PPP1R3D

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Phosphorylation of serine and threonine residues in proteins is a crucial step in the regulation of many cellular functions ranging from hormonal regulation to cell division and even short-term memory. The level of phosphorylation is controlled by the opposing actions of protein kinases and protein phosphatases. Protein phosphatase 1 (PP1) is 1 of 4 major serine/threonine-specific protein phosphatases which have been identified in eukaryotic cells. PP1 associates with various regulatory subunits that dictate its subcellular localization and modulate its substrate specificity. Several subunits that target PP1 to glycogen have been identified. This gene encodes a glycogen-targeting subunit of PP1. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cardiac myofibril assembly (GO:0055003)5.83526837
2negative regulation of potassium ion transmembrane transporter activity (GO:1901017)5.48199511
3negative regulation of potassium ion transmembrane transport (GO:1901380)5.28484435
4positive regulation by symbiont of host defense response (GO:0052509)5.08667491
5modulation by symbiont of host defense response (GO:0052031)5.08667491
6modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.08667491
7modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.08667491
8positive regulation by organism of defense response of other organism involved in symbiotic interact5.08667491
9modulation by symbiont of host immune response (GO:0052553)5.08667491
10sarcomere organization (GO:0045214)4.98570586
11myofibril assembly (GO:0030239)4.87162028
12cardiac muscle cell development (GO:0055013)4.72239386
13positive regulation of gamma-delta T cell activation (GO:0046645)4.54154418
14negative regulation of cell killing (GO:0031342)4.53078799
15negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.53078799
16regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO4.52316262
17macrophage activation involved in immune response (GO:0002281)4.48934638
18detection of other organism (GO:0098543)4.48446833
19antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.48135888
20cardiac cell development (GO:0055006)4.44350806
21regulation of sequestering of triglyceride (GO:0010889)4.42271610
22response to peptidoglycan (GO:0032494)4.40106465
23cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.36236294
24cardiac muscle contraction (GO:0060048)4.26147832
25regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)4.25606571
26labyrinthine layer development (GO:0060711)4.22375475
27neutrophil activation involved in immune response (GO:0002283)4.22133259
28antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.17450641
29regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)4.15506259
30detection of molecule of bacterial origin (GO:0032490)4.14758532
31defense response to protozoan (GO:0042832)4.13139102
32carnitine shuttle (GO:0006853)4.12313001
33detection of bacterium (GO:0016045)4.11747900
34positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.10424559
35response to host immune response (GO:0052572)4.02765047
36response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.02765047
37regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)4.00805205
38regulation of interferon-beta biosynthetic process (GO:0045357)3.99100423
39regulation of relaxation of muscle (GO:1901077)3.95790455
40tricarboxylic acid cycle (GO:0006099)3.92953135
41detection of external biotic stimulus (GO:0098581)3.92189410
42regulation of actin filament-based movement (GO:1903115)3.90091783
43muscle filament sliding (GO:0030049)3.89602427
44actin-myosin filament sliding (GO:0033275)3.89602427
45regulation of membrane repolarization (GO:0060306)3.88182601
46antigen processing and presentation of endogenous antigen (GO:0019883)3.87304524
47cell communication involved in cardiac conduction (GO:0086065)3.85501681
48antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.84922180
49response to protozoan (GO:0001562)3.80069642
50response to host (GO:0075136)3.79301367
51response to host defenses (GO:0052200)3.79301367
52response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.79301367
53cell communication by electrical coupling (GO:0010644)3.76983220
54ventricular cardiac muscle cell action potential (GO:0086005)3.75196657
55positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.74292433
56regulation of T cell tolerance induction (GO:0002664)3.68155041
57striated muscle cell proliferation (GO:0014855)3.66560441
58heart process (GO:0003015)3.65431972
59heart contraction (GO:0060047)3.65431972
60proline biosynthetic process (GO:0006561)3.64025473
61regulation of mast cell degranulation (GO:0043304)3.62906672
62leukocyte aggregation (GO:0070486)3.59111399
63positive regulation of mast cell activation (GO:0033005)3.58610651
64regulation of mast cell activation involved in immune response (GO:0033006)3.58581864
65fatty acid transmembrane transport (GO:1902001)3.57707639
66regulation of gamma-delta T cell activation (GO:0046643)3.55700363
67neutrophil activation (GO:0042119)3.54279050
68negative regulation of interleukin-17 production (GO:0032700)3.53744263
69regulation of tolerance induction (GO:0002643)3.52835024
70negative regulation of interleukin-12 production (GO:0032695)3.49560830
71positive regulation of mast cell degranulation (GO:0043306)3.49101959
72positive regulation of mast cell activation involved in immune response (GO:0033008)3.49101959
73positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.47398560
74positive regulation of Cdc42 GTPase activity (GO:0043089)3.46993374
75actin-mediated cell contraction (GO:0070252)3.45216909
76heart trabecula formation (GO:0060347)3.41792377
77plasma membrane repair (GO:0001778)3.41676600
78regulation of B cell receptor signaling pathway (GO:0050855)3.39488022
79regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.39113355
80actomyosin structure organization (GO:0031032)3.37217845
81macrophage activation (GO:0042116)3.34911643
82relaxation of cardiac muscle (GO:0055119)3.32892791
83regulation of the force of heart contraction (GO:0002026)3.30809733
84negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.30402371
85immunoglobulin mediated immune response (GO:0016064)3.29979049
86regulation of leukocyte degranulation (GO:0043300)3.27938009
87detection of biotic stimulus (GO:0009595)3.26066355
88leukocyte migration involved in inflammatory response (GO:0002523)3.25013103
89regulation of striated muscle contraction (GO:0006942)3.24987887
90muscle cell proliferation (GO:0033002)3.24524756
