ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	positive regulation of catecholamine secretion (GO:0033605)	9.64443018
2	regulation of phosphoprotein phosphatase activity (GO:0043666)	9.21838898
3	acrosome reaction (GO:0007340)	8.93874705
4	multicellular organism reproduction (GO:0032504)	8.44665797
5	negative regulation of retinoic acid receptor signaling pathway (GO:0048387)	8.28152485
6	histone H3-K9 demethylation (GO:0033169)	8.04319329
7	positive regulation of synaptic transmission, dopaminergic (GO:0032226)	7.97982217
8	spermatid development (GO:0007286)	7.92409388
9	binding of sperm to zona pellucida (GO:0007339)	7.70556708
10	regulation of retinoic acid receptor signaling pathway (GO:0048385)	7.03116056
11	sperm motility (GO:0030317)	6.76526197
12	synapsis (GO:0007129)	6.26418359
13	sperm-egg recognition (GO:0035036)	6.25171499
14	motile cilium assembly (GO:0044458)	6.03204047
15	regulation of oxidative stress-induced neuron death (GO:1903203)	5.83232832
16	reproduction (GO:0000003)	5.79787925
17	single fertilization (GO:0007338)	5.47429239
18	relaxation of smooth muscle (GO:0044557)	5.42881117
19	cell-cell recognition (GO:0009988)	5.39450980
20	epithelial cilium movement (GO:0003351)	5.31315658
21	chromosome organization involved in meiosis (GO:0070192)	5.24051289
22	piRNA metabolic process (GO:0034587)	5.03736017
23	germ cell development (GO:0007281)	4.95672429
24	axonemal dynein complex assembly (GO:0070286)	4.93090847
25	synaptonemal complex assembly (GO:0007130)	4.85687391
26	negative regulation of cardiac muscle cell apoptotic process (GO:0010667)	4.72198008
27	meiotic nuclear division (GO:0007126)	4.68699135
28	synaptonemal complex organization (GO:0070193)	4.64622170
29	potassium ion export (GO:0071435)	4.64085258
30	regulation of oxidative phosphorylation (GO:0002082)	4.62667898
31	male sex determination (GO:0030238)	4.61213589
32	protein-DNA complex disassembly (GO:0032986)	4.53726637
33	nucleosome disassembly (GO:0006337)	4.53726637
34	calcium ion-dependent exocytosis (GO:0017156)	4.51947953
35	polyamine biosynthetic process (GO:0006596)	4.46302396
36	regulation of alternative mRNA splicing, via spliceosome (GO:0000381)	4.44925522
37	regulation of acrosome reaction (GO:0060046)	4.40897689
38	regulation of autophagic vacuole assembly (GO:2000785)	4.35606789
39	cilium or flagellum-dependent cell motility (GO:0001539)	4.33226907
40	organic cation transport (GO:0015695)	4.27783158
41	activation of protein kinase B activity (GO:0032148)	4.26525741
42	cilium movement (GO:0003341)	4.25756322
43	histone exchange (GO:0043486)	4.17908430
44	fusion of sperm to egg plasma membrane (GO:0007342)	4.16542747
45	TOR signaling (GO:0031929)	4.08257779
46	phosphatidylethanolamine biosynthetic process (GO:0006646)	4.05977239
47	fertilization (GO:0009566)	4.04224051
48	cGMP-mediated signaling (GO:0019934)	4.04208431
49	oocyte development (GO:0048599)	4.02626122
50	amine biosynthetic process (GO:0009309)	4.00249670
51	ventricular system development (GO:0021591)	3.99869107
52	negative regulation of hydrogen peroxide-induced cell death (GO:1903206)	3.99072361
53	cellular process involved in reproduction in multicellular organism (GO:0022412)	3.93669038
54	protein polymerization (GO:0051258)	3.92165777
55	Leydig cell differentiation (GO:0033327)	3.85957562
56	regulation of dopamine secretion (GO:0014059)	3.82277544
57	DNA double-strand break processing (GO:0000729)	3.81265173
58	male meiosis I (GO:0007141)	3.80958130
59	DNA methylation involved in gamete generation (GO:0043046)	3.80546014
60	oogenesis (GO:0048477)	3.80115339
61	phosphatidylethanolamine metabolic process (GO:0046337)	3.78673882
62	cellular biogenic amine biosynthetic process (GO:0042401)	3.73216269
