PPP1R26P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1meiotic chromosome segregation (GO:0045132)5.38522640
2cellular response to ATP (GO:0071318)4.72006779
3V(D)J recombination (GO:0033151)4.67125536
4negative regulation of cell aging (GO:0090344)4.52683952
5mature B cell differentiation involved in immune response (GO:0002313)4.38254020
6cellular response to ethanol (GO:0071361)4.26315322
7G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)4.25288847
8monoubiquitinated protein deubiquitination (GO:0035520)4.15837142
9response to peptidoglycan (GO:0032494)4.11350938
10purinergic nucleotide receptor signaling pathway (GO:0035590)4.09514876
11response to muramyl dipeptide (GO:0032495)4.07957913
12mature B cell differentiation (GO:0002335)3.86647165
13urinary tract smooth muscle contraction (GO:0014848)3.83908067
14positive thymic T cell selection (GO:0045059)3.81851082
15positive T cell selection (GO:0043368)3.81565481
16immunoglobulin mediated immune response (GO:0016064)3.67729432
17corticosteroid receptor signaling pathway (GO:0031958)3.65010367
18negative regulation of granulocyte differentiation (GO:0030853)3.64772174
19peptidyl-lysine methylation (GO:0018022)3.60173710
20snRNA transcription (GO:0009301)3.51910125
21histone H3-K36 demethylation (GO:0070544)3.50824112
22pericardium development (GO:0060039)3.50541242
23positive regulation of granulocyte differentiation (GO:0030854)3.46054903
24negative regulation of thymocyte apoptotic process (GO:0070244)3.45437281
25replicative senescence (GO:0090399)3.40840501
26histone H3-K4 trimethylation (GO:0080182)3.33457844
27negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.32067433
28negative regulation of translation, ncRNA-mediated (GO:0040033)3.32067433
29regulation of translation, ncRNA-mediated (GO:0045974)3.32067433
30T cell lineage commitment (GO:0002360)3.26379589
31adenosine receptor signaling pathway (GO:0001973)3.22251055
32response to pheromone (GO:0019236)3.20606051
33lens fiber cell differentiation (GO:0070306)3.15888170
34regulation of T-helper 2 cell differentiation (GO:0045628)3.11741577
35regulation of skeletal muscle contraction (GO:0014819)3.10519933
36regulation of B cell receptor signaling pathway (GO:0050855)3.09607899
37regulation of granulocyte differentiation (GO:0030852)3.08754542
38cellular response to exogenous dsRNA (GO:0071360)3.08025995
39cardiolipin metabolic process (GO:0032048)3.06864827
40regulation of thymocyte apoptotic process (GO:0070243)3.06487855
41negative regulation of TOR signaling (GO:0032007)3.03291712
42regulation of establishment of cell polarity (GO:2000114)3.03122091
43positive regulation of developmental pigmentation (GO:0048087)3.01651215
44B cell receptor signaling pathway (GO:0050853)2.98390565
45granulocyte differentiation (GO:0030851)2.98175522
46histone H3-K9 demethylation (GO:0033169)2.97339212
47phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.96393600
48negative regulation of Rho protein signal transduction (GO:0035024)2.95316856
49peptidyl-lysine trimethylation (GO:0018023)2.94147318
50negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)2.94048350
51response to ATP (GO:0033198)2.93382149
52keratinocyte development (GO:0003334)2.92684306
53glucocorticoid receptor signaling pathway (GO:0042921)2.87217572
54negative thymic T cell selection (GO:0045060)2.87095192
55positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.84845871
56purinergic receptor signaling pathway (GO:0035587)2.79870749
57negative T cell selection (GO:0043383)2.79244226
58detection of molecule of bacterial origin (GO:0032490)2.78845524
