PPP1R3F

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that has been identified as one of several type-1 protein phosphatase (PP1) regulatory subunits. One or two of these subunits, together with the well-conserved catalytic subunit, can form the PP1 holoenzyme, where the regulatory subunit functions to regulate substrate specificity and/or targeting to a particular cellular compartment. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neuron cell-cell adhesion (GO:0007158)5.01006774
2regulation of short-term neuronal synaptic plasticity (GO:0048172)4.99822454
3positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.72735818
4regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.72407418
5vocalization behavior (GO:0071625)4.60073702
6regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)4.59809244
7synaptic vesicle exocytosis (GO:0016079)4.50743139
8positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.45771217
9synaptic vesicle maturation (GO:0016188)4.42303067
10locomotory exploration behavior (GO:0035641)4.40058793
11negative regulation of B cell mediated immunity (GO:0002713)4.39195627
12negative regulation of immunoglobulin mediated immune response (GO:0002890)4.39195627
13regulation of synaptic vesicle exocytosis (GO:2000300)4.38697269
14neuronal action potential propagation (GO:0019227)4.30111744
15protein localization to synapse (GO:0035418)4.28875220
16ionotropic glutamate receptor signaling pathway (GO:0035235)4.26174040
17sodium ion export (GO:0071436)4.24035945
18regulation of glutamate receptor signaling pathway (GO:1900449)4.17102096
19positive regulation of synaptic transmission, dopaminergic (GO:0032226)4.10217750
20positive regulation of synapse maturation (GO:0090129)4.08238711
21central nervous system myelination (GO:0022010)4.04652757
22axon ensheathment in central nervous system (GO:0032291)4.04652757
23glutamate secretion (GO:0014047)4.01007736
24regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.98518761
25presynaptic membrane assembly (GO:0097105)3.94332169
26positive regulation of synaptic transmission, GABAergic (GO:0032230)3.91674792
27exploration behavior (GO:0035640)3.86145667
28regulation of synaptic vesicle transport (GO:1902803)3.84748157
29cell communication by electrical coupling (GO:0010644)3.83416680
30neurotransmitter secretion (GO:0007269)3.80151342
31postsynaptic membrane organization (GO:0001941)3.79915492
32regulation of memory T cell differentiation (GO:0043380)3.79242504
33synaptic transmission, glutamatergic (GO:0035249)3.77819220
34presynaptic membrane organization (GO:0097090)3.74492378
35regulation of T-helper 2 cell differentiation (GO:0045628)3.71509234
36positive regulation of dendritic spine development (GO:0060999)3.69795179
37glutamate receptor signaling pathway (GO:0007215)3.68317965
38neuron-neuron synaptic transmission (GO:0007270)3.63803953
39regulation of voltage-gated calcium channel activity (GO:1901385)3.59646553
40potassium ion import (GO:0010107)3.57403477
41dendritic spine morphogenesis (GO:0060997)3.57067275
42gamma-aminobutyric acid signaling pathway (GO:0007214)3.50868841
43regulation of neuronal synaptic plasticity (GO:0048168)3.47201991
44potassium ion homeostasis (GO:0055075)3.47131927
45layer formation in cerebral cortex (GO:0021819)3.47084578
46regulation of long-term neuronal synaptic plasticity (GO:0048169)3.46841471
47negative regulation of synaptic transmission, GABAergic (GO:0032229)3.45710154
48long-term memory (GO:0007616)3.45418058
49transmission of nerve impulse (GO:0019226)3.44673877
50cerebellar Purkinje cell differentiation (GO:0021702)3.44277001
51regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.44050804
52negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.43426173
53negative regulation of T-helper cell differentiation (GO:0045623)3.43426173
54synaptic vesicle docking involved in exocytosis (GO:0016081)3.40560032
55regulation of synapse maturation (GO:0090128)3.39947673
56regulation of ARF protein signal transduction (GO:0032012)3.39332961
57regulation of cell communication by electrical coupling (GO:0010649)3.36289123
58neuron recognition (GO:0008038)3.35382923
59regulation of excitatory postsynaptic membrane potential (GO:0060079)3.35274884
60gamma-aminobutyric acid transport (GO:0015812)3.34334277
61regulation of postsynaptic membrane potential (GO:0060078)3.31912773
62synaptic vesicle endocytosis (GO:0048488)3.30219953
63positive regulation of membrane potential (GO:0045838)3.29950253
64neurotransmitter-gated ion channel clustering (GO:0072578)3.29188076
65sarcoplasmic reticulum calcium ion transport (GO:0070296)3.27377745
66establishment of mitochondrion localization (GO:0051654)3.26934013
67neurotransmitter transport (GO:0006836)3.26466316
68membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.25043692
69regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.24875976
