PPP1R3E

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)7.05143516
2regulation of regulatory T cell differentiation (GO:0045589)5.75495876
3regulation of gamma-delta T cell differentiation (GO:0045586)5.71605889
4regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)5.40192244
5regulation of gamma-delta T cell activation (GO:0046643)5.18511867
6synaptic vesicle maturation (GO:0016188)4.73182220
7positive regulation of humoral immune response (GO:0002922)4.49061843
8negative regulation of protein oligomerization (GO:0032460)4.34549127
9positive regulation of CREB transcription factor activity (GO:0032793)4.30846420
10synaptic vesicle exocytosis (GO:0016079)3.97341531
11negative regulation of erythrocyte differentiation (GO:0045647)3.95272242
12positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.90773588
13membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.85206073
14negative regulation of nitric oxide biosynthetic process (GO:0045019)3.85004451
15myeloid dendritic cell activation (GO:0001773)3.83959685
16regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.82103084
17regulation of protein homooligomerization (GO:0032462)3.79875735
18T cell homeostasis (GO:0043029)3.77049390
19neurotransmitter secretion (GO:0007269)3.72938720
20synaptic vesicle docking involved in exocytosis (GO:0016081)3.68443308
21pericardium development (GO:0060039)3.64158744
22glutamate secretion (GO:0014047)3.62833326
23protein localization to cilium (GO:0061512)3.61936281
24antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.61763069
25antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.61763069
26myeloid dendritic cell differentiation (GO:0043011)3.49584701
27antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.48887148
28coronary vasculature morphogenesis (GO:0060977)3.47285675
29regulation of glutamate receptor signaling pathway (GO:1900449)3.44484799
30antigen processing and presentation via MHC class Ib (GO:0002475)3.42854972
31CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.41263858
32positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.39344187
33gamma-aminobutyric acid transport (GO:0015812)3.33305186
34regulation of short-term neuronal synaptic plasticity (GO:0048172)3.31883452
35production of molecular mediator involved in inflammatory response (GO:0002532)3.30357414
36lipopolysaccharide biosynthetic process (GO:0009103)3.29801470
37regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)3.27464992
38positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)3.27464992
39response to type I interferon (GO:0034340)3.24991434
40positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.24591821
41type I interferon signaling pathway (GO:0060337)3.22141575
42cellular response to type I interferon (GO:0071357)3.22141575
43cellular extravasation (GO:0045123)3.21873309
44positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.21809827
45positive regulation of natural killer cell mediated immunity (GO:0002717)3.21809827
46regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.20181839
47cellular potassium ion homeostasis (GO:0030007)3.18571393
48positive regulation of immunoglobulin mediated immune response (GO:0002891)3.17468417
49positive regulation of B cell mediated immunity (GO:0002714)3.17468417
50proline transport (GO:0015824)3.17325603
51antigen processing and presentation of endogenous antigen (GO:0019883)3.11610897
52regulation of natural killer cell mediated immunity (GO:0002715)3.11037378
53regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.11037378
54positive regulation of Rap GTPase activity (GO:0032854)3.09266187
55regulation of B cell receptor signaling pathway (GO:0050855)3.09100662
56regulation of synaptic vesicle exocytosis (GO:2000300)3.08970325
57histone H3-K4 trimethylation (GO:0080182)3.08252748
58cerebellar Purkinje cell differentiation (GO:0021702)3.08205095
59defense response to protozoan (GO:0042832)3.06092684
60axon ensheathment in central nervous system (GO:0032291)3.05601143
61central nervous system myelination (GO:0022010)3.05601143
62regulation of hypersensitivity (GO:0002883)3.05227527
63response to protozoan (GO:0001562)3.04901931
64negative regulation of cell killing (GO:0031342)3.03103753
65negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.03103753
66positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.02722732
67ionotropic glutamate receptor signaling pathway (GO:0035235)3.00825973
68cerebellar granule cell differentiation (GO:0021707)3.00069001
69neuromuscular process controlling posture (GO:0050884)2.97916347
70positive regulation of synapse maturation (GO:0090129)2.95115017
71synaptic transmission, glutamatergic (GO:0035249)2.94474787
72neurotransmitter transport (GO:0006836)2.94409182
73membrane depolarization during action potential (GO:0086010)2.91250639
74positive regulation of dendritic spine morphogenesis (GO:0061003)2.91142200
75toxin transport (GO:1901998)2.86514446
76cellular ketone body metabolic process (GO:0046950)2.85933995
77regulation of ARF protein signal transduction (GO:0032012)2.85924581
78regulation of neurotransmitter levels (GO:0001505)2.85904680
79positive regulation of membrane potential (GO:0045838)2.85480976
80respiratory burst (GO:0045730)2.85438481
81lipopolysaccharide metabolic process (GO:0008653)2.84124750
82potassium ion import (GO:0010107)2.81978737
83positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.78682682
84cellular response to zinc ion (GO:0071294)2.78033552
85regulation of synaptic vesicle transport (GO:1902803)2.77179205
86neuron-neuron synaptic transmission (GO:0007270)2.76017808
87mast cell activation (GO:0045576)2.75209662
88negative regulation of lipid catabolic process (GO:0050995)2.75136989
89neuronal action potential propagation (GO:0019227)2.73582713
90interferon-gamma-mediated signaling pathway (GO:0060333)2.72441188
91positive regulation of dendritic spine development (GO:0060999)2.69811440
92potassium ion homeostasis (GO:0055075)2.69369640
93JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.68524588
94regulation of Rap GTPase activity (GO:0032317)2.68220744
95leukocyte aggregation (GO:0070486)2.66840601
96negative regulation of phagocytosis (GO:0050765)2.66653266
