ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	response to pheromone (GO:0019236)	9.87413223
2	chromosome condensation (GO:0030261)	9.59343716
3	DNA packaging (GO:0006323)	9.34382686
4	sperm capacitation (GO:0048240)	9.14057432
5	plasma membrane fusion (GO:0045026)	8.89831225
6	spermatid nucleus differentiation (GO:0007289)	8.02202947
7	spermatid development (GO:0007286)	7.95194980
8	single strand break repair (GO:0000012)	7.91405882
9	microtubule depolymerization (GO:0007019)	7.79062985
10	sperm-egg recognition (GO:0035036)	7.43005500
11	rRNA methylation (GO:0031167)	7.04326005
12	binding of sperm to zona pellucida (GO:0007339)	6.90255389
13	protein polyglutamylation (GO:0018095)	6.76039624
14	sexual reproduction (GO:0019953)	6.64804694
15	microtubule polymerization or depolymerization (GO:0031109)	6.56515578
16	protein targeting to Golgi (GO:0000042)	6.52714915
17	negative regulation of inclusion body assembly (GO:0090084)	6.50109805
18	multicellular organism reproduction (GO:0032504)	6.49172459
19	calcium ion-dependent exocytosis (GO:0017156)	6.39393730
20	phosphatidylethanolamine biosynthetic process (GO:0006646)	6.35786235
21	reproduction (GO:0000003)	6.30540652
22	establishment of protein localization to Golgi (GO:0072600)	6.26648519
23	cell-cell recognition (GO:0009988)	6.15548976
24	retrograde transport, vesicle recycling within Golgi (GO:0000301)	6.05475653
25	spermatogenesis (GO:0007283)	6.05130745
26	male gamete generation (GO:0048232)	6.03162385
27	axonemal dynein complex assembly (GO:0070286)	5.98562306
28	rRNA modification (GO:0000154)	5.98359453
29	phosphatidylethanolamine metabolic process (GO:0046337)	5.87539143
30	microtubule severing (GO:0051013)	5.76540983
31	centriole replication (GO:0007099)	5.67026517
32	gamete generation (GO:0007276)	5.52176143
33	cellular ketone body metabolic process (GO:0046950)	5.23411859
34	regulation of Rab GTPase activity (GO:0032313)	5.14744719
35	positive regulation of Rab GTPase activity (GO:0032851)	5.14744719
36	regulation of cilium movement (GO:0003352)	5.11747104
37	RNA destabilization (GO:0050779)	5.03798647
38	centriole assembly (GO:0098534)	5.01566932
39	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G	4.91113981
40	regulation of somitogenesis (GO:0014807)	4.89774838
41	cell wall macromolecule catabolic process (GO:0016998)	4.88442826
42	motile cilium assembly (GO:0044458)	4.84678045
43	protein localization to Golgi apparatus (GO:0034067)	4.69170050
44	regulation of transcription involved in cell fate commitment (GO:0060850)	4.66964754
45	cell wall macromolecule metabolic process (GO:0044036)	4.66002520
46	chromatin silencing (GO:0006342)	4.61325612
47	ketone body metabolic process (GO:1902224)	4.61262314
48	regulation of inclusion body assembly (GO:0090083)	4.60984426
49	germ cell development (GO:0007281)	4.55470876
50	cilium or flagellum-dependent cell motility (GO:0001539)	4.53942070
51	single fertilization (GO:0007338)	4.51342940
52	regulation of centriole replication (GO:0046599)	4.43235066
53	multicellular organismal reproductive process (GO:0048609)	4.42692322
54	cellular process involved in reproduction in multicellular organism (GO:0022412)	4.36781525
55	nucleus organization (GO:0006997)	4.15752529
56	negative regulation of Rho protein signal transduction (GO:0035024)	4.10833103
57	regulation of microtubule-based movement (GO:0060632)	4.07191391
58	seminiferous tubule development (GO:0072520)	4.00322229
59	coenzyme catabolic process (GO:0009109)	3.89122423
60	organic cation transport (GO:0015695)	3.87015299
61	fertilization (GO:0009566)	3.84808372
62	musculoskeletal movement (GO:0050881)	3.84143919
63	multicellular organismal movement (GO:0050879)	3.84143919
64	epithelial cilium movement (GO:0003351)	3.74249147
