PPP1R3B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes the catalytic subunit of the serine/theonine phosphatase, protein phosphatase-1. The encoded protein is expressed in liver and skeletal muscle tissue and may be involved in regulating glycogen synthesis in these tissues. This gene may be a involved in type 2 diabetes and maturity-onset diabetes of the young. Alternate splicing results in multiple transcript variants that encode the same protein. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.29361261
2L-phenylalanine catabolic process (GO:0006559)7.29361261
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.96491897
4L-phenylalanine metabolic process (GO:0006558)6.96491897
5aromatic amino acid family catabolic process (GO:0009074)6.62810967
6actin-myosin filament sliding (GO:0033275)6.35364654
7muscle filament sliding (GO:0030049)6.35364654
8triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.16217216
9tryptophan catabolic process (GO:0006569)6.04013834
10indole-containing compound catabolic process (GO:0042436)6.04013834
11indolalkylamine catabolic process (GO:0046218)6.04013834
12kynurenine metabolic process (GO:0070189)5.93557584
13bile acid biosynthetic process (GO:0006699)5.82034952
14alpha-linolenic acid metabolic process (GO:0036109)5.72043578
15tryptophan metabolic process (GO:0006568)5.70163801
16glyoxylate metabolic process (GO:0046487)5.59814889
17urea metabolic process (GO:0019627)5.59142201
18urea cycle (GO:0000050)5.59142201
19actin-mediated cell contraction (GO:0070252)5.38109826
20negative regulation of fibrinolysis (GO:0051918)5.37376296
21high-density lipoprotein particle remodeling (GO:0034375)5.32324853
22peptidyl-glutamic acid carboxylation (GO:0017187)5.31882757
23protein carboxylation (GO:0018214)5.31882757
24complement activation, alternative pathway (GO:0006957)5.27735298
25regulation of protein activation cascade (GO:2000257)5.19579119
26sulfur amino acid catabolic process (GO:0000098)5.18557633
27regulation of fibrinolysis (GO:0051917)5.16452732
28nitrogen cycle metabolic process (GO:0071941)5.13013457
29sarcoplasmic reticulum calcium ion transport (GO:0070296)5.12698582
30cysteine metabolic process (GO:0006534)5.03665364
31bile acid metabolic process (GO:0008206)5.00424731
32serine family amino acid catabolic process (GO:0009071)4.96716005
33fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.96610135
34regulation of triglyceride catabolic process (GO:0010896)4.87297725
35regulation of complement activation (GO:0030449)4.86673310
36aromatic amino acid family metabolic process (GO:0009072)4.81277516
37regulation of skeletal muscle contraction (GO:0014819)4.69341747
38homocysteine metabolic process (GO:0050667)4.68429628
39lysine catabolic process (GO:0006554)4.66887694
40lysine metabolic process (GO:0006553)4.66887694
41tyrosine metabolic process (GO:0006570)4.66310688
42amino-acid betaine metabolic process (GO:0006577)4.65462706
43regulation of cholesterol esterification (GO:0010872)4.65115825
44reverse cholesterol transport (GO:0043691)4.64218204
45protein-lipid complex remodeling (GO:0034368)4.62407777
46macromolecular complex remodeling (GO:0034367)4.62407777
47plasma lipoprotein particle remodeling (GO:0034369)4.62407777
48myofibril assembly (GO:0030239)4.58024859
49skeletal muscle contraction (GO:0003009)4.55553611
50alpha-amino acid catabolic process (GO:1901606)4.54877818
51triglyceride homeostasis (GO:0070328)4.54512528
52acylglycerol homeostasis (GO:0055090)4.54512528
53detection of molecule of bacterial origin (GO:0032490)4.53994876
54phospholipid efflux (GO:0033700)4.45210571
55plasma lipoprotein particle clearance (GO:0034381)4.38413973
56negative regulation of cholesterol transport (GO:0032375)4.38309075
57negative regulation of sterol transport (GO:0032372)4.38309075
58regulation of relaxation of muscle (GO:1901077)4.37066927
59bile acid and bile salt transport (GO:0015721)4.36392220
60actin filament-based movement (GO:0030048)4.36235201
61cellular ketone body metabolic process (GO:0046950)4.34262170
62coenzyme catabolic process (GO:0009109)4.27872675
63glycine metabolic process (GO:0006544)4.27257286
64indolalkylamine metabolic process (GO:0006586)4.26558661
65imidazole-containing compound metabolic process (GO:0052803)4.20000382
66cellular biogenic amine catabolic process (GO:0042402)4.19299398
67amine catabolic process (GO:0009310)4.19299398
68cellular glucuronidation (GO:0052695)4.18157030
69cellular amino acid catabolic process (GO:0009063)4.17889718
70ethanol oxidation (GO:0006069)4.14957971
71creatine metabolic process (GO:0006600)4.10571739
72positive regulation by symbiont of host defense response (GO:0052509)4.07150634
73modulation by symbiont of host defense response (GO:0052031)4.07150634
74modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.07150634
75modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.07150634
76positive regulation by organism of defense response of other organism involved in symbiotic interact4.07150634
77modulation by symbiont of host immune response (GO:0052553)4.07150634
78cholesterol efflux (GO:0033344)4.04248334
79sarcomere organization (GO:0045214)4.02248173
80benzene-containing compound metabolic process (GO:0042537)4.02025676
81glutamate metabolic process (GO:0006536)4.01523321
82plasma lipoprotein particle assembly (GO:0034377)4.01095867
83serine family amino acid metabolic process (GO:0009069)3.96651823
84low-density lipoprotein particle remodeling (GO:0034374)3.96270864
85negative regulation of cell killing (GO:0031342)3.93351832
86negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.93351832
87phospholipid homeostasis (GO:0055091)3.93211414
88dicarboxylic acid biosynthetic process (GO:0043650)3.89635473
89cellular modified amino acid catabolic process (GO:0042219)3.88874899
90arginine metabolic process (GO:0006525)3.88011579
91fibrinolysis (GO:0042730)3.87267737
92positive regulation of lipid catabolic process (GO:0050996)3.85755029
93acetyl-CoA metabolic process (GO:0006084)3.84218586
94very-low-density lipoprotein particle assembly (GO:0034379)3.82646911