59histone phosphorylation (GO:0016572)2.78805497
60embryonic process involved in female pregnancy (GO:0060136)2.78653136
61negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.77750787
62negative regulation of T-helper cell differentiation (GO:0045623)2.77750787
63T cell selection (GO:0045058)2.74741888
64atrioventricular valve morphogenesis (GO:0003181)2.74699214
65myeloid cell activation involved in immune response (GO:0002275)2.73913766
66histone demethylation (GO:0016577)2.72727187
67growth hormone receptor signaling pathway (GO:0060396)2.72131311
68regulation of T-helper 1 cell differentiation (GO:0045625)2.70906499
69regulation of histone H3-K9 methylation (GO:0051570)2.70436877
70positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.68434584
71regulation of hypersensitivity (GO:0002883)2.68392457
72negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.67011956
73mast cell activation involved in immune response (GO:0002279)2.65928954
74mast cell degranulation (GO:0043303)2.65928954
75positive regulation of mast cell activation (GO:0033005)2.65036577
76positive regulation of T-helper cell differentiation (GO:0045624)2.64857584
77positive regulation of protein kinase C signaling (GO:0090037)2.64392575
78interkinetic nuclear migration (GO:0022027)2.64278123
79B cell mediated immunity (GO:0019724)2.63777985
80positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.61890338
81histone lysine demethylation (GO:0070076)2.61103467
82sex determination (GO:0007530)2.60657887
83protein K48-linked deubiquitination (GO:0071108)2.54565813
84mast cell activation (GO:0045576)2.54321887
85mannose metabolic process (GO:0006013)2.52066371
86GDP-mannose metabolic process (GO:0019673)2.51981446
87histone H3-K9 methylation (GO:0051567)2.51619340
88mRNA cleavage (GO:0006379)2.51083371
89DNA strand renaturation (GO:0000733)2.49848702
90regulation of interleukin-12 biosynthetic process (GO:0045075)2.49196219
91hypotonic response (GO:0006971)2.48638420
92cellular extravasation (GO:0045123)2.46324680
93multicellular organismal movement (GO:0050879)2.45730849
94musculoskeletal movement (GO:0050881)2.45730849
95histone H3-K4 methylation (GO:0051568)2.45106951
96positive regulation of B cell proliferation (GO:0030890)2.44994254
97cellular response to growth hormone stimulus (GO:0071378)2.44422642
98protein import into peroxisome matrix (GO:0016558)2.43787856
99cytoplasmic mRNA processing body assembly (GO:0033962)2.42795108
100regulation of B cell proliferation (GO:0030888)2.42724154

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse4.92475797
2VDR_21846776_ChIP-Seq_THP-1_Human4.59509512
3STAT6_21828071_ChIP-Seq_BEAS2B_Human4.00398549
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.37516162
5VDR_24763502_ChIP-Seq_THP-1_Human3.32805867
6IRF8_22096565_ChIP-ChIP_GC-B_Human3.24986023
7MYC_22102868_ChIP-Seq_BL_Human3.11215116
8FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.99207865
9SCL_19346495_ChIP-Seq_HPC-7_Human2.75514760
10TP63_19390658_ChIP-ChIP_HaCaT_Human2.74616723
11MAF_26560356_Chip-Seq_TH1_Human2.71504199
12MAF_26560356_Chip-Seq_TH2_Human2.57768885
13E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.43254240
14TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.36195813
15MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.25223730
16KDM2B_26808549_Chip-Seq_SUP-B15_Human2.24436351
17SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.21929704
18CIITA_25753668_ChIP-Seq_RAJI_Human2.19070094
19TCF7_22412390_ChIP-Seq_EML_Mouse2.18844173
20UTX_26944678_Chip-Seq_JUKART_Human2.13642004
21KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.92706644
