PPP1R3C

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a carbohydrate binding protein that is a subunit of the protein phosphatase 1 (PP1) complex. PP1 catalyzes reversible protein phosphorylation, which is important in a wide range of cellular activities. The encoded protein affects glycogen biosynthesis by activating glycogen synthase and limiting glycogen breakdown by reducing glycogen phosphorylase activity. DNA hypermethylation of this gene has been found in colorectal cancer patients. The encoded protein also interacts with the laforin protein, which is a protein tyrosine phosphatase implicated in Lafora disease. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of relaxation of muscle (GO:1901077)7.51976788
2response to muscle activity (GO:0014850)6.17095614
3response to inactivity (GO:0014854)5.51746768
4actomyosin structure organization (GO:0031032)5.36919378
5skeletal muscle fiber development (GO:0048741)5.34713897
6muscle contraction (GO:0006936)5.20568476
7regulation of cell communication by electrical coupling (GO:0010649)5.08497987
8muscle filament sliding (GO:0030049)4.95693540
9actin-myosin filament sliding (GO:0033275)4.95693540
10regulation of actin filament-based movement (GO:1903115)4.92764405
11myotube cell development (GO:0014904)4.92359865
12regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)4.89442841
13regulation of skeletal muscle contraction (GO:0014819)4.79344440
14cardiac muscle hypertrophy (GO:0003300)4.74537005
15carnitine shuttle (GO:0006853)4.70024867
16muscle system process (GO:0003012)4.66331702
17fatty acid transmembrane transport (GO:1902001)4.60635584
18striated muscle hypertrophy (GO:0014897)4.51741684
19lysine metabolic process (GO:0006553)4.39240592
20lysine catabolic process (GO:0006554)4.39240592
21triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.36883069
22L-phenylalanine catabolic process (GO:0006559)4.36093912
23erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.36093912
24alpha-linolenic acid metabolic process (GO:0036109)4.35634617
25muscle fiber development (GO:0048747)4.30451860
26skeletal muscle tissue development (GO:0007519)4.29410551
27NADH metabolic process (GO:0006734)4.27672014
28erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.20975146
29L-phenylalanine metabolic process (GO:0006558)4.20975146
302-oxoglutarate metabolic process (GO:0006103)4.17133549
31regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO4.16029500
32glycogen catabolic process (GO:0005980)4.15666039
33muscle cell cellular homeostasis (GO:0046716)4.11607122
34muscle tissue morphogenesis (GO:0060415)4.09441109
35negative regulation of potassium ion transmembrane transport (GO:1901380)4.09434906
36sarcoplasmic reticulum calcium ion transport (GO:0070296)4.09170194
37actin-mediated cell contraction (GO:0070252)4.08573691
38striated muscle adaptation (GO:0014888)4.00421194
39cardiac muscle tissue morphogenesis (GO:0055008)4.00295996
40muscle hypertrophy (GO:0014896)3.96620894
41regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.96544124
42fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.96098480
43regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.95561590
44glucan catabolic process (GO:0009251)3.92457397
45regulation of the force of heart contraction (GO:0002026)3.89265606
46regulation of striated muscle contraction (GO:0006942)3.88640282
47glyoxylate metabolic process (GO:0046487)3.85787872
48cardiac muscle cell development (GO:0055013)3.84607477
49positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.83595776
50aspartate family amino acid catabolic process (GO:0009068)3.83257940
51tricarboxylic acid cycle (GO:0006099)3.82733168
52sarcomere organization (GO:0045214)3.82268237
53kynurenine metabolic process (GO:0070189)3.81037733
54aromatic amino acid family catabolic process (GO:0009074)3.79410242
55adult heart development (GO:0007512)3.77665151
56positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.76380475
57muscle cell fate commitment (GO:0042693)3.75081052
58dicarboxylic acid biosynthetic process (GO:0043650)3.74406606
59cellular ketone body metabolic process (GO:0046950)3.70543671
60fatty acid beta-oxidation (GO:0006635)3.70049535
61bile acid biosynthetic process (GO:0006699)3.68477283
62* glycogen biosynthetic process (GO:0005978)3.68039391
63* glucan biosynthetic process (GO:0009250)3.68039391
64regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.66833951
65cellular polysaccharide catabolic process (GO:0044247)3.65474232
66positive regulation of fatty acid beta-oxidation (GO:0032000)3.63037412
67amino-acid betaine metabolic process (GO:0006577)3.61352999
68sulfur amino acid catabolic process (GO:0000098)3.60797720
69regulation of triglyceride catabolic process (GO:0010896)3.60477643
70carnitine transmembrane transport (GO:1902603)3.59497068
71cardiac cell development (GO:0055006)3.58996892
72muscle structure development (GO:0061061)3.58480702
73muscle organ development (GO:0007517)3.57512424
74striated muscle cell development (GO:0055002)3.56857660
75regulation of sequestering of triglyceride (GO:0010889)3.55299132
76regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.54825453
77acetyl-CoA metabolic process (GO:0006084)3.53576255
78valine metabolic process (GO:0006573)3.51257024
79positive regulation of fatty acid oxidation (GO:0046321)3.50099783
