PPP1R2P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein neddylation (GO:0045116)5.96609988
2negative regulation of cardiac muscle cell apoptotic process (GO:0010667)4.44893512
3negative regulation of thymocyte apoptotic process (GO:0070244)4.32244052
4positive regulation of macrophage differentiation (GO:0045651)4.16163175
5positive regulation of endothelial cell differentiation (GO:0045603)4.14371272
6antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.10513100
7negative regulation of T cell apoptotic process (GO:0070233)4.07566352
8neutrophil activation involved in immune response (GO:0002283)4.06805202
9regulation of autophagic vacuole assembly (GO:2000785)4.04718622
10antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.75844654
11purinergic nucleotide receptor signaling pathway (GO:0035590)3.73337483
12G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.68559790
13multicellular organism reproduction (GO:0032504)3.62887423
14thrombin receptor signaling pathway (GO:0070493)3.59775271
15regulation of vacuole organization (GO:0044088)3.59465985
16regulation of platelet aggregation (GO:0090330)3.57141758
17negative regulation of homotypic cell-cell adhesion (GO:0034111)3.53834738
18regulation of hypersensitivity (GO:0002883)3.52518562
19positive regulation of catecholamine secretion (GO:0033605)3.50028219
20regulation of memory T cell differentiation (GO:0043380)3.45740240
21CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)3.38530085
22T-helper cell differentiation (GO:0042093)3.38530085
23positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.36262052
24negative regulation of macrophage derived foam cell differentiation (GO:0010745)3.33333152
25regulation of platelet activation (GO:0010543)3.32665946
26neutrophil activation (GO:0042119)3.30274812
27regulation of mast cell degranulation (GO:0043304)3.30253877
28polyamine biosynthetic process (GO:0006596)3.24733337
29adenosine receptor signaling pathway (GO:0001973)3.20488777
30antigen processing and presentation of endogenous antigen (GO:0019883)3.14354776
31positive regulation of T cell mediated cytotoxicity (GO:0001916)3.12551271
32negative regulation of heart rate (GO:0010459)3.12057579
33regulation of mast cell activation involved in immune response (GO:0033006)3.11659775
34granulocyte activation (GO:0036230)3.09483848
35negative regulation of platelet activation (GO:0010544)3.09039852
36regulation of mast cell activation (GO:0033003)3.08044164
37relaxation of smooth muscle (GO:0044557)3.07944102
38negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.06354001
39negative regulation of T-helper cell differentiation (GO:0045623)3.06354001
40positive regulation of Rho protein signal transduction (GO:0035025)3.06152364
41negative regulation of appetite (GO:0032099)3.03146203
42negative regulation of response to food (GO:0032096)3.03146203
43antigen processing and presentation via MHC class Ib (GO:0002475)3.01931160
44blood coagulation, intrinsic pathway (GO:0007597)3.00281869
45negative regulation of lymphocyte apoptotic process (GO:0070229)2.99995844
46ADP metabolic process (GO:0046031)2.97707933
47regulation of germinal center formation (GO:0002634)2.96311782
48antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.94084618
49alpha-beta T cell differentiation involved in immune response (GO:0002293)2.94059082
50alpha-beta T cell activation involved in immune response (GO:0002287)2.94059082
51T cell differentiation involved in immune response (GO:0002292)2.94059082
52mitochondrial calcium ion transport (GO:0006851)2.92930741
53male meiosis (GO:0007140)2.92397506
54positive regulation of protein homodimerization activity (GO:0090073)2.88834507
