PPP1R37

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1gamma-aminobutyric acid transport (GO:0015812)6.30547844
2neurofilament cytoskeleton organization (GO:0060052)6.17470727
3response to dietary excess (GO:0002021)5.39837584
4neuromuscular process controlling posture (GO:0050884)4.71833733
5glycoprotein biosynthetic process (GO:0009101)4.57138769
6ionotropic glutamate receptor signaling pathway (GO:0035235)4.42608012
7lung-associated mesenchyme development (GO:0060484)4.27127051
8negative regulation of synaptic transmission, GABAergic (GO:0032229)4.26123533
9endothelial cell chemotaxis (GO:0035767)4.15004170
10negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)4.12424515
11positive regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030949)4.08779245
12proline transport (GO:0015824)4.02564246
13positive regulation of action potential (GO:0045760)4.02064252
14positive regulation of synapse maturation (GO:0090129)4.02051695
15lipid translocation (GO:0034204)4.00393789
16phospholipid translocation (GO:0045332)4.00393789
17membrane tubulation (GO:0097320)3.92055891
18alpha-linolenic acid metabolic process (GO:0036109)3.89883133
19erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.84218858
20L-phenylalanine catabolic process (GO:0006559)3.84218858
21lysine metabolic process (GO:0006553)3.83520272
22lysine catabolic process (GO:0006554)3.83520272
23sex determination (GO:0007530)3.81605400
24L-phenylalanine metabolic process (GO:0006558)3.79475081
25erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.79475081
26neuronal action potential (GO:0019228)3.77313237
27peptidyl-tyrosine autophosphorylation (GO:0038083)3.74784721
28regulation of energy homeostasis (GO:2000505)3.71466639
29regulation of cholesterol homeostasis (GO:2000188)3.61494114
30neuron projection extension involved in neuron projection guidance (GO:1902284)3.60890385
31axon extension involved in axon guidance (GO:0048846)3.60890385
32regulation of timing of cell differentiation (GO:0048505)3.58878467
33positive regulation of protein kinase C signaling (GO:0090037)3.56618127
34negative regulation of axon extension (GO:0030517)3.56191454
35male sex determination (GO:0030238)3.54508246
36semaphorin-plexin signaling pathway (GO:0071526)3.49701099
37establishment of mitochondrion localization (GO:0051654)3.48075552
38synaptic vesicle exocytosis (GO:0016079)3.46906958
39triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.46524157
40mitochondrion transport along microtubule (GO:0047497)3.45474199
41establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.45474199
42dicarboxylic acid biosynthetic process (GO:0043650)3.44955899
43RNA destabilization (GO:0050779)3.40696060
44glutamate receptor signaling pathway (GO:0007215)3.40605309
45sulfur amino acid catabolic process (GO:0000098)3.33976137
46regulation of synapse maturation (GO:0090128)3.30413521
47membrane depolarization during action potential (GO:0086010)3.29957527
48embryonic eye morphogenesis (GO:0048048)3.27890632
49negative regulation of axon extension involved in axon guidance (GO:0048843)3.27164577
50synaptic vesicle maturation (GO:0016188)3.24598796
51positive regulation of systemic arterial blood pressure (GO:0003084)3.22719277
52kynurenine metabolic process (GO:0070189)3.18770602
53G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.18765897
54response to auditory stimulus (GO:0010996)3.18704623
55glutamate metabolic process (GO:0006536)3.18122207
56regulation of fatty acid beta-oxidation (GO:0031998)3.16727699
572-oxoglutarate metabolic process (GO:0006103)3.16657681
58aromatic amino acid family catabolic process (GO:0009074)3.14896938
59cysteine metabolic process (GO:0006534)3.11282028
60aspartate family amino acid catabolic process (GO:0009068)3.07664882
61insulin-like growth factor receptor signaling pathway (GO:0048009)3.05469144
62regulation of monocyte differentiation (GO:0045655)3.05097476
63regulation of action potential (GO:0098900)3.04317683
64positive regulation of lipoprotein lipase activity (GO:0051006)3.04054155
65positive regulation of triglyceride lipase activity (GO:0061365)3.04054155
66cellular modified amino acid catabolic process (GO:0042219)3.03581549
67positive regulation of fatty acid beta-oxidation (GO:0032000)3.03534428
68urea cycle (GO:0000050)3.03464627
69urea metabolic process (GO:0019627)3.03464627
70glyoxylate metabolic process (GO:0046487)3.03154189
71sodium ion export (GO:0071436)3.03086642
72fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.02976736
73negative regulation of axon guidance (GO:1902668)3.01362373
74regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.99319914
75negative regulation of fibrinolysis (GO:0051918)2.98768702
76virion attachment to host cell (GO:0019062)2.98301432
77adhesion of symbiont to host cell (GO:0044650)2.98301432
78neurotransmitter secretion (GO:0007269)2.97901441
79bile acid biosynthetic process (GO:0006699)2.97375467
80locomotory exploration behavior (GO:0035641)2.95930611
81cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.93773291
82interferon-gamma secretion (GO:0072643)2.92744978
83high-density lipoprotein particle remodeling (GO:0034375)2.88203617
84regulation of axon extension involved in axon guidance (GO:0048841)2.86446815
85regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.85736476
86regulation of development, heterochronic (GO:0040034)2.85604720
87behavioral response to pain (GO:0048266)2.84248270
88cellular response to ATP (GO:0071318)2.84216228
89cellular ketone body metabolic process (GO:0046950)2.83647175
90fatty acid transmembrane transport (GO:1902001)2.83512678
91negative regulation of cholesterol transport (GO:0032375)2.82292516
92negative regulation of sterol transport (GO:0032372)2.82292516
93adhesion of symbiont to host (GO:0044406)2.82007227
94positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.81382799
95cellular response to electrical stimulus (GO:0071257)2.80966289
96carnitine shuttle (GO:0006853)2.80649630
97cochlea development (GO:0090102)2.79046937