97regulation of MHC class I biosynthetic process (GO:0045343)2.66206818
98negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.65112857
99calcium ion-dependent exocytosis (GO:0017156)2.63768283
100glutamate receptor signaling pathway (GO:0007215)2.62815529
101negative T cell selection (GO:0043383)2.62755269
102regulation of ARF GTPase activity (GO:0032312)2.62368565
103lymphocyte homeostasis (GO:0002260)2.62255662
104regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.60925933
105regulation of synapse maturation (GO:0090128)2.60713224
106interferon-gamma production (GO:0032609)2.59231481
107positive regulation of histone deacetylation (GO:0031065)2.58972897
108regulation of protein homodimerization activity (GO:0043496)2.58089093
109megakaryocyte development (GO:0035855)2.56623238
110negative thymic T cell selection (GO:0045060)2.56393217
111auditory receptor cell differentiation (GO:0042491)2.55334427
112natural killer cell activation involved in immune response (GO:0002323)2.55304568
113definitive hemopoiesis (GO:0060216)2.54817723
114regulation of T cell receptor signaling pathway (GO:0050856)2.51642915
115activated T cell proliferation (GO:0050798)2.51564808
116nephron tubule morphogenesis (GO:0072078)2.51286393
117nephron epithelium morphogenesis (GO:0072088)2.51286393
118establishment of protein localization to Golgi (GO:0072600)2.50377605
119brain morphogenesis (GO:0048854)2.49330564
120axoneme assembly (GO:0035082)2.49178033
121nerve growth factor signaling pathway (GO:0038180)2.48900617
122regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.48374490
123detection of light stimulus involved in visual perception (GO:0050908)2.48366459
124detection of light stimulus involved in sensory perception (GO:0050962)2.48366459
125cell differentiation in hindbrain (GO:0021533)2.47943574
126B cell receptor signaling pathway (GO:0050853)2.47714946
127T cell lineage commitment (GO:0002360)2.47098193
128positive thymic T cell selection (GO:0045059)2.46855715
129negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.46518409
130regulation of RNA export from nucleus (GO:0046831)2.46132074
131ketone body metabolic process (GO:1902224)2.45880746
132alanine transport (GO:0032328)2.45432739
133chemosensory behavior (GO:0007635)2.44472914
134positive regulation of isotype switching (GO:0045830)2.44354330
135positive regulation of natural killer cell differentiation (GO:0032825)2.44204747
136positive regulation of cytokine-mediated signaling pathway (GO:0001961)2.43287765
137neurotransmitter-gated ion channel clustering (GO:0072578)2.42915198
138positive regulation of granulocyte differentiation (GO:0030854)2.42657605
139regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.42624555
140actin filament polymerization (GO:0030041)2.42579703
141positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.42109106
142regulation of nuclear cell cycle DNA replication (GO:0033262)2.41966118
143negative regulation of synaptic transmission, GABAergic (GO:0032229)2.40790390
144positive regulation of DNA recombination (GO:0045911)2.40457587
145negative regulation of monooxygenase activity (GO:0032769)2.40383579
146neuromuscular synaptic transmission (GO:0007274)2.40359803
147regulation of RIG-I signaling pathway (GO:0039535)2.40163381
148response to pheromone (GO:0019236)2.39467491
149dendritic cell differentiation (GO:0097028)2.39199987
150phospholipid dephosphorylation (GO:0046839)2.39129665
151urinary tract smooth muscle contraction (GO:0014848)2.38780855
152positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.38749612
153positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.38476635
154regulation of immunoglobulin mediated immune response (GO:0002889)2.38292604
155leukocyte homeostasis (GO:0001776)2.37691219
156regulation of B cell mediated immunity (GO:0002712)2.37586677
157detection of calcium ion (GO:0005513)2.37258059
158regulation of leukocyte mediated cytotoxicity (GO:0001910)2.36872675
159gamma-aminobutyric acid signaling pathway (GO:0007214)2.36831927
160negative regulation of T cell receptor signaling pathway (GO:0050860)2.36156492
161histone H3-K9 demethylation (GO:0033169)2.35929548
162dendritic spine morphogenesis (GO:0060997)2.35379891
163regulation of interleukin-12 biosynthetic process (GO:0045075)2.34063005
164negative regulation of cytosolic calcium ion concentration (GO:0051481)2.33620719
165regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.33421896
166N-acetylneuraminate metabolic process (GO:0006054)2.33210549
167G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.33000284
168regulation of neurotransmitter secretion (GO:0046928)2.32723749
169glomerular filtration (GO:0003094)2.32516498
170protein targeting to Golgi (GO:0000042)2.32385195
171regulation of neuronal synaptic plasticity (GO:0048168)2.32355151
172macroautophagy (GO:0016236)2.32222382
173response to interleukin-15 (GO:0070672)2.32197318
174adult walking behavior (GO:0007628)2.31455728
175regulation of synapse structural plasticity (GO:0051823)2.30157152
176cellular potassium ion transport (GO:0071804)2.28056686
177potassium ion transmembrane transport (GO:0071805)2.28056686
178phosphatidylethanolamine biosynthetic process (GO:0006646)2.27871399
179regulation of synaptic transmission, dopaminergic (GO:0032225)2.27503890
180RNA destabilization (GO:0050779)2.27051247
181positive regulation of Rab GTPase activity (GO:0032851)2.26464648
182regulation of Rab GTPase activity (GO:0032313)2.26464648
183negative regulation of gluconeogenesis (GO:0045721)2.26321125
184regulation of dendritic spine morphogenesis (GO:0061001)2.25409930
185inositol phosphate catabolic process (GO:0071545)2.25085094
186regulation of long-term neuronal synaptic plasticity (GO:0048169)2.24929553
187L-amino acid import (GO:0043092)2.24105210
188startle response (GO:0001964)2.23410454
189sperm motility (GO:0030317)2.23262773
190phosphatidylinositol phosphorylation (GO:0046854)2.22771240
191retrograde transport, vesicle recycling within Golgi (GO:0000301)2.22597696

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human4.26989159
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.98602612
3IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.41168013
4IRF8_22096565_ChIP-ChIP_GC-B_Human3.38895994
5IRF8_21731497_ChIP-ChIP_J774_Mouse3.27485922
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.08155265
7MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.02936085
8BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.61907488
9IRF8_27001747_Chip-Seq_BMDM_Mouse2.35905495
10IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.30916914
11* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.30569007
12SCL_19346495_ChIP-Seq_HPC-7_Human2.20370138
13RUNX_20019798_ChIP-Seq_JUKART_Human2.18529744
14REST_18959480_ChIP-ChIP_MESCs_Mouse2.15222308
15VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.13864999
16STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.13541027
17NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.12969449
18NOTCH1_21737748_ChIP-Seq_TLL_Human2.08748808
19* RARB_27405468_Chip-Seq_BRAIN_Mouse2.06340287
20MYB_21317192_ChIP-Seq_ERMYB_Mouse1.97724084
21EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.96912030
22FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.92185715
23EGR1_19374776_ChIP-ChIP_THP-1_Human1.89197925
24ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.86182497
25THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.82908659
26VDR_24763502_ChIP-Seq_THP-1_Human1.78960922
27Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.77808982
28GBX2_23144817_ChIP-Seq_PC3_Human1.77067697
29GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.76509424
30SPI1_23127762_ChIP-Seq_K562_Human1.73664427
31* TCF7_22412390_ChIP-Seq_EML_Mouse1.72922707
32RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.72307667
33VDR_21846776_ChIP-Seq_THP-1_Human1.70236166
34STAT4_19710469_ChIP-ChIP_TH1__Mouse1.69521581
35RUNX1_22412390_ChIP-Seq_EML_Mouse1.66972049
36SUZ12_27294783_Chip-Seq_ESCs_Mouse1.63932212
37GATA3_27048872_Chip-Seq_THYMUS_Human1.60162103
38CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.58728055
39GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.55740518
40MYB_26560356_Chip-Seq_TH2_Human1.55166907
41LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.53682356
42PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.52916505
43MYC_22102868_ChIP-Seq_BL_Human1.52411798
44JARID2_20075857_ChIP-Seq_MESCs_Mouse1.49576430
45IKZF1_21737484_ChIP-ChIP_HCT116_Human1.41604374
46SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.40333605
47NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.39923315
48NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.36607633
49GATA1_19941827_ChIP-Seq_MEL_Mouse1.35547562
50UTX_26944678_Chip-Seq_JUKART_Human1.32981215
51KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.31047310
52MAF_26560356_Chip-Seq_TH1_Human1.30854609
53SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.28470532
54GATA2_21666600_ChIP-Seq_HMVEC_Human1.28368266
55GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.28267680
56DNAJC2_21179169_ChIP-ChIP_NT2_Human1.26713727
57GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.25206835
58* MYB_26560356_Chip-Seq_TH1_Human1.24980423
59SMAD_19615063_ChIP-ChIP_OVARY_Human1.24791282
60GATA2_19941826_ChIP-Seq_K562_Human1.24480003
61SPI1_23547873_ChIP-Seq_NB4_Human1.24238688
62* KDM2B_26808549_Chip-Seq_JURKAT_Human1.23955020
63GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.23814119
64LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.23623278
65* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.22810472
66* KDM2B_26808549_Chip-Seq_DND41_Human1.22632097
67DROSHA_22980978_ChIP-Seq_HELA_Human1.21478817
68EZH2_27304074_Chip-Seq_ESCs_Mouse1.20711795
69P68_20966046_ChIP-Seq_HELA_Human1.20086941
70MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.20064126
71* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.19268504
72RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.19157768
73RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.18663965
74* MAF_26560356_Chip-Seq_TH2_Human1.18531298
75SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.18517990
76BRD4_27068464_Chip-Seq_AML-cells_Mouse1.18447467
77VDR_24787735_ChIP-Seq_THP-1_Human1.15014464
78EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.14413551
79EGR1_19032775_ChIP-ChIP_M12_Human1.13338589
80ETV2_25802403_ChIP-Seq_MESCs_Mouse1.12643138
81TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11182733
82POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.11182733
83MTF2_20144788_ChIP-Seq_MESCs_Mouse1.10796011
84SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.10101468
85OCT4_19829295_ChIP-Seq_ESCs_Human1.09672196
86PIAS1_25552417_ChIP-Seq_VCAP_Human1.09210009
87* ELF1_20517297_ChIP-Seq_JURKAT_Human1.08859767
88PU_27001747_Chip-Seq_BMDM_Mouse1.08739897
89CTCF_27219007_Chip-Seq_Bcells_Human1.08633333
90CTBP2_25329375_ChIP-Seq_LNCAP_Human1.07509280
91AR_21572438_ChIP-Seq_LNCaP_Human1.06164290
92SMC4_20622854_ChIP-Seq_HELA_Human1.05597961
93OCT4_20526341_ChIP-Seq_ESCs_Human1.05487852
94RNF2_18974828_ChIP-Seq_MESCs_Mouse1.05469234
95EZH2_18974828_ChIP-Seq_MESCs_Mouse1.05469234
96SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05202232
97ZNF274_21170338_ChIP-Seq_K562_Hela1.04436592
98STAT3_23295773_ChIP-Seq_U87_Human1.02871947
99TCF4_23295773_ChIP-Seq_U87_Human1.01376115
100KDM2B_26808549_Chip-Seq_K562_Human1.01369148
101WT1_25993318_ChIP-Seq_PODOCYTE_Human1.01006413
102MYC_19829295_ChIP-Seq_ESCs_Human1.00798883
103REST_21632747_ChIP-Seq_MESCs_Mouse1.00380685
104LXR_22292898_ChIP-Seq_THP-1_Human0.99829444
105GATA3_26560356_Chip-Seq_TH2_Human0.98958498
106* ERA_21632823_ChIP-Seq_H3396_Human0.97437999
107SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.97007576
108PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.96913599
109GATA1_19941826_ChIP-Seq_K562_Human0.96907417
110CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.96518747
111RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.96518254
112NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.96498118
113SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.94742945
114VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.94667990
115* E2F1_20622854_ChIP-Seq_HELA_Human0.94132331
116EZH2_22144423_ChIP-Seq_EOC_Human0.94056889
117CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.93677055
118E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.93399087
119E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.93009915
120SMRT_27268052_Chip-Seq_Bcells_Human0.92802533
121BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.91057701
122* PHF8_20622854_ChIP-Seq_HELA_Human0.90854507
123PRDM14_20953172_ChIP-Seq_ESCs_Human0.90329915
124PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.89804361
125STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.88651189
126TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.88442008
127FOXA2_19822575_ChIP-Seq_HepG2_Human0.87672580
128SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.86669358
129TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.86585497
130MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.86545280
131RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.86511982
132SOX2_21211035_ChIP-Seq_LN229_Gbm0.86464920
133ARNT_22903824_ChIP-Seq_MCF-7_Human0.86416278
134* TAF2_19829295_ChIP-Seq_ESCs_Human0.86185221
135* MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.86083306
136ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.85965176
137AR_19668381_ChIP-Seq_PC3_Human0.85560084
138* RAC3_21632823_ChIP-Seq_H3396_Human0.84474628
139JARID2_20064375_ChIP-Seq_MESCs_Mouse0.83828012
140CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.83778362
141TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.82968976
142* CREB1_26743006_Chip-Seq_LNCaP_Human0.82695482
143BCAT_22108803_ChIP-Seq_LS180_Human0.82164320
144* BCL6_27268052_Chip-Seq_Bcells_Human0.82084415
145FOXA1_25552417_ChIP-Seq_VCAP_Human0.82036429
146BCOR_27268052_Chip-Seq_Bcells_Human0.81831082
147TRIM28_21343339_ChIP-Seq_HEK293_Human0.80818315
148PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.80339257
149NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.79717515
150GATA3_26560356_Chip-Seq_TH1_Human0.78910801
151TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.78753326
152GATA1_22383799_ChIP-Seq_G1ME_Mouse0.78196810
153RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.77128560
154SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.77096381
155SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.74552263
156EZH2_27294783_Chip-Seq_ESCs_Mouse0.71696886
157CDX2_19796622_ChIP-Seq_MESCs_Mouse0.71085752
158FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.70689982
159ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.69657217
160SMAD4_21799915_ChIP-Seq_A2780_Human0.69291105
161RNF2_27304074_Chip-Seq_ESCs_Mouse0.68714809

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003183_abnormal_peptide_metabolism3.17742846
2MP0003787_abnormal_imprinting2.73260024
3MP0005671_abnormal_response_to2.72275472
4MP0003122_maternal_imprinting2.59409346
5MP0003436_decreased_susceptibility_to2.53439197
6MP0001835_abnormal_antigen_presentation2.52278307
7MP0002064_seizures2.49213874
8MP0003880_abnormal_central_pattern2.44375987
9MP0003303_peritoneal_inflammation2.38456772
10MP0003866_abnormal_defecation2.36449717
11MP0002822_catalepsy2.33421731
12MP0005423_abnormal_somatic_nervous2.33377349
13MP0005174_abnormal_tail_pigmentation2.30882581
14MP0009745_abnormal_behavioral_response2.30716451
15MP0003300_gastrointestinal_ulcer2.23563392
16MP0003763_abnormal_thymus_physiology2.23349683
17MP0003879_abnormal_hair_cell2.23275652
18MP0002272_abnormal_nervous_system2.18456271
19MP0009046_muscle_twitch2.10363660
20MP0005670_abnormal_white_adipose2.07991970
21MP0004142_abnormal_muscle_tone2.03858960
22MP0005464_abnormal_platelet_physiology2.03696133
23MP0005000_abnormal_immune_tolerance1.92715221
24MP0004885_abnormal_endolymph1.91599942
25MP0008961_abnormal_basal_metabolism1.89587114
26MP0000569_abnormal_digit_pigmentation1.87889572
27MP0001790_abnormal_immune_system1.86584752
28MP0005387_immune_system_phenotype1.86584752
29MP0002419_abnormal_innate_immunity1.85954962
30MP0001986_abnormal_taste_sensitivity1.82862431
31MP0002572_abnormal_emotion/affect_behav1.79990292
32MP0008569_lethality_at_weaning1.78173346
33MP0005360_urolithiasis1.71482113
34MP0004742_abnormal_vestibular_system1.69078920
35MP0004859_abnormal_synaptic_plasticity1.67563287
36MP0002396_abnormal_hematopoietic_system1.67241702
37MP0006292_abnormal_olfactory_placode1.64901212
38MP0003172_abnormal_lysosome_physiology1.64285602
39MP0008877_abnormal_DNA_methylation1.63748754
40MP0001800_abnormal_humoral_immune1.63572679
41MP0000465_gastrointestinal_hemorrhage1.62398456
42MP0002148_abnormal_hypersensitivity_rea1.61887608
43MP0003195_calcinosis1.61028538
44MP0002420_abnormal_adaptive_immunity1.60589267
45MP0002723_abnormal_immune_serum1.59944079
46MP0001819_abnormal_immune_cell1.59028798
47MP0002452_abnormal_antigen_presenting1.58943222
48MP0010386_abnormal_urinary_bladder1.58598882
49MP0005025_abnormal_response_to1.56742680
50MP0001970_abnormal_pain_threshold1.55128497
51MP0002735_abnormal_chemical_nociception1.54535221
52MP0004808_abnormal_hematopoietic_stem1.54117004
53MP0005645_abnormal_hypothalamus_physiol1.54041164
54MP0003943_abnormal_hepatobiliary_system1.53427890
55MP0009780_abnormal_chondrocyte_physiolo1.53007629
56MP0010155_abnormal_intestine_physiology1.51037096
57MP0004147_increased_porphyrin_level1.50575213
58MP0004043_abnormal_pH_regulation1.50493834
59MP0005646_abnormal_pituitary_gland1.49577026
60MP0002398_abnormal_bone_marrow1.49486871
61MP0001873_stomach_inflammation1.49139693
62MP0005397_hematopoietic_system_phenotyp1.47309378
63MP0001545_abnormal_hematopoietic_system1.47309378
64MP0002733_abnormal_thermal_nociception1.46626594
65MP0005551_abnormal_eye_electrophysiolog1.45827818
66MP0001501_abnormal_sleep_pattern1.43739772
67MP0005410_abnormal_fertilization1.43587305
68MP0002067_abnormal_sensory_capabilities1.42824698
69MP0003633_abnormal_nervous_system1.41155471
70MP0003136_yellow_coat_color1.40496732
71MP0001502_abnormal_circadian_rhythm1.39604951
72MP0009333_abnormal_splenocyte_physiolog1.39019522
73MP0002166_altered_tumor_susceptibility1.38946366
74MP0001845_abnormal_inflammatory_respons1.38678600
75MP0002229_neurodegeneration1.34579865
76MP0000716_abnormal_immune_system1.34208242
