PPP1R2P6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1opioid receptor signaling pathway (GO:0038003)9.54668149
2negative regulation of cAMP-mediated signaling (GO:0043951)7.90420996
3negative regulation of calcium ion-dependent exocytosis (GO:0045955)7.16658559
4behavioral response to ethanol (GO:0048149)6.89772150
5ether lipid metabolic process (GO:0046485)6.82974853
6adult feeding behavior (GO:0008343)6.14020618
7regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)6.11959994
8regulation of translational termination (GO:0006449)5.99455431
9regulation of protein polyubiquitination (GO:1902914)5.79789158
10positive regulation of cAMP-mediated signaling (GO:0043950)5.60122103
11cornea development in camera-type eye (GO:0061303)5.51831763
12regulation of acrosome reaction (GO:0060046)5.46103532
13negative regulation of nitric oxide biosynthetic process (GO:0045019)5.02445528
14adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)4.98714448
15DNA deamination (GO:0045006)4.95010295
16regulation of protein glycosylation (GO:0060049)4.80831019
17thrombin receptor signaling pathway (GO:0070493)4.48566779
18cAMP catabolic process (GO:0006198)4.46429528
19cellular ketone body metabolic process (GO:0046950)4.44642742
20positive regulation of fatty acid beta-oxidation (GO:0032000)4.35303382
21sphingosine metabolic process (GO:0006670)4.23145522
22piRNA metabolic process (GO:0034587)4.08368397
23diol metabolic process (GO:0034311)4.06352658
24glycerophospholipid catabolic process (GO:0046475)3.91910666
25ketone body metabolic process (GO:1902224)3.89555960
26cyclic nucleotide catabolic process (GO:0009214)3.87181224
27sphingoid metabolic process (GO:0046519)3.69592668
28regulation of cAMP-mediated signaling (GO:0043949)3.66789730
29notochord development (GO:0030903)3.62336621
30cellular response to ammonium ion (GO:0071242)3.55227698
31negative regulation of glycoprotein biosynthetic process (GO:0010561)3.54559568
32negative regulation of reactive oxygen species metabolic process (GO:2000378)3.53793262
33response to gravity (GO:0009629)3.49804168
34phosphatidylinositol acyl-chain remodeling (GO:0036149)3.46940275
35regulation of triglyceride catabolic process (GO:0010896)3.45835956
36iron ion import (GO:0097286)3.41035696
37positive regulation of fatty acid oxidation (GO:0046321)3.38543143
38regulation of glutamate receptor signaling pathway (GO:1900449)3.37485368
39negative regulation by host of viral transcription (GO:0043922)3.36743270
40purine ribonucleoside bisphosphate metabolic process (GO:0034035)3.26847373
413-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)3.26847373
42mRNA cleavage (GO:0006379)3.23850174
43cellular response to alkaloid (GO:0071312)3.23071164
44positive regulation of triglyceride biosynthetic process (GO:0010867)3.13943926
45signal complex assembly (GO:0007172)3.11716785
46cellular response to ATP (GO:0071318)3.10925120
47regulation of triglyceride biosynthetic process (GO:0010866)3.08092735
48response to morphine (GO:0043278)3.07620752
49DNA replication-dependent nucleosome assembly (GO:0006335)3.07085358
50DNA replication-dependent nucleosome organization (GO:0034723)3.07085358
51replication fork processing (GO:0031297)3.06940117
52phosphorelay signal transduction system (GO:0000160)3.05011669
53histone H4-K8 acetylation (GO:0043982)3.02345695
54histone H4-K5 acetylation (GO:0043981)3.02345695
55vascular smooth muscle contraction (GO:0014829)2.99642902
56glycerol ether metabolic process (GO:0006662)2.98932519
57response to isoquinoline alkaloid (GO:0014072)2.95526380
58artery smooth muscle contraction (GO:0014824)2.95174053
59behavioral response to nicotine (GO:0035095)2.95151280