63	positive regulation of glycolytic process (GO:0045821)	3.71550980
64	glutamine family amino acid catabolic process (GO:0009065)	3.71125043
65	glycogen metabolic process (GO:0005977)	3.65877119
66	regulation of synaptic transmission, dopaminergic (GO:0032225)	3.62514268
67	negative regulation of response to reactive oxygen species (GO:1901032)	3.61367556
68	glucan metabolic process (GO:0044042)	3.60921607
69	cellular glucan metabolic process (GO:0006073)	3.60921607
70	regulation of vacuole organization (GO:0044088)	3.58282997
71	positive regulation of amine transport (GO:0051954)	3.52839017
72	acrosome assembly (GO:0001675)	3.52712338
73	tryptophan catabolic process (GO:0006569)	3.47961880
74	indole-containing compound catabolic process (GO:0042436)	3.47961880
75	indolalkylamine catabolic process (GO:0046218)	3.47961880
76	mitochondrion degradation (GO:0000422)	3.45513564
77	regulation of hydrogen peroxide-induced cell death (GO:1903205)	3.41501942
78	xenobiotic catabolic process (GO:0042178)	3.40526733
79	regulation of RIG-I signaling pathway (GO:0039535)	3.37898207
80	androgen biosynthetic process (GO:0006702)	3.34715327
81	regulation of cellular respiration (GO:0043457)	3.32156562
82	response to acidic pH (GO:0010447)	3.27595060
83	intraciliary transport (GO:0042073)	3.23937861
84	negative regulation of inclusion body assembly (GO:0090084)	3.22100603
85	plasma membrane fusion (GO:0045026)	3.16734510
86	meiotic cell cycle process (GO:1903046)	3.14466691
87	regulation of phosphatase activity (GO:0010921)	3.13132822
88	N-terminal protein amino acid acetylation (GO:0006474)	3.11648814
89	histone demethylation (GO:0016577)	3.10801389
90	histone lysine demethylation (GO:0070076)	3.10043257
91	aspartate family amino acid catabolic process (GO:0009068)	3.08884516
92	poly(A)+ mRNA export from nucleus (GO:0016973)	3.04074609
93	tongue development (GO:0043586)	3.02522843
94	positive regulation of meiotic cell cycle (GO:0051446)	3.02154212
95	coenzyme catabolic process (GO:0009109)	3.02037200
96	regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)	2.98346059
97	cellular response to toxic substance (GO:0097237)	2.96177115
98	membrane repolarization during action potential (GO:0086011)	2.95887507
99	meiosis I (GO:0007127)	2.94950261
100	male meiosis (GO:0007140)	10.3501789

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	BP1_19119308_ChIP-ChIP_Hs578T_Human	6.66635821
2	IGF1R_20145208_ChIP-Seq_DFB_Human	4.65683878
3	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	4.26221730
4	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	4.02330571
5	VDR_22108803_ChIP-Seq_LS180_Human	3.46831218
6	EZH2_22144423_ChIP-Seq_EOC_Human	3.08643340
7	ESR1_20079471_ChIP-ChIP_T-47D_Human	2.92903693
8	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	2.59290511
9	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.36115815
10	FUS_26573619_Chip-Seq_HEK293_Human	2.23095885
11	GBX2_23144817_ChIP-Seq_PC3_Human	2.18716392
12	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.01103141
13	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	11.3535232
14	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.94634575
15	IRF1_19129219_ChIP-ChIP_H3396_Human	1.84739899
16	AR_21909140_ChIP-Seq_LNCAP_Human	1.65855467
17	BCAT_22108803_ChIP-Seq_LS180_Human	1.65408991
18	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.63366691
19	NANOG_20526341_ChIP-Seq_ESCs_Human	1.63007295
20	ER_23166858_ChIP-Seq_MCF-7_Human	1.62538236
21	SMAD4_21799915_ChIP-Seq_A2780_Human	1.60651399
22	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.57104384
23	P300_19829295_ChIP-Seq_ESCs_Human	1.55503990
24	RAC3_21632823_ChIP-Seq_H3396_Human	1.52313280
25	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.52010720
26	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.51934144
