PPP1R35

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)7.02433107
2DNA deamination (GO:0045006)6.71584915
3viral transcription (GO:0019083)6.42497216
4translational termination (GO:0006415)6.14199443
5translational elongation (GO:0006414)5.50920817
6SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.23104062
7ribosomal small subunit biogenesis (GO:0042274)5.22818937
8maturation of SSU-rRNA (GO:0030490)5.20242611
9protein targeting to ER (GO:0045047)5.08100352
10cotranslational protein targeting to membrane (GO:0006613)5.07920387
11GDP-mannose metabolic process (GO:0019673)5.07841757
12nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.90408630
13viral life cycle (GO:0019058)4.82435560
14protein localization to endoplasmic reticulum (GO:0070972)4.80765813
15establishment of protein localization to endoplasmic reticulum (GO:0072599)4.80593195
16cellular protein complex disassembly (GO:0043624)4.69601223
17translational initiation (GO:0006413)4.69228916
18deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.64645968
19DNA strand elongation involved in DNA replication (GO:0006271)4.39027573
20protein complex disassembly (GO:0043241)4.37709625
21telomere maintenance via semi-conservative replication (GO:0032201)4.28073242
22DNA strand elongation (GO:0022616)4.23293520
23DNA unwinding involved in DNA replication (GO:0006268)4.13949244
24macromolecular complex disassembly (GO:0032984)4.10353894
25deoxyribonucleotide catabolic process (GO:0009264)4.06284267
26pyrimidine nucleotide catabolic process (GO:0006244)4.05528017
27purine deoxyribonucleotide catabolic process (GO:0009155)4.04577048
28antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.99863133
29antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.99863133
30ribosomal large subunit biogenesis (GO:0042273)3.92574504
31pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.83192004
32deoxyribose phosphate catabolic process (GO:0046386)3.78539123
33base-excision repair, AP site formation (GO:0006285)3.74080328
34DNA replication initiation (GO:0006270)3.72158444
35nuclear-transcribed mRNA catabolic process (GO:0000956)3.71836891
36antigen processing and presentation via MHC class Ib (GO:0002475)3.64285719
37formation of translation preinitiation complex (GO:0001731)3.59285170
38positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.58775604
39negative regulation of B cell apoptotic process (GO:0002903)3.56684007
40mRNA catabolic process (GO:0006402)3.52300807
41ribonucleoprotein complex biogenesis (GO:0022613)3.51799907
42telomere maintenance via recombination (GO:0000722)3.46844133
43RNA catabolic process (GO:0006401)3.41662235
44translation (GO:0006412)3.40739979
45response to peptidoglycan (GO:0032494)3.39853180
46folic acid-containing compound biosynthetic process (GO:0009396)3.35104000
47negative regulation of RNA splicing (GO:0033119)3.34158854
48peptidyl-arginine omega-N-methylation (GO:0035247)3.31653021
49protein targeting to membrane (GO:0006612)3.31316469
50antigen processing and presentation of endogenous antigen (GO:0019883)3.26281778
51UV protection (GO:0009650)3.25281519
52negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.24123368
53mitotic recombination (GO:0006312)3.23643762
54pseudouridine synthesis (GO:0001522)3.16279081
55telomere maintenance via telomere lengthening (GO:0010833)3.15105648
56negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.10522501
57nucleotide salvage (GO:0043173)3.09209505
58rRNA processing (GO:0006364)3.08834603
59ncRNA 3-end processing (GO:0043628)3.08628867
602-deoxyribonucleotide metabolic process (GO:0009394)3.06051337
61pentose metabolic process (GO:0019321)3.05538476
62modulation by virus of host process (GO:0019054)3.03335904
63regulation of mammary gland epithelial cell proliferation (GO:0033599)3.02640876
64nucleoside salvage (GO:0043174)3.02234529
65proline biosynthetic process (GO:0006561)3.01195208
66antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.00981426
67regulation of chromatin binding (GO:0035561)2.98814396
68rRNA metabolic process (GO:0016072)2.98455997
69nucleotide-excision repair, DNA gap filling (GO:0006297)2.96433370
70regulation of protein heterodimerization activity (GO:0043497)2.96387478
71Arp2/3 complex-mediated actin nucleation (GO:0034314)2.95068643
72pyrimidine nucleoside salvage (GO:0043097)2.94470361
73pyrimidine-containing compound salvage (GO:0008655)2.94470361
74pteridine-containing compound biosynthetic process (GO:0042559)2.94398120
75viral mRNA export from host cell nucleus (GO:0046784)2.89498513
76pentose-phosphate shunt (GO:0006098)2.88307649
77NIK/NF-kappaB signaling (GO:0038061)2.86930383
78mucosal-associated lymphoid tissue development (GO:0048537)2.85914580
79Peyers patch development (GO:0048541)2.85914580
80granulocyte differentiation (GO:0030851)2.83975212
81histone arginine methylation (GO:0034969)2.82646322
82negative regulation of erythrocyte differentiation (GO:0045647)2.82080916
83mannose metabolic process (GO:0006013)2.79169972
84deoxyribose phosphate metabolic process (GO:0019692)2.78192782
85negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.78013830
86ribosome biogenesis (GO:0042254)2.77658797
87regulation of cytokine production involved in inflammatory response (GO:1900015)2.76924304