22PKCTHETA_26484144_Chip-Seq_BREAST_Human1.92001456
23RUNX_20019798_ChIP-Seq_JUKART_Human1.82261315
24KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.81612979
25P68_20966046_ChIP-Seq_HELA_Human1.80900245
26VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.79310195
27KDM2B_26808549_Chip-Seq_DND41_Human1.79183181
28MYB_26560356_Chip-Seq_TH1_Human1.78654149
29SMAD_19615063_ChIP-ChIP_OVARY_Human1.76411243
30BCOR_27268052_Chip-Seq_Bcells_Human1.73072377
31BCL6_27268052_Chip-Seq_Bcells_Human1.70554016
32CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.67419197
33IRF8_27001747_Chip-Seq_BMDM_Mouse1.65931877
34DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.65688569
35BRD4_27068464_Chip-Seq_AML-cells_Mouse1.60576490
36GATA1_22025678_ChIP-Seq_K562_Human1.58701657
37NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.55735974
38MYB_26560356_Chip-Seq_TH2_Human1.51376384
39GATA3_27048872_Chip-Seq_THYMUS_Human1.42457549
40PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.42160565
41GATA1_19941827_ChIP-Seq_MEL_Mouse1.41651811
42NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.41111416
43KDM2B_26808549_Chip-Seq_JURKAT_Human1.40833654
44SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.40511118
45EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.39392352
46PHF8_20622854_ChIP-Seq_HELA_Human1.38410561
47RUNX1_22412390_ChIP-Seq_EML_Mouse1.36946575
48FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.35212291
49SPI1_23127762_ChIP-Seq_K562_Human1.34399872
50SPI1_23547873_ChIP-Seq_NB4_Human1.33602667
51NOTCH1_21737748_ChIP-Seq_TLL_Human1.32645266
52FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.31175490
53E2F1_20622854_ChIP-Seq_HELA_Human1.31072102
54IRF8_21731497_ChIP-ChIP_J774_Mouse1.29673623
55IKZF1_21737484_ChIP-ChIP_HCT116_Human1.25885878
56VDR_24787735_ChIP-Seq_THP-1_Human1.24681590
57MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.23579255
58PU.1_20513432_ChIP-Seq_Bcells_Mouse1.21341109
59GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.20889989
60GATA1_19941826_ChIP-Seq_K562_Human1.20763257
61VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.19716278
62FOXM1_23109430_ChIP-Seq_U2OS_Human1.19271676
63LXR_22292898_ChIP-Seq_THP-1_Human1.18051969
64MYB_21317192_ChIP-Seq_ERMYB_Mouse1.17321035
65STAT4_19710469_ChIP-ChIP_TH1__Mouse1.17196083
66NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.16833510
67CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.16224681
68RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.15603407
69SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.13902797
70CTCF_21964334_ChIP-Seq_BJAB-B_Human1.13696760
71GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.11814920
72MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.11253324
73UBF1/2_26484160_Chip-Seq_HMECs_Human1.09801734
74ELF1_20517297_ChIP-Seq_JURKAT_Human1.08732394
75PU_27001747_Chip-Seq_BMDM_Mouse1.08546778
76TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.07335235
77SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.07236426
78P300_27268052_Chip-Seq_Bcells_Human1.06871920
79CTCF_21964334_Chip-Seq_Bcells_Human1.05838913
80RARG_19884340_ChIP-ChIP_MEFs_Mouse1.03087890
81DROSHA_22980978_ChIP-Seq_HELA_Human1.02964873
82TAF15_26573619_Chip-Seq_HEK293_Human1.02740415
83PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.02627962
84TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.01406059
85STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.01377049
86CTCF_27219007_Chip-Seq_ERYTHROID_Human1.00216074
87ELK3_25401928_ChIP-Seq_HUVEC_Human0.99470533
88SALL1_21062744_ChIP-ChIP_HESCs_Human0.97439689
