PPP1R26P4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of sequestering of triglyceride (GO:0010889)6.50726977
2regulation of somitogenesis (GO:0014807)6.02966389
3homocysteine metabolic process (GO:0050667)5.82182343
4response to stimulus involved in regulation of muscle adaptation (GO:0014874)5.66934829
5regulation of plasminogen activation (GO:0010755)5.23066043
6viral mRNA export from host cell nucleus (GO:0046784)5.17083615
7regulation of skeletal muscle contraction (GO:0014819)5.11117992
8positive regulation of fatty acid oxidation (GO:0046321)5.06801167
9sarcoplasmic reticulum calcium ion transport (GO:0070296)4.91440195
10epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)4.87054951
11regulation of tight junction assembly (GO:2000810)4.82727924
12positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)4.76357826
13sarcomere organization (GO:0045214)4.74769489
14muscle filament sliding (GO:0030049)4.60889795
15actin-myosin filament sliding (GO:0033275)4.60889795
16desmosome organization (GO:0002934)4.60443124
17carnitine shuttle (GO:0006853)4.57654857
18negative regulation of DNA biosynthetic process (GO:2000279)4.46390843
19cardiac muscle contraction (GO:0060048)4.42068002
20white fat cell differentiation (GO:0050872)4.41740869
21cell migration involved in heart development (GO:0060973)4.38144556
22membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.36723917
23sulfur amino acid catabolic process (GO:0000098)4.24770086
24microtubule nucleation (GO:0007020)4.23094841
25cartilage morphogenesis (GO:0060536)4.21238150
26response to caffeine (GO:0031000)4.16640928
27regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)4.11747076
28negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)4.11524427
29fatty acid transmembrane transport (GO:1902001)4.10269335
30regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO4.06875923
31actin-mediated cell contraction (GO:0070252)4.04973394
32myofibril assembly (GO:0030239)4.02750780
33cardiac muscle hypertrophy (GO:0003300)3.98898270
34negative regulation of catenin import into nucleus (GO:0035414)3.87982588
35regulation of DNA damage checkpoint (GO:2000001)3.87933448
36adenosine metabolic process (GO:0046085)3.83781243
37striated muscle hypertrophy (GO:0014897)3.83146230
38regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.82621532
39regulation of branching involved in salivary gland morphogenesis (GO:0060693)3.80781421
40cardiac myofibril assembly (GO:0055003)3.76179673
41cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.76096032
42dendritic spine morphogenesis (GO:0060997)3.73361814
43cysteine metabolic process (GO:0006534)3.72197065
44behavioral response to nicotine (GO:0035095)3.71498033
45prostate gland growth (GO:0060736)3.70053026
46positive regulation of heart rate (GO:0010460)3.69763804
47response to epinephrine (GO:0071871)3.68252677
48tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.67952470
49RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.67952470
50striated muscle contraction (GO:0006941)3.67030920
51response to inactivity (GO:0014854)3.64503362
52galactose metabolic process (GO:0006012)3.48685012
53purine nucleotide salvage (GO:0032261)3.44979830
54regulation of fatty acid oxidation (GO:0046320)3.44636384
55regulation of actin filament-based movement (GO:1903115)3.44249726
56cardiac muscle cell action potential (GO:0086001)3.38055531
57regulation of relaxation of muscle (GO:1901077)3.37642307
58muscle hypertrophy (GO:0014896)3.36301861
59regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.35640748
60carnitine transmembrane transport (GO:1902603)3.35321024
