Cerebral inclusion bodies (HP:0100314)2.11514050
77Dialeptic seizures (HP:0011146)2.10359022
78Abnormality of the distal phalanx of the thumb (HP:0009617)2.10052530
79Short nail (HP:0001799)2.09768821
80Abnormality of the Achilles tendon (HP:0005109)2.07381927
81Difficulty running (HP:0009046)2.06823928
82Abnormality of the pubic bones (HP:0003172)2.06577749
83Abnormality of the pulmonary veins (HP:0011718)2.06213155
84Mitral regurgitation (HP:0001653)2.05798943
85Abnormal lung lobation (HP:0002101)2.05662596
86Lower limb amyotrophy (HP:0007210)2.05646102
87Pointed chin (HP:0000307)2.05624315
88Hypopigmentation of the fundus (HP:0007894)2.05393325
89Arnold-Chiari malformation (HP:0002308)2.04989706
90Renovascular hypertension (HP:0100817)2.04826140
91Ragged-red muscle fibers (HP:0003200)2.04500218
92Premature rupture of membranes (HP:0001788)2.04494775
93Aplasia/Hypoplasia of the macula (HP:0008059)2.03594118
94Vaginal fistula (HP:0004320)2.02509932
95Nasolacrimal duct obstruction (HP:0000579)2.01809078
96Resting tremor (HP:0002322)2.01473181
97Truncus arteriosus (HP:0001660)2.01092502
98Neurofibrillary tangles (HP:0002185)2.00799643
99Focal motor seizures (HP:0011153)1.99995005
100Patellar dislocation (HP:0002999)1.99443938
101Drooling (HP:0002307)1.97646817
102Excessive salivation (HP:0003781)1.97646817
103Atrophy/Degeneration involving motor neurons (HP:0007373)1.97126890
104Broad distal phalanx of finger (HP:0009836)1.96379610
105Visual hallucinations (HP:0002367)1.96045410
106Aplasia/Hypoplasia affecting the retina (HP:0008061)1.95452662
107Skin pits (HP:0100276)1.94619238
108Preauricular skin tag (HP:0000384)1.94386151
109Supernumerary nipples (HP:0002558)1.90891354
110Aplasia/Hypoplasia of the sternum (HP:0006714)1.90749839
111Abnormality of the corticospinal tract (HP:0002492)1.90255250
112Abnormality of the aortic arch (HP:0012303)1.89742591
113Large earlobe (HP:0009748)1.88910947
114Abnormality of the calcaneus (HP:0008364)1.88827436
115Disproportionate tall stature (HP:0001519)1.88734533
116Advanced eruption of teeth (HP:0006288)1.87938256
117Abnormality of the musculature of the hand (HP:0001421)1.87206682
118Open mouth (HP:0000194)1.87008623
119Supernumerary spleens (HP:0009799)1.87003951
120Failure to thrive in infancy (HP:0001531)1.86235106
121Precocious puberty (HP:0000826)1.86097402
122Missing ribs (HP:0000921)1.85553295
123Embryonal neoplasm (HP:0002898)1.85234910
124Dysmetric saccades (HP:0000641)1.83374839
125Macroorchidism (HP:0000053)1.83303826
126J-shaped sella turcica (HP:0002680)1.82182638
127Dyschromatopsia (HP:0007641)1.81930366
128Fragile skin (HP:0001030)1.81044507
129Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.80079736
130Selective tooth agenesis (HP:0001592)1.80011005
131Facial cleft (HP:0002006)1.79961298
132Sensory axonal neuropathy (HP:0003390)1.79930485
133Hypoplasia of the capital femoral epiphysis (HP:0003090)1.79581828
134Ankyloglossia (HP:0010296)1.79305141
135Abnormal ventriculo-arterial connection (HP:0011563)1.78966090
136Transposition of the great arteries (HP:0001669)1.78966090
137Abnormal connection of the cardiac segments (HP:0011545)1.78966090
138Germ cell neoplasia (HP:0100728)1.78937487
139Long palpebral fissure (HP:0000637)1.78415974
140Nervous tissue neoplasm (HP:0030060)1.78215535
141Neuroectodermal neoplasm (HP:0030061)1.78215535
142Neuroepithelial neoplasm (HP:0030063)1.78215535
143Stridor (HP:0010307)1.77713526
144Skin tags (HP:0010609)1.76810840
145Spinal cord compression (HP:0002176)1.76472498