60lung secretory cell differentiation (GO:0061140)2.92870908
61cysteine metabolic process (GO:0006534)2.90660428
62positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.89229286
63gamma-aminobutyric acid transport (GO:0015812)2.88229408
64regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.87578805
65omega-hydroxylase P450 pathway (GO:0097267)2.81959872
66negative regulation of actin filament bundle assembly (GO:0032232)2.81073425
67fat-soluble vitamin catabolic process (GO:0042363)2.80406488
68vitamin catabolic process (GO:0009111)2.80406488
69retinal cone cell development (GO:0046549)2.78843161
70negative regulation of cell aging (GO:0090344)2.78632896
71indole-containing compound catabolic process (GO:0042436)2.78576955
72indolalkylamine catabolic process (GO:0046218)2.78576955
73tryptophan catabolic process (GO:0006569)2.78576955
74negative regulation of cAMP biosynthetic process (GO:0030818)2.76247725
75regulation of sequestering of triglyceride (GO:0010889)2.76109282
76ether metabolic process (GO:0018904)2.74909694
77positive regulation of T cell mediated cytotoxicity (GO:0001916)2.71710905
78lung epithelial cell differentiation (GO:0060487)2.70438289
79regulation of T cell mediated cytotoxicity (GO:0001914)2.70280096
80negative regulation of adenylate cyclase activity (GO:0007194)2.68673218
81dopamine transport (GO:0015872)2.67998023
82mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.66088092
83mitochondrial respiratory chain complex I assembly (GO:0032981)2.66088092
84NADH dehydrogenase complex assembly (GO:0010257)2.66088092
85regulation of relaxation of muscle (GO:1901077)2.65517604
86regulation of odontogenesis (GO:0042481)2.65197405
87epoxygenase P450 pathway (GO:0019373)2.65183598
88negative regulation of cyclic nucleotide biosynthetic process (GO:0030803)2.64451396
89ncRNA catabolic process (GO:0034661)2.64408409
90RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.63370795
91glomerular filtration (GO:0003094)2.62818329
92viral mRNA export from host cell nucleus (GO:0046784)2.62672522
93establishment of tissue polarity (GO:0007164)2.62036705
94establishment of planar polarity (GO:0001736)2.62036705
95transmission of nerve impulse (GO:0019226)2.61860776
96regulation of rhodopsin mediated signaling pathway (GO:0022400)2.60785555
97regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.60008090
98response to epinephrine (GO:0071871)2.57669601
99positive regulation of defense response to virus by host (GO:0002230)2.56450219
100negative regulation of cytosolic calcium ion concentration (GO:0051481)10.3603764

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human5.56464990
2GLI1_17442700_ChIP-ChIP_MESCs_Mouse5.07042000
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.04845680
4BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.98104075
5VDR_22108803_ChIP-Seq_LS180_Human3.83045251
6ZNF274_21170338_ChIP-Seq_K562_Hela3.15689673
7RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.89766528
8POU5F1_26923725_Chip-Seq_MESODERM_Mouse2.48691536
9TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.48691536
10FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.26285876
11FLI1_27457419_Chip-Seq_LIVER_Mouse2.02340249
12ZFP57_27257070_Chip-Seq_ESCs_Mouse1.90928890
13PCGF2_27294783_Chip-Seq_ESCs_Mouse1.90083879
14GBX2_23144817_ChIP-Seq_PC3_Human1.88907937
15BCAT_22108803_ChIP-Seq_LS180_Human1.87484391
16TAF15_26573619_Chip-Seq_HEK293_Human1.73636456
17CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.72356221
18STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.70806194
19PCGF2_27294783_Chip-Seq_NPCs_Mouse1.62656504