65	polyamine biosynthetic process (GO:0006596)	3.56188576
66	glycerol ether metabolic process (GO:0006662)	3.47925428
67	positive regulation of action potential (GO:0045760)	3.32364945
68	somite rostral/caudal axis specification (GO:0032525)	3.30555033
69	cartilage development involved in endochondral bone morphogenesis (GO:0060351)	3.29071336
70	regulation of interleukin-13 production (GO:0032656)	3.27801247
71	cerebral cortex neuron differentiation (GO:0021895)	3.27015382
72	histone H3-K9 demethylation (GO:0033169)	3.26789491
73	response to acidic pH (GO:0010447)	3.25635635
74	cilium movement (GO:0003341)	3.25589440
75	cranial nerve morphogenesis (GO:0021602)	3.22549242
76	peptidyl-threonine dephosphorylation (GO:0035970)	3.21936634
77	ether metabolic process (GO:0018904)	3.20415990
78	regulation of T-helper 2 cell differentiation (GO:0045628)	3.20198341
79	negative regulation of gene expression, epigenetic (GO:0045814)	3.12865464
80	microtubule nucleation (GO:0007020)	3.11535718
81	homeostasis of number of cells within a tissue (GO:0048873)	3.08002466
82	cellular response to pH (GO:0071467)	3.06375042
83	protein-DNA complex disassembly (GO:0032986)	3.06258466
84	nucleosome disassembly (GO:0006337)	3.06258466
85	multicellular organismal development (GO:0007275)	2.97679857
86	DNA conformation change (GO:0071103)	2.96934387
87	negative regulation of mesenchymal cell apoptotic process (GO:2001054)	2.95346892
88	cell recognition (GO:0008037)	2.95177230
89	tooth mineralization (GO:0034505)	2.95139527
90	mitotic G1 DNA damage checkpoint (GO:0031571)	2.93867129
91	mesenchymal cell differentiation involved in renal system development (GO:2001012)	2.93022180
92	mesenchymal cell differentiation involved in kidney development (GO:0072161)	2.93022180
93	membrane protein intracellular domain proteolysis (GO:0031293)	2.91143661
94	protein depolymerization (GO:0051261)	2.90810070
95	DNA methylation involved in gamete generation (GO:0043046)	2.82237675
96	piRNA metabolic process (GO:0034587)	2.81174025
97	male meiosis I (GO:0007141)	2.78390206
98	fusion of sperm to egg plasma membrane (GO:0007342)	11.7345149
99	acrosome reaction (GO:0007340)	11.7063880
100	sperm motility (GO:0030317)	11.5671200

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	4.64767951
2	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	3.88981812
3	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	3.50785821
4	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	2.40896885
5	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.40896885
6	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.20406727
7	VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human	2.15315121
8	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	2.10449634
9	CBP_20019798_ChIP-Seq_JUKART_Human	2.10449634
10	ELF1_20517297_ChIP-Seq_JURKAT_Human	2.08602751
11	EZH2_22144423_ChIP-Seq_EOC_Human	2.07557261
12	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.06171281
13	ERA_21632823_ChIP-Seq_H3396_Human	2.02627004
14	DROSHA_22980978_ChIP-Seq_HELA_Human	1.90719884
15	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	1.89939399
16	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.87945372
17	RAC3_21632823_ChIP-Seq_H3396_Human	1.87508287
18	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	1.86878887
19	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.86281806
20	NANOG_20526341_ChIP-Seq_ESCs_Human	1.84319987
21	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.83742497
22	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.79499847
23	FUS_26573619_Chip-Seq_HEK293_Human	1.74978764
24	CTCF_27219007_Chip-Seq_Bcells_Human	1.73040405
25	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.68230281
26	BCL6_27268052_Chip-Seq_Bcells_Human	1.67917500