55purinergic receptor signaling pathway (GO:0035587)2.88330008
56regulation of endothelial cell differentiation (GO:0045601)2.87940632
57negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.85452729
58triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.85128206
59leukocyte migration involved in inflammatory response (GO:0002523)2.84614443
60positive regulation of T cell mediated immunity (GO:0002711)2.84461324
61positive regulation of tolerance induction (GO:0002645)2.84216020
62regulation of myeloid leukocyte mediated immunity (GO:0002886)2.84111922
63negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.81657582
64negative regulation of cell killing (GO:0031342)2.81657582
65regulation of oxidative phosphorylation (GO:0002082)2.81224234
66positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.80101953
67regulation of cilium movement (GO:0003352)2.79886046
68platelet aggregation (GO:0070527)2.78841655
69negative regulation of norepinephrine secretion (GO:0010700)2.78754715
70positive regulation of myoblast differentiation (GO:0045663)2.77886849
71negative regulation of neural precursor cell proliferation (GO:2000178)2.75601365
72positive regulation of antigen processing and presentation (GO:0002579)2.74978711
73coenzyme catabolic process (GO:0009109)2.73824612
74sleep (GO:0030431)2.72383477
75positive regulation of mast cell activation (GO:0033005)2.71784501
76CD4-positive, alpha-beta T cell activation (GO:0035710)2.69210553
77regulation of dendritic cell antigen processing and presentation (GO:0002604)2.68418643
78regulation of oxidative stress-induced neuron death (GO:1903203)2.67524615
79regulation of integrin activation (GO:0033623)2.63057255
80positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.62278806
81* regulation of phosphoprotein phosphatase activity (GO:0043666)2.59402916
82regulation of thymocyte apoptotic process (GO:0070243)2.58527774
83negative regulation of striated muscle cell apoptotic process (GO:0010664)2.58435925
84regulation of T cell mediated cytotoxicity (GO:0001914)2.58016992
85amine biosynthetic process (GO:0009309)2.57762504
86negative T cell selection (GO:0043383)2.56524357
87pyrimidine nucleoside catabolic process (GO:0046135)2.55517805
88reproduction (GO:0000003)2.54736942
89positive regulation of T cell cytokine production (GO:0002726)2.53250934
90lipoxygenase pathway (GO:0019372)2.52588717
91regulation of T-helper 1 cell differentiation (GO:0045625)2.52279762
92cellular biogenic amine biosynthetic process (GO:0042401)2.50092239
93platelet formation (GO:0030220)2.48871064
94germinal center formation (GO:0002467)2.48823900
95innate immune response in mucosa (GO:0002227)2.48821695
96regulation of macrophage differentiation (GO:0045649)2.47430950
97negative regulation of smooth muscle cell proliferation (GO:0048662)2.47065342
98regulation of alpha-beta T cell proliferation (GO:0046640)2.46165677
99negative regulation of leukocyte apoptotic process (GO:2000107)2.44472000
100positive regulation of toll-like receptor signaling pathway (GO:0034123)2.44384207

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human5.54464973
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.46002714
3HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.37370940
4IRF8_22096565_ChIP-ChIP_GC-B_Human4.09162009
5SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human3.55477468
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.50967373
7IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.44559227
8LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.88035354
9STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.79990744
10IGF1R_20145208_ChIP-Seq_DFB_Human2.72957528
11GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.57425215
