PPP1R3G

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1triglyceride-rich lipoprotein particle remodeling (GO:0034370)7.37515159
2reverse cholesterol transport (GO:0043691)6.16435069
3high-density lipoprotein particle remodeling (GO:0034375)5.86405983
4low-density lipoprotein particle remodeling (GO:0034374)5.84302123
5alpha-linolenic acid metabolic process (GO:0036109)5.41191188
6plasma lipoprotein particle remodeling (GO:0034369)5.37547403
7protein-lipid complex remodeling (GO:0034368)5.37547403
8macromolecular complex remodeling (GO:0034367)5.37547403
9regulation of cholesterol esterification (GO:0010872)5.37361029
10L-phenylalanine catabolic process (GO:0006559)5.27456513
11erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.27456513
12erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.09606954
13L-phenylalanine metabolic process (GO:0006558)5.09606954
14cellular modified amino acid catabolic process (GO:0042219)4.78928749
15negative regulation of sterol transport (GO:0032372)4.64555138
16negative regulation of cholesterol transport (GO:0032375)4.64555138
17L-serine metabolic process (GO:0006563)4.55551485
18sulfur amino acid catabolic process (GO:0000098)4.53354613
19positive regulation of cellular amide metabolic process (GO:0034250)4.52193726
20fucose catabolic process (GO:0019317)4.49937316
21L-fucose metabolic process (GO:0042354)4.49937316
22L-fucose catabolic process (GO:0042355)4.49937316
23phospholipid efflux (GO:0033700)4.47435428
24aromatic amino acid family catabolic process (GO:0009074)4.42680835
25alanine transport (GO:0032328)4.42510510
26homocysteine metabolic process (GO:0050667)4.39344660
27plasma lipoprotein particle organization (GO:0071827)4.36744522
28cellular response to cholesterol (GO:0071397)4.32379731
29regulation of cholesterol biosynthetic process (GO:0045540)4.30955715
30plasma lipoprotein particle assembly (GO:0034377)4.30875508
31negative regulation of astrocyte differentiation (GO:0048712)4.30698983
32cysteine metabolic process (GO:0006534)4.29586497
33behavioral response to nicotine (GO:0035095)4.28758114
34amino-acid betaine metabolic process (GO:0006577)4.13653407
35serine family amino acid catabolic process (GO:0009071)4.12612525
36glutamate metabolic process (GO:0006536)4.09287929
37glyoxylate metabolic process (GO:0046487)4.07560929
38protein-lipid complex subunit organization (GO:0071825)4.04287100
39regulation of triglyceride catabolic process (GO:0010896)3.98523858
40dicarboxylic acid biosynthetic process (GO:0043650)3.93870701
41carnitine metabolic process (GO:0009437)3.92660684
42positive regulation of triglyceride biosynthetic process (GO:0010867)3.92422564
43cholesterol catabolic process (GO:0006707)3.90936779
44sterol catabolic process (GO:0016127)3.90936779
45glutamine family amino acid biosynthetic process (GO:0009084)3.84622763
46ethanol oxidation (GO:0006069)3.82146728
47alpha-amino acid catabolic process (GO:1901606)3.80163720
48serine family amino acid biosynthetic process (GO:0009070)3.79644137
49cellular response to sterol (GO:0036315)3.78896746
50indole-containing compound catabolic process (GO:0042436)3.77510856
51indolalkylamine catabolic process (GO:0046218)3.77510856
52tryptophan catabolic process (GO:0006569)3.77510856
53linoleic acid metabolic process (GO:0043651)3.75730199
54protein-lipid complex assembly (GO:0065005)3.75628726
55very-low-density lipoprotein particle assembly (GO:0034379)3.75434161
56bile acid biosynthetic process (GO:0006699)3.75039210
57dicarboxylic acid catabolic process (GO:0043649)3.73317551
58urea cycle (GO:0000050)3.73048587
59urea metabolic process (GO:0019627)3.73048587
60cholesterol efflux (GO:0033344)3.73029461
61purine nucleotide transport (GO:0015865)3.72566106
62short-chain fatty acid metabolic process (GO:0046459)3.67868429
63regulation of cholesterol metabolic process (GO:0090181)3.66916982
64positive regulation of triglyceride metabolic process (GO:0090208)3.64958606
65kynurenine metabolic process (GO:0070189)3.63303463
66negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.62221743
67cellular amino acid catabolic process (GO:0009063)3.61240688
68regulation of cholesterol homeostasis (GO:2000188)3.59743967
69adenine nucleotide transport (GO:0051503)3.57886097
70plasma lipoprotein particle clearance (GO:0034381)3.57395168
71neurotransmitter-gated ion channel clustering (GO:0072578)3.56096415
72response to pheromone (GO:0019236)3.54013172
73platelet dense granule organization (GO:0060155)3.53069006
74water-soluble vitamin biosynthetic process (GO:0042364)3.52205976
75very long-chain fatty acid metabolic process (GO:0000038)3.48983349
76coenzyme catabolic process (GO:0009109)3.48576786
77negative regulation of fibrinolysis (GO:0051918)3.48171375
78tryptophan metabolic process (GO:0006568)3.44041659
79regulation of triglyceride biosynthetic process (GO:0010866)3.40758953
80positive regulation of action potential (GO:0045760)3.38159251
81regulation of fibrinolysis (GO:0051917)3.37045540
82nitrogen cycle metabolic process (GO:0071941)3.36925009
83negative regulation of response to reactive oxygen species (GO:1901032)3.35722743
84nephron epithelium morphogenesis (GO:0072088)3.35030656
85nephron tubule morphogenesis (GO:0072078)3.35030656
86serine family amino acid metabolic process (GO:0009069)3.31239836
87lipoprotein metabolic process (GO:0042157)3.31015490
88negative regulation of telomere maintenance (GO:0032205)3.30793241
89fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.30323642
90purine ribonucleotide transport (GO:0015868)3.30305303
91fatty acid homeostasis (GO:0055089)3.26913253
92glutamine family amino acid catabolic process (GO:0009065)3.26227210
93fructose metabolic process (GO:0006000)3.24421476
94arginine metabolic process (GO:0006525)3.24141094
95dopamine transport (GO:0015872)3.20619359
96aspartate family amino acid catabolic process (GO:0009068)3.19474178
97bile acid metabolic process (GO:0008206)3.19399789
98regulation of triglyceride metabolic process (GO:0090207)3.18197273