20RXR_22108803_ChIP-Seq_LS180_Human1.61105635
21NANOG_20526341_ChIP-Seq_ESCs_Human1.56552647
22NANOG_19829295_ChIP-Seq_ESCs_Human1.55464596
23SOX2_19829295_ChIP-Seq_ESCs_Human1.55464596
24EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.53758095
25SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.53287616
26ER_23166858_ChIP-Seq_MCF-7_Human1.47307409
27E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.44460858
28CBP_20019798_ChIP-Seq_JUKART_Human1.43982795
29IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.43982795
30CTBP2_25329375_ChIP-Seq_LNCAP_Human1.43222632
31GATA3_21878914_ChIP-Seq_MCF-7_Human1.42976746
32EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.42735160
33TP53_22573176_ChIP-Seq_HFKS_Human1.41649184
34NOTCH1_21737748_ChIP-Seq_TLL_Human1.38472123
35STAT3_23295773_ChIP-Seq_U87_Human1.37937847
36SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.37864846
37SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.36273609
38TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.34259226
39DROSHA_22980978_ChIP-Seq_HELA_Human1.32743518
40CTBP1_25329375_ChIP-Seq_LNCAP_Human1.32314002
41TCF4_23295773_ChIP-Seq_U87_Human1.30697242
42CDX2_22108803_ChIP-Seq_LS180_Human1.29588222
43PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.28394395
44POU3F2_20337985_ChIP-ChIP_501MEL_Human1.27534308
45SMAD3_21741376_ChIP-Seq_EPCs_Human1.26238301
46FLI1_21867929_ChIP-Seq_TH2_Mouse1.25018090
47AR_21572438_ChIP-Seq_LNCaP_Human1.23987261
48CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22321071
49SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.22249764
50IRF1_19129219_ChIP-ChIP_H3396_Human1.21578835
51AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.21341317
52BMI1_23680149_ChIP-Seq_NPCS_Mouse1.20920533
53BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.20827905
54VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.20065750
55JARID2_20064375_ChIP-Seq_MESCs_Mouse1.19626337
56SUZ12_27294783_Chip-Seq_NPCs_Mouse1.19399207
57MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.19062052
58PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.18503044
59MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.18246440
60PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.16208511
61FUS_26573619_Chip-Seq_HEK293_Human1.15950162
62AR_20517297_ChIP-Seq_VCAP_Human1.15013063
63UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.14852837
64FOXA1_27270436_Chip-Seq_PROSTATE_Human1.14691153
65FOXA1_25329375_ChIP-Seq_VCAP_Human1.14691153
66NFE2_27457419_Chip-Seq_LIVER_Mouse1.13184512
67P300_19829295_ChIP-Seq_ESCs_Human1.09725868
68FOXH1_21741376_ChIP-Seq_EPCs_Human1.09415171
69FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.08596175
70SMAD4_21799915_ChIP-Seq_A2780_Human1.08586358
71SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.07635838
72EZH2_27304074_Chip-Seq_ESCs_Mouse1.05956103
73PIAS1_25552417_ChIP-Seq_VCAP_Human1.05169229
74ESR1_20079471_ChIP-ChIP_T-47D_Human1.04522580
75TAF2_19829295_ChIP-Seq_ESCs_Human1.04144628
76HOXB7_26014856_ChIP-Seq_BT474_Human1.04085437
77TDRD3_21172665_ChIP-Seq_MCF-7_Human1.03993524
78EZH2_22144423_ChIP-Seq_EOC_Human1.03516319
79TOP2B_26459242_ChIP-Seq_MCF-7_Human1.03097173
80FOXH1_21741376_ChIP-Seq_ESCs_Human1.02962450
81RUNX2_22187159_ChIP-Seq_PCA_Human1.02750030
82EZH2_27294783_Chip-Seq_ESCs_Mouse1.02192577
83GATA3_21867929_ChIP-Seq_TH1_Mouse1.01618526
84AR_25329375_ChIP-Seq_VCAP_Human1.00968221
85NR3C1_21868756_ChIP-Seq_MCF10A_Human1.00351028
86SMAD3_21741376_ChIP-Seq_HESCs_Human1.00230202
87SMAD4_21741376_ChIP-Seq_EPCs_Human0.99173891
88KDM2B_26808549_Chip-Seq_REH_Human0.98201865
89REST_21632747_ChIP-Seq_MESCs_Mouse0.98124633