91granulocyte activation (GO:0036230)3.23973091
92striated muscle contraction (GO:0006941)3.23483416
93lipopolysaccharide-mediated signaling pathway (GO:0031663)3.23019523
94necroptotic process (GO:0070266)3.22479508
95microglial cell activation (GO:0001774)3.19976630
96regulation of myeloid leukocyte mediated immunity (GO:0002886)3.19023699
97positive regulation of potassium ion transmembrane transport (GO:1901381)3.18721350
98production of molecular mediator involved in inflammatory response (GO:0002532)3.17918655
99positive regulation of leukocyte degranulation (GO:0043302)3.13927039
100negative regulation of T-helper cell differentiation (GO:0045623)3.13664523
101negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.13664523
102myeloid cell activation involved in immune response (GO:0002275)3.12329787
103regulation of gamma-delta T cell differentiation (GO:0045586)3.11773279
104regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.11709782
105regulation of cell communication by electrical coupling (GO:0010649)3.10482261
106cardiac muscle hypertrophy (GO:0003300)3.10273984
107regulation of sarcomere organization (GO:0060297)3.10184730
108regulation of fatty acid oxidation (GO:0046320)3.09496580
109negative regulation of lymphocyte mediated immunity (GO:0002707)3.08857730
110regulation of mast cell activation (GO:0033003)3.08468644
111programmed necrotic cell death (GO:0097300)3.07804691
112brown fat cell differentiation (GO:0050873)3.05780628
113response to interleukin-15 (GO:0070672)3.01071824
114type I interferon signaling pathway (GO:0060337)3.00631138
115cellular response to type I interferon (GO:0071357)3.00631138
116germinal center formation (GO:0002467)3.00076965
117regulation of cardiac muscle cell contraction (GO:0086004)2.99851003
118response to type I interferon (GO:0034340)2.99747918
119regulation of acyl-CoA biosynthetic process (GO:0050812)2.99640571
120B cell receptor signaling pathway (GO:0050853)2.97847516
121neutrophil mediated immunity (GO:0002446)2.97683779
122cardiac muscle tissue morphogenesis (GO:0055008)2.97157202
123sarcoplasmic reticulum calcium ion transport (GO:0070296)2.96270815
124positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.95355560
125positive regulation of regulated secretory pathway (GO:1903307)2.93267923
126actin filament-based movement (GO:0030048)2.93102616
127respiratory burst (GO:0045730)2.92883880
128regulation of female gonad development (GO:2000194)2.91535946
129striated muscle hypertrophy (GO:0014897)2.91516670
130negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.90939626
131carnitine transmembrane transport (GO:1902603)2.90773550
132regulation of cardioblast differentiation (GO:0051890)2.89928369
133regulation of cardiac muscle contraction (GO:0055117)2.89877162
134regulation of interleukin-17 production (GO:0032660)2.89663645
135response to muramyl dipeptide (GO:0032495)2.89040631
136adult heart development (GO:0007512)2.88658473
137positive regulation of interferon-alpha production (GO:0032727)2.88594013
138interferon-gamma secretion (GO:0072643)2.88096936
139proline transport (GO:0015824)2.87715015
140necrotic cell death (GO:0070265)2.85788225
141positive regulation of fatty acid oxidation (GO:0046321)2.85333514
142T-helper 1 type immune response (GO:0042088)2.83711420
143negative regulation of potassium ion transport (GO:0043267)2.82867940
144negative regulation of T cell mediated immunity (GO:0002710)2.82449089
145regulation of regulated secretory pathway (GO:1903305)2.81486866
146positive regulation of T cell mediated cytotoxicity (GO:0001916)2.81010122
147regulation of T cell mediated cytotoxicity (GO:0001914)2.80332713
148membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.78231313
149regulation of secondary heart field cardioblast proliferation (GO:0003266)2.78119811
150regulation of cardioblast proliferation (GO:0003264)2.78119811
151positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.78094774
152ventricular cardiac muscle cell development (GO:0055015)2.77122155
153positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.76453339
154cellular extravasation (GO:0045123)2.74621549
155ventricular cardiac muscle tissue morphogenesis (GO:0055010)2.74427700
156negative regulation of toll-like receptor signaling pathway (GO:0034122)2.73935627
157potassium ion export (GO:0071435)2.72356011
158regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.72312269
159cellular response to interleukin-15 (GO:0071350)2.71909330
160positive regulation of cellular amide metabolic process (GO:0034250)2.71777997
161NADH metabolic process (GO:0006734)2.71505390
162regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.70473559
163antigen processing and presentation via MHC class Ib (GO:0002475)2.70459390
164cardiac muscle cell action potential involved in contraction (GO:0086002)2.69567263
165regulation of interferon-alpha production (GO:0032647)2.68371692
166regulation of coenzyme metabolic process (GO:0051196)2.67878426
167regulation of cofactor metabolic process (GO:0051193)2.67878426
168negative regulation of leukocyte mediated immunity (GO:0002704)2.67719721
169positive regulation of toll-like receptor signaling pathway (GO:0034123)2.66510291
170cardiac muscle cell action potential (GO:0086001)2.65039240
171regulation of T cell mediated immunity (GO:0002709)2.63392917
172regulation of T-helper 2 cell differentiation (GO:0045628)2.63052346
173positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.62257135
174negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.62042135
175activation of protein kinase A activity (GO:0034199)2.60359020
176muscle tissue morphogenesis (GO:0060415)2.58566761
177negative regulation of protein localization to cell surface (GO:2000009)2.58076893
178striated muscle cell development (GO:0055002)2.58005399
179detection of calcium ion (GO:0005513)2.57889807
180regulation of glucose import in response to insulin stimulus (GO:2001273)2.57740097
181muscle hypertrophy (GO:0014896)2.56945034
182carnitine transport (GO:0015879)2.55385646
183amino-acid betaine transport (GO:0015838)2.55385646
184regulation of skeletal muscle contraction (GO:0014819)2.55141675
185regulation of cAMP-dependent protein kinase activity (GO:2000479)2.52893631
186bundle of His cell to Purkinje myocyte communication (GO:0086069)2.49523342
187negative regulation of ion transmembrane transporter activity (GO:0032413)2.48552425
188membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.47239902
189white fat cell differentiation (GO:0050872)2.46967929
190regulation of heart contraction (GO:0008016)2.46453227