80skeletal muscle tissue regeneration (GO:0043403)3.49842857
81complement activation, alternative pathway (GO:0006957)3.48503879
82fructose metabolic process (GO:0006000)3.48188730
83myofibril assembly (GO:0030239)3.47244396
84polysaccharide catabolic process (GO:0000272)3.42559425
85fatty acid oxidation (GO:0019395)3.40407832
86lipid oxidation (GO:0034440)3.40234428
87regulation of calcium ion transmembrane transporter activity (GO:1901019)3.38409328
88regulation of calcium ion transmembrane transport (GO:1903169)3.38409328
89short-chain fatty acid metabolic process (GO:0046459)3.38098379
90cysteine metabolic process (GO:0006534)3.37450266
91indole-containing compound catabolic process (GO:0042436)3.37019956
92indolalkylamine catabolic process (GO:0046218)3.37019956
93tryptophan catabolic process (GO:0006569)3.37019956
94skeletal muscle contraction (GO:0003009)3.36362567
95carnitine transport (GO:0015879)3.35857341
96amino-acid betaine transport (GO:0015838)3.35857341
97fatty acid catabolic process (GO:0009062)3.35376985
98negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.35184884
99regulation of protein activation cascade (GO:2000257)3.34584663
100gluconeogenesis (GO:0006094)3.34174047
101branched-chain amino acid catabolic process (GO:0009083)3.33367651
102high-density lipoprotein particle remodeling (GO:0034375)3.33123934
103regulation of fatty acid oxidation (GO:0046320)3.31719863
104myoblast fusion (GO:0007520)3.31557648
105cardiac muscle hypertrophy in response to stress (GO:0014898)3.31512170
106muscle hypertrophy in response to stress (GO:0003299)3.31512170
107cardiac muscle adaptation (GO:0014887)3.31512170
108negative regulation of protein localization to cell surface (GO:2000009)3.31504530
109relaxation of muscle (GO:0090075)3.30607889
110regulation of myoblast differentiation (GO:0045661)3.30519390
111creatine metabolic process (GO:0006600)3.29423992
112alpha-amino acid catabolic process (GO:1901606)3.29122613
113homocysteine metabolic process (GO:0050667)3.27270125
114glutamate metabolic process (GO:0006536)3.27195044
115striated muscle contraction (GO:0006941)3.26867379
116succinate metabolic process (GO:0006105)3.26102012
117carnitine metabolic process (GO:0009437)3.25861039
118positive regulation of myotube differentiation (GO:0010831)3.25774605
119striated muscle atrophy (GO:0014891)3.25733246
120plasma lipoprotein particle remodeling (GO:0034369)3.23415038
121protein-lipid complex remodeling (GO:0034368)3.23415038
122macromolecular complex remodeling (GO:0034367)3.23415038
123serine family amino acid catabolic process (GO:0009071)3.22085117
124monocarboxylic acid catabolic process (GO:0072329)3.22053329
125cardiac muscle contraction (GO:0060048)3.21591564
126* glycogen metabolic process (GO:0005977)3.20774229
127regulation of acyl-CoA biosynthetic process (GO:0050812)3.20186028
128plasma membrane repair (GO:0001778)3.20131020
129cardiac myofibril assembly (GO:0055003)3.17203621
130negative regulation of fibrinolysis (GO:0051918)3.16789370
131ketone body metabolic process (GO:1902224)3.16275529
132response to activity (GO:0014823)3.15952323
133regulation of complement activation (GO:0030449)3.15532458
134striated muscle tissue development (GO:0014706)3.15282457
135cellular modified amino acid catabolic process (GO:0042219)3.15157256
136cellular amino acid catabolic process (GO:0009063)3.14256373
137muscle adaptation (GO:0043500)3.13655296
138heart contraction (GO:0060047)3.13572798
139heart process (GO:0003015)3.13572798
140regulation of skeletal muscle cell differentiation (GO:2001014)3.13343159
141* glucan metabolic process (GO:0044042)3.12949905
142* cellular glucan metabolic process (GO:0006073)3.12949905
143tryptophan metabolic process (GO:0006568)3.12767506
144response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.12620971
145muscle cell development (GO:0055001)3.12545362
146negative regulation of calcium ion transmembrane transporter activity (GO:1901020)3.12406811
147negative regulation of calcium ion transmembrane transport (GO:1903170)3.12406811
148urea cycle (GO:0000050)3.11847736
149urea metabolic process (GO:0019627)3.11847736
150skeletal muscle adaptation (GO:0043501)3.11712544
151reverse cholesterol transport (GO:0043691)3.10543237
152protein carboxylation (GO:0018214)3.09542562
153peptidyl-glutamic acid carboxylation (GO:0017187)3.09542562
154actin filament-based movement (GO:0030048)3.08824237
155fatty acid homeostasis (GO:0055089)3.08482655
156branched-chain amino acid metabolic process (GO:0009081)3.07882444
157regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.07853158
158regulation of muscle system process (GO:0090257)3.07169268
159coenzyme catabolic process (GO:0009109)3.07042202
160acylglycerol homeostasis (GO:0055090)3.06514076
161triglyceride homeostasis (GO:0070328)3.06514076
162ethanol oxidation (GO:0006069)3.06357157
163biotin metabolic process (GO:0006768)3.05349165
164regulation of fibrinolysis (GO:0051917)3.05067412
165positive regulation of myoblast differentiation (GO:0045663)2.98396031
166hexose biosynthetic process (GO:0019319)2.97786855
167myotube differentiation (GO:0014902)2.97159295
168positive regulation of cation channel activity (GO:2001259)2.95071888
169positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.91658564
170regulation of muscle contraction (GO:0006937)2.90862378