88purine-containing compound salvage (GO:0043101)2.76906221
89mature B cell differentiation involved in immune response (GO:0002313)2.76107644
90spliceosomal snRNP assembly (GO:0000387)2.73761327
91pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.72446077
92translesion synthesis (GO:0019985)2.70444098
93guanosine-containing compound biosynthetic process (GO:1901070)2.69857069
94regulation of B cell apoptotic process (GO:0002902)2.69341035
95regulation of translational fidelity (GO:0006450)2.67442770
96rRNA transcription (GO:0009303)2.65857340
97chromatin assembly (GO:0031497)2.65781726
98pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.65341905
99negative regulation of cell aging (GO:0090344)2.64892897
100regulation of interferon-beta biosynthetic process (GO:0045357)2.64031058
101T cell apoptotic process (GO:0070231)2.63234034
102snRNA metabolic process (GO:0016073)2.63049231
103UTP biosynthetic process (GO:0006228)2.63037780
104establishment of integrated proviral latency (GO:0075713)2.62830180
105cellular component biogenesis (GO:0044085)2.62483203
106modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.62314945
107positive regulation by organism of defense response of other organism involved in symbiotic interact2.62314945
108modulation by symbiont of host immune response (GO:0052553)2.62314945
109positive regulation by symbiont of host defense response (GO:0052509)2.62314945
110modulation by symbiont of host defense response (GO:0052031)2.62314945
111modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.62314945
112negative regulation of mRNA processing (GO:0050686)2.62178773
113folic acid metabolic process (GO:0046655)2.61777484
114protein-DNA complex disassembly (GO:0032986)2.60969606
115nucleosome disassembly (GO:0006337)2.60969606
116pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.60306552
117positive thymic T cell selection (GO:0045059)2.59169608
118apoptotic process involved in morphogenesis (GO:0060561)2.59067815
119exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.58735145
120IMP biosynthetic process (GO:0006188)2.58657977
121modulation by symbiont of host cellular process (GO:0044068)2.58594697
122mitotic chromosome condensation (GO:0007076)2.58533677
123termination of RNA polymerase II transcription (GO:0006369)2.57848411
124heme biosynthetic process (GO:0006783)2.56952356
125response to muramyl dipeptide (GO:0032495)2.56865038
126regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.56857738
127heterochromatin organization (GO:0070828)2.56021198
128DNA replication-dependent nucleosome assembly (GO:0006335)2.55207997
129DNA replication-dependent nucleosome organization (GO:0034723)2.55207997
130IMP metabolic process (GO:0046040)2.54047392
131positive regulation of gamma-delta T cell activation (GO:0046645)2.53840497
1323-UTR-mediated mRNA stabilization (GO:0070935)2.53423313
133negative regulation of cell size (GO:0045792)2.53002399
134nucleobase-containing small molecule interconversion (GO:0015949)2.52346902
135peptidyl-arginine methylation (GO:0018216)2.51055631
136peptidyl-arginine N-methylation (GO:0035246)2.51055631
137adenosine receptor signaling pathway (GO:0001973)2.50994610
138pyrimidine nucleoside monophosphate metabolic process (GO:0009129)2.50723387
139nucleobase biosynthetic process (GO:0046112)2.49771172
140metallo-sulfur cluster assembly (GO:0031163)2.49474674
141iron-sulfur cluster assembly (GO:0016226)2.49474674
142protein localization to kinetochore (GO:0034501)2.48380882
143protein localization to chromosome, centromeric region (GO:0071459)2.48331456
144response to interferon-beta (GO:0035456)2.48059346
145deoxyribonucleotide metabolic process (GO:0009262)2.47853877
146proteasome assembly (GO:0043248)2.46873808
147negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.46157089
148nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.45194648
149NADPH regeneration (GO:0006740)2.44718737
1502-deoxyribonucleotide biosynthetic process (GO:0009265)2.44538796
151deoxyribose phosphate biosynthetic process (GO:0046385)2.44538796
152base-excision repair (GO:0006284)2.44526102
153rRNA modification (GO:0000154)2.43657349
154pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.43416281
155purine deoxyribonucleotide metabolic process (GO:0009151)2.43374545
156deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.42394827
157pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.41921130
158mRNA splicing, via spliceosome (GO:0000398)2.40326168
159RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.40326168
160positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.40259145
161DNA replication checkpoint (GO:0000076)2.40181945
162histone H2A acetylation (GO:0043968)2.39365445
163lymphocyte apoptotic process (GO:0070227)2.38470647
164RNA splicing, via transesterification reactions (GO:0000375)2.36319017
165positive regulation of B cell differentiation (GO:0045579)2.34509864
166telomere maintenance (GO:0000723)2.34328177
167negative regulation of mRNA metabolic process (GO:1903312)2.34275482

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.61098436
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.09254454
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.49468810
4MYC_22102868_ChIP-Seq_BL_Human2.57736997