99regulation of beta-amyloid formation (GO:1902003)3.17603531
100tyrosine metabolic process (GO:0006570)3.17423548
101positive regulation of fatty acid beta-oxidation (GO:0032000)3.17063715
102cornea development in camera-type eye (GO:0061303)3.16726585
103basic amino acid transport (GO:0015802)3.15338215
104indolalkylamine metabolic process (GO:0006586)3.15116874
105respiratory chain complex IV assembly (GO:0008535)3.13536068
106negative regulation of lipase activity (GO:0060192)3.12019003
107positive regulation of steroid metabolic process (GO:0045940)3.11229459
108lysine metabolic process (GO:0006553)3.10835821
109lysine catabolic process (GO:0006554)3.10835821
110positive regulation of fatty acid transport (GO:2000193)3.10259575
111negative regulation of hydrogen peroxide-induced cell death (GO:1903206)3.09902302
112aromatic amino acid family metabolic process (GO:0009072)3.09834474
1132-oxoglutarate metabolic process (GO:0006103)3.08789032
114flavonoid metabolic process (GO:0009812)3.06507267
115positive regulation of fatty acid oxidation (GO:0046321)3.05164702
116cellular ketone body metabolic process (GO:0046950)3.05113280
117gap junction assembly (GO:0016264)3.04828718
118kidney morphogenesis (GO:0060993)3.02252364
119regulation of action potential (GO:0098900)2.96577286
120S-adenosylmethionine metabolic process (GO:0046500)2.96538117
121piRNA metabolic process (GO:0034587)2.96042424
122C4-dicarboxylate transport (GO:0015740)2.95184235
123DNA deamination (GO:0045006)2.94940368
124ketone body metabolic process (GO:1902224)2.94922221
125epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.93503991
126preassembly of GPI anchor in ER membrane (GO:0016254)2.93318028
127exogenous drug catabolic process (GO:0042738)2.89842583
128pyrimidine nucleobase catabolic process (GO:0006208)2.87331797
129mitochondrial respiratory chain complex I assembly (GO:0032981)2.85873951
130NADH dehydrogenase complex assembly (GO:0010257)2.85873951
131mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.85873951
132renal tubule morphogenesis (GO:0061333)2.84078567
133regulation of cytokine production involved in inflammatory response (GO:1900015)2.83745398
134positive regulation of icosanoid secretion (GO:0032305)2.82703338
135regulation of hexokinase activity (GO:1903299)2.79602603
136regulation of glucokinase activity (GO:0033131)2.79602603
137positive regulation of defense response to virus by host (GO:0002230)2.78245632
138negative regulation of cytosolic calcium ion concentration (GO:0051481)2.77044476
139detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.74209021
140primary amino compound metabolic process (GO:1901160)2.72317872
141protein complex biogenesis (GO:0070271)2.72194295
142regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:00033392.71884107
143detection of light stimulus involved in visual perception (GO:0050908)2.71299582
144detection of light stimulus involved in sensory perception (GO:0050962)2.71299582
145positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)2.67742053
146drug catabolic process (GO:0042737)2.67468928
147protein polyglutamylation (GO:0018095)2.67136669
148L-methionine salvage (GO:0071267)2.65116606
149L-methionine biosynthetic process (GO:0071265)2.65116606
150amino acid salvage (GO:0043102)2.65116606
151auditory receptor cell stereocilium organization (GO:0060088)2.64209063
152positive regulation of prostaglandin secretion (GO:0032308)2.60811239
153positive regulation of mitochondrial fission (GO:0090141)2.60737625
154L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.60622776
155cellular response to ATP (GO:0071318)2.60067533
156cytochrome complex assembly (GO:0017004)2.58830979
157cell proliferation in forebrain (GO:0021846)2.58339657
158negative regulation of mast cell activation (GO:0033004)2.58030338
159mannosylation (GO:0097502)2.57366650
160organic cation transport (GO:0015695)2.54940074
161regulation of tyrosine phosphorylation of Stat5 protein (GO:0042522)2.53731276
162behavioral response to ethanol (GO:0048149)2.53600508
163indole-containing compound metabolic process (GO:0042430)2.53505774
164cilium morphogenesis (GO:0060271)2.53388662
165positive regulation of organic acid transport (GO:0032892)2.51984954
166substrate-independent telencephalic tangential migration (GO:0021826)2.51528641
167substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.51528641
168membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.51496508
169aldehyde catabolic process (GO:0046185)2.47903812
170nucleobase catabolic process (GO:0046113)2.47521032
171positive regulation of gastrulation (GO:2000543)2.47379776
172neurotransmitter metabolic process (GO:0042133)2.46969066
173fucosylation (GO:0036065)2.46911140
174retinal cone cell development (GO:0046549)2.46697101
175mitochondrial respiratory chain complex assembly (GO:0033108)2.45735609
176amine catabolic process (GO:0009310)2.44649141
177cellular biogenic amine catabolic process (GO:0042402)2.44649141
178neuronal action potential (GO:0019228)2.39856231
179protein-cofactor linkage (GO:0018065)2.38688799
180epithelial cilium movement (GO:0003351)2.38313263
181somite development (GO:0061053)2.38005944
1823-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.36256444
183purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.36256444
184inner ear receptor stereocilium organization (GO:0060122)2.35649249
185endoderm formation (GO:0001706)2.35034682

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse8.61444790
2* RXR_22158963_ChIP-Seq_LIVER_Mouse5.59435923
3* PPARA_22158963_ChIP-Seq_LIVER_Mouse4.60493421
4* LXR_22158963_ChIP-Seq_LIVER_Mouse4.38337118
5* FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.35406301
6EGR1_23403033_ChIP-Seq_LIVER_Mouse3.91784862
7ZNF274_21170338_ChIP-Seq_K562_Hela3.61714294
8PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.60720076
9VDR_22108803_ChIP-Seq_LS180_Human2.97885250
10NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.65190719
11PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.64989509
12CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.62050149
13FLI1_27457419_Chip-Seq_LIVER_Mouse2.57184716
14THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.55319760
15IGF1R_20145208_ChIP-Seq_DFB_Human2.29146122
16ZFP57_27257070_Chip-Seq_ESCs_Mouse2.29136077
17CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.10408910
18PCGF2_27294783_Chip-Seq_ESCs_Mouse2.10122262
19SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.86728328
20SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.83218593
21TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.82807878
22POU3F2_20337985_ChIP-ChIP_501MEL_Human1.74948062
23SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.72085428
24AR_21572438_ChIP-Seq_LNCaP_Human1.68708860
25EED_16625203_ChIP-ChIP_MESCs_Mouse1.68648843
26HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.64556767
27NOTCH1_21737748_ChIP-Seq_TLL_Human1.62282118
28EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.62107979
29PCGF2_27294783_Chip-Seq_NPCs_Mouse1.61795264
30TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.61371692
31ER_23166858_ChIP-Seq_MCF-7_Human1.61057756
32HTT_18923047_ChIP-ChIP_STHdh_Human1.58077774
33MTF2_20144788_ChIP-Seq_MESCs_Mouse1.56230723
34TAF15_26573619_Chip-Seq_HEK293_Human1.54414201
35FUS_26573619_Chip-Seq_HEK293_Human1.53135799
36EZH2_22144423_ChIP-Seq_EOC_Human1.51796935
37* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.49444239
38SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.49374319
39TRIM28_21343339_ChIP-Seq_HEK293_Human1.45814606
40GBX2_23144817_ChIP-Seq_PC3_Human1.45554299
41SUZ12_27294783_Chip-Seq_NPCs_Mouse1.45254554
42SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.42913832
43TP53_22573176_ChIP-Seq_HFKS_Human1.42813306
44EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.40887893
45SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.40007976
46IRF1_19129219_ChIP-ChIP_H3396_Human1.39896476
47SMAD3_21741376_ChIP-Seq_EPCs_Human1.38417651
48RNF2_18974828_ChIP-Seq_MESCs_Mouse1.38187918
49EZH2_18974828_ChIP-Seq_MESCs_Mouse1.38187918
50* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.38124505
51ERG_21242973_ChIP-ChIP_JURKAT_Human1.37445602
52GABP_17652178_ChIP-ChIP_JURKAT_Human1.37335703
53CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.33838317
54MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.33365715
55* RNF2_27304074_Chip-Seq_ESCs_Mouse1.31017781
56NFE2_27457419_Chip-Seq_LIVER_Mouse1.30593897
57CLOCK_20551151_ChIP-Seq_293T_Human1.29755261
58BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.29447402
59BMI1_23680149_ChIP-Seq_NPCS_Mouse1.28935523
60EWS_26573619_Chip-Seq_HEK293_Human1.28464928
61ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.28007243
62IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.27276110
63CBP_20019798_ChIP-Seq_JUKART_Human1.27276110
64MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.26855490
65STAT3_23295773_ChIP-Seq_U87_Human1.26548318
66KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.26215441
67JARID2_20064375_ChIP-Seq_MESCs_Mouse1.26152500
68* SOX2_19829295_ChIP-Seq_ESCs_Human1.25215518
69* NANOG_19829295_ChIP-Seq_ESCs_Human1.25215518
70FOXA2_19822575_ChIP-Seq_HepG2_Human1.24109338
71ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.23131025
72* AR_20517297_ChIP-Seq_VCAP_Human1.22756731
73HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.21489046
74ESR2_21235772_ChIP-Seq_MCF-7_Human1.20687656
75BCAT_22108803_ChIP-Seq_LS180_Human1.20560517
76* EZH2_27294783_Chip-Seq_ESCs_Mouse1.20520329
77EZH2_27294783_Chip-Seq_NPCs_Mouse1.20373197
78GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.20158405
79E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.19999303
80SMAD4_21799915_ChIP-Seq_A2780_Human1.18799356
81ETV2_25802403_ChIP-Seq_MESCs_Mouse1.18487730
82TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.18149732
83IKZF1_21737484_ChIP-ChIP_HCT116_Human1.17741456
84RUNX2_22187159_ChIP-Seq_PCA_Human1.17518177
85TCF4_22108803_ChIP-Seq_LS180_Human1.16767726
86SMAD4_21741376_ChIP-Seq_EPCs_Human1.16597284
87DROSHA_22980978_ChIP-Seq_HELA_Human1.16447668
88GATA3_21878914_ChIP-Seq_MCF-7_Human1.15993119
89REST_21632747_ChIP-Seq_MESCs_Mouse1.14526595
90FOXA1_27270436_Chip-Seq_PROSTATE_Human1.14493620
91FOXA1_25329375_ChIP-Seq_VCAP_Human1.14493620
92TCF4_23295773_ChIP-Seq_U87_Human1.14404285
93KLF5_20875108_ChIP-Seq_MESCs_Mouse1.14245485
94RXR_22108803_ChIP-Seq_LS180_Human1.11366360
95MYC_18940864_ChIP-ChIP_HL60_Human1.10860427
96TOP2B_26459242_ChIP-Seq_MCF-7_Human1.10622334
97SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.09555710
98* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.09173804
99AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.07900421
100FLI1_21867929_ChIP-Seq_TH2_Mouse1.05750337
101KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.03656527
102CRX_20693478_ChIP-Seq_RETINA_Mouse1.03298224
103TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.03121289
104MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.03059371
105SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.01882424
106PIAS1_25552417_ChIP-Seq_VCAP_Human1.01745967
107SRF_21415370_ChIP-Seq_HL-1_Mouse1.00602984
108CDX2_19796622_ChIP-Seq_MESCs_Mouse1.00250628
109MYC_19829295_ChIP-Seq_ESCs_Human0.97071995
110RNF2_27304074_Chip-Seq_NSC_Mouse0.96989527
111DNAJC2_21179169_ChIP-ChIP_NT2_Human0.96585493
112FOXH1_21741376_ChIP-Seq_ESCs_Human0.96517506
113CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.96040145
114PRDM14_20953172_ChIP-Seq_ESCs_Human0.95561001
115* NCOR_22424771_ChIP-Seq_293T_Human0.95165265
116FOXH1_21741376_ChIP-Seq_EPCs_Human0.95161970
117LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.94973352
118* EZH2_27304074_Chip-Seq_ESCs_Mouse0.93798486
119EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.93763252
120PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.93544606
121ERA_21632823_ChIP-Seq_H3396_Human0.93003972
122REST_18959480_ChIP-ChIP_MESCs_Mouse0.91074289