12IRF8_21731497_ChIP-ChIP_J774_Mouse2.51650064
13SCL_19346495_ChIP-Seq_HPC-7_Human2.46748210
14GBX2_23144817_ChIP-Seq_PC3_Human2.43417548
15RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.33794673
16CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.29435625
17IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.04581339
18LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.96497994
19MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.96363316
20GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.94262203
21STAT4_19710469_ChIP-ChIP_TH1__Mouse1.88123972
22SPI1_23127762_ChIP-Seq_K562_Human1.87043478
23VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.84755152
24EGR1_23403033_ChIP-Seq_LIVER_Mouse1.82372707
25RUNX_20019798_ChIP-Seq_JUKART_Human1.78508665
26MYB_26560356_Chip-Seq_TH2_Human1.75250795
27IKZF1_21737484_ChIP-ChIP_HCT116_Human1.70722561
28ESR1_20079471_ChIP-ChIP_T-47D_Human1.64729518
29GATA3_26560356_Chip-Seq_TH2_Human1.62758075
30GATA1_22025678_ChIP-Seq_K562_Human1.59705157
31GATA3_27048872_Chip-Seq_THYMUS_Human1.58781112
32GATA1_19941826_ChIP-Seq_K562_Human1.52672790
33PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.50137692
34CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.41607970
35GATA2_19941826_ChIP-Seq_K562_Human1.39746558
36VDR_22108803_ChIP-Seq_LS180_Human1.38482096
37CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.33749672
38MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.33081256
39AR_21572438_ChIP-Seq_LNCaP_Human1.31802724
40ER_23166858_ChIP-Seq_MCF-7_Human1.31223999
41GATA2_21666600_ChIP-Seq_HMVEC_Human1.28945781
42GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.25633760
43ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.24955759
44VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.23704970
45SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.22164785
46IRF1_19129219_ChIP-ChIP_H3396_Human1.19037166
47FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.17901887
48SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.16928249
49NANOG_20526341_ChIP-Seq_ESCs_Human1.16923304
50STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.16563114
51GATA3_21878914_ChIP-Seq_MCF-7_Human1.15549145
52IRF8_27001747_Chip-Seq_BMDM_Mouse1.14246996
53SPI1_20517297_ChIP-Seq_HL60_Human1.13732602
54SPI1_23547873_ChIP-Seq_NB4_Human1.09948301
55Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.09423329
56SMAD_19615063_ChIP-ChIP_OVARY_Human1.08914107
57CDX2_19796622_ChIP-Seq_MESCs_Mouse1.08764502
58EZH2_22144423_ChIP-Seq_EOC_Human1.08556156
59TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.07178036
60RUNX1_22412390_ChIP-Seq_EML_Mouse1.06911594
61PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.05578908
62PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.05442420
63MYB_26560356_Chip-Seq_TH1_Human1.05358655
64NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.05102853
65UTX_26944678_Chip-Seq_JUKART_Human1.04242518
66UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.03953239
67GATA1_19941827_ChIP-Seq_MEL_Mouse1.01514048
68SALL4_22934838_ChIP-ChIP_CD34+_Human0.98260022
69EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.96903385
70TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.95764321
71TDRD3_21172665_ChIP-Seq_MCF-7_Human0.95418439
72OCT1_27270436_Chip-Seq_PROSTATE_Human0.94716544
73VDR_24787735_ChIP-Seq_THP-1_Human0.94552644
74STAT1_20625510_ChIP-Seq_HELA_Human0.94015280
75P300_19829295_ChIP-Seq_ESCs_Human0.93271136
76KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.92936720
77OCT4_20526341_ChIP-Seq_ESCs_Human0.91672172
78GATA1_22383799_ChIP-Seq_G1ME_Mouse0.91309808
79BCAT_22108803_ChIP-Seq_LS180_Human0.89473306