27	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.51934144
28	AHR_22903824_ChIP-Seq_MCF-7_Human	1.50124424
29	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.49091998
30	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.47940837
31	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.47354631
32	ZNF274_21170338_ChIP-Seq_K562_Hela	1.46899747
33	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.45400456
34	CBP_20019798_ChIP-Seq_JUKART_Human	1.39500705
35	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.39500705
36	ERA_21632823_ChIP-Seq_H3396_Human	1.36816343
37	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.35353191
38	RUNX2_22187159_ChIP-Seq_PCA_Human	1.34929371
39	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.33945771
40	OCT4_20526341_ChIP-Seq_ESCs_Human	1.29852133
41	AR_25329375_ChIP-Seq_VCAP_Human	1.28119005
42	OCT1_27270436_Chip-Seq_PROSTATE_Human	1.27871073
43	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.26985221
44	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.26693046
45	TBL1_22424771_ChIP-Seq_293T_Human	1.26606048
46	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.24030995
47	STAT3_23295773_ChIP-Seq_U87_Human	1.23916599
48	SOX2_19829295_ChIP-Seq_ESCs_Human	1.23762140
49	NANOG_19829295_ChIP-Seq_ESCs_Human	1.23762140
50	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.23448170
51	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.23372646
52	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.21876481
53	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.19368682
54	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.15760213
55	MYC_19829295_ChIP-Seq_ESCs_Human	1.15291581
56	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.13494112
57	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.13054276
58	MYC_18940864_ChIP-ChIP_HL60_Human	1.11367670
59	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.10712574
60	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.06614651
61	TAF15_26573619_Chip-Seq_HEK293_Human	1.05159181
62	TCF4_23295773_ChIP-Seq_U87_Human	1.04391209
63	TP53_18474530_ChIP-ChIP_U2OS_Human	1.04292918
64	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.03221224
65	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.02534986
66	AR_21572438_ChIP-Seq_LNCaP_Human	1.00520803
67	NCOR_22424771_ChIP-Seq_293T_Human	0.99863481
68	GATA3_26560356_Chip-Seq_TH2_Human	0.99076058
69	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.97731468
70	HOXB7_26014856_ChIP-Seq_BT474_Human	0.94852214
71	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	0.93815064
72	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	0.92507762
73	TCF4_22108803_ChIP-Seq_LS180_Human	0.91627580
74	EWS_26573619_Chip-Seq_HEK293_Human	0.91075984
75	RXR_22108803_ChIP-Seq_LS180_Human	0.88643039
76	PKCTHETA_26484144_Chip-Seq_BREAST_Human	0.88508271
77	TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human	0.87963758
78	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	0.87788718
79	P53_22127205_ChIP-Seq_FIBROBLAST_Human	0.87575325
80	TP63_23658742_ChIP-Seq_EP156T_Human	0.87505952
81	CBP_21632823_ChIP-Seq_H3396_Human	0.87352435
82	PHF8_20622853_ChIP-Seq_HELA_Human	0.86322876
83	ERG_20517297_ChIP-Seq_VCAP_Human	0.85739577
84	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	0.85720916
85	NFYB_21822215_ChIP-Seq_K562_Human	0.85486847
86	FOXM1_26456572_ChIP-Seq_MCF-7_Human	0.85271060
87	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.85267439
88	CBX2_27304074_Chip-Seq_ESCs_Mouse	0.82891511
89	GATA3_26560356_Chip-Seq_TH1_Human	0.81818891
90	RBPJ_21746931_ChIP-Seq_IB4_Human	0.81744611
91	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	0.81343629
92	EP300_21415370_ChIP-Seq_HL-1_Mouse	0.81050395