89SMC4_20622854_ChIP-Seq_HELA_Human0.96991213
90ERA_21632823_ChIP-Seq_H3396_Human0.96965345
91GATA1_19941827_ChIP-Seq_MEL86_Mouse0.93748881
92BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.92333300
93SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.89733558
94RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.89501153
95OCT4_19829295_ChIP-Seq_ESCs_Human0.88431726
96RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87470480
97PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.87188036
98Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.86834941
99CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.86263356
100IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.85730534

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005174_abnormal_tail_pigmentation4.70106258
2MP0003646_muscle_fatigue3.68551108
3MP0001986_abnormal_taste_sensitivity3.57815578
4MP0000569_abnormal_digit_pigmentation3.48489360
5MP0005171_absent_coat_pigmentation3.21699807
6MP0009278_abnormal_bone_marrow3.08861725
7MP0000015_abnormal_ear_pigmentation3.02472027
8MP0001835_abnormal_antigen_presentation2.74202435
9MP0005397_hematopoietic_system_phenotyp2.49298779
10MP0001545_abnormal_hematopoietic_system2.49298779
11MP0004130_abnormal_muscle_cell2.44909173
12MP0005423_abnormal_somatic_nervous2.36931999
13MP0005409_darkened_coat_color2.31488474
14MP0004381_abnormal_hair_follicle2.29026663
15MP0000685_abnormal_immune_system2.25855728
16MP0005671_abnormal_response_to2.17234692
17MP0002009_preneoplasia2.15113165
18MP0004185_abnormal_adipocyte_glucose2.14609927
19MP0002876_abnormal_thyroid_physiology2.13164526
20MP0002132_abnormal_respiratory_system2.12095222
21MP0001800_abnormal_humoral_immune2.04096434
22MP0002166_altered_tumor_susceptibility2.03249633
23MP0002396_abnormal_hematopoietic_system1.97165549
24MP0008057_abnormal_DNA_replication1.96264015
25MP0005076_abnormal_cell_differentiation1.90882084
26MP0003763_abnormal_thymus_physiology1.84568605
27MP0002837_dystrophic_cardiac_calcinosis1.80381253
28MP0001853_heart_inflammation1.79717592
29MP0004808_abnormal_hematopoietic_stem1.73762178
30MP0003136_yellow_coat_color1.72136007
31MP0008961_abnormal_basal_metabolism1.59507683
32MP0002398_abnormal_bone_marrow1.48698530
33MP0004947_skin_inflammation1.46815242
34MP0003172_abnormal_lysosome_physiology1.44781450
35MP0002452_abnormal_antigen_presenting1.42710777
36MP0001790_abnormal_immune_system1.42561455
37MP0005387_immune_system_phenotype1.42561455
38MP0005666_abnormal_adipose_tissue1.38598567
39MP0003828_pulmonary_edema1.34779592
40MP0003436_decreased_susceptibility_to1.34136549
41MP0002723_abnormal_immune_serum1.34063927
42MP0002405_respiratory_system_inflammati1.33746550
43MP0001188_hyperpigmentation1.32342332
44MP0010094_abnormal_chromosome_stability1.31687734
45MP0002933_joint_inflammation1.31270417
46MP0003303_peritoneal_inflammation1.22333264
47MP0002419_abnormal_innate_immunity1.22010512
48MP0000716_abnormal_immune_system1.19785714
49MP0001756_abnormal_urination1.19040468
50MP0005000_abnormal_immune_tolerance1.17366636
51MP0002420_abnormal_adaptive_immunity1.16304644
52MP0003091_abnormal_cell_migration1.16145202
53MP0001819_abnormal_immune_cell1.15432714
54MP0002095_abnormal_skin_pigmentation1.13947832
55MP0000703_abnormal_thymus_morphology1.12480728
56MP0002722_abnormal_immune_system1.11470672
57MP0000689_abnormal_spleen_morphology1.09400241
58MP0002006_tumorigenesis1.09008663
59MP0002638_abnormal_pupillary_reflex1.07079953
60MP0003111_abnormal_nucleus_morphology1.04729219
61MP0010155_abnormal_intestine_physiology1.04001534
