PPP1R42

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene can interact with gamma-tubulin and PP1 phosphatase, a regulator of centrosome separation. The encoded protein is a positive regulator of PP1 phosphatase and thus plays a role in the control of centrosome integrity. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1binding of sperm to zona pellucida (GO:0007339)9.90471000
2acrosome reaction (GO:0007340)9.82028207
3cilium movement (GO:0003341)9.35663247
4motile cilium assembly (GO:0044458)9.01304938
5spermatid development (GO:0007286)8.59151288
6epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)8.33478163
7sperm capacitation (GO:0048240)8.11335416
8single fertilization (GO:0007338)7.65974417
9male meiosis (GO:0007140)7.56063786
10regulation of cilium movement (GO:0003352)7.46041482
11synaptonemal complex organization (GO:0070193)6.85862782
12synaptonemal complex assembly (GO:0007130)6.73425700
13piRNA metabolic process (GO:0034587)6.73130677
14spermatid nucleus differentiation (GO:0007289)6.50691542
15fertilization (GO:0009566)6.12105622
16negative regulation of inclusion body assembly (GO:0090084)5.64774927
17ventricular system development (GO:0021591)5.50025008
18spermatogenesis (GO:0007283)5.38224592
19male gamete generation (GO:0048232)5.36000699
20organic cation transport (GO:0015695)5.06054447
21calcium ion-dependent exocytosis (GO:0017156)5.03407224
22microtubule severing (GO:0051013)4.99447132
23gamete generation (GO:0007276)4.94966122
24cell recognition (GO:0008037)4.93492092
25regulation of inclusion body assembly (GO:0090083)4.91685606
26cellular process involved in reproduction in multicellular organism (GO:0022412)4.88215838
27germ cell development (GO:0007281)4.69071486
28chromosome organization involved in meiosis (GO:0070192)4.61229834
29microtubule depolymerization (GO:0007019)4.56471416
30neuron fate determination (GO:0048664)4.37800755
31regulation of microtubule-based movement (GO:0060632)4.35745975
32sexual reproduction (GO:0019953)4.31180845
33DNA methylation involved in gamete generation (GO:0043046)4.24797936
34axoneme assembly (GO:0035082)4.19956108
35protein localization to cilium (GO:0061512)4.12005362
36glycerol ether metabolic process (GO:0006662)4.11839634
37male meiosis I (GO:0007141)4.03837106
38protein polyglutamylation (GO:0018095)4.03788242
39meiotic nuclear division (GO:0007126)4.03581234
40lactate metabolic process (GO:0006089)4.03437903
41intraciliary transport (GO:0042073)3.93978528
42monoubiquitinated protein deubiquitination (GO:0035520)3.89768761
43smoothened signaling pathway (GO:0007224)3.89453892
44multicellular organismal reproductive process (GO:0048609)3.87870080
45single strand break repair (GO:0000012)3.82128419
46ether metabolic process (GO:0018904)3.79130205
47cilium organization (GO:0044782)3.79110304
48determination of left/right symmetry (GO:0007368)3.76612590
49protein K11-linked deubiquitination (GO:0035871)3.76242966
50cilium assembly (GO:0042384)3.63828087
51determination of bilateral symmetry (GO:0009855)3.54994966
52neuronal stem cell maintenance (GO:0097150)3.52370665
53microtubule bundle formation (GO:0001578)3.49501893
54left/right pattern formation (GO:0060972)3.49276446
55specification of symmetry (GO:0009799)3.48245071
56genitalia morphogenesis (GO:0035112)3.42694367
57cell projection assembly (GO:0030031)3.40947275
58cellular component assembly involved in morphogenesis (GO:0010927)3.40491986
59seminiferous tubule development (GO:0072520)3.34692315
60negative regulation of oligodendrocyte differentiation (GO:0048715)3.33749438
61telencephalon development (GO:0021537)3.32576364
62mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.31762750
63glycolytic process (GO:0006096)3.31246546
64microtubule-based movement (GO:0007018)3.28076835
65nonmotile primary cilium assembly (GO:0035058)3.22847662
66limb bud formation (GO:0060174)3.19798423
67meiosis I (GO:0007127)3.14388221
68neural tube formation (GO:0001841)3.12072686
69multicellular organismal development (GO:0007275)3.11371430
70cilium morphogenesis (GO:0060271)3.08157543
71otic vesicle formation (GO:0030916)3.06249554
72substrate-independent telencephalic tangential migration (GO:0021826)3.04641198
73substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.04641198
74retinal rod cell development (GO:0046548)3.01945379
75polyol catabolic process (GO:0046174)3.01161730
76mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.98034731
77meiotic cell cycle (GO:0051321)2.97506733
78chaperone-mediated protein complex assembly (GO:0051131)2.97213943
79GTP biosynthetic process (GO:0006183)2.96340209
80regulation of secondary heart field cardioblast proliferation (GO:0003266)2.95963206
81regulation of cardioblast proliferation (GO:0003264)2.95963206
82nucleoside diphosphate phosphorylation (GO:0006165)2.95469049
83dopamine transport (GO:0015872)2.94368801
84transmission of nerve impulse (GO:0019226)2.93583243
85photoreceptor cell maintenance (GO:0045494)2.92648837
86radial glial cell differentiation (GO:0060019)2.92563871
87centriole assembly (GO:0098534)2.92486102
88establishment of protein localization to mitochondrial membrane (GO:0090151)2.89761824
89left/right axis specification (GO:0070986)2.89731585
90regulation of timing of cell differentiation (GO:0048505)2.87099976
91nephron epithelium morphogenesis (GO:0072088)2.85966091
92nephron tubule morphogenesis (GO:0072078)2.85966091
93calcium ion import (GO:0070509)2.84853434
94spinal cord motor neuron differentiation (GO:0021522)2.83143874
95centriole replication (GO:0007099)2.82193549
96alditol metabolic process (GO:0019400)2.79492849
97cell proliferation in forebrain (GO:0021846)2.78296484
98negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)2.77964533
99synapsis (GO:0007129)2.76994746
100intra-S DNA damage checkpoint (GO:0031573)2.75304465
101cochlea development (GO:0090102)2.73235326
102negative regulation of organelle assembly (GO:1902116)2.68929362
103amino-acid betaine transport (GO:0015838)2.67479438
104carnitine transport (GO:0015879)2.67479438
105prepulse inhibition (GO:0060134)2.67470402
106peristalsis (GO:0030432)2.65940918
107cell morphogenesis involved in neuron differentiation (GO:0048667)2.64631505
108negative regulation of axon guidance (GO:1902668)2.64338944
109peptidyl-glutamic acid modification (GO:0018200)2.64100642
110retinal ganglion cell axon guidance (GO:0031290)2.62995342
111energy coupled proton transport, down electrochemical gradient (GO:0015985)2.62879663
112ATP synthesis coupled proton transport (GO:0015986)2.62879663
113glycerol metabolic process (GO:0006071)2.62360652
114carnitine transmembrane transport (GO:1902603)2.62011467
115chromosome condensation (GO:0030261)2.60487324
116sequestering of actin monomers (GO:0042989)2.57887165
117regulation of development, heterochronic (GO:0040034)2.56681857
118auditory behavior (GO:0031223)2.55995751
119lateral ventricle development (GO:0021670)2.55603534
120UTP biosynthetic process (GO:0006228)2.54334070
121glutathione derivative biosynthetic process (GO:1901687)2.53130614
122glutathione derivative metabolic process (GO:1901685)2.53130614
123protein refolding (GO:0042026)2.52391762
124electron transport chain (GO:0022900)2.51063605
125behavioral response to cocaine (GO:0048148)2.49618774
126retinal cone cell development (GO:0046549)2.47366280
127macroautophagy (GO:0016236)2.47250778
128meiotic cell cycle process (GO:1903046)2.45436990
129nucleus organization (GO:0006997)2.43660572
130inner ear receptor stereocilium organization (GO:0060122)2.43383398
131detection of light stimulus involved in visual perception (GO:0050908)2.43267033
132detection of light stimulus involved in sensory perception (GO:0050962)2.43267033
133respiratory electron transport chain (GO:0022904)2.42222763
134presynaptic membrane organization (GO:0097090)2.41656891
135regulation of podosome assembly (GO:0071801)2.40898281
136regulation of cytokine production involved in inflammatory response (GO:1900015)2.40887211
137DNA packaging (GO:0006323)2.39729728
138tongue development (GO:0043586)2.39270680
139lateral sprouting from an epithelium (GO:0060601)2.39105776
140photoreceptor cell development (GO:0042461)2.38350770
141regulation of neurotransmitter uptake (GO:0051580)2.38251258
142behavioral response to nicotine (GO:0035095)2.37618551
143UTP metabolic process (GO:0046051)2.35945346