80E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.89291296
81ARNT_22903824_ChIP-Seq_MCF-7_Human0.88925900
82PRDM14_20953172_ChIP-Seq_ESCs_Human0.86860628
83TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.86101800
84FLI1_27457419_Chip-Seq_LIVER_Mouse0.84895411
85SMAD4_21799915_ChIP-Seq_A2780_Human0.83988150
86CBP_20019798_ChIP-Seq_JUKART_Human0.83719227
87IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.83719227
88GATA3_26560356_Chip-Seq_TH1_Human0.83498377
89TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.82294046
90PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.81640925
91P300_27268052_Chip-Seq_Bcells_Human0.81220179
92BCL6_27268052_Chip-Seq_Bcells_Human0.81171443
93ELF1_20517297_ChIP-Seq_JURKAT_Human0.80754404
94SOX2_19829295_ChIP-Seq_ESCs_Human0.79736918
95NANOG_19829295_ChIP-Seq_ESCs_Human0.79736918
96MAF_26560356_Chip-Seq_TH1_Human0.79679181
97GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.79166483
98CTBP2_25329375_ChIP-Seq_LNCAP_Human0.77819832
99SMRT_27268052_Chip-Seq_Bcells_Human0.77797219
100RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.76152422

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005464_abnormal_platelet_physiology5.27876418
2MP0008004_abnormal_stomach_pH4.98689362
3MP0000465_gastrointestinal_hemorrhage4.60562216
4MP0003724_increased_susceptibility_to4.28025701
5MP0001835_abnormal_antigen_presentation3.04408624
6MP0005671_abnormal_response_to2.83510571
7MP0005410_abnormal_fertilization2.49374505
8MP0003828_pulmonary_edema2.36726922
9MP0002138_abnormal_hepatobiliary_system2.22860173
10MP0003763_abnormal_thymus_physiology2.16747977
11MP0004381_abnormal_hair_follicle2.10864013
12MP0002132_abnormal_respiratory_system2.09702269
13MP0005000_abnormal_immune_tolerance2.01990116
14MP0003806_abnormal_nucleotide_metabolis2.01839673
15MP0003436_decreased_susceptibility_to2.01660111
16MP0001984_abnormal_olfaction1.94775283
17MP0004084_abnormal_cardiac_muscle1.92369164
18MP0005646_abnormal_pituitary_gland1.90589260
19MP0002723_abnormal_immune_serum1.77952379
20MP0000230_abnormal_systemic_arterial1.72072635
21MP0001800_abnormal_humoral_immune1.71753159
22MP0004036_abnormal_muscle_relaxation1.70203611
23MP0000685_abnormal_immune_system1.69727306
24MP0005167_abnormal_blood-brain_barrier1.69245490
25MP0002148_abnormal_hypersensitivity_rea1.66474396
26MP0002653_abnormal_ependyma_morphology1.66017656
27MP0002420_abnormal_adaptive_immunity1.62115221
28MP0001819_abnormal_immune_cell1.61828389
29MP0010155_abnormal_intestine_physiology1.61608067
30MP0005387_immune_system_phenotype1.61535172
31MP0001790_abnormal_immune_system1.61535172
32MP0002166_altered_tumor_susceptibility1.59228430
33MP0009785_altered_susceptibility_to1.57912675
34MP0002452_abnormal_antigen_presenting1.55540153
35MP0002398_abnormal_bone_marrow1.51797644
36MP0000703_abnormal_thymus_morphology1.51030041
37MP0008872_abnormal_physiological_respon1.48925744
38MP0005025_abnormal_response_to1.47523163
39MP0002419_abnormal_innate_immunity1.46690352
40MP0003879_abnormal_hair_cell1.45358077
41MP0009697_abnormal_copulation1.44918765
42MP0000343_altered_response_to1.38677001
43MP0006036_abnormal_mitochondrial_physio1.37613360
44MP0002876_abnormal_thyroid_physiology1.33726496
45MP0002405_respiratory_system_inflammati1.30917309
46MP0001849_ear_inflammation1.29033809
47MP0001905_abnormal_dopamine_level1.28408525
48MP0000716_abnormal_immune_system1.27109493
49MP0001533_abnormal_skeleton_physiology1.26611901
50MP0002722_abnormal_immune_system1.25120849
51MP0002102_abnormal_ear_morphology1.20732176
52MP0001851_eye_inflammation1.19641395
53MP0004947_skin_inflammation1.15038668
54MP0001879_abnormal_lymphatic_vessel1.14725383