98calcium ion import (GO:0070509)2.78718856
99peptidyl-glutamic acid carboxylation (GO:0017187)2.78199422
100protein carboxylation (GO:0018214)2.78199422
101complement activation, alternative pathway (GO:0006957)2.78099380
102regulation of short-term neuronal synaptic plasticity (GO:0048172)2.78049332
103negative regulation of organelle assembly (GO:1902116)2.77978665
104regulation of triglyceride catabolic process (GO:0010896)2.76847013
105activation of protein kinase A activity (GO:0034199)2.76479420
106negative regulation of peptidyl-serine phosphorylation (GO:0033137)2.75763969
107cytoskeletal anchoring at plasma membrane (GO:0007016)2.75039638
108regulation of axon guidance (GO:1902667)2.74541596
109positive regulation of smoothened signaling pathway (GO:0045880)2.73410015
110macroautophagy (GO:0016236)2.73265493
111regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030947)2.72802372
112nitrogen cycle metabolic process (GO:0071941)2.72440688
113positive regulation of lipid catabolic process (GO:0050996)2.69048524
114negative regulation of protein tyrosine kinase activity (GO:0061099)2.68060333
115reverse cholesterol transport (GO:0043691)2.67710137
116glycerophospholipid catabolic process (GO:0046475)2.67447823
117negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.65972277
118homocysteine metabolic process (GO:0050667)2.65038712
119regulation of fatty acid oxidation (GO:0046320)2.64669339
120cell communication by electrical coupling (GO:0010644)2.64621050
121short-chain fatty acid metabolic process (GO:0046459)2.63947250
122amino-acid betaine metabolic process (GO:0006577)2.63306701
123negative regulation of cell size (GO:0045792)2.62956670
124bile acid metabolic process (GO:0008206)2.62854591
125layer formation in cerebral cortex (GO:0021819)2.62437526
126serine family amino acid catabolic process (GO:0009071)2.62221141
127synaptic transmission, glutamatergic (GO:0035249)2.61398187
128O-glycan processing (GO:0016266)2.60691931
129regulation of protein activation cascade (GO:2000257)2.60494666
130positive regulation of fatty acid oxidation (GO:0046321)2.60429988
131indole-containing compound catabolic process (GO:0042436)2.59541225
132indolalkylamine catabolic process (GO:0046218)2.59541225
133tryptophan catabolic process (GO:0006569)2.59541225
1344-hydroxyproline metabolic process (GO:0019471)2.58532622
135regulation of fibrinolysis (GO:0051917)2.57669207
136dicarboxylic acid catabolic process (GO:0043649)2.56759984
137positive regulation of triglyceride biosynthetic process (GO:0010867)2.56032312
138biotin metabolic process (GO:0006768)2.55964574
139tricarboxylic acid metabolic process (GO:0072350)2.55835638
140positive regulation of triglyceride metabolic process (GO:0090208)2.54845829
141phospholipid homeostasis (GO:0055091)2.54381603
142acetyl-CoA metabolic process (GO:0006084)2.53698837
143alpha-amino acid catabolic process (GO:1901606)2.53615229
144plasma lipoprotein particle clearance (GO:0034381)2.53505442
145regulation of synapse structural plasticity (GO:0051823)2.53349321
146drug catabolic process (GO:0042737)2.52682372
147bone morphogenesis (GO:0060349)2.52324570
148ketone body metabolic process (GO:1902224)2.52141197
149synaptic vesicle docking involved in exocytosis (GO:0016081)2.51287525
150alanine transport (GO:0032328)2.51103386
151activation of MAPKKK activity (GO:0000185)2.50855334
152negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.50715950
153cellular amino acid catabolic process (GO:0009063)2.50636666
154plasma membrane repair (GO:0001778)2.50302917
155acylglycerol homeostasis (GO:0055090)2.50249326
156triglyceride homeostasis (GO:0070328)2.50249326
157regulation of cholesterol metabolic process (GO:0090181)2.50076167
158regulation of ARF protein signal transduction (GO:0032012)2.49636293
159urinary tract smooth muscle contraction (GO:0014848)2.48974233
160oligodendrocyte differentiation (GO:0048709)2.48719536
161cell communication involved in cardiac conduction (GO:0086065)2.47583202
162fatty acid beta-oxidation (GO:0006635)2.46680173
163regulation of complement activation (GO:0030449)2.45256152
164fatty acid homeostasis (GO:0055089)2.44762262
165regulation of mesenchymal cell proliferation (GO:0010464)2.43599413
166mannose metabolic process (GO:0006013)2.41956362
167diaphragm development (GO:0060539)2.41880297
168negative regulation of Rho protein signal transduction (GO:0035024)2.41196215
169axonal fasciculation (GO:0007413)2.41140872
170post-anal tail morphogenesis (GO:0036342)2.41079171
171G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.41000614
172tryptophan metabolic process (GO:0006568)2.40917937
173phospholipid efflux (GO:0033700)2.39866418
174valine metabolic process (GO:0006573)2.38558318
175protein-lipid complex remodeling (GO:0034368)2.38545492
176macromolecular complex remodeling (GO:0034367)2.38545492
177plasma lipoprotein particle remodeling (GO:0034369)2.38545492
178positive regulation of fatty acid biosynthetic process (GO:0045723)2.38340609
179regulation of protein kinase C signaling (GO:0090036)2.37633674
180dopamine receptor signaling pathway (GO:0007212)2.37143684
181acylglycerol catabolic process (GO:0046464)2.35957536
182neutral lipid catabolic process (GO:0046461)2.35957536
183cerebellar Purkinje cell layer development (GO:0021680)2.35199139
184negative regulation of lipid transport (GO:0032369)2.34940701
185ethanol oxidation (GO:0006069)2.34759062
186regulation of lipid catabolic process (GO:0050994)2.34365740
187glutamate secretion (GO:0014047)2.33219831

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.06373563
2RXR_22158963_ChIP-Seq_LIVER_Mouse3.76335097
3PPARA_22158963_ChIP-Seq_LIVER_Mouse3.33659788
4PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.24096155
5LXR_22158963_ChIP-Seq_LIVER_Mouse3.13391837
6SRY_22984422_ChIP-ChIP_TESTIS_Rat3.05256444
7NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.54097201
8TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.51290899
9FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.47994711
10EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.25822253
11RCOR2_21632747_ChIP-Seq_MESCs_Mouse2.25081252
12JARID2_20064375_ChIP-Seq_MESCs_Mouse2.24890289
13TP63_17297297_ChIP-ChIP_HaCaT_Human2.09049321
14LXR_22292898_ChIP-Seq_THP-1_Human1.98343957
15MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.97212843
16ZNF263_19887448_ChIP-Seq_K562_Human1.97139155
17TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.94465400
18THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.88621821
19CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.85950402
20SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.85353673
21TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.83352800
22KDM2B_26808549_Chip-Seq_K562_Human1.82538155
23TP53_20018659_ChIP-ChIP_R1E_Mouse1.82131074
24EZH2_27304074_Chip-Seq_ESCs_Mouse1.80324958
25RARB_27405468_Chip-Seq_BRAIN_Mouse1.78379385
26DROSHA_22980978_ChIP-Seq_HELA_Human1.76017887
27KDM2B_26808549_Chip-Seq_SUP-B15_Human1.73980905
28ERG_21242973_ChIP-ChIP_JURKAT_Human1.73969532
29ESR2_21235772_ChIP-Seq_MCF-7_Human1.73123387
30NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.64759572
31CLOCK_20551151_ChIP-Seq_293T_Human1.62045157
32ZFP281_18757296_ChIP-ChIP_E14_Mouse1.61751055
33EED_16625203_ChIP-ChIP_MESCs_Mouse1.60568317
34VDR_21846776_ChIP-Seq_THP-1_Human1.60267576
35EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.58669081
36DNAJC2_21179169_ChIP-ChIP_NT2_Human1.58254166
37KDM2B_26808549_Chip-Seq_DND41_Human1.57482251
38ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.54536251
39TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.52573394
40SA1_27219007_Chip-Seq_ERYTHROID_Human1.50040856
41ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.47914888
42RARG_19884340_ChIP-ChIP_MEFs_Mouse1.47855764
43FOXA2_19822575_ChIP-Seq_HepG2_Human1.47851083
44SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.42775656
45TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.40442841
46RACK7_27058665_Chip-Seq_MCF-7_Human1.38590879
47CREB1_26743006_Chip-Seq_LNCaP_Human1.35545340
48WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.34159957
49MTF2_20144788_ChIP-Seq_MESCs_Mouse1.34003283
50SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.33920483
51EZH2_22144423_ChIP-Seq_EOC_Human1.30561596
52CTCF_27219007_Chip-Seq_ERYTHROID_Human1.30295471
53CTCF_20526341_ChIP-Seq_ESCs_Human1.29558789
54GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.28303777
55STAT6_21828071_ChIP-Seq_BEAS2B_Human1.27207258
56SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.25786807
57NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.25067190
58KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.24334116
59CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.24201114
60PHF8_20622854_ChIP-Seq_HELA_Human1.23598404
61ZFP281_27345836_Chip-Seq_ESCs_Mouse1.23213615
62SMC3_22415368_ChIP-Seq_MEFs_Mouse1.23194796
63PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.22532537
64EZH2_18974828_ChIP-Seq_MESCs_Mouse1.22528008
65RNF2_18974828_ChIP-Seq_MESCs_Mouse1.22528008
66ESR1_15608294_ChIP-ChIP_MCF-7_Human1.21406272
67KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.20736979
68TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.20641598
69KDM2B_26808549_Chip-Seq_JURKAT_Human1.20623724
70P300_27058665_Chip-Seq_ZR-75-30cells_Human1.20460196
71DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.19979968
72GATA1_19941826_ChIP-Seq_K562_Human1.19886877
73OCT4_19829295_ChIP-Seq_ESCs_Human1.19525128
74TET1_21451524_ChIP-Seq_MESCs_Mouse1.18742852
75ESR1_20079471_ChIP-ChIP_T-47D_Human1.16967152
76TBX20_22328084_ChIP-Seq_HEART_Mouse1.16813626
77TBX20_22080862_ChIP-Seq_HEART_Mouse1.16813626
78CTCF_27219007_Chip-Seq_Bcells_Human1.16563402
79TCF7_22412390_ChIP-Seq_EML_Mouse1.15435718
80SMC4_20622854_ChIP-Seq_HELA_Human1.15147859
81EGR1_23403033_ChIP-Seq_LIVER_Mouse1.14819795
82RING1B_27294783_Chip-Seq_ESCs_Mouse1.13880694
83MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.13610672
84PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.12668896
85CBX2_27304074_Chip-Seq_ESCs_Mouse1.11692960
86REST_18959480_ChIP-ChIP_MESCs_Mouse1.10889813
87BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.10172080
88EZH2_27294783_Chip-Seq_ESCs_Mouse1.09260161
89E2F1_20622854_ChIP-Seq_HELA_Human1.09133774
90SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.09107321
91ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.09070611
92SUZ12_27294783_Chip-Seq_ESCs_Mouse1.08646670
93P68_20966046_ChIP-Seq_HELA_Human1.08394791
94SOX2_27498859_Chip-Seq_STOMACH_Mouse1.08270536
95WT1_25993318_ChIP-Seq_PODOCYTE_Human1.08253282
96ELF1_20517297_ChIP-Seq_JURKAT_Human1.08095174
97BCOR_27268052_Chip-Seq_Bcells_Human1.07206561
98JARID2_20075857_ChIP-Seq_MESCs_Mouse1.06999831
99ELK3_25401928_ChIP-Seq_HUVEC_Human1.06812136
100SA1_27219007_Chip-Seq_Bcells_Human1.06516148
101REST_21632747_ChIP-Seq_MESCs_Mouse1.05725896
102SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.05376750
103PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.04926648
104BCL6_27268052_Chip-Seq_Bcells_Human1.04918789
105ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.03498877
106RAD21_21589869_ChIP-Seq_MESCs_Mouse1.03149760
107SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02923920
108CTCF_26484167_Chip-Seq_Bcells_Mouse1.02015726
109RING1B_27294783_Chip-Seq_NPCs_Mouse1.01724097
110PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.01687148
111RUNX1_27514584_Chip-Seq_MCF-7_Human1.00993101
112TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.00310975
113SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.00228001
114AR_21572438_ChIP-Seq_LNCaP_Human0.99435802
115MYC_27129775_Chip-Seq_CORNEA_Mouse0.99288089
116STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.98435894
117KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.97158598
118TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.97054588
119FOXO3_23340844_ChIP-Seq_DLD1_Human0.96684953
120SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.96207082
121TP63_22573176_ChIP-Seq_HFKS_Human0.94299934
122TET1_21490601_ChIP-Seq_MESCs_Mouse0.91613283
123ESR1_21235772_ChIP-Seq_MCF-7_Human0.91419550
124UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.91327658
125GATA1_22025678_ChIP-Seq_K562_Human0.91071591
126TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.90911044
127KLF4_19829295_ChIP-Seq_ESCs_Human0.90553147
128CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.88001690
129ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.87804003
130SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.87210289
131RNF2_27304074_Chip-Seq_ESCs_Mouse0.86662882
132ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.86513733
133ATF3_27146783_Chip-Seq_COLON_Human0.86407528
134GATA1_19941827_ChIP-Seq_MEL_Mouse0.85775296
135KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.85561407
136EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.84156982
137RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.84110428
138ZNF217_24962896_ChIP-Seq_MCF-7_Human0.84100812
139GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.83970636
140SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.83135770
141TRIM28_21343339_ChIP-Seq_HEK293_Human0.82666007
142HNF4A_19822575_ChIP-Seq_HepG2_Human0.82361828

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000566_synostosis9.17860715
2MP0002139_abnormal_hepatobiliary_system4.78940086
3MP0005360_urolithiasis4.45061952
4MP0005365_abnormal_bile_salt3.77927505
5MP0005085_abnormal_gallbladder_physiolo3.77913797
6MP0005423_abnormal_somatic_nervous3.65448993
7MP0004859_abnormal_synaptic_plasticity3.15593651
8MP0003705_abnormal_hypodermis_morpholog3.03792004
9MP0003252_abnormal_bile_duct2.78198478
10MP0008875_abnormal_xenobiotic_pharmacok2.60774000
11MP0010329_abnormal_lipoprotein_level2.52034734
12MP0005083_abnormal_biliary_tract2.46536258
13MP0009840_abnormal_foam_cell2.40106689
14MP0002909_abnormal_adrenal_gland2.36706152
15MP0002837_dystrophic_cardiac_calcinosis2.29662963
16MP0009780_abnormal_chondrocyte_physiolo2.22841406
17MP0002249_abnormal_larynx_morphology2.21949941
18MP0003880_abnormal_central_pattern2.17368279
19MP0004130_abnormal_muscle_cell2.16362590
20MP0010234_abnormal_vibrissa_follicle2.13682765
21MP0008961_abnormal_basal_metabolism2.09642258
22MP0005646_abnormal_pituitary_gland2.08059398
23MP0000462_abnormal_digestive_system1.97569424
24MP0003283_abnormal_digestive_organ1.96818683
25MP0001666_abnormal_nutrient_absorption1.94179030
26MP0003195_calcinosis1.89842094
27MP0002822_catalepsy1.89044604
28MP0003329_amyloid_beta_deposits1.84410770
29MP0009046_muscle_twitch1.82815823
30MP0005332_abnormal_amino_acid1.76240631
31MP0002272_abnormal_nervous_system1.74851268
32MP0000751_myopathy1.73188207
33MP0003191_abnormal_cellular_cholesterol1.69427122
34MP0002118_abnormal_lipid_homeostasis1.69223628
35MP0002733_abnormal_thermal_nociception1.68974565
36MP0005595_abnormal_vascular_smooth1.60572676
37MP0004134_abnormal_chest_morphology1.60377584
38MP0004858_abnormal_nervous_system1.57784733
39MP0002734_abnormal_mechanical_nocicepti1.56350538
40MP0005171_absent_coat_pigmentation1.52102803
41MP0008995_early_reproductive_senescence1.49756745
42MP0003635_abnormal_synaptic_transmissio1.49469825
43MP0001970_abnormal_pain_threshold1.48607801
44MP0004270_analgesia1.48096361
45MP0004043_abnormal_pH_regulation1.47457672
46MP0001968_abnormal_touch/_nociception1.47023862
47MP0005257_abnormal_intraocular_pressure1.42948203
48MP0002572_abnormal_emotion/affect_behav1.42899269
49MP0002735_abnormal_chemical_nociception1.42020978
50MP0003123_paternal_imprinting1.41357008
51MP0000609_abnormal_liver_physiology1.40157301
52MP0003300_gastrointestinal_ulcer1.39674195
53MP0003453_abnormal_keratinocyte_physiol1.38765933
54MP0000013_abnormal_adipose_tissue1.36799150
55MP0005666_abnormal_adipose_tissue1.35616056
56MP0000678_abnormal_parathyroid_gland1.35567413
57MP0003136_yellow_coat_color1.33974762
58MP0003806_abnormal_nucleotide_metabolis1.30405111
59MP0001440_abnormal_grooming_behavior1.29589121
60MP0000604_amyloidosis1.29025268
61MP0004185_abnormal_adipocyte_glucose1.28850927
62MP0001485_abnormal_pinna_reflex1.25773576
63MP0002078_abnormal_glucose_homeostasis1.24356644
64MP0001486_abnormal_startle_reflex1.24272415
65MP0005375_adipose_tissue_phenotype1.23401552
66MP0005508_abnormal_skeleton_morphology1.22849097
67MP0005670_abnormal_white_adipose1.21885001
68MP0000003_abnormal_adipose_tissue1.21234790
69MP0002089_abnormal_postnatal_growth/wei1.20931317
70MP0002269_muscular_atrophy1.19971142
71MP0003075_altered_response_to1.19805801
72MP0000747_muscle_weakness1.17243843
73MP0004036_abnormal_muscle_relaxation1.16563256
74MP0005167_abnormal_blood-brain_barrier1.16482455
75MP0005319_abnormal_enzyme/_coenzyme1.16335175
76MP0004087_abnormal_muscle_fiber1.15382762
77MP0005584_abnormal_enzyme/coenzyme_acti1.14106725
78MP0005058_abnormal_lysosome_morphology1.13606757
79MP0002932_abnormal_joint_morphology1.12347308
80MP0004084_abnormal_cardiac_muscle1.11826625
81MP0000049_abnormal_middle_ear1.10954629
82MP0002877_abnormal_melanocyte_morpholog1.10039369
83MP0002063_abnormal_learning/memory/cond1.09035722
84MP0005535_abnormal_body_temperature1.08449408
85MP0003868_abnormal_feces_composition1.08304312
86MP0004019_abnormal_vitamin_homeostasis1.07388486
87MP0005330_cardiomyopathy1.05512036
88MP0009643_abnormal_urine_homeostasis1.04033275
89MP0010030_abnormal_orbit_morphology1.01925089
90MP0001299_abnormal_eye_distance/0.98401940
91MP0000569_abnormal_digit_pigmentation0.97700958
92MP0004885_abnormal_endolymph0.95651198
93MP0004145_abnormal_muscle_electrophysio0.95433704
94MP0000733_abnormal_muscle_development0.95413398
95MP0001765_abnormal_ion_homeostasis0.95258722
96MP0003646_muscle_fatigue0.95057780
97MP0002971_abnormal_brown_adipose0.92309598
98MP0005187_abnormal_penis_morphology0.91922981
99MP0002234_abnormal_pharynx_morphology0.91834679
100MP0003045_fibrosis0.91150986