171muscle atrophy (GO:0014889)2.90078553
172muscle organ morphogenesis (GO:0048644)2.89575410

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse7.26596854
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse5.77684732
3RXR_22158963_ChIP-Seq_LIVER_Mouse4.97898313
4PPARA_22158963_ChIP-Seq_LIVER_Mouse4.36379589
5LXR_22158963_ChIP-Seq_LIVER_Mouse4.18441965
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.32398411
7NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.18531976
8EGR1_23403033_ChIP-Seq_LIVER_Mouse3.12291768
9TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.00655495
10RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.99868514
11TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.84878136
12ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.23936644
13ESR1_20079471_ChIP-ChIP_T-47D_Human2.04298009
14EP300_21415370_ChIP-Seq_HL-1_Mouse1.94599321
15CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.90621681
16TBX20_22080862_ChIP-Seq_HEART_Mouse1.67823427
17TBX20_22328084_ChIP-Seq_HEART_Mouse1.67823427
18* CLOCK_20551151_ChIP-Seq_293T_Human1.67616467
19RBPJ_22232070_ChIP-Seq_NCS_Mouse1.66573863
20THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.64442343
21PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.55888936
22RARG_19884340_ChIP-ChIP_MEFs_Mouse1.55407829
23CDX2_19796622_ChIP-Seq_MESCs_Mouse1.54832863
24NFIB_24661679_ChIP-Seq_LUNG_Mouse1.50052514
25BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.49259705
26TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.47547694
27FOXA2_19822575_ChIP-Seq_HepG2_Human1.47266117
28GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.46681746
29GATA4_21415370_ChIP-Seq_HL-1_Mouse1.44620729
30AR_21572438_ChIP-Seq_LNCaP_Human1.44539788
31NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.43226994
32ZNF263_19887448_ChIP-Seq_K562_Human1.39263743
33CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.37707272
34EZH2_22144423_ChIP-Seq_EOC_Human1.37379496
35ESR2_21235772_ChIP-Seq_MCF-7_Human1.30897649
36ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.29224924
37WT1_19549856_ChIP-ChIP_CCG9911_Human1.27522629
38DROSHA_22980978_ChIP-Seq_HELA_Human1.27439743
39SMAD_19615063_ChIP-ChIP_OVARY_Human1.25997308
40RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.24476201
41SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.24303625
42* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.21811267
43EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.21076163
44CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.19278465
45BCAT_22108803_ChIP-Seq_LS180_Human1.18663164
46CBX2_27304074_Chip-Seq_ESCs_Mouse1.17106340
47EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.16943555
48NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.15863833
49NRF2_20460467_ChIP-Seq_MEFs_Mouse1.15863833
50HTT_18923047_ChIP-ChIP_STHdh_Human1.14307633
51PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.13752681
52PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.12573932
53CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.12327113
54STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.10730714
55MTF2_20144788_ChIP-Seq_MESCs_Mouse1.08383404
56ISL1_27105846_Chip-Seq_CPCs_Mouse1.05462340
57SUZ12_27294783_Chip-Seq_NPCs_Mouse1.01548738
58EZH2_18974828_ChIP-Seq_MESCs_Mouse1.01547184
59RNF2_18974828_ChIP-Seq_MESCs_Mouse1.01547184
60AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.00562418
61* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.00552407
62SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.99785587
63TRIM28_21343339_ChIP-Seq_HEK293_Human0.99642264
64* SMC3_22415368_ChIP-Seq_MEFs_Mouse0.98867443
65EZH2_27294783_Chip-Seq_NPCs_Mouse0.98680807
66* TP53_20018659_ChIP-ChIP_R1E_Mouse0.98449732
67SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.97857246
68GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.96604167
69* SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.93754543
70SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.93696124
71CTNNB1_20460455_ChIP-Seq_HCT116_Human0.93646828
72WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.93422917
73CRX_20693478_ChIP-Seq_RETINA_Mouse0.93020675
74TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.90659538
75HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.90126681
76RNF2_27304074_Chip-Seq_ESCs_Mouse0.90048144
77SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.89954796
78PCGF2_27294783_Chip-Seq_ESCs_Mouse0.89663152
79AUTS2_25519132_ChIP-Seq_293T-REX_Human0.89330242
80SALL4_18804426_ChIP-ChIP_XEN_Mouse0.88095463
81STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.87881196
82EZH2_27294783_Chip-Seq_ESCs_Mouse0.87648419
83HNF4A_19822575_ChIP-Seq_HepG2_Human0.87055403
84FOXM1_26456572_ChIP-Seq_MCF-7_Human0.86678715
85YAP1_20516196_ChIP-Seq_MESCs_Mouse0.86244821
86PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.85958778
87SOX2_21211035_ChIP-Seq_LN229_Gbm0.84799551
88ERG_21242973_ChIP-ChIP_JURKAT_Human0.84369683
89MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.84268742
90SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.84190009
91CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.84162778
92EED_16625203_ChIP-ChIP_MESCs_Mouse0.83441179
93GATA1_22025678_ChIP-Seq_K562_Human0.83081790
94JARID2_20075857_ChIP-Seq_MESCs_Mouse0.82763382