191sequestering of metal ion (GO:0051238)2.46441493
192intracellular lipid transport (GO:0032365)2.46032261
193negative regulation of cardiac muscle hypertrophy (GO:0010614)2.44948807
194regulation of heart rate (GO:0002027)2.43200475
195relaxation of muscle (GO:0090075)2.41636653
196response to epinephrine (GO:0071871)2.39799488
197relaxation of smooth muscle (GO:0044557)2.36807211
198membrane repolarization during action potential (GO:0086011)2.35673371
199negative regulation of muscle hypertrophy (GO:0014741)2.35562612

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.32366240
2IRF8_22096565_ChIP-ChIP_GC-B_Human3.76274873
3GATA1_22025678_ChIP-Seq_K562_Human3.52842799
4IRF8_21731497_ChIP-ChIP_J774_Mouse3.05534732
5SMAD_19615063_ChIP-ChIP_OVARY_Human3.04279768
6VDR_21846776_ChIP-Seq_THP-1_Human2.77546579
7FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.76116486
8MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.74052658
9EP300_21415370_ChIP-Seq_HL-1_Mouse2.69593170
10IRF8_27001747_Chip-Seq_BMDM_Mouse2.67245733
11RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.47009534
12SCL_19346495_ChIP-Seq_HPC-7_Human2.42873709
13EZH2_22144423_ChIP-Seq_EOC_Human2.34243755
14CDX2_19796622_ChIP-Seq_MESCs_Mouse2.29844181
15RUNX_20019798_ChIP-Seq_JUKART_Human2.29387768
16STAT6_21828071_ChIP-Seq_BEAS2B_Human2.28306788
17BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.27959900
18STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.27725679
19BRD4_27068464_Chip-Seq_AML-cells_Mouse2.23645052
20IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.14575521
21ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.10565565
22FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.09999954
23SPI1_23547873_ChIP-Seq_NB4_Human2.07985610
24MYC_22102868_ChIP-Seq_BL_Human1.95040499
25TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.93156338
26RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.92403876
27E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.91261794
28EGR1_19374776_ChIP-ChIP_THP-1_Human1.90075665
29RUNX1_22412390_ChIP-Seq_EML_Mouse1.88139377
30TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.87215441
31* TBX20_22080862_ChIP-Seq_HEART_Mouse1.85729229
32* TBX20_22328084_ChIP-Seq_HEART_Mouse1.85729229
33IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.84653172
34VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.84113570
35BP1_19119308_ChIP-ChIP_Hs578T_Human1.81348166
36KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.81295584
37MAF_26560356_Chip-Seq_TH1_Human1.78732364
38FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.72225698
39RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.72111913
40ESR1_21235772_ChIP-Seq_MCF-7_Human1.70615513
41MYB_26560356_Chip-Seq_TH2_Human1.69244482
42MYB_21317192_ChIP-Seq_ERMYB_Mouse1.68344114
43* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.65940537
44TP63_17297297_ChIP-ChIP_HaCaT_Human1.65591518
45STAT4_19710469_ChIP-ChIP_TH1__Mouse1.65155750
46SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.64191067
47SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.58584789
48NR3C1_23031785_ChIP-Seq_PC12_Mouse1.56190774
49GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.53890377
50TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.52604860
51IGF1R_20145208_ChIP-Seq_DFB_Human1.52373971
52UTX_26944678_Chip-Seq_JUKART_Human1.49511179
53EZH2_18974828_ChIP-Seq_MESCs_Mouse1.49144269
54RNF2_18974828_ChIP-Seq_MESCs_Mouse1.49144269
55KDM2B_26808549_Chip-Seq_SUP-B15_Human1.48982942
56SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.48725228
57MYB_26560356_Chip-Seq_TH1_Human1.48514333
58IKZF1_21737484_ChIP-ChIP_HCT116_Human1.46348769
59RACK7_27058665_Chip-Seq_MCF-7_Human1.46039642
60WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.45834592
61* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.45626578
62* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.44326462
63SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.43860706
64EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.43189324
65KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.40969679
66RUNX1_27514584_Chip-Seq_MCF-7_Human1.39014518
67NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.38008632
68SPI1_23127762_ChIP-Seq_K562_Human1.37355062
69GATA2_22383799_ChIP-Seq_G1ME_Mouse1.36150104
70* JARID2_20064375_ChIP-Seq_MESCs_Mouse1.36061427
71SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.35899312
72TP53_16413492_ChIP-PET_HCT116_Human1.34734655
73ELK3_25401928_ChIP-Seq_HUVEC_Human1.34710377
74CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.33893165
75VDR_24787735_ChIP-Seq_THP-1_Human1.33646950
76ESR1_20079471_ChIP-ChIP_T-47D_Human1.33352662
77LXR_22292898_ChIP-Seq_THP-1_Human1.32633718
78CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.31699294
79EZH2_27304074_Chip-Seq_ESCs_Mouse1.31432384
80GATA1_19941827_ChIP-Seq_MEL_Mouse1.31075311
81* RNF2_27304074_Chip-Seq_ESCs_Mouse1.30709267
82TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.29219962
83PU_27001747_Chip-Seq_BMDM_Mouse1.26831211
84MAF_26560356_Chip-Seq_TH2_Human1.26031540
85GATA1_22383799_ChIP-Seq_G1ME_Mouse1.25926474
86RXR_22108803_ChIP-Seq_LS180_Human1.25922220
87EZH2_27294783_Chip-Seq_ESCs_Mouse1.24630682
88BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.23211751
89CJUN_26792858_Chip-Seq_BT549_Human1.22603515
90TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.22291836
91* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.20620283
92* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.18336132
93GBX2_23144817_ChIP-Seq_PC3_Human1.17941978
94PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.17497264
95Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.17346178
96MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.15966720
97FOXO3_23340844_ChIP-Seq_DLD1_Human1.15744041
98KDM2B_26808549_Chip-Seq_K562_Human1.15031144
99BCAT_22108803_ChIP-Seq_LS180_Human1.13610299
100ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.13348681
101CLOCK_20551151_ChIP-Seq_293T_Human1.13123681
102SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.12534435
103PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.11898414
104GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.11330380
105KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.10935931
106GATA3_27048872_Chip-Seq_THYMUS_Human1.09744107
107ESR2_21235772_ChIP-Seq_MCF-7_Human1.09670018
108AHR_22903824_ChIP-Seq_MCF-7_Human1.09466558
109DROSHA_22980978_ChIP-Seq_HELA_Human1.08963786
110ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.07746066