62MP0002429_abnormal_blood_cell1.02364009
63MP0005083_abnormal_biliary_tract1.01082150
64MP0001661_extended_life_span1.00660994
65MP0005375_adipose_tissue_phenotype1.00583002
66MP0005025_abnormal_response_to0.99321378
67MP0009115_abnormal_fat_cell0.99301703
68MP0002019_abnormal_tumor_incidence0.99206713
69MP0009785_altered_susceptibility_to0.99058124
70MP0002998_abnormal_bone_remodeling0.98192140
71MP0002148_abnormal_hypersensitivity_rea0.96365391
72MP0002075_abnormal_coat/hair_pigmentati0.93854547
73MP0000371_diluted_coat_color0.92063444
74MP0005451_abnormal_body_composition0.87132440
75MP0005410_abnormal_fertilization0.85600581
76MP0005647_abnormal_sex_gland0.83626028
77MP0001502_abnormal_circadian_rhythm0.82663345
78MP0005464_abnormal_platelet_physiology0.82657579
79MP0005334_abnormal_fat_pad0.81440860
80MP0001879_abnormal_lymphatic_vessel0.79438767
81MP0001191_abnormal_skin_condition0.79210631
82MP0004233_abnormal_muscle_weight0.75328072
83MP0004043_abnormal_pH_regulation0.71118019
84MP0000427_abnormal_hair_cycle0.70071849
85MP0003705_abnormal_hypodermis_morpholog0.69412778
86MP0003453_abnormal_keratinocyte_physiol0.68026565
87MP0000003_abnormal_adipose_tissue0.67714861
88MP0000367_abnormal_coat/_hair0.66484601
89MP0001873_stomach_inflammation0.66086219
90MP0000470_abnormal_stomach_morphology0.65969945
91MP0010386_abnormal_urinary_bladder0.62466485
92MP0000013_abnormal_adipose_tissue0.62425760
93MP0005367_renal/urinary_system_phenotyp0.62418823
94MP0000516_abnormal_urinary_system0.62418823
95MP0008775_abnormal_heart_ventricle0.62116407
96MP0009764_decreased_sensitivity_to0.61783821
97MP0003724_increased_susceptibility_to0.61433448
98MP0003077_abnormal_cell_cycle0.60689504
99MP0010307_abnormal_tumor_latency0.57294372
100MP0001765_abnormal_ion_homeostasis0.57184692

Predicted human phenotypes

RankGene SetZ-score
1Hypoplasia of the thymus (HP:0000778)5.68833007
2Panhypogammaglobulinemia (HP:0003139)5.55793101
3B lymphocytopenia (HP:0010976)5.50136578
4Abnormality of B cell number (HP:0010975)5.06242605
5Intestinal fistula (HP:0100819)4.71109309
6Thyroiditis (HP:0100646)4.46717853
7Rectal fistula (HP:0100590)4.21079064
8Rectovaginal fistula (HP:0000143)4.21079064
9Severe combined immunodeficiency (HP:0004430)4.14814988
10Aplasia of the musculature (HP:0100854)3.95292509
11T lymphocytopenia (HP:0005403)3.77943350
12Poikiloderma (HP:0001029)3.72609467
13Hypoproteinemia (HP:0003075)3.65677027
14Vaginal fistula (HP:0004320)3.54409202
15Combined immunodeficiency (HP:0005387)3.36870192
16Rib fusion (HP:0000902)3.30687459
17Spinal cord lesions (HP:0100561)3.22857723
18Syringomyelia (HP:0003396)3.22857723
19Abnormality of T cell number (HP:0011839)3.17598910
20Recurrent fungal infections (HP:0002841)3.11429170
21Attenuation of retinal blood vessels (HP:0007843)3.08624839
22Eosinophilia (HP:0001880)3.08131954
23Thin bony cortex (HP:0002753)3.07096405
24Abnormality of the nasal septum (HP:0000419)3.06721561
25Recurrent viral infections (HP:0004429)2.95847598
26Patellar aplasia (HP:0006443)2.94299718
27Facial hemangioma (HP:0000329)2.84759180
28Aplasia/Hypoplasia involving the musculature (HP:0001460)2.81476126
29Lip pit (HP:0100267)2.80014346
30Congenital stationary night blindness (HP:0007642)2.79529252
31Increased number of teeth (HP:0011069)2.78524064
32Genetic anticipation (HP:0003743)2.75394623
33Dyschromatopsia (HP:0007641)2.75279172
34Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.72908330
35Abnormality of the columella (HP:0009929)2.71517990
36Granulocytopenia (HP:0001913)2.66094520
37Abnormality of the fingertips (HP:0001211)2.65660446