55MP0000749_muscle_degeneration1.14649614
56MP0002998_abnormal_bone_remodeling1.14503313
57MP0001845_abnormal_inflammatory_respons1.14196583
58MP0009764_decreased_sensitivity_to1.12487642
59MP0002009_preneoplasia1.08510374
60MP0005058_abnormal_lysosome_morphology1.08142737
61MP0003300_gastrointestinal_ulcer1.06934998
62MP0002429_abnormal_blood_cell1.05786743
63MP0000689_abnormal_spleen_morphology1.05270434
64MP0003866_abnormal_defecation1.04704936
65MP0010368_abnormal_lymphatic_system1.03797318
66MP0001188_hyperpigmentation1.03740526
67MP0008775_abnormal_heart_ventricle1.01717708
68MP0005166_decreased_susceptibility_to1.01616715
69MP0005360_urolithiasis1.01515091
70MP0004484_altered_response_of1.01178823
71MP0001664_abnormal_digestion0.99948919
72MP0003638_abnormal_response/metabolism_0.98434179
73MP0010386_abnormal_urinary_bladder0.97179647
74MP0006276_abnormal_autonomic_nervous0.93762728
75MP0000249_abnormal_blood_vessel0.93281033
76MP0005310_abnormal_salivary_gland0.90234757
77MP0004510_myositis0.86467159
78MP0003698_abnormal_male_reproductive0.84885639
79MP0005083_abnormal_biliary_tract0.84273277
80MP0002837_dystrophic_cardiac_calcinosis0.81883752
81MP0004085_abnormal_heartbeat0.81335035
82MP0005620_abnormal_muscle_contractility0.79016978
83MP0002127_abnormal_cardiovascular_syste0.78587584
84MP0001544_abnormal_cardiovascular_syste0.77685714
85MP0005385_cardiovascular_system_phenoty0.77685714
86MP0002006_tumorigenesis0.77194212
87MP0003136_yellow_coat_color0.76271714
88MP0005647_abnormal_sex_gland0.76162675
89MP0005075_abnormal_melanosome_morpholog0.74354408
90MP0009763_increased_sensitivity_to0.73554079
91MP0001929_abnormal_gametogenesis0.72706442
92MP0003795_abnormal_bone_structure0.72185026
93MP0009333_abnormal_splenocyte_physiolog0.71399765
94MP0001919_abnormal_reproductive_system0.70238354
95MP0004215_abnormal_myocardial_fiber0.68061106
96MP0008995_early_reproductive_senescence0.67803328
97MP0009765_abnormal_xenobiotic_induced0.67552532
98MP0001501_abnormal_sleep_pattern0.66972226
99MP0001756_abnormal_urination0.65185662
100MP0003183_abnormal_peptide_metabolism0.64126705

Predicted human phenotypes

RankGene SetZ-score
1Prolonged bleeding time (HP:0003010)7.23764836
2Menorrhagia (HP:0000132)6.12701465
3Increased mean platelet volume (HP:0011877)5.53165646
4Petechiae (HP:0000967)5.45994167
5Abnormal platelet volume (HP:0011876)5.33613895
6Purpura (HP:0000979)4.98586015
7Epistaxis (HP:0000421)4.77580348
8Eosinophilia (HP:0001880)4.33817271
9Granulocytopenia (HP:0001913)3.68527550
10Abnormal ciliary motility (HP:0012262)3.52575250
11Elevated erythrocyte sedimentation rate (HP:0003565)3.51702723
12Abnormality of eosinophils (HP:0001879)3.34014411
13Gingival bleeding (HP:0000225)3.31433335
14Ventricular fibrillation (HP:0001663)3.29718302
15Abnormality of lateral ventricle (HP:0030047)3.21131285
16Impaired platelet aggregation (HP:0003540)3.20569259
17Abnormal platelet function (HP:0011869)3.20569259
18Hyperlipoproteinemia (HP:0010980)3.01346511
19Clumsiness (HP:0002312)3.01267786
20Abnormal respiratory motile cilium physiology (HP:0012261)2.99916124
21Dyschromatopsia (HP:0007641)2.98680027
22Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.97864475
23Spontaneous hematomas (HP:0007420)2.96201542
24Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.92068074
25Leukocytosis (HP:0001974)2.84047682
26Retinal dysplasia (HP:0007973)2.84018663
27Abnormality of the columella (HP:0009929)2.80030044
28Nasal polyposis (HP:0100582)2.71285458
29Abnormality of the frontal sinuses (HP:0002687)2.70738255
30Chronic sinusitis (HP:0011109)2.64372576
31Thyroid-stimulating hormone excess (HP:0002925)2.63180271
32Chronic otitis media (HP:0000389)2.62861031