144regulation of centriole replication (GO:0046599)2.35776080
145regulation of cell proliferation involved in heart morphogenesis (GO:2000136)2.34789863
146striatum development (GO:0021756)2.32518368
147negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.31438449
148membrane repolarization during action potential (GO:0086011)2.31392773
149regulation of collateral sprouting (GO:0048670)2.30300955
150establishment of tissue polarity (GO:0007164)2.29574311
151establishment of planar polarity (GO:0001736)2.29574311
152purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.28487009
153negative regulation of epidermal cell differentiation (GO:0045605)2.27535130
154establishment of nucleus localization (GO:0040023)2.27411795
155detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.26716746
156somite development (GO:0061053)2.25911630
157axon ensheathment in central nervous system (GO:0032291)2.25602391
158cell wall macromolecule metabolic process (GO:0044036)14.3630822
159cell wall macromolecule catabolic process (GO:0016998)14.3630822
160fusion of sperm to egg plasma membrane (GO:0007342)13.3521650
161cilium or flagellum-dependent cell motility (GO:0001539)12.3578419
162sperm motility (GO:0030317)12.2790011
163acrosome assembly (GO:0001675)12.1903483
164multicellular organism reproduction (GO:0032504)11.7265776
165sperm-egg recognition (GO:0035036)11.2426170
166epithelial cilium movement (GO:0003351)10.4847525
167axonemal dynein complex assembly (GO:0070286)10.4617081
168plasma membrane fusion (GO:0045026)10.1725921
169cell-cell recognition (GO:0009988)10.0990649
170reproduction (GO:0000003)10.0788511

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse7.65797476
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse5.02009294
3BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.91460319
4EZH2_22144423_ChIP-Seq_EOC_Human3.39044783
5GBX2_23144817_ChIP-Seq_PC3_Human3.12000466
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.90624778
7FLI1_27457419_Chip-Seq_LIVER_Mouse2.59476296
8PCGF2_27294783_Chip-Seq_ESCs_Mouse2.48540323
9CBX2_27304074_Chip-Seq_ESCs_Mouse2.44951076
10FUS_26573619_Chip-Seq_HEK293_Human2.44813170
11ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.44680145
12PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.42504396
13POU3F2_20337985_ChIP-ChIP_501MEL_Human2.31590355
14HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.30483705
15PIAS1_25552417_ChIP-Seq_VCAP_Human2.25346065
16CTBP1_25329375_ChIP-Seq_LNCAP_Human2.16030006
17IGF1R_20145208_ChIP-Seq_DFB_Human2.11955338
18GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.06045090
19EWS_26573619_Chip-Seq_HEK293_Human2.05316409
20KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse2.03382146
21P300_19829295_ChIP-Seq_ESCs_Human2.02178264
22VDR_22108803_ChIP-Seq_LS180_Human1.99788790
23PCGF2_27294783_Chip-Seq_NPCs_Mouse1.99558742
24CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.98394417
25RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.95478017
26ZFP57_27257070_Chip-Seq_ESCs_Mouse1.94222660
27E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.94004814
28EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.92870712
29KAP1_22055183_ChIP-Seq_ESCs_Mouse1.87553548
30SUZ12_27294783_Chip-Seq_NPCs_Mouse1.84229853
31TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.82571817
32NFE2_27457419_Chip-Seq_LIVER_Mouse1.78812125
33GATA1_26923725_Chip-Seq_HPCs_Mouse1.77157268
34CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.77063807
35TOP2B_26459242_ChIP-Seq_MCF-7_Human1.75758402
36KDM2B_26808549_Chip-Seq_REH_Human1.75727844
37SMAD4_21799915_ChIP-Seq_A2780_Human1.73778332
38FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.73098476
39TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.72008797
40BCAT_22108803_ChIP-Seq_LS180_Human1.71609424
41TAL1_26923725_Chip-Seq_HPCs_Mouse1.70468322
42ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.69908047
43PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.66686373
44STAT1_17558387_ChIP-Seq_HELA_Human1.63966162
45SMAD3_21741376_ChIP-Seq_EPCs_Human1.62450425
46AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.61674268
47EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.61200540