123RING1B_27294783_Chip-Seq_ESCs_Mouse0.90577380
124HNF4A_19822575_ChIP-Seq_HepG2_Human0.88670110
125ESR1_15608294_ChIP-ChIP_MCF-7_Human0.87786350
126GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86348909
127NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.84486043
128TP53_18474530_ChIP-ChIP_U2OS_Human0.84467126
129RARB_27405468_Chip-Seq_BRAIN_Mouse0.84106111
130NR3C1_21868756_ChIP-Seq_MCF10A_Human0.83851100
131NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.83202691
132RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.82587663
133MYC_27129775_Chip-Seq_CORNEA_Mouse0.81922213
134NR3C1_23031785_ChIP-Seq_PC12_Mouse0.81396378
135SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.81301334
136TP53_20018659_ChIP-ChIP_R1E_Mouse0.81010684
137NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.77978788
138NRF2_20460467_ChIP-Seq_MEFs_Mouse0.77978788
139PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.77653614
140AUTS2_25519132_ChIP-Seq_293T-REX_Human0.75790501
141* TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.75585804
142P300_19829295_ChIP-Seq_ESCs_Human0.74676430
143RAD21_21589869_ChIP-Seq_MESCs_Mouse0.73611813
144ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.73365470
145PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.73206353
146UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.73013905
147CTBP2_25329375_ChIP-Seq_LNCAP_Human0.71788566
148GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.71135198
149SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.70211129
150HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.69631364
151CTBP1_25329375_ChIP-Seq_LNCAP_Human0.69613532
152LXR_22292898_ChIP-Seq_THP-1_Human0.69052416
153AR_25329375_ChIP-Seq_VCAP_Human0.68762498
154SMAD4_21741376_ChIP-Seq_HESCs_Human0.68280677
155SOX2_21211035_ChIP-Seq_LN229_Gbm0.67600353
156RARG_19884340_ChIP-ChIP_MEFs_Mouse0.67173137
157AR_19668381_ChIP-Seq_PC3_Human0.66370338
158CBX2_27304074_Chip-Seq_ESCs_Mouse0.65196916
159CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.64622534
160ZNF217_24962896_ChIP-Seq_MCF-7_Human0.64126816
161WT1_25993318_ChIP-Seq_PODOCYTE_Human0.63929176
162RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.62977108
163TP53_16413492_ChIP-PET_HCT116_Human0.62031192
164AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.61841928
165ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.61650188
166TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.61615561
167POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.61615561

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.97347291
2MP0005360_urolithiasis4.83278066
3MP0009840_abnormal_foam_cell4.75668111
4MP0005365_abnormal_bile_salt4.24886434
5MP0005085_abnormal_gallbladder_physiolo4.11199151
6MP0002254_reproductive_system_inflammat3.90573208
7MP0008875_abnormal_xenobiotic_pharmacok3.33098329
8MP0003011_delayed_dark_adaptation3.23196065
9MP0010329_abnormal_lipoprotein_level3.19310472
10MP0005332_abnormal_amino_acid3.05726127
11MP0003329_amyloid_beta_deposits2.98759465
12MP0003690_abnormal_glial_cell2.81700586
13MP0003806_abnormal_nucleotide_metabolis2.73043173
14MP0003283_abnormal_digestive_organ2.60807784
15MP0005646_abnormal_pituitary_gland2.60250339
16MP0000569_abnormal_digit_pigmentation2.58591782
17MP0006072_abnormal_retinal_apoptosis2.58347173
18MP0002837_dystrophic_cardiac_calcinosis2.57739489
19MP0001968_abnormal_touch/_nociception2.25335509
20MP0000604_amyloidosis2.20729852
21MP0004147_increased_porphyrin_level2.19946105
22MP0003252_abnormal_bile_duct2.18533405
23MP0000566_synostosis2.16171510
24MP0002736_abnormal_nociception_after2.13237768
25MP0009384_cardiac_valve_regurgitation2.06958606
26MP0004858_abnormal_nervous_system2.06030481
27MP0001986_abnormal_taste_sensitivity1.96412706
28MP0002234_abnormal_pharynx_morphology1.88649349
29MP0009780_abnormal_chondrocyte_physiolo1.86573153
30MP0002638_abnormal_pupillary_reflex1.86524222
31MP0002938_white_spotting1.83166959
32MP0002102_abnormal_ear_morphology1.80353647
33MP0002118_abnormal_lipid_homeostasis1.76196421
34MP0001853_heart_inflammation1.74408488
35MP0005083_abnormal_biliary_tract1.73003118
36MP0003191_abnormal_cellular_cholesterol1.71593751
37MP0001502_abnormal_circadian_rhythm1.67004035
38MP0003279_aneurysm1.66660461
39MP0004019_abnormal_vitamin_homeostasis1.66056853
40MP0004859_abnormal_synaptic_plasticity1.59837742
41MP0001666_abnormal_nutrient_absorption1.51036509
42MP0003195_calcinosis1.50382445
43MP0003075_altered_response_to1.46823795
44MP0002272_abnormal_nervous_system1.46758500
45MP0010368_abnormal_lymphatic_system1.46645203
46MP0002138_abnormal_hepatobiliary_system1.45511644
47MP0004885_abnormal_endolymph1.45441789
48MP0008775_abnormal_heart_ventricle1.45416539
49MP0001486_abnormal_startle_reflex1.44721876
50MP0002933_joint_inflammation1.40759840
51MP0000609_abnormal_liver_physiology1.39597858
52MP0003787_abnormal_imprinting1.35340712
53MP0008877_abnormal_DNA_methylation1.34261060
54MP0004130_abnormal_muscle_cell1.34051901
55MP0005377_hearing/vestibular/ear_phenot1.29898504
56MP0003878_abnormal_ear_physiology1.29898504
57MP0005584_abnormal_enzyme/coenzyme_acti1.29456566
58MP0005647_abnormal_sex_gland1.27823035
59MP0003186_abnormal_redox_activity1.27548438
60MP0004133_heterotaxia1.23572119
61MP0003868_abnormal_feces_composition1.21152336
62MP0005671_abnormal_response_to1.17737581
63MP0005645_abnormal_hypothalamus_physiol1.17698873
64MP0003122_maternal_imprinting1.16486076
65MP0001440_abnormal_grooming_behavior1.16410089
66MP0005670_abnormal_white_adipose1.16205826
67MP0002090_abnormal_vision1.15780094
68MP0002909_abnormal_adrenal_gland1.14104605
69MP0009764_decreased_sensitivity_to1.12517738
70MP0001984_abnormal_olfaction1.12185516
71MP0002277_abnormal_respiratory_mucosa1.11106693
72MP0003705_abnormal_hypodermis_morpholog1.10488348
73MP0003656_abnormal_erythrocyte_physiolo1.10286899
74MP0005379_endocrine/exocrine_gland_phen1.09243849
75MP0000427_abnormal_hair_cycle1.09211673
76MP0004215_abnormal_myocardial_fiber1.06409687