5MYC_18358816_ChIP-ChIP_MESCs_Mouse2.52039547
6FOXM1_23109430_ChIP-Seq_U2OS_Human2.46334377
7SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.37345454
8VDR_21846776_ChIP-Seq_THP-1_Human2.36547185
9MYC_19079543_ChIP-ChIP_MESCs_Mouse2.35907607
10TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.34390690
11TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.29868022
12SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.29218924
13JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.29202263
14ETS1_20019798_ChIP-Seq_JURKAT_Human2.25823358
15E2F4_17652178_ChIP-ChIP_JURKAT_Human2.23186103
16MYC_19030024_ChIP-ChIP_MESCs_Mouse2.20914817
17ELF1_17652178_ChIP-ChIP_JURKAT_Human2.20718046
18NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.20198845
19* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.19123496
20XRN2_22483619_ChIP-Seq_HELA_Human2.17820986
21HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.17582281
22EST1_17652178_ChIP-ChIP_JURKAT_Human2.14232733
23GABP_17652178_ChIP-ChIP_JURKAT_Human2.11765463
24FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.96980655
25P68_20966046_ChIP-Seq_HELA_Human1.89926850
26VDR_23849224_ChIP-Seq_CD4+_Human1.89388183
27TET1_21451524_ChIP-Seq_MESCs_Mouse1.81528696
28CREB1_15753290_ChIP-ChIP_HEK293T_Human1.80276777
29RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.78840997
30KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.78708411
31TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.77294361
32SCL_19346495_ChIP-Seq_HPC-7_Human1.76269331
33KDM2B_26808549_Chip-Seq_SUP-B15_Human1.75672966
34SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.73113626
35KDM2B_26808549_Chip-Seq_DND41_Human1.72013039
36RACK7_27058665_Chip-Seq_MCF-7_Human1.71892301
37CIITA_25753668_ChIP-Seq_RAJI_Human1.71790433
38FOXP3_21729870_ChIP-Seq_TREG_Human1.71531535
39GABP_19822575_ChIP-Seq_HepG2_Human1.68482768
40NELFA_20434984_ChIP-Seq_ESCs_Mouse1.68410322
41DCP1A_22483619_ChIP-Seq_HELA_Human1.65910695
42E2F1_18555785_ChIP-Seq_MESCs_Mouse1.65443588
43SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.62228613
44ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.61318025
45MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.59551998
46MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.57112007
47EGR1_19374776_ChIP-ChIP_THP-1_Human1.55400690
48ELF1_20517297_ChIP-Seq_JURKAT_Human1.55194391
49ERG_20887958_ChIP-Seq_HPC-7_Mouse1.52567735
50BCOR_27268052_Chip-Seq_Bcells_Human1.52269913
51TTF2_22483619_ChIP-Seq_HELA_Human1.51148803
52CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.50387625
53ZFX_18555785_ChIP-Seq_MESCs_Mouse1.49362646
54SRY_22984422_ChIP-ChIP_TESTIS_Rat1.48452189
55CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.47629585
56IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.45974372
57SA1_27219007_Chip-Seq_ERYTHROID_Human1.45952548
58IRF8_22096565_ChIP-ChIP_GC-B_Human1.45223057
59BP1_19119308_ChIP-ChIP_Hs578T_Human1.44890262
60CTCF_27219007_Chip-Seq_ERYTHROID_Human1.44326571
61THAP11_20581084_ChIP-Seq_MESCs_Mouse1.43719448
62HOXB4_20404135_ChIP-ChIP_EML_Mouse1.43487034
63MAF_26560356_Chip-Seq_TH1_Human1.41963412
64CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.41566915
65CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.38941081
66SPI1_23547873_ChIP-Seq_NB4_Human1.38514736
67YY1_21170310_ChIP-Seq_MESCs_Mouse1.35923409
68UTX_26944678_Chip-Seq_JUKART_Human1.35837213
69GATA1_22383799_ChIP-Seq_G1ME_Mouse1.34947068
70E2F1_21310950_ChIP-Seq_MCF-7_Human1.34853868
71CTCF_21964334_Chip-Seq_Bcells_Human1.33762229
72KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.32801698
73NOTCH1_21737748_ChIP-Seq_TLL_Human1.32310380
74DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.30934431
75VDR_24763502_ChIP-Seq_THP-1_Human1.30787563
76HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.30643699
77CTCF_26484167_Chip-Seq_Bcells_Mouse1.29373035
78NCOR1_26117541_ChIP-Seq_K562_Human1.29078489
79FOXP1_21924763_ChIP-Seq_HESCs_Human1.28734522
80TCF7_22412390_ChIP-Seq_EML_Mouse1.28578814
81MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.28249205
82GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.27925368
83E2F1_20622854_ChIP-Seq_HELA_Human1.26712437
84STAT3_1855785_ChIP-Seq_MESCs_Mouse1.26572106
85THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.26420671
86E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.26027262
87FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.25998335
88RUNX1_22412390_ChIP-Seq_EML_Mouse1.25718362
89MAF_26560356_Chip-Seq_TH2_Human1.25604437
90MYCN_18555785_ChIP-Seq_MESCs_Mouse1.24392560
91PHF8_20622854_ChIP-Seq_HELA_Human1.24329433
92NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.24115555
93MYB_21317192_ChIP-Seq_ERMYB_Mouse1.24095193
94POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.23986355
95PU.1_20513432_ChIP-Seq_Bcells_Mouse1.23758202
96ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.22744459
97NANOG_18555785_ChIP-Seq_MESCs_Mouse1.22309858
98RARG_19884340_ChIP-ChIP_MEFs_Mouse1.21179517
99SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.20037209
100SRF_21415370_ChIP-Seq_HL-1_Mouse1.18286043
101SMC4_20622854_ChIP-Seq_HELA_Human1.18139288
102KDM5A_27292631_Chip-Seq_BREAST_Human1.17836586
103SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.17816317
104YY1_22570637_ChIP-Seq_MALME-3M_Human1.17276002
105STAT4_19710469_ChIP-ChIP_TH1__Mouse1.16945475
106CTCF_21964334_ChIP-Seq_BJAB-B_Human1.16555792
107SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.16396802
108CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.14691498
109KLF4_18555785_ChIP-Seq_MESCs_Mouse1.14212775
110PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.14083518
111CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.13397218
112MYB_26560356_Chip-Seq_TH2_Human1.13191189
113CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.11996310
114E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.11080821
115SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.10623368
116MYB_26560356_Chip-Seq_TH1_Human1.10591200
117ERG_21242973_ChIP-ChIP_JURKAT_Human1.10063126
118ELK3_25401928_ChIP-Seq_HUVEC_Human1.09224582
119MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.09131264
120CREB1_26743006_Chip-Seq_LNCaP_Human1.07916559
121RARA_24833708_ChIP-Seq_LIVER_Mouse1.07216940
122BRD4_27068464_Chip-Seq_AML-cells_Mouse1.06619862
123MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.06099303
124SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.05039804
125GATA2_22383799_ChIP-Seq_G1ME_Mouse1.04374501
126EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.04173844
127KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.03691987
128PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.02751276
129TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.01928935
130LXR_22292898_ChIP-Seq_THP-1_Human1.01880820
131KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.00405459
132E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.00097981
133BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.99678851
134TFEB_21752829_ChIP-Seq_HELA_Human0.98830663
135CTCF_18555785_ChIP-Seq_MESCs_Mouse0.98320667
136SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.98203822
137PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.96938630
138ZNF263_19887448_ChIP-Seq_K562_Human0.94274595
139BCL6_27268052_Chip-Seq_Bcells_Human0.92509824

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching3.99201629
2MP0002396_abnormal_hematopoietic_system3.38724739
3MP0004957_abnormal_blastocyst_morpholog3.00334184
4MP0005451_abnormal_body_composition2.88492042
5MP0000685_abnormal_immune_system2.69978102
6MP0010094_abnormal_chromosome_stability2.67634662
7MP0003111_abnormal_nucleus_morphology2.61113086
8MP0001545_abnormal_hematopoietic_system2.58036025
9MP0005397_hematopoietic_system_phenotyp2.58036025
10MP0003077_abnormal_cell_cycle2.55930499
11MP0005058_abnormal_lysosome_morphology2.45184237
12MP0003763_abnormal_thymus_physiology2.42187819
13MP0001835_abnormal_antigen_presentation2.41474264
14MP0000490_abnormal_crypts_of2.40183530
15MP0002398_abnormal_bone_marrow2.19110093
16MP0005671_abnormal_response_to2.16765740
17MP0009278_abnormal_bone_marrow2.12973608
18MP0008007_abnormal_cellular_replicative2.11414560
19MP0000678_abnormal_parathyroid_gland2.09988886
20MP0004185_abnormal_adipocyte_glucose2.08445673
21MP0009785_altered_susceptibility_to2.06516373
22MP0004808_abnormal_hematopoietic_stem2.02660937
23MP0009333_abnormal_splenocyte_physiolog1.97578551
24MP0010352_gastrointestinal_tract_polyps1.95193214
25MP0000689_abnormal_spleen_morphology1.92204227
26MP0008058_abnormal_DNA_repair1.90866829
27MP0002722_abnormal_immune_system1.90061873
28MP0001800_abnormal_humoral_immune1.86795412
29MP0008260_abnormal_autophagy1.79305893
30MP0005076_abnormal_cell_differentiation1.78716760
31MP0005464_abnormal_platelet_physiology1.77299724
32MP0005025_abnormal_response_to1.75627739
33MP0003436_decreased_susceptibility_to1.74080881
34MP0000716_abnormal_immune_system1.72746994
35MP0000703_abnormal_thymus_morphology1.72246973
36MP0002429_abnormal_blood_cell1.70837832
37MP0002420_abnormal_adaptive_immunity1.70172218
38MP0005174_abnormal_tail_pigmentation1.68984842
39MP0001819_abnormal_immune_cell1.66742510
40MP0001873_stomach_inflammation1.65004982
41MP0002452_abnormal_antigen_presenting1.63494817
42MP0002019_abnormal_tumor_incidence1.63162035
43MP0002166_altered_tumor_susceptibility1.61904444
44MP0002723_abnormal_immune_serum1.61689993
45MP0008057_abnormal_DNA_replication1.58977686
46MP0005075_abnormal_melanosome_morpholog1.53375147
47MP0002405_respiratory_system_inflammati1.52353378
48MP0000465_gastrointestinal_hemorrhage1.51199470
49MP0003453_abnormal_keratinocyte_physiol1.50909568
50MP0009840_abnormal_foam_cell1.49134837
51MP0005000_abnormal_immune_tolerance1.46405298
52MP0010155_abnormal_intestine_physiology1.45718372
53MP0005501_abnormal_skin_physiology1.45147393
54MP0003656_abnormal_erythrocyte_physiolo1.44511236
55MP0002132_abnormal_respiratory_system1.43003955
56MP0004381_abnormal_hair_follicle1.42810717
57MP0003806_abnormal_nucleotide_metabolis1.41291890
58MP0000313_abnormal_cell_death1.41122030
59MP0009379_abnormal_foot_pigmentation1.40546631
60MP0008932_abnormal_embryonic_tissue1.38999694
61MP0001853_heart_inflammation1.38059626
62MP0000350_abnormal_cell_proliferation1.35709704
63MP0005387_immune_system_phenotype1.34944053
64MP0001790_abnormal_immune_system1.34944053
65MP0005666_abnormal_adipose_tissue1.30486409
66MP0001730_embryonic_growth_arrest1.29627497