33Aortic aneurysm (HP:0004942)2.51280769
34Abnormal respiratory epithelium morphology (HP:0012253)2.50922730
35Abnormal respiratory motile cilium morphology (HP:0005938)2.50922730
36Hyperalaninemia (HP:0003348)2.48637451
37Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.48637451
38Abnormality of alanine metabolism (HP:0010916)2.48637451
39Stomatitis (HP:0010280)2.39033208
40Atonic seizures (HP:0010819)2.35263035
41Encephalitis (HP:0002383)2.33335666
42Type II lissencephaly (HP:0007260)2.32474103
43Dynein arm defect of respiratory motile cilia (HP:0012255)2.31398025
44Absent/shortened dynein arms (HP:0200106)2.31398025
45Abnormality of the nasal mucosa (HP:0000433)2.30114278
46IgG deficiency (HP:0004315)2.29742203
47Conical tooth (HP:0000698)2.28739334
48Hypokalemic alkalosis (HP:0001949)2.28376278
49Rhinitis (HP:0012384)2.27694137
50Acanthocytosis (HP:0001927)2.26403221
51Weak cry (HP:0001612)2.24768591
52Decreased central vision (HP:0007663)2.22298793
53Generalized aminoaciduria (HP:0002909)2.21960209
54Hyporeflexia of lower limbs (HP:0002600)2.21528383
55Abnormality of the prostate (HP:0008775)2.17552672
56Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.17358595
57Increased circulating renin level (HP:0000848)2.15842063
583-Methylglutaconic aciduria (HP:0003535)2.14817078
59T lymphocytopenia (HP:0005403)2.14052865
60Resting tremor (HP:0002322)2.13688153
61Abnormality of T cell number (HP:0011839)2.13233192
62Joint swelling (HP:0001386)2.10859406
63Poikilocytosis (HP:0004447)2.09994003
64Metabolic alkalosis (HP:0200114)2.09543651
65Optic neuritis (HP:0100653)2.06567501
66Retrobulbar optic neuritis (HP:0100654)2.06567501
67Gastrointestinal infarctions (HP:0005244)2.06461216
68Basal ganglia calcification (HP:0002135)2.03805092
69Hyperglycinemia (HP:0002154)2.02997614
70Delayed CNS myelination (HP:0002188)2.01732740
71Gonadal dysgenesis (HP:0000133)2.00348361
72Renal cortical cysts (HP:0000803)1.96337717
73Bruising susceptibility (HP:0000978)1.90091942
74Hyperactive renin-angiotensin system (HP:0000841)1.89405534
75Reduced antithrombin III activity (HP:0001976)1.88009875
76Pancreatic cysts (HP:0001737)1.84584839
77Infertility (HP:0000789)1.84389909
78Chronic obstructive pulmonary disease (HP:0006510)1.84281097
79Obstructive lung disease (HP:0006536)1.84281097
80Male pseudohermaphroditism (HP:0000037)1.84243896
81Bronchiectasis (HP:0002110)1.83669387
82Tinnitus (HP:0000360)1.83501118
83Conjunctival telangiectasia (HP:0000524)1.83291839
84Arterial thrombosis (HP:0004420)1.82893609
85Paralysis (HP:0003470)1.82371225
86Increased density of long bones (HP:0006392)1.81958698
87Eczematoid dermatitis (HP:0000976)1.80548522
88Panhypogammaglobulinemia (HP:0003139)1.80543571
89Congenital sensorineural hearing impairment (HP:0008527)1.79502920
90Bulbar palsy (HP:0001283)1.75708176
91Postural instability (HP:0002172)1.74953610
92Increased IgM level (HP:0003496)1.73951914
93Clubbing of toes (HP:0100760)1.72958740
94Recurrent sinusitis (HP:0011108)1.72405423
95Colitis (HP:0002583)1.72032976
96Orchitis (HP:0100796)1.71966180
97Inflammation of the large intestine (HP:0002037)1.71484930
98Difficulty walking (HP:0002355)1.70827101
99Recurrent bronchitis (HP:0002837)1.70735540
100Myositis (HP:0100614)1.70242226

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PINK15.57452869
2MARK34.10442285
3MYLK4.07306566
4TXK3.23887481
5FES3.00314791
6MST42.75921156
7GRK62.73865783
8BMX2.34134543
9RIPK42.15041528
10TLK12.11618724
11BTK2.06397539
12OBSCN1.76660823
13IKBKB1.74172321
14ILK1.70428658
15ZAK1.68416042
16GRK51.64255165
17IKBKE1.62361982
18PTK2B1.35625011
19HCK1.33865197
20NLK1.29371107
21TEC1.29090727
22LATS11.25402961
23SYK1.23052179
24STK38L1.20249604
