ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	male meiosis (GO:0007140)	9.75569157
2	acrosome reaction (GO:0007340)	9.26120130
3	spermatid development (GO:0007286)	8.70688206
4	sperm motility (GO:0030317)	8.67979822
5	multicellular organism reproduction (GO:0032504)	8.12461165
6	regulation of oxidative stress-induced neuron death (GO:1903203)	7.68134559
7	regulation of oxidative phosphorylation (GO:0002082)	7.61940725
8	binding of sperm to zona pellucida (GO:0007339)	7.52450197
9	relaxation of smooth muscle (GO:0044557)	7.44380781
10	motile cilium assembly (GO:0044458)	7.38995912
11	axonemal dynein complex assembly (GO:0070286)	6.65444731
12	protein-DNA complex disassembly (GO:0032986)	6.64100890
13	nucleosome disassembly (GO:0006337)	6.64100890
14	potassium ion export (GO:0071435)	6.56646903
15	polyamine biosynthetic process (GO:0006596)	6.55984983
16	* regulation of phosphoprotein phosphatase activity (GO:0043666)	6.54095612
17	sperm-egg recognition (GO:0035036)	6.32064072
18	synapsis (GO:0007129)	5.91128519
19	organic cation transport (GO:0015695)	5.89922980
20	activation of protein kinase B activity (GO:0032148)	5.81850357
21	cilium or flagellum-dependent cell motility (GO:0001539)	5.77305189
22	negative regulation of hydrogen peroxide-induced cell death (GO:1903206)	5.71254814
23	epithelial cilium movement (GO:0003351)	5.66344460
24	reproduction (GO:0000003)	5.66114881
25	Leydig cell differentiation (GO:0033327)	5.61790540
26	cell-cell recognition (GO:0009988)	5.53993244
27	cGMP-mediated signaling (GO:0019934)	5.38894115
28	single fertilization (GO:0007338)	5.38457159
29	male sex determination (GO:0030238)	5.36663619
30	regulation of hydrogen peroxide-induced cell death (GO:1903205)	5.21906512
31	negative regulation of response to reactive oxygen species (GO:1901032)	5.20080806
32	regulation of dopamine secretion (GO:0014059)	5.16628324
33	regulation of cellular respiration (GO:0043457)	5.11407139
34	negative regulation of cardiac muscle cell apoptotic process (GO:0010667)	5.04955425
35	germ cell development (GO:0007281)	5.04521697
36	TOR signaling (GO:0031929)	4.90608117
37	response to acidic pH (GO:0010447)	4.86402583
38	regulation of autophagic vacuole assembly (GO:2000785)	4.84531352
39	androgen biosynthetic process (GO:0006702)	4.79837911
40	ventricular system development (GO:0021591)	4.71217977
41	protein polymerization (GO:0051258)	4.69454821
42	coenzyme catabolic process (GO:0009109)	4.68756289
43	tongue development (GO:0043586)	4.67624751
44	glutamine family amino acid catabolic process (GO:0009065)	4.62430401
45	cilium movement (GO:0003341)	4.62135068
46	cellular biogenic amine biosynthetic process (GO:0042401)	4.52638834
47	histone exchange (GO:0043486)	4.52486533
48	positive regulation of glycolytic process (GO:0045821)	4.52227775
49	regulation of synaptic transmission, dopaminergic (GO:0032225)	4.49684630
50	mitochondrion degradation (GO:0000422)	4.47506447
51	amine biosynthetic process (GO:0009309)	4.44916156
52	fusion of sperm to egg plasma membrane (GO:0007342)	4.40990774
53	calcium ion-dependent exocytosis (GO:0017156)	4.33903554
54	oogenesis (GO:0048477)	4.24497144
55	membrane repolarization during action potential (GO:0086011)	4.22386674
56	chromosome organization involved in meiosis (GO:0070192)	4.15897970
57	negative regulation of smooth muscle contraction (GO:0045986)	4.04776954
58	polyamine metabolic process (GO:0006595)	4.04596781
59	acrosome assembly (GO:0001675)	4.00022052
60	cellular process involved in reproduction in multicellular organism (GO:0022412)	3.95410253
61	regulation of vacuole organization (GO:0044088)	3.95060207
62	tryptophan catabolic process (GO:0006569)	3.91529343
63	indole-containing compound catabolic process (GO:0042436)	3.91529343
64	indolalkylamine catabolic process (GO:0046218)	3.91529343