95NR3C1_23031785_ChIP-Seq_PC12_Mouse0.82746873
96ESR1_15608294_ChIP-ChIP_MCF-7_Human0.82729177
97BP1_19119308_ChIP-ChIP_Hs578T_Human0.82636713
98* SOX9_24532713_ChIP-Seq_HFSC_Mouse0.82608622
99ZFP57_27257070_Chip-Seq_ESCs_Mouse0.82377460
100PIAS1_25552417_ChIP-Seq_VCAP_Human0.82364086
101DNAJC2_21179169_ChIP-ChIP_NT2_Human0.80351923
102CTCF_27219007_Chip-Seq_Bcells_Human0.79782908
103RXR_22108803_ChIP-Seq_LS180_Human0.77163619
104PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.76882233
105SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.76289502
106MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.76035850
107PPAR_26484153_Chip-Seq_NCI-H1993_Human0.73899983
108TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.73768416
109SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.73045804
110* SMAD4_21741376_ChIP-Seq_HESCs_Human0.72351101
111ZNF274_21170338_ChIP-Seq_K562_Hela0.71526760
112EZH2_27304074_Chip-Seq_ESCs_Mouse0.71214013
113* NR3C1_21868756_ChIP-Seq_MCF10A_Human0.71039568
114GBX2_23144817_ChIP-Seq_PC3_Human0.70926442
115HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.70709975
116NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.70461801
117* CBP_21632823_ChIP-Seq_H3396_Human0.69899898
118ZNF217_24962896_ChIP-Seq_MCF-7_Human0.68726346
119ESR1_21235772_ChIP-Seq_MCF-7_Human0.68569815
120PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.68455946
121MYC_27129775_Chip-Seq_CORNEA_Mouse0.68421637
122RARB_27405468_Chip-Seq_BRAIN_Mouse0.68267057
123SUZ12_27294783_Chip-Seq_ESCs_Mouse0.67583664
124AR_19668381_ChIP-Seq_PC3_Human0.67045879
125* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.66702861
126WT1_25993318_ChIP-Seq_PODOCYTE_Human0.66638903
127SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.65743944
128IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.65456160
129CBP_20019798_ChIP-Seq_JUKART_Human0.65456160
130JARID2_20064375_ChIP-Seq_MESCs_Mouse0.64347084
131SMAD4_21799915_ChIP-Seq_A2780_Human0.63459639
132AR_25329375_ChIP-Seq_VCAP_Human0.63110640
133ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.63055563
134CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.62787582
135CJUN_26792858_Chip-Seq_BT549_Human0.61998113
136SMAD3_21741376_ChIP-Seq_HESCs_Human0.61316766
137GATA1_19941826_ChIP-Seq_K562_Human0.60990293
138SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.60253105

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system4.62634494
2MP0003646_muscle_fatigue4.17154151
3MP0005360_urolithiasis4.12252352
4MP0002837_dystrophic_cardiac_calcinosis4.11661617
5MP0000751_myopathy3.71024887
6MP0005085_abnormal_gallbladder_physiolo3.59237521
7MP0000749_muscle_degeneration3.43229092
8MP0005365_abnormal_bile_salt3.35640439
9MP0004145_abnormal_muscle_electrophysio3.34791677
10MP0004036_abnormal_muscle_relaxation2.99855095
11MP0003806_abnormal_nucleotide_metabolis2.90122172
12* MP0004130_abnormal_muscle_cell2.81264811
13MP0004084_abnormal_cardiac_muscle2.49732128
14MP0008875_abnormal_xenobiotic_pharmacok2.44475701
15MP0004215_abnormal_myocardial_fiber2.42928781
16MP0004087_abnormal_muscle_fiber2.38663309
17MP0010329_abnormal_lipoprotein_level2.35923583
18MP0000747_muscle_weakness2.34278386
19MP0005330_cardiomyopathy2.33300876
20MP0005620_abnormal_muscle_contractility2.31606905
21MP0002269_muscular_atrophy2.25128414
22MP0003252_abnormal_bile_duct2.21041145
23MP0002106_abnormal_muscle_physiology2.19815432
24MP0009840_abnormal_foam_cell1.92440017
25MP0005670_abnormal_white_adipose1.87837100
26MP0000759_abnormal_skeletal_muscle1.87544971
27MP0005332_abnormal_amino_acid1.86061768
28MP0008438_abnormal_cutaneous_collagen1.85873285
29MP0005369_muscle_phenotype1.84382136
30MP0000750_abnormal_muscle_regeneration1.81952805
31MP0002972_abnormal_cardiac_muscle1.79113103
32MP0005083_abnormal_biliary_tract1.69567651
33MP0006036_abnormal_mitochondrial_physio1.67788696
34MP0005666_abnormal_adipose_tissue1.66753461
35MP0003705_abnormal_hypodermis_morpholog1.60500730
36MP0003195_calcinosis1.59908287
37MP0003137_abnormal_impulse_conducting1.59547846
38MP0002332_abnormal_exercise_endurance1.57329901
39* MP0002118_abnormal_lipid_homeostasis1.55575443
40MP0008775_abnormal_heart_ventricle1.51946932
41MP0005385_cardiovascular_system_phenoty1.48160462
42MP0001544_abnormal_cardiovascular_syste1.48160462
43MP0004233_abnormal_muscle_weight1.45413151
44MP0002971_abnormal_brown_adipose1.43875075
45MP0010630_abnormal_cardiac_muscle1.39192791
46MP0004185_abnormal_adipocyte_glucose1.35211895
47MP0006138_congestive_heart_failure1.30582007
48MP0005319_abnormal_enzyme/_coenzyme1.29095232
49MP0003191_abnormal_cellular_cholesterol1.28081131
50MP0004484_altered_response_of1.27791190
51MP0005275_abnormal_skin_tensile1.27194704
52MP0001666_abnormal_nutrient_absorption1.24366156
53MP0000609_abnormal_liver_physiology1.23676001
54* MP0005584_abnormal_enzyme/coenzyme_acti1.20177354
55MP0002108_abnormal_muscle_morphology1.16119820
56MP0003221_abnormal_cardiomyocyte_apopto1.13068344
57MP0005503_abnormal_tendon_morphology1.12357853
58MP0004085_abnormal_heartbeat1.07933624
59MP0005266_abnormal_metabolism1.05403252
60MP0006035_abnormal_mitochondrial_morpho1.05393555
61MP0009384_cardiac_valve_regurgitation1.05135662
62MP0005375_adipose_tissue_phenotype1.03843849
63MP0004272_abnormal_basement_membrane1.01819114