70activation of protein kinase A activity (GO:0034199)3.24351050
71regulation of vesicle fusion (GO:0031338)3.22921952
72detection of calcium ion (GO:0005513)3.21133383
73membrane hyperpolarization (GO:0060081)3.20890011
74righting reflex (GO:0060013)3.19357749
75startle response (GO:0001964)3.18511417
76regulation of neurotransmitter secretion (GO:0046928)3.16815451
77glycine transport (GO:0015816)3.16138374
78cell differentiation in hindbrain (GO:0021533)3.15915352
79regulation of dendritic spine development (GO:0060998)3.13285251
80dendritic spine organization (GO:0097061)3.13145230
81adult walking behavior (GO:0007628)3.12737999
82cell communication involved in cardiac conduction (GO:0086065)3.10895196
83cell migration in hindbrain (GO:0021535)3.10893842
84auditory behavior (GO:0031223)3.10294333
85regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.08794172
86positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.08241745
87positive regulation of dendritic spine morphogenesis (GO:0061003)3.07946377
88regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.06710412
89regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.05341621
90regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.04960670
91negative regulation of type 2 immune response (GO:0002829)3.04570590
92positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.03546477
93regulation of respiratory system process (GO:0044065)3.02260578
94long-term synaptic potentiation (GO:0060291)3.00338129
95negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.99261239
96membrane depolarization (GO:0051899)2.98870331
97response to auditory stimulus (GO:0010996)2.97018988
98regulation of neurotransmitter transport (GO:0051588)2.96727782
99negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.95049099
100amino acid import (GO:0043090)2.95012679
101adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.94411974
102cerebral cortex radially oriented cell migration (GO:0021799)2.93191455
103negative regulation of dendrite morphogenesis (GO:0050774)2.91509239
104establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.91360005
105axonal fasciculation (GO:0007413)2.91155809
106regulation of synaptic transmission, GABAergic (GO:0032228)2.89571169
107neuromuscular synaptic transmission (GO:0007274)2.88301424
108regulation of neurotransmitter levels (GO:0001505)2.87901975
109positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.87496321
110neuromuscular process controlling posture (GO:0050884)2.86909823
111synapse assembly (GO:0007416)2.86623289
112regulation of synaptic plasticity (GO:0048167)2.84950017
113regulation of synaptic transmission, glutamatergic (GO:0051966)2.84949172
114L-amino acid import (GO:0043092)2.84667163
115regulation of respiratory gaseous exchange (GO:0043576)2.81666199
116membrane depolarization during action potential (GO:0086010)2.80593022
117neuronal ion channel clustering (GO:0045161)2.80571616
118regulation of timing of cell differentiation (GO:0048505)2.79534113
119prepulse inhibition (GO:0060134)2.78859265
120positive regulation of neurotransmitter secretion (GO:0001956)2.77837785
121proline transport (GO:0015824)2.75877932
122regulation of dendritic spine morphogenesis (GO:0061001)2.75187783
123regulation of synapse structural plasticity (GO:0051823)2.74943355
124neuromuscular process controlling balance (GO:0050885)2.74934120
125cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.72080254
126positive regulation of synapse assembly (GO:0051965)2.71528395
127synaptic transmission (GO:0007268)2.68250669
128positive regulation of neurotransmitter transport (GO:0051590)2.67881915
129G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.65922358
130cellular potassium ion homeostasis (GO:0030007)2.65560542
131learning (GO:0007612)2.65413048
132cerebellar granule cell differentiation (GO:0021707)2.64839250
133regulation of glutamate secretion (GO:0014048)2.64515921
134mechanosensory behavior (GO:0007638)2.63473580

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.29624032
2GBX2_23144817_ChIP-Seq_PC3_Human3.71938077
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.99283022
4JARID2_20064375_ChIP-Seq_MESCs_Mouse2.96119034
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.87305860
6SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.48924921
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.46203160
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.46203160
9REST_21632747_ChIP-Seq_MESCs_Mouse2.46201677
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.41209601
11MTF2_20144788_ChIP-Seq_MESCs_Mouse2.40177485
12SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.39573668
13EZH2_27304074_Chip-Seq_ESCs_Mouse2.39235377
14SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.38334397
15DROSHA_22980978_ChIP-Seq_HELA_Human2.37296563
16SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.33509706
17GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.31866682
18EED_16625203_ChIP-ChIP_MESCs_Mouse2.28396435
19EZH2_27294783_Chip-Seq_ESCs_Mouse2.27854082
20IKZF1_21737484_ChIP-ChIP_HCT116_Human2.19900943
21SUZ12_27294783_Chip-Seq_ESCs_Mouse2.19360888
22AR_21572438_ChIP-Seq_LNCaP_Human2.14957953
23THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.12548115
24RNF2_27304074_Chip-Seq_ESCs_Mouse2.05346427
25RARB_27405468_Chip-Seq_BRAIN_Mouse2.04224872
26RCOR2_21632747_ChIP-Seq_MESCs_Mouse2.00658217
27CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.99094405
28REST_18959480_ChIP-ChIP_MESCs_Mouse1.91838074
29ZFP57_27257070_Chip-Seq_ESCs_Mouse1.86458940
30IGF1R_20145208_ChIP-Seq_DFB_Human1.72455189
31ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.70103333
32NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.66197248
33SMAD4_21799915_ChIP-Seq_A2780_Human1.65875304
34CTBP2_25329375_ChIP-Seq_LNCAP_Human1.65175370
35BMI1_23680149_ChIP-Seq_NPCS_Mouse1.64917724
36ZFP281_18757296_ChIP-ChIP_E14_Mouse1.64553371
37KDM2B_26808549_Chip-Seq_K562_Human1.63215867
38DNAJC2_21179169_ChIP-ChIP_NT2_Human1.62782667
39TAF15_26573619_Chip-Seq_HEK293_Human1.57228348
40CTBP1_25329375_ChIP-Seq_LNCAP_Human1.56692896
41PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.53567877
42GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.53371433
43CTCF_27219007_Chip-Seq_Bcells_Human1.52707660
44SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.49367701
45P300_19829295_ChIP-Seq_ESCs_Human1.46835262
46* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.46467570
47CBX2_27304074_Chip-Seq_ESCs_Mouse1.44601189
48ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.43173840
49EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.41415249
50VDR_22108803_ChIP-Seq_LS180_Human1.39443668
51SMAD3_21741376_ChIP-Seq_EPCs_Human1.39041790
52CDX2_19796622_ChIP-Seq_MESCs_Mouse1.38747092
53PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.35894621
54RNF2_27304074_Chip-Seq_NSC_Mouse1.34690055
55PIAS1_25552417_ChIP-Seq_VCAP_Human1.32547708
56MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.31595248
57SMAD_19615063_ChIP-ChIP_OVARY_Human1.30957279
58TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.30878410
59P53_22127205_ChIP-Seq_FIBROBLAST_Human1.30870132
60RING1B_27294783_Chip-Seq_ESCs_Mouse1.28951338
61KDM2B_26808549_Chip-Seq_SUP-B15_Human1.25877831
62RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.25014163
63STAT3_23295773_ChIP-Seq_U87_Human1.24888391
64OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.22724804
65SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.22347808
66VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.22290483
67ZFP281_27345836_Chip-Seq_ESCs_Mouse1.21476598
68TOP2B_26459242_ChIP-Seq_MCF-7_Human1.21240143
69OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.19905341
70TP53_20018659_ChIP-ChIP_R1E_Mouse1.19539616
71TET1_21490601_ChIP-Seq_MESCs_Mouse1.17871690
72SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.17576305
73PCGF2_27294783_Chip-Seq_ESCs_Mouse1.17082915
74POU3F2_20337985_ChIP-ChIP_501MEL_Human1.16491864
75FLI1_27457419_Chip-Seq_LIVER_Mouse1.16212029
76ERG_21242973_ChIP-ChIP_JURKAT_Human1.15537934
77CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.15509327
78LXR_22292898_ChIP-Seq_THP-1_Human1.15426122
79* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.14530846
80AR_25329375_ChIP-Seq_VCAP_Human1.13429267
81NANOG_18555785_Chip-Seq_ESCs_Mouse1.12409844
82SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.11838101
83PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.11324584
84TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.11141584
85SOX2_21211035_ChIP-Seq_LN229_Gbm1.10009495
86NR3C1_23031785_ChIP-Seq_PC12_Mouse1.09488702
87TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.08933788
88RING1B_27294783_Chip-Seq_NPCs_Mouse1.07991308
89RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.07437402
90RUNX2_22187159_ChIP-Seq_PCA_Human1.05878360
91ARNT_22903824_ChIP-Seq_MCF-7_Human1.05371588
92TCF4_23295773_ChIP-Seq_U87_Human1.05322934
93SUZ12_27294783_Chip-Seq_NPCs_Mouse1.05284053
94AR_19668381_ChIP-Seq_PC3_Human1.04557503
95* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.04493762
96E2F1_18555785_Chip-Seq_ESCs_Mouse1.04440601
97TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.04070396
98WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.03760518
99AHR_22903824_ChIP-Seq_MCF-7_Human1.03690538
100TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03202905
101CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02663968
102CMYC_18555785_Chip-Seq_ESCs_Mouse1.01373141
103OCT4_19829295_ChIP-Seq_ESCs_Human1.01256592
104GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00557089
105NR3C1_21868756_ChIP-Seq_MCF10A_Human1.00555147
106SMC4_20622854_ChIP-Seq_HELA_Human1.00049626