65	meiotic nuclear division (GO:0007126)	3.89592694
66	positive regulation of amine transport (GO:0051954)	3.88307563
67	DNA double-strand break processing (GO:0000729)	3.82247455
68	aspartate family amino acid catabolic process (GO:0009068)	3.75818240
69	fertilization (GO:0009566)	3.74593066
70	diacylglycerol metabolic process (GO:0046339)	3.67196803
71	membrane repolarization (GO:0086009)	3.67191362
72	regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)	3.62296236
73	negative regulation of inclusion body assembly (GO:0090084)	3.60739231
74	piRNA metabolic process (GO:0034587)	3.53380382
75	negative regulation of JNK cascade (GO:0046329)	3.53237833
76	phosphatidylethanolamine biosynthetic process (GO:0006646)	3.52630264
77	potassium ion import (GO:0010107)	3.49011703
78	oligosaccharide biosynthetic process (GO:0009312)	3.48653767
79	plasma membrane fusion (GO:0045026)	3.47848132
80	cellular response to pH (GO:0071467)	3.47045531
81	cellular response to toxic substance (GO:0097237)	3.43407736
82	dicarboxylic acid biosynthetic process (GO:0043650)	3.40574432
83	negative regulation of reactive oxygen species metabolic process (GO:2000378)	3.35099624
84	negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway (GO:1902176)	3.31939659
85	detection of chemical stimulus involved in sensory perception of smell (GO:0050911)	3.23249873
86	negative regulation of striated muscle cell apoptotic process (GO:0010664)	3.21044892
87	phosphatidylethanolamine metabolic process (GO:0046337)	3.19090879
88	regulation of synaptic vesicle transport (GO:1902803)	3.14029970
89	synaptonemal complex assembly (GO:0007130)	3.10819805
90	spermatogenesis (GO:0007283)	3.05321407
91	DNA methylation involved in gamete generation (GO:0043046)	3.05137752
92	tryptophan metabolic process (GO:0006568)	3.04012151
93	male gamete generation (GO:0048232)	3.03976765
94	negative regulation of stress-activated MAPK cascade (GO:0032873)	3.02765644
95	negative regulation of stress-activated protein kinase signaling cascade (GO:0070303)	3.02765644
96	relaxation of muscle (GO:0090075)	3.00529834
97	cranial nerve morphogenesis (GO:0021602)	2.98004794
98	dicarboxylic acid catabolic process (GO:0043649)	2.96623974
99	positive regulation of synaptic transmission, dopaminergic (GO:0032226)	11.2765109
100	positive regulation of catecholamine secretion (GO:0033605)	10.0099547

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	BP1_19119308_ChIP-ChIP_Hs578T_Human	9.61232516
2	IGF1R_20145208_ChIP-Seq_DFB_Human	4.77738691
3	ESR1_20079471_ChIP-ChIP_T-47D_Human	3.57640198
4	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	3.13719714
5	EZH2_22144423_ChIP-Seq_EOC_Human	3.11210815
6	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.74960026
7	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	2.65927251
8	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.27948810
9	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	2.27948810
10	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.27316012
11	* CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.12028526
12	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	2.07083250
13	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	10.0492274
14	GBX2_23144817_ChIP-Seq_PC3_Human	1.92431777
15	AR_21572438_ChIP-Seq_LNCaP_Human	1.89749756
16	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.87544404
17	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.77337608
18	AHR_22903824_ChIP-Seq_MCF-7_Human	1.71942863
19	* NANOG_20526341_ChIP-Seq_ESCs_Human	1.64296509
20	CBP_20019798_ChIP-Seq_JUKART_Human	1.59122039
21	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.59122039
22	ER_23166858_ChIP-Seq_MCF-7_Human	1.58957779
23	RAC3_21632823_ChIP-Seq_H3396_Human	1.57737510