146Hand muscle atrophy (HP:0009130)1.76464076
147Coronal craniosynostosis (HP:0004440)1.76160621
148Increased nuchal translucency (HP:0010880)1.75413727
149Impulsivity (HP:0100710)1.75389446
150Abnormality of the thoracic spine (HP:0100711)1.75235172
151Back pain (HP:0003418)1.74777142
152Abnormality of the lacrimal duct (HP:0011481)1.73459150
153Hyperparathyroidism (HP:0000843)1.72612038
154Chromsome breakage (HP:0040012)1.72524302
155Spastic tetraparesis (HP:0001285)1.71250393
156Bowed forearm bones (HP:0003956)1.71052872
157Bowing of the arm (HP:0006488)1.71052872
158Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.70994803
159Absent epiphyses (HP:0010577)1.70994803
160Natal tooth (HP:0000695)1.70207874
161Ectopic anus (HP:0004397)1.70141628
162Right ventricular cardiomyopathy (HP:0011663)1.69737104
163Duplication of thumb phalanx (HP:0009942)1.68448329
164Hypercalcemia (HP:0003072)1.67723514
165High anterior hairline (HP:0009890)1.67503014
166Increased connective tissue (HP:0009025)1.66696994
167Short 5th finger (HP:0009237)1.66432004
168Preaxial foot polydactyly (HP:0001841)1.65808568
169Deep venous thrombosis (HP:0002625)1.64998581
170Choanal stenosis (HP:0000452)1.64876532
171Abnormality of the distal phalanges of the toes (HP:0010182)1.63475781
172Hyperthyroidism (HP:0000836)1.62552884
173Flat cornea (HP:0007720)1.62103630
174Hammertoe (HP:0001765)1.61788492
175Spinal rigidity (HP:0003306)1.60067145
176Centrally nucleated skeletal muscle fibers (HP:0003687)1.59255260
177Congenital glaucoma (HP:0001087)1.56660008
178Bladder diverticulum (HP:0000015)1.54327880
179Midface retrusion (HP:0011800)1.53507185
180Thin bony cortex (HP:0002753)1.53317461
181Difficulty climbing stairs (HP:0003551)1.53050512
182Thin ribs (HP:0000883)1.52815026
183Atrophic scars (HP:0001075)1.52542905
184Bowel incontinence (HP:0002607)1.52462893
185Abnormal ossification of hand bones (HP:0005921)1.52072630
186Cervical subluxation (HP:0003308)1.51475043
187Abnormality of carpal bone ossification (HP:0006257)1.51193629
188Biconcave vertebral bodies (HP:0004586)1.50093903
189Abnormality of dentin (HP:0010299)1.49377639
190Vertebral compression fractures (HP:0002953)1.48580972
191Broad thumb (HP:0011304)1.47418508
192Urethral obstruction (HP:0000796)1.47265374

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK126.71430290
2GRK55.31312880
3TRIB34.83209408
4EEF2K3.49997331
5GRK63.25820451
6SMG13.12575213
7SIK12.89179550
8ADRBK22.82900315
9TYRO32.82340435
10ERN12.80077614
11GRK12.58915745
12MARK12.47406532
13MAP3K92.39269612
14MST1R2.31651086
15IRAK32.23244701
16GRK72.20050953
17NTRK12.14857916
18MAPK72.12698673
19PKN22.10407713
20WNK12.06875309
21NTRK32.06074304
22CSF1R1.94979430
23MAP2K41.85107131
24MATK1.80496413
25TTN1.78821671
26MARK21.71086486
27TTK1.68038388
28TGFBR21.63028313
29NTRK21.60275505
30LATS21.57521204
31MOS1.55824460
32CAMK41.52790451
33MET1.51738035
34NME21.51210897
35EPHB21.45946380
36SIK21.39947518
37FGFR41.38352403
38EPHA41.35577274
39CAMK1D1.34867306
40ARAF1.26271436
41AKT31.23305079
42CAMK1G1.21294488
43PAK61.20834839
44HIPK21.19984988
45ADRBK11.19171410
46MAP3K41.18419660
47LMTK21.11731582
48PTK61.11470892
49RPS6KA21.06786060
50STK381.02257870
51ALK1.01379970
52MINK10.97914313
53CHEK20.94494150
54DMPK0.94260512
55PRKD30.93960439
56PRKG20.93448612
57LATS10.92290807
58DAPK20.92023179
59EPHA20.91738892
60CDK70.90579037
61DYRK1A0.88658553
62ERBB40.87847087
63RPS6KB20.85050516
64PAK40.84650821
65MAP2K60.84469637
66BRAF0.82365573
67BMX0.78815549
68IRAK20.77824815
69SCYL20.72617110