67MP0001849_ear_inflammation1.26879193
68MP0003866_abnormal_defecation1.25673274
69MP0001661_extended_life_span1.25176391
70MP0003303_peritoneal_inflammation1.21542125
71MP0000858_altered_metastatic_potential1.20181580
72MP0003186_abnormal_redox_activity1.15973381
73MP0002249_abnormal_larynx_morphology1.15299068
74MP0000750_abnormal_muscle_regeneration1.15145605
75MP0003705_abnormal_hypodermis_morpholog1.14067373
76MP0006054_spinal_hemorrhage1.11600101
77MP0001845_abnormal_inflammatory_respons1.10790754
78MP0002419_abnormal_innate_immunity1.10474050
79MP0003786_premature_aging1.08987407
80MP0002006_tumorigenesis1.06998956
81MP0004510_myositis1.06171267
82MP0002080_prenatal_lethality1.05661162
83MP0002148_abnormal_hypersensitivity_rea1.03042513
84MP0004858_abnormal_nervous_system1.02322008
85MP0002095_abnormal_skin_pigmentation1.01734828
86MP0000477_abnormal_intestine_morphology1.00932724
87MP0003191_abnormal_cellular_cholesterol1.00123506
88MP0001348_abnormal_lacrimal_gland0.96799612
89MP0005375_adipose_tissue_phenotype0.95776528
90MP0008469_abnormal_protein_level0.95433199
91MP0006036_abnormal_mitochondrial_physio0.94388170
92MP0000681_abnormal_thyroid_gland0.93987791
93MP0004947_skin_inflammation0.93826240
94MP0002653_abnormal_ependyma_morphology0.90819020
95MP0010307_abnormal_tumor_latency0.90666278
96MP0003724_increased_susceptibility_to0.89223102
97MP0003718_maternal_effect0.88903496
98MP0003136_yellow_coat_color0.88526562
99MP0009931_abnormal_skin_appearance0.88311526
100MP0001697_abnormal_embryo_size0.88252780
101MP0010030_abnormal_orbit_morphology0.84936232
102MP0000358_abnormal_cell_content/0.84332973
103MP0005330_cardiomyopathy0.83972277
104MP0002796_impaired_skin_barrier0.82363829
105MP0001663_abnormal_digestive_system0.81093762
106MP0000598_abnormal_liver_morphology0.80439989
107MP0002234_abnormal_pharynx_morphology0.80381865
108MP0002163_abnormal_gland_morphology0.80321518
109MP0003315_abnormal_perineum_morphology0.79833186
110MP0002254_reproductive_system_inflammat0.76345785
111MP0005083_abnormal_biliary_tract0.76001472
112MP0003172_abnormal_lysosome_physiology0.74396280
113MP0003567_abnormal_fetal_cardiomyocyte0.73253901
114MP0001881_abnormal_mammary_gland0.73049039
115MP0004147_increased_porphyrin_level0.72787336
116MP0002210_abnormal_sex_determination0.71991183
117MP0001919_abnormal_reproductive_system0.71851582
118MP0002160_abnormal_reproductive_system0.71628407
119MP0003300_gastrointestinal_ulcer0.71387942
120MP0006035_abnormal_mitochondrial_morpho0.69835918
121MP0002086_abnormal_extraembryonic_tissu0.69394979
122MP0002085_abnormal_embryonic_tissue0.69006248
123MP0001929_abnormal_gametogenesis0.67985874
124MP0001145_abnormal_male_reproductive0.67101810
125MP0001672_abnormal_embryogenesis/_devel0.66843615
126MP0005380_embryogenesis_phenotype0.66843615
127MP0001293_anophthalmia0.65984794
128MP0003984_embryonic_growth_retardation0.65620825
129MP0006082_CNS_inflammation0.63837896
130MP0002088_abnormal_embryonic_growth/wei0.62628300
131MP0005023_abnormal_wound_healing0.62436951
132MP0001986_abnormal_taste_sensitivity0.62288023
133MP0002084_abnormal_developmental_patter0.62228461

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)6.70446888
2Abnormal number of erythroid precursors (HP:0012131)6.59605464
3Reticulocytopenia (HP:0001896)5.83091718
4Thrombocytosis (HP:0001894)4.74274873
5Testicular atrophy (HP:0000029)4.57855251
6Pallor (HP:0000980)4.10870258
7Aplastic anemia (HP:0001915)3.81751656
8Macrocytic anemia (HP:0001972)3.79408253
9IgM deficiency (HP:0002850)3.53970256
10Elevated erythrocyte sedimentation rate (HP:0003565)3.47714590
11Nasal polyposis (HP:0100582)3.39678604
12Chronic otitis media (HP:0000389)3.39299539
13Decreased activity of mitochondrial respiratory chain (HP:0008972)3.23570273
14Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.23570273
15Hypertensive crisis (HP:0100735)3.23164866
16Chronic obstructive pulmonary disease (HP:0006510)3.22992012
17Obstructive lung disease (HP:0006536)3.22992012
18Petechiae (HP:0000967)3.21457430
19Abnormality of the heme biosynthetic pathway (HP:0010472)3.19699208
20Recurrent bronchitis (HP:0002837)3.12153986
21Reduced antithrombin III activity (HP:0001976)3.09369577
22Abnormality of the nasal mucosa (HP:0000433)3.06841375
23Type I transferrin isoform profile (HP:0003642)3.04572345
24Oral leukoplakia (HP:0002745)2.94468953
25Panhypogammaglobulinemia (HP:0003139)2.91243622
26Microvesicular hepatic steatosis (HP:0001414)2.90793489
27Prolonged bleeding time (HP:0003010)2.88911566
28Facial hemangioma (HP:0000329)2.87977304
29Abnormality of reticulocytes (HP:0004312)2.87756907
30Abnormality of T cell physiology (HP:0011840)2.83893648
31Recurrent bacterial skin infections (HP:0005406)2.82690160
32Microretrognathia (HP:0000308)2.81515610
33Broad distal phalanx of finger (HP:0009836)2.79132459
34Hyperthyroidism (HP:0000836)2.75208849
35Impaired platelet aggregation (HP:0003540)2.68582351
36Abnormal platelet function (HP:0011869)2.68582351
37Eczematoid dermatitis (HP:0000976)2.68102753
38Multiple enchondromatosis (HP:0005701)2.65389776
39Abnormality of the thoracic spine (HP:0100711)2.64371949
4011 pairs of ribs (HP:0000878)2.63082944
41Poikiloderma (HP:0001029)2.60082355
42Abnormal protein glycosylation (HP:0012346)2.58906185