38Aplasia/Hypoplasia of the patella (HP:0006498)2.64962385
39Breast hypoplasia (HP:0003187)2.61237853
40Annular pancreas (HP:0001734)2.60053299
41Squamous cell carcinoma (HP:0002860)2.53890129
42Increased neuronal autofluorescent lipopigment (HP:0002074)2.53556666
43Abnormality of eosinophils (HP:0001879)2.50496004
44Birth length less than 3rd percentile (HP:0003561)2.46286869
45Recurrent cutaneous fungal infections (HP:0011370)2.45727655
46Chronic mucocutaneous candidiasis (HP:0002728)2.45727655
47Hypoplastic nipples (HP:0002557)2.44773954
48Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.44657185
49Flat occiput (HP:0005469)2.43450164
50Abnormality of the costochondral junction (HP:0000919)2.40987846
51Capillary hemangiomas (HP:0005306)2.39415740
52Abnormality of DNA repair (HP:0003254)2.38065200
53Premature graying of hair (HP:0002216)2.35608866
54Enlarged epiphyses (HP:0010580)2.33160936
55Anteriorly placed anus (HP:0001545)2.31519050
56Ulnar bowing (HP:0003031)2.27421876
57Sparse lateral eyebrow (HP:0005338)2.24185823
58Protruding tongue (HP:0010808)2.23324476
59Abnormality of the hepatic vasculature (HP:0006707)2.22543371
60Abnormality of the pons (HP:0007361)2.22436459
61Short chin (HP:0000331)2.20930202
62Colitis (HP:0002583)2.15623918
63Fair hair (HP:0002286)2.15153338
64Clumsiness (HP:0002312)2.14520096
65Meningitis (HP:0001287)2.12666935
66Increased cerebral lipofuscin (HP:0011813)2.12621703
67Hypoplasia of the pons (HP:0012110)2.12565142
68Agammaglobulinemia (HP:0004432)2.07615468
69Short humerus (HP:0005792)2.07459705
70Gastrointestinal infarctions (HP:0005244)2.06081884
71Hypoplastic iliac wings (HP:0002866)2.05052425
72Decreased circulating renin level (HP:0003351)2.03629113
73Absent radius (HP:0003974)2.00875405
74Global brain atrophy (HP:0002283)1.99462306
75Facial diplegia (HP:0001349)1.98337635
76Neonatal respiratory distress (HP:0002643)1.97337086
77Leukocytosis (HP:0001974)1.97110511
78IgG deficiency (HP:0004315)1.96527361
79Dislocated radial head (HP:0003083)1.95921720
80Basal cell carcinoma (HP:0002671)1.92375636
81Absent speech (HP:0001344)1.91995173
82Prominent nose (HP:0000448)1.91156286
83Acute lymphatic leukemia (HP:0006721)1.89977214
84Aplasia/Hypoplasia of the thymus (HP:0010515)1.89829265
85Choroideremia (HP:0001139)1.89432922
86Long clavicles (HP:0000890)1.88017807
87Absent forearm bone (HP:0003953)1.87731976
88Aplasia involving forearm bones (HP:0009822)1.87731976
89Epistaxis (HP:0000421)1.85258194
90Abnormality of T cells (HP:0002843)1.85119929
91Spondylolisthesis (HP:0003302)1.84480499
92Bony spicule pigmentary retinopathy (HP:0007737)1.83930842
93Aplasia/hypoplasia of the humerus (HP:0006507)1.83489275
94Duplicated collecting system (HP:0000081)1.82917420
95Aplasia cutis congenita (HP:0001057)1.79873314
96Abnormality of the radial head (HP:0003995)1.79801150
97Abnormality of the intrinsic pathway (HP:0010989)1.79533969
98Testicular atrophy (HP:0000029)1.79105201
99Delayed epiphyseal ossification (HP:0002663)1.77714538
100Hemorrhage of the eye (HP:0011885)1.77582152

Predicted kinase interactions (KEA)

RankGene SetZ-score
1AKT36.37262615
2FRK3.59094479
3BLK3.27028305
4CDK123.24360921
5MAPK153.21889786
6ACVR1B3.01459139
7PIK3CG2.88292956
8MAP2K32.13440880
9TLK11.89815106
10BMPR1B1.82250251
11RIPK41.79848972
12BRD41.73220910
13BTK1.55271189
14ZAP701.54099668
15MAP4K11.50299658
16MELK1.47852663
17ZAK1.46287274
18MARK21.39215203
19WNK41.32027488
20MAP3K101.30371180
21GRK61.27012383
22NLK1.25550761
23CDK61.20776435
24PRKD21.20206339
25CDK81.20035585
26MAP3K71.15535893
27TRPM71.14614851
28MAPK111.14394525
29SYK1.09120676
30CDK41.06956630