93	ETV1_20927104_ChIP-Seq_GIST48_Human	0.80811035
94	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.80290361
95	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	0.79193025
96	BMI1_23680149_ChIP-Seq_NPCS_Mouse	0.79106276
97	SOX2_19030024_ChIP-ChIP_MESCs_Mouse	0.78260220
98	EED_16625203_ChIP-ChIP_MESCs_Mouse	0.78255668
99	KAP1_22055183_ChIP-Seq_ESCs_Mouse	0.78096039
100	ELF5_23300383_ChIP-Seq_T47D_Human	0.77795846

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005410_abnormal_fertilization	7.57095339
2	MP0002837_dystrophic_cardiac_calcinosis	4.79707437
3	MP0003315_abnormal_perineum_morphology	4.56873317
4	MP0002160_abnormal_reproductive_system	4.42373638
5	MP0003136_yellow_coat_color	4.39645501
6	MP0008004_abnormal_stomach_pH	4.25369273
7	MP0001929_abnormal_gametogenesis	3.20923040
8	MP0005360_urolithiasis	2.96487335
9	MP0003698_abnormal_male_reproductive	2.92707697
10	MP0001984_abnormal_olfaction	2.44493867
11	MP0002102_abnormal_ear_morphology	2.44039877
12	MP0008877_abnormal_DNA_methylation	2.27616076
13	MP0005389_reproductive_system_phenotype	2.27591004
14	MP0005647_abnormal_sex_gland	2.21989698
15	MP0002210_abnormal_sex_determination	2.19024695
16	MP0001664_abnormal_digestion	1.88889359
17	MP0000537_abnormal_urethra_morphology	1.87988385
18	MP0006072_abnormal_retinal_apoptosis	1.87638341
19	MP0005646_abnormal_pituitary_gland	1.83047253
20	MP0003045_fibrosis	1.82956595
21	MP0005058_abnormal_lysosome_morphology	1.78213173
22	MP0005499_abnormal_olfactory_system	1.78036654
23	MP0005394_taste/olfaction_phenotype	1.78036654
24	MP0002132_abnormal_respiratory_system	1.75533719
25	MP0008058_abnormal_DNA_repair	1.74209420
26	MP0009697_abnormal_copulation	1.73234034
27	MP0001145_abnormal_male_reproductive	1.72210962
28	MP0000653_abnormal_sex_gland	1.71093389
29	MP0005187_abnormal_penis_morphology	1.68919322
30	MP0000372_irregular_coat_pigmentation	1.66622440
31	MP0002161_abnormal_fertility/fecundity	1.64401262
32	MP0008775_abnormal_heart_ventricle	1.60222713
33	MP0004134_abnormal_chest_morphology	1.56537433
34	MP0010368_abnormal_lymphatic_system	1.47854587
35	MP0003718_maternal_effect	1.42880664
36	MP0010386_abnormal_urinary_bladder	1.41768217
37	MP0003693_abnormal_embryo_hatching	1.41578728
38	MP0004381_abnormal_hair_follicle	1.36906647
39	MP0002127_abnormal_cardiovascular_syste	1.32863309
40	MP0001905_abnormal_dopamine_level	1.30451492
41	MP0006035_abnormal_mitochondrial_morpho	1.27176476
42	MP0003936_abnormal_reproductive_system	1.16740081
43	MP0000427_abnormal_hair_cycle	1.09489319
44	MP0005253_abnormal_eye_physiology	1.06660272
45	MP0000538_abnormal_urinary_bladder	1.04326681
46	MP0002090_abnormal_vision	1.04223664
47	MP0002822_catalepsy	1.02636511
48	MP0010234_abnormal_vibrissa_follicle	1.00786558
49	MP0008995_early_reproductive_senescence	1.00222100
50	MP0006036_abnormal_mitochondrial_physio	0.95945840
51	MP0005174_abnormal_tail_pigmentation	0.93390475
52	MP0008789_abnormal_olfactory_epithelium	0.93153031
53	MP0001919_abnormal_reproductive_system	0.89330247
54	MP0004085_abnormal_heartbeat	0.86169114
55	MP0001188_hyperpigmentation	0.85999095
56	MP0004084_abnormal_cardiac_muscle	0.84024304
57	MP0002272_abnormal_nervous_system	0.83896294
58	MP0000465_gastrointestinal_hemorrhage	0.79965700
59	MP0001501_abnormal_sleep_pattern	0.79639288
60	MP0005075_abnormal_melanosome_morpholog	0.78770058
61	MP0002638_abnormal_pupillary_reflex	0.78615000
62	MP0000678_abnormal_parathyroid_gland	0.75367687
63	MP0002233_abnormal_nose_morphology	0.74819951
64	MP0000631_abnormal_neuroendocrine_gland	0.74585791
65	MP0001119_abnormal_female_reproductive	0.70895937
66	MP0000470_abnormal_stomach_morphology	0.69566605
67	MP0000015_abnormal_ear_pigmentation	0.69416807