107PRDM14_20953172_ChIP-Seq_ESCs_Human0.99634995
108UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.97772836
109EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.97431692
110P53_22387025_ChIP-Seq_ESCs_Mouse0.97355197
111KDM2B_26808549_Chip-Seq_DND41_Human0.97329978
112MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.96739482
113ER_23166858_ChIP-Seq_MCF-7_Human0.95509767
114YAP1_20516196_ChIP-Seq_MESCs_Mouse0.94794409
115JUN_21703547_ChIP-Seq_K562_Human0.93393667
116LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93291300
117TP53_18474530_ChIP-ChIP_U2OS_Human0.92606377
118STAT3_18555785_Chip-Seq_ESCs_Mouse0.92597302
119SUZ12_18555785_Chip-Seq_ESCs_Mouse0.92223666
120SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.92103591
121EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.91299904
122P300_18555785_Chip-Seq_ESCs_Mouse0.89854843
123WT1_25993318_ChIP-Seq_PODOCYTE_Human0.89738483
124SMAD3_21741376_ChIP-Seq_ESCs_Human0.89736311
125AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.88927060
126DPY_21335234_ChIP-Seq_ESCs_Mouse0.88068517
127SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.87868060
128FUS_26573619_Chip-Seq_HEK293_Human0.87850288
129SOX2_18555785_Chip-Seq_ESCs_Mouse0.87104622
130P68_20966046_ChIP-Seq_HELA_Human0.85723530
131ESR2_21235772_ChIP-Seq_MCF-7_Human0.84054521
132GATA1_26923725_Chip-Seq_HPCs_Mouse0.83823757
133ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.82582083
134MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.82153680
135* KDM2B_26808549_Chip-Seq_JURKAT_Human0.80725109
136SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.80591081
137* TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.80198546
138KLF4_19829295_ChIP-Seq_ESCs_Human0.79595000
139* CREB1_26743006_Chip-Seq_LNCaP_Human0.76871325
140TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.76731454
141SMAD4_21741376_ChIP-Seq_ESCs_Human0.75594685
142RUNX1_26923725_Chip-Seq_HPCs_Mouse0.74889195
143TP53_23651856_ChIP-Seq_MEFs_Mouse0.74685054
144MYC_27129775_Chip-Seq_CORNEA_Mouse0.71827773
145EP300_21415370_ChIP-Seq_HL-1_Mouse0.71501100

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.16138481
2MP0003880_abnormal_central_pattern5.07698345
3MP0003635_abnormal_synaptic_transmissio3.62756001
4MP0009745_abnormal_behavioral_response3.24033958
5MP0009046_muscle_twitch3.21244646
6MP0002064_seizures3.07464764
7MP0001968_abnormal_touch/_nociception3.05052029
8MP0004270_analgesia2.92848601
9MP0002063_abnormal_learning/memory/cond2.78114212
10MP0001486_abnormal_startle_reflex2.74453401
11MP0005423_abnormal_somatic_nervous2.64726465
12MP0002572_abnormal_emotion/affect_behav2.59262883
13MP0002272_abnormal_nervous_system2.56319864
14MP0002734_abnormal_mechanical_nocicepti2.51044118
15MP0002736_abnormal_nociception_after2.47158531
16MP0001440_abnormal_grooming_behavior2.30492401
17MP0002735_abnormal_chemical_nociception2.27176089
18MP0003123_paternal_imprinting2.20444527
19MP0002067_abnormal_sensory_capabilities2.13552165
20MP0002822_catalepsy2.09223647
21MP0001501_abnormal_sleep_pattern2.08376928
22MP0001970_abnormal_pain_threshold2.03512493
23MP0004142_abnormal_muscle_tone2.01453891
24MP0005646_abnormal_pituitary_gland1.95366327
25MP0002733_abnormal_thermal_nociception1.89540968
26MP0005379_endocrine/exocrine_gland_phen1.85684009
27MP0003122_maternal_imprinting1.84317156
28MP0005645_abnormal_hypothalamus_physiol1.81171896
29MP0001529_abnormal_vocalization1.77095807
30MP0003787_abnormal_imprinting1.75379651
31MP0008569_lethality_at_weaning1.74209988
32MP0006276_abnormal_autonomic_nervous1.70539446
33MP0000778_abnormal_nervous_system1.70043158
34MP0002557_abnormal_social/conspecific_i1.68290835
35MP0001188_hyperpigmentation1.66330608
36MP0002184_abnormal_innervation1.63712070
37MP0000955_abnormal_spinal_cord1.56114648
38MP0006072_abnormal_retinal_apoptosis1.53440096
39MP0004924_abnormal_behavior1.52746701
40MP0005386_behavior/neurological_phenoty1.52746701
41MP0004742_abnormal_vestibular_system1.50457729
42MP0004130_abnormal_muscle_cell1.49440069
43MP0001905_abnormal_dopamine_level1.42042717
44MP0001984_abnormal_olfaction1.41088202
45MP0002882_abnormal_neuron_morphology1.40865977
46MP0001502_abnormal_circadian_rhythm1.39869783
47MP0002066_abnormal_motor_capabilities/c1.34721340
48MP0003646_muscle_fatigue1.34552899
49MP0004811_abnormal_neuron_physiology1.34196824
50MP0003879_abnormal_hair_cell1.33815895
51MP0002638_abnormal_pupillary_reflex1.29938805
52MP0005551_abnormal_eye_electrophysiolog1.29400870
53MP0004885_abnormal_endolymph1.27668512
54MP0003329_amyloid_beta_deposits1.25020809
55MP0000749_muscle_degeneration1.23371494
56MP0003633_abnormal_nervous_system1.22366361
57MP0005623_abnormal_meninges_morphology1.17629802
58MP0002837_dystrophic_cardiac_calcinosis1.17566196
59MP0000920_abnormal_myelination1.14327664
60MP0009780_abnormal_chondrocyte_physiolo1.14317587