95detection of external biotic stimulus (GO:0098581)3.80215810
96detection of other organism (GO:0098543)3.80109629
97antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.77696254
98negative regulation of lipase activity (GO:0060192)3.77062007
99organic acid catabolic process (GO:0016054)3.74723925
100carboxylic acid catabolic process (GO:0046395)3.74723925
101ketone body metabolic process (GO:1902224)3.74501339
102serine family amino acid biosynthetic process (GO:0009070)3.72632405
103aldehyde catabolic process (GO:0046185)3.72605723
104cholesterol homeostasis (GO:0042632)3.70266721
105drug catabolic process (GO:0042737)3.69968410
106short-chain fatty acid metabolic process (GO:0046459)3.69394202
107positive regulation of fatty acid beta-oxidation (GO:0032000)3.69208461
108glucuronate metabolic process (GO:0019585)3.68946180
109uronic acid metabolic process (GO:0006063)3.68946180
110response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.68697547
111positive regulation of lipoprotein lipase activity (GO:0051006)3.66749612
112positive regulation of triglyceride lipase activity (GO:0061365)3.66749612
113blood coagulation, intrinsic pathway (GO:0007597)3.66534680
114cytolysis (GO:0019835)3.66512532
115complement activation, classical pathway (GO:0006958)3.65505479
116plasma membrane repair (GO:0001778)3.65298904
117cofactor catabolic process (GO:0051187)3.65188059
118complement activation (GO:0006956)3.65155434
119sterol homeostasis (GO:0055092)3.64138323
120exogenous drug catabolic process (GO:0042738)3.63800470
121regulation of bile acid biosynthetic process (GO:0070857)3.61986764
122protein activation cascade (GO:0072376)3.61033815
123regulation of cholesterol homeostasis (GO:2000188)3.60417020
124positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.60336774
1252-oxoglutarate metabolic process (GO:0006103)3.59645195
126striated muscle contraction (GO:0006941)3.59556686
127fatty acid oxidation (GO:0019395)3.59183236
128plasma lipoprotein particle organization (GO:0071827)3.58862704
129leukocyte migration involved in inflammatory response (GO:0002523)3.58722401
130macrophage activation involved in immune response (GO:0002281)3.52935115
131skeletal muscle adaptation (GO:0043501)3.52569305
132cardiac myofibril assembly (GO:0055003)3.42426148
133detection of bacterium (GO:0016045)3.39412264
134response to mercury ion (GO:0046689)3.39392182
135detection of biotic stimulus (GO:0009595)3.32210545
136response to inactivity (GO:0014854)3.29095481
137production of molecular mediator involved in inflammatory response (GO:0002532)3.25233827
138cardiac muscle hypertrophy (GO:0003300)3.24868714
139response to muscle activity (GO:0014850)3.16842735
140actomyosin structure organization (GO:0031032)3.13625941
141glucan catabolic process (GO:0009251)3.12357694
142positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.09097345
143cellular polysaccharide catabolic process (GO:0044247)3.06840279
144striated muscle hypertrophy (GO:0014897)3.05737191
145negative regulation of protein activation cascade (GO:2000258)3.02552543
146regulation of interferon-beta biosynthetic process (GO:0045357)3.02100927
147regulation of necroptotic process (GO:0060544)3.01526246
148negative regulation of complement activation (GO:0045916)2.98338476
149regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.97705757
150epoxygenase P450 pathway (GO:0019373)2.97179927
151macrophage activation (GO:0042116)2.97166189
152cellular extravasation (GO:0045123)2.96720533
153positive regulation of gamma-delta T cell activation (GO:0046645)2.95472676
154glycogen catabolic process (GO:0005980)2.93593805
155growth hormone receptor signaling pathway (GO:0060396)2.91174615
156positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.90801939
157germinal center formation (GO:0002467)2.90795055
158regulation of gamma-delta T cell activation (GO:0046643)2.89980637
159striated muscle adaptation (GO:0014888)2.88455594
160cardiac muscle contraction (GO:0060048)2.86268787
161regulation of sequestering of triglyceride (GO:0010889)2.84675858
162muscle hypertrophy (GO:0014896)2.83903780
163muscle contraction (GO:0006936)2.81823273
164skeletal muscle tissue regeneration (GO:0043403)2.81679384
165microglial cell activation (GO:0001774)2.80777759
166negative regulation of lymphocyte mediated immunity (GO:0002707)2.80368176
167polysaccharide catabolic process (GO:0000272)2.76714132
168carnitine shuttle (GO:0006853)2.75740786
169omega-hydroxylase P450 pathway (GO:0097267)2.74572118
170antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.72495868
171striated muscle atrophy (GO:0014891)2.71798925
172response to peptidoglycan (GO:0032494)2.71472791
173neutrophil activation involved in immune response (GO:0002283)2.69511862
174response to host immune response (GO:0052572)2.67244425
175response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.67244425
176regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.62847522
177muscle system process (GO:0003012)2.62497328
178regulation of gamma-delta T cell differentiation (GO:0045586)2.60602957
179negative regulation of interleukin-12 production (GO:0032695)2.60516494
180antigen processing and presentation of endogenous antigen (GO:0019883)2.60199759
181skeletal muscle fiber development (GO:0048741)2.59029752
182fatty acid transmembrane transport (GO:1902001)2.56458139
183negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.55695664
184negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.54514932
185neutrophil mediated immunity (GO:0002446)2.51823269
186response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.50840062
187response to host (GO:0075136)2.50840062
188response to host defenses (GO:0052200)2.50840062
189negative regulation of humoral immune response (GO:0002921)2.50543151
190cardiac muscle adaptation (GO:0014887)2.49661113
191muscle hypertrophy in response to stress (GO:0003299)2.49661113

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse8.23967049
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse7.11012972
3EGR1_23403033_ChIP-Seq_LIVER_Mouse6.75303918