77MP0005195_abnormal_posterior_eye1.05573351
78MP0005319_abnormal_enzyme/_coenzyme1.05103794
79MP0005174_abnormal_tail_pigmentation1.02982670
80MP0001661_extended_life_span1.02124319
81MP0001764_abnormal_homeostasis1.01225735
82MP0000049_abnormal_middle_ear1.01157366
83MP0003880_abnormal_central_pattern1.00976590
84MP0001970_abnormal_pain_threshold1.00812901
85MP0005167_abnormal_blood-brain_barrier0.99013639
86MP0000778_abnormal_nervous_system0.97772374
87MP0002067_abnormal_sensory_capabilities0.97650325
88MP0005503_abnormal_tendon_morphology0.95687012
89MP0002572_abnormal_emotion/affect_behav0.94994980
90MP0000372_irregular_coat_pigmentation0.94719873
91MP0003635_abnormal_synaptic_transmissio0.94316824
92MP0008789_abnormal_olfactory_epithelium0.94295170
93MP0000026_abnormal_inner_ear0.94100614
94MP0001485_abnormal_pinna_reflex0.93079081
95MP0003119_abnormal_digestive_system0.92452879
96MP0006276_abnormal_autonomic_nervous0.91658648
97MP0004043_abnormal_pH_regulation0.91389896
98MP0002735_abnormal_chemical_nociception0.90848730
99MP0003137_abnormal_impulse_conducting0.90320344
100MP0002064_seizures0.90299313
101MP0002127_abnormal_cardiovascular_syste0.89136095
102MP0002063_abnormal_learning/memory/cond0.88073962
103MP0003136_yellow_coat_color0.87989129
104MP0005551_abnormal_eye_electrophysiolog0.87868737
105MP0003633_abnormal_nervous_system0.87386469
106MP0001324_abnormal_eye_pigmentation0.86916287
107MP0000639_abnormal_adrenal_gland0.84906376
108MP0000631_abnormal_neuroendocrine_gland0.83178854
109MP0003718_maternal_effect0.82853717
110MP0009745_abnormal_behavioral_response0.82762560
111MP0009697_abnormal_copulation0.81661026
112MP0005595_abnormal_vascular_smooth0.80128154
113MP0004883_abnormal_blood_vessel0.79556093
114MP0003634_abnormal_glial_cell0.79521730
115MP0004084_abnormal_cardiac_muscle0.79477168
116MP0003632_abnormal_nervous_system0.78552886
117MP0010030_abnormal_orbit_morphology0.77743978
118MP0002282_abnormal_trachea_morphology0.77095435
119MP0003121_genomic_imprinting0.76989226
120MP0003567_abnormal_fetal_cardiomyocyte0.76962565
121MP0000230_abnormal_systemic_arterial0.75933638
122MP0000613_abnormal_salivary_gland0.75564090
123MP0005451_abnormal_body_composition0.75496418
124MP0004742_abnormal_vestibular_system0.75204451
125MP0003631_nervous_system_phenotype0.74699672
126MP0005084_abnormal_gallbladder_morpholo0.74215366
127MP0005535_abnormal_body_temperature0.73884070
128MP0000015_abnormal_ear_pigmentation0.73406927
129MP0002693_abnormal_pancreas_physiology0.72461805
130MP0010386_abnormal_urinary_bladder0.71855733
131MP0002876_abnormal_thyroid_physiology0.71120491
132MP0005166_decreased_susceptibility_to0.70545210
133MP0002971_abnormal_brown_adipose0.69467714
134MP0002557_abnormal_social/conspecific_i0.68091496
135MP0001501_abnormal_sleep_pattern0.67229638
136MP0005165_increased_susceptibility_to0.65703125
137MP0009643_abnormal_urine_homeostasis0.65307531
138MP0005376_homeostasis/metabolism_phenot0.63675903
139MP0008874_decreased_physiological_sensi0.63584635
140MP0003638_abnormal_response/metabolism_0.62030170
141MP0002733_abnormal_thermal_nociception0.61456024
142MP0006292_abnormal_olfactory_placode0.61385101
143MP0000647_abnormal_sebaceous_gland0.60402638
144MP0009046_muscle_twitch0.60275553
145MP0005666_abnormal_adipose_tissue0.59462747
146MP0004142_abnormal_muscle_tone0.58557873
147MP0003646_muscle_fatigue0.56475227
148MP0002822_catalepsy0.55353961
149MP0001529_abnormal_vocalization0.54371229
150MP0009642_abnormal_blood_homeostasis0.53020009
151MP0001881_abnormal_mammary_gland0.50741685
152MP0002078_abnormal_glucose_homeostasis0.50437621
153MP0005386_behavior/neurological_phenoty0.50170110
154MP0004924_abnormal_behavior0.50170110
155MP0005164_abnormal_response_to0.48732859
156MP0005253_abnormal_eye_physiology0.48537649
157MP0001905_abnormal_dopamine_level0.47645537
158MP0008872_abnormal_physiological_respon0.47563817

Predicted human phenotypes

RankGene SetZ-score
1Xanthomatosis (HP:0000991)6.34990434
2Hyperlipoproteinemia (HP:0010980)6.06500718
3Abnormality of aromatic amino acid family metabolism (HP:0004338)5.37920916
4Hypoalphalipoproteinemia (HP:0003233)5.21869429
5Hyperglycinuria (HP:0003108)4.67371419
6Neurofibrillary tangles (HP:0002185)4.66330660
7Deep venous thrombosis (HP:0002625)4.66298200
8Megalencephaly (HP:0001355)4.53257355
9Abnormality of glycine metabolism (HP:0010895)4.52090641
10Abnormality of serine family amino acid metabolism (HP:0010894)4.52090641
11Aplasia of the phalanges of the hand (HP:0009802)4.43255249
12Aplasia involving bones of the extremities (HP:0009825)4.43255249
13Aplasia involving bones of the upper limbs (HP:0009823)4.43255249
14Abnormality of monocarboxylic acid metabolism (HP:0010996)4.34643818
15Hypolipoproteinemia (HP:0010981)4.33976640
16Prolonged partial thromboplastin time (HP:0003645)4.30706613
17Intrahepatic cholestasis (HP:0001406)4.23507803
18Pancreatic cysts (HP:0001737)4.20682758
19Congenital stationary night blindness (HP:0007642)4.07759523
20Hyperglycinemia (HP:0002154)4.05516911
21Hyperammonemia (HP:0001987)4.03124464
22Abnormality of the axillary hair (HP:0100134)3.94365185
23Abnormality of secondary sexual hair (HP:0009888)3.94365185
24Nephronophthisis (HP:0000090)3.90090710
25Ketosis (HP:0001946)3.87931747
26Hypobetalipoproteinemia (HP:0003563)3.84768431
27Type II lissencephaly (HP:0007260)3.81728037
28Abnormality of midbrain morphology (HP:0002418)3.78442580
29Molar tooth sign on MRI (HP:0002419)3.78442580
30Pancreatic fibrosis (HP:0100732)3.72527538
31Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.67611905
32Abnormality of glutamine family amino acid metabolism (HP:0010902)3.65248042
33Cerebral inclusion bodies (HP:0100314)3.60224244
34True hermaphroditism (HP:0010459)3.59710391
35Abnormality of methionine metabolism (HP:0010901)3.57870785
36Abnormality of sulfur amino acid metabolism (HP:0004339)3.53368519
37Epidermoid cyst (HP:0200040)3.48597980
38Hypercholesterolemia (HP:0003124)3.47291643
39Abnormality of aspartate family amino acid metabolism (HP:0010899)3.22592376