90EGR1_23403033_ChIP-Seq_LIVER_Mouse0.97703705
91TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.97541226
92CBP_21632823_ChIP-Seq_H3396_Human0.96121748
93JARID2_20075857_ChIP-Seq_MESCs_Mouse0.95590600
94CBX2_27304074_Chip-Seq_ESCs_Mouse0.95057854
95HTT_18923047_ChIP-ChIP_STHdh_Human0.94153125
96PRDM14_20953172_ChIP-Seq_ESCs_Human0.93979834
97SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.93938325
98RAC3_21632823_ChIP-Seq_H3396_Human0.93332341
99TCF4_22108803_ChIP-Seq_LS180_Human0.92303403
100EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.91012374

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009780_abnormal_chondrocyte_physiolo8.66327617
2MP0002876_abnormal_thyroid_physiology4.71352000
3MP0009278_abnormal_bone_marrow3.82833425
4MP0003283_abnormal_digestive_organ3.38055667
5MP0001968_abnormal_touch/_nociception3.02637988
6MP0001501_abnormal_sleep_pattern2.94256054
7MP0004147_increased_porphyrin_level2.79482730
8MP0005360_urolithiasis2.74272472
9MP0005503_abnormal_tendon_morphology2.36238107
10MP0009764_decreased_sensitivity_to2.30735519
11MP0000678_abnormal_parathyroid_gland2.29490860
12MP0002653_abnormal_ependyma_morphology2.26950329
13MP0001664_abnormal_digestion1.91448550
14MP0005551_abnormal_eye_electrophysiolog1.88100468
15MP0009333_abnormal_splenocyte_physiolog1.80261271
16MP0005645_abnormal_hypothalamus_physiol1.75666620
17MP0000230_abnormal_systemic_arterial1.75433902
18MP0003959_abnormal_lean_body1.68287304
19MP0009745_abnormal_behavioral_response1.65578003
20MP0003880_abnormal_central_pattern1.62400968
21MP0003183_abnormal_peptide_metabolism1.58404893
22MP0005167_abnormal_blood-brain_barrier1.58375459
23MP0005646_abnormal_pituitary_gland1.58105648
24MP0002249_abnormal_larynx_morphology1.52939895
25MP0003950_abnormal_plasma_membrane1.51513259
26MP0008872_abnormal_physiological_respon1.50144082
27MP0003879_abnormal_hair_cell1.45351548
28MP0003195_calcinosis1.45305654
29MP0002272_abnormal_nervous_system1.44646376
30MP0002733_abnormal_thermal_nociception1.44022124
31MP0003638_abnormal_response/metabolism_1.43017118
32MP0004145_abnormal_muscle_electrophysio1.42347203
33MP0000681_abnormal_thyroid_gland1.37594641
34MP0002009_preneoplasia1.36439874
35MP0009384_cardiac_valve_regurgitation1.34478599
36MP0003633_abnormal_nervous_system1.34149518
37MP0001986_abnormal_taste_sensitivity1.33260562
38MP0005397_hematopoietic_system_phenotyp1.31174960
39MP0001545_abnormal_hematopoietic_system1.31174960
40MP0001485_abnormal_pinna_reflex1.25779639
41MP0004742_abnormal_vestibular_system1.23831126
42MP0000462_abnormal_digestive_system1.18672363
43MP0008875_abnormal_xenobiotic_pharmacok1.14836865
44MP0005085_abnormal_gallbladder_physiolo1.13135941
45MP0000749_muscle_degeneration1.12495800
46MP0008775_abnormal_heart_ventricle1.12092371
47MP0001970_abnormal_pain_threshold1.10901701
48MP0005332_abnormal_amino_acid1.09496750
49MP0000049_abnormal_middle_ear1.06682686
50MP0000015_abnormal_ear_pigmentation1.04982109
51MP0004782_abnormal_surfactant_physiolog1.04552698
52MP0001533_abnormal_skeleton_physiology1.04439304
53MP0003045_fibrosis1.04436067
54MP0002148_abnormal_hypersensitivity_rea1.01139106
55MP0006035_abnormal_mitochondrial_morpho1.01092787
56MP0001881_abnormal_mammary_gland0.99010937
57MP0003941_abnormal_skin_development0.97886837
58MP0002796_impaired_skin_barrier0.95293227
59MP0008057_abnormal_DNA_replication0.93892970
60MP0001324_abnormal_eye_pigmentation0.90060181
61MP0002735_abnormal_chemical_nociception0.89531118
62MP0005390_skeleton_phenotype0.88844894
63MP0001486_abnormal_startle_reflex0.87822443
64MP0009643_abnormal_urine_homeostasis0.87675428
65MP0006072_abnormal_retinal_apoptosis0.85600307