4* LXR_22158963_ChIP-Seq_LIVER_Mouse6.43050461
5BP1_19119308_ChIP-ChIP_Hs578T_Human6.34998907
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.36235115
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.21881693
8* CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.90608101
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse4.04465538
10CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.84732090
11FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.76874158
12SMAD_19615063_ChIP-ChIP_OVARY_Human2.37599553
13STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.35658021
14TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.33301460
15CDX2_19796622_ChIP-Seq_MESCs_Mouse2.23289847
16TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.02778320
17* ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.5986994
18HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.95047716
19RUNX_20019798_ChIP-Seq_JUKART_Human1.86216212
20RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.83346312
21CLOCK_20551151_ChIP-Seq_293T_Human1.81040080
22MYB_21317192_ChIP-Seq_ERMYB_Mouse1.76229867
23CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.74149669
24IRF8_21731497_ChIP-ChIP_J774_Mouse1.72665683
25STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.64582234
26GATA1_22025678_ChIP-Seq_K562_Human1.63947782
27MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.63042330
28FOXA2_19822575_ChIP-Seq_HepG2_Human1.57580846
29GATA2_21666600_ChIP-Seq_HMVEC_Human1.57104955
30* EP300_21415370_ChIP-Seq_HL-1_Mouse1.46691059
31* VDR_24787735_ChIP-Seq_THP-1_Human1.42135459
32SPI1_23127762_ChIP-Seq_K562_Human1.40481403
33HTT_18923047_ChIP-ChIP_STHdh_Human1.39322128
34* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.36992512
35HNF4A_19822575_ChIP-Seq_HepG2_Human1.36856790
36* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.32642809
37FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.30861717
38THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.29606200
39IRF8_22096565_ChIP-ChIP_GC-B_Human1.28564314
40IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.22013129
41LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.20175174
42LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.16646913
43KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.15260229
44KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.15260229
45KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.15260229
46TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.11529444
47RXRA_24833708_ChIP-Seq_LIVER_Mouse1.11249922
48SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.04107388
49PU_27001747_Chip-Seq_BMDM_Mouse1.04054907
50TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.03456599
51SMAD3_21741376_ChIP-Seq_HESCs_Human1.01854947
52TCF7_22412390_ChIP-Seq_EML_Mouse1.01430316
53RARG_19884340_ChIP-ChIP_MEFs_Mouse1.00881700
54PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.99022657
55SOX2_27498859_Chip-Seq_STOMACH_Mouse0.98137255
56Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.98055993
57ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.95064770
58* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94306903
59ESR1_15608294_ChIP-ChIP_MCF-7_Human0.94147710
60ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.93585651
61SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.93103451
62GATA1_19941827_ChIP-Seq_MEL86_Mouse0.92615798
63PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.91323558
64SPI1_23547873_ChIP-Seq_NB4_Human0.89426121
65* EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.89384862
66GATA4_25053715_ChIP-Seq_YYC3_Human0.89025007
67* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.88583917
68NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.86997368
69ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.86952866
70CJUN_26792858_Chip-Seq_BT549_Human0.85759155
71CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.85713103
72MYB_26560356_Chip-Seq_TH2_Human0.85707373
73IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.85240337
74SCL_19346495_ChIP-Seq_HPC-7_Human0.83388451
75RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.83387740
76SALL4_18804426_ChIP-ChIP_XEN_Mouse0.82850444
77GATA3_27048872_Chip-Seq_THYMUS_Human0.82420127
78CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.82361766
79ZNF217_24962896_ChIP-Seq_MCF-7_Human0.82297661
80GATA2_22383799_ChIP-Seq_G1ME_Mouse0.81872002
81* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.81816632
82VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.81591072
83EZH2_27294783_Chip-Seq_NPCs_Mouse0.81436120
84VDR_24763502_ChIP-Seq_THP-1_Human0.81175788
85ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.79946474
86AUTS2_25519132_ChIP-Seq_293T-REX_Human0.79423466
87CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.79171048
88BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.78330876
89ZNF263_19887448_ChIP-Seq_K562_Human0.78245493
90RUNX1_22412390_ChIP-Seq_EML_Mouse0.77861908
91STAT4_19710469_ChIP-ChIP_TH1__Mouse0.77801444
92SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.76837906
93SOX9_24532713_ChIP-Seq_HFSC_Mouse0.76699457
94KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.75671645
95SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.73429484
96KDM2B_26808549_Chip-Seq_SUP-B15_Human0.72737109
97PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.72372651
98ESR2_21235772_ChIP-Seq_MCF-7_Human0.71991852
99AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.69845151
100RARA_24833708_ChIP-Seq_LIVER_Mouse0.67971907
101KAP1_22055183_ChIP-Seq_ESCs_Mouse0.66560149
102NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.64508231
103NRF2_20460467_ChIP-Seq_MEFs_Mouse0.64508231
104EGR1_19032775_ChIP-ChIP_M12_Human0.61411049
105* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.61343849
106RARB_24833708_ChIP-Seq_LIVER_Mouse0.60885696
107CEBPB_22108803_ChIP-Seq_LS180_Human0.59936974
108ESR1_20079471_ChIP-ChIP_T-47D_Human0.58987669
109BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.58554709
110PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.58106832
111PPAR_26484153_Chip-Seq_NCI-H1993_Human0.57602436
112FOXA1_25552417_ChIP-Seq_VCAP_Human0.57305714
113GATA1_19941826_ChIP-Seq_K562_Human0.56672024
114FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.56508610
115STAT3_1855785_ChIP-Seq_MESCs_Mouse0.55856104
116ESR1_21235772_ChIP-Seq_MCF-7_Human0.55535755
117LXR_22292898_ChIP-Seq_THP-1_Human0.54901636
118RAD21_21589869_ChIP-Seq_MESCs_Mouse0.54788775
119NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.54253478
120FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.54225652
121GATA2_19941826_ChIP-Seq_K562_Human0.53904719
122FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.53683062
123PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.53554114
124FOXO3_23340844_ChIP-Seq_DLD1_Human0.52440392
125GATA1_19941827_ChIP-Seq_MEL_Mouse0.52211816
126SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.49642993
127* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.49364554
128* AR_20517297_ChIP-Seq_VCAP_Human0.49026916
129* BRD4_27068464_Chip-Seq_AML-cells_Mouse0.48836500
130CDX2_20551321_ChIP-Seq_CACO-2_Human0.48545305
131* STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.48526514
132TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.47241410
133GATA6_25053715_ChIP-Seq_YYC3_Human0.45788714
134ESET_19884257_ChIP-Seq_ESCs_Mouse0.45264590
135STAT1_17558387_ChIP-Seq_HELA_Human0.43980752
136GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.43401895
137IRF8_27001747_Chip-Seq_BMDM_Mouse0.43043118
138MYC_19915707_ChIP-ChIP_AK7_Human0.42629479
139P53_21459846_ChIP-Seq_SAOS-2_Human0.41588767
140CBP_21632823_ChIP-Seq_H3396_Human0.41352070
141* TBX20_22328084_ChIP-Seq_HEART_Mouse0.40917749
142* TBX20_22080862_ChIP-Seq_HEART_Mouse0.40917749
143GATA3_24758297_ChIP-Seq_MCF-7_Human0.39810524
144TAF2_19829295_ChIP-Seq_ESCs_Human0.39809804
145FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.39223466
146ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.38705649
147SOX2_20726797_ChIP-Seq_SW620_Human0.38337457
148E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.37228079
149BCAT_22108803_ChIP-Seq_LS180_Human0.36971151
150RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.36834997
151CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.36487563
152STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.36102710
153NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.36002211
154FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.35345070

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.97988138
2MP0005360_urolithiasis7.21802821
3MP0005085_abnormal_gallbladder_physiolo6.29131346
4MP0005365_abnormal_bile_salt6.11211467
5MP0008875_abnormal_xenobiotic_pharmacok4.95802489
6MP0003646_muscle_fatigue4.89366126
7MP0003806_abnormal_nucleotide_metabolis4.16235044
8MP0003252_abnormal_bile_duct3.87404334
9MP0010329_abnormal_lipoprotein_level3.57643629
10MP0004145_abnormal_muscle_electrophysio3.55791143
11MP0000749_muscle_degeneration3.42486425
12MP0009840_abnormal_foam_cell3.29042638
13MP0000751_myopathy3.23784884
14MP0004036_abnormal_muscle_relaxation3.14043967
15MP0005083_abnormal_biliary_tract3.08216985
16MP0004084_abnormal_cardiac_muscle2.82928420
17MP0005332_abnormal_amino_acid2.69532076
18MP0002332_abnormal_exercise_endurance2.66289062
19MP0003195_calcinosis2.61873357
20MP0001666_abnormal_nutrient_absorption2.51321473
21MP0002106_abnormal_muscle_physiology2.44508083
22MP0004087_abnormal_muscle_fiber2.31378333
23MP0003191_abnormal_cellular_cholesterol2.30244303
24MP0000609_abnormal_liver_physiology2.24688967
25MP0004510_myositis2.17839279
26MP0000750_abnormal_muscle_regeneration2.17224324
27MP0003828_pulmonary_edema2.14508498
28* MP0002118_abnormal_lipid_homeostasis2.11450136
29MP0000747_muscle_weakness2.10077991
30MP0004019_abnormal_vitamin_homeostasis2.09693784
31MP0004484_altered_response_of2.08266350
32MP0005620_abnormal_muscle_contractility2.07274725
33MP0003303_peritoneal_inflammation2.01980723
34MP0005369_muscle_phenotype2.01648294
35MP0002972_abnormal_cardiac_muscle1.95122831
36MP0002269_muscular_atrophy1.89418110
37MP0005319_abnormal_enzyme/_coenzyme1.88346045
38MP0002138_abnormal_hepatobiliary_system1.87135992
39MP0004233_abnormal_muscle_weight1.86582138
40MP0003868_abnormal_feces_composition1.84721597
41MP0000759_abnormal_skeletal_muscle1.83092866
42MP0001764_abnormal_homeostasis1.62845161
43MP0003221_abnormal_cardiomyocyte_apopto1.58428769
44MP0002127_abnormal_cardiovascular_syste1.58186000
45MP0009697_abnormal_copulation1.57895507
46MP0005584_abnormal_enzyme/coenzyme_acti1.57662588
47MP0010630_abnormal_cardiac_muscle1.56606314
48MP0005451_abnormal_body_composition1.54021384
49MP0002419_abnormal_innate_immunity1.50445561
50MP0008260_abnormal_autophagy1.46326848
51MP0005385_cardiovascular_system_phenoty1.37175343
52MP0001544_abnormal_cardiovascular_syste1.37175343
53MP0004215_abnormal_myocardial_fiber1.33771226
54MP0003300_gastrointestinal_ulcer1.29593962
55MP0003705_abnormal_hypodermis_morpholog1.29291475
56MP0006138_congestive_heart_failure1.28142633
57MP0003186_abnormal_redox_activity1.26848453
58MP0000598_abnormal_liver_morphology1.23925797
59MP0009643_abnormal_urine_homeostasis1.22261174
60MP0003950_abnormal_plasma_membrane1.21099751
61MP0002108_abnormal_muscle_morphology1.19918274
62MP0003011_delayed_dark_adaptation1.18813753
63MP0005025_abnormal_response_to1.15605903
64MP0003656_abnormal_erythrocyte_physiolo1.15574161
65MP0009764_decreased_sensitivity_to1.13904068
66MP0008004_abnormal_stomach_pH1.09927058
67MP0009763_increased_sensitivity_to1.09838652
68MP0002277_abnormal_respiratory_mucosa1.09713316
69MP0001533_abnormal_skeleton_physiology1.08972952
70MP0005670_abnormal_white_adipose1.08311883
71MP0005647_abnormal_sex_gland1.07383532
72MP0001835_abnormal_antigen_presentation1.06079243
73MP0010368_abnormal_lymphatic_system1.05803304
74MP0000733_abnormal_muscle_development1.02127854
75MP0000604_amyloidosis1.01623280
76MP0008469_abnormal_protein_level0.97910713
77MP0005387_immune_system_phenotype0.97031498