24	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.55949778
25	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.53980248
26	ERA_21632823_ChIP-Seq_H3396_Human	1.52447771
27	* FUS_26573619_Chip-Seq_HEK293_Human	1.52141640
28	OCT1_27270436_Chip-Seq_PROSTATE_Human	1.48388935
29	CTCF_27219007_Chip-Seq_Bcells_Human	1.47853669
30	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.46129011
31	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.42349758
32	VDR_22108803_ChIP-Seq_LS180_Human	1.38898553
33	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.38748699
34	MYC_19829295_ChIP-Seq_ESCs_Human	1.34611253
35	BCAT_22108803_ChIP-Seq_LS180_Human	1.33353483
36	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.33263402
37	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.31866229
38	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.28499906
39	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.26812831
40	TBL1_22424771_ChIP-Seq_293T_Human	1.24988889
41	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.24632055
42	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.19167439
43	* OCT4_20526341_ChIP-Seq_ESCs_Human	1.19143485
44	RUNX2_22187159_ChIP-Seq_PCA_Human	1.16720398
45	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.15809957
46	TP53_18474530_ChIP-ChIP_U2OS_Human	1.15766979
47	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.15483227
48	SMC4_20622854_ChIP-Seq_HELA_Human	1.15242144
49	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.10891602
50	IRF1_19129219_ChIP-ChIP_H3396_Human	1.09597321
51	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.08504059
52	SMAD4_21799915_ChIP-Seq_A2780_Human	1.08468726
53	CTCF_20526341_ChIP-Seq_ESCs_Human	1.08451573
54	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.06818595
55	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.05772515
56	ZNF274_21170338_ChIP-Seq_K562_Hela	1.05678888
57	* P300_19829295_ChIP-Seq_ESCs_Human	1.04672012
58	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.04163458
59	AR_21909140_ChIP-Seq_LNCAP_Human	1.02923942
60	SPI1_20517297_ChIP-Seq_HL60_Human	1.02317802
61	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.02288094
62	GATA1_22025678_ChIP-Seq_K562_Human	1.01362246
63	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.99489112
64	P53_22127205_ChIP-Seq_FIBROBLAST_Human	0.98476773
65	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	0.97349221
66	HOXB7_26014856_ChIP-Seq_BT474_Human	0.97066355
67	CBX2_27304074_Chip-Seq_ESCs_Mouse	0.93568415
68	MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human	0.93565505
69	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	0.93410771
70	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.93061156
71	P300_27268052_Chip-Seq_Bcells_Human	0.91951519
72	GATA3_21878914_ChIP-Seq_MCF-7_Human	0.91318461
73	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.90330031
74	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	0.90111906
75	VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human	0.90015665
76	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	0.89496837
77	RXR_22108803_ChIP-Seq_LS180_Human	0.89487125
78	* ERG_20517297_ChIP-Seq_VCAP_Human	0.88994077
79	P63_20808887_ChIP-Seq_KERATINOCYTES_Human	0.88895164
80	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.88890101
81	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.87801111
82	RAD21_21589869_ChIP-Seq_MESCs_Mouse	0.85551952
83	EZH2_27294783_Chip-Seq_ESCs_Mouse	0.85032704
84	PKCTHETA_26484144_Chip-Seq_BREAST_Human	0.84807119
85	STAT3_23295773_ChIP-Seq_U87_Human	0.83598983
86	IRF8_21731497_ChIP-ChIP_J774_Mouse	0.83476453
87	* SOX2_19829295_ChIP-Seq_ESCs_Human	0.82571178
88	* NANOG_19829295_ChIP-Seq_ESCs_Human	0.82571178
89	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	0.82008203