111GATA1_19941826_ChIP-Seq_K562_Human1.07571059
112TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.07512191
113GATA2_21666600_ChIP-Seq_HMVEC_Human1.06689575
114KDM2B_26808549_Chip-Seq_JURKAT_Human1.06423897
115LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.06194578
116PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.05455238
117AR_21572438_ChIP-Seq_LNCaP_Human1.04058448
118MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.03461385
119PPAR_26484153_Chip-Seq_NCI-H1993_Human1.03444784
120PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.03371919
121GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.03328066
122CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.03110785
123NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.03056733
124SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.02740352
125SUZ12_27294783_Chip-Seq_ESCs_Mouse1.02709834
126KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.02151860
127CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.01226751
128SOX2_27498859_Chip-Seq_STOMACH_Mouse1.00697938
129SMAD3_21741376_ChIP-Seq_HESCs_Human1.00621915
130TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.99335793
131* SOX2_21211035_ChIP-Seq_LN229_Gbm0.99247014
132PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.98785585
133STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.98566721
134RARB_27405468_Chip-Seq_BRAIN_Mouse0.98406626
135CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.98294760
136SMAD4_21799915_ChIP-Seq_A2780_Human0.97489606
137CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.97300746
138GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.96344317
139MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.96135756
140ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.95850596
141NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.95510436
142ZNF217_24962896_ChIP-Seq_MCF-7_Human0.94824878
143AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.93677771
144* FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.92543536
145PIAS1_25552417_ChIP-Seq_VCAP_Human0.92097188
146FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.91979183
147STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.91661561
148SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.91055799
149DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.90755438
150KDM2B_26808549_Chip-Seq_DND41_Human0.90218474
151AR_25329375_ChIP-Seq_VCAP_Human0.89949192
152NRF2_20460467_ChIP-Seq_MEFs_Mouse0.89890843
153NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.89890843
154PU.1_20513432_ChIP-Seq_Bcells_Mouse0.89430617
155CTBP2_25329375_ChIP-Seq_LNCAP_Human0.89277336
156P63_26484246_Chip-Seq_KERATINOCYTES_Human0.89107965
157SMRT_27268052_Chip-Seq_Bcells_Human0.87982081
158ISL1_27105846_Chip-Seq_CPCs_Mouse0.87503751
159SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.86886103
160PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.86582295
161TCF7_22412390_ChIP-Seq_EML_Mouse0.86464326
162GATA1_19941827_ChIP-Seq_MEL86_Mouse0.86185031
163PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.86076844
164GATA2_19941826_ChIP-Seq_K562_Human0.85468065
165EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.84444840
166ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.84422570
167TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.83803213
168POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.83803213
169RING1B_27294783_Chip-Seq_ESCs_Mouse0.83336542
170TP63_23658742_ChIP-Seq_EP156T_Human0.82836859
171* GATA4_21415370_ChIP-Seq_HL-1_Mouse0.82798389
172VDR_24763502_ChIP-Seq_THP-1_Human0.81964848

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis7.56416743
2MP0003646_muscle_fatigue4.30700523
3MP0004084_abnormal_cardiac_muscle3.89170388
4MP0004215_abnormal_myocardial_fiber3.74079516
5MP0004510_myositis3.44614690
6MP0000751_myopathy3.40287667
7MP0004036_abnormal_muscle_relaxation2.90833085
8MP0003137_abnormal_impulse_conducting2.74195996
9MP0002972_abnormal_cardiac_muscle2.73479378
10MP0004130_abnormal_muscle_cell2.66753975
11MP0003828_pulmonary_edema2.66457857
12MP0004185_abnormal_adipocyte_glucose2.60662432
13MP0001835_abnormal_antigen_presentation2.55097625
14MP0003950_abnormal_plasma_membrane2.51561289
15MP0001790_abnormal_immune_system2.49942257
16MP0005387_immune_system_phenotype2.49942257
17MP0004381_abnormal_hair_follicle2.48032916
18MP0005000_abnormal_immune_tolerance2.46702633
19MP0005025_abnormal_response_to2.42239933
20MP0005330_cardiomyopathy2.41602297
21MP0004087_abnormal_muscle_fiber2.39602785
22MP0002148_abnormal_hypersensitivity_rea2.34641227
23MP0009785_altered_susceptibility_to2.34333100
24MP0001800_abnormal_humoral_immune2.32577406
25MP0006082_CNS_inflammation2.30865891
26MP0000685_abnormal_immune_system2.29760550
27MP0005620_abnormal_muscle_contractility2.29463446
28MP0005670_abnormal_white_adipose2.28379334
29MP0002452_abnormal_antigen_presenting2.15807085
30MP0005666_abnormal_adipose_tissue2.09421661
31MP0002723_abnormal_immune_serum2.08514555
32MP0004484_altered_response_of2.07688897
33MP0002420_abnormal_adaptive_immunity2.07550305
34MP0006138_congestive_heart_failure2.06338085
35MP0001819_abnormal_immune_cell2.05786350
36MP0001544_abnormal_cardiovascular_syste2.04786264
37MP0005385_cardiovascular_system_phenoty2.04786264
38MP0010630_abnormal_cardiac_muscle2.01478526
39MP0000749_muscle_degeneration1.98654128
40MP0008775_abnormal_heart_ventricle1.98380811
41MP0003183_abnormal_peptide_metabolism1.96508822
42MP0005671_abnormal_response_to1.94569045
43MP0002405_respiratory_system_inflammati1.94318551
44MP0000343_altered_response_to1.91792058
45MP0003221_abnormal_cardiomyocyte_apopto1.88925443
46MP0005451_abnormal_body_composition1.82449789
47MP0004085_abnormal_heartbeat1.81033571
48MP0005167_abnormal_blood-brain_barrier1.79021684
49MP0002877_abnormal_melanocyte_morpholog1.78847398
50MP0004947_skin_inflammation1.74702432
51MP0002909_abnormal_adrenal_gland1.74222068
52MP0003763_abnormal_thymus_physiology1.73306634
53MP0002106_abnormal_muscle_physiology1.72583030
54MP0005076_abnormal_cell_differentiation1.68185374
55MP0002396_abnormal_hematopoietic_system1.66367910
56MP0000465_gastrointestinal_hemorrhage1.65161104
57MP0000750_abnormal_muscle_regeneration1.64828632
58MP0001873_stomach_inflammation1.61387993
59MP0005464_abnormal_platelet_physiology1.57909936
60MP0002998_abnormal_bone_remodeling1.57755918
61MP0002398_abnormal_bone_marrow1.56583971
62MP0010155_abnormal_intestine_physiology1.55544616
63MP0000716_abnormal_immune_system1.54737152
64MP0002132_abnormal_respiratory_system1.53492321