61otic vesicle formation (GO:0030916)3.32229675
62negative regulation of Ras GTPase activity (GO:0034261)3.29902843
63regulation of energy homeostasis (GO:2000505)3.28666677
64histone H4-K12 acetylation (GO:0043983)3.28622305
65folic acid-containing compound biosynthetic process (GO:0009396)3.28309046
66positive regulation of fatty acid metabolic process (GO:0045923)3.25778426
67regulation of striated muscle contraction (GO:0006942)3.19096468
68relaxation of cardiac muscle (GO:0055119)3.16048535
69cAMP biosynthetic process (GO:0006171)3.15320153
70cardiac muscle adaptation (GO:0014887)3.14413797
71cardiac muscle hypertrophy in response to stress (GO:0014898)3.14413797
72muscle hypertrophy in response to stress (GO:0003299)3.14413797
73cardiac muscle tissue morphogenesis (GO:0055008)3.14362018
74regulation of heart rate (GO:0002027)3.13206536
75ventricular cardiac muscle cell action potential (GO:0086005)3.11908907
76actomyosin structure organization (GO:0031032)3.11160944
77regulation of vitamin D biosynthetic process (GO:0060556)3.10333799
78positive regulation of histone acetylation (GO:0035066)3.09844382
79response to muscle activity (GO:0014850)3.09728881
80adrenergic receptor signaling pathway (GO:0071875)3.06306122
81regulation of hippo signaling (GO:0035330)3.01780571
82cardiac muscle cell action potential involved in contraction (GO:0086002)3.01691681
83carnitine transport (GO:0015879)3.01082313
84amino-acid betaine transport (GO:0015838)3.01082313
85positive regulation of endothelial cell differentiation (GO:0045603)2.98448821
86regulation of membrane repolarization (GO:0060306)2.98200450
87cGMP-mediated signaling (GO:0019934)2.97657918
88cell communication by electrical coupling (GO:0010644)2.97378598
89regulation of cholesterol storage (GO:0010885)2.96372905
90cochlea development (GO:0090102)2.92265195
91muscle tissue morphogenesis (GO:0060415)2.91269648
92striated muscle adaptation (GO:0014888)2.89944249
93growth hormone secretion (GO:0030252)2.85422351
94lymphangiogenesis (GO:0001946)2.83335601
95inner ear receptor cell development (GO:0060119)2.83177877
96skeletal muscle adaptation (GO:0043501)2.82642804
97galactose catabolic process (GO:0019388)2.82574769
98creatine metabolic process (GO:0006600)2.82409845
99skeletal muscle contraction (GO:0003009)2.81781275
100primary amino compound metabolic process (GO:1901160)2.76844799

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT6_21828071_ChIP-Seq_BEAS2B_Human5.30510643
2EZH2_22144423_ChIP-Seq_EOC_Human4.95238331
3HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.16762224
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.76917452
5GBX2_23144817_ChIP-Seq_PC3_Human2.98031880
6RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.68947135
7EP300_21415370_ChIP-Seq_HL-1_Mouse2.63348983
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.50554259
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.50554259
10TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.44178562
11VDR_22108803_ChIP-Seq_LS180_Human2.29501707
12EED_16625203_ChIP-ChIP_MESCs_Mouse2.29458871
13SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.26435417
14LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse2.25938145
15CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.22221654
16EZH2_27304074_Chip-Seq_ESCs_Mouse2.13565358
17SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.04138042
18CBX2_27304074_Chip-Seq_ESCs_Mouse2.02327065
19RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.99641062
20RNF2_27304074_Chip-Seq_ESCs_Mouse1.98279223
21JARID2_20075857_ChIP-Seq_MESCs_Mouse1.94796049
22SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.91844814
23SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.84941129
24KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.77562038
25KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.77562038
26KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.77562038
27AR_21572438_ChIP-Seq_LNCaP_Human1.71392152
28JARID2_20064375_ChIP-Seq_MESCs_Mouse1.70965125
29HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.70181099
30THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.69805739
31SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.66585606
32BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.61083951
33SMAD_19615063_ChIP-ChIP_OVARY_Human1.57534577
34PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.53220122
35CTBP1_25329375_ChIP-Seq_LNCAP_Human1.52599659
36DROSHA_22980978_ChIP-Seq_HELA_Human1.50622469
37SUZ12_27294783_Chip-Seq_ESCs_Mouse1.50578950
38GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.49894986
39GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.48903748
40FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.48122301
41BMI1_23680149_ChIP-Seq_NPCS_Mouse1.46000731
42EZH2_27294783_Chip-Seq_ESCs_Mouse1.45464920
43MTF2_20144788_ChIP-Seq_MESCs_Mouse1.45369153
44RNF2_27304074_Chip-Seq_NSC_Mouse1.42709700
45RXR_22108803_ChIP-Seq_LS180_Human1.37699327
46TP53_16413492_ChIP-PET_HCT116_Human1.34264525
47SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.26980332
48TDRD3_21172665_ChIP-Seq_MCF-7_Human1.22583855
49PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.21333423
50TP53_20018659_ChIP-ChIP_R1E_Mouse1.20695594
51ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.20620213
52CDX2_22108803_ChIP-Seq_LS180_Human1.20313372
53SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.19068365
54ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.19034222
55BCAT_22108803_ChIP-Seq_LS180_Human1.18698100
56TBX20_22080862_ChIP-Seq_HEART_Mouse1.15667811
57TBX20_22328084_ChIP-Seq_HEART_Mouse1.15667811
58PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.15518732
59TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.14819092
60CDX2_19796622_ChIP-Seq_MESCs_Mouse1.11879340
61RING1B_27294783_Chip-Seq_ESCs_Mouse1.11847267
62FUS_26573619_Chip-Seq_HEK293_Human1.11033168
63OCT1_27270436_Chip-Seq_PROSTATE_Human1.09927593
64PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.09739744
65NFIB_24661679_ChIP-Seq_LUNG_Mouse1.09349402
66STAT1_20625510_ChIP-Seq_HELA_Human1.08393871
67AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.06593139
68GATA1_22025678_ChIP-Seq_K562_Human1.05895909
69TRIM28_21343339_ChIP-Seq_HEK293_Human1.05082253
70CTBP2_25329375_ChIP-Seq_LNCAP_Human1.04025633
71STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.03466404
72UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.03271696
73ESR1_20079471_ChIP-ChIP_T-47D_Human1.02327519
74EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.01895872
75MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.01833425
76NR3C1_21868756_ChIP-Seq_MCF10A_Human0.96784183
77SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.91844155
78KDM2B_26808549_Chip-Seq_REH_Human0.91740056
79SMAD4_21741376_ChIP-Seq_HESCs_Human0.91527961
80MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.91393184
81RAD21_21589869_ChIP-Seq_MESCs_Mouse0.90894998
82SMAD3_21741376_ChIP-Seq_EPCs_Human0.90350899
83STAT3_23295773_ChIP-Seq_U87_Human0.89961990
84EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.88115450
85SMAD4_21799915_ChIP-Seq_A2780_Human0.87834026
86RUNX1_26923725_Chip-Seq_HPCs_Mouse0.87403345
87RUNX2_22187159_ChIP-Seq_PCA_Human0.86967463
88TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.86145498