66MP0009046_muscle_twitch0.84636864
67MP0003191_abnormal_cellular_cholesterol0.84110756
68MP0004130_abnormal_muscle_cell0.83814057
69MP0002693_abnormal_pancreas_physiology0.83806131
70MP0001270_distended_abdomen0.83794515
71MP0002837_dystrophic_cardiac_calcinosis0.83615579
72MP0004215_abnormal_myocardial_fiber0.82297913
73MP0005367_renal/urinary_system_phenotyp0.81627651
74MP0000516_abnormal_urinary_system0.81627651
75MP0003567_abnormal_fetal_cardiomyocyte0.79320272
76MP0001963_abnormal_hearing_physiology0.79110242
77MP0004484_altered_response_of0.77412151
78MP0002638_abnormal_pupillary_reflex0.75693925
79MP0003172_abnormal_lysosome_physiology0.74362610
80MP0002971_abnormal_brown_adipose0.73161768
81MP0005334_abnormal_fat_pad0.71944631
82MP0003646_muscle_fatigue0.70445746
83MP0002108_abnormal_muscle_morphology0.68791887
84MP0000427_abnormal_hair_cycle0.68597016
85MP0005253_abnormal_eye_physiology0.68032318
86MP0003631_nervous_system_phenotype0.67633098
87MP0001919_abnormal_reproductive_system0.66755445
88MP0005195_abnormal_posterior_eye0.66289410
89MP0004085_abnormal_heartbeat0.65736475
90MP0004142_abnormal_muscle_tone0.64544702
91MP0000538_abnormal_urinary_bladder0.63453914
92MP0005083_abnormal_biliary_tract0.63340808
93MP0002557_abnormal_social/conspecific_i0.62769520
94MP0000470_abnormal_stomach_morphology0.62045000
95MP0002254_reproductive_system_inflammat0.58587096
96MP0005620_abnormal_muscle_contractility0.57991098
97MP0001765_abnormal_ion_homeostasis0.56256147
98MP0002136_abnormal_kidney_physiology0.55113002
99MP0002572_abnormal_emotion/affect_behav0.53467540
100MP0009379_abnormal_foot_pigmentation0.53036498

Predicted human phenotypes

RankGene SetZ-score
1Intestinal atresia (HP:0011100)5.33191713
2Volvulus (HP:0002580)4.97573900
3Large for gestational age (HP:0001520)4.65303729
4Abnormality of pyruvate family amino acid metabolism (HP:0010915)4.47576657
5Abnormality of alanine metabolism (HP:0010916)4.47576657
6Hyperalaninemia (HP:0003348)4.47576657
73-Methylglutaconic aciduria (HP:0003535)4.20181292
8Poor head control (HP:0002421)4.06582090
9Abnormality of the aortic arch (HP:0012303)4.06118173
10Gaze-evoked nystagmus (HP:0000640)3.89745604
11Chorioretinal atrophy (HP:0000533)3.62831047
12Agitation (HP:0000713)3.46360282
13Thickened helices (HP:0000391)3.37695484
14Tubular atrophy (HP:0000092)3.33580466
15Large eyes (HP:0001090)3.25825700
16Pancreatic islet-cell hyperplasia (HP:0004510)3.17876833
17Keratoconus (HP:0000563)3.09760999
18Increased corneal curvature (HP:0100692)3.09760999
19Mesangial abnormality (HP:0001966)3.09723415
20Pendular nystagmus (HP:0012043)3.07112369
21Nonprogressive disorder (HP:0003680)2.96979237
22Fair hair (HP:0002286)2.88501804
23Broad alveolar ridges (HP:0000187)2.83754275
24Progressive inability to walk (HP:0002505)2.75925850
25Abolished electroretinogram (ERG) (HP:0000550)2.74331953
26Oligodontia (HP:0000677)2.70811021
27Posterior subcapsular cataract (HP:0007787)2.69750320
28Gastrointestinal atresia (HP:0002589)2.69684184
29Congenital stationary night blindness (HP:0007642)2.67803463
30Cerebellar dysplasia (HP:0007033)2.64876741
31Abnormality of the ileum (HP:0001549)2.59233273
32Hypomagnesemia (HP:0002917)2.57658889
33Hypoproteinemia (HP:0003075)2.46813954
34Pili torti (HP:0003777)2.44719046
35Decreased circulating renin level (HP:0003351)2.43496452
36Polydipsia (HP:0001959)2.37655116
37Abnormal drinking behavior (HP:0030082)2.37655116
38Abnormal hair laboratory examination (HP:0003328)2.36690764
39Generalized hypopigmentation of hair (HP:0011358)2.34938231
40Meningioma (HP:0002858)2.34419688
41Scotoma (HP:0000575)2.33931978