43Abnormal glycosylation (HP:0012345)2.58906185
44Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.58906185
45Abnormal protein N-linked glycosylation (HP:0012347)2.58906185
46Abnormality of T cells (HP:0002843)2.58747909
47Aplasia/Hypoplasia of the sacrum (HP:0008517)2.58704907
48Abnormality of B cell number (HP:0010975)2.54458288
49B lymphocytopenia (HP:0010976)2.54458288
50Gastrointestinal inflammation (HP:0004386)2.54038654
51Thoracic kyphosis (HP:0002942)2.51687354
52Progressive muscle weakness (HP:0003323)2.48314370
53Muscle fiber atrophy (HP:0100295)2.47325896
54Hemorrhage of the eye (HP:0011885)2.47016178
55Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.46299947
56Ulnar bowing (HP:0003031)2.45947852
57Seborrheic dermatitis (HP:0001051)2.45914651
58Respiratory difficulties (HP:0002880)2.43664169
59Recurrent viral infections (HP:0004429)2.43349249
60Thin bony cortex (HP:0002753)2.43051605
61Renal Fanconi syndrome (HP:0001994)2.42445086
62Mediastinal lymphadenopathy (HP:0100721)2.38870719
63Spinal cord lesions (HP:0100561)2.36783917
64Syringomyelia (HP:0003396)2.36783917
65Basal cell carcinoma (HP:0002671)2.34998618
66Truncus arteriosus (HP:0001660)2.33982151
67Increased serum ferritin (HP:0003281)2.31848565
68Annular pancreas (HP:0001734)2.28211483
69Absent thumb (HP:0009777)2.27833892
70Vaginal fistula (HP:0004320)2.27696015
71Abnormal delayed hypersensitivity skin test (HP:0002963)2.27395075
72Degeneration of anterior horn cells (HP:0002398)2.27174927
73Abnormality of the anterior horn cell (HP:0006802)2.27174927
74Inflammation of the large intestine (HP:0002037)2.26974096
75Selective tooth agenesis (HP:0001592)2.26954226
76Increased neuronal autofluorescent lipopigment (HP:0002074)2.25550148
77Myelodysplasia (HP:0002863)2.23558495
78Colon cancer (HP:0003003)2.21792457
79Recurrent fungal infections (HP:0002841)2.20810790
80Abnormality of the columella (HP:0009929)2.20054736
81Myopathic facies (HP:0002058)2.19699587
82Epistaxis (HP:0000421)2.19680114
83Pancytopenia (HP:0001876)2.18504118
84Capillary hemangiomas (HP:0005306)2.16475448
85Myositis (HP:0100614)2.13899508
86IgG deficiency (HP:0004315)2.13774604
87Lymphoma (HP:0002665)2.13044491
88Progressive external ophthalmoplegia (HP:0000590)2.12243409
89Microcytic anemia (HP:0001935)2.12173013
90Cellulitis (HP:0100658)2.09640962
91Lipid accumulation in hepatocytes (HP:0006561)2.08955372
92Intestinal fistula (HP:0100819)2.08800240
93Rectovaginal fistula (HP:0000143)2.08139761
94Rectal fistula (HP:0100590)2.08139761
95Abnormality of macrophages (HP:0004311)2.07579684
96Acute lymphatic leukemia (HP:0006721)2.06204015
97Rough bone trabeculation (HP:0100670)2.05196590
98Increased cerebral lipofuscin (HP:0011813)2.04287182
99Combined immunodeficiency (HP:0005387)2.04143850
100Recurrent skin infections (HP:0001581)2.03921044
101Optic nerve coloboma (HP:0000588)2.03290298
102Bronchitis (HP:0012387)2.02700412
103Self-mutilation (HP:0000742)2.01028246
104Agammaglobulinemia (HP:0004432)2.01012164
105Meningitis (HP:0001287)2.00515265
106Hypochromic anemia (HP:0001931)2.00507648
107Granulocytopenia (HP:0001913)1.99571380
108Cleft eyelid (HP:0000625)1.99564127
109Abnormality of cells of the lymphoid lineage (HP:0012140)1.99560320
110Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.98677480
111Increased hepatocellular lipid droplets (HP:0006565)1.98293445
112Recurrent cutaneous fungal infections (HP:0011370)1.98229183
113Chronic mucocutaneous candidiasis (HP:0002728)1.98229183
114Abnormal gallbladder physiology (HP:0012438)1.97597872
115Cholecystitis (HP:0001082)1.97597872
116Abnormal trabecular bone morphology (HP:0100671)1.96479557
117Stridor (HP:0010307)1.96408917
118Abnormality of pyrimidine metabolism (HP:0004353)1.93751159
119Hypoplasia of the thymus (HP:0000778)1.93676669
120Hepatosplenomegaly (HP:0001433)1.90952979
121Rib fusion (HP:0000902)1.90414598
122Lymphopenia (HP:0001888)1.90232770
123Severe combined immunodeficiency (HP:0004430)1.89723136
124Recurrent abscess formation (HP:0002722)1.88665937
125Colitis (HP:0002583)1.87979247
126Hepatocellular necrosis (HP:0001404)1.87931217
127Achilles tendon contracture (HP:0001771)1.87505531
128Gastrointestinal stroma tumor (HP:0100723)1.85837375
129Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.85182289
130Dicarboxylic aciduria (HP:0003215)1.83997289
131Abnormality of dicarboxylic acid metabolism (HP:0010995)1.83997289
132Chronic sinusitis (HP:0011109)1.83690155
133Bone marrow hypocellularity (HP:0005528)1.83476785
134Pustule (HP:0200039)1.83427023
135Increased intramyocellular lipid droplets (HP:0012240)1.82526859
136Dysautonomia (HP:0002459)1.82423787
137Absent rod-and cone-mediated responses on ERG (HP:0007688)1.82361148
138Aplasia/Hypoplasia of the thymus (HP:0010515)1.81173050
139Increased muscle lipid content (HP:0009058)1.81050406
140Bulbar palsy (HP:0001283)1.80597122
141Male infertility (HP:0003251)1.79731983
142Premature skin wrinkling (HP:0100678)1.77443517
143Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.77279142
144Exertional dyspnea (HP:0002875)1.76247878
145Neutropenia (HP:0001875)1.74542936
1463-Methylglutaconic aciduria (HP:0003535)1.74480406
147Increased IgE level (HP:0003212)1.74361972
148Type 2 muscle fiber atrophy (HP:0003554)1.74126695