89CJUN_26792858_Chip-Seq_BT549_Human0.85180302
90MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.84644202
91NANOG_19829295_ChIP-Seq_ESCs_Human0.83818379
92SOX2_19829295_ChIP-Seq_ESCs_Human0.83818379
93TOP2B_26459242_ChIP-Seq_MCF-7_Human0.83530897
94SOX2_21211035_ChIP-Seq_LN229_Gbm0.83154342
95PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.81585589
96CTNNB1_20460455_ChIP-Seq_HCT116_Human0.80887337
97YY1_22570637_ChIP-Seq_MALME-3M_Human0.79910670
98ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.79877507
99ZFP57_27257070_Chip-Seq_ESCs_Mouse0.78680090
100PCGF2_27294783_Chip-Seq_ESCs_Mouse0.78603688

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000751_myopathy5.73675045
2MP0003646_muscle_fatigue5.16624129
3MP0005670_abnormal_white_adipose4.75322178
4MP0001661_extended_life_span3.90792165
5MP0000749_muscle_degeneration3.51738882
6MP0000750_abnormal_muscle_regeneration2.92786238
7MP0003705_abnormal_hypodermis_morpholog2.85823496
8MP0003183_abnormal_peptide_metabolism2.85756568
9MP0004145_abnormal_muscle_electrophysio2.67966790
10MP0004036_abnormal_muscle_relaxation2.47659207
11MP0000013_abnormal_adipose_tissue2.47124202
12MP0004084_abnormal_cardiac_muscle2.40841434
13MP0004130_abnormal_muscle_cell2.32540038
14MP0004233_abnormal_muscle_weight2.31294172
15MP0004510_myositis2.30008920
16MP0002269_muscular_atrophy2.26421342
17MP0002106_abnormal_muscle_physiology2.26012032
18MP0002837_dystrophic_cardiac_calcinosis2.23936263
19MP0000747_muscle_weakness2.23074146
20MP0000372_irregular_coat_pigmentation2.19417067
21MP0002332_abnormal_exercise_endurance2.17089529
22MP0005360_urolithiasis2.12193800
23MP0005369_muscle_phenotype2.04820268
24MP0004215_abnormal_myocardial_fiber2.01344656
25MP0002108_abnormal_muscle_morphology1.92050202
26MP0004087_abnormal_muscle_fiber1.89290208
27MP0005646_abnormal_pituitary_gland1.88010901
28MP0006138_congestive_heart_failure1.78522186
29MP0005275_abnormal_skin_tensile1.77056612
30MP0000759_abnormal_skeletal_muscle1.73895742
31MP0004484_altered_response_of1.72787643
32MP0002638_abnormal_pupillary_reflex1.72016456
33MP0005409_darkened_coat_color1.71275658
34MP0005620_abnormal_muscle_contractility1.63106637
35MP0005171_absent_coat_pigmentation1.61397161
36MP0004147_increased_porphyrin_level1.54054884
37MP0002127_abnormal_cardiovascular_syste1.51551408
38MP0005330_cardiomyopathy1.50444054
39MP0002972_abnormal_cardiac_muscle1.49349611
40MP0003137_abnormal_impulse_conducting1.44607903
41MP0008995_early_reproductive_senescence1.42228350
42MP0001986_abnormal_taste_sensitivity1.40508307
43MP0003136_yellow_coat_color1.37718205
44MP0001879_abnormal_lymphatic_vessel1.32607889
45MP0001544_abnormal_cardiovascular_syste1.30736552
46MP0005385_cardiovascular_system_phenoty1.30736552
47MP0008438_abnormal_cutaneous_collagen1.30661598
48MP0005503_abnormal_tendon_morphology1.25770468
49MP0002971_abnormal_brown_adipose1.25387994
50MP0003724_increased_susceptibility_to1.23641128
51MP0003045_fibrosis1.22657708
52MP0004185_abnormal_adipocyte_glucose1.13016209
53MP0006276_abnormal_autonomic_nervous1.11627328
54MP0000003_abnormal_adipose_tissue1.10371098
55MP0002938_white_spotting1.08801236
56MP0002163_abnormal_gland_morphology1.07193764
57MP0008775_abnormal_heart_ventricle1.03501149
58MP0010630_abnormal_cardiac_muscle1.00754588
59MP0004142_abnormal_muscle_tone0.97747900
60MP0004885_abnormal_endolymph0.93828128
61MP0000371_diluted_coat_color0.93821176
62MP0001486_abnormal_startle_reflex0.92853808
63MP0010368_abnormal_lymphatic_system0.90833926
64MP0005423_abnormal_somatic_nervous0.90787926
65MP0004085_abnormal_heartbeat0.87986510