101MP0004381_abnormal_hair_follicle0.89765073
102MP0001502_abnormal_circadian_rhythm0.89552099
103MP0003633_abnormal_nervous_system0.85511135
104MP0002138_abnormal_hepatobiliary_system0.85250022
105MP0009745_abnormal_behavioral_response0.85119738
106MP0004233_abnormal_muscle_weight0.84708286
107MP0003690_abnormal_glial_cell0.84054850
108MP0002064_seizures0.83755698
109MP0005174_abnormal_tail_pigmentation0.83664921
110MP0004782_abnormal_surfactant_physiolog0.83478482
111MP0005448_abnormal_energy_balance0.83145722
112MP0001348_abnormal_lacrimal_gland0.82968627
113MP0003183_abnormal_peptide_metabolism0.82677658
114MP0001944_abnormal_pancreas_morphology0.82287530
115MP0001756_abnormal_urination0.82060813
116MP0003879_abnormal_hair_cell0.81903008
117MP0008874_decreased_physiological_sensi0.81679152
118MP0002116_abnormal_craniofacial_bone0.81663251
119MP0004924_abnormal_behavior0.81210051
120MP0005386_behavior/neurological_phenoty0.81210051
121MP0002557_abnormal_social/conspecific_i0.81071250
122MP0002067_abnormal_sensory_capabilities0.80184865
123MP0004215_abnormal_myocardial_fiber0.79749429
124MP0001664_abnormal_digestion0.78806261
125MP0005409_darkened_coat_color0.78054915
126MP0004085_abnormal_heartbeat0.77783773
127MP0000026_abnormal_inner_ear0.77163944
128MP0002184_abnormal_innervation0.75541817
129MP0005620_abnormal_muscle_contractility0.75130516
130MP0002066_abnormal_motor_capabilities/c0.75044363
131MP0003656_abnormal_erythrocyte_physiolo0.74825981
132MP0008569_lethality_at_weaning0.74344046
133MP0001849_ear_inflammation0.74233182
134MP0005334_abnormal_fat_pad0.74156361
135MP0001963_abnormal_hearing_physiology0.74016577
136MP0009384_cardiac_valve_regurgitation0.72594032
137MP0003953_abnormal_hormone_level0.72435325
138MP0000749_muscle_degeneration0.72404480
139MP0002896_abnormal_bone_mineralization0.71305948
140MP0010630_abnormal_cardiac_muscle0.71271426
141MP0003755_abnormal_palate_morphology0.68525232
142MP0009931_abnormal_skin_appearance0.67939373
143MP0003172_abnormal_lysosome_physiology0.67889843
144MP0004811_abnormal_neuron_physiology0.67841181
145MP0010368_abnormal_lymphatic_system0.67742432
146MP0002098_abnormal_vibrissa_morphology0.67238468
147MP0000759_abnormal_skeletal_muscle0.66444454
148MP0006138_congestive_heart_failure0.65863441
149MP0004510_myositis0.65851840
150MP0003137_abnormal_impulse_conducting0.65609781
151MP0003115_abnormal_respiratory_system0.65341442
152MP0003634_abnormal_glial_cell0.64769421
153MP0000428_abnormal_craniofacial_morphol0.63664749
154MP0004133_heterotaxia0.63105242
155MP0000383_abnormal_hair_follicle0.63079032
156MP0002069_abnormal_eating/drinking_beha0.62589606
157MP0005381_digestive/alimentary_phenotyp0.62267337
158MP0004264_abnormal_extraembryonic_tissu0.61537381
159MP0000579_abnormal_nail_morphology0.61276933
160MP0002972_abnormal_cardiac_muscle0.60754520
161MP0000598_abnormal_liver_morphology0.60376292
162MP0005166_decreased_susceptibility_to0.60243663
163MP0002796_impaired_skin_barrier0.60151226
164MP0001958_emphysema0.58977686
165MP0000762_abnormal_tongue_morphology0.58190085
166MP0001340_abnormal_eyelid_morphology0.57935607
167MP0002111_abnormal_tail_morphology0.56578560
168MP0000163_abnormal_cartilage_morphology0.56155975
169MP0000778_abnormal_nervous_system0.55713130
170MP0000470_abnormal_stomach_morphology0.55623496
171MP0003787_abnormal_imprinting0.54625421
172MP0000538_abnormal_urinary_bladder0.53637393

Predicted human phenotypes

RankGene SetZ-score
1Bradycardia (HP:0001662)6.96575835
2Synostosis involving the elbow (HP:0003938)5.04918583
3Humeroradial synostosis (HP:0003041)5.04918583
4Atonic seizures (HP:0010819)4.30801415
5Deep venous thrombosis (HP:0002625)4.25321248
6Atrial fibrillation (HP:0005110)3.67496860
7Xanthomatosis (HP:0000991)3.58876671
8Ulnar claw (HP:0001178)3.50254219
9Primary atrial arrhythmia (HP:0001692)3.42685829
10Ketoacidosis (HP:0001993)3.42329350
11Ketosis (HP:0001946)3.41212132
12Abnormality of aromatic amino acid family metabolism (HP:0004338)3.36516370
13Supraventricular tachycardia (HP:0004755)3.34994515
14Intrahepatic cholestasis (HP:0001406)3.30124431
15Supraventricular arrhythmia (HP:0005115)3.25532696
16Difficulty climbing stairs (HP:0003551)3.24168867
17Abnormality of the aortic arch (HP:0012303)3.23182682
18Symphalangism affecting the phalanges of the hand (HP:0009773)3.12597002
19Abnormality of the lower motor neuron (HP:0002366)3.08867098
20Hypoglycemic coma (HP:0001325)3.05599160
21Febrile seizures (HP:0002373)3.04574501
22Absence seizures (HP:0002121)3.04420204
23Abnormality of monocarboxylic acid metabolism (HP:0010996)3.03168481
24Gout (HP:0001997)2.87964658
25Amblyopia (HP:0000646)2.85575866
26Complement deficiency (HP:0004431)2.82807954
27Epileptic encephalopathy (HP:0200134)2.79319388
28Neoplasm of the heart (HP:0100544)2.78569083
29Obstructive sleep apnea (HP:0002870)2.78162217
30Flat capital femoral epiphysis (HP:0003370)2.77261197
31Mildly elevated creatine phosphokinase (HP:0008180)2.76459048
32Hyperlipoproteinemia (HP:0010980)2.71312659
33Inability to walk (HP:0002540)2.70195680
34J-shaped sella turcica (HP:0002680)2.69883333
35Bundle branch block (HP:0011710)2.66898031
36Hyperinsulinemic hypoglycemia (HP:0000825)2.63285357
37Abnormality of the Achilles tendon (HP:0005109)2.60559689
38Hyperammonemia (HP:0001987)2.59674506
39Focal seizures (HP:0007359)2.59627507
40Hypoalphalipoproteinemia (HP:0003233)2.58877172
41Akinesia (HP:0002304)2.57642817
42Myoglobinuria (HP:0002913)2.51397580
43Exercise-induced myalgia (HP:0003738)2.50653473
44Gaze-evoked nystagmus (HP:0000640)2.48131423
45Menstrual irregularities (HP:0000858)2.47875506
46Epidermoid cyst (HP:0200040)2.46537207
47Hyperglycinuria (HP:0003108)2.44832321
48Abnormality of glycolipid metabolism (HP:0010969)2.44829270
49Abnormality of liposaccharide metabolism (HP:0010968)2.44829270
50Abnormality of glycosphingolipid metabolism (HP:0004343)2.44829270
51Ventricular fibrillation (HP:0001663)2.43368495
52Truncal ataxia (HP:0002078)2.43365866