27	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.67844401
28	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.66630944
29	TAF2_19829295_ChIP-Seq_ESCs_Human	1.65826280
30	E2F1_20622854_ChIP-Seq_HELA_Human	1.63671459
31	STAT6_21828071_ChIP-Seq_BEAS2B_Human	1.61826225
32	SMC4_20622854_ChIP-Seq_HELA_Human	1.59801345
33	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.59791257
34	MYC_19829295_ChIP-Seq_ESCs_Human	1.58487760
35	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	1.56726644
36	ER_23166858_ChIP-Seq_MCF-7_Human	1.56021146
37	PHF8_20622854_ChIP-Seq_HELA_Human	1.54108358
38	BCOR_27268052_Chip-Seq_Bcells_Human	1.53306320
39	P68_20966046_ChIP-Seq_HELA_Human	1.53220255
40	CTCF_20526341_ChIP-Seq_ESCs_Human	1.51917508
41	OCT4_20526341_ChIP-Seq_ESCs_Human	1.47864311
42	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.47489127
43	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.44587194
44	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.43127409
45	TP63_22573176_ChIP-Seq_HFKS_Human	1.42642405
46	HNFA_21074721_ChIP-Seq_CACO-2_Human	1.39892202
47	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.38037404
48	CDX2_21074721_ChIP-Seq_CACO-2_Mouse	1.36426358
49	P300_27268052_Chip-Seq_Bcells_Human	1.36331909
50	CBX2_22325352_ChIP-Seq_293T-Rex_Human	1.35956558
51	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.35714367
52	AR_25329375_ChIP-Seq_VCAP_Human	1.35444964
53	RUNX_20019798_ChIP-Seq_JUKART_Human	1.35000220
54	RBPJ_21746931_ChIP-Seq_IB4_Human	1.34548384
55	LXR_22292898_ChIP-Seq_THP-1_Human	1.32118556
56	CEBPB_22108803_ChIP-Seq_LS180_Human	1.31396444
57	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.30829535
58	SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.29103758
59	ETV1_20927104_ChIP-Seq_GIST48_Human	1.29082407
60	P63_20808887_ChIP-Seq_KERATINOCYTES_Human	1.28537393
61	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	1.28136771
62	* ARNT_22903824_ChIP-Seq_MCF-7_Human	1.27252304
63	ERG_20517297_ChIP-Seq_VCAP_Human	1.27167892
64	SMAD3_21741376_ChIP-Seq_ESCs_Human	1.25637647
65	SOX2_22085726_ChIP-Seq_NPCs_Mouse	1.24869847
66	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.23874848
67	KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse	1.23731661
68	* SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.23554477
69	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.21234717
70	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.19538867
71	RUNX1_26923725_Chip-Seq_HPCs_Mouse	1.18711508
72	NFYB_21822215_ChIP-Seq_K562_Human	1.17746670
73	* TP53_18474530_ChIP-ChIP_U2OS_Human	1.17611866
74	SA1_27219007_Chip-Seq_Bcells_Human	1.16152533
75	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.16002081
76	ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.15793623
77	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.15487868
78	P53_21459846_ChIP-Seq_SAOS-2_Human	1.15212256
79	TBL1_22424771_ChIP-Seq_293T_Human	1.14644813
80	PHF8_20622853_ChIP-Seq_HELA_Human	1.11568083
81	GATA6_21074721_ChIP-Seq_CACO-2_Human	1.10393584
82	TAF15_26573619_Chip-Seq_HEK293_Human	1.09853413
83	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.08697235
84	* P300_19829295_ChIP-Seq_ESCs_Human	1.07490528
85	* SMRT_27268052_Chip-Seq_Bcells_Human	1.05260688
86	ZNF274_21170338_ChIP-Seq_K562_Hela	1.04227986
87	* SMAD3_21741376_ChIP-Seq_EPCs_Human	1.03623870
88	HOXB7_26014856_ChIP-Seq_BT474_Human	1.03372131
89	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.02753157
90	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.02154376
91	GATA6_21074721_ChIP-Seq_CACO-2_Mouse	1.01364436
92	* RUNX2_22187159_ChIP-Seq_PCA_Human	1.00292882
93	NFYA_21822215_ChIP-Seq_K562_Human	1.00180809
94	SOX2_19829295_ChIP-Seq_ESCs_Human	0.99021672
95	NANOG_19829295_ChIP-Seq_ESCs_Human	0.99021672