68	MP0003868_abnormal_feces_composition	0.69117347
69	MP0003385_abnormal_body_wall	0.68418696
70	MP0005330_cardiomyopathy	0.68050759
71	MP0003632_abnormal_nervous_system	0.66006376
72	MP0003950_abnormal_plasma_membrane	0.65478105
73	MP0005395_other_phenotype	0.64831118
74	MP0003699_abnormal_female_reproductive	0.64575591
75	MP0001529_abnormal_vocalization	0.62978840
76	MP0004215_abnormal_myocardial_fiber	0.62878362
77	MP0001756_abnormal_urination	0.61161954
78	MP0005248_abnormal_Harderian_gland	0.60774376
79	MP0006276_abnormal_autonomic_nervous	0.60361937
80	MP0002269_muscular_atrophy	0.59415338
81	MP0005551_abnormal_eye_electrophysiolog	0.58883498
82	MP0006292_abnormal_olfactory_placode	0.55961429
83	MP0001502_abnormal_circadian_rhythm	0.53582058
84	MP0009250_abnormal_appendicular_skeleto	0.52606686
85	MP0005620_abnormal_muscle_contractility	0.51991644
86	MP0004036_abnormal_muscle_relaxation	0.51625632
87	MP0003631_nervous_system_phenotype	0.51013232
88	MP0001968_abnormal_touch/_nociception	0.50549245
89	MP0001764_abnormal_homeostasis	0.49460403
90	MP0002163_abnormal_gland_morphology	0.48526984
91	MP0002229_neurodegeneration	0.47848003
92	MP0000230_abnormal_systemic_arterial	0.47413933
93	MP0000733_abnormal_muscle_development	0.47321784
94	MP0000049_abnormal_middle_ear	0.46660534
95	MP0009046_muscle_twitch	0.46479810
96	MP0003121_genomic_imprinting	0.46432936
97	MP0003119_abnormal_digestive_system	0.45782025
98	MP0001666_abnormal_nutrient_absorption	0.45147352
99	MP0003137_abnormal_impulse_conducting	0.44956482
100	MP0005220_abnormal_exocrine_pancreas	0.43152844

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormal sex determination (HP:0012244)	6.37330066
2	Sex reversal (HP:0012245)	6.37330066
3	Hypoplasia of the uterus (HP:0000013)	6.29905281
4	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	5.44612496
5	Dynein arm defect of respiratory motile cilia (HP:0012255)	4.98769580
6	Absent/shortened dynein arms (HP:0200106)	4.98769580
7	Resting tremor (HP:0002322)	4.87755283
8	Abnormal ciliary motility (HP:0012262)	4.76837627
9	Abnormal respiratory motile cilium physiology (HP:0012261)	4.72996940
10	Aplasia/hypoplasia of the uterus (HP:0008684)	4.69949891
11	Gonadal dysgenesis (HP:0000133)	4.51073662
12	Reduced antithrombin III activity (HP:0001976)	4.06700675
13	Male pseudohermaphroditism (HP:0000037)	3.98484398
14	Infertility (HP:0000789)	3.89149698
15	Abnormality of the columella (HP:0009929)	3.78845782
16	Abnormal respiratory epithelium morphology (HP:0012253)	3.74601701
17	Abnormal respiratory motile cilium morphology (HP:0005938)	3.74601701
18	Median cleft lip (HP:0000161)	3.65119218
19	Rhinitis (HP:0012384)	3.58233627
20	Decreased activity of mitochondrial respiratory chain (HP:0008972)	3.53652054
21	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	3.53652054
22	Facial hemangioma (HP:0000329)	3.35875777
23	Hypothermia (HP:0002045)	3.26290554
24	Short tibia (HP:0005736)	3.26267783
25	Urinary urgency (HP:0000012)	3.22454053
26	Absent thumb (HP:0009777)	3.17239386
27	Aplasia/Hypoplasia of the tibia (HP:0005772)	3.07871602
28	Colitis (HP:0002583)	2.98453435
29	Ventricular fibrillation (HP:0001663)	2.95365911
30	Cerebellar dysplasia (HP:0007033)	2.91724290
31	Germ cell neoplasia (HP:0100728)	2.88177737
32	Postural instability (HP:0002172)	2.83059451
33	Premature ovarian failure (HP:0008209)	2.82863863
34	Atonic seizures (HP:0010819)	2.65956449
35	Acute hepatic failure (HP:0006554)	2.50636490
36	Inability to walk (HP:0002540)	2.43195492
37	Thoracolumbar scoliosis (HP:0002944)	2.42010859
38	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.41601135
39	Retinal atrophy (HP:0001105)	2.40744807
40	Sensory axonal neuropathy (HP:0003390)	2.36638309
41	Self-mutilation (HP:0000742)	2.33873746