25MOS1.18784545
26MAP2K71.16728851
27EPHA31.12688644
28PAK11.12303365
29MAP4K11.11797662
30NEK21.09447070
31DAPK31.09078999
32MAP3K51.07789853
33MAP2K21.07361276
34CDK81.07075803
35PRKCQ1.05991898
36ZAP701.03465881
37FGR1.02788514
38PIM11.00347125
39BMPR20.96274664
40RPS6KA50.95295068
41FRK0.92880271
42DYRK1B0.91094319
43SGK2230.90852635
44SGK4940.90852635
45CSF1R0.89352523
46ADRBK20.89218859
47TNK20.89038526
48MAP3K10.88516712
49SGK20.86865421
50LYN0.86794689
51CSNK1G30.86689489
52ITK0.81434915
53MAP3K140.78349353
54DYRK30.77612973
55TGFBR20.74550674
56EPHB10.73283516
57MAP3K120.72661063
58TBK10.72396379
59STK380.71791077
60MAPK120.70526704
61GRK10.69763998
62RPS6KA40.69188188
63CSNK1A1L0.69111941
64CDK120.66454979
65IRAK10.64663215
66MAP3K130.63152289
67PIK3CG0.62549338
68JAK20.61442786
69GRK70.61092518
70IRAK20.59658950
71PKN10.59585676
72CSK0.59146113
73RET0.56319918
74MELK0.54876259
75BLK0.54583237
76TAOK30.54490157
77MAP3K70.54090715
78CSNK1G10.53980996
79DAPK10.52394127
80TESK20.50727145
81MAPK110.48052630
82JAK10.47874407
83LCK0.47573965
84ARAF0.47540915
85ROCK10.47050038
86STK30.45308483
87CDK30.43419577
88CSNK1G20.43384420
89PDK10.41927004
90CDK90.41196988
91PRKG10.38818821
92MAP4K20.37156255
93EIF2AK10.35790642
94RPS6KB10.35322721
95INSRR0.34957574
96MINK10.34013607
97BMPR1B0.33485213
98KDR0.33168089
99MAPKAPK30.32788122
100MAP2K10.32375694

Predicted pathways (KEGG)

RankGene SetZ-score
1Systemic lupus erythematosus_Homo sapiens_hsa053223.44060626
2Pathogenic Escherichia coli infection_Homo sapiens_hsa051303.11877484
3Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.82326540
4Platelet activation_Homo sapiens_hsa046112.72979067
5Nitrogen metabolism_Homo sapiens_hsa009102.55104938
6Alcoholism_Homo sapiens_hsa050342.48247289
7Olfactory transduction_Homo sapiens_hsa047402.47126863
8SNARE interactions in vesicular transport_Homo sapiens_hsa041302.07689067
9Hematopoietic cell lineage_Homo sapiens_hsa046401.95530821
10Primary immunodeficiency_Homo sapiens_hsa053401.94933049
11T cell receptor signaling pathway_Homo sapiens_hsa046601.90091694
12Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.86808858
13Graft-versus-host disease_Homo sapiens_hsa053321.79826140
14Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.67846706
15B cell receptor signaling pathway_Homo sapiens_hsa046621.67504877
16Allograft rejection_Homo sapiens_hsa053301.66187441
17Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.65879485
18Autoimmune thyroid disease_Homo sapiens_hsa053201.65240218
19Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.64423512
20Gap junction_Homo sapiens_hsa045401.64261583
21Vascular smooth muscle contraction_Homo sapiens_hsa042701.57204043
22Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.47391644
23Arachidonic acid metabolism_Homo sapiens_hsa005901.39747671
24Phagosome_Homo sapiens_hsa041451.28837510
25Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.28255312
26Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.26274036
27Toll-like receptor signaling pathway_Homo sapiens_hsa046201.20983623
28NF-kappa B signaling pathway_Homo sapiens_hsa040641.20769429
29Chemokine signaling pathway_Homo sapiens_hsa040621.19237888
30Apoptosis_Homo sapiens_hsa042101.19122023
31Staphylococcus aureus infection_Homo sapiens_hsa051501.14457042
32Viral carcinogenesis_Homo sapiens_hsa052031.13415044
33Intestinal immune network for IgA production_Homo sapiens_hsa046721.10938913
34Osteoclast differentiation_Homo sapiens_hsa043801.10619363
35Collecting duct acid secretion_Homo sapiens_hsa049661.10224215
36Measles_Homo sapiens_hsa051621.10097809
37NOD-like receptor signaling pathway_Homo sapiens_hsa046211.08606740