64MP0009780_abnormal_chondrocyte_physiolo0.99683574
65MP0001299_abnormal_eye_distance/0.98925747
66MP0002127_abnormal_cardiovascular_syste0.96885016
67MP0001958_emphysema0.96027640
68* MP0002078_abnormal_glucose_homeostasis0.94353914
69MP0003690_abnormal_glial_cell0.91979389
70MP0003950_abnormal_plasma_membrane0.90919648
71MP0005535_abnormal_body_temperature0.90808961
72MP0005334_abnormal_fat_pad0.89260664
73MP0000013_abnormal_adipose_tissue0.85778126
74MP0003941_abnormal_skin_development0.81384537
75MP0003279_aneurysm0.81035928
76MP0003868_abnormal_feces_composition0.80498507
77MP0010030_abnormal_orbit_morphology0.80399612
78MP0004043_abnormal_pH_regulation0.77954877
79MP0003329_amyloid_beta_deposits0.77947564
80MP0010368_abnormal_lymphatic_system0.77839068
81MP0000230_abnormal_systemic_arterial0.76698740
82MP0000762_abnormal_tongue_morphology0.75403336
83MP0004134_abnormal_chest_morphology0.74716617
84MP0005451_abnormal_body_composition0.74289883
85MP0003656_abnormal_erythrocyte_physiolo0.73910439
86MP0002822_catalepsy0.73542898
87MP0009250_abnormal_appendicular_skeleto0.72363329
88* MP0000266_abnormal_heart_morphology0.69415293
89MP0003045_fibrosis0.69254598
90MP0002896_abnormal_bone_mineralization0.67580888
91MP0004019_abnormal_vitamin_homeostasis0.65395606
92MP0002128_abnormal_blood_circulation0.64062835
93MP0009697_abnormal_copulation0.63919574
94MP0003879_abnormal_hair_cell0.63673454
95MP0009115_abnormal_fat_cell0.63670557
96MP0002909_abnormal_adrenal_gland0.63635194
97MP0005167_abnormal_blood-brain_barrier0.63164829
98MP0001764_abnormal_homeostasis0.61601498
99MP0005376_homeostasis/metabolism_phenot0.61525368
100MP0004270_analgesia0.61327436
101MP0000733_abnormal_muscle_development0.59755537
102MP0002254_reproductive_system_inflammat0.59151697
103MP0003011_delayed_dark_adaptation0.58263061
104MP0000604_amyloidosis0.58256809
105MP0005165_increased_susceptibility_to0.57752886
106MP0003828_pulmonary_edema0.57067747
107MP0005647_abnormal_sex_gland0.56591311
108MP0000003_abnormal_adipose_tissue0.55933991
109MP0001661_extended_life_span0.55444869
110MP0000534_abnormal_ureter_morphology0.55190168
111MP0005595_abnormal_vascular_smooth0.54929132
112MP0005448_abnormal_energy_balance0.54426370
113MP0009643_abnormal_urine_homeostasis0.51725938
114MP0003075_altered_response_to0.51602085
115MP0000343_altered_response_to0.51012076
116MP0004510_myositis0.50078450
117MP0003186_abnormal_redox_activity0.49718925
118MP0000579_abnormal_nail_morphology0.49082621
119MP0000767_abnormal_smooth_muscle0.42764869
120MP0002114_abnormal_axial_skeleton0.42053393
121MP0001542_abnormal_bone_strength0.41311216
122MP0005187_abnormal_penis_morphology0.39545873
123MP0004858_abnormal_nervous_system0.38313270
124MP0008569_lethality_at_weaning0.38295821
125MP0004142_abnormal_muscle_tone0.36425695
126MP0002249_abnormal_larynx_morphology0.31595572
127MP0009672_abnormal_birth_weight0.31399874
128MP0001879_abnormal_lymphatic_vessel0.31054667
129MP0005623_abnormal_meninges_morphology0.30734104
130MP0003385_abnormal_body_wall0.28668350
131MP0003948_abnormal_gas_homeostasis0.28318327
132MP0002734_abnormal_mechanical_nocicepti0.26259495
133MP0005452_abnormal_adipose_tissue0.26057588
134MP0002638_abnormal_pupillary_reflex0.24964094
135MP0003942_abnormal_urinary_system0.23419797
136MP0001943_abnormal_respiration0.23105513

Predicted human phenotypes

RankGene SetZ-score
1Exercise-induced myalgia (HP:0003738)6.68576819
2Exercise-induced muscle cramps (HP:0003710)6.11034781
3Muscle fiber inclusion bodies (HP:0100299)5.33406267
4Myoglobinuria (HP:0002913)5.24073054
5Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)5.07947068
6Muscle hypertrophy of the lower extremities (HP:0008968)4.59191436
7Type 1 muscle fiber predominance (HP:0003803)4.57734997
8Nemaline bodies (HP:0003798)4.50624328
9Calf muscle hypertrophy (HP:0008981)4.45496235
10Centrally nucleated skeletal muscle fibers (HP:0003687)4.33342717
11Hyporeflexia of lower limbs (HP:0002600)4.10676851
12Sudden death (HP:0001699)4.05132793
13Muscle fiber splitting (HP:0003555)3.96728415
14Rhabdomyolysis (HP:0003201)3.91902090
15Hypoalphalipoproteinemia (HP:0003233)3.81872257
16Distal lower limb muscle weakness (HP:0009053)3.74062222
17Intrahepatic cholestasis (HP:0001406)3.70396486
18Difficulty running (HP:0009046)3.64293801
19Deep venous thrombosis (HP:0002625)3.63442879
20Xanthomatosis (HP:0000991)3.57861889
21Hypoglycemic coma (HP:0001325)3.56272201
22Muscle stiffness (HP:0003552)3.53535809
23Ketosis (HP:0001946)3.46783534
24Distal arthrogryposis (HP:0005684)3.44624089
25Abnormality of the calf musculature (HP:0001430)3.43871610
26Hyperlipoproteinemia (HP:0010980)3.43335819
27Ketoacidosis (HP:0001993)3.42805411
28EMG: myopathic abnormalities (HP:0003458)3.42504945
29Hypolipoproteinemia (HP:0010981)3.34586513
30Hyperammonemia (HP:0001987)3.29772270
31Round ear (HP:0100830)3.25198916
32Hyperglycinuria (HP:0003108)3.14284552
33Increased connective tissue (HP:0009025)3.12051531
34Mildly elevated creatine phosphokinase (HP:0008180)3.10297741
35Abnormality of aromatic amino acid family metabolism (HP:0004338)3.07775526
36Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.03118273
37Asymmetric septal hypertrophy (HP:0001670)3.01809454
38Hypobetalipoproteinemia (HP:0003563)3.00378657
39Subaortic stenosis (HP:0001682)2.98539559