70MAPK120.72408749
71PRKCG0.71614806
72CDK190.67645860
73PRPF4B0.67603191
74WNK30.66056644
75FGFR30.65169875
76CDK50.63417570
77UHMK10.63304657
78MAP2K20.63227431
79STK100.62524701
80MAP3K70.62340534
81AKT20.62237681
82TESK10.61449587
83CASK0.61114178
84DYRK20.59037772
85MAP2K70.59010269
86MAP3K80.58975459
87CDK150.58300674
88PLK10.58174676
89MAPK130.57382330
90PAK30.56699915
91CDK180.56257810
92CHEK10.55929497
93RPS6KL10.55657869
94RPS6KC10.55657869
95CAMK2B0.55523749
96CAMK2G0.55145743
97AURKA0.54547331
98PAK20.53379775
99BRSK10.52662996
100KSR10.52662773
101CDK11A0.52200765
102ICK0.52134231
103ILK0.52008149
104PRKD20.52002839
105RPS6KA10.50313942
106PHKG20.48729098
107PHKG10.48729098
108FGFR20.48222265
109CDK140.47619134
110PDGFRA0.47481243
111RET0.45609153
112MAPK100.44972130
113KSR20.44966956
114PDPK10.44544462
115CAMK10.44466194
116CSNK1E0.42501237
117ERBB20.42063718
118LRRK20.41807129
119EPHB10.41339020
120PRKCI0.41077934
121CAMK2D0.40014660
122TAOK10.39714544
123DAPK10.38749363
124DDR20.38630859
125MAP3K20.38207904
126GSK3B0.37760398
127PDK40.37644929
128PDK30.37644929
129CDK20.37592501
130PTK20.37291858
131MAP3K110.36835832
132MTOR0.36163283
133PRKAA10.35900259
134RIPK10.34987979
135ROCK20.34013665
136RPS6KA30.33964812
137DYRK1B0.33703336
138RPS6KA60.33488259
139SGK30.33447791
140MAP3K60.33212192
141MAP3K100.32271138
142TNK20.31235454
143TNIK0.28698960
144CDC42BPA0.27998261
145IGF1R0.27811087
146STK110.26539434
147CDK10.26295694
148CDC70.25329917
149MAPK140.25209426
150PRKACB0.25160512
151CAMKK10.23791702

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006034.48358694
2Vitamin B6 metabolism_Homo sapiens_hsa007503.70985702
3Nicotine addiction_Homo sapiens_hsa050332.49277553
4Fructose and mannose metabolism_Homo sapiens_hsa000512.31619285
5GABAergic synapse_Homo sapiens_hsa047272.28966614
6Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.19411778
7Synaptic vesicle cycle_Homo sapiens_hsa047212.10436224
8Glutamatergic synapse_Homo sapiens_hsa047242.10049509
9Notch signaling pathway_Homo sapiens_hsa043302.03983886
10Taste transduction_Homo sapiens_hsa047421.90779345
11Long-term potentiation_Homo sapiens_hsa047201.87410066
12Biosynthesis of amino acids_Homo sapiens_hsa012301.75863927
13Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.66284417
14Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.62906528
15mTOR signaling pathway_Homo sapiens_hsa041501.62485776
16Serotonergic synapse_Homo sapiens_hsa047261.62278232
17Circadian entrainment_Homo sapiens_hsa047131.54781130
18Bladder cancer_Homo sapiens_hsa052191.53719185
19Long-term depression_Homo sapiens_hsa047301.52895951
20Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.50254850
21Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.49291925
22Adherens junction_Homo sapiens_hsa045201.48472676
23Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.46226610
24Insulin secretion_Homo sapiens_hsa049111.45456144
25Morphine addiction_Homo sapiens_hsa050321.45019710
26Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.44233760
27Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.42956227
28Dopaminergic synapse_Homo sapiens_hsa047281.42906869
29Chronic myeloid leukemia_Homo sapiens_hsa052201.36884594
30Pentose phosphate pathway_Homo sapiens_hsa000301.35800345
31Galactose metabolism_Homo sapiens_hsa000521.33806594
32Prion diseases_Homo sapiens_hsa050201.33452938
33Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.29849851
342-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.27383012