61MP0010386_abnormal_urinary_bladder1.11132739
62MP0002229_neurodegeneration1.07050226
63MP0003631_nervous_system_phenotype1.06367392
64MP0004036_abnormal_muscle_relaxation1.05943725
65MP0005171_absent_coat_pigmentation1.04822385
66MP0004858_abnormal_nervous_system1.03560309
67MP0001986_abnormal_taste_sensitivity1.03297611
68MP0003137_abnormal_impulse_conducting1.00938652
69MP0002152_abnormal_brain_morphology0.99549296
70MP0003634_abnormal_glial_cell0.99416423
71MP0000631_abnormal_neuroendocrine_gland0.98499148
72MP0003690_abnormal_glial_cell0.97962534
73MP0002909_abnormal_adrenal_gland0.96623998
74MP0004145_abnormal_muscle_electrophysio0.96468818
75MP0004215_abnormal_myocardial_fiber0.94970950
76MP0004510_myositis0.93962243
77MP0001963_abnormal_hearing_physiology0.92051053
78MP0005253_abnormal_eye_physiology0.91170057
79MP0001485_abnormal_pinna_reflex0.90537990
80MP0002752_abnormal_somatic_nervous0.90271297
81MP0000747_muscle_weakness0.88667714
82MP0002234_abnormal_pharynx_morphology0.86443082
83MP0006292_abnormal_olfactory_placode0.86400260
84MP0003632_abnormal_nervous_system0.85196327
85MP0002069_abnormal_eating/drinking_beha0.83073373
86MP0002653_abnormal_ependyma_morphology0.81970352
87MP0005409_darkened_coat_color0.80167951
88MP0001346_abnormal_lacrimal_gland0.79678615
89MP0008874_decreased_physiological_sensi0.79366124
90MP0008872_abnormal_physiological_respon0.78446571
91MP0001348_abnormal_lacrimal_gland0.77971010
92MP0004484_altered_response_of0.77416785
93MP0002106_abnormal_muscle_physiology0.77393855
94MP0005620_abnormal_muscle_contractility0.75907339
95MP0008877_abnormal_DNA_methylation0.73657898
96MP0004087_abnormal_muscle_fiber0.72933941
97MP0008961_abnormal_basal_metabolism0.72420758
98MP0000604_amyloidosis0.71998708
99MP0000462_abnormal_digestive_system0.70521668
100MP0000751_myopathy0.70250264
101MP0003136_yellow_coat_color0.69307484
102MP0000026_abnormal_inner_ear0.68603982
103MP0005535_abnormal_body_temperature0.66073087
104MP0000759_abnormal_skeletal_muscle0.65826187
105MP0004084_abnormal_cardiac_muscle0.65422684
106MP0001177_atelectasis0.65097632
107MP0001727_abnormal_embryo_implantation0.64935114
108MP0000613_abnormal_salivary_gland0.64931488
109MP0001664_abnormal_digestion0.64675567
110MP0004085_abnormal_heartbeat0.64458995
111MP0002102_abnormal_ear_morphology0.63084654
112MP0001943_abnormal_respiration0.63007046
113MP0002332_abnormal_exercise_endurance0.62630484
114MP0002090_abnormal_vision0.62083074
115MP0005499_abnormal_olfactory_system0.59126539
116MP0005394_taste/olfaction_phenotype0.59126539
117MP0005369_muscle_phenotype0.58771122
118MP0002876_abnormal_thyroid_physiology0.58622915
119MP0002972_abnormal_cardiac_muscle0.58527290
120MP0003172_abnormal_lysosome_physiology0.58069074
121MP0005167_abnormal_blood-brain_barrier0.57458261
122MP0005310_abnormal_salivary_gland0.57112421
123MP0000013_abnormal_adipose_tissue0.56713093
124MP0004147_increased_porphyrin_level0.56623537
125MP0003075_altered_response_to0.56443061
126MP0003121_genomic_imprinting0.55717981
127MP0003283_abnormal_digestive_organ0.55032237

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.20114727
2Myokymia (HP:0002411)5.32456138
3Focal seizures (HP:0007359)5.17446060
4Febrile seizures (HP:0002373)4.98458851
5Epileptic encephalopathy (HP:0200134)4.57323302
6Atonic seizures (HP:0010819)4.41125140
7Visual hallucinations (HP:0002367)4.39319404
8Abnormality of the parathyroid morphology (HP:0011766)3.97147383
9Progressive cerebellar ataxia (HP:0002073)3.88359431
10Progressive inability to walk (HP:0002505)3.75778850
11Generalized tonic-clonic seizures (HP:0002069)3.60617248
12Absence seizures (HP:0002121)3.56274067
13Dialeptic seizures (HP:0011146)3.38298435
14Supranuclear gaze palsy (HP:0000605)3.31658387
15Sudden death (HP:0001699)3.30929491
16Congenital stationary night blindness (HP:0007642)3.30682472
17Broad-based gait (HP:0002136)3.30466959
18Obstructive sleep apnea (HP:0002870)3.27829612
19Ankle clonus (HP:0011448)3.17912312
20Bundle branch block (HP:0011710)3.16436225
21Hyperventilation (HP:0002883)3.13123689
22Hemiparesis (HP:0001269)3.08823903
23Papilledema (HP:0001085)3.06654813
24Muscle fiber inclusion bodies (HP:0100299)3.06112045
25Agitation (HP:0000713)2.99559451
26Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.94959461
27Upper limb muscle weakness (HP:0003484)2.90365449
28Action tremor (HP:0002345)2.88638967
29Depression (HP:0000716)2.88244903
30Diplopia (HP:0000651)2.84989342
31Abnormality of binocular vision (HP:0011514)2.84989342
32Torticollis (HP:0000473)2.83031895
33Anxiety (HP:0000739)2.82908376
34Impaired vibration sensation in the lower limbs (HP:0002166)2.80404994
35Annular pancreas (HP:0001734)2.77755951
36Nemaline bodies (HP:0003798)2.74163868
37Amblyopia (HP:0000646)2.71022882
38Hyporeflexia of lower limbs (HP:0002600)2.70720843
39Difficulty running (HP:0009046)2.65593240