53Stridor (HP:0010307)2.41326189
54Hypoventilation (HP:0002791)2.40661749
55Morphological abnormality of the middle ear (HP:0008609)2.40109566
56Turricephaly (HP:0000262)2.39971940
57Hypothermia (HP:0002045)2.39693522
58Visceral angiomatosis (HP:0100761)2.39670277
59Thin bony cortex (HP:0002753)2.39035831
60Annular pancreas (HP:0001734)2.36930304
61Myokymia (HP:0002411)2.35157582
62Upper limb amyotrophy (HP:0009129)2.32848736
63Distal upper limb amyotrophy (HP:0007149)2.32848736
64Dysostosis multiplex (HP:0000943)2.32806490
65Achilles tendon contracture (HP:0001771)2.32690875
66Abnormality of glutamine family amino acid metabolism (HP:0010902)2.32370769
67Skin nodule (HP:0200036)2.32279154
68Sudden death (HP:0001699)2.31737775
69Late onset (HP:0003584)2.31302208
70Spinal muscular atrophy (HP:0007269)2.30683224
71Neurofibrillary tangles (HP:0002185)2.28786388
72Hydroxyprolinuria (HP:0003080)2.27719908
73Abnormality of proline metabolism (HP:0010907)2.27719908
74Abnormality of the common coagulation pathway (HP:0010990)2.26355853
75Abnormality of serine family amino acid metabolism (HP:0010894)2.26118924
76Abnormality of glycine metabolism (HP:0010895)2.26118924
77Hypobetalipoproteinemia (HP:0003563)2.25971364
78Hypolipoproteinemia (HP:0010981)2.25351147
79Dysmetria (HP:0001310)2.25339995
80Increased neuronal autofluorescent lipopigment (HP:0002074)2.24279487
81Focal motor seizures (HP:0011153)2.23796624
82Dysmetric saccades (HP:0000641)2.23618677
83Visual hallucinations (HP:0002367)2.23184583
84Lymphangioma (HP:0100764)2.23165306
85Difficulty running (HP:0009046)2.21703663
86Hyporeflexia of lower limbs (HP:0002600)2.20545672
87Right ventricular cardiomyopathy (HP:0011663)2.19984386
88Mesangial abnormality (HP:0001966)2.19169056
89Cerebral aneurysm (HP:0004944)2.18326473
90Increased cerebral lipofuscin (HP:0011813)2.17611653
91Hypoglycemic seizures (HP:0002173)2.16890791
92Hemangiomatosis (HP:0007461)2.16837596
93Broad face (HP:0000283)2.16177949
94Hyperglycinemia (HP:0002154)2.14200563
95Atrioventricular block (HP:0001678)2.12926033
96Congenital stationary night blindness (HP:0007642)2.10508222
97Cholelithiasis (HP:0001081)2.10034153
98Insomnia (HP:0100785)2.09777549
99Neonatal onset (HP:0003623)2.09096516
100Hyperglycemia (HP:0003074)2.07961269
101Asymmetric septal hypertrophy (HP:0001670)2.06824232
102Abnormality of purine metabolism (HP:0004352)2.05830085
103Self-mutilation (HP:0000742)2.05101122
104Global brain atrophy (HP:0002283)2.05092585
105Severe muscular hypotonia (HP:0006829)2.03936434
106Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.03078092
107Cerebral inclusion bodies (HP:0100314)2.03039067
108Abnormality of the intrinsic pathway (HP:0010989)2.02985240
109Hand muscle atrophy (HP:0009130)2.02805251
110Long toe (HP:0010511)2.02514248
111Abnormality of the humeroradial joint (HP:0100744)2.01499146
112Aplasia involving bones of the upper limbs (HP:0009823)2.00643627
113Aplasia of the phalanges of the hand (HP:0009802)2.00643627
114Aplasia involving bones of the extremities (HP:0009825)2.00643627
115Heart block (HP:0012722)1.99213267
116Impaired social interactions (HP:0000735)1.99001934
117Abnormal social behavior (HP:0012433)1.99001934
118Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.98829392
119Abnormal gallbladder morphology (HP:0012437)1.98282089
120Dialeptic seizures (HP:0011146)1.98182716
121Ulnar bowing (HP:0003031)1.98049749
122Abnormality of complement system (HP:0005339)1.97545364
123Status epilepticus (HP:0002133)1.97220564
124Polycythemia (HP:0001901)1.96681334
125Hyperacusis (HP:0010780)1.96670510
126Large for gestational age (HP:0001520)1.95915055
127Back pain (HP:0003418)1.95307853
128Concave nail (HP:0001598)1.95100975
129Abnormality of the sella turcica (HP:0002679)1.94678892
130Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.94648970
131Torticollis (HP:0000473)1.94044592
132Hypopigmentation of the fundus (HP:0007894)1.92859676
133Resting tremor (HP:0002322)1.92780336
134Aortic regurgitation (HP:0001659)1.92300053
135Abnormality of sulfur amino acid metabolism (HP:0004339)1.91828546
136Exercise-induced muscle cramps (HP:0003710)1.91281711
137Palpebral edema (HP:0100540)1.90516102
138Joint stiffness (HP:0001387)1.90474016
139Action tremor (HP:0002345)1.89408808
140Abnormal atrioventricular conduction (HP:0005150)1.89385849
141Abnormal hair laboratory examination (HP:0003328)1.88938615
142Prolonged partial thromboplastin time (HP:0003645)1.87978853
143Difficulty walking (HP:0002355)1.85901287
144Postural instability (HP:0002172)1.85703928
145Abnormality of endocrine pancreas physiology (HP:0012093)1.85703117
146Abnormality of the pancreatic islet cells (HP:0006476)1.85703117
147Supranuclear gaze palsy (HP:0000605)1.85388995
148Nuclear cataract (HP:0100018)1.85257376
149Depression (HP:0000716)1.83974385
150Delayed CNS myelination (HP:0002188)1.83658554
151Hemiplegia (HP:0002301)1.83429653
152Increased connective tissue (HP:0009025)1.82385329
153Aneurysm (HP:0002617)1.82328121
154Macroorchidism (HP:0000053)1.82069719
155Enlarged penis (HP:0000040)1.80673267
156Hypercholesterolemia (HP:0003124)1.80362825
157Sensorimotor neuropathy (HP:0007141)1.78130481
158Hamartoma of the eye (HP:0010568)1.78105333
159Septo-optic dysplasia (HP:0100842)1.77418468
160Reticulocytosis (HP:0001923)1.76961693
161Abnormality of polysaccharide metabolism (HP:0011012)1.76884507
162Abnormality of glycosaminoglycan metabolism (HP:0004371)1.76884507
163Abnormality of mucopolysaccharide metabolism (HP:0011020)1.76884507
164Malnutrition (HP:0004395)1.76441379
165Spastic diplegia (HP:0001264)1.74642464
166Bulbous nose (HP:0000414)1.74401142
167Abnormality of fatty-acid metabolism (HP:0004359)1.73298460
168Synostosis involving bones of the hand (HP:0004278)1.73224334
169Shallow orbits (HP:0000586)1.72348228
170Ventricular arrhythmia (HP:0004308)1.70801579
171Broad metatarsal (HP:0001783)1.70348516
172Renal cell carcinoma (HP:0005584)1.69868725
173Myocardial infarction (HP:0001658)1.69782041