96	KLF5_25053715_ChIP-Seq_YYC3_Human	0.97673276
97	PCGF4_22325352_ChIP-Seq_293T-Rex_Human	0.97582553
98	GF1_26923725_Chip-Seq_HPCs_Mouse	0.96806557
99	OCT1_27270436_Chip-Seq_PROSTATE_Human	0.96246550
100	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	0.95526156

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003878_abnormal_ear_physiology	5.22224259
2	MP0005377_hearing/vestibular/ear_phenot	5.22224259
3	MP0005670_abnormal_white_adipose	4.67194795
4	MP0003698_abnormal_male_reproductive	4.45473055
5	MP0001929_abnormal_gametogenesis	3.83968711
6	MP0001348_abnormal_lacrimal_gland	3.20390710
7	MP0000678_abnormal_parathyroid_gland	2.77200759
8	MP0002161_abnormal_fertility/fecundity	2.52192160
9	MP0003718_maternal_effect	2.26371315
10	MP0003646_muscle_fatigue	2.10713368
11	MP0002234_abnormal_pharynx_morphology	2.00286308
12	MP0005410_abnormal_fertilization	12.4304239
13	MP0005423_abnormal_somatic_nervous	1.96100242
14	MP0002132_abnormal_respiratory_system	1.95341672
15	MP0003011_delayed_dark_adaptation	1.83401428
16	MP0002210_abnormal_sex_determination	1.68633716
17	MP0005310_abnormal_salivary_gland	1.66111968
18	MP0002249_abnormal_larynx_morphology	1.66102216
19	MP0005379_endocrine/exocrine_gland_phen	1.60539110
20	MP0001485_abnormal_pinna_reflex	1.49490072
21	MP0009053_abnormal_anal_canal	1.47215897
22	MP0001145_abnormal_male_reproductive	1.41263326
23	MP0001486_abnormal_startle_reflex	1.38831165
24	MP0002282_abnormal_trachea_morphology	1.34901251
25	MP0000653_abnormal_sex_gland	1.34027849
26	MP0002822_catalepsy	1.28111726
27	MP0008877_abnormal_DNA_methylation	1.27430614
28	MP0000534_abnormal_ureter_morphology	1.27083040
29	MP0004510_myositis	1.26948684
30	MP0005451_abnormal_body_composition	1.20001364
31	MP0001765_abnormal_ion_homeostasis	1.16503069
32	MP0002127_abnormal_cardiovascular_syste	1.15877887
33	MP0004742_abnormal_vestibular_system	1.14974198
34	MP0005395_other_phenotype	1.11167684
35	MP0002735_abnormal_chemical_nociception	1.10006934
36	MP0004859_abnormal_synaptic_plasticity	1.09222857
37	MP0002138_abnormal_hepatobiliary_system	1.06693041
38	MP0003879_abnormal_hair_cell	1.03814956
39	MP0001963_abnormal_hearing_physiology	1.02396185
40	MP0001968_abnormal_touch/_nociception	0.98807185
41	MP0005248_abnormal_Harderian_gland	0.94821595
42	MP0000026_abnormal_inner_ear	0.94716371
43	MP0000681_abnormal_thyroid_gland	0.92913635
44	MP0000955_abnormal_spinal_cord	0.90943525
45	MP0002229_neurodegeneration	0.89690344
46	MP0001873_stomach_inflammation	0.83411586
47	MP0009115_abnormal_fat_cell	0.79094408
48	MP0001879_abnormal_lymphatic_vessel	0.77573577
49	MP0000049_abnormal_middle_ear	0.75218664
50	MP0008569_lethality_at_weaning	0.73809630
51	MP0004484_altered_response_of	0.72778803
52	MP0005666_abnormal_adipose_tissue	0.72225706
53	MP0008961_abnormal_basal_metabolism	0.69671062
54	MP0002067_abnormal_sensory_capabilities	0.69223767
55	MP0005551_abnormal_eye_electrophysiolog	0.68648251
56	MP0000516_abnormal_urinary_system	0.67051179
57	MP0005367_renal/urinary_system_phenotyp	0.67051179
58	MP0002733_abnormal_thermal_nociception	0.65652334
59	MP0005375_adipose_tissue_phenotype	0.64821115
60	MP0005636_abnormal_mineral_homeostasis	0.64175494
61	MP0004085_abnormal_heartbeat	0.64068139
62	MP0003137_abnormal_impulse_conducting	0.63132821
63	MP0002557_abnormal_social/conspecific_i	0.62762975
64	MP0001666_abnormal_nutrient_absorption	0.62133955
65	MP0001905_abnormal_dopamine_level	0.61118983
66	MP0002653_abnormal_ependyma_morphology	0.59987168
67	MP0000003_abnormal_adipose_tissue	0.56249131
68	MP0005623_abnormal_meninges_morphology	0.56245139
69	MP0000613_abnormal_salivary_gland	0.55865024
70	MP0002272_abnormal_nervous_system	0.53934934
71	MP0000249_abnormal_blood_vessel	0.52703612
72	MP0003119_abnormal_digestive_system	0.51624611