40Exercise-induced myalgia (HP:0003738)2.60299618
41Gaze-evoked nystagmus (HP:0000640)2.59012741
42Hyperthyroidism (HP:0000836)2.56603760
43Mutism (HP:0002300)2.55087025
44Abnormal ciliary motility (HP:0012262)2.53619204
45Urinary bladder sphincter dysfunction (HP:0002839)2.52505929
46Type 1 muscle fiber predominance (HP:0003803)2.50727310
47Focal dystonia (HP:0004373)2.49019460
48Lower limb amyotrophy (HP:0007210)2.43764872
49Sleep apnea (HP:0010535)2.43245318
50Status epilepticus (HP:0002133)2.40420107
51Abnormal eating behavior (HP:0100738)2.39776973
52Neurofibrillary tangles (HP:0002185)2.39524642
53Dysmetria (HP:0001310)2.38372268
54Truncal ataxia (HP:0002078)2.37131346
55Exercise-induced muscle cramps (HP:0003710)2.36915260
56Inability to walk (HP:0002540)2.35133322
57Spastic gait (HP:0002064)2.34622776
58Abnormal hair whorl (HP:0010721)2.34291170
59Tetraplegia (HP:0002445)2.33521349
60Cerebral hypomyelination (HP:0006808)2.33391530
61Muscle fiber splitting (HP:0003555)2.32105163
62Lower limb muscle weakness (HP:0007340)2.31401199
63Heart block (HP:0012722)2.31049216
64Abnormality of the corticospinal tract (HP:0002492)2.29144373
65Fetal akinesia sequence (HP:0001989)2.28302234
66Esotropia (HP:0000565)2.26271904
67Absent/shortened dynein arms (HP:0200106)2.25968237
68Dynein arm defect of respiratory motile cilia (HP:0012255)2.25968237
69Limb dystonia (HP:0002451)2.24811561
70Rigidity (HP:0002063)2.24626789
71Poor eye contact (HP:0000817)2.24188436
72Excessive salivation (HP:0003781)2.23290145
73Drooling (HP:0002307)2.23290145
74Hyperparathyroidism (HP:0000843)2.21955987
75Craniofacial dystonia (HP:0012179)2.20271126
76EMG: myopathic abnormalities (HP:0003458)2.18192944
77Primary atrial arrhythmia (HP:0001692)2.16546958
78Myotonia (HP:0002486)2.16420508
79Hemiplegia (HP:0002301)2.16015641
80Abnormal respiratory motile cilium physiology (HP:0012261)2.14716418
81Prolonged QT interval (HP:0001657)2.13545381
82Dysdiadochokinesis (HP:0002075)2.12655334
83Stereotypic behavior (HP:0000733)2.12513111
84Supraventricular tachycardia (HP:0004755)2.12350613
85Syncope (HP:0001279)2.12097786
86Hypsarrhythmia (HP:0002521)2.11061316
87Specific learning disability (HP:0001328)2.10713371
88Intention tremor (HP:0002080)2.10634620
89Muscle hypertrophy of the lower extremities (HP:0008968)2.10187766
90Urinary urgency (HP:0000012)2.09238297
91Gait imbalance (HP:0002141)2.09096395
92Abnormal atrioventricular conduction (HP:0005150)2.07976830
93Postural instability (HP:0002172)2.07961542
94Abnormality of the lower motor neuron (HP:0002366)2.07544372
95Ventricular fibrillation (HP:0001663)2.06618227
96Atrial fibrillation (HP:0005110)2.06007284
97Rapidly progressive (HP:0003678)2.05163835
98Supraventricular arrhythmia (HP:0005115)2.04988558
99Abnormal EKG (HP:0003115)2.04164299
100Foot dorsiflexor weakness (HP:0009027)2.01785755
101Poor suck (HP:0002033)2.01753595
102Psychosis (HP:0000709)2.00487014
103Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.99995746
104EMG: neuropathic changes (HP:0003445)1.99180186
105Abnormality of the foot musculature (HP:0001436)1.98066550
106Atelectasis (HP:0100750)1.97754879
107Insomnia (HP:0100785)1.96573696
108Failure to thrive in infancy (HP:0001531)1.96552149
109Abnormal social behavior (HP:0012433)1.94954602
110Impaired social interactions (HP:0000735)1.94954602
111Frequent falls (HP:0002359)1.94831641
112Clonus (HP:0002169)1.93244620
113Calf muscle hypertrophy (HP:0008981)1.91257513
114Bowel incontinence (HP:0002607)1.89645183
115Polyphagia (HP:0002591)1.88618875
116Metabolic alkalosis (HP:0200114)1.88238415
117Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.87886688
118Nephroblastoma (Wilms tumor) (HP:0002667)1.87755581
119Cerebral inclusion bodies (HP:0100314)1.87503709
120Akinesia (HP:0002304)1.87073952
121Neuronal loss in central nervous system (HP:0002529)1.84415595
122Rhinitis (HP:0012384)1.82597954
123Epileptiform EEG discharges (HP:0011182)1.82298134
124Bradykinesia (HP:0002067)1.81510189
125Scanning speech (HP:0002168)1.81388267
126Menstrual irregularities (HP:0000858)1.80952105
127Generalized hypotonia (HP:0001290)1.80619510
128Medial flaring of the eyebrow (HP:0010747)1.80023637
129Abnormal respiratory motile cilium morphology (HP:0005938)1.79860857
130Abnormal respiratory epithelium morphology (HP:0012253)1.79860857
131Decreased circulating renin level (HP:0003351)1.79482628
132Impaired vibratory sensation (HP:0002495)1.79307687
133Delusions (HP:0000746)1.79215360
134Megalencephaly (HP:0001355)1.79012524
135Abnormal large intestine physiology (HP:0012700)1.78484944
136Absent speech (HP:0001344)1.78380867
137Pheochromocytoma (HP:0002666)1.76564355
138Impaired smooth pursuit (HP:0007772)1.76109188
139Generalized myoclonic seizures (HP:0002123)1.75142731
140EEG with generalized epileptiform discharges (HP:0011198)1.74288647