66MP0002277_abnormal_respiratory_mucosa0.87290834
67MP0000026_abnormal_inner_ear0.84400609
68MP0002234_abnormal_pharynx_morphology0.83987181
69MP0000733_abnormal_muscle_development0.80343021
70MP0005551_abnormal_eye_electrophysiolog0.75656353
71MP0004272_abnormal_basement_membrane0.75116103
72MP0001270_distended_abdomen0.73597196
73MP0005332_abnormal_amino_acid0.73026518
74MP0002095_abnormal_skin_pigmentation0.72402342
75MP0002132_abnormal_respiratory_system0.71731310
76MP0002736_abnormal_nociception_after0.69931981
77MP0001485_abnormal_pinna_reflex0.69164160
78MP0005266_abnormal_metabolism0.65148869
79MP0000467_abnormal_esophagus_morphology0.64188816
80MP0002138_abnormal_hepatobiliary_system0.64173887
81MP0005165_increased_susceptibility_to0.64089578
82MP0009115_abnormal_fat_cell0.62293916
83MP0000163_abnormal_cartilage_morphology0.60074408
84MP0003828_pulmonary_edema0.59501962
85MP0009697_abnormal_copulation0.58920655
86MP0001963_abnormal_hearing_physiology0.57796887
87MP0002075_abnormal_coat/hair_pigmentati0.56924343
88MP0002295_abnormal_pulmonary_circulatio0.56871166
89MP0009379_abnormal_foot_pigmentation0.55983481
90MP0004043_abnormal_pH_regulation0.55649532
91MP0002249_abnormal_larynx_morphology0.55619521
92MP0002735_abnormal_chemical_nociception0.55060126
93MP0009250_abnormal_appendicular_skeleto0.55018659
94MP0002089_abnormal_postnatal_growth/wei0.54223767
95MP0000534_abnormal_ureter_morphology0.54196948
96MP0008872_abnormal_physiological_respon0.53837815
97MP0002160_abnormal_reproductive_system0.53332285
98MP0005666_abnormal_adipose_tissue0.52744636
99MP0001968_abnormal_touch/_nociception0.52731102
100MP0005375_adipose_tissue_phenotype0.51598948

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of pyruvate family amino acid metabolism (HP:0010915)5.52668576
2Abnormality of alanine metabolism (HP:0010916)5.52668576
3Hyperalaninemia (HP:0003348)5.52668576
4Muscle fiber splitting (HP:0003555)5.32208590
5Tongue fasciculations (HP:0001308)5.18621660
6Muscle fibrillation (HP:0010546)4.77576236
7Calf muscle hypertrophy (HP:0008981)4.77482485
8Congenital sensorineural hearing impairment (HP:0008527)4.61907984
9Muscle hypertrophy of the lower extremities (HP:0008968)4.52661059
10Anomalous pulmonary venous return (HP:0010772)4.52407856
11Esophageal varix (HP:0002040)4.28148914
12Hyporeflexia of lower limbs (HP:0002600)4.05074853
13Difficulty running (HP:0009046)4.02866913
14Spontaneous hematomas (HP:0007420)3.91544959
15Abnormality of the pulmonary veins (HP:0011718)3.90035707
16Abnormality of the calf musculature (HP:0001430)3.81090626
17Muscle fiber inclusion bodies (HP:0100299)3.78356691
18Myopathic facies (HP:0002058)3.69378567
19Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.66393742
20Slow saccadic eye movements (HP:0000514)3.50262539
21Nemaline bodies (HP:0003798)3.40333990
22Pigmentary retinal degeneration (HP:0001146)3.34224581
23Bundle branch block (HP:0011710)3.33636349
24Diaphragmatic weakness (HP:0009113)3.24599399
25Ventricular tachycardia (HP:0004756)3.23789092
26Sudden death (HP:0001699)3.21607708
27Syncope (HP:0001279)3.19597881
28Increased connective tissue (HP:0009025)3.14538635
29EMG: myopathic abnormalities (HP:0003458)3.14509254
30Lipoatrophy (HP:0100578)3.01686357
31Maternal diabetes (HP:0009800)3.00648410
32Hyperkalemia (HP:0002153)2.99371061
33Exercise-induced myalgia (HP:0003738)2.97861574
34Constricted visual fields (HP:0001133)2.96488223
35Distal lower limb muscle weakness (HP:0009053)2.95989002
36Oral leukoplakia (HP:0002745)2.94936612
37Type 1 muscle fiber predominance (HP:0003803)2.86458943
38Rimmed vacuoles (HP:0003805)2.84683949
39Carpal bone hypoplasia (HP:0001498)2.79722428