78MP0001790_abnormal_immune_system0.97031498
79MP0004130_abnormal_muscle_cell0.96951192
80MP0001800_abnormal_humoral_immune0.95896888
81MP0000685_abnormal_immune_system0.95244721
82MP0002254_reproductive_system_inflammat0.94884949
83MP0006036_abnormal_mitochondrial_physio0.89924421
84MP0008775_abnormal_heart_ventricle0.88262982
85MP0002971_abnormal_brown_adipose0.88073199
86* MP0009642_abnormal_blood_homeostasis0.87652538
87MP0003045_fibrosis0.87206691
88MP0002148_abnormal_hypersensitivity_rea0.86378714
89MP0002837_dystrophic_cardiac_calcinosis0.84856540
90MP0002723_abnormal_immune_serum0.84743286
91MP0003566_abnormal_cell_adhesion0.83822489
92MP0002998_abnormal_bone_remodeling0.82410477
93MP0005636_abnormal_mineral_homeostasis0.82034178
94MP0005334_abnormal_fat_pad0.79788816
95* MP0002078_abnormal_glucose_homeostasis0.79711333
96MP0005000_abnormal_immune_tolerance0.79412296
97MP0005376_homeostasis/metabolism_phenot0.78537546
98MP0002452_abnormal_antigen_presenting0.78358373
99MP0000465_gastrointestinal_hemorrhage0.77020696
100MP0005084_abnormal_gallbladder_morpholo0.76960574
101MP0005167_abnormal_blood-brain_barrier0.76770236
102MP0009765_abnormal_xenobiotic_induced0.76619593
103MP0005408_hypopigmentation0.75975241
104MP0005375_adipose_tissue_phenotype0.74893850
105MP0001851_eye_inflammation0.74796284
106MP0002420_abnormal_adaptive_immunity0.72908269
107MP0001819_abnormal_immune_cell0.72788285
108MP0005535_abnormal_body_temperature0.72089055
109MP0005220_abnormal_exocrine_pancreas0.72075023
110MP0000343_altered_response_to0.71899742
111MP0000013_abnormal_adipose_tissue0.70273799
112MP0003724_increased_susceptibility_to0.69543646
113MP0004947_skin_inflammation0.67355859
114MP0000266_abnormal_heart_morphology0.66751322
115MP0001661_extended_life_span0.65959111
116MP0003436_decreased_susceptibility_to0.65284170
117MP0002876_abnormal_thyroid_physiology0.65164241
118MP0005464_abnormal_platelet_physiology0.63914219
119MP0005666_abnormal_adipose_tissue0.62644215
120MP0009053_abnormal_anal_canal0.62314864
121MP0005266_abnormal_metabolism0.61485519
122MP0005448_abnormal_energy_balance0.61005235
123MP0003690_abnormal_glial_cell0.59772847
124MP0001756_abnormal_urination0.58079365
125MP0001853_heart_inflammation0.56695502
126MP0006035_abnormal_mitochondrial_morpho0.55647482
127MP0000639_abnormal_adrenal_gland0.53827372
128MP0002928_abnormal_bile_duct0.51209424
129MP0004782_abnormal_surfactant_physiolog0.48734509
130MP0003638_abnormal_response/metabolism_0.47391945
131MP0003329_amyloid_beta_deposits0.46976079
132MP0006082_CNS_inflammation0.46856913
133MP0009384_cardiac_valve_regurgitation0.46133129
134MP0002136_abnormal_kidney_physiology0.45628465
135MP0009115_abnormal_fat_cell0.44855650
136MP0008873_increased_physiological_sensi0.43924352
137MP0004381_abnormal_hair_follicle0.42237299
138MP0003075_altered_response_to0.41645073
139MP0005166_decreased_susceptibility_to0.41455120
140MP0005395_other_phenotype0.41119667
141MP0002970_abnormal_white_adipose0.41105843
142MP0009672_abnormal_birth_weight0.40741036
143MP0005248_abnormal_Harderian_gland0.40703841
144MP0000249_abnormal_blood_vessel0.40352764
145MP0003953_abnormal_hormone_level0.39958645
146MP0001845_abnormal_inflammatory_respons0.39484913
147MP0004883_abnormal_blood_vessel0.37836450
148MP0008874_decreased_physiological_sensi0.37360707
149MP0000230_abnormal_systemic_arterial0.35470199
150MP0001243_abnormal_dermal_layer0.35388240
151MP0001881_abnormal_mammary_gland0.34906911
152MP0005330_cardiomyopathy0.34621086
153MP0002060_abnormal_skin_morphology0.32893077
154MP0005164_abnormal_response_to0.32384341
155MP0003718_maternal_effect0.32333866
156MP0009785_altered_susceptibility_to0.32149665
157MP0005058_abnormal_lysosome_morphology0.31794304
158MP0005023_abnormal_wound_healing0.31561900
159MP0002168_other_aberrant_phenotype0.29866340
160MP0002796_impaired_skin_barrier0.28535831
161MP0002132_abnormal_respiratory_system0.28287207

Predicted human phenotypes

RankGene SetZ-score
1Muscle fiber inclusion bodies (HP:0100299)8.40460551
2Nemaline bodies (HP:0003798)8.29937818
3Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)8.13431139
4Deep venous thrombosis (HP:0002625)7.19407280
5Abnormality of aromatic amino acid family metabolism (HP:0004338)7.06420320
6Intrahepatic cholestasis (HP:0001406)7.00039463
7Abnormality of monocarboxylic acid metabolism (HP:0010996)6.43694827
8Prolonged partial thromboplastin time (HP:0003645)6.30281152
9Hypobetalipoproteinemia (HP:0003563)6.25032365
10Type 1 muscle fiber predominance (HP:0003803)6.23831010
11Xanthomatosis (HP:0000991)6.19408417
12Exercise-induced muscle cramps (HP:0003710)6.10388288
13Exercise-induced myalgia (HP:0003738)6.09653889
14Hyperlipoproteinemia (HP:0010980)5.47373219
15Muscle fiber splitting (HP:0003555)5.44908569
16Complement deficiency (HP:0004431)5.26924274
17Hyporeflexia of lower limbs (HP:0002600)4.89962387
18Muscle hypertrophy of the lower extremities (HP:0008968)4.78633433
19Hypolipoproteinemia (HP:0010981)4.73303019
20EMG: myopathic abnormalities (HP:0003458)4.72822259
21Joint hemorrhage (HP:0005261)4.69945394
22Hyperammonemia (HP:0001987)4.69118095
23Distal arthrogryposis (HP:0005684)4.62099983
24Hyperglycinemia (HP:0002154)4.47985540
25Epidermoid cyst (HP:0200040)4.47740362
26Calf muscle hypertrophy (HP:0008981)4.44299656
27Abnormality of the common coagulation pathway (HP:0010990)4.42106908
28Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.34924896
29Difficulty running (HP:0009046)4.34435475
30Hypoglycemic coma (HP:0001325)4.33165731
31Ketosis (HP:0001946)4.31778252
32Hypoalphalipoproteinemia (HP:0003233)4.18905256
33Abnormality of methionine metabolism (HP:0010901)4.11317938
34Hyperglycinuria (HP:0003108)4.10219411
35Abnormality of sulfur amino acid metabolism (HP:0004339)4.07540235
36Abnormality of glutamine family amino acid metabolism (HP:0010902)4.05360765
37Abnormality of glycine metabolism (HP:0010895)4.02993233
38Abnormality of serine family amino acid metabolism (HP:0010894)4.02993233
39Fat malabsorption (HP:0002630)3.96387120
40Abnormality of aspartate family amino acid metabolism (HP:0010899)3.95940268