40Back pain (HP:0003418)3.22383161
41Ketoacidosis (HP:0001993)3.13315481
42Late onset (HP:0003584)3.06969302
43Abnormality of the renal medulla (HP:0100957)3.05859017
44Joint hemorrhage (HP:0005261)3.05631518
45Increased corneal curvature (HP:0100692)3.01770103
46Keratoconus (HP:0000563)3.01770103
47Dry hair (HP:0011359)2.97249572
48Hypoplastic left heart (HP:0004383)2.96185164
49Tetraparesis (HP:0002273)2.94510080
50Abnormality of the renal cortex (HP:0011035)2.90548262
51Tubular atrophy (HP:0000092)2.83916940
52Abnormal drinking behavior (HP:0030082)2.74345538
53Polydipsia (HP:0001959)2.74345538
54Pseudobulbar signs (HP:0002200)2.73661856
55Hypoglycemic coma (HP:0001325)2.73277630
56Chronic hepatic failure (HP:0100626)2.68367947
57Status epilepticus (HP:0002133)2.66845207
58Abnormality of proline metabolism (HP:0010907)2.64709787
59Hydroxyprolinuria (HP:0003080)2.64709787
60Cystic liver disease (HP:0006706)2.60809735
61Large for gestational age (HP:0001520)2.60532970
62Confusion (HP:0001289)2.59416098
63Broad alveolar ridges (HP:0000187)2.58311374
64Complement deficiency (HP:0004431)2.55990591
65Clumsiness (HP:0002312)2.50838430
66Delayed CNS myelination (HP:0002188)2.48865717
67Abnormality of serum amino acid levels (HP:0003112)2.48765590
68Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.46825556
69Mitochondrial inheritance (HP:0001427)2.44099299
70Inability to walk (HP:0002540)2.43962263
71Medial flaring of the eyebrow (HP:0010747)2.43946122
72Aplasia/hypoplasia of the uterus (HP:0008684)2.43096569
73Enlarged kidneys (HP:0000105)2.42822159
74Atrioventricular block (HP:0001678)2.42498120
75Sensorimotor neuropathy (HP:0007141)2.42240265
76Amyloidosis (HP:0011034)2.42001276
77Abnormality of pyrimidine metabolism (HP:0004353)2.40954123
78Pendular nystagmus (HP:0012043)2.39405593
79Lissencephaly (HP:0001339)2.38646846
80Abnormality of fatty-acid metabolism (HP:0004359)2.37700461
81Synostosis involving the elbow (HP:0003938)2.37173744
82Humeroradial synostosis (HP:0003041)2.37173744
83Increased CSF lactate (HP:0002490)2.37039169
84Congenital, generalized hypertrichosis (HP:0004540)2.36822617
85Dynein arm defect of respiratory motile cilia (HP:0012255)2.36815563
86Absent/shortened dynein arms (HP:0200106)2.36815563
87Attenuation of retinal blood vessels (HP:0007843)2.36784124
88Acute necrotizing encephalopathy (HP:0006965)2.36319463
89Abnormality of alanine metabolism (HP:0010916)2.35191887
90Hyperalaninemia (HP:0003348)2.35191887
91Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.35191887
92Congenital hepatic fibrosis (HP:0002612)2.32234934
93Cerebellar dysplasia (HP:0007033)2.31863944
94Aplasia/Hypoplasia of the tongue (HP:0010295)2.31102594
95Arthropathy (HP:0003040)2.30698397
96Neonatal hypoglycemia (HP:0001998)2.28902122
97Renal cortical cysts (HP:0000803)2.28111316
98Abolished electroretinogram (ERG) (HP:0000550)2.27402025
99Gout (HP:0001997)2.27264604
100Absent hair (HP:0002298)2.27031366
101Acute encephalopathy (HP:0006846)2.24926367
102Hypoplastic heart (HP:0001961)2.17143928
103Metabolic acidosis (HP:0001942)2.16774075
104Paraparesis (HP:0002385)2.15774041
105Short middle phalanx of the 5th finger (HP:0004220)2.14802877
106Abnormal rod and cone electroretinograms (HP:0008323)2.14351305
107Abnormality of the common coagulation pathway (HP:0010990)2.12463742
108Severe muscular hypotonia (HP:0006829)2.09815248
109Progressive inability to walk (HP:0002505)2.09441628
110Abnormality of binocular vision (HP:0011514)2.08720652
111Diplopia (HP:0000651)2.08720652
112Hypothermia (HP:0002045)2.08610432
113Hypoglycemic seizures (HP:0002173)2.08111852
114Adactyly (HP:0009776)2.08029793
115Progressive macrocephaly (HP:0004481)2.07060179
116Lethargy (HP:0001254)2.05315370
117Mixed hearing impairment (HP:0000410)2.04235038
118Onycholysis (HP:0001806)2.04059490
119Myocardial infarction (HP:0001658)2.03954543
120Concave nail (HP:0001598)2.03510703
121Skin nodule (HP:0200036)2.01786087
122Mesangial abnormality (HP:0001966)2.01595510
123Hyperventilation (HP:0002883)2.00950078
124Hypertriglyceridemia (HP:0002155)2.00701101
125Duplicated collecting system (HP:0000081)2.00131160
126Polyuria (HP:0000103)2.00099856
127Methylmalonic acidemia (HP:0002912)1.99824217
128Aplasia/Hypoplasia of the spleen (HP:0010451)1.98512675
129Irritability (HP:0000737)1.98211662
130Hyperbilirubinemia (HP:0002904)1.97506417
131Esophageal varix (HP:0002040)1.97296847
132Abnormal mitochondria in muscle tissue (HP:0008316)1.97129595
133Pachygyria (HP:0001302)1.97063541
134Hepatocellular necrosis (HP:0001404)1.95632836
135Thyroid-stimulating hormone excess (HP:0002925)1.95245138
136Abnormality of the renal collecting system (HP:0004742)1.94702151
137Bronchomalacia (HP:0002780)1.94674509
138Optic disc pallor (HP:0000543)1.94429468
139Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.94143053
140Fat malabsorption (HP:0002630)1.93786329
141Asplenia (HP:0001746)1.93512536
142Abnormality of dicarboxylic acid metabolism (HP:0010995)1.93116207
143Dicarboxylic aciduria (HP:0003215)1.93116207
144Split foot (HP:0001839)1.92348271
145Turricephaly (HP:0000262)1.91603298
146Hepatic necrosis (HP:0002605)1.90524936
147Decreased central vision (HP:0007663)1.90371096
148Abnormality of nail color (HP:0100643)1.90071483
149Prenatal maternal abnormality (HP:0002686)1.89905125
150Lipid accumulation in hepatocytes (HP:0006561)1.89481774
151Cholecystitis (HP:0001082)1.88969857
152Abnormal gallbladder physiology (HP:0012438)1.88969857
153Abnormality of nucleobase metabolism (HP:0010932)1.87755855
154Furrowed tongue (HP:0000221)1.87578659
155Hypoplasia of the fovea (HP:0007750)1.87488738
156Aplasia/Hypoplasia of the fovea (HP:0008060)1.87488738
157Retinal dysplasia (HP:0007973)1.87326079
158Short hallux (HP:0010109)1.87128979
159Bifid scrotum (HP:0000048)1.86630666
160Postaxial foot polydactyly (HP:0001830)1.83329386
161Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.83225993
162Stage 5 chronic kidney disease (HP:0003774)1.82506956