31BMPR21.06517120
32MAP3K61.04590447
33TGFBR21.04355722
34CAMK1G1.02687050
35IKBKB1.01042804
36CSF1R0.99061365
37MAP3K130.96782675
38RPS6KA60.94073122
39CAMK1D0.93515961
40HIPK20.92084053
41JAK30.89814625
42SIK20.88527561
43RPS6KL10.87500147
44RPS6KC10.87500147
45TAOK30.86852240
46KIT0.86298483
47PIM10.85375080
48TEC0.84573403
49LYN0.83742666
50HCK0.83620552
51ICK0.83144567
52ITK0.81759132
53STK110.80917068
54MAP2K20.79810691
55WNK10.79610723
56PDPK10.77648515
57TGFBR10.77475945
58TRIB30.75703411
59PDK10.74741229
60MTOR0.71364701
61FES0.71209091
62MAPK120.71078293
63ERN10.69758660
64LCK0.69213988
65PIM20.68586863
66SGK20.65673680
67CSK0.64511978
68RPS6KA20.64319354
69DYRK1B0.64041800
70CDK190.63181059
71ADRBK10.62647035
72MKNK20.62475504
73TYK20.61988593
74MARK30.61132682
75EIF2AK30.59791486
76MAPK70.59104364
77SIK10.58550015
78NEK90.56956019
79MAP3K140.56437009
80IKBKE0.54748988
81JAK20.53498592
82FGFR30.53304622
83CHUK0.52964172
84SGK4940.52284182
85SGK2230.52284182
86PRKD10.50901198
87MAPK80.50720568
88TXK0.50490442
89MAP2K40.50381949
90SGK30.50367606
91MET0.48707243
92SGK10.45025832
93PRKAA10.44527610
94RPS6KB10.44239256
95OXSR10.43965206
96GRK70.43517935
97RAF10.42970569
98ATR0.42021045
99MAP2K60.41648704
100PDGFRB0.39330929

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006043.89782059
2Asthma_Homo sapiens_hsa053103.12018211
3Intestinal immune network for IgA production_Homo sapiens_hsa046722.57635989
4Graft-versus-host disease_Homo sapiens_hsa053322.43963679
5Allograft rejection_Homo sapiens_hsa053302.43837010
6Sulfur relay system_Homo sapiens_hsa041222.38094728
7Autoimmune thyroid disease_Homo sapiens_hsa053202.34764783
8Systemic lupus erythematosus_Homo sapiens_hsa053222.31496291
9Primary immunodeficiency_Homo sapiens_hsa053402.15286679
10Leishmaniasis_Homo sapiens_hsa051401.94400221
11Staphylococcus aureus infection_Homo sapiens_hsa051501.92319461
12Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.80908977
13Type I diabetes mellitus_Homo sapiens_hsa049401.68482536
14B cell receptor signaling pathway_Homo sapiens_hsa046621.57236502
15Viral myocarditis_Homo sapiens_hsa054161.54493070
16Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.54348189
17Hematopoietic cell lineage_Homo sapiens_hsa046401.51182393
18Tuberculosis_Homo sapiens_hsa051521.47622344
19Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.45517164
20Toxoplasmosis_Homo sapiens_hsa051451.42910369
21Type II diabetes mellitus_Homo sapiens_hsa049301.39404524
22mTOR signaling pathway_Homo sapiens_hsa041501.35928998
23Influenza A_Homo sapiens_hsa051641.35301324
24FoxO signaling pathway_Homo sapiens_hsa040681.34913295
25Fanconi anemia pathway_Homo sapiens_hsa034601.34869461
26Glycosaminoglycan degradation_Homo sapiens_hsa005311.31979571
27NOD-like receptor signaling pathway_Homo sapiens_hsa046211.28553827
28Antigen processing and presentation_Homo sapiens_hsa046121.22699866
29Acute myeloid leukemia_Homo sapiens_hsa052211.21544987
30Dorso-ventral axis formation_Homo sapiens_hsa043201.21515343
31Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.18937275
32Lysine degradation_Homo sapiens_hsa003101.11832631
33Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.08191797
34Non-small cell lung cancer_Homo sapiens_hsa052231.07364830
35Osteoclast differentiation_Homo sapiens_hsa043801.06617686
36Herpes simplex infection_Homo sapiens_hsa051681.06519328
37Alcoholism_Homo sapiens_hsa050341.05711836
38Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.05688090
39Toll-like receptor signaling pathway_Homo sapiens_hsa046201.05461264
40Non-homologous end-joining_Homo sapiens_hsa034501.04261052