41Myopathic facies (HP:0002058)3.92980740
42Rhabdomyolysis (HP:0003201)3.82580204
43Centrally nucleated skeletal muscle fibers (HP:0003687)3.82436708
44Abnormality of complement system (HP:0005339)3.82300828
45Abnormality of the left ventricular outflow tract (HP:0011103)3.73784632
46Subaortic stenosis (HP:0001682)3.73784632
47Abnormality of the calf musculature (HP:0001430)3.72097452
48Abnormality of pyrimidine metabolism (HP:0004353)3.69712750
49Abnormality of skeletal muscle fiber size (HP:0012084)3.67221012
50Abnormality of the intrinsic pathway (HP:0010989)3.65449632
51Abnormality of fatty-acid metabolism (HP:0004359)3.64931214
52Hypercholesterolemia (HP:0003124)3.59085179
53Neck muscle weakness (HP:0000467)3.57025088
54Increased connective tissue (HP:0009025)3.56616912
55Conjugated hyperbilirubinemia (HP:0002908)3.55940743
56Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.54256257
57Round ear (HP:0100830)3.53292128
58Rimmed vacuoles (HP:0003805)3.51344939
59Asymmetric septal hypertrophy (HP:0001670)3.46120810
60Ulnar deviation of the wrist (HP:0003049)3.42957165
61Orchitis (HP:0100796)3.37201483
62Myoglobinuria (HP:0002913)3.35596240
63Distal lower limb muscle weakness (HP:0009053)3.26622065
64Areflexia of lower limbs (HP:0002522)3.23667444
65Hyperbilirubinemia (HP:0002904)3.23631492
66Increased variability in muscle fiber diameter (HP:0003557)3.21390748
67Ketoacidosis (HP:0001993)3.18854616
68Sudden death (HP:0001699)3.16062897
69Retrobulbar optic neuritis (HP:0100654)3.15038125
70Optic neuritis (HP:0100653)3.15038125
71Abnormality of serum amino acid levels (HP:0003112)3.11146630
72Myositis (HP:0100614)3.05650992
73Myocardial infarction (HP:0001658)3.03145903
74Eczematoid dermatitis (HP:0000976)2.99867881
75Ventricular tachycardia (HP:0004756)2.99563794
76Abnormality of nucleobase metabolism (HP:0010932)2.95988584
77Steatorrhea (HP:0002570)2.95942311
78Hepatocellular carcinoma (HP:0001402)2.95447277
79Delayed CNS myelination (HP:0002188)2.93936482
80Muscle stiffness (HP:0003552)2.87841244
81Bundle branch block (HP:0011710)2.86270114
82Dicarboxylic aciduria (HP:0003215)2.86027070
83Abnormality of dicarboxylic acid metabolism (HP:0010995)2.86027070
84Skin nodule (HP:0200036)2.86015773
85Systemic lupus erythematosus (HP:0002725)2.81330583
86Metabolic acidosis (HP:0001942)2.76638701
87Spontaneous abortion (HP:0005268)2.75553769
88Hypochromic microcytic anemia (HP:0004840)2.75521071
89Frequent falls (HP:0002359)2.67330963
90Hypoglycemic seizures (HP:0002173)2.63290682
91Lethargy (HP:0001254)2.60009853
92Abnormality of purine metabolism (HP:0004352)2.59126501
93Gastrointestinal infarctions (HP:0005244)2.55601948
94Spontaneous hematomas (HP:0007420)2.53938699
95EMG: neuropathic changes (HP:0003445)2.52416744
96Recurrent gram-negative bacterial infections (HP:0005420)2.48671751
97Glomerulonephritis (HP:0000099)2.47268145
98Vascular calcification (HP:0004934)2.46144318
99Facial diplegia (HP:0001349)2.45468758
100Acanthocytosis (HP:0001927)2.45438574
101Cerebral edema (HP:0002181)2.38853191
102Spastic diplegia (HP:0001264)2.38613732
103Absent phalangeal crease (HP:0006109)2.36483683
104Abnormal gallbladder morphology (HP:0012437)2.35771155
105Mitral stenosis (HP:0001718)2.35589169
106Dilated cardiomyopathy (HP:0001644)2.34995496
107Generalized aminoaciduria (HP:0002909)2.32376263
108Esophageal varix (HP:0002040)2.32170711
109Recurrent abscess formation (HP:0002722)2.31637055
110Cholelithiasis (HP:0001081)2.30322853
111Keratoconjunctivitis sicca (HP:0001097)2.28649331
112Stomatitis (HP:0010280)2.28343564
113Lipoatrophy (HP:0100578)2.27855353
114Gout (HP:0001997)2.27743328
115Malignant hyperthermia (HP:0002047)2.27261479
116Irritability (HP:0000737)2.26982336
117Generalized muscle weakness (HP:0003324)2.23444198
118Gingival bleeding (HP:0000225)2.23214851
119Cardiovascular calcification (HP:0011915)2.19808778
120Pancreatitis (HP:0001733)2.18988399
121Neonatal onset (HP:0003623)2.18120049
122Cholecystitis (HP:0001082)2.17955276
123Abnormal gallbladder physiology (HP:0012438)2.17955276
124Renal cortical cysts (HP:0000803)2.17285517
125Late onset (HP:0003584)2.16733477
126Enlarged kidneys (HP:0000105)2.16647844
127Ventricular arrhythmia (HP:0004308)2.15741112
128Hyperinsulinemic hypoglycemia (HP:0000825)2.15234236
129Calcaneovalgus deformity (HP:0001848)2.15129106
130Menorrhagia (HP:0000132)2.14539488
131Peritonitis (HP:0002586)2.13245078
132Amyloidosis (HP:0011034)2.12509290
133Brushfield spots (HP:0001088)2.11362776
134Thrombophlebitis (HP:0004418)2.10734053
135Hyperkalemia (HP:0002153)2.10287147
136Bulbar palsy (HP:0001283)2.09801580
137Keratoconjunctivitis (HP:0001096)2.08973784
138Malnutrition (HP:0004395)2.08624044
139Recurrent bacterial skin infections (HP:0005406)2.08340986
140Vomiting (HP:0002013)2.07995775
141Sensorimotor neuropathy (HP:0007141)2.06598137
142Arterial thrombosis (HP:0004420)2.06060263
143Heart block (HP:0012722)2.03433267
144Chest pain (HP:0100749)2.03373685
145Abnormality of macrophages (HP:0004311)2.02120149
146Hemorrhage of the eye (HP:0011885)2.00713288
147Right ventricular cardiomyopathy (HP:0011663)2.00589720
148Hyperglycemia (HP:0003074)1.98075927
149Opisthotonus (HP:0002179)1.97999699
150Hydroxyprolinuria (HP:0003080)1.97051624
151Abnormality of proline metabolism (HP:0010907)1.97051624
152Abnormality of iron homeostasis (HP:0011031)1.96089512
153Abnormal cartilage morphology (HP:0002763)1.95806143
154Abnormality of the endocardium (HP:0004306)1.94214091
155Muscular dystrophy (HP:0003560)1.93926342
156Gowers sign (HP:0003391)1.91420751
157Scapular winging (HP:0003691)1.90896437
158Abnormal finger flexion creases (HP:0006143)1.90543367
159Hypochromic anemia (HP:0001931)1.90353327
160Abnormality of transition element cation homeostasis (HP:0011030)1.89990630
161Poikilocytosis (HP:0004447)1.88817920
162Abnormality of the gallbladder (HP:0005264)1.87869531
163Slender build (HP:0001533)1.87091357
164Neonatal hypoglycemia (HP:0001998)1.87018172
165Nausea (HP:0002018)1.84351156
166Toxemia of pregnancy (HP:0100603)1.84050298