90	RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.81622847
91	TFAP2A_17053090_ChIP-ChIP_MCF-7_Human	0.81011289
92	PHF8_20622854_ChIP-Seq_HELA_Human	0.80723733
93	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	0.80618026
94	E2F1_17053090_ChIP-ChIP_MCF-7_Human	0.80433572
95	NFYB_21822215_ChIP-Seq_K562_Human	0.80336797
96	TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human	0.80239899
97	* AR_25329375_ChIP-Seq_VCAP_Human	0.80158489
98	MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	0.79810296
99	TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human	0.78960041
100	P68_20966046_ChIP-Seq_HELA_Human	0.77947795

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005410_abnormal_fertilization	8.91126924
2	MP0003315_abnormal_perineum_morphology	6.74253984
3	MP0008004_abnormal_stomach_pH	6.55598037
4	MP0005360_urolithiasis	3.95157617
5	MP0002160_abnormal_reproductive_system	3.78969451
6	MP0003698_abnormal_male_reproductive	3.16106188
7	MP0003045_fibrosis	2.92277364
8	MP0001929_abnormal_gametogenesis	2.80913564
9	MP0002132_abnormal_respiratory_system	2.48193106
10	MP0003136_yellow_coat_color	2.46925250
11	MP0001984_abnormal_olfaction	2.42405523
12	MP0000537_abnormal_urethra_morphology	2.38298490
13	MP0005058_abnormal_lysosome_morphology	2.34223536
14	MP0005187_abnormal_penis_morphology	2.19442951
15	MP0005394_taste/olfaction_phenotype	2.15433184
16	MP0005499_abnormal_olfactory_system	2.15433184
17	MP0005647_abnormal_sex_gland	2.15147773
18	MP0001664_abnormal_digestion	2.09683221
19	MP0010386_abnormal_urinary_bladder	2.06206467
20	MP0010368_abnormal_lymphatic_system	2.04951572
21	MP0001188_hyperpigmentation	1.89750997
22	MP0005389_reproductive_system_phenotype	1.86213080
23	MP0001905_abnormal_dopamine_level	1.81113596
24	MP0000538_abnormal_urinary_bladder	1.66017358
25	MP0002210_abnormal_sex_determination	1.63967384
26	MP0002161_abnormal_fertility/fecundity	1.59639575
27	MP0001145_abnormal_male_reproductive	1.49394225
28	MP0008995_early_reproductive_senescence	1.44950318
29	MP0006072_abnormal_retinal_apoptosis	1.42883002
30	MP0006036_abnormal_mitochondrial_physio	1.34853964
31	MP0000653_abnormal_sex_gland	1.33063244
32	MP0005646_abnormal_pituitary_gland	1.28109101
33	MP0002249_abnormal_larynx_morphology	1.27286577
34	MP0001501_abnormal_sleep_pattern	1.24994200
35	MP0000465_gastrointestinal_hemorrhage	1.19502005
36	MP0000678_abnormal_parathyroid_gland	1.16227571
37	MP0009697_abnormal_copulation	1.15973656
38	MP0003879_abnormal_hair_cell	1.14249257
39	MP0003632_abnormal_nervous_system	1.06345847
40	MP0001919_abnormal_reproductive_system	1.05964789
41	MP0003718_maternal_effect	1.05632546
42	MP0002127_abnormal_cardiovascular_syste	1.03909658
43	MP0001849_ear_inflammation	1.02763601
44	MP0000049_abnormal_middle_ear	1.00022792
45	MP0000343_altered_response_to	0.97994190
46	MP0000470_abnormal_stomach_morphology	0.96536495
47	MP0004085_abnormal_heartbeat	0.95016872
48	MP0008789_abnormal_olfactory_epithelium	0.94505973
49	MP0005395_other_phenotype	0.93900600
50	MP0003936_abnormal_reproductive_system	0.91409832
51	MP0002102_abnormal_ear_morphology	0.88491554
52	MP0002272_abnormal_nervous_system	0.88355949
53	MP0003631_nervous_system_phenotype	0.87479906
54	MP0004381_abnormal_hair_follicle	0.87037527
55	MP0002168_other_aberrant_phenotype	0.86145145
56	MP0003938_abnormal_ear_development	0.84220689
57	MP0000631_abnormal_neuroendocrine_gland	0.84117707
58	MP0002233_abnormal_nose_morphology	0.83970766
59	MP0001661_extended_life_span	0.83923338
60	MP0005253_abnormal_eye_physiology	0.83732699
61	MP0001529_abnormal_vocalization	0.80015406
62	MP0001485_abnormal_pinna_reflex	0.75166356
63	MP0001968_abnormal_touch/_nociception	0.74893861
64	MP0000230_abnormal_systemic_arterial	0.72960818
65	MP0001270_distended_abdomen	0.72267508