141Retinal dysplasia (HP:0007973)1.73616114
142Congenital primary aphakia (HP:0007707)1.73560810
143Embryonal renal neoplasm (HP:0011794)1.72112947
144Protruding tongue (HP:0010808)1.71054928
145Exotropia (HP:0000577)1.70538461

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK35.07706498
2MAP3K94.49723896
3EPHA43.41844281
4MAP3K132.83946982
5CASK2.70136631
6TNIK2.68941943
7GRK12.56220544
8MAP3K42.46569819
9MARK12.34727506
10MAP2K72.33889018
11MAP3K122.01452778
12PRPF4B1.99840463
13PAK61.95082170
14OBSCN1.89727457
15MINK11.86893867
16NTRK21.72398046
17RIPK41.69908805
18UHMK11.69276278
19CDK191.50547823
20CAMKK21.47691233
21DAPK21.43435915
22MAPK121.35024169
23NTRK11.34263832
24GRK51.33375856
25MAPK131.33105911
26MAP2K41.30390675
27CDK51.28109347
28IRAK21.24575930
29SIK21.23709630
30MAP3K111.22940567
31RIPK11.19330931
32OXSR11.17078903
33LIMK11.15432548
34NEK61.12735475
35PLK21.09223509
36BMPR21.08940403
37TTN1.08437497
38STK381.07886643
39LATS21.05262291
40PRKD21.05217461
41PRKCG1.03757541
42MAPK151.02041149
43CAMK2A1.01478946
44PHKG20.99759187
45PHKG10.99759187
46FES0.97952805
47TNK20.96854850
48PKN10.92505277
49CAMKK10.91970996
50TXK0.91205976
51ARAF0.88723023
52FGR0.87567743
53SGK2230.87070530
54SGK4940.87070530
55CAMK40.86374175
56KSR20.84388764
57PRKCE0.82846694
58PRKCH0.82471754
59MAP3K70.82072239
60WNK10.80551832
61PRKD30.80377678
62SGK10.79432476
63DAPK10.79081657
64PIK3CA0.78494635
65PNCK0.78214806
66GRK70.74383493
67FGFR20.73979392
68RET0.71202635
69CAMK10.70144836
70DAPK30.69170331
71ADRBK20.67571546
72MARK20.66874012
73KSR10.66862062
74BRAF0.65106952
75PINK10.64879518
76CDC42BPA0.64693107
77CDK180.64590779
78NME10.64422690
79STK110.64021521
80BCR0.63912195
81PRKCQ0.63718756
82CDK150.63490804
83ICK0.62924740
84TESK10.62866390
85CAMK2B0.62686184
86TYRO30.60717113
87CDK140.59568803
88SGK20.58650508
89PDPK10.57820836
90MAPK100.57285308
91PAK30.56797417
92STK390.56250192
93RPS6KA30.54580861
94CAMK2G0.54532446
95PDK10.53415535
96IRAK10.52909022
97BMPR1B0.52734797
98CDK11A0.52449505
99RAF10.52411636
100ROCK10.52055774
101DYRK1B0.50792714
102BRSK10.50422932
103CAMK1G0.49801588
104TRIB30.49580853
105DMPK0.49083263
106CSNK1G20.48292963
107MAPK40.47347779
108ROCK20.47129661
109FYN0.46223312
110PRKCZ0.45973662
111CAMK2D0.44625707
112ALK0.42764304
113BMX0.42602998
114LMTK20.41689689
115DYRK1A0.40944788
116RPS6KA20.40238222
117MAP3K10.39760986
118SGK30.39559145
119PTK2B0.39460864
120BLK0.39045777
121PRKACA0.38571412
122MAP3K20.38560159
123PRKG10.38129233
124WNK40.38056237
125TAOK10.37798598
126MOS0.36108888
127MUSK0.35203936
128DYRK20.35134204
129PRKAA10.34061308
130MAPK80.33876874
131PRKCA0.32187251
132CAMK1D0.31166430

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.72343769
2Synaptic vesicle cycle_Homo sapiens_hsa047213.21370979
3Morphine addiction_Homo sapiens_hsa050322.64125090
4GABAergic synapse_Homo sapiens_hsa047272.61993317
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.55286635
6Glutamatergic synapse_Homo sapiens_hsa047242.37805256
7Circadian entrainment_Homo sapiens_hsa047132.32197755
8Olfactory transduction_Homo sapiens_hsa047402.18312873
9Amphetamine addiction_Homo sapiens_hsa050312.10521159
10Taste transduction_Homo sapiens_hsa047421.98533295
11Long-term potentiation_Homo sapiens_hsa047201.96675711
12Dopaminergic synapse_Homo sapiens_hsa047281.96610628
13Cholinergic synapse_Homo sapiens_hsa047251.95193310
14Serotonergic synapse_Homo sapiens_hsa047261.90338858
15Insulin secretion_Homo sapiens_hsa049111.86124170
16Phototransduction_Homo sapiens_hsa047441.84752635
17Collecting duct acid secretion_Homo sapiens_hsa049661.81988021
18Salivary secretion_Homo sapiens_hsa049701.79253783
19Cocaine addiction_Homo sapiens_hsa050301.76077155
20Gastric acid secretion_Homo sapiens_hsa049711.72904976
21Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.65956953
22Long-term depression_Homo sapiens_hsa047301.63409984
23Calcium signaling pathway_Homo sapiens_hsa040201.51654056
24Aldosterone synthesis and secretion_Homo sapiens_hsa049251.48027840
25Oxytocin signaling pathway_Homo sapiens_hsa049211.47982704
26Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.47854866
27Renin secretion_Homo sapiens_hsa049241.46109458
28Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.44351007
29Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.30774112
30Cardiac muscle contraction_Homo sapiens_hsa042601.26295688
31Type II diabetes mellitus_Homo sapiens_hsa049301.24440898
32Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.20083828
33Axon guidance_Homo sapiens_hsa043601.17013515
34GnRH signaling pathway_Homo sapiens_hsa049121.16356150
35Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.15354510
36Phosphatidylinositol signaling system_Homo sapiens_hsa040701.15111717
37Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.14802048
38Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.13531687