65MP0004264_abnormal_extraembryonic_tissu1.51600107
66MP0009278_abnormal_bone_marrow1.51027385
67MP0001845_abnormal_inflammatory_respons1.49191462
68MP0003303_peritoneal_inflammation1.48526899
69MP0005058_abnormal_lysosome_morphology1.47758784
70MP0001851_eye_inflammation1.47730533
71MP0000759_abnormal_skeletal_muscle1.47550695
72MP0003279_aneurysm1.42425369
73MP0005075_abnormal_melanosome_morpholog1.41922835
74MP0000858_altered_metastatic_potential1.41824945
75MP0008260_abnormal_autophagy1.38571958
76MP0008469_abnormal_protein_level1.36601863
77MP0005164_abnormal_response_to1.36429781
78MP0002722_abnormal_immune_system1.30723397
79MP0003091_abnormal_cell_migration1.30511870
80MP0010352_gastrointestinal_tract_polyps1.29728761
81MP0003172_abnormal_lysosome_physiology1.28839252
82MP0005375_adipose_tissue_phenotype1.28223804
83MP0003453_abnormal_keratinocyte_physiol1.27231642
84MP0004145_abnormal_muscle_electrophysio1.26897320
85MP0002971_abnormal_brown_adipose1.25429497
86MP0000689_abnormal_spleen_morphology1.25310194
87MP0003075_altered_response_to1.25246086
88MP0004859_abnormal_synaptic_plasticity1.24015859
89MP0003656_abnormal_erythrocyte_physiolo1.23964318
90MP0002429_abnormal_blood_cell1.21027090
91MP0005397_hematopoietic_system_phenotyp1.20977618
92MP0001545_abnormal_hematopoietic_system1.20977618
93MP0005369_muscle_phenotype1.20155722
94MP0000703_abnormal_thymus_morphology1.16268239
95MP0010234_abnormal_vibrissa_follicle1.14910356
96MP0002269_muscular_atrophy1.14772653
97MP0003191_abnormal_cellular_cholesterol1.13263481
98MP0003566_abnormal_cell_adhesion1.12335908
99MP0003567_abnormal_fetal_cardiomyocyte1.12134540
100MP0001849_ear_inflammation1.12093059
101MP0005310_abnormal_salivary_gland1.11603110
102MP0002332_abnormal_exercise_endurance1.10792925
103MP0009333_abnormal_splenocyte_physiolog1.10751622
104MP0002166_altered_tumor_susceptibility1.10188377
105MP0003866_abnormal_defecation1.07503040
106MP0006036_abnormal_mitochondrial_physio1.05816131
107MP0003436_decreased_susceptibility_to1.05217562
108MP0002277_abnormal_respiratory_mucosa1.04990924
109MP0005390_skeleton_phenotype1.02935510
110MP0009765_abnormal_xenobiotic_induced1.02521582
111MP0002796_impaired_skin_barrier1.01157815
112MP0009115_abnormal_fat_cell0.98355281
113MP0010368_abnormal_lymphatic_system0.97194975
114MP0002234_abnormal_pharynx_morphology0.94816155
115MP0009840_abnormal_foam_cell0.92018584
116MP0000013_abnormal_adipose_tissue0.90493191
117MP0006072_abnormal_retinal_apoptosis0.90297648
118MP0005595_abnormal_vascular_smooth0.89397215
119MP0000681_abnormal_thyroid_gland0.87267045
120MP0001727_abnormal_embryo_implantation0.86773750
121MP0000266_abnormal_heart_morphology0.86616330
122MP0000747_muscle_weakness0.85025866
123MP0003448_altered_tumor_morphology0.84909113
124MP0005535_abnormal_body_temperature0.84321069
125MP0004270_analgesia0.81528037
126MP0009764_decreased_sensitivity_to0.81373208
127MP0002127_abnormal_cardiovascular_syste0.81309463
128MP0005083_abnormal_biliary_tract0.81280055
129MP0000678_abnormal_parathyroid_gland0.80253413
130MP0005165_increased_susceptibility_to0.79496895
131MP0000230_abnormal_systemic_arterial0.78130959
132MP0003045_fibrosis0.77407432
133MP0000249_abnormal_blood_vessel0.76834586
134MP0008874_decreased_physiological_sensi0.76165804
135MP0005319_abnormal_enzyme/_coenzyme0.75259718
136MP0002009_preneoplasia0.75054677
137MP0009763_increased_sensitivity_to0.74868105
138MP0000371_diluted_coat_color0.73271520
139MP0003705_abnormal_hypodermis_morpholog0.71983920
140MP0004272_abnormal_basement_membrane0.71880233
141MP0005187_abnormal_penis_morphology0.71468591
142MP0005166_decreased_susceptibility_to0.71369096
143MP0002098_abnormal_vibrissa_morphology0.71211801
144MP0003638_abnormal_response/metabolism_0.70218423
145MP0002078_abnormal_glucose_homeostasis0.68719056
146MP0005334_abnormal_fat_pad0.68297520
147MP0003795_abnormal_bone_structure0.67659031
148MP0001879_abnormal_lymphatic_vessel0.67292550
149MP0004883_abnormal_blood_vessel0.66818968
150MP0002295_abnormal_pulmonary_circulatio0.66065850
151MP0004858_abnormal_nervous_system0.62937565
152MP0008438_abnormal_cutaneous_collagen0.61887640
153MP0000569_abnormal_digit_pigmentation0.61176096
154MP0008961_abnormal_basal_metabolism0.61040248
155MP0001970_abnormal_pain_threshold0.57439033
156MP0000733_abnormal_muscle_development0.56347916
157MP0001853_heart_inflammation0.54203236
158MP0003329_amyloid_beta_deposits0.54116328
159MP0005646_abnormal_pituitary_gland0.53793649
160MP0002419_abnormal_innate_immunity0.52855057
161MP0002128_abnormal_blood_circulation0.52274787
162MP0003300_gastrointestinal_ulcer0.51982807
163MP0004233_abnormal_muscle_weight0.51641044
164MP0005448_abnormal_energy_balance0.50294242
165MP0001614_abnormal_blood_vessel0.49820589
166MP0002735_abnormal_chemical_nociception0.49421371
167MP0003635_abnormal_synaptic_transmissio0.49336125
168MP0005386_behavior/neurological_phenoty0.49016878
169MP0004924_abnormal_behavior0.49016878
170MP0004808_abnormal_hematopoietic_stem0.48470854
171MP0003690_abnormal_glial_cell0.48015966
172MP0003724_increased_susceptibility_to0.47975446
173MP0001533_abnormal_skeleton_physiology0.47764383
174MP0000767_abnormal_smooth_muscle0.47612151

Predicted human phenotypes

RankGene SetZ-score
1Sudden death (HP:0001699)6.40887417
2Primary atrial arrhythmia (HP:0001692)5.58732192
3Atrial fibrillation (HP:0005110)5.41996785
4Supraventricular tachycardia (HP:0004755)5.38660320
5Supraventricular arrhythmia (HP:0005115)5.30457634
6Atrioventricular block (HP:0001678)5.28234547
7Ventricular tachycardia (HP:0004756)5.26142456
8Subaortic stenosis (HP:0001682)4.72522625
9Abnormality of the left ventricular outflow tract (HP:0011103)4.72522625
10Lipoatrophy (HP:0100578)4.56227870
11Syncope (HP:0001279)4.45216403
12Asymmetric septal hypertrophy (HP:0001670)4.44381916
13Heart block (HP:0012722)4.43160928
14Bundle branch block (HP:0011710)4.41603420
15Myositis (HP:0100614)4.35274121
16Orchitis (HP:0100796)4.31328158
17Calf muscle hypertrophy (HP:0008981)4.26835645
18Abnormal atrioventricular conduction (HP:0005150)4.10823380
19Exercise-induced myalgia (HP:0003738)4.04857002
20Ventricular arrhythmia (HP:0004308)4.04133516
21Optic neuritis (HP:0100653)3.90875694
22Retrobulbar optic neuritis (HP:0100654)3.90875694
23Ventricular fibrillation (HP:0001663)3.87759217
24Abnormality of the calf musculature (HP:0001430)3.66666832
25Muscle hypertrophy of the lower extremities (HP:0008968)3.65243674
26Dilated cardiomyopathy (HP:0001644)3.56059733
27Prolonged QT interval (HP:0001657)3.54372607
28Recurrent gram-negative bacterial infections (HP:0005420)3.53205847