40Abnormality of the left ventricular outflow tract (HP:0011103)2.98539559
41Myopathic facies (HP:0002058)2.98485258
42Abnormality of serine family amino acid metabolism (HP:0010894)2.98091674
43Abnormality of glycine metabolism (HP:0010895)2.98091674
44Ventricular tachycardia (HP:0004756)2.97336319
45EMG: neuropathic changes (HP:0003445)2.94292063
46Myotonia (HP:0002486)2.94175123
47Hyperglycinemia (HP:0002154)2.90539968
48Complement deficiency (HP:0004431)2.85924419
49Slender build (HP:0001533)2.84436192
50Malignant hyperthermia (HP:0002047)2.82984942
51Generalized muscle weakness (HP:0003324)2.74126941
52Abnormality of fatty-acid metabolism (HP:0004359)2.70336758
53Prolonged partial thromboplastin time (HP:0003645)2.69604654
54Spinal rigidity (HP:0003306)2.67001419
55Abnormality of monocarboxylic acid metabolism (HP:0010996)2.66587979
56Ulnar deviation of the wrist (HP:0003049)2.65175261
57Epidermoid cyst (HP:0200040)2.62051057
58Increased variability in muscle fiber diameter (HP:0003557)2.58730691
59Right ventricular cardiomyopathy (HP:0011663)2.58252393
60Lipoatrophy (HP:0100578)2.57816316
61Abnormality of skeletal muscle fiber size (HP:0012084)2.56564709
62Distal lower limb amyotrophy (HP:0008944)2.51631210
63Scapular winging (HP:0003691)2.48726183
64Atrial fibrillation (HP:0005110)2.43311111
65Gowers sign (HP:0003391)2.43131043
66Absent phalangeal crease (HP:0006109)2.42238958
67Abnormality of dicarboxylic acid metabolism (HP:0010995)2.41242623
68Dicarboxylic aciduria (HP:0003215)2.41242623
69Fetal akinesia sequence (HP:0001989)2.38682893
70Hip contracture (HP:0003273)2.38655670
71Cholelithiasis (HP:0001081)2.34868557
72Bulbar palsy (HP:0001283)2.34584998
73Atrioventricular block (HP:0001678)2.33351953
74Hyperinsulinemic hypoglycemia (HP:0000825)2.32683163
75Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.31501889
76Heart block (HP:0012722)2.30904584
77Abnormality of the calcaneus (HP:0008364)2.30540002
78Limb-girdle muscle atrophy (HP:0003797)2.30358431
79Dilated cardiomyopathy (HP:0001644)2.29952482
80Palpitations (HP:0001962)2.25167551
81Primary atrial arrhythmia (HP:0001692)2.23877735
82Abnormal gallbladder morphology (HP:0012437)2.22700121
83Bundle branch block (HP:0011710)2.19364322
84Ventricular arrhythmia (HP:0004308)2.18914694
85Cerebral edema (HP:0002181)2.18442404
86Skin nodule (HP:0200036)2.18281447
87Metabolic acidosis (HP:0001942)2.16545563
88Abnormal finger flexion creases (HP:0006143)2.16093011
89Syncope (HP:0001279)2.16055460
90Hyperglycemia (HP:0003074)2.15632181
91Muscular dystrophy (HP:0003560)2.14752211
92Abnormal atrioventricular conduction (HP:0005150)2.12859198
93Neck muscle weakness (HP:0000467)2.11982415
94Gout (HP:0001997)2.11529081
95Supraventricular tachycardia (HP:0004755)2.10977954
96Rimmed vacuoles (HP:0003805)2.10605799
97Abnormality of the neuromuscular junction (HP:0003398)2.09948701
98Fatigable weakness (HP:0003473)2.09948701
99Weak cry (HP:0001612)2.09368674
100Calcaneovalgus deformity (HP:0001848)2.07482392
101Hyperkalemia (HP:0002153)2.07229378
102Supraventricular arrhythmia (HP:0005115)2.06243641
103Abnormality of serum amino acid levels (HP:0003112)2.05386994
104Proximal amyotrophy (HP:0007126)2.04629642
105Abnormality of the foot musculature (HP:0001436)2.04342628
106Abnormality of the shoulder girdle musculature (HP:0001435)1.99857173
107Abnormality of aspartate family amino acid metabolism (HP:0010899)1.98791113
108Waddling gait (HP:0002515)1.98331286
109Lower limb amyotrophy (HP:0007210)1.97234994
110Areflexia of lower limbs (HP:0002522)1.96449792
111Hypoglycemic seizures (HP:0002173)1.94900978
112Abnormality of the common coagulation pathway (HP:0010990)1.94745051
113Difficulty climbing stairs (HP:0003551)1.94606544
114Progressive muscle weakness (HP:0003323)1.94003861
115Abnormality of sulfur amino acid metabolism (HP:0004339)1.93598033
116Hypercholesterolemia (HP:0003124)1.92326866
117Deformed tarsal bones (HP:0008119)1.92081170
118Increased purine levels (HP:0004368)1.92080148
119Hyperuricemia (HP:0002149)1.92080148
120Abnormality of methionine metabolism (HP:0010901)1.91679662
121Foot dorsiflexor weakness (HP:0009027)1.90451718
122Prolonged QT interval (HP:0001657)1.89582870
123Abnormality of glutamine family amino acid metabolism (HP:0010902)1.89085304
124Limited hip movement (HP:0008800)1.89008265
125Lethargy (HP:0001254)1.88331356
126Abnormality of the Achilles tendon (HP:0005109)1.88255224
127Abnormality of purine metabolism (HP:0004352)1.87218502
128Frequent falls (HP:0002359)1.86820761
129Limb-girdle muscle weakness (HP:0003325)1.86643413
130Late onset (HP:0003584)1.86499431
131Metatarsus adductus (HP:0001840)1.83814230
132Respiratory insufficiency due to muscle weakness (HP:0002747)1.81359376
133Popliteal pterygium (HP:0009756)1.75282690
134Abnormality of the musculature of the pelvis (HP:0001469)1.69430109
135Abnormality of the hip-girdle musculature (HP:0001445)1.69430109
136Ulnar deviation of finger (HP:0009465)1.66868170
137Facial diplegia (HP:0001349)1.60736625
138Protrusio acetabuli (HP:0003179)1.56201082
139Long clavicles (HP:0000890)1.55542647
140Ragged-red muscle fibers (HP:0003200)1.55251947
141Shoulder girdle muscle weakness (HP:0003547)1.52622639
142Steppage gait (HP:0003376)1.51312617
143Pelvic girdle muscle weakness (HP:0003749)1.49564751
144Aortic aneurysm (HP:0004942)1.48950082