66	MP0001756_abnormal_urination	0.71169077
67	MP0004084_abnormal_cardiac_muscle	0.70647204
68	MP0005174_abnormal_tail_pigmentation	0.70424683
69	MP0003633_abnormal_nervous_system	0.67991776
70	MP0002090_abnormal_vision	0.67710145
71	MP0006276_abnormal_autonomic_nervous	0.66240797
72	MP0005551_abnormal_eye_electrophysiolog	0.65627487
73	MP0004272_abnormal_basement_membrane	0.65549463
74	MP0002277_abnormal_respiratory_mucosa	0.65246765
75	MP0005248_abnormal_Harderian_gland	0.62969673
76	MP0004036_abnormal_muscle_relaxation	0.62525688
77	MP0004885_abnormal_endolymph	0.60548476
78	MP0003806_abnormal_nucleotide_metabolis	0.60515130
79	MP0002138_abnormal_hepatobiliary_system	0.60120585
80	MP0002822_catalepsy	0.60076409
81	MP0003635_abnormal_synaptic_transmissio	0.60014187
82	MP0005620_abnormal_muscle_contractility	0.58745311
83	MP0009046_muscle_twitch	0.58580002
84	MP0001486_abnormal_startle_reflex	0.58281439
85	MP0000681_abnormal_thyroid_gland	0.56113542
86	MP0005377_hearing/vestibular/ear_phenot	0.54950106
87	MP0003878_abnormal_ear_physiology	0.54950106
88	MP0001764_abnormal_homeostasis	0.54829337
89	MP0005595_abnormal_vascular_smooth	0.52792361
90	MP0002752_abnormal_somatic_nervous	0.52546735
91	MP0009250_abnormal_appendicular_skeleto	0.51987086
92	MP0000026_abnormal_inner_ear	0.50515519
93	MP0001963_abnormal_hearing_physiology	0.50449447
94	MP0002638_abnormal_pupillary_reflex	0.50006380
95	MP0009745_abnormal_behavioral_response	0.47768775
96	MP0000762_abnormal_tongue_morphology	0.46391464
97	MP0005166_decreased_susceptibility_to	0.46165875
98	MP0005409_darkened_coat_color	0.45917403
99	MP0004859_abnormal_synaptic_plasticity	0.44914085
100	MP0001879_abnormal_lymphatic_vessel	0.42627579

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Hypoplasia of the uterus (HP:0000013)	7.70499102
2	Abnormal sex determination (HP:0012244)	7.56103399
3	Sex reversal (HP:0012245)	7.56103399
4	Resting tremor (HP:0002322)	6.91713092
5	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	6.17350608
6	Aplasia/hypoplasia of the uterus (HP:0008684)	5.86445086
7	Dynein arm defect of respiratory motile cilia (HP:0012255)	5.57964549
8	Absent/shortened dynein arms (HP:0200106)	5.57964549
9	Abnormality of the columella (HP:0009929)	5.44945144
10	Abnormal respiratory motile cilium physiology (HP:0012261)	5.44162266
11	Reduced antithrombin III activity (HP:0001976)	5.35586565
12	Gonadal dysgenesis (HP:0000133)	5.30292772
13	Abnormal ciliary motility (HP:0012262)	5.21976007
14	Male pseudohermaphroditism (HP:0000037)	4.84112478
15	Colitis (HP:0002583)	4.69094617
16	Ventricular fibrillation (HP:0001663)	4.66533145
17	Postural instability (HP:0002172)	4.55149822
18	Cerebellar dysplasia (HP:0007033)	4.48986594
19	Infertility (HP:0000789)	4.30606777
20	Type II lissencephaly (HP:0007260)	4.20113606
21	Abnormal respiratory motile cilium morphology (HP:0005938)	4.18833441
22	Abnormal respiratory epithelium morphology (HP:0012253)	4.18833441
23	Facial hemangioma (HP:0000329)	4.18425566
24	Germ cell neoplasia (HP:0100728)	3.96278069
25	Thoracic kyphosis (HP:0002942)	3.67789852
26	Thoracolumbar scoliosis (HP:0002944)	3.48894671
27	Urinary urgency (HP:0000012)	3.41075089
28	Retinal dysplasia (HP:0007973)	3.33246947
29	Nasal polyposis (HP:0100582)	3.32252122
30	Self-mutilation (HP:0000742)	3.24841283
31	Abnormality of the intrinsic pathway (HP:0010989)	3.19195159
32	Rhinitis (HP:0012384)	3.13772165
33	Protruding tongue (HP:0010808)	3.07823540
34	Occipital encephalocele (HP:0002085)	3.05981337
35	Inflammation of the large intestine (HP:0002037)	3.04697168
36	Atonic seizures (HP:0010819)	3.02727289
37	Capillary hemangiomas (HP:0005306)	3.00854060
38	Retinal atrophy (HP:0001105)	2.95820325
39	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.91899651
40	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.91899651