167Hypertriglyceridemia (HP:0002155)1.83973036
168Elevated hepatic transaminases (HP:0002910)1.82962064
169Mildly elevated creatine phosphokinase (HP:0008180)1.82920016
170Myotonia (HP:0002486)1.82317763
171Proximal tubulopathy (HP:0000114)1.81541441
172Difficulty climbing stairs (HP:0003551)1.81021730
173Abnormal atrioventricular conduction (HP:0005150)1.79620722
174Hematochezia (HP:0002573)1.79545108
175Pulmonary embolism (HP:0002204)1.77976519
176Abnormal enzyme/coenzyme activity (HP:0012379)1.76151635
177Deformed tarsal bones (HP:0008119)1.76141880
178Hip contracture (HP:0003273)1.75819145
179Distal lower limb amyotrophy (HP:0008944)1.75583905
180Nephritis (HP:0000123)1.75108845
181Gingivitis (HP:0000230)1.74925071
182Rickets (HP:0002748)1.74228663
183Ventricular fibrillation (HP:0001663)1.67616379
184Hemoptysis (HP:0002105)1.65642313
185Anorexia (HP:0002039)1.63886536
186Palpitations (HP:0001962)1.63457578
187Atrioventricular block (HP:0001678)1.61473631

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.41152925
2SIK14.58667021
3ERN14.24858576
4TTN4.09957817
5FGFR44.05507203
6PKN23.07914100
7TAOK32.97554243
8PHKG12.79628546
9PHKG22.79628546
10INSRR2.75959143
11FLT32.43860996
12ERBB42.41130272
13TRIB32.30510480
14TYK21.78427670
15MAPK111.77380274
16MAP2K41.69274089
17PIK3CG1.69242830
18MST1R1.66050476
19NEK91.60848910
20LATS11.56784140
21DMPK1.55105599
22MAP2K31.50133759
23IRAK41.49897233
24KDR1.46834741
25PTK61.44899760
26FRK1.44208621
27NLK1.41687289
28JAK11.39343767
29KSR21.36565612
30RIPK41.31182763
31CAMK1D1.30257590
32PRKAA21.27448555
33JAK21.21858479
34TBK11.20265869
35ABL21.18068436
36MAP3K71.15009710
37FGFR21.13483365
38MAP3K101.12899412
39TGFBR21.12757306
40HCK1.10873939
41TRPM71.10075798
42MAP3K31.09651634
43IRAK31.09337772
44EPHA31.07918565
45TNK21.06380224
46RIPK11.03550110
47EPHB11.01629866
48FES1.01287327
49TIE11.00484001
50TAOK10.99162889
51MAP3K140.95686641
52FGR0.95196214
53STK240.94484631
54IRAK10.92052195
55DAPK20.90757107
56CDK60.90033553
57MAPK40.88380312
58PINK10.87949644
59CSK0.85018767
60CDK190.83837525
61MYLK0.80640539
62GRK60.80349949
63ERBB20.80298088
64MAPK120.78149297
65FGFR30.77819470
66YES10.77758541
67SGK30.77475130
68MAPK150.76674896
69STK38L0.76367598
70CSF1R0.75948593
71MARK20.75110024
72PTK2B0.74539807
73MARK30.71282941
74PRKAA10.70952501
75PIK3CA0.68937943
76PRKACG0.67791982
77MAP3K20.67786075
78ACVR1B0.66631591
79PRKCZ0.64818008
80GSK3A0.62265412
81DYRK1B0.62185521
82OBSCN0.61781010
83IKBKE0.61257142
84MAP2K60.59553497
85ZAP700.58542758
86CAMK2G0.57833605
87CDK40.57516570
88KSR10.56684125
89MAP4K10.56103207
90MAP3K110.56018577
91MET0.55961042
92PDK40.55753347
93PDK30.55753347
94MAPK70.55278292
95PRPF4B0.55013432
96MAP3K50.54925716
97SYK0.53297929
98MOS0.52951005
99IGF1R0.52220760
100CAMK1G0.52001930
101CDC42BPA0.51744983
102PTK20.50528588
103RAF10.49820032
104ITK0.49784350
105SGK20.48111776
106DYRK30.47217526
107FER0.47175636
108MUSK0.46794454
109KIT0.46445148
110STK110.46057923
111PRKCQ0.45591844
112LCK0.45584844
113PRKD20.45458459
114STK380.43108562
115PDPK10.42453990
116LYN0.42435183
117SGK4940.42233043
118SGK2230.42233043
119PRKD10.41375950
120RET0.40489649
121STK30.40419731
122WNK10.39867398
123MAP3K60.38469467
124TAOK20.37552521
125BMX0.37501421
126BTK0.37102509
127MATK0.37049050
128RPS6KC10.36788080
129RPS6KL10.36788080
130CAMK40.34981112
131MTOR0.34518211
132PDK10.31974182
133EGFR0.30535583
134CSNK1G10.29544253
135MAP2K10.28032162
136FGFR10.27268618
137PRKG20.26763560
138CHUK0.26661414
139JAK30.24750172
140MAP3K10.24299529
141ABL10.24284418
142TXK0.23295234
143PKN10.22677249
144BLK0.22424687
145MAP3K130.21611570

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.44420816
2Nitrogen metabolism_Homo sapiens_hsa009103.49719258
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.30154292
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.30082444
5Arginine biosynthesis_Homo sapiens_hsa002202.97878450
6Complement and coagulation cascades_Homo sapiens_hsa046102.71760996
7Tryptophan metabolism_Homo sapiens_hsa003802.67276913
8Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.67223154
9Fatty acid degradation_Homo sapiens_hsa000712.65767457
10Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.65385223
11Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.48847245
12Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.44721318
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.24971199
14Propanoate metabolism_Homo sapiens_hsa006402.11933385
15Butanoate metabolism_Homo sapiens_hsa006502.11178329
16Peroxisome_Homo sapiens_hsa041462.09980209
17Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.06629671
18PPAR signaling pathway_Homo sapiens_hsa033201.97220238
19Fatty acid metabolism_Homo sapiens_hsa012121.95694704
20Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.95367405
21Chemical carcinogenesis_Homo sapiens_hsa052041.89336847
22Staphylococcus aureus infection_Homo sapiens_hsa051501.87561636
23Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.87331646
24Histidine metabolism_Homo sapiens_hsa003401.85490867
25Steroid hormone biosynthesis_Homo sapiens_hsa001401.84398759
26Caffeine metabolism_Homo sapiens_hsa002321.80473294
27Drug metabolism - other enzymes_Homo sapiens_hsa009831.77131343
28beta-Alanine metabolism_Homo sapiens_hsa004101.75646985
29Dilated cardiomyopathy_Homo sapiens_hsa054141.69700270
30Retinol metabolism_Homo sapiens_hsa008301.69309188
312-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.68540580
32Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.65530284
33Osteoclast differentiation_Homo sapiens_hsa043801.63497103
34Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.61299376
35Selenocompound metabolism_Homo sapiens_hsa004501.55344173
36Phenylalanine metabolism_Homo sapiens_hsa003601.53153926
37Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.49254425
38Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.47807530
39Pyruvate metabolism_Homo sapiens_hsa006201.41675912
40Bile secretion_Homo sapiens_hsa049761.40778435
41Fatty acid elongation_Homo sapiens_hsa000621.40535676