73	MP0005253_abnormal_eye_physiology	0.51059880
74	MP0003699_abnormal_female_reproductive	0.50108402
75	MP0002734_abnormal_mechanical_nocicepti	0.49813206
76	MP0009745_abnormal_behavioral_response	0.49767664
77	MP0005647_abnormal_sex_gland	0.49296527
78	MP0005167_abnormal_blood-brain_barrier	0.48508476
79	MP0002572_abnormal_emotion/affect_behav	0.48033208
80	MP0003077_abnormal_cell_cycle	0.47592773
81	MP0000470_abnormal_stomach_morphology	0.47579915
82	MP0003283_abnormal_digestive_organ	0.47500298
83	MP0001440_abnormal_grooming_behavior	0.47179378
84	MP0005083_abnormal_biliary_tract	0.44943138
85	MP0001501_abnormal_sleep_pattern	0.44019460
86	MP0003880_abnormal_central_pattern	0.43729885
87	MP0001970_abnormal_pain_threshold	0.43700979
88	MP0004233_abnormal_muscle_weight	0.40975126
89	MP0003936_abnormal_reproductive_system	0.40601337
90	MP0008995_early_reproductive_senescence	0.40541468
91	MP0009697_abnormal_copulation	0.40273289
92	MP0005166_decreased_susceptibility_to	0.39420285
93	MP0002168_other_aberrant_phenotype	0.36360186
94	MP0002928_abnormal_bile_duct	0.36168671
95	MP0000566_synostosis	0.34427741
96	MP0005535_abnormal_body_temperature	0.32833018
97	MP0000230_abnormal_systemic_arterial	0.32524437
98	MP0000467_abnormal_esophagus_morphology	0.32019243
99	MP0003635_abnormal_synaptic_transmissio	0.31895199
100	MP0004036_abnormal_muscle_relaxation	0.30627249

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Severe visual impairment (HP:0001141)	7.86600263
2	Dynein arm defect of respiratory motile cilia (HP:0012255)	6.08057216
3	Absent/shortened dynein arms (HP:0200106)	6.08057216
4	Asymmetric septal hypertrophy (HP:0001670)	5.62476251
5	Resting tremor (HP:0002322)	4.79176432
6	Attenuation of retinal blood vessels (HP:0007843)	4.75588174
7	Bony spicule pigmentary retinopathy (HP:0007737)	4.72129578
8	Tubulointerstitial nephritis (HP:0001970)	4.65449102
9	Parkinsonism with favorable response to dopaminergic medication (HP:0002548)	4.62750122
10	Abnormal ciliary motility (HP:0012262)	4.51670566
11	Abnormal respiratory motile cilium physiology (HP:0012261)	4.42937350
12	Chronic hepatic failure (HP:0100626)	4.41947723
13	Hyperkalemia (HP:0002153)	4.31980324
14	Abnormal respiratory motile cilium morphology (HP:0005938)	4.26654560
15	Abnormal respiratory epithelium morphology (HP:0012253)	4.26654560
16	Infertility (HP:0000789)	4.22156769
17	Male infertility (HP:0003251)	4.16329176
18	Facial shape deformation (HP:0011334)	4.11794625
19	Potter facies (HP:0002009)	4.11794625
20	Nasal polyposis (HP:0100582)	4.10232905
21	Hypoplastic ischia (HP:0003175)	4.02519869
22	Bell-shaped thorax (HP:0001591)	4.02180856
23	Abnormality of macular pigmentation (HP:0008002)	4.00680102
24	Aplasia/Hypoplasia of the earlobes (HP:0009906)	3.81935886
25	Azoospermia (HP:0000027)	3.80475442
26	Enlarged epiphyses (HP:0010580)	3.75160849
27	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	3.74007543
28	Abnormal rod and cone electroretinograms (HP:0008323)	3.71043388
29	Abnormal spermatogenesis (HP:0008669)	3.65456367
30	Abnormality of the ischium (HP:0003174)	3.56437358
31	Cone-rod dystrophy (HP:0000548)	3.49302949
32	Impulsivity (HP:0100710)	3.43872510
33	Hypoplasia of the thymus (HP:0000778)	3.41119664
34	Unilateral renal agenesis (HP:0000122)	3.38758855
35	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	3.32384736
36	Abnormality of the aortic arch (HP:0012303)	3.30654514
37	Abnormality of the nasal mucosa (HP:0000433)	3.29810759
38	Double outlet right ventricle (HP:0001719)	3.25884716
39	Congenital malformation of the right heart (HP:0011723)	3.25884716
40	Amelogenesis imperfecta (HP:0000705)	3.10841327
41	Postural instability (HP:0002172)	3.03616524
42	Abnormal urine output (HP:0012590)	2.82809336
43	Renal dysplasia (HP:0000110)	2.81349231