48CTBP2_25329375_ChIP-Seq_LNCAP_Human1.58924747
49NANOG_18555785_Chip-Seq_ESCs_Mouse1.57655665
50NR3C1_21868756_ChIP-Seq_MCF10A_Human1.57307171
51ELK4_26923725_Chip-Seq_MESODERM_Mouse1.54224581
52GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.53682249
53CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.52644054
54HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.52156786
55ZNF274_21170338_ChIP-Seq_K562_Hela1.51270211
56FLI1_21867929_ChIP-Seq_TH2_Mouse1.49078527
57STAT3_23295773_ChIP-Seq_U87_Human1.47972319
58CBP_20019798_ChIP-Seq_JUKART_Human1.47703038
59IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.47703038
60MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.47618623
61SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.47236209
62AR_21572438_ChIP-Seq_LNCaP_Human1.45413862
63P53_22387025_ChIP-Seq_ESCs_Mouse1.45329923
64MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.44982735
65UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.44725012
66CMYC_18555785_Chip-Seq_ESCs_Mouse1.44710307
67AR_25329375_ChIP-Seq_VCAP_Human1.44596108
68CRX_20693478_ChIP-Seq_RETINA_Mouse1.44251575
69OCT4_18555785_Chip-Seq_ESCs_Mouse1.44250879
70STAT6_21828071_ChIP-Seq_BEAS2B_Human1.42874696
71TCF4_22108803_ChIP-Seq_LS180_Human1.42008181
72REST_21632747_ChIP-Seq_MESCs_Mouse1.39564877
73EZH2_27294783_Chip-Seq_NPCs_Mouse1.39132182
74P300_18555785_Chip-Seq_ESCs_Mouse1.39121643
75EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.38484751
76MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.38099355
77GATA3_21867929_ChIP-Seq_CD8_Mouse1.37275413
78SUZ12_18555785_Chip-Seq_ESCs_Mouse1.37266323
79GABP_17652178_ChIP-ChIP_JURKAT_Human1.37214254
80TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.35819502
81TCF4_23295773_ChIP-Seq_U87_Human1.35410632
82RUNX2_22187159_ChIP-Seq_PCA_Human1.35007498
83CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.34051360
84WDR5_24793694_ChIP-Seq_LNCAP_Human1.32801571
85GATA3_21867929_ChIP-Seq_TH1_Mouse1.32611054
86RNF2_27304074_Chip-Seq_NSC_Mouse1.32432347
87RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.32366884
88KLF4_18555785_Chip-Seq_ESCs_Mouse1.32341479
89BMI1_23680149_ChIP-Seq_NPCS_Mouse1.31504897
90ESRRB_18555785_Chip-Seq_ESCs_Mouse1.31043530
91OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.30984600
92STAT3_18555785_Chip-Seq_ESCs_Mouse1.30873329
93EED_16625203_ChIP-ChIP_MESCs_Mouse1.28311277
94TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.27410365
95OCT4_21477851_ChIP-Seq_ESCs_Mouse1.25848692
96PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.25285398
97SOX2_18555785_Chip-Seq_ESCs_Mouse1.24707407
98CTCF_18555785_Chip-Seq_ESCs_Mouse1.23475193
99SOX2_22085726_ChIP-Seq_NPCs_Mouse1.22338868
100RUNX1_27457419_Chip-Seq_LIVER_Mouse1.22074683
101E2F1_18555785_Chip-Seq_ESCs_Mouse1.21789119
102POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.20027813
103TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20027813
104SMAD1_18555785_Chip-Seq_ESCs_Mouse1.19374802
105POU5F1_16153702_ChIP-ChIP_HESCs_Human1.19061061
106GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.18437753
107PU1_27457419_Chip-Seq_LIVER_Mouse1.18221302
108FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.17999983
109LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.17831203
110NANOG_19829295_ChIP-Seq_ESCs_Human1.17551056
111SOX2_19829295_ChIP-Seq_ESCs_Human1.17551056
112FOXA1_27270436_Chip-Seq_PROSTATE_Human1.16534205
113FOXA1_25329375_ChIP-Seq_VCAP_Human1.16534205
114GF1_26923725_Chip-Seq_HPCs_Mouse1.14791585
115FOXM1_26456572_ChIP-Seq_MCF-7_Human1.13916202
116FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.13545722
117CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.13504496
118NMYC_18555785_Chip-Seq_ESCs_Mouse1.12353905
119TBL1_22424771_ChIP-Seq_293T_Human1.11060104
120SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.10274494
121CDX2_22108803_ChIP-Seq_LS180_Human1.08383779
122SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.08174231
123PHF8_20622853_ChIP-Seq_HELA_Human1.07947862
124ZFX_18555785_Chip-Seq_ESCs_Mouse1.07334996
125SOX2_21211035_ChIP-Seq_LN229_Gbm1.05579723