42Disproportionate short-trunk short stature (HP:0003521)2.32607825
43Type II lissencephaly (HP:0007260)2.24898525
44Duplicated collecting system (HP:0000081)2.24803612
45Abnormality of proline metabolism (HP:0010907)2.23958966
46Hydroxyprolinuria (HP:0003080)2.23958966
47Testicular atrophy (HP:0000029)2.22958300
48Hyperlipoproteinemia (HP:0010980)2.20799911
49Congenital ichthyosiform erythroderma (HP:0007431)2.19846188
50Abnormality of the vitreous humor (HP:0004327)2.16359770
51Alacrima (HP:0000522)2.15306508
52Focal motor seizures (HP:0011153)2.15037961
53Increased serum ferritin (HP:0003281)2.14721537
54Attenuation of retinal blood vessels (HP:0007843)2.14475947
55Abnormality of the renal collecting system (HP:0004742)2.12835487
56Short hallux (HP:0010109)2.11509010
57Inability to walk (HP:0002540)2.10453244
58Non-midline cleft lip (HP:0100335)2.08859381
59Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.08811817
60Abnormality of the renal medulla (HP:0100957)2.06611680
61Pancreatic cysts (HP:0001737)2.05841805
62Abnormality of renin-angiotensin system (HP:0000847)2.03697899
63Long nose (HP:0003189)2.02582430
64Methylmalonic aciduria (HP:0012120)2.01984644
65Severe muscular hypotonia (HP:0006829)2.00676309
66Hypokalemic alkalosis (HP:0001949)2.00615496
67Thyroid-stimulating hormone excess (HP:0002925)10.1534031
68Abnormality of macular pigmentation (HP:0008002)1.99594553
69Abnormality of magnesium homeostasis (HP:0004921)1.98137914
70Tetany (HP:0001281)1.97972584
71Metabolic alkalosis (HP:0200114)1.97779849
72Abnormality of the renal cortex (HP:0011035)1.97514037
73Chromosomal breakage induced by crosslinking agents (HP:0003221)1.96575444
74Azoospermia (HP:0000027)1.95844420
75Molar tooth sign on MRI (HP:0002419)1.93889364
76Abnormality of midbrain morphology (HP:0002418)1.93889364
77Polyuria (HP:0000103)1.93294650
78Abnormality of the columella (HP:0009929)1.90896356
79Congenital sensorineural hearing impairment (HP:0008527)1.90242495
80Abnormality of the pancreatic islet cells (HP:0006476)1.89425297
81Abnormality of endocrine pancreas physiology (HP:0012093)1.89425297
82Prominent supraorbital ridges (HP:0000336)1.88529028
83Pancreatic fibrosis (HP:0100732)1.87445851
84Aplasia/Hypoplasia of the hallux (HP:0008362)1.85187198
85Nephronophthisis (HP:0000090)1.84068477
86Goiter (HP:0000853)1.83238293
87Hypoplastic nipples (HP:0002557)1.82836747
88Abnormal rod and cone electroretinograms (HP:0008323)1.81078759
89Optic nerve hypoplasia (HP:0000609)1.80989692
90High anterior hairline (HP:0009890)1.80431560
91Hyperpituitarism (HP:0010514)1.79518536
92Abnormality of the phalanges of the 2nd finger (HP:0009541)1.72797430
93Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.71618337
94Degeneration of the lateral corticospinal tracts (HP:0002314)1.71618337
95Hypercortisolism (HP:0001578)1.70777740
96Hyperventilation (HP:0002883)1.70118211
97True hermaphroditism (HP:0010459)1.68911717
98Abnormality of iron homeostasis (HP:0011031)1.67962715
99Absent rod-and cone-mediated responses on ERG (HP:0007688)1.66948681
100Increased circulating renin level (HP:0000848)1.66924402

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ADRBK28.32161289
2STK394.74493065
3WNK44.44617743
4PINK14.40790846
5FRK3.85081301
6OXSR12.88534615
7DYRK32.85976279
8ADRBK12.41018946
9TLK12.38440502
10NEK22.05201334
11TYRO32.04054778
12PNCK1.75891006
13IRAK31.68991920
14ERN11.61221479
15ZAK1.60038976
16TRPM71.59312543
17TGFBR11.36380901
18PRKCG1.31977791
19OBSCN1.31439518
20STK31.31359924
21MARK31.25296241
22PRKCE1.23643257
23CDK121.19843592
24BUB11.17726436
25WNK11.12575433
26PIK3CG1.11655548
27GRK11.09778243
28MAPK150.92659008