35Phosphatidylinositol signaling system_Homo sapiens_hsa040701.26574493
36Phospholipase D signaling pathway_Homo sapiens_hsa040721.26194640
37Hedgehog signaling pathway_Homo sapiens_hsa043401.25705294
38Amphetamine addiction_Homo sapiens_hsa050311.25441668
39Sulfur relay system_Homo sapiens_hsa041221.25377343
40Salivary secretion_Homo sapiens_hsa049701.24874264
41Insulin signaling pathway_Homo sapiens_hsa049101.24671249
42GnRH signaling pathway_Homo sapiens_hsa049121.23993149
43Other glycan degradation_Homo sapiens_hsa005111.22208838
44Calcium signaling pathway_Homo sapiens_hsa040201.20645587
45Oxytocin signaling pathway_Homo sapiens_hsa049211.17713846
46Arachidonic acid metabolism_Homo sapiens_hsa005901.17293945
47Axon guidance_Homo sapiens_hsa043601.16496388
48Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.15478827
49Renin secretion_Homo sapiens_hsa049241.15311132
50Inositol phosphate metabolism_Homo sapiens_hsa005621.15228572
51ECM-receptor interaction_Homo sapiens_hsa045121.15190621
52Olfactory transduction_Homo sapiens_hsa047401.15134747
53Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.14420405
54Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.11450689
55Arginine biosynthesis_Homo sapiens_hsa002201.09752635
56Basal cell carcinoma_Homo sapiens_hsa052171.08901308
57Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.07947291
58Lysine degradation_Homo sapiens_hsa003101.07793503
59cAMP signaling pathway_Homo sapiens_hsa040241.06370305
60Ovarian steroidogenesis_Homo sapiens_hsa049131.05618664
61Focal adhesion_Homo sapiens_hsa045101.05200020
62Linoleic acid metabolism_Homo sapiens_hsa005911.04760902
63Cyanoamino acid metabolism_Homo sapiens_hsa004601.04692334
64Carbon metabolism_Homo sapiens_hsa012001.04306224
65Thyroid hormone signaling pathway_Homo sapiens_hsa049191.03918762
66Wnt signaling pathway_Homo sapiens_hsa043101.03722165
67Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.03550960
68Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.03411871
69Choline metabolism in cancer_Homo sapiens_hsa052311.03205503
70Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.02699652
71Thyroid cancer_Homo sapiens_hsa052161.02020780
72mRNA surveillance pathway_Homo sapiens_hsa030151.01496578
73Gap junction_Homo sapiens_hsa045401.01391048
74Proteoglycans in cancer_Homo sapiens_hsa052051.00800407
75Cholinergic synapse_Homo sapiens_hsa047250.99150379
76alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.98072118
77Vibrio cholerae infection_Homo sapiens_hsa051100.96891631
78Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.96521222
79Aldosterone synthesis and secretion_Homo sapiens_hsa049250.94191603
80Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.93990574
81Cocaine addiction_Homo sapiens_hsa050300.91320264
82Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.91294202
83Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.90561308
84Rap1 signaling pathway_Homo sapiens_hsa040150.89068151
85ErbB signaling pathway_Homo sapiens_hsa040120.88849004
86Oocyte meiosis_Homo sapiens_hsa041140.88177932
87Hippo signaling pathway_Homo sapiens_hsa043900.88114901
88Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.87929947
89Melanogenesis_Homo sapiens_hsa049160.87817031
90DNA replication_Homo sapiens_hsa030300.86773881
91Thyroid hormone synthesis_Homo sapiens_hsa049180.85611147
92Vascular smooth muscle contraction_Homo sapiens_hsa042700.85069226
93Small cell lung cancer_Homo sapiens_hsa052220.84150839
94Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.81877023