126TAF15_26573619_Chip-Seq_HEK293_Human1.05551574
127EZH2_27304074_Chip-Seq_ESCs_Mouse1.05248385
128KLF5_20875108_ChIP-Seq_MESCs_Mouse1.04980312
129PRDM14_20953172_ChIP-Seq_ESCs_Human1.04646661
130LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04617671
131SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.03910821
132P53_21459846_ChIP-Seq_SAOS-2_Human1.03696411
133SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.03338453
134RUNX1_26923725_Chip-Seq_HPCs_Mouse1.02498831
135JUN_21703547_ChIP-Seq_K562_Human1.01652937
136TP53_18474530_ChIP-ChIP_U2OS_Human1.01609730
137EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.01497155
138ARNT_22903824_ChIP-Seq_MCF-7_Human1.00663475
139SPI1_26923725_Chip-Seq_HPCs_Mouse1.00165238
140GF1B_26923725_Chip-Seq_HPCs_Mouse0.99472670
141P53_22127205_ChIP-Seq_FIBROBLAST_Human0.98623583
142SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.98471858
143DROSHA_22980978_ChIP-Seq_HELA_Human0.98446223
144AHR_22903824_ChIP-Seq_MCF-7_Human0.98233313
145JARID2_20064375_ChIP-Seq_MESCs_Mouse0.97062575
146NFYA_21822215_ChIP-Seq_K562_Human0.96800852
147IRF1_19129219_ChIP-ChIP_H3396_Human0.96527923
148NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.96341180
149SOX9_26525672_Chip-Seq_HEART_Mouse0.94587148
150SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.94318788
151PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.94038179
152SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.93978897
153ER_23166858_ChIP-Seq_MCF-7_Human0.92864736
154CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.91838086
155CDX2_19796622_ChIP-Seq_MESCs_Mouse0.91654080
156EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.89741300
157NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.89100858
158ESET_19884257_ChIP-Seq_ESCs_Mouse0.88704156
159CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87754745
160SMAD4_21741376_ChIP-Seq_EPCs_Human0.87466086
161NFYB_21822215_ChIP-Seq_K562_Human0.87092824
162ERG_20517297_ChIP-Seq_VCAP_Human0.86998352
163SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.86735614

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive5.57288285
2MP0003136_yellow_coat_color5.42175469
3MP0001929_abnormal_gametogenesis5.00215730
4MP0003880_abnormal_central_pattern4.32850606
5MP0008877_abnormal_DNA_methylation3.88547695
6MP0002653_abnormal_ependyma_morphology3.61671287
7MP0005551_abnormal_eye_electrophysiolog3.34954371
8MP0003011_delayed_dark_adaptation3.27135145
9MP0002210_abnormal_sex_determination3.11736384
10MP0002161_abnormal_fertility/fecundity2.93639302
11MP0001984_abnormal_olfaction2.86521521
12MP0001145_abnormal_male_reproductive2.69513335
13MP0006072_abnormal_retinal_apoptosis2.49548696
14MP0003878_abnormal_ear_physiology2.38911119
15MP0005377_hearing/vestibular/ear_phenot2.38911119
16MP0000653_abnormal_sex_gland2.37997286
17MP0005253_abnormal_eye_physiology2.36260993
18MP0001485_abnormal_pinna_reflex2.29662990
19MP0005171_absent_coat_pigmentation2.25799272
20MP0003283_abnormal_digestive_organ2.05458580
21MP0000566_synostosis2.05163171
22MP0005623_abnormal_meninges_morphology2.00626723
23MP0005410_abnormal_fertilization14.1141153
24MP0003950_abnormal_plasma_membrane1.96744840
25MP0008789_abnormal_olfactory_epithelium1.94679700
26MP0005670_abnormal_white_adipose1.92953973
27MP0002277_abnormal_respiratory_mucosa1.89000071
28MP0000026_abnormal_inner_ear1.76243396
29MP0001529_abnormal_vocalization1.73074403
30MP0002938_white_spotting1.70176135
31MP0009046_muscle_twitch1.69459563
32MP0000778_abnormal_nervous_system1.55235958
33MP0002822_catalepsy1.51971981
34MP0002928_abnormal_bile_duct1.49461365
35MP0000372_irregular_coat_pigmentation1.46083184
36MP0005394_taste/olfaction_phenotype1.43438186
37MP0005499_abnormal_olfactory_system1.43438186
38MP0002282_abnormal_trachea_morphology1.40877828
39MP0003806_abnormal_nucleotide_metabolis1.36576266
40MP0001293_anophthalmia1.35504872
41MP0001765_abnormal_ion_homeostasis1.31090026
42MP0004142_abnormal_muscle_tone1.30039802
43MP0001764_abnormal_homeostasis1.29596543
44MP0001324_abnormal_eye_pigmentation1.25533983
45MP0009745_abnormal_behavioral_response1.24815031
46MP0005195_abnormal_posterior_eye1.23342172