40Atrial fibrillation (HP:0005110)2.74947067
41Hypoalphalipoproteinemia (HP:0003233)2.67654973
42Toxemia of pregnancy (HP:0100603)2.67503129
43White forelock (HP:0002211)2.52079679
44Myelomeningocele (HP:0002475)2.47759529
45Dilated cardiomyopathy (HP:0001644)2.47360867
46Absent phalangeal crease (HP:0006109)2.47311414
47Myoglobinuria (HP:0002913)2.44001897
48Abnormality of the fetal cardiovascular system (HP:0010948)2.37581659
49Abnormal umbilical cord blood vessels (HP:0011403)2.37581659
50Single umbilical artery (HP:0001195)2.37581659
51Primary atrial arrhythmia (HP:0001692)2.34892696
52Long clavicles (HP:0000890)2.32395283
53Muscular dystrophy (HP:0003560)2.30796858
54Myocardial infarction (HP:0001658)2.29538327
55Oligomenorrhea (HP:0000876)2.26499619
56Areflexia of lower limbs (HP:0002522)2.25060180
57Abnormality of the odontoid process (HP:0003310)2.25048628
58Palpitations (HP:0001962)2.23379369
59Myotonia (HP:0002486)2.20842781
60Ventricular arrhythmia (HP:0004308)2.19667976
61Abnormal finger flexion creases (HP:0006143)2.18729626
62Supraventricular tachycardia (HP:0004755)2.17527275
63Short palpebral fissure (HP:0012745)2.16415483
64Abnormality of the renal collecting system (HP:0004742)2.15171826
65Right ventricular cardiomyopathy (HP:0011663)2.13435017
66Exercise-induced muscle cramps (HP:0003710)2.11483108
67Duplicated collecting system (HP:0000081)2.10424428
68Supraventricular arrhythmia (HP:0005115)2.09687221
69Patchy hypopigmentation of hair (HP:0011365)2.08439841
70Impaired smooth pursuit (HP:0007772)2.06288326
71Heart block (HP:0012722)2.05580125
72Atrioventricular block (HP:0001678)2.01848370
73Abnormality of the ischium (HP:0003174)2.01754145
74Abnormality of the left ventricular outflow tract (HP:0011103)1.97964088
75Subaortic stenosis (HP:0001682)1.97964088
76Ventricular fibrillation (HP:0001663)1.97712944
77Cavernous hemangioma (HP:0001048)1.97470629
78Chorioretinal atrophy (HP:0000533)1.97414496
79Paralysis (HP:0003470)1.95095596
80Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.92980343
81Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.92467151
82Short 1st metacarpal (HP:0010034)1.92467151
83Abnormality of homocysteine metabolism (HP:0010919)1.91558027
84Homocystinuria (HP:0002156)1.91558027
85Hypoplastic left heart (HP:0004383)1.88886491
86Increased variability in muscle fiber diameter (HP:0003557)1.85623457
87Abnormal atrioventricular conduction (HP:0005150)1.85332450
88Difficulty climbing stairs (HP:0003551)1.85106788
89Round ear (HP:0100830)1.82273703
90Lymphangioma (HP:0100764)1.80546797
91Fibular aplasia (HP:0002990)1.80371469
92Generalized aminoaciduria (HP:0002909)1.80270313
93EMG: neuropathic changes (HP:0003445)1.78929561
94Abnormality of serum amino acid levels (HP:0003112)1.78126477
95Reduced subcutaneous adipose tissue (HP:0003758)1.77169811
96Conjugated hyperbilirubinemia (HP:0002908)1.75674132
97Action tremor (HP:0002345)1.72224355
98Decreased subcutaneous fat (HP:0001002)1.70881913
99Fatigue (HP:0012378)1.70787747
100J-shaped sella turcica (HP:0002680)1.70694297

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BLK8.16369540
2OBSCN4.81198222
3TTN3.82827230
4PHKG23.49429694
5PHKG13.49429694
6MAP2K33.39979161
7MAP3K32.86823202
8TIE11.94912438
9MUSK1.90111816
10SGK21.79792182
11MYLK1.71365318
12EPHB21.70820050
13SGK4941.62001451
14SGK2231.62001451
15MAP3K71.60162170
16CDK91.60124057
17MAPK121.34542029
18NEK11.33049308
19DYRK1B1.32920022
20SGK31.24602494
21LATS21.24292254
22NTRK21.23831107
23JAK31.23139821
24CAMK2D1.20134958
25CCNB11.17868176
26TRPM71.12641894
27PINK11.11592841
28CAMK41.09418591
29PRKAA21.09381624
30INSRR1.08315978