39cAMP signaling pathway_Homo sapiens_hsa040241.12756962
40Vibrio cholerae infection_Homo sapiens_hsa051101.11276943
41ErbB signaling pathway_Homo sapiens_hsa040121.04451762
42Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.02198512
43Gap junction_Homo sapiens_hsa045401.01653278
44Rheumatoid arthritis_Homo sapiens_hsa053231.00395722
45Type I diabetes mellitus_Homo sapiens_hsa049401.00007072
46Estrogen signaling pathway_Homo sapiens_hsa049150.96592697
47Vascular smooth muscle contraction_Homo sapiens_hsa042700.96202097
48Oxidative phosphorylation_Homo sapiens_hsa001900.92344476
49Glucagon signaling pathway_Homo sapiens_hsa049220.89760417
50Phospholipase D signaling pathway_Homo sapiens_hsa040720.88751886
51MAPK signaling pathway_Homo sapiens_hsa040100.87571552
52cGMP-PKG signaling pathway_Homo sapiens_hsa040220.85169458
53Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.85092678
54Choline metabolism in cancer_Homo sapiens_hsa052310.83868554
55Melanogenesis_Homo sapiens_hsa049160.83516140
56Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.81638734
57Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.79012208
58Dorso-ventral axis formation_Homo sapiens_hsa043200.78033291
59Glioma_Homo sapiens_hsa052140.77152495
60Alzheimers disease_Homo sapiens_hsa050100.76963996
61Vitamin B6 metabolism_Homo sapiens_hsa007500.76266365
62Dilated cardiomyopathy_Homo sapiens_hsa054140.76254123
63Ras signaling pathway_Homo sapiens_hsa040140.75469452
64Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.73388168
65Chemokine signaling pathway_Homo sapiens_hsa040620.73134879
66Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.71647491
67SNARE interactions in vesicular transport_Homo sapiens_hsa041300.67956864
68Bile secretion_Homo sapiens_hsa049760.67053067
69Pancreatic secretion_Homo sapiens_hsa049720.66509058
70Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.66366958
71Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.65258250
72Circadian rhythm_Homo sapiens_hsa047100.64590054
73Thyroid hormone signaling pathway_Homo sapiens_hsa049190.64147084
74Sphingolipid signaling pathway_Homo sapiens_hsa040710.63253097
75Parkinsons disease_Homo sapiens_hsa050120.61216937
76Sulfur relay system_Homo sapiens_hsa041220.59451199
77Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.58798818
78Rap1 signaling pathway_Homo sapiens_hsa040150.58093830
79Carbohydrate digestion and absorption_Homo sapiens_hsa049730.55661514
80African trypanosomiasis_Homo sapiens_hsa051430.55492217
81Thyroid hormone synthesis_Homo sapiens_hsa049180.53934333
82Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.53641778
83Inositol phosphate metabolism_Homo sapiens_hsa005620.53401735
84Longevity regulating pathway - mammal_Homo sapiens_hsa042110.49064220
85Wnt signaling pathway_Homo sapiens_hsa043100.48220180
86Arginine and proline metabolism_Homo sapiens_hsa003300.47691455
87Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.46410503
88Phagosome_Homo sapiens_hsa041450.46244880
89VEGF signaling pathway_Homo sapiens_hsa043700.45869979
90Lysosome_Homo sapiens_hsa041420.45582514
91Neurotrophin signaling pathway_Homo sapiens_hsa047220.44787528
92Ovarian steroidogenesis_Homo sapiens_hsa049130.44184414
93T cell receptor signaling pathway_Homo sapiens_hsa046600.43019457
94Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.42678764
95* Insulin signaling pathway_Homo sapiens_hsa049100.42593010
96Endocytosis_Homo sapiens_hsa041440.42298460
97Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.42002344
98AMPK signaling pathway_Homo sapiens_hsa041520.41171398
99Renal cell carcinoma_Homo sapiens_hsa052110.40400543
100Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.39947049
101Alcoholism_Homo sapiens_hsa050340.38819102
102Regulation of actin cytoskeleton_Homo sapiens_hsa048100.36664617
103Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.35974585
104Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.35933447
105Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.35930133
106Regulation of autophagy_Homo sapiens_hsa041400.35100551
107mTOR signaling pathway_Homo sapiens_hsa041500.35015495
108Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.34536734
109Huntingtons disease_Homo sapiens_hsa050160.33810280
110Tight junction_Homo sapiens_hsa045300.33366748
111Prion diseases_Homo sapiens_hsa050200.33360494
112Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.32072985
113Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.31838220
114Salmonella infection_Homo sapiens_hsa051320.30844822
115Oocyte meiosis_Homo sapiens_hsa041140.30434626
116Glycerophospholipid metabolism_Homo sapiens_hsa005640.30128935
117Endometrial cancer_Homo sapiens_hsa052130.29874004
118Arginine biosynthesis_Homo sapiens_hsa002200.29371315
119beta-Alanine metabolism_Homo sapiens_hsa004100.24670189

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