44	Nephronophthisis (HP:0000090)	2.76000375
45	Progressive sensorineural hearing impairment (HP:0000408)	2.69552641
46	Truncal obesity (HP:0001956)	2.65968054
47	Progressive cerebellar ataxia (HP:0002073)	2.62775009
48	Abnormality of the costochondral junction (HP:0000919)	2.61448300
49	Abnormality of potassium homeostasis (HP:0011042)	2.60934455
50	Generalized aminoaciduria (HP:0002909)	2.60761619
51	Hypoalphalipoproteinemia (HP:0003233)	2.60597550
52	Ventricular tachycardia (HP:0004756)	2.60271734
53	Stage 5 chronic kidney disease (HP:0003774)	2.58864799
54	Rhinitis (HP:0012384)	2.55672719
55	Abnormality of the parathyroid morphology (HP:0011766)	2.52150371
56	Abnormality of renal excretion (HP:0011036)	2.45301760
57	Polydipsia (HP:0001959)	2.42450812
58	Abnormal drinking behavior (HP:0030082)	2.42450812
59	Portal hypertension (HP:0001409)	2.40509708
60	Insulin-resistant diabetes mellitus (HP:0000831)	2.35541524
61	Flattened epiphyses (HP:0003071)	2.34315748
62	Abnormality of the renal medulla (HP:0100957)	2.33777652
63	Menstrual irregularities (HP:0000858)	2.32827798
64	Abnormality of dental color (HP:0011073)	2.30511872
65	Renovascular hypertension (HP:0100817)	2.27438640
66	Polyuria (HP:0000103)	2.27235634
67	Tubulointerstitial abnormality (HP:0001969)	2.23397928
68	Tetany (HP:0001281)	2.22341485
69	Abnormality of the hepatic vasculature (HP:0006707)	2.20439072
70	Absent epiphyses (HP:0010577)	2.17598604
71	Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)	2.17598604
72	Abnormality of the epiphysis of the femoral head (HP:0010574)	2.13558255
73	Aplasia/Hypoplasia of the sacrum (HP:0008517)	2.12094005
74	Epiphyseal dysplasia (HP:0002656)	2.11774716
75	Abnormality of the pubic bones (HP:0003172)	2.11478786
76	Hyponatremia (HP:0002902)	2.08095967
77	Osteomalacia (HP:0002749)	2.06831574
78	Hyperthyroidism (HP:0000836)	2.06025006
79	Renal Fanconi syndrome (HP:0001994)	1.98392922
80	Bronchiectasis (HP:0002110)	1.98383123
81	Abnormality involving the epiphyses of the lower limbs (HP:0006500)	1.97771232
82	Abnormality of femoral epiphyses (HP:0006499)	1.97771232
83	Abnormal connection of the cardiac segments (HP:0011545)	1.96284774
84	Abnormal ventriculo-arterial connection (HP:0011563)	1.96284774
85	Transposition of the great arteries (HP:0001669)	1.96284774
86	Bradycardia (HP:0001662)	1.95603400
87	Hypophosphatemic rickets (HP:0004912)	1.94197502
88	Abnormality of the femoral head (HP:0003368)	1.93895753
89	Widely patent fontanelles and sutures (HP:0004492)	1.88011929
90	Chronic bronchitis (HP:0004469)	1.87822972
91	Hypoplastic left heart (HP:0004383)	1.84179704
92	Amblyopia (HP:0000646)	1.82925139
93	Hyperuricemia (HP:0002149)	1.81460204
94	Increased purine levels (HP:0004368)	1.81460204
95	Hypoparathyroidism (HP:0000829)	1.81329369
96	Spastic paraparesis (HP:0002313)	1.80371544
97	Recurrent corneal erosions (HP:0000495)	1.79895680
98	Intellectual disability, moderate (HP:0002342)	1.78420679
99	Recurrent pneumonia (HP:0006532)	1.76046030
100	Progressive hearing impairment (HP:0001730)	1.75299295

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PLK4	8.49214901
2	TESK1	6.84305631
3	DDR2	4.77259109
4	INSRR	3.57168190
5	STK38	3.16198922
6	PNCK	3.07727334
7	PLK2	3.06514696
8	BRD4	2.95833530
9	MAP4K2	2.78393490
10	MAPK15	2.75171923
11	CAMK1G	2.27265222
12	STK38L	2.25565656
13	PRKD3	2.16582740
14	PIK3CG	1.83186412
15	WNK1	1.66119122
16	PDPK1	1.65008555
17	PDK1	1.52906791
18	MST1R	1.42536846
19	CDK7	1.32462506
20	SIK2	1.25020283
21	CDK12	1.24242279
22	DYRK1B	1.21802389
23	NEK6	1.16368649
24	PTK2B	1.12744490
25	KSR2	1.09251864
26	LATS2	1.07474698
27	TYRO3	1.00533781
28	MAP3K9	0.90115664
29	MAP2K2	0.84863414
30	AKT3	0.83012098
31	CAMK1D	0.78961600
32	MAP3K11	0.76942827
33	WNK4	0.76422999