77MP0002928_abnormal_bile_duct1.33226427
78MP0005535_abnormal_body_temperature1.31345237
79MP0005058_abnormal_lysosome_morphology1.30905579
80MP0002405_respiratory_system_inflammati1.29987806
81MP0003121_genomic_imprinting1.29795779
82MP0001188_hyperpigmentation1.29750115
83MP0002557_abnormal_social/conspecific_i1.27591717
84MP0002693_abnormal_pancreas_physiology1.26932349
85MP0005409_darkened_coat_color1.25530280
86MP0000490_abnormal_crypts_of1.24677845
87MP0000685_abnormal_immune_system1.24238004
88MP0003123_paternal_imprinting1.23339217
89MP0000703_abnormal_thymus_morphology1.23064297
90MP0002876_abnormal_thyroid_physiology1.21462728
91MP0003724_increased_susceptibility_to1.21054244
92MP0002006_tumorigenesis1.20728764
93MP0002837_dystrophic_cardiac_calcinosis1.19826870
94MP0004924_abnormal_behavior1.17010277
95MP0005386_behavior/neurological_phenoty1.17010277
96MP0003631_nervous_system_phenotype1.14898157
97MP0004270_analgesia1.13386007
98MP0002138_abnormal_hepatobiliary_system1.11847102
99MP0009785_altered_susceptibility_to1.11560911
100MP0010329_abnormal_lipoprotein_level1.11047289
101MP0001765_abnormal_ion_homeostasis1.10492009
102MP0002722_abnormal_immune_system1.09903773
103MP0003635_abnormal_synaptic_transmissio1.08417428
104MP0000013_abnormal_adipose_tissue1.07953667
105MP0002429_abnormal_blood_cell1.07873652
106MP0004811_abnormal_neuron_physiology1.07804339
107MP0006082_CNS_inflammation1.07596788
108MP0004381_abnormal_hair_follicle1.07246101
109MP0001533_abnormal_skeleton_physiology1.05391746
110MP0004858_abnormal_nervous_system1.04928896
111MP0000955_abnormal_spinal_cord1.04801448
112MP0002132_abnormal_respiratory_system1.03658103
113MP0001663_abnormal_digestive_system1.03437930
114MP0000015_abnormal_ear_pigmentation1.03311441
115MP0003329_amyloid_beta_deposits1.03219663
116MP0002066_abnormal_motor_capabilities/c1.03101309
117MP0005379_endocrine/exocrine_gland_phen1.02541761
118MP0005310_abnormal_salivary_gland1.02351589
119MP0004947_skin_inflammation1.02295893
120MP0001440_abnormal_grooming_behavior1.02069244
121MP0006276_abnormal_autonomic_nervous1.01982437
122MP0000604_amyloidosis1.01897422
123MP0002998_abnormal_bone_remodeling1.01186902
124MP0009764_decreased_sensitivity_to0.99441569
125MP0005220_abnormal_exocrine_pancreas0.99179925
126MP0000689_abnormal_spleen_morphology0.98903628
127MP0008469_abnormal_protein_level0.98095953
128MP0002139_abnormal_hepatobiliary_system0.96895755
129MP0002638_abnormal_pupillary_reflex0.96047796
130MP0005365_abnormal_bile_salt0.94482176
131MP0005085_abnormal_gallbladder_physiolo0.93606743
132MP0005377_hearing/vestibular/ear_phenot0.93258688
133MP0003878_abnormal_ear_physiology0.93258688
134MP0002882_abnormal_neuron_morphology0.92962120
135MP0001486_abnormal_startle_reflex0.92046571
136MP0009278_abnormal_bone_marrow0.92037593
137MP0004130_abnormal_muscle_cell0.91035963
138MP0003632_abnormal_nervous_system0.90844653
139MP0002909_abnormal_adrenal_gland0.90666484
140MP0001968_abnormal_touch/_nociception0.89983860
141MP0005448_abnormal_energy_balance0.89466005
142MP0004145_abnormal_muscle_electrophysio0.88852670
143MP0003690_abnormal_glial_cell0.88843086
144MP0002078_abnormal_glucose_homeostasis0.87133580
145MP0002063_abnormal_learning/memory/cond0.87107711
146MP0008995_early_reproductive_senescence0.86980735
147MP0008872_abnormal_physiological_respon0.86866282
148MP0005584_abnormal_enzyme/coenzyme_acti0.86767934
149MP0005334_abnormal_fat_pad0.86621723
150MP0000920_abnormal_myelination0.84997647
151MP0002095_abnormal_skin_pigmentation0.83888291
152MP0001485_abnormal_pinna_reflex0.83087638
153MP0005167_abnormal_blood-brain_barrier0.81962416
154MP0001944_abnormal_pancreas_morphology0.81517546
155MP0003075_altered_response_to0.80676251
156MP0003698_abnormal_male_reproductive0.80053066
157MP0002734_abnormal_mechanical_nocicepti0.79424069
158MP0005636_abnormal_mineral_homeostasis0.79381796
159MP0002970_abnormal_white_adipose0.78615918
160MP0001905_abnormal_dopamine_level0.78508799
161MP0001984_abnormal_olfaction0.77881936
162MP0003959_abnormal_lean_body0.77707464
163MP0005332_abnormal_amino_acid0.75079585
164MP0002163_abnormal_gland_morphology0.74783772
165MP0008874_decreased_physiological_sensi0.74636547
166MP0001963_abnormal_hearing_physiology0.74044916
167MP0002184_abnormal_innervation0.73675952

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of binocular vision (HP:0011514)3.99604755
2Diplopia (HP:0000651)3.99604755
3Febrile seizures (HP:0002373)3.84650391
4Epileptic encephalopathy (HP:0200134)3.82820728
5Eczematoid dermatitis (HP:0000976)3.68226526
6Tubular atrophy (HP:0000092)3.57333899
7Spontaneous hematomas (HP:0007420)3.56169222
8Genetic anticipation (HP:0003743)3.51871834
9Gastrointestinal infarctions (HP:0005244)3.35745463
10Increased circulating renin level (HP:0000848)3.25208190
11Papilledema (HP:0001085)3.14874824
12Abnormal eating behavior (HP:0100738)3.02086855
13Polyphagia (HP:0002591)3.00616801
14Abnormality of macrophages (HP:0004311)2.98065452
15Focal seizures (HP:0007359)2.95665336
16Panhypogammaglobulinemia (HP:0003139)2.95576259
17Vacuolated lymphocytes (HP:0001922)2.91958778
18Elevated erythrocyte sedimentation rate (HP:0003565)2.90539381
19Recurrent abscess formation (HP:0002722)2.83574558
20Gaze-evoked nystagmus (HP:0000640)2.83092765
21Agitation (HP:0000713)2.80493109
22Hyperventilation (HP:0002883)2.79131299
23Postural instability (HP:0002172)2.76227980
24Abnormality of the heme biosynthetic pathway (HP:0010472)2.75143040
25Disinhibition (HP:0000734)2.74827959
26Epileptiform EEG discharges (HP:0011182)2.74453923
27Mediastinal lymphadenopathy (HP:0100721)2.74351746
28Microcytic anemia (HP:0001935)2.72682336
29Abnormal platelet function (HP:0011869)2.72133860
30Impaired platelet aggregation (HP:0003540)2.72133860
31Obstructive sleep apnea (HP:0002870)2.71825641
32Focal motor seizures (HP:0011153)2.70840103
33EEG with generalized epileptiform discharges (HP:0011198)2.67683002
34Mutism (HP:0002300)2.66658418
35Urinary glycosaminoglycan excretion (HP:0003541)2.66233951
36Mucopolysacchariduria (HP:0008155)2.66233951
37Abnormality of the fingertips (HP:0001211)2.66225024
38Large for gestational age (HP:0001520)2.66016729
39Macroorchidism (HP:0000053)2.65714028