174Elfin facies (HP:0004428)1.69534984
175EMG: neuropathic changes (HP:0003445)1.69420402
176Intention tremor (HP:0002080)1.68962701
177Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.68908191
178Hyperbilirubinemia (HP:0002904)1.68457797
179Mucopolysacchariduria (HP:0008155)1.67090227
180Urinary glycosaminoglycan excretion (HP:0003541)1.67090227
181Anosmia (HP:0000458)1.66999545
182Cervical subluxation (HP:0003308)1.66733958
183Pointed chin (HP:0000307)1.65727479
184Abnormal eating behavior (HP:0100738)1.65299383

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.41078170
2TNK23.13946164
3PKN23.01360597
4ERN12.62181322
5PRKD32.56727873
6RIPK12.43978068
7MAP3K92.33989223
8SMG12.27794222
9DAPK22.17016296
10EPHA22.14883705
11SIK12.14409552
12KSR22.06808627
13BCKDK1.89058924
14EPHA41.75070155
15IRAK31.74887996
16CAMKK11.73260163
17TAOK11.70268766
18PDGFRA1.69189760
19PAK61.67778579
20PTK61.65965476
21ICK1.58864131
22NTRK31.54790970
23TTN1.54152594
24MAPK151.53251694
25LMTK21.46203503
26MAP3K21.46057009
27STK381.42193785
28CAMK2G1.39771964
29MAP3K101.37600338
30MAP2K41.37587012
31NTRK11.36347687
32TYRO31.33942782
33FGFR41.32882506
34INSRR1.32392797
35EEF2K1.31775316
36RET1.31515375
37MAP3K71.31498523
38MUSK1.24539994
39PRKCH1.23996763
40PHKG11.20409378
41PHKG21.20409378
42MAP3K41.12018344
43NEK11.11439498
44MAP4K11.11284319
45MAP3K11.08953252
46CAMK1G1.07060116
47RPS6KA61.06557763
48BMX1.04640391
49LATS21.03119161
50ALK1.02173928
51LATS10.98822703
52RPS6KL10.98119307
53RPS6KC10.98119307
54PDK30.97096127
55PDK40.97096127
56SIK20.96864745
57MINK10.96554071
58TAOK30.96344577
59DMPK0.92895524
60SCYL20.92430781
61PAK30.91959895
62PTK20.91253462
63PINK10.91155056
64PDPK10.89688556
65CAMK2B0.89492803
66PRPF4B0.87117108
67SGK30.85488682
68CAMK1D0.85401912
69DDR20.84512994
70MAP2K60.84065900
71MARK10.83167060
72PDK10.77062976
73CDC42BPA0.75710814
74STK110.74279842
75PRKCG0.74198773
76TESK10.72664436
77MTOR0.72291096
78PRKAA10.72113247
79MARK20.71993013
80CDK50.71895104
81KSR10.71412889
82JAK20.71209594
83FER0.71070360
84PRKD10.70418818
85WNK40.66556232
86NTRK20.65724695
87DYRK1B0.65277518
88ABL20.63857137
89EPHB10.63623356
90FGFR20.62675822
91MAP3K110.60711706
92MAP2K10.60176559
93UHMK10.59856816
94NME10.59774225
95CAMK40.57734452
96DAPK10.56908988
97IRAK20.55783538
98PRKD20.55725771
99JAK10.55273448
100CHUK0.55214857
101PDGFRB0.55087059
102PRKG20.53754647
103MAP2K20.52568174
104PRKCZ0.51531944
105WNK10.50936105
106MST1R0.50759185
107ERBB20.50245454
108MELK0.50111789
109MAPK110.48989733
110DAPK30.45537117
111MAPK120.45311381
112RPS6KA20.45271937
113FRK0.45135050
114HIPK20.44850993
115STK160.44559429
116PTK2B0.44429362
117RPS6KA30.44280845
118LRRK20.44138189
119CAMK10.44080886
120MAPKAPK30.44023172
121PRKAA20.43660411
122RPS6KA10.43361722
123PRKACG0.42152598
124MAP3K130.41139089
125SGK4940.40778446
126SGK2230.40778446
127MAPK80.40578845
128CSNK1A10.39527164
129PRKCI0.37468315
130CAMK2D0.37199868
131MAPKAPK20.36954323
132MAP3K30.36919543
133MAPK40.31764342
134ZAP700.31644903
135ADRBK20.30513938
136CDK150.29382522
137TXK0.29104875
138EPHB20.28407683
139GRK10.28104152
140SRC0.28074592

Predicted pathways (KEGG)

RankGene SetZ-score
1Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005124.96569856
2Nitrogen metabolism_Homo sapiens_hsa009103.97397065
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.05870996
4Nicotine addiction_Homo sapiens_hsa050332.68070937
5Primary bile acid biosynthesis_Homo sapiens_hsa001202.56617676
6Arginine biosynthesis_Homo sapiens_hsa002202.48673298
7Fatty acid degradation_Homo sapiens_hsa000711.99221622
82-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.95417247
9Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.92861080
10Taste transduction_Homo sapiens_hsa047421.86244544
11Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.85283872
12Bile secretion_Homo sapiens_hsa049761.81827560
13Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.77761718
14Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.75547709
15Butanoate metabolism_Homo sapiens_hsa006501.75192947
16Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.72300150
17Tryptophan metabolism_Homo sapiens_hsa003801.72148525
18PPAR signaling pathway_Homo sapiens_hsa033201.57490504
19Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.57427837
20Fatty acid metabolism_Homo sapiens_hsa012121.53648489
21Propanoate metabolism_Homo sapiens_hsa006401.52328945
22Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.48709597
23Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.43317138
24Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.43076384
25Maturity onset diabetes of the young_Homo sapiens_hsa049501.33048934
26Melanoma_Homo sapiens_hsa052181.27562261
27Calcium signaling pathway_Homo sapiens_hsa040201.25384381
28Type II diabetes mellitus_Homo sapiens_hsa049301.21981108
29Complement and coagulation cascades_Homo sapiens_hsa046101.21409068
30Other glycan degradation_Homo sapiens_hsa005111.20237568
31Insulin secretion_Homo sapiens_hsa049111.14143724
32Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.13169310
33Ovarian steroidogenesis_Homo sapiens_hsa049131.12022021
34Fat digestion and absorption_Homo sapiens_hsa049751.11736598
35Axon guidance_Homo sapiens_hsa043601.05923639
36Lysosome_Homo sapiens_hsa041421.02388066
37Carbon metabolism_Homo sapiens_hsa012001.01450022
38Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.99629298
39Lysine degradation_Homo sapiens_hsa003100.99627892
40Aldosterone synthesis and secretion_Homo sapiens_hsa049250.98785569
41Insulin resistance_Homo sapiens_hsa049310.98621799
42Pyruvate metabolism_Homo sapiens_hsa006200.98243387
43Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.96633853
44beta-Alanine metabolism_Homo sapiens_hsa004100.96444988
45Sphingolipid metabolism_Homo sapiens_hsa006000.95739381
46Glycosaminoglycan degradation_Homo sapiens_hsa005310.95189356
47Starch and sucrose metabolism_Homo sapiens_hsa005000.94956639
48Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.93836546