163Narrow forehead (HP:0000341)1.82397147
164Mitral stenosis (HP:0001718)1.82330700
165Disproportionate short-trunk short stature (HP:0003521)1.81443540
166Sclerocornea (HP:0000647)1.81255176
167Abnormality of the pons (HP:0007361)1.80870715
168Male pseudohermaphroditism (HP:0000037)1.79736890
169Optic nerve hypoplasia (HP:0000609)1.78058412
170Increased neuronal autofluorescent lipopigment (HP:0002074)1.77983078
171Gait imbalance (HP:0002141)1.77645100
172Hemiparesis (HP:0001269)1.77573518
1733-Methylglutaconic aciduria (HP:0003535)1.77456503
174Patellar aplasia (HP:0006443)1.76495200
175Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.76434589
176Anterior segment dysgenesis (HP:0007700)1.74884023
177Decreased electroretinogram (ERG) amplitude (HP:0000654)1.72905485
178Global brain atrophy (HP:0002283)1.72470306
179Aplasia/Hypoplasia of the patella (HP:0006498)1.72435153
180Thyroiditis (HP:0100646)1.72171471
181Aplasia/Hypoplasia of the hallux (HP:0008362)1.71928753
182Heart block (HP:0012722)1.71927759
183Gaze-evoked nystagmus (HP:0000640)1.71862266
184Abnormal biliary tract physiology (HP:0012439)1.71552691
185Bile duct proliferation (HP:0001408)1.71552691
186Increased hepatocellular lipid droplets (HP:0006565)1.71024592
187Abnormal urine output (HP:0012590)1.70750148

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA46.82318305
2LMTK24.98938675
3FRK4.67310385
4TRIB34.28713564
5SIK13.79134358
6ADRBK23.71128834
7PHKG13.70996912
8PHKG23.70996912
9MAP4K23.54253315
10BCKDK3.26550305
11NTRK23.13334721
12GRK13.07460746
13WNK42.81662382
14WNK32.52376372
15BMPR1B2.28854574
16TLK12.24230673
17TXK2.23272821
18MUSK2.22899512
19TAOK32.06059818
20TNIK1.99213725
21MAPK121.91748346
22PINK11.91542882
23DAPK21.78831513
24IRAK31.70576897
25TESK21.69859549
26NTRK31.66032522
27NUAK11.58299116
28ACVR1B1.51219980
29ERN11.46782674
30GRK61.43682256
31MAP2K41.43309048
32FGFR21.42361534
33NTRK11.42211790
34MAPK71.37743374
35PRKCG1.33832834
36ZAK1.29108355
37SGK21.23259863
38MKNK21.13349873
39FGR1.12544680
40KSR21.10526245
41SGK4941.08063345
42SGK2231.08063345
43DYRK1A1.08058870
44MINK11.07629977
45CSNK1G21.06907979
46INSRR1.05881123
47SGK31.02224101
48ERBB41.01674592
49CSNK1G31.01354068
50ERBB31.00814789
51DYRK20.98431119
52FGFR10.96848395
53STK390.96023967
54PRKD30.93345264
55MKNK10.90713937
56PKN20.89530553
57CSNK1G10.89518913
58AKT30.85545971
59KIT0.84983528
60MAP3K40.84763291
61FGFR40.84013228
62MAP2K70.82444714
63MAPKAPK30.81995200
64KSR10.81980785
65TRIM280.81744472
66TGFBR10.79157930
67CDK50.79108696
68PLK20.77605032
69STK38L0.75980889
70CAMKK20.75655814
71CAMK2G0.74679748
72TIE10.72763262
73PRKAA20.72727336
74CSNK1A1L0.71017795
75BMX0.70653985
76SIK20.70648621
77PRKCE0.69601716
78PDPK10.69454633
79SRPK10.68392005
80BCR0.68207008
81MAPKAPK50.67809831
82GRK50.67741116
83PAK30.67722095
84PIK3CA0.67398924
85MAP2K60.67153812
86CASK0.66907787
87PRKCH0.66195734
88SIK30.65473844
89MAPK40.65016570
90CAMK2A0.64666142
91PAK60.64467761
92PRKD20.63918416
93PDK20.62760526
94VRK20.62288948
95PRKACG0.61633292
96PRKCI0.60991297
97MAPK110.60316078
98VRK10.57941886
99AKT20.57878722
100PRKCQ0.56534630
101PTK2B0.55717851
102PDK10.55545469
103IGF1R0.55489988
104MAP2K10.55069813
105MYLK0.52387142
106ADRBK10.50850226
107CAMKK10.50734237
108PRKCA0.50353385
109MAP3K70.49493026
110ERBB20.48343443
111TAOK20.47670678
112OXSR10.47266036
113STK380.46912889
114PTK60.46332775
115PRKCZ0.46163325
116IKBKB0.45753306
117NEK60.44486018
118CAMK10.44226715
119JAK30.43170031
120MAP3K130.42880381
121RPS6KA30.41362143
122MAP3K90.41204885
123ABL20.40862783
124SGK10.40270604
125MAP3K20.38879517
126FLT30.38519705
127PRKACA0.38155659
128MARK30.37998701
129TGFBR20.37189939
130MET0.37044736
131JAK20.36038057
132PKN10.35551500
133GRK70.33692310
134LRRK20.31600888
135TYRO30.31391846
136SRC0.31282713
137MAPK130.30024638
138STK30.29647542
139ABL10.29171188
140RET0.27737661
141PRKACB0.27652410
142CAMK2B0.27601481
143PRKCB0.27221828
144ROCK10.27071728
145PRKAA10.26842131
146EPHB20.25326343
147PDGFRA0.24326911
148PIK3CG0.23372842
149ICK0.21854835
150MARK10.21099326
151EGFR0.20698395
152CSNK1A10.19326136
153PRKG10.19070178
154CDK150.17142028

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009105.54935927
2Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010403.44124361
3Primary bile acid biosynthesis_Homo sapiens_hsa001203.17754135
4Fatty acid degradation_Homo sapiens_hsa000713.08557979
5Arginine biosynthesis_Homo sapiens_hsa002202.97722271
6Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.92821223
7Fatty acid biosynthesis_Homo sapiens_hsa000612.74512543
8Fatty acid metabolism_Homo sapiens_hsa012122.73012296
9Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.45886214
10Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.41043298
11Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.34382368
12Linoleic acid metabolism_Homo sapiens_hsa005912.32269682
13Propanoate metabolism_Homo sapiens_hsa006402.23024086
14Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.19614084
15PPAR signaling pathway_Homo sapiens_hsa033202.19402303
16Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.09019826
17Complement and coagulation cascades_Homo sapiens_hsa046102.03458933
18Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002502.01721883
19Peroxisome_Homo sapiens_hsa041461.96214870
20Phototransduction_Homo sapiens_hsa047441.92359771
21Tryptophan metabolism_Homo sapiens_hsa003801.92054919
222-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.91107474
23Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.89845602
24Butanoate metabolism_Homo sapiens_hsa006501.80177479
25Steroid biosynthesis_Homo sapiens_hsa001001.76343248
26Oxidative phosphorylation_Homo sapiens_hsa001901.73767541
27Biosynthesis of amino acids_Homo sapiens_hsa012301.72500959
28Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.54875967
29Fatty acid elongation_Homo sapiens_hsa000621.54097177
30Sulfur relay system_Homo sapiens_hsa041221.48949483
31Cysteine and methionine metabolism_Homo sapiens_hsa002701.47992486