29Myoglobinuria (HP:0002913)3.50383398
30Exercise-induced muscle cramps (HP:0003710)3.47501275
31Palpitations (HP:0001962)3.42968143
32Keratoconjunctivitis sicca (HP:0001097)3.35227666
33Spontaneous hematomas (HP:0007420)3.34657024
34Slow saccadic eye movements (HP:0000514)3.33531299
35Recurrent skin infections (HP:0001581)3.24475066
36Recurrent fungal infections (HP:0002841)3.17779159
37Gastrointestinal infarctions (HP:0005244)3.16088653
38Abnormal EKG (HP:0003115)3.08937619
39Muscle fiber splitting (HP:0003555)3.05751808
40Keratoconjunctivitis (HP:0001096)3.04358808
41Stomatitis (HP:0010280)3.00635719
42Hyporeflexia of lower limbs (HP:0002600)2.97337186
43Mediastinal lymphadenopathy (HP:0100721)2.94155660
44Gingivitis (HP:0000230)2.92416724
45Urticaria (HP:0001025)2.91193863
46Male infertility (HP:0003251)2.88110123
47Right ventricular cardiomyopathy (HP:0011663)2.87925915
48Obstructive lung disease (HP:0006536)2.84869494
49Chronic obstructive pulmonary disease (HP:0006510)2.84869494
50Chronic mucocutaneous candidiasis (HP:0002728)2.84628076
51Recurrent cutaneous fungal infections (HP:0011370)2.84628076
52Conjunctival hamartoma (HP:0100780)2.83993441
53Meningitis (HP:0001287)2.83770018
54Abnormal delayed hypersensitivity skin test (HP:0002963)2.82804924
55Left ventricular hypertrophy (HP:0001712)2.75784516
56Elevated erythrocyte sedimentation rate (HP:0003565)2.74465970
57Pheochromocytoma (HP:0002666)2.68326428
58Increased IgE level (HP:0003212)2.65380117
59Metaphyseal cupping (HP:0003021)2.61435102
60Cellulitis (HP:0100658)2.61116849
61Sudden cardiac death (HP:0001645)2.57408655
62Vasculitis (HP:0002633)2.55698241
63Recurrent abscess formation (HP:0002722)2.48005152
64Hypoglycemic coma (HP:0001325)2.43498714
65Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.43483363
66Sparse lateral eyebrow (HP:0005338)2.43148428
67Arterial thrombosis (HP:0004420)2.40858258
68Insulin-resistant diabetes mellitus (HP:0000831)2.40098747
69Loss of speech (HP:0002371)2.39274302
70Myotonia (HP:0002486)2.36726293
71Hemoptysis (HP:0002105)2.34032036
72Chest pain (HP:0100749)2.32723332
73Pustule (HP:0200039)2.32376040
74Episodic fever (HP:0001954)2.31989739
75Encephalitis (HP:0002383)2.30389241
76Neuroendocrine neoplasm (HP:0100634)2.30230751
77Broad metatarsal (HP:0001783)2.28660949
78Bone cyst (HP:0012062)2.26798316
79EMG: myopathic abnormalities (HP:0003458)2.26526545
80Increased variability in muscle fiber diameter (HP:0003557)2.25902558
81Ketoacidosis (HP:0001993)2.22825357
82Recurrent viral infections (HP:0004429)2.21729166
83Enlarged penis (HP:0000040)2.19674184
84Subacute progressive viral hepatitis (HP:0006572)2.18266588
85Difficulty running (HP:0009046)2.18000615
86Peritonitis (HP:0002586)2.17873518
87Scapular winging (HP:0003691)2.16821043
88Absent frontal sinuses (HP:0002688)2.15940523
89T lymphocytopenia (HP:0005403)2.15521913
90Hamartoma of the eye (HP:0010568)2.14868231
91Gastrointestinal inflammation (HP:0004386)2.14034085
92Hematochezia (HP:0002573)2.13113658
93Pulmonary infiltrates (HP:0002113)2.12972716
94Papilledema (HP:0001085)2.12056075
95Amyloidosis (HP:0011034)2.09919522
96Nausea (HP:0002018)2.09378690
97Abnormality of liposaccharide metabolism (HP:0010968)2.08314081
98Abnormality of glycosphingolipid metabolism (HP:0004343)2.08314081
99Abnormality of glycolipid metabolism (HP:0010969)2.08314081
100Increased muscle lipid content (HP:0009058)2.07830321
101Increased cerebral lipofuscin (HP:0011813)2.07600352
102Preauricular pit (HP:0004467)2.07197549
103Periauricular skin pits (HP:0100277)2.07197549
104Cerebral aneurysm (HP:0004944)2.07065834
105Type 1 muscle fiber predominance (HP:0003803)2.06951564
106Lip pit (HP:0100267)2.06794957
107Neck muscle weakness (HP:0000467)2.06679668
108Osteomyelitis (HP:0002754)2.06589966
109Rhabdomyolysis (HP:0003201)2.06307138
110Prolonged bleeding time (HP:0003010)2.06184617
111Bulbar palsy (HP:0001283)2.04647341
112Inflammation of the large intestine (HP:0002037)2.04141397
113Gingival bleeding (HP:0000225)2.04124444
114Multiple enchondromatosis (HP:0005701)2.01839780
115Hypochromic anemia (HP:0001931)2.00327180
116Premature loss of primary teeth (HP:0006323)1.99384479
117Syringomyelia (HP:0003396)1.98339510
118Spinal cord lesions (HP:0100561)1.98339510
119Gastrointestinal stroma tumor (HP:0100723)1.97872333
120Epistaxis (HP:0000421)1.97780340
121Anorexia (HP:0002039)1.97735708
122Neoplasm of the adrenal gland (HP:0100631)1.97527170
123Micronodular cirrhosis (HP:0001413)1.96886527
124Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.96321357
125Abnormality of the endocardium (HP:0004306)1.95570843
126Hyperglycemia (HP:0003074)1.95436295
127Abnormality of T cell number (HP:0011839)1.94543352
128Hypoplastic left heart (HP:0004383)1.92879742
129Recurrent bacterial skin infections (HP:0005406)1.91877670
130Gangrene (HP:0100758)1.91399012
131Cheilitis (HP:0100825)1.89898535
132Dysostosis multiplex (HP:0000943)1.89693571
133Pulmonary embolism (HP:0002204)1.89638140
134Oligomenorrhea (HP:0000876)1.88915061
135Distal lower limb muscle weakness (HP:0009053)1.88776514
136Abnormality of alanine metabolism (HP:0010916)1.87666174
137Hyperalaninemia (HP:0003348)1.87666174
138Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.87666174
139Centrally nucleated skeletal muscle fibers (HP:0003687)1.87384602
140Dysmetric saccades (HP:0000641)1.86594804
141Malnutrition (HP:0004395)1.86563924
142Eczematoid dermatitis (HP:0000976)1.85712530
143Periodontitis (HP:0000704)1.85383846
144Visual hallucinations (HP:0002367)1.84393758
145Congestive heart failure (HP:0001635)1.83667609
146Abnormal platelet volume (HP:0011876)1.82996305
147Neonatal death (HP:0003811)1.82307471
148Abnormality of skeletal muscle fiber size (HP:0012084)1.82188018
149Ankle contracture (HP:0006466)1.81671607
150Palmoplantar keratoderma (HP:0000982)1.81622560
151Abnormal vertebral ossification (HP:0100569)1.80398977
152Concave nail (HP:0001598)1.80233384
153Scanning speech (HP:0002168)1.79537246
154Sepsis (HP:0100806)1.79017558
155Viral hepatitis (HP:0006562)1.78552075
156Colitis (HP:0002583)1.78125980
157Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.76255471
158Abnormality of the frontal sinuses (HP:0002687)1.76126414
159Skin ulcer (HP:0200042)1.76085462
160Absent rod-and cone-mediated responses on ERG (HP:0007688)1.75724121
161Hepatic necrosis (HP:0002605)1.74975035
162Gowers sign (HP:0003391)1.73840256
163Increased neuronal autofluorescent lipopigment (HP:0002074)1.73664582
164Increased serum ferritin (HP:0003281)1.72354803
165Leukocytosis (HP:0001974)1.71086547