47MP0000383_abnormal_hair_follicle1.22764075
48MP0005391_vision/eye_phenotype1.22097916
49MP0003938_abnormal_ear_development1.21219799
50MP0002638_abnormal_pupillary_reflex1.19543480
51MP0004233_abnormal_muscle_weight1.18809649
52MP0002734_abnormal_mechanical_nocicepti1.18466078
53MP0008058_abnormal_DNA_repair1.17265506
54MP0006292_abnormal_olfactory_placode1.16441859
55MP0005360_urolithiasis1.15902742
56MP0005174_abnormal_tail_pigmentation1.13589403
57MP0004019_abnormal_vitamin_homeostasis1.09266047
58MP0002160_abnormal_reproductive_system1.08154891
59MP0002751_abnormal_autonomic_nervous1.08129760
60MP0000955_abnormal_spinal_cord1.07731450
61MP0002837_dystrophic_cardiac_calcinosis1.06585753
62MP0002249_abnormal_larynx_morphology1.06248360
63MP0006276_abnormal_autonomic_nervous1.05780458
64MP0004885_abnormal_endolymph1.05229249
65MP0002233_abnormal_nose_morphology1.04993226
66MP0003937_abnormal_limbs/digits/tail_de1.02509648
67MP0002557_abnormal_social/conspecific_i1.00751859
68MP0002139_abnormal_hepatobiliary_system1.00443270
69MP0001286_abnormal_eye_development0.99897973
70MP0002095_abnormal_skin_pigmentation0.99435295
71MP0004145_abnormal_muscle_electrophysio0.99098141
72MP0003122_maternal_imprinting0.98482484
73MP0000049_abnormal_middle_ear0.97129902
74MP0004742_abnormal_vestibular_system0.94363247
75MP0002064_seizures0.93389349
76MP0005647_abnormal_sex_gland0.90767905
77MP0002229_neurodegeneration0.87901620
78MP0001905_abnormal_dopamine_level0.87053727
79MP0002184_abnormal_innervation0.85979688
80MP0001970_abnormal_pain_threshold0.85854538
81MP0002736_abnormal_nociception_after0.84074071
82MP0001968_abnormal_touch/_nociception0.82634800
83MP0002735_abnormal_chemical_nociception0.82445950
84MP0009379_abnormal_foot_pigmentation0.77338084
85MP0004215_abnormal_myocardial_fiber0.76390992
86MP0003942_abnormal_urinary_system0.75641218
87MP0005636_abnormal_mineral_homeostasis0.74203329
88MP0005365_abnormal_bile_salt0.72778024
89MP0003183_abnormal_peptide_metabolism0.72693897
90MP0010030_abnormal_orbit_morphology0.72529531
91MP0003329_amyloid_beta_deposits0.71884061
92MP0008872_abnormal_physiological_respon0.71464536
93MP0003755_abnormal_palate_morphology0.71027966
94MP0003633_abnormal_nervous_system0.69600866
95MP0001501_abnormal_sleep_pattern0.67674257
96MP0003861_abnormal_nervous_system0.67131703
97MP0008875_abnormal_xenobiotic_pharmacok0.65018527
98MP0008057_abnormal_DNA_replication0.63436754
99MP0002752_abnormal_somatic_nervous0.62871130
100MP0000427_abnormal_hair_cycle0.61710582
101MP0001986_abnormal_taste_sensitivity0.59013375
102MP0002090_abnormal_vision0.58634917
103MP0002693_abnormal_pancreas_physiology0.56405842
104MP0002102_abnormal_ear_morphology0.56165244
105MP0005389_reproductive_system_phenotype0.54820296
106MP0005423_abnormal_somatic_nervous0.54197204
107MP0001502_abnormal_circadian_rhythm0.53536033
108MP0002234_abnormal_pharynx_morphology0.52066116
109MP0005645_abnormal_hypothalamus_physiol0.51604788
110MP0008995_early_reproductive_senescence0.49163274
111MP0003634_abnormal_glial_cell0.48371100
112MP0002909_abnormal_adrenal_gland0.48351138
113MP0002971_abnormal_brown_adipose0.47808487
114MP0000013_abnormal_adipose_tissue0.45808484
115MP0001944_abnormal_pancreas_morphology0.44015012
116MP0003631_nervous_system_phenotype0.42894693
117MP0002882_abnormal_neuron_morphology0.42499414
118MP0010329_abnormal_lipoprotein_level0.38542143
119MP0003699_abnormal_female_reproductive0.36815145
120MP0003252_abnormal_bile_duct0.36008338
121MP0004036_abnormal_muscle_relaxation0.35861054
122MP0000569_abnormal_digit_pigmentation0.34946982
123MP0002132_abnormal_respiratory_system0.34767055
124MP0003868_abnormal_feces_composition0.34536182
125MP0000604_amyloidosis0.31620877
126MP0000358_abnormal_cell_content/0.30529556
127MP0005319_abnormal_enzyme/_coenzyme0.30080146
128MP0003646_muscle_fatigue0.29807739
129MP0001119_abnormal_female_reproductive0.29735117
130MP0005646_abnormal_pituitary_gland0.29729956
131MP0001963_abnormal_hearing_physiology0.29214652
132MP0002118_abnormal_lipid_homeostasis0.29124775
133MP0005220_abnormal_exocrine_pancreas0.29103372
134MP0005085_abnormal_gallbladder_physiolo0.29023239
135MP0005334_abnormal_fat_pad0.28977725