42	Chronic bronchitis (HP:0004469)	2.30078290
43	Inflammation of the large intestine (HP:0002037)	2.29099875
44	Facial diplegia (HP:0001349)	2.28885765
45	Congenital sensorineural hearing impairment (HP:0008527)	2.28148293
46	Tubulointerstitial nephritis (HP:0001970)	2.23758642
47	Type II lissencephaly (HP:0007260)	2.21378322
48	Microglossia (HP:0000171)	2.19800010
49	Abnormality of lateral ventricle (HP:0030047)	2.18198846
50	Anterior segment dysgenesis (HP:0007700)	2.17683340
51	Short chin (HP:0000331)	2.15467376
52	Proximal placement of thumb (HP:0009623)	2.14154119
53	Decreased number of peripheral myelinated nerve fibers (HP:0003380)	2.11240185
54	Nasal polyposis (HP:0100582)	2.10171560
55	Bronchiectasis (HP:0002110)	2.08415444
56	Stenosis of the external auditory canal (HP:0000402)	2.08159447
57	Thoracic kyphosis (HP:0002942)	2.07399464
58	Capillary hemangiomas (HP:0005306)	2.06572390
59	Abnormality of the intrinsic pathway (HP:0010989)	2.02779761
60	Gastrointestinal inflammation (HP:0004386)	2.02538692
61	Conical tooth (HP:0000698)	2.02409291
62	Small epiphyses (HP:0010585)	2.02076630
63	Volvulus (HP:0002580)	2.01443814
64	Abnormality of the ileum (HP:0001549)	1.99629422
65	Flattened epiphyses (HP:0003071)	1.99052048
66	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.98287306
67	Cutaneous melanoma (HP:0012056)	1.97820817
68	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.97136398
69	Abnormal protein N-linked glycosylation (HP:0012347)	1.97136398
70	Abnormal protein glycosylation (HP:0012346)	1.97136398
71	Abnormal glycosylation (HP:0012345)	1.97136398
72	Abnormality of dental color (HP:0011073)	1.96717118
73	Occipital encephalocele (HP:0002085)	1.95063418
74	Polyneuropathy (HP:0001271)	1.93700564
75	Centrally nucleated skeletal muscle fibers (HP:0003687)	1.93329111
76	Coxa valga (HP:0002673)	1.92786682
77	Abnormality of the thoracic spine (HP:0100711)	1.92226889
78	Urethral obstruction (HP:0000796)	1.91934047
79	Abnormality of the preputium (HP:0100587)	1.90492938
80	Abnormality of the lumbar spine (HP:0100712)	1.88988723
81	Abnormality of the frontal sinuses (HP:0002687)	1.86354464
82	Abnormality of male internal genitalia (HP:0000022)	1.86128946
83	Zonular cataract (HP:0010920)	1.85969987
84	Meckel diverticulum (HP:0002245)	1.85173840
85	Pancreatic fibrosis (HP:0100732)	1.82193783
86	Retinal dysplasia (HP:0007973)	1.81808475
87	Abnormality of the incisor (HP:0000676)	1.79806517
88	Methylmalonic acidemia (HP:0002912)	1.78457453
89	Deviation of the thumb (HP:0009603)	1.76714026
90	Lipid accumulation in hepatocytes (HP:0006561)	1.76531780
91	Chromsome breakage (HP:0040012)	1.76469541
92	Ketosis (HP:0001946)	1.75462412
93	Anteriorly placed anus (HP:0001545)	1.73680419
94	White forelock (HP:0002211)	1.73571775
95	Oligodactyly (hands) (HP:0001180)	1.73359262
96	Renal cortical cysts (HP:0000803)	1.72272303
97	Ectopic kidney (HP:0000086)	1.71617666
98	Delayed gross motor development (HP:0002194)	1.71035279
99	Abnormal rod and cone electroretinograms (HP:0008323)	1.70316286
100	Increased IgM level (HP:0003496)	1.69851720

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PINK1	9.88180224
2	MARK3	5.51617884
3	TLK1	4.99037820
4	ZAK	4.32687127
5	MYLK	2.80003320
6	RPS6KA5	2.71456035
7	FRK	2.63903276
8	ACVR1B	2.53774519
9	LATS1	1.95016147
10	NEK2	1.88630625
11	BMPR1B	1.84663014
12	MAP3K10	1.73227681
13	BRD4	1.46057424
14	OBSCN	1.38130135
15	VRK1	1.36962130
16	WNK3	1.33259653
17	STK16	1.27288209
18	STK38L	1.26497722
19	MELK	1.15265796
20	FGFR2	1.12657862
21	PLK4	1.10475823
22	GRK1	1.07668060
23	MAP2K7	1.06533524
24	PRKCQ	1.01939614
25	MST1R	1.01454797
26	TXK	0.99454762
27	STK38	0.98059607
28	AURKA	0.89470244
29	CDK19	0.88362076
30	NEK6	0.87246141
31	ILK	0.82732827
32	STK24	0.79535518
33	CDK14	0.79154153