95Dorso-ventral axis formation_Homo sapiens_hsa043200.81224716
96Pancreatic cancer_Homo sapiens_hsa052120.80812259
97Glucagon signaling pathway_Homo sapiens_hsa049220.80756022
98Gastric acid secretion_Homo sapiens_hsa049710.79948306
99Estrogen signaling pathway_Homo sapiens_hsa049150.78484256
100Bile secretion_Homo sapiens_hsa049760.78306552
101Central carbon metabolism in cancer_Homo sapiens_hsa052300.77516494
102Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.77092214
103Type II diabetes mellitus_Homo sapiens_hsa049300.76470251
104Dilated cardiomyopathy_Homo sapiens_hsa054140.76438186
105Ras signaling pathway_Homo sapiens_hsa040140.74982282
106Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.74527031
107Arginine and proline metabolism_Homo sapiens_hsa003300.73146741
108Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.72545217
109Glioma_Homo sapiens_hsa052140.72103083
110Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.70744249
111cGMP-PKG signaling pathway_Homo sapiens_hsa040220.69875151
112Non-small cell lung cancer_Homo sapiens_hsa052230.68465225
113Regulation of actin cytoskeleton_Homo sapiens_hsa048100.67773691
114Prostate cancer_Homo sapiens_hsa052150.67750976
115MAPK signaling pathway_Homo sapiens_hsa040100.67258598
116Cell cycle_Homo sapiens_hsa041100.66706169
117Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.65767135
118Phototransduction_Homo sapiens_hsa047440.65431349
119Endometrial cancer_Homo sapiens_hsa052130.65317544
120VEGF signaling pathway_Homo sapiens_hsa043700.63846449
121Tight junction_Homo sapiens_hsa045300.61412578
122Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.60893473
123Longevity regulating pathway - mammal_Homo sapiens_hsa042110.60564363
124Cardiac muscle contraction_Homo sapiens_hsa042600.59773556
125Pathways in cancer_Homo sapiens_hsa052000.59486069
126Folate biosynthesis_Homo sapiens_hsa007900.58814097
127Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.58306409
128Neurotrophin signaling pathway_Homo sapiens_hsa047220.58155620
129Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.57765873
130Phenylalanine metabolism_Homo sapiens_hsa003600.57402701
131Colorectal cancer_Homo sapiens_hsa052100.57362947
132Sphingolipid signaling pathway_Homo sapiens_hsa040710.55659640
133Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.55618697
134Melanoma_Homo sapiens_hsa052180.55268797
135AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.54944694
136Pyruvate metabolism_Homo sapiens_hsa006200.54485502
137Glycerophospholipid metabolism_Homo sapiens_hsa005640.53940401
138Ether lipid metabolism_Homo sapiens_hsa005650.52984918
139AMPK signaling pathway_Homo sapiens_hsa041520.52605104
140Fatty acid biosynthesis_Homo sapiens_hsa000610.52582587
141Adipocytokine signaling pathway_Homo sapiens_hsa049200.51518521
142Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.50957822
143N-Glycan biosynthesis_Homo sapiens_hsa005100.50761174
144RNA transport_Homo sapiens_hsa030130.48624012
145Insulin resistance_Homo sapiens_hsa049310.48585360
146African trypanosomiasis_Homo sapiens_hsa051430.48067910
147Glycosaminoglycan degradation_Homo sapiens_hsa005310.43485718
148Renal cell carcinoma_Homo sapiens_hsa052110.43122607
149Collecting duct acid secretion_Homo sapiens_hsa049660.42540599
150Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.41923168
151Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.41776009
152MicroRNAs in cancer_Homo sapiens_hsa052060.39922842

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