31LMTK21.02057963
32MAP2K10.98342138
33MAPK150.94972564
34RPS6KB20.93144848
35PDK20.87712371
36CAMK10.85957275
37MAPK70.85843074
38FGR0.85598486
39SYK0.84974181
40LATS10.84691054
41RPS6KA60.81967991
42STK40.81662831
43AKT20.80505049
44CAMK2B0.79163227
45PRPF4B0.78420407
46CAMK2G0.77738824
47MAPK40.77636047
48MARK10.75505385
49PRKD10.74701902
50WEE10.73021853
51PRKAA10.72351182
52PAK30.71673772
53ADRBK10.67548319
54PIK3CA0.63892902
55TGFBR20.63882143
56PTK60.62331309
57RPS6KC10.61462144
58RPS6KL10.61462144
59CAMK2A0.60525878
60GRK70.59201908
61PKN10.58049475
62NEK90.57850539
63TNIK0.56815326
64FRK0.54929461
65MAP2K40.54010682
66GRK10.51966581
67BCKDK0.50889325
68SGK10.49593455
69MAP3K60.49173834
70PRKACA0.47457819
71TAOK10.46876164
72PRKG10.46087253
73INSR0.45948993
74STK110.45789135
75WNK10.45133438
76MTOR0.44688754
77JAK20.41534693
78PDGFRB0.40830949
79RIPK10.38897921
80WNK40.38383142
81AKT10.37705303
82EPHA30.37096510
83RPS6KA10.35771352
84EGFR0.34797030
85NTRK30.32956419
86CSNK1A10.32761367
87MAP3K110.32614845
88ACVR1B0.32017181
89DAPK30.30429380
90MAP2K60.29769415
91RPS6KA30.29616318
92DAPK20.29447842
93PRKG20.29352348
94MATK0.29017022
95NTRK10.28417003
96ABL20.28295417
97PIK3CG0.26919803
98UHMK10.25772656
99RPS6KB10.24269262
100DMPK0.23744605

Predicted pathways (KEGG)

RankGene SetZ-score
12-Oxocarboxylic acid metabolism_Homo sapiens_hsa012104.14931810
2Arginine biosynthesis_Homo sapiens_hsa002203.69400456
3Dilated cardiomyopathy_Homo sapiens_hsa054143.48433698
4Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054103.28096677
5Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.58973215
6Cardiac muscle contraction_Homo sapiens_hsa042602.45524805
7Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.42757599
8Selenocompound metabolism_Homo sapiens_hsa004502.39204571
9Sulfur relay system_Homo sapiens_hsa041222.12914826
10Maturity onset diabetes of the young_Homo sapiens_hsa049502.03581953
11One carbon pool by folate_Homo sapiens_hsa006701.93655426
12Morphine addiction_Homo sapiens_hsa050321.90523275
13GABAergic synapse_Homo sapiens_hsa047271.74764993
14alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.70264364
15Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.67265652
16Olfactory transduction_Homo sapiens_hsa047401.66275094
17Nicotine addiction_Homo sapiens_hsa050331.56535673
18Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.49862526
19Circadian entrainment_Homo sapiens_hsa047131.46774633
20Galactose metabolism_Homo sapiens_hsa000521.45160365
21Linoleic acid metabolism_Homo sapiens_hsa005911.39986899
22Glutamatergic synapse_Homo sapiens_hsa047241.39384189
23Collecting duct acid secretion_Homo sapiens_hsa049661.36262652
24Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.30804168
25Regulation of autophagy_Homo sapiens_hsa041401.29675758
26Cholinergic synapse_Homo sapiens_hsa047251.29003786
27ABC transporters_Homo sapiens_hsa020101.28266879
28Phenylalanine metabolism_Homo sapiens_hsa003601.24690274
29PPAR signaling pathway_Homo sapiens_hsa033201.21755455
30Arginine and proline metabolism_Homo sapiens_hsa003301.19433693
31Calcium signaling pathway_Homo sapiens_hsa040201.16027511
32Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.14021346
33Systemic lupus erythematosus_Homo sapiens_hsa053221.12312072
34Renin secretion_Homo sapiens_hsa049241.08427033
35Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.08218566
36Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.06987494
37Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.06964933
38Taste transduction_Homo sapiens_hsa047421.06263304
39Ovarian steroidogenesis_Homo sapiens_hsa049131.02685778