41Inositol phosphate metabolism_Homo sapiens_hsa005621.03718690
42NF-kappa B signaling pathway_Homo sapiens_hsa040641.03664103
43Phosphatidylinositol signaling system_Homo sapiens_hsa040701.02063948
44Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.01910039
45Jak-STAT signaling pathway_Homo sapiens_hsa046301.00836102
46Transcriptional misregulation in cancer_Homo sapiens_hsa052021.00108265
47Chronic myeloid leukemia_Homo sapiens_hsa052200.93954178
48Homologous recombination_Homo sapiens_hsa034400.93392107
49Circadian rhythm_Homo sapiens_hsa047100.93223736
50T cell receptor signaling pathway_Homo sapiens_hsa046600.88009441
51HTLV-I infection_Homo sapiens_hsa051660.87535683
52Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.85680993
53Hepatitis B_Homo sapiens_hsa051610.84481678
54RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.84400521
55Carbohydrate digestion and absorption_Homo sapiens_hsa049730.81439380
56Insulin resistance_Homo sapiens_hsa049310.76454649
57Platelet activation_Homo sapiens_hsa046110.76338685
58Pancreatic cancer_Homo sapiens_hsa052120.74659208
59Viral carcinogenesis_Homo sapiens_hsa052030.74357704
60Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.74298264
61TNF signaling pathway_Homo sapiens_hsa046680.73846269
62Prolactin signaling pathway_Homo sapiens_hsa049170.73798466
63Adipocytokine signaling pathway_Homo sapiens_hsa049200.71365991
64Taste transduction_Homo sapiens_hsa047420.70178021
65Bladder cancer_Homo sapiens_hsa052190.69213292
66Rheumatoid arthritis_Homo sapiens_hsa053230.67978975
67Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.67887894
68Neurotrophin signaling pathway_Homo sapiens_hsa047220.67508232
69Colorectal cancer_Homo sapiens_hsa052100.66383166
70Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.65493160
71AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.63980125
72VEGF signaling pathway_Homo sapiens_hsa043700.61708824
73Measles_Homo sapiens_hsa051620.61330730
74Lysosome_Homo sapiens_hsa041420.57624321
75Small cell lung cancer_Homo sapiens_hsa052220.56550446
76Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.54363773
77MicroRNAs in cancer_Homo sapiens_hsa052060.53908193
78Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.52491159
79Thyroid hormone signaling pathway_Homo sapiens_hsa049190.51635789
80Fructose and mannose metabolism_Homo sapiens_hsa000510.51623337
81TGF-beta signaling pathway_Homo sapiens_hsa043500.51478194
82MAPK signaling pathway_Homo sapiens_hsa040100.51382627
83Calcium signaling pathway_Homo sapiens_hsa040200.49124966
84ErbB signaling pathway_Homo sapiens_hsa040120.47790235
85Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.47497331
86Renal cell carcinoma_Homo sapiens_hsa052110.46413950
87Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.46349238
88Longevity regulating pathway - mammal_Homo sapiens_hsa042110.45466071
89Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.45031096
90Phospholipase D signaling pathway_Homo sapiens_hsa040720.44908938
91Prostate cancer_Homo sapiens_hsa052150.44825084
92SNARE interactions in vesicular transport_Homo sapiens_hsa041300.44321037
93Chemokine signaling pathway_Homo sapiens_hsa040620.44210571
94Notch signaling pathway_Homo sapiens_hsa043300.43521436
95Hepatitis C_Homo sapiens_hsa051600.43020869
96Endometrial cancer_Homo sapiens_hsa052130.42597626
97p53 signaling pathway_Homo sapiens_hsa041150.41739016
98Apoptosis_Homo sapiens_hsa042100.41514972
99Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.40928358
100Cell cycle_Homo sapiens_hsa041100.40629047

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