38Renin secretion_Homo sapiens_hsa049241.05763321
39Type I diabetes mellitus_Homo sapiens_hsa049401.04053470
40Asthma_Homo sapiens_hsa053101.02821978
41Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.01732810
42Herpes simplex infection_Homo sapiens_hsa051681.01232797
43Steroid hormone biosynthesis_Homo sapiens_hsa001400.97602147
44Chemical carcinogenesis_Homo sapiens_hsa052040.92845352
45Serotonergic synapse_Homo sapiens_hsa047260.91437860
46Antigen processing and presentation_Homo sapiens_hsa046120.89515449
47Leishmaniasis_Homo sapiens_hsa051400.89073771
48RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.88785886
49Transcriptional misregulation in cancer_Homo sapiens_hsa052020.87922749
50Malaria_Homo sapiens_hsa051440.85630351
51alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.84713392
52Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.80280671
53Legionellosis_Homo sapiens_hsa051340.80075992
54Phototransduction_Homo sapiens_hsa047440.79012413
55Oxytocin signaling pathway_Homo sapiens_hsa049210.78825603
56Circadian entrainment_Homo sapiens_hsa047130.76849695
57ECM-receptor interaction_Homo sapiens_hsa045120.74324727
58Endocytosis_Homo sapiens_hsa041440.73978210
59Viral myocarditis_Homo sapiens_hsa054160.73341269
60Rheumatoid arthritis_Homo sapiens_hsa053230.72729207
61Circadian rhythm_Homo sapiens_hsa047100.70385809
62Shigellosis_Homo sapiens_hsa051310.70176121
63Jak-STAT signaling pathway_Homo sapiens_hsa046300.69259812
64Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.65531372
65Tuberculosis_Homo sapiens_hsa051520.63570600
66Linoleic acid metabolism_Homo sapiens_hsa005910.62067249
67cGMP-PKG signaling pathway_Homo sapiens_hsa040220.60400269
68Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.59447926
69Gastric acid secretion_Homo sapiens_hsa049710.59252809
70Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.59135608
71Endometrial cancer_Homo sapiens_hsa052130.57944582
72Salivary secretion_Homo sapiens_hsa049700.57299923
73Calcium signaling pathway_Homo sapiens_hsa040200.56661426
74Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.55845472
75Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.54888974
76FoxO signaling pathway_Homo sapiens_hsa040680.53274590
77Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.53115645
78Taste transduction_Homo sapiens_hsa047420.47955907
79TNF signaling pathway_Homo sapiens_hsa046680.47677163
80Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.46483845
81beta-Alanine metabolism_Homo sapiens_hsa004100.46266765
82Regulation of autophagy_Homo sapiens_hsa041400.45626971
83Glutathione metabolism_Homo sapiens_hsa004800.42427117
84Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.42301138
85Salmonella infection_Homo sapiens_hsa051320.41991569
86Hepatitis B_Homo sapiens_hsa051610.41895171
87Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.39982220
88Pertussis_Homo sapiens_hsa051330.39924854
89Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.39860927
90Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.35403323
91Leukocyte transendothelial migration_Homo sapiens_hsa046700.35281420
92MAPK signaling pathway_Homo sapiens_hsa040100.34874475
93Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.34854660
94Morphine addiction_Homo sapiens_hsa050320.34676304
95Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.34500443
96Regulation of actin cytoskeleton_Homo sapiens_hsa048100.33862447
97Dilated cardiomyopathy_Homo sapiens_hsa054140.31280720
98Non-small cell lung cancer_Homo sapiens_hsa052230.29974302
99Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.28541805
100TGF-beta signaling pathway_Homo sapiens_hsa043500.27196698

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