42Tyrosine metabolism_Homo sapiens_hsa003501.38671102
43Starch and sucrose metabolism_Homo sapiens_hsa005001.36252321
44Leishmaniasis_Homo sapiens_hsa051401.35291110
45Malaria_Homo sapiens_hsa051441.30221610
46Sulfur metabolism_Homo sapiens_hsa009201.29244780
47Carbon metabolism_Homo sapiens_hsa012001.25904274
48Circadian rhythm_Homo sapiens_hsa047101.25384935
49Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.24944036
50Cysteine and methionine metabolism_Homo sapiens_hsa002701.22952802
51Biosynthesis of amino acids_Homo sapiens_hsa012301.21129012
52ABC transporters_Homo sapiens_hsa020101.18669604
53Fat digestion and absorption_Homo sapiens_hsa049751.17445823
54Folate biosynthesis_Homo sapiens_hsa007901.15370285
55Toll-like receptor signaling pathway_Homo sapiens_hsa046201.06288539
56Legionellosis_Homo sapiens_hsa051341.06052931
57Steroid biosynthesis_Homo sapiens_hsa001001.05571889
58NOD-like receptor signaling pathway_Homo sapiens_hsa046211.02042114
59Leukocyte transendothelial migration_Homo sapiens_hsa046701.00647458
60Maturity onset diabetes of the young_Homo sapiens_hsa049501.00110063
61Tuberculosis_Homo sapiens_hsa051520.99870290
62Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.95701916
63FoxO signaling pathway_Homo sapiens_hsa040680.94434179
64Platelet activation_Homo sapiens_hsa046110.91554659
65Arginine and proline metabolism_Homo sapiens_hsa003300.90591822
66Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.89743136
67Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.88791092
68Lysine degradation_Homo sapiens_hsa003100.88754301
69Sulfur relay system_Homo sapiens_hsa041220.88738304
70Jak-STAT signaling pathway_Homo sapiens_hsa046300.88418778
71Cyanoamino acid metabolism_Homo sapiens_hsa004600.86846973
72Acute myeloid leukemia_Homo sapiens_hsa052210.84733606
73Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.83593859
74Vitamin B6 metabolism_Homo sapiens_hsa007500.80917265
75Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.79699885
76Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.79537810
77Vitamin digestion and absorption_Homo sapiens_hsa049770.79373610
78Viral myocarditis_Homo sapiens_hsa054160.77846135
79Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.76742303
80B cell receptor signaling pathway_Homo sapiens_hsa046620.76600775
81Measles_Homo sapiens_hsa051620.76029781
82Glycerolipid metabolism_Homo sapiens_hsa005610.72970196
83Dorso-ventral axis formation_Homo sapiens_hsa043200.72313387
84Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.70472862
85One carbon pool by folate_Homo sapiens_hsa006700.70404364
86Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.68274951
87Chemokine signaling pathway_Homo sapiens_hsa040620.67508363
88Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.67061137
89TNF signaling pathway_Homo sapiens_hsa046680.66254856
90Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.65885615
91Fatty acid biosynthesis_Homo sapiens_hsa000610.64895113
92Renal cell carcinoma_Homo sapiens_hsa052110.63285907
93Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.62866869
94Glutathione metabolism_Homo sapiens_hsa004800.62279051
95Vascular smooth muscle contraction_Homo sapiens_hsa042700.61269759
96Pentose phosphate pathway_Homo sapiens_hsa000300.60649154
97NF-kappa B signaling pathway_Homo sapiens_hsa040640.59626515
98Influenza A_Homo sapiens_hsa051640.59432899
99Toxoplasmosis_Homo sapiens_hsa051450.58556527
100Focal adhesion_Homo sapiens_hsa045100.55740885
101cGMP-PKG signaling pathway_Homo sapiens_hsa040220.52815562
102T cell receptor signaling pathway_Homo sapiens_hsa046600.48822788
103Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.46101872
104Prolactin signaling pathway_Homo sapiens_hsa049170.45654293
105HIF-1 signaling pathway_Homo sapiens_hsa040660.45633767
106AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.44838587
107Metabolic pathways_Homo sapiens_hsa011000.44392192
108Adherens junction_Homo sapiens_hsa045200.44308476
109Oxytocin signaling pathway_Homo sapiens_hsa049210.43279597
110Galactose metabolism_Homo sapiens_hsa000520.35083521
111Adipocytokine signaling pathway_Homo sapiens_hsa049200.31588721
112Prion diseases_Homo sapiens_hsa050200.30620502
113* Insulin resistance_Homo sapiens_hsa049310.28418963
114Fructose and mannose metabolism_Homo sapiens_hsa000510.27636858
115alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.20698055
116Glucagon signaling pathway_Homo sapiens_hsa049220.17255612
117Glycerophospholipid metabolism_Homo sapiens_hsa005640.15483769
118Linoleic acid metabolism_Homo sapiens_hsa005910.14496018
119AMPK signaling pathway_Homo sapiens_hsa041520.08355801
120Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.07385850
121Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.01119286
122Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.2245330
123Pertussis_Homo sapiens_hsa05133-0.2106496
124Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.2082892
125Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.2015061
126Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.1996743
127RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622-0.1869569
128Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.1859673
129Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1834648
130Amoebiasis_Homo sapiens_hsa05146-0.1764776
131Renin-angiotensin system_Homo sapiens_hsa04614-0.1733748
132Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1629499
133Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.1518606
134Hepatitis C_Homo sapiens_hsa05160-0.1497021
135African trypanosomiasis_Homo sapiens_hsa05143-0.1449526
136Regulation of autophagy_Homo sapiens_hsa04140-0.1345662
137Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0955355
138Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.0912212
139Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.0801668
140* Insulin signaling pathway_Homo sapiens_hsa04910-0.0626180
141Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0308979

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