34	LATS1	0.73495125
35	RPS6KA2	0.70481369
36	UHMK1	0.68560078
37	MAP3K2	0.65740404
38	BRAF	0.64464682
39	PRKAA2	0.62278272
40	RPS6KA1	0.60964485
41	PRKG1	0.60510066
42	STK39	0.59822514
43	PRKG2	0.59806640
44	ROCK1	0.52814025
45	BMPR1B	0.51134905
46	MAP3K8	0.50468872
47	NTRK3	0.50422658
48	TESK2	0.49566333
49	CAMK1	0.48743027
50	CDK4	0.46488143
51	SGK494	0.45010582
52	SGK223	0.45010582
53	CDK2	0.44621359
54	GSK3B	0.44213227
55	MAPK1	0.43117573
56	CDK1	0.41220291
57	CDK3	0.39306607
58	ARAF	0.36612743
59	RPS6KA6	0.35851424
60	RPS6KL1	0.34530301
61	RPS6KC1	0.34530301
62	MAPK8	0.34530271
63	MARK1	0.32521443
64	PRKCZ	0.32515832
65	MUSK	0.32109312
66	MAP3K1	0.29895492
67	SGK1	0.29795714
68	MTOR	0.29491796
69	CAMK4	0.29278834
70	ZAK	0.29162178
71	CHEK1	0.27892617
72	MAP3K4	0.26745054
73	TAF1	0.26022005
74	PRKCG	0.25809575
75	NUAK1	0.24763711
76	MAPK14	0.24306258
77	PASK	0.23323051
78	ACVR1B	0.21705049
79	PRKCB	0.19483295
80	MAPK11	0.19344295
81	TXK	0.16792059
82	RIPK4	0.16001392
83	MAPK10	0.15988183
84	AKT1	0.15659766
85	TIE1	0.14824364
86	BRSK1	0.14399840
87	MARK2	0.12952642
88	PKN1	0.12889149
89	OXSR1	0.12333733
90	MET	0.12253011
91	MAPK9	0.10728435
92	VRK1	0.10261074
93	JAK3	0.10260069
94	TNIK	0.10197903
95	TLK1	0.09254256
96	PRKACB	0.09020446
97	PINK1	0.08927796
98	SGK2	0.08904050
99	IKBKB	0.08701739
100	PRKCQ	0.08566110

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	7.35294314
2	Fatty acid biosynthesis_Homo sapiens_hsa00061	6.80702418
3	Olfactory transduction_Homo sapiens_hsa04740	3.54695369
4	Butanoate metabolism_Homo sapiens_hsa00650	2.46232115
5	Taste transduction_Homo sapiens_hsa04742	1.91920417
6	Glycerophospholipid metabolism_Homo sapiens_hsa00564	1.90923925
7	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.84738396
8	Allograft rejection_Homo sapiens_hsa05330	1.82671500
9	Type I diabetes mellitus_Homo sapiens_hsa04940	1.82018562
10	Fatty acid degradation_Homo sapiens_hsa00071	1.80742187
11	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.76780838
12	Graft-versus-host disease_Homo sapiens_hsa05332	1.67626206
13	Fatty acid metabolism_Homo sapiens_hsa01212	1.65821133
14	Type II diabetes mellitus_Homo sapiens_hsa04930	1.63746851
15	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	1.63666149
16	Phenylalanine metabolism_Homo sapiens_hsa00360	1.55776091
17	Antigen processing and presentation_Homo sapiens_hsa04612	1.55273916
18	RNA transport_Homo sapiens_hsa03013	1.48352969
19	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	1.48246260
20	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	1.40666956
21	Selenocompound metabolism_Homo sapiens_hsa00450	1.33150256
22	Viral myocarditis_Homo sapiens_hsa05416	1.32645187
23	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	1.28445716
24	Arginine and proline metabolism_Homo sapiens_hsa00330	1.20989320
25	Adipocytokine signaling pathway_Homo sapiens_hsa04920	1.19536765
26	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	1.18098206
27	Endocytosis_Homo sapiens_hsa04144	1.17122938
28	Phototransduction_Homo sapiens_hsa04744	1.15322560
29	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	1.13886471
30	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.04771996
31	Inositol phosphate metabolism_Homo sapiens_hsa00562	1.04365929
32	Protein digestion and absorption_Homo sapiens_hsa04974	1.00305986
33	PPAR signaling pathway_Homo sapiens_hsa03320	0.97037512
34	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.96853048
35	Salivary secretion_Homo sapiens_hsa04970	0.92248026
36	Calcium signaling pathway_Homo sapiens_hsa04020	0.92126427
37	Morphine addiction_Homo sapiens_hsa05032	0.89521290
38	cAMP signaling pathway_Homo sapiens_hsa04024	0.88369528
39	Cardiac muscle contraction_Homo sapiens_hsa04260	0.84753164
40	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.83636453