166Spondylolisthesis (HP:0003302)1.70649604
167Morphological abnormality of the middle ear (HP:0008609)1.70168422
168Achilles tendon contracture (HP:0001771)1.66055824
169Muscle stiffness (HP:0003552)1.63024679
170Mildly elevated creatine phosphokinase (HP:0008180)1.62659420
171Lymphangioma (HP:0100764)1.62659170
172Cerebral hemorrhage (HP:0001342)1.61817729
173Papillary thyroid carcinoma (HP:0002895)1.57213215
174Abnormality of macrophages (HP:0004311)1.57051223
175Increased connective tissue (HP:0009025)1.54828581
176Aneurysm (HP:0002617)1.54033303
177Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.51327864
178Short 1st metacarpal (HP:0010034)1.51327864
179Decreased circulating renin level (HP:0003351)1.47996287
180Furrowed tongue (HP:0000221)1.47930253
181Progressive inability to walk (HP:0002505)1.47827892
182Childhood onset (HP:0011463)1.47503299
183Striae distensae (HP:0001065)1.46403575
184EMG: neuropathic changes (HP:0003445)1.46293246
185Renal cortical cysts (HP:0000803)1.45848982
186Polycythemia (HP:0001901)1.44135785

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB33.76787859
2KSR23.53798307
3TAOK32.89059201
4PRPF4B2.72791972
5MOS2.58399561
6BLK2.47628262
7PKN22.43290256
8MAP3K62.39579491
9CSK2.18834637
10MAP3K92.18114804
11TTN2.16407837
12GRK62.10365929
13MAP4K12.02865740
14LATS22.00831586
15TNK21.97694793
16IRAK11.95838391
17MATK1.90764066
18SIK11.89841128
19MYLK1.88296808
20TIE11.84951796
21RIPK41.84367127
22ZAP701.82566509
23LATS11.80908273
24LMTK21.79610529
25DMPK1.77813961
26IRAK31.75641682
27PHKG21.69864011
28PHKG11.69864011
29STK241.69128612
30MAP3K131.68642487
31OBSCN1.66444682
32BMPR21.63263541
33MAP3K31.63128647
34PRKD31.62411131
35MUSK1.61752226
36CDK121.59607611
37MAP3K141.56332318
38ABL21.49397482
39TRPM71.49311385
40PAK61.46146852
41PDGFRA1.43434081
42JAK31.42733868
43CAMKK21.42705287
44IKBKE1.40014329
45YES11.36289772
46TAOK11.26703998
47PAK31.26550824
48CAMKK11.26139624
49MAP2K31.25620914
50CSF1R1.24775989
51EPHB11.23356458
52TBK11.16273583
53RET1.14774112
54BTK1.13830015
55IRAK41.11678782
56RIPK11.10640586
57MAP2K41.10470413
58RPS6KB21.06299998
59CAMK1D1.05601693
60PDK41.05436629
61PDK31.05436629
62GRK51.04706087
63TGFBR21.03710291
64PIK3CA1.02207509
65EPHA31.01770442
66PRKCH1.01462113
67GRK71.01169470
68FES1.00668528
69EPHA40.96698290
70MAP3K10.96567633
71MAPKAPK30.96299140
72MAP3K20.95549375
73IRAK20.93895381
74SYK0.92416504
75MAP3K110.88996653
76TAOK20.88689917
77PRKAA20.86699327
78RAF10.86591054
79LYN0.84571958
80PDPK10.83971796
81EPHA20.82210080
82NEK60.80775556
83RPS6KC10.79915559
84RPS6KL10.79915559
85STK38L0.79888822
86MAP2K10.78962636
87CAMK1G0.78463149
88MAP3K50.78128164
89CHUK0.77907107
90ERN10.77415750
91FGR0.76655509
92LRRK20.75962427
93LCK0.75607707
94PRKD10.75283617
95KSR10.74485184
96NTRK30.74225000
97PDK10.71841551
98PRKG20.71468136
99HIPK20.68716021
100IKBKB0.68177751
101SIK30.68124044
102RPS6KA60.67405958
103PTK2B0.66946784
104PRKD20.66586817
105JAK20.65586049
106ILK0.63744772
107FGFR40.63245740
108NTRK10.62904603
109MAPK120.62637669
110TRIM280.61420130
111PTK60.60476169
112SMG10.60368534
113PTK20.60213328
114CDC42BPA0.58115316
115STK100.57547588
116CAMK2A0.57120831
117KIT0.55680624
118HCK0.55594257
119ADRBK10.54859806
120ROCK10.54782461
121MAPKAPK20.54679431
122ALK0.54385123
123PRKAA10.53620475
124TYK20.53177153
125TEC0.52094348
126CAMK10.51978383
127MAPK130.51297779
128RPS6KA20.49285777
129JAK10.48573010
130CDK60.48382537
131MARK20.48104725
132FGFR30.47986632
133CAMK2D0.47810029
134ITK0.47323431
135MARK10.46783443
136DYRK1B0.46523934
137MAPK70.46131150
138STK110.45325632
139MAP2K60.45254258
140SGK30.44913275
141STK380.44438198
142PDGFRB0.44211911
143MINK10.43766980
144DAPK30.43290449
145CDK90.42568714
146TXK0.42295478
147PRKCE0.42269253
148PIM10.41850658
149NEK90.41280877
150MARK30.40945397
151PRKCZ0.40776233
152ICK0.40152639
153PRKACB0.39454361
154SCYL20.38490864
155TYRO30.38261398

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.63745507
2Cardiac muscle contraction_Homo sapiens_hsa042602.54454245
3Dilated cardiomyopathy_Homo sapiens_hsa054142.51604492
4B cell receptor signaling pathway_Homo sapiens_hsa046622.35513339
5Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.28138367
6Toll-like receptor signaling pathway_Homo sapiens_hsa046202.23635539
7Acute myeloid leukemia_Homo sapiens_hsa052212.08794266
8Fatty acid degradation_Homo sapiens_hsa000711.93877507
9Legionellosis_Homo sapiens_hsa051341.83828337
10Dorso-ventral axis formation_Homo sapiens_hsa043201.80521270
11Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.80496691
12Measles_Homo sapiens_hsa051621.79382905
13Malaria_Homo sapiens_hsa051441.79057023
14Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.74940083
15Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.71909371
16RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.68048857
17Other glycan degradation_Homo sapiens_hsa005111.65872733
18Influenza A_Homo sapiens_hsa051641.64045889
19Toxoplasmosis_Homo sapiens_hsa051451.62952899
20Allograft rejection_Homo sapiens_hsa053301.62221877
21NOD-like receptor signaling pathway_Homo sapiens_hsa046211.57849532
22Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.56626286
23Jak-STAT signaling pathway_Homo sapiens_hsa046301.53980877
24Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.52165107
25Fatty acid metabolism_Homo sapiens_hsa012121.52058240
26Non-small cell lung cancer_Homo sapiens_hsa052231.51366951
27Type II diabetes mellitus_Homo sapiens_hsa049301.48342264
28Hepatitis C_Homo sapiens_hsa051601.47845289
29Viral myocarditis_Homo sapiens_hsa054161.45092658
30African trypanosomiasis_Homo sapiens_hsa051431.44114276
31TNF signaling pathway_Homo sapiens_hsa046681.43655287
32Propanoate metabolism_Homo sapiens_hsa006401.43250257
33Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.39476599
34Adipocytokine signaling pathway_Homo sapiens_hsa049201.38818206
35T cell receptor signaling pathway_Homo sapiens_hsa046601.38440923
36Alzheimers disease_Homo sapiens_hsa050101.36581491
37cGMP-PKG signaling pathway_Homo sapiens_hsa040221.34737287
38NF-kappa B signaling pathway_Homo sapiens_hsa040641.34583947
392-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.32053122
40Hepatitis B_Homo sapiens_hsa051611.30815344
41Hematopoietic cell lineage_Homo sapiens_hsa046401.29539733
42Chronic myeloid leukemia_Homo sapiens_hsa052201.26987272
43GnRH signaling pathway_Homo sapiens_hsa049121.26467469
44* Insulin resistance_Homo sapiens_hsa049311.26226370
45Ovarian steroidogenesis_Homo sapiens_hsa049131.24603593
46Parkinsons disease_Homo sapiens_hsa050121.23708669