34	KDR	0.77893534
35	CLK1	0.77621976
36	CDK3	0.74688025
37	LATS2	0.73942552
38	PKN1	0.71480658
39	TRIM28	0.70113967
40	MAPKAPK3	0.58873633
41	NUAK1	0.58771420
42	MAP3K5	0.58381026
43	GRK6	0.58357046
44	CSNK1G2	0.57232812
45	DYRK3	0.56930476
46	ATM	0.56680569
47	AURKB	0.55282386
48	CSNK1A1L	0.55183857
49	CSNK1G1	0.53908160
50	PLK1	0.53893404
51	MKNK1	0.53620594
52	ROCK1	0.51799904
53	PAK1	0.51284136
54	MAP3K3	0.49743878
55	CSNK1G3	0.49122843
56	PTK2B	0.46943272
57	CDK8	0.45008815
58	PLK2	0.42481401
59	SGK223	0.39964468
60	SGK494	0.39964468
61	MET	0.36468611
62	EGFR	0.36317953
63	TGFBR1	0.35695683
64	IRAK2	0.35392703
65	SRPK1	0.35355535
66	MAPK15	0.35287100
67	CAMK1	0.33678954
68	PRKG1	0.33457341
69	DYRK2	0.31825935
70	MAPKAPK5	0.31445064
71	TIE1	0.31127871
72	RPS6KB1	0.31072767
73	PAK2	0.30787374
74	CDK5	0.30548882
75	TESK2	0.30406603
76	STK39	0.29826672
77	RET	0.27996531
78	ARAF	0.27899837
79	OXSR1	0.27317820
80	FGR	0.26183473
81	PRKACB	0.24396974
82	RAF1	0.22262300
83	TNIK	0.21541323
84	CHEK2	0.20862897
85	MAP3K13	0.20726733
86	CDC42BPA	0.20400524
87	ADRBK2	0.20205100
88	DAPK3	0.18791974
89	WNK4	0.16908943
90	STK3	0.15621183
91	IGF1R	0.15545776
92	CHEK1	0.15300201
93	RPS6KA3	0.14945831
94	CAMK4	0.14846331
95	NME1	0.13474231
96	IKBKE	0.13308286
97	NTRK3	0.12668352
98	CSNK2A1	0.12195885
99	EIF2AK3	0.11212303
100	PHKG2	0.11051727

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	7.51298819
2	Gap junction_Homo sapiens_hsa04540	4.64947596
3	Systemic lupus erythematosus_Homo sapiens_hsa05322	3.29956644
4	Nitrogen metabolism_Homo sapiens_hsa00910	2.98065764
5	Hedgehog signaling pathway_Homo sapiens_hsa04340	2.95984142
6	Apoptosis_Homo sapiens_hsa04210	2.48357558
7	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.48157885
8	Alcoholism_Homo sapiens_hsa05034	2.46441988
9	Phagosome_Homo sapiens_hsa04145	2.16254105
10	Propanoate metabolism_Homo sapiens_hsa00640	2.12312986
11	Basal transcription factors_Homo sapiens_hsa03022	2.11288067
12	Olfactory transduction_Homo sapiens_hsa04740	2.10899549
13	Fanconi anemia pathway_Homo sapiens_hsa03460	2.04584007
14	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.80634104
15	Butanoate metabolism_Homo sapiens_hsa00650	1.78614220
16	Arginine biosynthesis_Homo sapiens_hsa00220	1.54669960
17	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.45705569
18	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.44026377
19	Chemical carcinogenesis_Homo sapiens_hsa05204	1.31769050
20	Glutathione metabolism_Homo sapiens_hsa00480	1.30274379
21	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.30225501
22	RNA transport_Homo sapiens_hsa03013	1.29873450
23	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.28877375
24	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.28131517
25	Oocyte meiosis_Homo sapiens_hsa04114	1.27259551
26	Pyruvate metabolism_Homo sapiens_hsa00620	1.18440391
27	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.14027556
28	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	1.12769845
29	mRNA surveillance pathway_Homo sapiens_hsa03015	1.08861277
30	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	1.02197080
31	Circadian rhythm_Homo sapiens_hsa04710	1.01811472
32	Tryptophan metabolism_Homo sapiens_hsa00380	0.98838398
33	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.96348322
34	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.93608729
35	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.93134426
36	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.92774155
37	Homologous recombination_Homo sapiens_hsa03440	0.92008147
38	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.88597708
39	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.87584388
40	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.81936979