40Increased cerebral lipofuscin (HP:0011813)2.65500837
41Recurrent fungal infections (HP:0002841)2.64536298
42Recurrent gram-negative bacterial infections (HP:0005420)2.60504337
43Hemiparesis (HP:0001269)2.59495865
44Epistaxis (HP:0000421)2.59236552
45Hyperthyroidism (HP:0000836)2.58855545
46Chest pain (HP:0100749)2.56242715
47Prolonged bleeding time (HP:0003010)2.54855600
48Increased neuronal autofluorescent lipopigment (HP:0002074)2.53852365
49Hyperkalemia (HP:0002153)2.53698563
50Hypsarrhythmia (HP:0002521)2.52686003
51Recurrent bacterial skin infections (HP:0005406)2.49954191
52Gingival bleeding (HP:0000225)2.49529230
53Abnormality of DNA repair (HP:0003254)2.48069767
54Atonic seizures (HP:0010819)2.43165074
55Abnormality of the renal cortex (HP:0011035)2.42508298
56Hemiplegia (HP:0002301)2.41681328
57Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.36752814
58Ketosis (HP:0001946)2.32315775
59Dysostosis multiplex (HP:0000943)2.31960677
60Recurrent cutaneous fungal infections (HP:0011370)2.29984254
61Chronic mucocutaneous candidiasis (HP:0002728)2.29984254
62Sleep apnea (HP:0010535)2.28664702
63Abnormality of polysaccharide metabolism (HP:0011012)2.28301765
64Abnormality of glycosaminoglycan metabolism (HP:0004371)2.28301765
65Abnormality of mucopolysaccharide metabolism (HP:0011020)2.28301765
66Status epilepticus (HP:0002133)2.28250533
67Pustule (HP:0200039)2.26288518
68Absence seizures (HP:0002121)2.24824066
69Recurrent skin infections (HP:0001581)2.24103154
70Nephronophthisis (HP:0000090)2.21990343
71Generalized aminoaciduria (HP:0002909)2.21268280
72Abnormality of the common coagulation pathway (HP:0010990)2.21142313
73Vasculitis (HP:0002633)2.21006917
74Pulmonary embolism (HP:0002204)2.20893013
75Bile duct proliferation (HP:0001408)2.19188221
76Abnormal biliary tract physiology (HP:0012439)2.19188221
77Impaired smooth pursuit (HP:0007772)2.19049789
78Asymmetry of the thorax (HP:0001555)2.17710847
79Visual hallucinations (HP:0002367)2.17348926
80Chronic obstructive pulmonary disease (HP:0006510)2.17167563
81Obstructive lung disease (HP:0006536)2.17167563
82Action tremor (HP:0002345)2.16356922
83Hemoptysis (HP:0002105)2.16007847
84Ankle clonus (HP:0011448)2.15672481
85Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.14049768
86Congenital stationary night blindness (HP:0007642)2.13932353
87Dialeptic seizures (HP:0011146)2.13908174
88Urinary bladder sphincter dysfunction (HP:0002839)2.13762213
89Supranuclear gaze palsy (HP:0000605)2.12632219
90Absent speech (HP:0001344)2.12088781
91Widely spaced teeth (HP:0000687)2.11472610
92Recurrent viral infections (HP:0004429)2.11226749
93Thrombocytosis (HP:0001894)2.11103264
94Abnormality of the renal medulla (HP:0100957)2.11067001
95Hypomagnesemia (HP:0002917)2.10382895
96Inappropriate behavior (HP:0000719)2.10211802
97Hyperinsulinemic hypoglycemia (HP:0000825)2.09810615
98Decreased circulating renin level (HP:0003351)2.09149225
99Hematochezia (HP:0002573)2.07886114
100Meningitis (HP:0001287)2.06763971
101Pancreatic cysts (HP:0001737)2.06056514
102Severe visual impairment (HP:0001141)2.05848672
103Hepatocellular necrosis (HP:0001404)2.03762101
104Polydipsia (HP:0001959)2.03591064
105Abnormal drinking behavior (HP:0030082)2.03591064
106Broad-based gait (HP:0002136)2.01430876
107Ventricular fibrillation (HP:0001663)2.00196012
108Abnormal rod and cone electroretinograms (HP:0008323)1.99085397
109Cellulitis (HP:0100658)1.97727239
110Hypothermia (HP:0002045)1.97640725
111Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.97398737
112Truncal ataxia (HP:0002078)1.97227589
113Chronic otitis media (HP:0000389)1.96654114
114Abnormal hair whorl (HP:0010721)1.96423503
115Abnormality of the nasal mucosa (HP:0000433)1.96355455
116Truncal obesity (HP:0001956)1.95471320
117Conjunctival telangiectasia (HP:0000524)1.92519696
118Hypoglycemic coma (HP:0001325)1.92273043
119Truncus arteriosus (HP:0001660)1.92236614
120Spastic gait (HP:0002064)1.91684107
121Petechiae (HP:0000967)1.91290238
122Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.90684941
123Agammaglobulinemia (HP:0004432)1.90197168
124T lymphocytopenia (HP:0005403)1.89863105
125Abnormality of the prostate (HP:0008775)1.89690804
126Recurrent bronchitis (HP:0002837)1.88313395
127Abnormality of the corticospinal tract (HP:0002492)1.87937385
128Myokymia (HP:0002411)1.86959292
129Abnormality of renin-angiotensin system (HP:0000847)1.86448961
130Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.86240099
131Large eyes (HP:0001090)1.85568812
132Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.84591360
133Myocardial infarction (HP:0001658)1.83817306
134Autoimmune thrombocytopenia (HP:0001973)1.82648902
135Medial flaring of the eyebrow (HP:0010747)1.82519991
136Asymmetric septal hypertrophy (HP:0001670)1.81885871
137Increased serum ferritin (HP:0003281)1.81689574
138Abnormal EKG (HP:0003115)1.81059719
139Abnormality of potassium homeostasis (HP:0011042)1.79731579
140Arterial thrombosis (HP:0004420)1.78716806
141Abnormality of T cell number (HP:0011839)1.78040089
142Chronic hepatic failure (HP:0100626)1.77112381
143Thoracic kyphosis (HP:0002942)1.76790260
144Attenuation of retinal blood vessels (HP:0007843)1.76411304
145Prolonged QT interval (HP:0001657)1.75910675
146Colitis (HP:0002583)1.75853706
147Episodic fever (HP:0001954)1.75379300
148Abnormality of aromatic amino acid family metabolism (HP:0004338)1.75046410
149Spastic tetraparesis (HP:0001285)1.73778800
150Abnormality of saccadic eye movements (HP:0000570)1.73149123
151Spinal canal stenosis (HP:0003416)1.72397337
152Metabolic alkalosis (HP:0200114)1.72179570
153Degeneration of the lateral corticospinal tracts (HP:0002314)1.71345660
154Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.71345660
155Ketoacidosis (HP:0001993)1.71322418
156Myositis (HP:0100614)1.70525197
157Hepatic necrosis (HP:0002605)1.70190659
158Urethral obstruction (HP:0000796)1.70134066
159Sensorimotor neuropathy (HP:0007141)1.69652027
160Abnormal delayed hypersensitivity skin test (HP:0002963)1.69598152
161Hypoglycemic seizures (HP:0002173)1.69525988
162Hypochromic anemia (HP:0001931)1.69375032
163Cutaneous melanoma (HP:0012056)1.69163422