41	Abnormality of the nasal mucosa (HP:0000433)	2.88846713
42	Hypothermia (HP:0002045)	2.81128072
43	Gastrointestinal inflammation (HP:0004386)	2.77053581
44	Inability to walk (HP:0002540)	2.74309165
45	Congenital sensorineural hearing impairment (HP:0008527)	2.67320921
46	Anterior segment dysgenesis (HP:0007700)	2.64718584
47	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.61083867
48	Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)	2.59782737
49	Sensory axonal neuropathy (HP:0003390)	2.59426174
50	Abnormality of the lumbar spine (HP:0100712)	2.53370777
51	Abnormality of male internal genitalia (HP:0000022)	2.46674033
52	Chronic bronchitis (HP:0004469)	2.42186957
53	Syncope (HP:0001279)	2.41626746
54	Prolonged QT interval (HP:0001657)	2.36260884
55	Abnormality of the thoracic spine (HP:0100711)	2.36187240
56	Absent thumb (HP:0009777)	2.29937622
57	Bronchiectasis (HP:0002110)	2.29739905
58	Unsteady gait (HP:0002317)	2.24845726
59	Buphthalmos (HP:0000557)	2.20515167
60	Abnormality of the frontal sinuses (HP:0002687)	2.15827386
61	Tubulointerstitial nephritis (HP:0001970)	2.11541597
62	Absent speech (HP:0001344)	2.08706819
63	Renal dysplasia (HP:0000110)	2.07670788
64	Aplasia/Hypoplasia involving the sinuses (HP:0009120)	2.07118961
65	Chronic sinusitis (HP:0011109)	2.02522359
66	Abnormal protein glycosylation (HP:0012346)	1.99596516
67	Abnormal glycosylation (HP:0012345)	1.99596516
68	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.99596516
69	Abnormal protein N-linked glycosylation (HP:0012347)	1.99596516
70	Polydipsia (HP:0001959)	1.97674178
71	Abnormal drinking behavior (HP:0030082)	1.97674178
72	Optic nerve hypoplasia (HP:0000609)	1.96989491
73	Abnormality of the ileum (HP:0001549)	1.91813238
74	Facial diplegia (HP:0001349)	1.88373909
75	Polyneuropathy (HP:0001271)	1.86328436
76	Spinal rigidity (HP:0003306)	1.83137124
77	Abnormal rod and cone electroretinograms (HP:0008323)	1.82823753
78	Decreased number of peripheral myelinated nerve fibers (HP:0003380)	1.80585141
79	True hermaphroditism (HP:0010459)	1.80353456
80	Anencephaly (HP:0002323)	1.76524574
81	Intellectual disability, progressive (HP:0006887)	1.75076417
82	Enlarged kidneys (HP:0000105)	1.74017049
83	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.72406726
84	Atrial fibrillation (HP:0005110)	1.68182469
85	High anterior hairline (HP:0009890)	1.65502561
86	Abnormality of long-chain fatty-acid metabolism (HP:0010964)	1.62833815
87	Aplasia cutis congenita (HP:0001057)	1.62396485
88	Median cleft lip (HP:0000161)	1.61697767
89	Meckel diverticulum (HP:0002245)	1.60366865
90	Abnormality of the vitreous humor (HP:0004327)	1.59937902
91	Bradykinesia (HP:0002067)	1.59659752
92	Cystic liver disease (HP:0006706)	1.58823475
93	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.58522779
94	Coxa valga (HP:0002673)	1.57117744
95	Anxiety (HP:0000739)	1.57068743
96	Abnormality of cochlea (HP:0000375)	1.55598759
97	Abnormality of macular pigmentation (HP:0008002)	1.54937596
98	Abnormal EKG (HP:0003115)	1.54624319
99	Depression (HP:0000716)	1.54555623
100	Congenital malformation of the right heart (HP:0011723)	1.53448951

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	MARK3	6.15944698
2	TLK1	5.16545679
3	ZAK	4.18849333
4	MYLK	3.10177535
5	RPS6KA5	2.90257829
6	NEK2	2.17088967
7	PINK1	11.5478565
8	FRK	1.94004194
9	LATS1	1.93776433
10	STK38	1.50271641
11	MAP2K7	1.42066731
12	STK38L	1.21618693
13	CSNK1A1L	1.18768155
14	CSNK1G3	1.08417071
15	CDK3	1.08360266
16	VRK1	1.06602143
17	SGK223	1.05609518
18	SGK494	1.05609518
19	ADRBK2	1.02697631
20	DYRK3	0.92892867
21	LATS2	0.87879110
22	CSNK1G2	0.84204707
23	CSNK1G1	0.84004976
24	MAP3K9	0.83837305
25	PRKCQ	0.83493462
26	ARAF	0.79779928
27	MAPK15	0.79185095
28	MST1R	0.77945276