32Bile secretion_Homo sapiens_hsa049761.46299588
33Pentose and glucuronate interconversions_Homo sapiens_hsa000401.42105665
34Protein export_Homo sapiens_hsa030601.40942379
35Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.33163680
36beta-Alanine metabolism_Homo sapiens_hsa004101.32561520
37Pyruvate metabolism_Homo sapiens_hsa006201.31174596
38Parkinsons disease_Homo sapiens_hsa050121.30665717
39Carbon metabolism_Homo sapiens_hsa012001.30029611
40Phenylalanine metabolism_Homo sapiens_hsa003601.28840519
41Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.28440978
42Arginine and proline metabolism_Homo sapiens_hsa003301.26437534
43Chemical carcinogenesis_Homo sapiens_hsa052041.21088924
44Starch and sucrose metabolism_Homo sapiens_hsa005001.20321287
45Histidine metabolism_Homo sapiens_hsa003401.19634430
46Arachidonic acid metabolism_Homo sapiens_hsa005901.13329394
47Sulfur metabolism_Homo sapiens_hsa009201.12272581
48Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.08360761
49Steroid hormone biosynthesis_Homo sapiens_hsa001401.06445492
50Tyrosine metabolism_Homo sapiens_hsa003501.03342281
51Intestinal immune network for IgA production_Homo sapiens_hsa046721.03288079
52Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.03023306
53Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.02808485
54Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.02221303
55Basal transcription factors_Homo sapiens_hsa030221.00267756
56Taste transduction_Homo sapiens_hsa047420.99171496
57Retinol metabolism_Homo sapiens_hsa008300.97799083
58Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.96110387
59Vitamin B6 metabolism_Homo sapiens_hsa007500.95138809
60Cardiac muscle contraction_Homo sapiens_hsa042600.94805864
61Caffeine metabolism_Homo sapiens_hsa002320.93388778
62Vitamin digestion and absorption_Homo sapiens_hsa049770.92912312
63Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.92046151
64Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.90704701
65Glycerolipid metabolism_Homo sapiens_hsa005610.85554048
66Staphylococcus aureus infection_Homo sapiens_hsa051500.85132146
67Drug metabolism - other enzymes_Homo sapiens_hsa009830.83816175
68Proteasome_Homo sapiens_hsa030500.82704102
69Selenocompound metabolism_Homo sapiens_hsa004500.82555324
70Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.80982832
71RNA polymerase_Homo sapiens_hsa030200.80888566
72Fanconi anemia pathway_Homo sapiens_hsa034600.79570763
73ABC transporters_Homo sapiens_hsa020100.78714465
74Homologous recombination_Homo sapiens_hsa034400.77216036
75Pentose phosphate pathway_Homo sapiens_hsa000300.76572821
76Alzheimers disease_Homo sapiens_hsa050100.72147397
77Ovarian steroidogenesis_Homo sapiens_hsa049130.71596000
78Fat digestion and absorption_Homo sapiens_hsa049750.70032321
79Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.68683668
80Fructose and mannose metabolism_Homo sapiens_hsa000510.68046018
81Cyanoamino acid metabolism_Homo sapiens_hsa004600.64909358
82Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.64338035
83Folate biosynthesis_Homo sapiens_hsa007900.62485210
84Adipocytokine signaling pathway_Homo sapiens_hsa049200.62319186
85Olfactory transduction_Homo sapiens_hsa047400.61781223
86Hedgehog signaling pathway_Homo sapiens_hsa043400.60827516
87Circadian rhythm_Homo sapiens_hsa047100.59116483
88Huntingtons disease_Homo sapiens_hsa050160.58821360
89Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.57726141
90Lysine degradation_Homo sapiens_hsa003100.55503674
91Collecting duct acid secretion_Homo sapiens_hsa049660.55113782
92RNA degradation_Homo sapiens_hsa030180.51795083
93Regulation of autophagy_Homo sapiens_hsa041400.49845457
94Metabolic pathways_Homo sapiens_hsa011000.45750222
95Nicotine addiction_Homo sapiens_hsa050330.45088094
96Glucagon signaling pathway_Homo sapiens_hsa049220.43853308
97Primary immunodeficiency_Homo sapiens_hsa053400.42994850
98Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.42155845
99Galactose metabolism_Homo sapiens_hsa000520.41850720
100Glycerophospholipid metabolism_Homo sapiens_hsa005640.41429468
101Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.41002365
102Asthma_Homo sapiens_hsa053100.40243648
103Basal cell carcinoma_Homo sapiens_hsa052170.37978667
104GABAergic synapse_Homo sapiens_hsa047270.37486892
105Glutamatergic synapse_Homo sapiens_hsa047240.35231098
106Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.33452188
107alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.32887899
108Cocaine addiction_Homo sapiens_hsa050300.31642130
109One carbon pool by folate_Homo sapiens_hsa006700.31204678
110Glutathione metabolism_Homo sapiens_hsa004800.30327539
111Insulin resistance_Homo sapiens_hsa049310.26910863
112Prion diseases_Homo sapiens_hsa050200.18734391
113African trypanosomiasis_Homo sapiens_hsa051430.17208941
114Insulin secretion_Homo sapiens_hsa049110.17056717
115Maturity onset diabetes of the young_Homo sapiens_hsa049500.16421960
116Glycosaminoglycan degradation_Homo sapiens_hsa005310.14904892
117Carbohydrate digestion and absorption_Homo sapiens_hsa049730.12350459
118Salivary secretion_Homo sapiens_hsa049700.10977004
119Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.09420902
120Mineral absorption_Homo sapiens_hsa049780.08197903
121Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.06519897
122Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.05390727
123Dorso-ventral axis formation_Homo sapiens_hsa043200.04536065
124Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.03921383
125AMPK signaling pathway_Homo sapiens_hsa041520.03365872
126Morphine addiction_Homo sapiens_hsa050320.02914103
127Ether lipid metabolism_Homo sapiens_hsa005650.02826611
128Malaria_Homo sapiens_hsa051440.02434237
129Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.00089399
130Gastric acid secretion_Homo sapiens_hsa04971-0.0024593
131Circadian entrainment_Homo sapiens_hsa04713-0.0024076

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