164Short nail (HP:0001799)1.66751023
165Cerebral hemorrhage (HP:0001342)1.66578772
166Progressive cerebellar ataxia (HP:0002073)1.66289361
167Abnormality of ocular smooth pursuit (HP:0000617)1.66265889
168Polyuria (HP:0000103)1.66085435
169Metaphyseal dysplasia (HP:0100255)1.66066454
170Bradykinesia (HP:0002067)1.65953577
171Aplastic anemia (HP:0001915)1.65629397
172Hypochromic microcytic anemia (HP:0004840)1.65585268
173Severe combined immunodeficiency (HP:0004430)1.65478301
174Volvulus (HP:0002580)1.65029599
175Generalized tonic-clonic seizures (HP:0002069)1.64753814
176Abnormality of magnesium homeostasis (HP:0004921)1.64601069
177Stomatitis (HP:0010280)1.64385816
178Morphological abnormality of the pyramidal tract (HP:0002062)1.63970624
179Hypokalemic alkalosis (HP:0001949)1.63886972
180Choreoathetosis (HP:0001266)1.62894058
181Tachypnea (HP:0002789)1.62191869
182Hypoplastic iliac wings (HP:0002866)1.61972502
183Stereotypic behavior (HP:0000733)1.60753392

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE14.02141908
2STK163.33750550
3MAP4K13.27614708
4PLK43.11305273
5TXK3.03297383
6TGFBR12.90492065
7FGFR42.88089273
8TAOK32.52427829
9DAPK22.47653823
10TGFBR22.41583199
11MAP2K72.35560136
12FGFR22.33473340
13NTRK22.10896915
14SCYL22.08427266
15JAK32.08098792
16MAP3K141.99810925
17TNK21.94946403
18MARK11.93395143
19PAK61.91346551
20KSR21.85668501
21EEF2K1.81011326
22SIK21.75438296
23FGFR31.74052409
24WNK41.63125144
25MAP3K131.56295855
26KIT1.49859669
27HIPK21.44968741
28ZAP701.42692369
29RIPK41.42662089
30MAPK121.40626550
31MAP2K61.39990788
32UHMK11.39262541
33ITK1.37391335
34PRPF4B1.35856080
35PASK1.34826056
36TRIB31.33929538
37IRAK41.32848208
38WNK11.32585176
39CAMKK21.32418799
40CAMK11.26949319
41SYK1.25681303
42EPHA41.24962267
43TEC1.21543808
44RET1.19913548
45TYRO31.16373419
46BMPR1B1.14708691
47CASK1.13488858
48BRD41.10256777
49SGK2231.09126479
50SGK4941.09126479
51TAOK11.08313854
52CDK31.07968879
53PRKD31.06670107
54PLK21.05601085
55SGK11.04712395
56PAK31.01491066
57PINK11.00132404
58RAF10.98242452
59SGK20.97343911
60CSNK1A1L0.97129879
61MAP4K20.95747309
62PDPK10.95504300
63CDK80.90491321
64ICK0.89813812
65INSRR0.89809908
66TBK10.89770980
67IRAK30.89452976
68CAMK1G0.88287275
69NTRK30.87957489
70HCK0.87515830
71PDGFRA0.85867437
72FES0.85773987
73PTK60.85065774
74STK380.84589067
75PKN20.83512658
76MAP3K70.82789168
77RPS6KA20.82310643
78STK110.82177989
79MAPK110.81805538
80NME20.81650698
81ALK0.79663826
82STK100.78915329
83MAPK70.78540366
84TYK20.78082088
85MAP3K10.77620601
86BTK0.76078290
87MAP3K90.75927741
88JAK20.75637576
89PRKD20.74357161
90CSNK1G30.74208026
91BLK0.73822559
92CSNK1G20.73262009
93CDK50.72678323
94PIK3CA0.72360662
95IRAK20.71784937
96LRRK20.71528281
97PRKCG0.70600584
98IKBKE0.69223999
99PRKAA20.68887874
100AKT30.68818045
101LCK0.68065857
102PRKAA10.67562804
103PRKCQ0.67453048
104JAK10.67173184
105GRK60.67140794
106MAP3K40.66490025
107PRKCH0.66304848
108PRKCZ0.66052546
109CAMKK10.65805773
110LYN0.63103017
111PHKG10.62381771
112PHKG20.62381771
113TRPM70.61689179
114TAOK20.60959653
115CDK90.60020240
116PDGFRB0.59544783
117ERBB30.59247297
118PTK2B0.59123647
119CSNK1G10.57694601
120CLK10.56091976
121SIK30.56086214
122ERN10.55702526
123CAMK40.55584339
124SIK10.54052014
125MAP3K20.53653673
126NLK0.52493270
127CDC42BPA0.52198558
128MAPK150.49288505
129YES10.48869837
130DYRK1A0.48478018
131SGK30.45342547
132ADRBK20.44792913
133PDK10.44075121
134CSK0.43227305
135IKBKB0.43184541
136KSR10.42731669
137MARK30.42483312
138RPS6KA30.41673843
139CHUK0.40864762
140FRK0.40421380
141MARK20.40165756
142RPS6KA40.39790000
143PKN10.37223917
144ACVR1B0.36273671
145MINK10.36222054
146MATK0.35059522
147MAP2K40.34814211
148PIK3CG0.30345951
149CAMK1D0.28853961
150MAPK130.28013549

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006043.08769177
2Nicotine addiction_Homo sapiens_hsa050332.50117059
3NF-kappa B signaling pathway_Homo sapiens_hsa040642.42537621
4Synaptic vesicle cycle_Homo sapiens_hsa047212.04282962
5Olfactory transduction_Homo sapiens_hsa047402.03706974
6Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.95663694
7Maturity onset diabetes of the young_Homo sapiens_hsa049501.93897983
8Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.91686143
9Leishmaniasis_Homo sapiens_hsa051401.90288171
10Osteoclast differentiation_Homo sapiens_hsa043801.80480453
11Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.77259361
12Toll-like receptor signaling pathway_Homo sapiens_hsa046201.76665614
13T cell receptor signaling pathway_Homo sapiens_hsa046601.70212922
14Amphetamine addiction_Homo sapiens_hsa050311.69053852
15N-Glycan biosynthesis_Homo sapiens_hsa005101.67779374
16Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.67432213
17B cell receptor signaling pathway_Homo sapiens_hsa046621.61240527
18Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.60169232
19NOD-like receptor signaling pathway_Homo sapiens_hsa046211.58625098
20Butanoate metabolism_Homo sapiens_hsa006501.53731125
21TNF signaling pathway_Homo sapiens_hsa046681.50641877
22Oxytocin signaling pathway_Homo sapiens_hsa049211.46318959
23Pertussis_Homo sapiens_hsa051331.44555735
24Hepatitis B_Homo sapiens_hsa051611.42738388
25Insulin secretion_Homo sapiens_hsa049111.41625579
26Intestinal immune network for IgA production_Homo sapiens_hsa046721.39668276
27Jak-STAT signaling pathway_Homo sapiens_hsa046301.39493201
28Autoimmune thyroid disease_Homo sapiens_hsa053201.38930723
29Prolactin signaling pathway_Homo sapiens_hsa049171.38050479
30Long-term depression_Homo sapiens_hsa047301.37748978
31Renin secretion_Homo sapiens_hsa049241.36456356
32Neurotrophin signaling pathway_Homo sapiens_hsa047221.35890709
33Tuberculosis_Homo sapiens_hsa051521.32411279
34Inositol phosphate metabolism_Homo sapiens_hsa005621.30739955
35Cocaine addiction_Homo sapiens_hsa050301.30249328
36Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.29000253
37Type II diabetes mellitus_Homo sapiens_hsa049301.28168448
38Measles_Homo sapiens_hsa051621.27874826
39Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.25811217
40Calcium signaling pathway_Homo sapiens_hsa040201.24889959
41Taste transduction_Homo sapiens_hsa047421.22612801
42Chemokine signaling pathway_Homo sapiens_hsa040621.21959385
43RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.21476155
44Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.19759390
45Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.19267609
46Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.18593836
47Cholinergic synapse_Homo sapiens_hsa047251.17620052
48Acute myeloid leukemia_Homo sapiens_hsa052211.17445701
49cAMP signaling pathway_Homo sapiens_hsa040241.16617352
50Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.16500465
51Serotonergic synapse_Homo sapiens_hsa047261.15996605
52Chronic myeloid leukemia_Homo sapiens_hsa052201.15957610
53AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.14229491
54Glycosaminoglycan degradation_Homo sapiens_hsa005311.11440467
55Primary immunodeficiency_Homo sapiens_hsa053401.11015071
56Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.10571970
57Toxoplasmosis_Homo sapiens_hsa051451.10396171
58Type I diabetes mellitus_Homo sapiens_hsa049401.09674166
59Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.09017304
60Circadian rhythm_Homo sapiens_hsa047101.07643358
61Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.07462983
62Staphylococcus aureus infection_Homo sapiens_hsa051501.07334269
63Glycerophospholipid metabolism_Homo sapiens_hsa005641.06812633
64* Insulin resistance_Homo sapiens_hsa049311.06536388
65Apoptosis_Homo sapiens_hsa042101.05317434
66Morphine addiction_Homo sapiens_hsa050321.03276555
67Viral myocarditis_Homo sapiens_hsa054161.03180023
68mTOR signaling pathway_Homo sapiens_hsa041501.02765326
69Carbohydrate digestion and absorption_Homo sapiens_hsa049731.00349148
70Sphingolipid signaling pathway_Homo sapiens_hsa040710.99091994
71Allograft rejection_Homo sapiens_hsa053300.97573560
72Vascular smooth muscle contraction_Homo sapiens_hsa042700.96873871
73Gastric acid secretion_Homo sapiens_hsa049710.96582930
74Glucagon signaling pathway_Homo sapiens_hsa049220.95127409
75Endometrial cancer_Homo sapiens_hsa052130.94856781
76Lysosome_Homo sapiens_hsa041420.93094172
77Non-small cell lung cancer_Homo sapiens_hsa052230.93080988
78Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.90819106
79Phospholipase D signaling pathway_Homo sapiens_hsa040720.90232632
80Ether lipid metabolism_Homo sapiens_hsa005650.87859668
81ErbB signaling pathway_Homo sapiens_hsa040120.83551231
82cGMP-PKG signaling pathway_Homo sapiens_hsa040220.83180555
83Platelet activation_Homo sapiens_hsa046110.82880540
84Hematopoietic cell lineage_Homo sapiens_hsa046400.81255869
85Asthma_Homo sapiens_hsa053100.79702388
86Aldosterone synthesis and secretion_Homo sapiens_hsa049250.79314797
87Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.79103988
88Glioma_Homo sapiens_hsa052140.78935081
89MAPK signaling pathway_Homo sapiens_hsa040100.78335051
90Estrogen signaling pathway_Homo sapiens_hsa049150.77756146
91Salivary secretion_Homo sapiens_hsa049700.74966731
92Colorectal cancer_Homo sapiens_hsa052100.74177892
93Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.74113384
94Pancreatic secretion_Homo sapiens_hsa049720.73678248
95Pancreatic cancer_Homo sapiens_hsa052120.73482011
96Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.72704233
97Bile secretion_Homo sapiens_hsa049760.71035661
98Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.70105585
99FoxO signaling pathway_Homo sapiens_hsa040680.69581136
100Prion diseases_Homo sapiens_hsa050200.69570375
101Caffeine metabolism_Homo sapiens_hsa002320.68133744
102Circadian entrainment_Homo sapiens_hsa047130.66995163
103Dopaminergic synapse_Homo sapiens_hsa047280.66805628
104Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.66688487
105Linoleic acid metabolism_Homo sapiens_hsa005910.66365166
106Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.66184319
107Vitamin B6 metabolism_Homo sapiens_hsa007500.65506809
108Antigen processing and presentation_Homo sapiens_hsa046120.65195723
109Collecting duct acid secretion_Homo sapiens_hsa049660.65127464
110SNARE interactions in vesicular transport_Homo sapiens_hsa041300.64818531
111ABC transporters_Homo sapiens_hsa020100.64555788
112Hepatitis C_Homo sapiens_hsa051600.64385285
113GABAergic synapse_Homo sapiens_hsa047270.64138756
114Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.63896874
115Regulation of autophagy_Homo sapiens_hsa041400.63097602
116Influenza A_Homo sapiens_hsa051640.61513380
117Ovarian steroidogenesis_Homo sapiens_hsa049130.60732154
118alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.60450057
119Nitrogen metabolism_Homo sapiens_hsa009100.60044218
120Glutamatergic synapse_Homo sapiens_hsa047240.59990886
121Long-term potentiation_Homo sapiens_hsa047200.59362066
122GnRH signaling pathway_Homo sapiens_hsa049120.59173423
123Phosphatidylinositol signaling system_Homo sapiens_hsa040700.59171927
124Longevity regulating pathway - mammal_Homo sapiens_hsa042110.58928905
125Thyroid hormone synthesis_Homo sapiens_hsa049180.58859614
126Shigellosis_Homo sapiens_hsa051310.57872173
127Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.57549145
128Sphingolipid metabolism_Homo sapiens_hsa006000.56885683
129Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.56374598
130Salmonella infection_Homo sapiens_hsa051320.56132512
131Adipocytokine signaling pathway_Homo sapiens_hsa049200.55650790
132* Insulin signaling pathway_Homo sapiens_hsa049100.53742496
133Choline metabolism in cancer_Homo sapiens_hsa052310.53235307
134Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.52256124
135Graft-versus-host disease_Homo sapiens_hsa053320.52176992
136Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.51907932
137Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.50929960
138Thyroid hormone signaling pathway_Homo sapiens_hsa049190.49985887
139Dorso-ventral axis formation_Homo sapiens_hsa043200.49978236
140VEGF signaling pathway_Homo sapiens_hsa043700.49773859
141Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.49450935
142Other glycan degradation_Homo sapiens_hsa005110.49325436
143Lysine degradation_Homo sapiens_hsa003100.47544375
144Gap junction_Homo sapiens_hsa045400.46374219
145AMPK signaling pathway_Homo sapiens_hsa041520.45302313

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