29	BMPR1B	0.77322989
30	CDK14	0.74480050
31	MELK	0.72456153
32	OBSCN	0.68322394
33	CDC42BPA	0.67596494
34	TIE1	0.65899628
35	DYRK2	0.64662157
36	PRKD3	0.58980941
37	DAPK3	0.57887754
38	FGR	0.55156701
39	MAP3K13	0.50094809
40	MAP3K1	0.49614485
41	GRK5	0.47989575
42	PKN1	0.47342440
43	NME2	0.46561182
44	CAMK1	0.46299091
45	PAK1	0.45736598
46	CDK5	0.44580836
47	MAP3K5	0.43895440
48	PLK4	0.41813693
49	PTK2B	0.38065132
50	GRK6	0.37485308
51	FGFR2	0.37405481
52	PRKG2	0.36727464
53	MAP3K10	0.36177172
54	GRK1	0.35342171
55	ATM	0.35088882
56	TGFBR1	0.34719368
57	ROCK1	0.34195095
58	EGFR	0.31880021
59	ILK	0.31366441
60	RPS6KB1	0.31165441
61	PRKG1	0.30932592
62	PDPK1	0.30817277
63	SGK2	0.30611601
64	MOS	0.30189117
65	CSNK1A1	0.28345567
66	RET	0.27575877
67	PAK2	0.27557140
68	EIF2AK3	0.23824225
69	PDK1	0.23135574
70	RPS6KA1	0.22724880
71	BRAF	0.22393131
72	STK3	0.21217630
73	IRAK2	0.21211419
74	CDK8	0.20690439
75	FES	0.17495543
76	AKT2	0.16562265
77	RPS6KA3	0.16012418
78	ICK	0.15696860
79	MAPK12	0.15528854
80	AURKB	0.15340590
81	PLK1	0.15079953
82	TAF1	0.14918438
83	AURKA	0.12543433
84	CSNK1D	0.11711147
85	MAPK1	0.11502591
86	MAPK11	0.08969958
87	RPS6KA4	0.07868428
88	INSRR	0.07640710
89	STK4	0.07290373
90	WNK3	0.07145362
91	BTK	0.06673127
92	TXK	0.05739127
93	SIK2	0.05332794
94	CSNK2A1	0.05234040
95	MAPKAPK5	0.04119819
96	WNK1	0.03974760
97	TYRO3	0.03832356
98	CAMK1G	0.03491077
99	MTOR	0.02381235
100	PIM1	0.02142046

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	7.92233517
2	Gap junction_Homo sapiens_hsa04540	5.29935351
3	Systemic lupus erythematosus_Homo sapiens_hsa05322	3.85144418
4	Hedgehog signaling pathway_Homo sapiens_hsa04340	3.69397776
5	Nitrogen metabolism_Homo sapiens_hsa00910	3.63946770
6	Phagosome_Homo sapiens_hsa04145	2.98329465
7	Apoptosis_Homo sapiens_hsa04210	2.94772754
8	Alcoholism_Homo sapiens_hsa05034	2.78631313
9	Olfactory transduction_Homo sapiens_hsa04740	2.51533977
10	Arginine biosynthesis_Homo sapiens_hsa00220	2.31106103
11	Propanoate metabolism_Homo sapiens_hsa00640	2.26079483
12	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.97280767
13	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	1.96034214
14	Butanoate metabolism_Homo sapiens_hsa00650	1.75685443
15	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.49216229
16	Pyruvate metabolism_Homo sapiens_hsa00620	1.48393868
17	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.46595880
18	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.42947356
19	Glutathione metabolism_Homo sapiens_hsa00480	1.42662339
20	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.28811303
21	Sulfur relay system_Homo sapiens_hsa04122	1.23568825
22	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.15837635
23	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.13842919
24	Chemical carcinogenesis_Homo sapiens_hsa05204	1.01323942
25	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.99288533
26	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.96112718
27	Taste transduction_Homo sapiens_hsa04742	0.94817103
28	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.91620754
29	Tryptophan metabolism_Homo sapiens_hsa00380	0.89143284
30	Oocyte meiosis_Homo sapiens_hsa04114	0.86786284
31	Glucagon signaling pathway_Homo sapiens_hsa04922	0.83477200
32	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.76798599
33	Renin secretion_Homo sapiens_hsa04924	0.76222634
34	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.76088311
35	Basal transcription factors_Homo sapiens_hsa03022	0.75137071
36	Phenylalanine metabolism_Homo sapiens_hsa00360	0.74938688
37	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.74070752
38	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.72819775
39	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.72782498