41	Taste transduction_Homo sapiens_hsa04742	0.80708419
42	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.79358192
43	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.79201946
44	Purine metabolism_Homo sapiens_hsa00230	0.76353559
45	Linoleic acid metabolism_Homo sapiens_hsa00591	0.75490086
46	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.74416192
47	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.73607001
48	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.72395581
49	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.71461342
50	PPAR signaling pathway_Homo sapiens_hsa03320	0.71097474
51	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.69798493
52	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.65931771
53	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.64790518
54	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.64317515
55	DNA replication_Homo sapiens_hsa03030	0.63639282
56	Renin secretion_Homo sapiens_hsa04924	0.63411505
57	beta-Alanine metabolism_Homo sapiens_hsa00410	0.62259035
58	RNA degradation_Homo sapiens_hsa03018	0.59915020
59	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.59114080
60	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.57970096
61	Phototransduction_Homo sapiens_hsa04744	0.57305655
62	Pyrimidine metabolism_Homo sapiens_hsa00240	0.57077233
63	Glycosaminoglycan degradation_Homo sapiens_hsa00531	0.55093048
64	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.54462518
65	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.53938142
66	Retinol metabolism_Homo sapiens_hsa00830	0.53652620
67	Phenylalanine metabolism_Homo sapiens_hsa00360	0.49419208
68	Regulation of autophagy_Homo sapiens_hsa04140	0.49145764
69	Calcium signaling pathway_Homo sapiens_hsa04020	0.48090894
70	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.47344401
71	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.40613613
72	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.39241389
73	Serotonergic synapse_Homo sapiens_hsa04726	0.38827903
74	Tyrosine metabolism_Homo sapiens_hsa00350	0.38287795
75	Glucagon signaling pathway_Homo sapiens_hsa04922	0.37800313
76	Non-homologous end-joining_Homo sapiens_hsa03450	0.35829502
77	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.35732971
78	Viral carcinogenesis_Homo sapiens_hsa05203	0.35346120
79	Metabolic pathways_Homo sapiens_hsa01100	0.33729174
80	Parkinsons disease_Homo sapiens_hsa05012	0.33091308
81	Wnt signaling pathway_Homo sapiens_hsa04310	0.33090664
82	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.31001265
83	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.30235631
84	RNA polymerase_Homo sapiens_hsa03020	0.27541077
85	GABAergic synapse_Homo sapiens_hsa04727	0.26262612
86	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.25491543
87	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.25277638
88	Sphingolipid metabolism_Homo sapiens_hsa00600	0.24686225
89	Circadian entrainment_Homo sapiens_hsa04713	0.24269292
90	Spliceosome_Homo sapiens_hsa03040	0.23790469
91	Mismatch repair_Homo sapiens_hsa03430	0.23439879
92	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.23034853
93	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.22757433
94	Ribosome_Homo sapiens_hsa03010	0.22654885
95	Herpes simplex infection_Homo sapiens_hsa05168	0.22584454
96	Primary immunodeficiency_Homo sapiens_hsa05340	0.22314580
97	Peroxisome_Homo sapiens_hsa04146	0.21708667
98	Gastric acid secretion_Homo sapiens_hsa04971	0.19884961
99	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.19714044
100	Tight junction_Homo sapiens_hsa04530	0.17027873

PPP1R2P10

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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