145Exercise intolerance (HP:0003546)1.48599299
146Breech presentation (HP:0001623)1.46223150
147Nonprogressive disorder (HP:0003680)1.42997406
148Oligomenorrhea (HP:0000876)1.41488003
149Generalized amyotrophy (HP:0003700)1.38151707
150Ulnar deviation of the hand or of fingers of the hand (HP:0001193)1.38062923
151Achilles tendon contracture (HP:0001771)1.37391142

Predicted kinase interactions (KEA)

RankGene SetZ-score
1OBSCN5.79639045
2PHKG24.57846882
3PHKG14.57846882
4TTN3.98580802
5BCKDK3.61443188
6TRIB33.14818694
7SIK12.41183859
8PDK32.40083492
9PDK42.40083492
10PKN22.37077695
11PINK12.17437884
12NEK12.00569543
13PIK3CG2.00494657
14LMTK21.97686167
15MAP3K71.88118792
16MUSK1.80902470
17INSRR1.79577423
18MAP2K41.76682070
19PIK3CA1.76628864
20DMPK1.69969451
21MAPK121.52164700
22NME11.49932907
23LIMK11.38463551
24PDK21.36298805
25TRPM71.32368423
26MAP2K31.27201047
27EPHA41.26881872
28LATS11.22310418
29PRKAA21.20601080
30ERN11.18175202
31MARK11.14584370
32FGFR41.14124392
33RIPK11.10419313
34MYLK1.06518753
35MOS1.03520439
36MAPK111.00142495
37NEK90.98728352
38EEF2K0.96544184
39STK240.93764188
40TIE10.93698106
41* PRKAA10.85642393
42CAMK2G0.81056110
43PAK30.80096775
44FLT30.80021969
45ERBB30.78284401
46DYRK1B0.76002346
47STK380.73389078
48PTK60.70436431
49SGK30.70144512
50STK38L0.68820014
51CAMK1D0.67784512
52ERBB40.66874004
53CCNB10.66495632
54ROCK10.64324488
55MAP3K40.62555059
56CAMK2D0.62117958
57MAP2K60.61327081
58CAMK1G0.60718196
59SGK20.60444394
60PRKD10.60186545
61MAP3K50.59144300
62MAP3K30.58088207
63PRKD30.57656401
64PDGFRA0.56040159
65TAOK20.55765230
66FGFR20.55725831
67DAPK20.54778385
68AKT30.54263458
69PRKACG0.53440074
70PAK60.52808179
71CAMK2B0.52727863
72LATS20.52132495
73PDPK10.51966971
74FGFR30.51538603
75PKN10.50856035
76RET0.50240833
77KSR20.49728311
78ILK0.49038866
79MAPK70.48617344
80DDR20.48457554
81ICK0.46971437
82AKT20.46865629
83PDK10.43106679
84CAMK2A0.43040575
85SGK4940.41981531
86SGK2230.41981531
87CAMK40.41009634
88JAK20.39692753
89EPHB10.39269105
90PRKACB0.39195491
91SGK10.38979122
92JAK10.38746484
93CAMKK10.38740640
94ZAK0.38679748
95RPS6KA30.38523889
96NTRK20.38399557
97FGFR10.38150843
98PRKACA0.37716720
99MAPK40.36593638
100PRKCH0.36422642
101MAP2K10.35722402
102FER0.35631690
103MET0.34721575
104PRKG10.34274521
105MAPKAPK30.34242511
106MAP3K130.34029299
107TGFBR20.32376983
108CDC42BPA0.30550105
109MST1R0.29811654
110CAMK10.29179885
111MAP3K60.28755584
112PRKCG0.27380666
113NTRK30.26917072
114MTOR0.26525385
115DAPK30.25860657
116PTK2B0.25794096
117RPS6KB10.24956093
118MAPK100.24060003
119ARAF0.23461525
120ROCK20.23457092
121PAK20.21144751
122GRK70.20937429
123PTK20.20885215
124RAF10.19865592
125RPS6KL10.18633875
126RPS6KC10.18633875
127RPS6KB20.16554472
128EPHA30.16176387
129RPS6KA10.16026814
130MARK20.16023442
131WNK10.13772020
132MAP3K10.13207297
133MAP3K90.12508671
134RPS6KA60.12503134
135NTRK10.12325682
136RPS6KA20.12072267

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009104.17884169
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.28548177
3Primary bile acid biosynthesis_Homo sapiens_hsa001203.13951360
4Fatty acid degradation_Homo sapiens_hsa000713.04036191
5Propanoate metabolism_Homo sapiens_hsa006402.90885598
62-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.88635564
7Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.84124669
8Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.73831544
9Arginine biosynthesis_Homo sapiens_hsa002202.64486439
10Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.52332344
11Fatty acid metabolism_Homo sapiens_hsa012122.43875135
12PPAR signaling pathway_Homo sapiens_hsa033202.09499086
13Butanoate metabolism_Homo sapiens_hsa006502.07179565
14Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.05450825
15Tryptophan metabolism_Homo sapiens_hsa003802.01107495
16Carbon metabolism_Homo sapiens_hsa012001.89361549
17Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.84477016
18Complement and coagulation cascades_Homo sapiens_hsa046101.72603157
19Peroxisome_Homo sapiens_hsa041461.70884694
20Starch and sucrose metabolism_Homo sapiens_hsa005001.69658678
21Pyruvate metabolism_Homo sapiens_hsa006201.67945429
22Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.67045944
23Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.66403348
24Fatty acid biosynthesis_Homo sapiens_hsa000611.52805036
25beta-Alanine metabolism_Homo sapiens_hsa004101.48431939
26Biosynthesis of amino acids_Homo sapiens_hsa012301.46255423
27Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.44270358
28Cardiac muscle contraction_Homo sapiens_hsa042601.38005505
29Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.38004157
30Bile secretion_Homo sapiens_hsa049761.35877950
31Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.31040228
32Fatty acid elongation_Homo sapiens_hsa000621.29920329
33Dilated cardiomyopathy_Homo sapiens_hsa054141.27490941
34Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.24297038
35Pentose and glucuronate interconversions_Homo sapiens_hsa000401.17646184
36Caffeine metabolism_Homo sapiens_hsa002321.14968030
37Phenylalanine metabolism_Homo sapiens_hsa003601.13593146
38Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.11751271
39Focal adhesion_Homo sapiens_hsa045101.10150306
40Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.09828513
41Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.05015143