40	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.70524523
41	Fanconi anemia pathway_Homo sapiens_hsa03460	0.69858918
42	Phototransduction_Homo sapiens_hsa04744	0.69140215
43	beta-Alanine metabolism_Homo sapiens_hsa00410	0.66086503
44	Circadian rhythm_Homo sapiens_hsa04710	0.66002657
45	PPAR signaling pathway_Homo sapiens_hsa03320	0.65603369
46	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.65313204
47	Fatty acid degradation_Homo sapiens_hsa00071	0.61431820
48	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.61410147
49	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.60877385
50	Purine metabolism_Homo sapiens_hsa00230	0.58984606
51	Pentose phosphate pathway_Homo sapiens_hsa00030	0.57935494
52	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.55829294
53	Gastric acid secretion_Homo sapiens_hsa04971	0.55565447
54	mRNA surveillance pathway_Homo sapiens_hsa03015	0.51495728
55	Circadian entrainment_Homo sapiens_hsa04713	0.50031886
56	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.49703495
57	Calcium signaling pathway_Homo sapiens_hsa04020	0.45467947
58	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.44788309
59	Wnt signaling pathway_Homo sapiens_hsa04310	0.40784648
60	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.40559622
61	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.40264928
62	RNA degradation_Homo sapiens_hsa03018	0.37909657
63	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.35895523
64	Tyrosine metabolism_Homo sapiens_hsa00350	0.34965113
65	Metabolic pathways_Homo sapiens_hsa01100	0.32088465
66	Regulation of autophagy_Homo sapiens_hsa04140	0.26598886
67	Parkinsons disease_Homo sapiens_hsa05012	0.25633050
68	Selenocompound metabolism_Homo sapiens_hsa00450	0.22561322
69	GABAergic synapse_Homo sapiens_hsa04727	0.21506026
70	Retinol metabolism_Homo sapiens_hsa00830	0.20009400
71	RNA transport_Homo sapiens_hsa03013	0.19448981
72	Arginine and proline metabolism_Homo sapiens_hsa00330	0.18493165
73	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.18155170
74	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.18010559
75	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.17741962
76	Nicotine addiction_Homo sapiens_hsa05033	0.17666800
77	Peroxisome_Homo sapiens_hsa04146	0.17479815
78	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.16607974
79	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.16307287
80	Glycerolipid metabolism_Homo sapiens_hsa00561	0.15634088
81	Choline metabolism in cancer_Homo sapiens_hsa05231	0.15409215
82	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.14503505
83	Herpes simplex infection_Homo sapiens_hsa05168	0.13284128
84	Glutamatergic synapse_Homo sapiens_hsa04724	0.12946785
85	Salivary secretion_Homo sapiens_hsa04970	0.12810324
86	Viral carcinogenesis_Homo sapiens_hsa05203	0.12524200
87	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	0.12451802
88	Fatty acid metabolism_Homo sapiens_hsa01212	0.12080990
89	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.11706506
90	Graft-versus-host disease_Homo sapiens_hsa05332	0.11299656
91	Morphine addiction_Homo sapiens_hsa05032	0.11113840
92	MAPK signaling pathway_Homo sapiens_hsa04010	0.10420935
93	Estrogen signaling pathway_Homo sapiens_hsa04915	0.10295217
94	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.09091141
95	Amphetamine addiction_Homo sapiens_hsa05031	0.08841217
96	Sphingolipid metabolism_Homo sapiens_hsa00600	0.07094122
97	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.06638817
98	Endometrial cancer_Homo sapiens_hsa05213	0.06474953
99	Long-term potentiation_Homo sapiens_hsa04720	0.05832301
100	B cell receptor signaling pathway_Homo sapiens_hsa04662	0.05668918

PPP1R2P3

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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