149Asplenia (HP:0001746)1.73374316
150Purpura (HP:0000979)1.73172051
151Amaurosis fugax (HP:0100576)1.73116689
152Abnormality of iron homeostasis (HP:0011031)1.72513863
153Premature graying of hair (HP:0002216)1.71137924
154Large eyes (HP:0001090)1.71005847
155Ragged-red muscle fibers (HP:0003200)1.70961603
156Squamous cell carcinoma (HP:0002860)1.69540565
157Albinism (HP:0001022)1.67802331
158Birth length less than 3rd percentile (HP:0003561)1.67061288
159Neoplasm of the pancreas (HP:0002894)1.66868912
160Increased serum lactate (HP:0002151)1.65719454
161Hepatic necrosis (HP:0002605)1.64818680

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SMG13.99222777
2MAP4K13.23232166
3NME23.15686681
4BUB13.09818710
5VRK23.09449786
6EEF2K2.78191832
7MAP3K102.73504796
8WEE12.58748930
9TESK22.37225374
10PRPF4B2.32431781
11IRAK32.29796943
12ARAF2.26206632
13STK162.24375649
14TLK12.10119386
15FLT32.03312845
16DYRK32.02440250
17NEK21.95395802
18LRRK21.92903073
19PKN21.90073397
20KIT1.87187134
21KDR1.86128330
22ACVR1B1.81499798
23ERN11.76991525
24PIM21.72151017
25BTK1.71748757
26RPS6KB21.68662871
27TRIB31.64911961
28MAP3K111.57997241
29CDC71.57738924
30VRK11.55029323
31SCYL21.55010289
32BLK1.48635528
33MAP3K131.47880973
34ZAP701.47093941
35GRK61.46606040
36TBK11.38293178
37STK101.37153405
38CSF1R1.35866057
39CDK191.35857464
40MAPKAPK31.35089172
41TNK21.33040232
42BRAF1.32155353
43TAOK21.30989942
44BCKDK1.30909972
45RPS6KA41.29998880
46CDK41.29759124
47CDK71.25935819
48CDK81.25769413
49TGFBR11.23621901
50CDK121.22365431
51MAP3K81.16442619
52TYK21.15897229
53PASK1.10710591
54IRAK41.10528224
55IRAK21.08695689
56PIM11.08626598
57JAK31.03521495
58MAPK151.02737611
59PAK41.02303344
60MARK30.99978860
61EIF2AK10.95574907
62MAP3K10.95172673
63SYK0.95026932
64RIPK40.93086305
65TEC0.92442121
66NLK0.91049415
67ABL20.90529389
68ATR0.90424355
69TESK10.90139138
70TAF10.87537031
71IKBKE0.87383437
72AURKB0.86431766
73ILK0.86317316
74MATK0.85064048
75PLK10.84478005
76MAP2K30.82029649
77SIK20.81909653
78TGFBR20.81753843
79AURKA0.78902256
80TAOK10.77509101
81PDPK10.77156187
82BRSK20.76200008
83MAPK110.75746656
84MAP3K30.72276558
85TNIK0.71865914
86SIK30.71514727
87CCNB10.69579382
88DYRK1B0.68768083
89CDK90.68170939
90STK40.68145641
91PRKD20.68084999
92BRSK10.67027343
93MAPK120.65963031
94PTK60.64924537
95HIPK20.64538592
96LYN0.64520320
97LCK0.64197125
98ICK0.63171193
99EIF2AK30.62836284
100MTOR0.61324507
101CHEK20.58496840
102RPS6KA50.57584880
103TAOK30.57584261
104TXK0.57089557
105MAPK40.56394317
106PRKCI0.55467452
107SIK10.55272217
108IKBKB0.54193575
109RAF10.52003130
110MAP2K20.51754504
111DAPK30.51303528
112TTK0.51168847
113MARK20.51047235
114PRKG20.50265604
115BMX0.50118588
116FGFR40.50099613
117EPHA20.49752370
118NEK10.49477047
119CLK10.48039634
120PAK10.47670886
121CSNK2A20.45802325
122DAPK10.45556044
123MAP3K140.44673126
124KSR20.44518737
125FES0.43826873
126HCK0.43100812
127PRKD30.43076066
128CDC42BPA0.41962978
129RPS6KA20.41386604
130MAPKAPK20.41217802
131MELK0.41066913
132CSK0.39965814
133MOS0.39907207
134CSNK2A10.39763687
135CHEK10.39080620
136SRPK10.38637721
137RPS6KA10.38130332
138RPS6KA60.37688440
139RPS6KL10.36280157
140RPS6KC10.36280157
141JAK20.35965656
142PDK10.35950223
143AKT20.34694933

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.13728065
2DNA replication_Homo sapiens_hsa030305.00849994
3Mismatch repair_Homo sapiens_hsa034303.56624974
4Base excision repair_Homo sapiens_hsa034103.12464068
5Spliceosome_Homo sapiens_hsa030402.82584355
6Homologous recombination_Homo sapiens_hsa034402.71050537
7Sulfur relay system_Homo sapiens_hsa041222.67298770
8Pyrimidine metabolism_Homo sapiens_hsa002402.36770942
9Proteasome_Homo sapiens_hsa030502.31988837
10Nucleotide excision repair_Homo sapiens_hsa034202.25839312
11RNA polymerase_Homo sapiens_hsa030202.11060154
12Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.02431050
13Primary immunodeficiency_Homo sapiens_hsa053401.99051692
14Folate biosynthesis_Homo sapiens_hsa007901.84135879
15One carbon pool by folate_Homo sapiens_hsa006701.82576625
16RNA transport_Homo sapiens_hsa030131.82529141
17Cell cycle_Homo sapiens_hsa041101.76004124
18Pentose phosphate pathway_Homo sapiens_hsa000301.68275228
19Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.55002396
20Drug metabolism - other enzymes_Homo sapiens_hsa009831.47279046
21Antigen processing and presentation_Homo sapiens_hsa046121.45594984
22Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.41228862
23Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.40665007
24Fanconi anemia pathway_Homo sapiens_hsa034601.39816501
25Systemic lupus erythematosus_Homo sapiens_hsa053221.36210285
26Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.26379052
27Non-homologous end-joining_Homo sapiens_hsa034501.24180557
28Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.22889051
29RNA degradation_Homo sapiens_hsa030181.18493487
30p53 signaling pathway_Homo sapiens_hsa041151.16377240
31Herpes simplex infection_Homo sapiens_hsa051681.12082416
32Toll-like receptor signaling pathway_Homo sapiens_hsa046201.09370449
33VEGF signaling pathway_Homo sapiens_hsa043701.08470365
34N-Glycan biosynthesis_Homo sapiens_hsa005101.07684449
35Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.04098109