47Long-term potentiation_Homo sapiens_hsa047201.23118614
48Renin secretion_Homo sapiens_hsa049241.21018990
49Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.17713028
50Glucagon signaling pathway_Homo sapiens_hsa049221.16807834
51Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.15937742
52Oxytocin signaling pathway_Homo sapiens_hsa049211.15840780
53Olfactory transduction_Homo sapiens_hsa047401.15739333
54Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.15085363
55Herpes simplex infection_Homo sapiens_hsa051681.13492312
56* Insulin signaling pathway_Homo sapiens_hsa049101.12887061
57Oxidative phosphorylation_Homo sapiens_hsa001901.12784319
58Salivary secretion_Homo sapiens_hsa049701.12518886
59Leishmaniasis_Homo sapiens_hsa051401.10614056
60Vascular smooth muscle contraction_Homo sapiens_hsa042701.09042175
61Estrogen signaling pathway_Homo sapiens_hsa049151.08650118
62Circadian entrainment_Homo sapiens_hsa047131.08069749
63VEGF signaling pathway_Homo sapiens_hsa043701.06547729
64cAMP signaling pathway_Homo sapiens_hsa040241.05875714
65Fatty acid biosynthesis_Homo sapiens_hsa000611.04815913
66Leukocyte transendothelial migration_Homo sapiens_hsa046701.01021243
67Platelet activation_Homo sapiens_hsa046111.00153892
68Gastric acid secretion_Homo sapiens_hsa049710.99596145
69Autoimmune thyroid disease_Homo sapiens_hsa053200.98836231
70PPAR signaling pathway_Homo sapiens_hsa033200.98012971
71Apoptosis_Homo sapiens_hsa042100.97697656
72FoxO signaling pathway_Homo sapiens_hsa040680.93916158
73Graft-versus-host disease_Homo sapiens_hsa053320.93631890
74Aldosterone synthesis and secretion_Homo sapiens_hsa049250.93286069
75Phagosome_Homo sapiens_hsa041450.93035277
76Phospholipase D signaling pathway_Homo sapiens_hsa040720.92766644
77Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.89413124
78ErbB signaling pathway_Homo sapiens_hsa040120.88574951
79Focal adhesion_Homo sapiens_hsa045100.87897543
80Insulin secretion_Homo sapiens_hsa049110.87797681
81Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.87375872
82Starch and sucrose metabolism_Homo sapiens_hsa005000.86972608
83Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.86839543
84Glycosaminoglycan degradation_Homo sapiens_hsa005310.86585527
85Glioma_Homo sapiens_hsa052140.86234741
86Type I diabetes mellitus_Homo sapiens_hsa049400.86224146
87Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.85924353
88Cholinergic synapse_Homo sapiens_hsa047250.84828458
89Gap junction_Homo sapiens_hsa045400.83886844
90Carbon metabolism_Homo sapiens_hsa012000.83086997
91Notch signaling pathway_Homo sapiens_hsa043300.82883305
92Lysosome_Homo sapiens_hsa041420.82457674
93Neurotrophin signaling pathway_Homo sapiens_hsa047220.82116154
94Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.81524008
95Glutamatergic synapse_Homo sapiens_hsa047240.81084337
96Morphine addiction_Homo sapiens_hsa050320.80557337
97Pancreatic cancer_Homo sapiens_hsa052120.79707465
98Calcium signaling pathway_Homo sapiens_hsa040200.78987443
99Primary immunodeficiency_Homo sapiens_hsa053400.78645641
100Asthma_Homo sapiens_hsa053100.77885344
101Circadian rhythm_Homo sapiens_hsa047100.77692661
102Thyroid hormone signaling pathway_Homo sapiens_hsa049190.77448975
103Endocytosis_Homo sapiens_hsa041440.77294322
104Carbohydrate digestion and absorption_Homo sapiens_hsa049730.77121507
105Phosphatidylinositol signaling system_Homo sapiens_hsa040700.77116673
106Salmonella infection_Homo sapiens_hsa051320.76547976
107Renal cell carcinoma_Homo sapiens_hsa052110.76210584
108Prolactin signaling pathway_Homo sapiens_hsa049170.75730329
109Osteoclast differentiation_Homo sapiens_hsa043800.75707564
110Longevity regulating pathway - mammal_Homo sapiens_hsa042110.75136445
111Intestinal immune network for IgA production_Homo sapiens_hsa046720.74167115
112Regulation of actin cytoskeleton_Homo sapiens_hsa048100.74130438
113Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.74113554
114Prostate cancer_Homo sapiens_hsa052150.73959664
115Viral carcinogenesis_Homo sapiens_hsa052030.73246579
116Huntingtons disease_Homo sapiens_hsa050160.73106281
117Shigellosis_Homo sapiens_hsa051310.71801843
118Inositol phosphate metabolism_Homo sapiens_hsa005620.71512516
119Pyruvate metabolism_Homo sapiens_hsa006200.71083812
120Proteoglycans in cancer_Homo sapiens_hsa052050.70991311
121Tuberculosis_Homo sapiens_hsa051520.70131617
122HIF-1 signaling pathway_Homo sapiens_hsa040660.68729335
123Rap1 signaling pathway_Homo sapiens_hsa040150.68076071
124Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.67593490
125Antigen processing and presentation_Homo sapiens_hsa046120.67161453
126Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.66931210
127Small cell lung cancer_Homo sapiens_hsa052220.66544830
128Long-term depression_Homo sapiens_hsa047300.65739653
129AMPK signaling pathway_Homo sapiens_hsa041520.65118030
130Staphylococcus aureus infection_Homo sapiens_hsa051500.64277807
131Amoebiasis_Homo sapiens_hsa051460.63746915
132HTLV-I infection_Homo sapiens_hsa051660.63432250
133Rheumatoid arthritis_Homo sapiens_hsa053230.63204909
134AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.62670000
135Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.62384555
136Cocaine addiction_Homo sapiens_hsa050300.61718267
137Serotonergic synapse_Homo sapiens_hsa047260.61455639
138Dopaminergic synapse_Homo sapiens_hsa047280.59598496
139Chemokine signaling pathway_Homo sapiens_hsa040620.59520901
140Sphingolipid signaling pathway_Homo sapiens_hsa040710.59499233
141Adherens junction_Homo sapiens_hsa045200.56920825
142mTOR signaling pathway_Homo sapiens_hsa041500.56812744
143MAPK signaling pathway_Homo sapiens_hsa040100.56559376
144Thyroid cancer_Homo sapiens_hsa052160.56368884
145Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.55712457
146Colorectal cancer_Homo sapiens_hsa052100.55507279
147Bladder cancer_Homo sapiens_hsa052190.55483612
148Choline metabolism in cancer_Homo sapiens_hsa052310.54873059
149Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.54723836
150Ras signaling pathway_Homo sapiens_hsa040140.53853133
151Epstein-Barr virus infection_Homo sapiens_hsa051690.53164455
152Central carbon metabolism in cancer_Homo sapiens_hsa052300.52281464
153Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.52218140
154Pertussis_Homo sapiens_hsa051330.52034012
155Amphetamine addiction_Homo sapiens_hsa050310.51991994
156Endometrial cancer_Homo sapiens_hsa052130.49974584
157SNARE interactions in vesicular transport_Homo sapiens_hsa041300.44685141

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