42Tyrosine metabolism_Homo sapiens_hsa003501.01133378
43Arginine and proline metabolism_Homo sapiens_hsa003301.00378693
44Chemical carcinogenesis_Homo sapiens_hsa052040.98741253
45Sulfur metabolism_Homo sapiens_hsa009200.97901714
46ECM-receptor interaction_Homo sapiens_hsa045120.97721594
47Glucagon signaling pathway_Homo sapiens_hsa049220.95266072
48Tight junction_Homo sapiens_hsa045300.95082183
49Adipocytokine signaling pathway_Homo sapiens_hsa049200.92519699
50Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.91905533
51Cysteine and methionine metabolism_Homo sapiens_hsa002700.90623439
52Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.87576378
53Steroid hormone biosynthesis_Homo sapiens_hsa001400.86599254
54* Insulin resistance_Homo sapiens_hsa049310.86231057
55Histidine metabolism_Homo sapiens_hsa003400.85494829
56ABC transporters_Homo sapiens_hsa020100.84218838
57Retinol metabolism_Homo sapiens_hsa008300.82693871
58Fat digestion and absorption_Homo sapiens_hsa049750.82245222
59Staphylococcus aureus infection_Homo sapiens_hsa051500.78616479
60Glycerolipid metabolism_Homo sapiens_hsa005610.73853439
61Lysine degradation_Homo sapiens_hsa003100.69755970
62Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.66631613
63Galactose metabolism_Homo sapiens_hsa000520.66130757
64GnRH signaling pathway_Homo sapiens_hsa049120.63459125
65* Insulin signaling pathway_Homo sapiens_hsa049100.62924520
66Circadian rhythm_Homo sapiens_hsa047100.62667513
67Selenocompound metabolism_Homo sapiens_hsa004500.62609845
68Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.62457174
69Drug metabolism - other enzymes_Homo sapiens_hsa009830.62265631
70Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.61562213
71AMPK signaling pathway_Homo sapiens_hsa041520.61451480
72Long-term potentiation_Homo sapiens_hsa047200.61133873
73Fructose and mannose metabolism_Homo sapiens_hsa000510.60175759
74Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.59136474
75Thyroid hormone signaling pathway_Homo sapiens_hsa049190.57525846
76Pentose phosphate pathway_Homo sapiens_hsa000300.57151564
77Parkinsons disease_Homo sapiens_hsa050120.54612154
78Amoebiasis_Homo sapiens_hsa051460.48981347
79Adherens junction_Homo sapiens_hsa045200.48274109
80FoxO signaling pathway_Homo sapiens_hsa040680.47845533
81Alzheimers disease_Homo sapiens_hsa050100.46618974
82Protein digestion and absorption_Homo sapiens_hsa049740.45569423
83Oxidative phosphorylation_Homo sapiens_hsa001900.43343407
84Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.42733042
85Regulation of actin cytoskeleton_Homo sapiens_hsa048100.42232766
86Calcium signaling pathway_Homo sapiens_hsa040200.41126087
87Sulfur relay system_Homo sapiens_hsa041220.39990206
88Salivary secretion_Homo sapiens_hsa049700.39567386
89Vitamin B6 metabolism_Homo sapiens_hsa007500.39300479
90cAMP signaling pathway_Homo sapiens_hsa040240.37833412
91cGMP-PKG signaling pathway_Homo sapiens_hsa040220.36987235
92Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.35734323
93Oxytocin signaling pathway_Homo sapiens_hsa049210.35019046
94Central carbon metabolism in cancer_Homo sapiens_hsa052300.34314359
95Metabolic pathways_Homo sapiens_hsa011000.33938853
96Proteoglycans in cancer_Homo sapiens_hsa052050.33492309
97Melanogenesis_Homo sapiens_hsa049160.33121569
98Gap junction_Homo sapiens_hsa045400.32677288
99mTOR signaling pathway_Homo sapiens_hsa041500.32561233
100Pancreatic secretion_Homo sapiens_hsa049720.31387946
101MAPK signaling pathway_Homo sapiens_hsa040100.31230122
102Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.31130342
103Steroid biosynthesis_Homo sapiens_hsa001000.31080404
104Long-term depression_Homo sapiens_hsa047300.29423824
105Cholinergic synapse_Homo sapiens_hsa047250.28577709
106Insulin secretion_Homo sapiens_hsa049110.28561138
107Glioma_Homo sapiens_hsa052140.28548524
108Amphetamine addiction_Homo sapiens_hsa050310.27886955
109Glycerophospholipid metabolism_Homo sapiens_hsa005640.27578600
110Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.27326425
111Type II diabetes mellitus_Homo sapiens_hsa049300.27149588
112Ovarian steroidogenesis_Homo sapiens_hsa049130.26957612
113Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.25910832
114HIF-1 signaling pathway_Homo sapiens_hsa040660.25752657
115Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.24680169
116Vitamin digestion and absorption_Homo sapiens_hsa049770.24272122
117Longevity regulating pathway - mammal_Homo sapiens_hsa042110.23493345
118Folate biosynthesis_Homo sapiens_hsa007900.23431839
119Huntingtons disease_Homo sapiens_hsa050160.23323908
120Viral myocarditis_Homo sapiens_hsa054160.22982122
121Prion diseases_Homo sapiens_hsa050200.21472846
122Gastric acid secretion_Homo sapiens_hsa049710.21171887
123Vascular smooth muscle contraction_Homo sapiens_hsa042700.20474016
124GABAergic synapse_Homo sapiens_hsa047270.20351956
125Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.20133607
126Renin secretion_Homo sapiens_hsa049240.18894416
127Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.15818705
128Aldosterone synthesis and secretion_Homo sapiens_hsa049250.14574390
129alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.10820398
130Circadian entrainment_Homo sapiens_hsa047130.09583697

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