29SIK20.89428686
30RIPK40.88957391
31TSSK60.83851267
32CAMK40.83654053
33IRAK10.81800955
34CLK10.81793739
35CAMK10.78785723
36TXK0.78402958
37MST40.77267412
38MAPKAPK30.72814783
39DAPK20.70495884
40WNK30.68448905
41MAPKAPK50.68196690
42CAMK2A0.65241708
43MAP2K20.64223151
44MAPK110.60743715
45TIE10.60719808
46RPS6KA60.58156539
47ACVR1B0.57459143
48SGK20.57102458
49PHKG10.57044282
50PHKG20.57044282
51STK38L0.55922479
52MAP4K20.55684058
53CDC70.50713551
54NUAK10.47750659
55PDGFRB0.43550384
56PTK2B0.42717722
57MAPK70.42509627
58SGK4940.42275355
59SGK2230.42275355
60KIT0.42058382
61MAP3K100.41631392
62ALK0.40584017
63MKNK10.40101765
64MAPK130.39662235
65STK240.39550121
66SGK10.38594163
67TAOK30.37389307
68ERBB20.36369498
69CSNK1A10.35704153
70ABL10.34914760
71GRK70.34020288
72PRKCH0.33966749
73MKNK20.33821628
74BCKDK0.33465264
75WEE10.31729350
76IKBKB0.31523534
77BMPR1B0.31360025
78AKT10.30018937
79CSNK1E0.29661578
80MUSK0.29314481
81TNK20.28438891
82PRKCA0.27301423
83CDK30.26566536
84MAP2K10.26285424
85PRKCB0.25865641
86RPS6KL10.23982925
87RPS6KC10.23982925
88PRKG10.23861090
89RPS6KA50.23671166
90ATM0.22842055
91SCYL20.22115847
92PRKACA0.19202366
93GRK50.18651654
94MAP2K60.18198385
95IGF1R0.18165994
96IRAK40.17022862
97INSRR0.16551518
98PASK0.16480460
99CSNK1D0.16124344
100CSF1R0.15614820

Predicted pathways (KEGG)

RankGene SetZ-score
1Linoleic acid metabolism_Homo sapiens_hsa005913.04640462
2Cyanoamino acid metabolism_Homo sapiens_hsa004602.87700093
3Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.81845250
4Caffeine metabolism_Homo sapiens_hsa002322.62430986
5alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.46954694
6Phototransduction_Homo sapiens_hsa047442.26480430
7Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.22736621
8ABC transporters_Homo sapiens_hsa020102.19358983
9Dorso-ventral axis formation_Homo sapiens_hsa043202.12477221
10Morphine addiction_Homo sapiens_hsa050322.10199142
11Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.08419997
12Ovarian steroidogenesis_Homo sapiens_hsa049132.03310494
13Olfactory transduction_Homo sapiens_hsa047402.00160756
14Butanoate metabolism_Homo sapiens_hsa006501.96116901
15Nitrogen metabolism_Homo sapiens_hsa009101.94462620
16Arachidonic acid metabolism_Homo sapiens_hsa005901.90181765
17Mineral absorption_Homo sapiens_hsa049781.86472626
18Steroid hormone biosynthesis_Homo sapiens_hsa001401.82661911
19Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.75527352
20Chemical carcinogenesis_Homo sapiens_hsa052041.64859601
21Vascular smooth muscle contraction_Homo sapiens_hsa042701.63477180
22Primary bile acid biosynthesis_Homo sapiens_hsa001201.62116672
23Ether lipid metabolism_Homo sapiens_hsa005651.54584945
24Selenocompound metabolism_Homo sapiens_hsa004501.54494102
25Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.52421305
26Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.45510205
27Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.40783467
28Glycerolipid metabolism_Homo sapiens_hsa005611.28553723
29Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.23334804
30Retinol metabolism_Homo sapiens_hsa008301.22291087
31Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.21051274
32Glutamatergic synapse_Homo sapiens_hsa047241.20536706
33Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.19305881
34Tryptophan metabolism_Homo sapiens_hsa003801.17019706
35Taste transduction_Homo sapiens_hsa047421.16024858
36Circadian entrainment_Homo sapiens_hsa047131.14937413
37One carbon pool by folate_Homo sapiens_hsa006701.13056541
38Insulin secretion_Homo sapiens_hsa049111.11629715
39Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.03761953