136MP0002572_abnormal_emotion/affect_behav0.28385398
137MP0003635_abnormal_synaptic_transmissio0.28179376
138MP0005167_abnormal_blood-brain_barrier0.28074778
139MP0010386_abnormal_urinary_bladder0.27809489
140MP0004811_abnormal_neuron_physiology0.27356347
141MP0003953_abnormal_hormone_level0.26655702
142MP0004133_heterotaxia0.26361810
143MP0002078_abnormal_glucose_homeostasis0.25750468
144MP0003879_abnormal_hair_cell0.25507036
145MP0002272_abnormal_nervous_system0.24911172
146MP0005084_abnormal_gallbladder_morpholo0.24718177
147MP0004043_abnormal_pH_regulation0.23230023
148MP0000631_abnormal_neuroendocrine_gland0.23129394
149MP0006036_abnormal_mitochondrial_physio0.22778194
150MP0009115_abnormal_fat_cell0.22560358
151MP0001664_abnormal_digestion0.22435662
152MP0002152_abnormal_brain_morphology0.22333824
153MP0010307_abnormal_tumor_latency0.22228513
154MP0002067_abnormal_sensory_capabilities0.22106606
155MP0005535_abnormal_body_temperature0.21597665
156MP0001486_abnormal_startle_reflex0.21433093

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.45420008
2Abnormal respiratory epithelium morphology (HP:0012253)8.72100941
3Abnormal respiratory motile cilium morphology (HP:0005938)8.72100941
4Abnormal ciliary motility (HP:0012262)8.26880505
5Rhinitis (HP:0012384)7.74385616
6Chronic bronchitis (HP:0004469)7.21212664
7Nasal polyposis (HP:0100582)5.58128701
8Infertility (HP:0000789)5.16407417
9Bronchiectasis (HP:0002110)4.54466746
10Abnormality of the nasal mucosa (HP:0000433)4.51029802
11Nephronophthisis (HP:0000090)4.26846494
12Bronchitis (HP:0012387)4.18547231
13Recurrent sinusitis (HP:0011108)3.95417458
14Bony spicule pigmentary retinopathy (HP:0007737)3.89012034
15Medial flaring of the eyebrow (HP:0010747)3.71167100
16Molar tooth sign on MRI (HP:0002419)3.45100429
17Abnormality of midbrain morphology (HP:0002418)3.45100429
18Male infertility (HP:0003251)3.37997499
19Abnormality of the renal medulla (HP:0100957)3.29825692
20Congenital stationary night blindness (HP:0007642)3.19937807
21Recurrent otitis media (HP:0000403)3.15210451
22Tubulointerstitial nephritis (HP:0001970)2.98774557
23Decreased central vision (HP:0007663)2.83219577
24Gait imbalance (HP:0002141)2.81772847
25Congenital primary aphakia (HP:0007707)2.81218479
26Sclerocornea (HP:0000647)2.78540302
27Male pseudohermaphroditism (HP:0000037)2.74365128
28Attenuation of retinal blood vessels (HP:0007843)2.70802641
29Anencephaly (HP:0002323)2.70343029
30Abnormal spermatogenesis (HP:0008669)2.63583328
31Nephrogenic diabetes insipidus (HP:0009806)2.45699126
32Pancreatic fibrosis (HP:0100732)2.42688527
33Furrowed tongue (HP:0000221)2.35147884
34Retinitis pigmentosa (HP:0000510)2.30050230
35Abnormality of macular pigmentation (HP:0008002)2.28334179
36Chronic sinusitis (HP:0011109)2.27441337
37Chronic hepatic failure (HP:0100626)2.23438494
38Tubular atrophy (HP:0000092)2.22056012
39Tubulointerstitial abnormality (HP:0001969)2.21873847
40Abnormal rod and cone electroretinograms (HP:0008323)2.19496034
41Congenital hepatic fibrosis (HP:0002612)2.18071813
42Dyschromatopsia (HP:0007641)2.17215040
43Recurrent bronchitis (HP:0002837)2.16770277
44Preaxial hand polydactyly (HP:0001177)2.16496705
45Postaxial foot polydactyly (HP:0001830)2.15169982
46Type II diabetes mellitus (HP:0005978)2.13741090
47Oligodactyly (hands) (HP:0001180)2.13368030
48Chorioretinal atrophy (HP:0000533)2.12550291
49Genital tract atresia (HP:0001827)2.06906940
50Cone-rod dystrophy (HP:0000548)2.06377892
51Poor coordination (HP:0002370)2.05255935
52True hermaphroditism (HP:0010459)2.05244867
53Vaginal atresia (HP:0000148)2.03956410
54Azoospermia (HP:0000027)2.00173403
55Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.0011175
56Absent/shortened dynein arms (HP:0200106)11.5895068
57Dynein arm defect of respiratory motile cilia (HP:0012255)11.5895068
58Constricted visual fields (HP:0001133)1.96976626
59Narrow forehead (HP:0000341)1.92821967
60Type II lissencephaly (HP:0007260)1.92624590
61Aplasia/Hypoplasia of the tongue (HP:0010295)1.92459330
62Anophthalmia (HP:0000528)1.91855897
63Absent rod-and cone-mediated responses on ERG (HP:0007688)1.91694893
64Cystic liver disease (HP:0006706)1.90418471