36Acute myeloid leukemia_Homo sapiens_hsa052211.01494986
37B cell receptor signaling pathway_Homo sapiens_hsa046621.00704571
38Pancreatic cancer_Homo sapiens_hsa052120.97688810
39Selenocompound metabolism_Homo sapiens_hsa004500.97389057
40Purine metabolism_Homo sapiens_hsa002300.94644967
41Biosynthesis of amino acids_Homo sapiens_hsa012300.92412341
42Measles_Homo sapiens_hsa051620.88671510
43Shigellosis_Homo sapiens_hsa051310.88415375
44Cysteine and methionine metabolism_Homo sapiens_hsa002700.88218049
45Hematopoietic cell lineage_Homo sapiens_hsa046400.87539038
46mRNA surveillance pathway_Homo sapiens_hsa030150.86779821
47Basal transcription factors_Homo sapiens_hsa030220.86736814
48Thyroid cancer_Homo sapiens_hsa052160.86164955
49Cyanoamino acid metabolism_Homo sapiens_hsa004600.85227058
50Viral carcinogenesis_Homo sapiens_hsa052030.82431262
51Epstein-Barr virus infection_Homo sapiens_hsa051690.82427490
52Leishmaniasis_Homo sapiens_hsa051400.81189655
53Intestinal immune network for IgA production_Homo sapiens_hsa046720.78068660
54Transcriptional misregulation in cancer_Homo sapiens_hsa052020.77559777
55mTOR signaling pathway_Homo sapiens_hsa041500.75896944
56Legionellosis_Homo sapiens_hsa051340.74908927
57Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.72823682
58HTLV-I infection_Homo sapiens_hsa051660.72109902
59Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.70816944
60Apoptosis_Homo sapiens_hsa042100.70662259
61Allograft rejection_Homo sapiens_hsa053300.67302872
62Chronic myeloid leukemia_Homo sapiens_hsa052200.65809415
63NF-kappa B signaling pathway_Homo sapiens_hsa040640.63218656
64Notch signaling pathway_Homo sapiens_hsa043300.63159758
65Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.61921173
66Carbon metabolism_Homo sapiens_hsa012000.61748566
67RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.61144133
68Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.61066377
69Fructose and mannose metabolism_Homo sapiens_hsa000510.60415132
70Neurotrophin signaling pathway_Homo sapiens_hsa047220.59770132
71Oxidative phosphorylation_Homo sapiens_hsa001900.59377847
72Hepatitis C_Homo sapiens_hsa051600.59187097
73Tuberculosis_Homo sapiens_hsa051520.57912493
74Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.57640245
75Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.57405316
76Autoimmune thyroid disease_Homo sapiens_hsa053200.57163406
77Protein export_Homo sapiens_hsa030600.55520400
78Galactose metabolism_Homo sapiens_hsa000520.54821537
79Bladder cancer_Homo sapiens_hsa052190.52892360
80Pentose and glucuronate interconversions_Homo sapiens_hsa000400.52059522
81Glutathione metabolism_Homo sapiens_hsa004800.52002009
82Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.51827737
83Hepatitis B_Homo sapiens_hsa051610.50670104
84Jak-STAT signaling pathway_Homo sapiens_hsa046300.50198915
85Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.49809030
86Longevity regulating pathway - mammal_Homo sapiens_hsa042110.48362239
87Endometrial cancer_Homo sapiens_hsa052130.45579901
88Alcoholism_Homo sapiens_hsa050340.44967669
89NOD-like receptor signaling pathway_Homo sapiens_hsa046210.43372295
90T cell receptor signaling pathway_Homo sapiens_hsa046600.43283282
91Graft-versus-host disease_Homo sapiens_hsa053320.42794903
92Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.42199711
93Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.42056682
94Caffeine metabolism_Homo sapiens_hsa002320.41971674
95Other glycan degradation_Homo sapiens_hsa005110.41818984
96Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.41757194
97Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.41343197
98Toxoplasmosis_Homo sapiens_hsa051450.40314806
99TNF signaling pathway_Homo sapiens_hsa046680.39060587
100Parkinsons disease_Homo sapiens_hsa050120.38444250
101Phenylalanine metabolism_Homo sapiens_hsa003600.37331287
102Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.35989478
103Inositol phosphate metabolism_Homo sapiens_hsa005620.35578791
104Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.35517714
105Influenza A_Homo sapiens_hsa051640.34966478
106Colorectal cancer_Homo sapiens_hsa052100.34684304
107Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.34613184
1082-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.34365089
109Alzheimers disease_Homo sapiens_hsa050100.34074463
110Osteoclast differentiation_Homo sapiens_hsa043800.33764068
111Small cell lung cancer_Homo sapiens_hsa052220.33071298
112Huntingtons disease_Homo sapiens_hsa050160.33055627
113Non-small cell lung cancer_Homo sapiens_hsa052230.31869686
114Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.31807618
115Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.30253383
116Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.30002410
117Glycosaminoglycan degradation_Homo sapiens_hsa005310.29364284
118Central carbon metabolism in cancer_Homo sapiens_hsa052300.27691381
119Pertussis_Homo sapiens_hsa051330.25880490
120Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.25594737
121Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.24660075
122Metabolic pathways_Homo sapiens_hsa011000.23914169
123Pyruvate metabolism_Homo sapiens_hsa006200.23263374

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