41	Nicotine addiction_Homo sapiens_hsa05033	0.83043573
42	Circadian entrainment_Homo sapiens_hsa04713	0.81583077
43	Oocyte meiosis_Homo sapiens_hsa04114	0.80816994
44	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.78222522
45	Arginine biosynthesis_Homo sapiens_hsa00220	0.74836237
46	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.73561948
47	Influenza A_Homo sapiens_hsa05164	0.72831021
48	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.72310058
49	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.71429741
50	Tyrosine metabolism_Homo sapiens_hsa00350	0.70955573
51	Fat digestion and absorption_Homo sapiens_hsa04975	0.70378528
52	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.69752710
53	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.69390407
54	ABC transporters_Homo sapiens_hsa02010	0.68933240
55	Gastric acid secretion_Homo sapiens_hsa04971	0.67815457
56	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.66138556
57	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.65712683
58	Renin-angiotensin system_Homo sapiens_hsa04614	0.64743060
59	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.60595689
60	Estrogen signaling pathway_Homo sapiens_hsa04915	0.56735012
61	MAPK signaling pathway_Homo sapiens_hsa04010	0.55016194
62	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.51198700
63	Renin secretion_Homo sapiens_hsa04924	0.51158919
64	Glutamatergic synapse_Homo sapiens_hsa04724	0.50331061
65	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.49303699
66	Insulin secretion_Homo sapiens_hsa04911	0.49157422
67	Glycerolipid metabolism_Homo sapiens_hsa00561	0.48538229
68	Purine metabolism_Homo sapiens_hsa00230	0.48210889
69	VEGF signaling pathway_Homo sapiens_hsa04370	0.46209489
70	Retinol metabolism_Homo sapiens_hsa00830	0.44965523
71	Acute myeloid leukemia_Homo sapiens_hsa05221	0.44176924
72	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.44115470
73	Basal transcription factors_Homo sapiens_hsa03022	0.42984260
74	Viral carcinogenesis_Homo sapiens_hsa05203	0.42514536
75	Bile secretion_Homo sapiens_hsa04976	0.42171705
76	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.39634190
77	Tight junction_Homo sapiens_hsa04530	0.39034308
78	mRNA surveillance pathway_Homo sapiens_hsa03015	0.37282319
79	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.35168218
80	Pancreatic secretion_Homo sapiens_hsa04972	0.34105684
81	Cholinergic synapse_Homo sapiens_hsa04725	0.32922400
82	Serotonergic synapse_Homo sapiens_hsa04726	0.32590137
83	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.30218799
84	Herpes simplex infection_Homo sapiens_hsa05168	0.26903126
85	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.24977707
86	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.23827373
87	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.23163282
88	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.22594531
89	GABAergic synapse_Homo sapiens_hsa04727	0.21657618
90	Long-term potentiation_Homo sapiens_hsa04720	0.21445293
91	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.21442974
92	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.21419362
93	Huntingtons disease_Homo sapiens_hsa05016	0.20656562
94	Adherens junction_Homo sapiens_hsa04520	0.18066093
95	Nitrogen metabolism_Homo sapiens_hsa00910	0.16474991
96	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	0.16329659
97	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.15625038
98	Prolactin signaling pathway_Homo sapiens_hsa04917	0.15244266
99	Fanconi anemia pathway_Homo sapiens_hsa03460	0.14886702
100	Linoleic acid metabolism_Homo sapiens_hsa00591	0.14401826

PPP1R2P9

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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