49Biosynthesis of amino acids_Homo sapiens_hsa012300.93584988
50Vitamin B6 metabolism_Homo sapiens_hsa007500.92376136
51Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.92075232
52Inositol phosphate metabolism_Homo sapiens_hsa005620.91367118
53Gastric acid secretion_Homo sapiens_hsa049710.90321042
54Caffeine metabolism_Homo sapiens_hsa002320.89913552
55Glucagon signaling pathway_Homo sapiens_hsa049220.89550170
56Fatty acid biosynthesis_Homo sapiens_hsa000610.88484204
57ABC transporters_Homo sapiens_hsa020100.88172568
58Carbohydrate digestion and absorption_Homo sapiens_hsa049730.87814538
59Synaptic vesicle cycle_Homo sapiens_hsa047210.87191760
60Pentose and glucuronate interconversions_Homo sapiens_hsa000400.86454004
61Glycerolipid metabolism_Homo sapiens_hsa005610.84485316
62Peroxisome_Homo sapiens_hsa041460.84411565
63Phospholipase D signaling pathway_Homo sapiens_hsa040720.84105060
64MAPK signaling pathway_Homo sapiens_hsa040100.83830326
65Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.82364368
66Adipocytokine signaling pathway_Homo sapiens_hsa049200.81959315
67GABAergic synapse_Homo sapiens_hsa047270.81889063
68Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.81887911
69ECM-receptor interaction_Homo sapiens_hsa045120.80771613
70Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.79041382
71Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.78750773
72Rap1 signaling pathway_Homo sapiens_hsa040150.78385307
73Notch signaling pathway_Homo sapiens_hsa043300.78151115
74Salivary secretion_Homo sapiens_hsa049700.77355341
75Long-term potentiation_Homo sapiens_hsa047200.77246524
76Vascular smooth muscle contraction_Homo sapiens_hsa042700.76692539
77Bladder cancer_Homo sapiens_hsa052190.76665759
78Circadian entrainment_Homo sapiens_hsa047130.76451441
79Olfactory transduction_Homo sapiens_hsa047400.76213551
80Phenylalanine metabolism_Homo sapiens_hsa003600.75483612
81Melanogenesis_Homo sapiens_hsa049160.75444389
82Ras signaling pathway_Homo sapiens_hsa040140.75419877
83Selenocompound metabolism_Homo sapiens_hsa004500.75253067
84Linoleic acid metabolism_Homo sapiens_hsa005910.75103359
85mTOR signaling pathway_Homo sapiens_hsa041500.74447813
86Insulin signaling pathway_Homo sapiens_hsa049100.74195401
87Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.74010750
88Phototransduction_Homo sapiens_hsa047440.71717683
89Neurotrophin signaling pathway_Homo sapiens_hsa047220.71010686
90Cardiac muscle contraction_Homo sapiens_hsa042600.68101215
91AMPK signaling pathway_Homo sapiens_hsa041520.67115082
92Sulfur relay system_Homo sapiens_hsa041220.66972965
93Protein digestion and absorption_Homo sapiens_hsa049740.66887428
94Amphetamine addiction_Homo sapiens_hsa050310.66543177
95Estrogen signaling pathway_Homo sapiens_hsa049150.66521026
96Dilated cardiomyopathy_Homo sapiens_hsa054140.66023559
97Longevity regulating pathway - mammal_Homo sapiens_hsa042110.65753832
98Sulfur metabolism_Homo sapiens_hsa009200.65679317
99Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.64747873
100Cyanoamino acid metabolism_Homo sapiens_hsa004600.64562175
101Tight junction_Homo sapiens_hsa045300.63963610
102Renin secretion_Homo sapiens_hsa049240.63579418
103Thyroid hormone synthesis_Homo sapiens_hsa049180.63533711
104Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.63059451
105Glutamatergic synapse_Homo sapiens_hsa047240.61970051
106N-Glycan biosynthesis_Homo sapiens_hsa005100.61562379
107Mineral absorption_Homo sapiens_hsa049780.60504478
108Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.60230030
109Prion diseases_Homo sapiens_hsa050200.60070540
110Sphingolipid signaling pathway_Homo sapiens_hsa040710.59507921
111Glioma_Homo sapiens_hsa052140.59219018
112Cocaine addiction_Homo sapiens_hsa050300.59171754
113Cholinergic synapse_Homo sapiens_hsa047250.58873216
114Pancreatic secretion_Homo sapiens_hsa049720.58580399
115Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.58557066
116GnRH signaling pathway_Homo sapiens_hsa049120.58156481
117Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.57608582
118Central carbon metabolism in cancer_Homo sapiens_hsa052300.57178907
119Focal adhesion_Homo sapiens_hsa045100.56884159
120Oxytocin signaling pathway_Homo sapiens_hsa049210.56811262
121Dopaminergic synapse_Homo sapiens_hsa047280.56792748
122Dorso-ventral axis formation_Homo sapiens_hsa043200.56257162
123ErbB signaling pathway_Homo sapiens_hsa040120.56150863
124Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.55827057
125Histidine metabolism_Homo sapiens_hsa003400.55089250
126Basal cell carcinoma_Homo sapiens_hsa052170.53212174
127Chemical carcinogenesis_Homo sapiens_hsa052040.53163239
128cGMP-PKG signaling pathway_Homo sapiens_hsa040220.53151724
129Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.51852448
130PI3K-Akt signaling pathway_Homo sapiens_hsa041510.51503501
131Tyrosine metabolism_Homo sapiens_hsa003500.50001499
132Vitamin digestion and absorption_Homo sapiens_hsa049770.49833774
133Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.48865552
134Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.48799942
135alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.48707064
136Morphine addiction_Homo sapiens_hsa050320.47197183
137Gap junction_Homo sapiens_hsa045400.46570962
138Cysteine and methionine metabolism_Homo sapiens_hsa002700.46208170
139cAMP signaling pathway_Homo sapiens_hsa040240.45889867
140Phosphatidylinositol signaling system_Homo sapiens_hsa040700.44992841
141Thyroid hormone signaling pathway_Homo sapiens_hsa049190.44861804
142Staphylococcus aureus infection_Homo sapiens_hsa051500.44772038
143Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.44735644
144Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.43187885
145Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.42945580
146VEGF signaling pathway_Homo sapiens_hsa043700.42655101
147Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.39736577

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