40Long-term depression_Homo sapiens_hsa047301.02130006
41Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.00646508
42RNA degradation_Homo sapiens_hsa030181.00543474
43Calcium signaling pathway_Homo sapiens_hsa040200.99719827
44Sphingolipid metabolism_Homo sapiens_hsa006000.99652842
45Renin secretion_Homo sapiens_hsa049240.98258165
46Serotonergic synapse_Homo sapiens_hsa047260.96838902
47Maturity onset diabetes of the young_Homo sapiens_hsa049500.95836541
48Oxytocin signaling pathway_Homo sapiens_hsa049210.94745834
49NF-kappa B signaling pathway_Homo sapiens_hsa040640.94441117
50Hedgehog signaling pathway_Homo sapiens_hsa043400.94407385
51Basal cell carcinoma_Homo sapiens_hsa052170.92860834
52RNA polymerase_Homo sapiens_hsa030200.92593890
53Primary immunodeficiency_Homo sapiens_hsa053400.92234510
54cGMP-PKG signaling pathway_Homo sapiens_hsa040220.85350352
55Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.84552202
56Sulfur relay system_Homo sapiens_hsa041220.82757662
57Ribosome_Homo sapiens_hsa030100.82265835
58Purine metabolism_Homo sapiens_hsa002300.79045236
59cAMP signaling pathway_Homo sapiens_hsa040240.77172710
60Glycerophospholipid metabolism_Homo sapiens_hsa005640.77058522
61Amphetamine addiction_Homo sapiens_hsa050310.76169160
62Homologous recombination_Homo sapiens_hsa034400.73982402
63Salivary secretion_Homo sapiens_hsa049700.73378971
64Protein export_Homo sapiens_hsa030600.72849598
65Fanconi anemia pathway_Homo sapiens_hsa034600.71391639
66Carbohydrate digestion and absorption_Homo sapiens_hsa049730.66904543
67Peroxisome_Homo sapiens_hsa041460.65922093
68Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.65633425
69Starch and sucrose metabolism_Homo sapiens_hsa005000.65495557
70Cardiac muscle contraction_Homo sapiens_hsa042600.65420387
71Oxidative phosphorylation_Homo sapiens_hsa001900.64676795
72Parkinsons disease_Homo sapiens_hsa050120.60903107
73Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.58674477
74Regulation of autophagy_Homo sapiens_hsa041400.58533824
75Nicotine addiction_Homo sapiens_hsa050330.57974342
76Alzheimers disease_Homo sapiens_hsa050100.57165243
77Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.56730712
78Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.56505214
79Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.55263237
80Complement and coagulation cascades_Homo sapiens_hsa046100.54061467
81Pentose and glucuronate interconversions_Homo sapiens_hsa000400.52443158
82GABAergic synapse_Homo sapiens_hsa047270.50404688
83ECM-receptor interaction_Homo sapiens_hsa045120.49237704
84Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.48189723
85Graft-versus-host disease_Homo sapiens_hsa053320.47513646
86T cell receptor signaling pathway_Homo sapiens_hsa046600.45862222
87Fatty acid biosynthesis_Homo sapiens_hsa000610.43649240
88Pancreatic secretion_Homo sapiens_hsa049720.43184728
89Platelet activation_Homo sapiens_hsa046110.42535561
90Intestinal immune network for IgA production_Homo sapiens_hsa046720.40541352
91Type I diabetes mellitus_Homo sapiens_hsa049400.40496955
92Estrogen signaling pathway_Homo sapiens_hsa049150.38927849
93MAPK signaling pathway_Homo sapiens_hsa040100.38486414
94Metabolic pathways_Homo sapiens_hsa011000.37904133
95Bile secretion_Homo sapiens_hsa049760.36943170
96Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.36936077
97Antigen processing and presentation_Homo sapiens_hsa046120.36478585
98Folate biosynthesis_Homo sapiens_hsa007900.33815249
99Hematopoietic cell lineage_Homo sapiens_hsa046400.32299427
100Glutathione metabolism_Homo sapiens_hsa004800.32167241

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