40Longevity regulating pathway - mammal_Homo sapiens_hsa042111.02105132
41Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.01982782
42Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.96285416
43Insulin secretion_Homo sapiens_hsa049110.95425081
44Oxidative phosphorylation_Homo sapiens_hsa001900.95403104
45Bile secretion_Homo sapiens_hsa049760.95023499
46Circadian rhythm_Homo sapiens_hsa047100.92939876
47Biosynthesis of amino acids_Homo sapiens_hsa012300.90941017
48Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.90585747
49Nitrogen metabolism_Homo sapiens_hsa009100.90416479
50Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.84330789
51ECM-receptor interaction_Homo sapiens_hsa045120.84036891
52Alcoholism_Homo sapiens_hsa050340.82753310
53Starch and sucrose metabolism_Homo sapiens_hsa005000.81124902
54Fatty acid degradation_Homo sapiens_hsa000710.80711438
55Sulfur metabolism_Homo sapiens_hsa009200.80362173
56Tryptophan metabolism_Homo sapiens_hsa003800.79695523
57Staphylococcus aureus infection_Homo sapiens_hsa051500.79210347
58Pancreatic secretion_Homo sapiens_hsa049720.77177040
59Fatty acid biosynthesis_Homo sapiens_hsa000610.77129014
60Serotonergic synapse_Homo sapiens_hsa047260.75819222
61Retinol metabolism_Homo sapiens_hsa008300.72876539
62Cysteine and methionine metabolism_Homo sapiens_hsa002700.72851650
63Parkinsons disease_Homo sapiens_hsa050120.72074540
64Vascular smooth muscle contraction_Homo sapiens_hsa042700.71961143
65Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.70879498
66cGMP-PKG signaling pathway_Homo sapiens_hsa040220.68762957
67Oxytocin signaling pathway_Homo sapiens_hsa049210.67731496
68cAMP signaling pathway_Homo sapiens_hsa040240.66857016
69Alzheimers disease_Homo sapiens_hsa050100.65951016
70Peroxisome_Homo sapiens_hsa041460.65008470
71Glucagon signaling pathway_Homo sapiens_hsa049220.63507327
72Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.62907556
73Dorso-ventral axis formation_Homo sapiens_hsa043200.62907493
74Glycerophospholipid metabolism_Homo sapiens_hsa005640.62711145
75Adipocytokine signaling pathway_Homo sapiens_hsa049200.62056558
76Fat digestion and absorption_Homo sapiens_hsa049750.60738747
77Cocaine addiction_Homo sapiens_hsa050300.58025832
78Salivary secretion_Homo sapiens_hsa049700.57834127
79Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.55508800
80Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.55124973
81Arachidonic acid metabolism_Homo sapiens_hsa005900.54248770
82Carbon metabolism_Homo sapiens_hsa012000.52909492
83GnRH signaling pathway_Homo sapiens_hsa049120.52754217
84AMPK signaling pathway_Homo sapiens_hsa041520.51571962
85Ether lipid metabolism_Homo sapiens_hsa005650.51357524
86Huntingtons disease_Homo sapiens_hsa050160.51166854
87Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.49713960
88Dopaminergic synapse_Homo sapiens_hsa047280.49174789
89Complement and coagulation cascades_Homo sapiens_hsa046100.48764823
90Insulin resistance_Homo sapiens_hsa049310.47942771
91Ribosome_Homo sapiens_hsa030100.45727116
92Vitamin digestion and absorption_Homo sapiens_hsa049770.45725349
93Fatty acid metabolism_Homo sapiens_hsa012120.45372448
94Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.44663987
95Histidine metabolism_Homo sapiens_hsa003400.42469190
96Gastric acid secretion_Homo sapiens_hsa049710.42399793
97Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.40438936
98Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.39235276
99Platelet activation_Homo sapiens_hsa046110.38698005
100Viral myocarditis_Homo sapiens_hsa054160.36658473

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