65Aplasia/Hypoplasia of the lens (HP:0008063)1.88985411
66Postaxial hand polydactyly (HP:0001162)1.88412545
67Optic nerve hypoplasia (HP:0000609)1.84116463
68Chronic otitis media (HP:0000389)1.83000731
69Pendular nystagmus (HP:0012043)1.82996657
70Abolished electroretinogram (ERG) (HP:0000550)1.81994501
71Mitochondrial inheritance (HP:0001427)1.80399402
72Central scotoma (HP:0000603)1.79417130
73Aplasia/hypoplasia of the uterus (HP:0008684)1.78052095
74Lipid accumulation in hepatocytes (HP:0006561)1.78035744
75Increased hepatocellular lipid droplets (HP:0006565)1.77876125
76Aplasia/Hypoplasia of the fibula (HP:0006492)1.77696866
77Macular degeneration (HP:0000608)1.76678549
78Abnormality of the renal cortex (HP:0011035)1.76144826
79Abnormality of permanent molar morphology (HP:0011071)1.75231133
80Abnormality of the dental root (HP:0006486)1.75231133
81Taurodontia (HP:0000679)1.75231133
82Stage 5 chronic kidney disease (HP:0003774)1.74844861
83Split foot (HP:0001839)1.72014739
84Oculomotor apraxia (HP:0000657)1.71374845
85Pancreatic cysts (HP:0001737)1.71332335
86Polyuria (HP:0000103)1.69254501
87Fibular hypoplasia (HP:0003038)1.69026378
88Fibular aplasia (HP:0002990)1.68155152
89Congenital sensorineural hearing impairment (HP:0008527)1.67182760
90Photophobia (HP:0000613)1.66966154
91Abnormal drinking behavior (HP:0030082)1.65967961
92Polydipsia (HP:0001959)1.65967961
93Tongue fasciculations (HP:0001308)1.65835333
94Abnormality of molar (HP:0011077)1.64504147
95Abnormality of molar morphology (HP:0011070)1.64504147
96Abnormality of the dental pulp (HP:0006479)1.64370801
97Median cleft lip (HP:0000161)1.64277146
98Acute necrotizing encephalopathy (HP:0006965)1.64160834
99Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.63077959
100Scotoma (HP:0000575)1.59857585
101Aganglionic megacolon (HP:0002251)1.58596448
102Prominent nasal bridge (HP:0000426)1.58241620
103Supernumerary spleens (HP:0009799)1.57065423
104Abnormality of the lower motor neuron (HP:0002366)1.53890759
105Specific learning disability (HP:0001328)1.53765860
106Pigmentary retinal degeneration (HP:0001146)1.52990208
107Tubulointerstitial fibrosis (HP:0005576)1.52636687
108Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.52515050
109Abnormality of dentin (HP:0010299)1.51933683
110Humeroradial synostosis (HP:0003041)1.51491346
111Synostosis involving the elbow (HP:0003938)1.51491346
112Abnormal gallbladder physiology (HP:0012438)1.51134525
113Cholecystitis (HP:0001082)1.51134525
114Abnormality of saccadic eye movements (HP:0000570)1.50891629
115Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.49813755
116Aplasia/Hypoplasia of the spleen (HP:0010451)1.49131625
117Choroideremia (HP:0001139)1.48876242
118Hemiparesis (HP:0001269)1.48743917
119Microglossia (HP:0000171)1.48697800
120Asplenia (HP:0001746)1.48687181
121Hypoplastic pelvis (HP:0008839)1.48593349
122Abnormal biliary tract physiology (HP:0012439)1.48291573
123Bile duct proliferation (HP:0001408)1.48291573
124Renal dysplasia (HP:0000110)1.47436436
125Oligodactyly (HP:0012165)1.47301906
126Abnormality of renal excretion (HP:0011036)1.47242671
127Increased CSF lactate (HP:0002490)1.46684300
128Facial cleft (HP:0002006)1.46559092
129Esophageal atresia (HP:0002032)1.44104266
130Muscle fibrillation (HP:0010546)1.43362692
131Highly arched eyebrow (HP:0002553)1.43115999
132Renal Fanconi syndrome (HP:0001994)1.42956814
133Cerebellar dysplasia (HP:0007033)1.42070444
134Occipital encephalocele (HP:0002085)1.41389690
135Retinal atrophy (HP:0001105)1.40628207
136Nephropathy (HP:0000112)1.40534454
137Large for gestational age (HP:0001520)1.40528546
138Gastrointestinal atresia (HP:0002589)1.40198913
139Abnormality of ocular smooth pursuit (HP:0000617)1.40140229
140Progressive macrocephaly (HP:0004481)1.40114477
141Abnormal urine output (HP:0012590)1.39547857
142Acute encephalopathy (HP:0006846)1.38036037
143Abnormality of the pons (HP:0007361)1.36298614
144Scrotal hypoplasia (HP:0000046)1.35159927

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK39.56656608
2PDK49.56656608
3PDK26.21167505
4TESK13.14452871
5PRKD32.64235043
6TNIK2.28434896
7TSSK62.18380588
8WNK42.09681940
9PTK2B2.07111478
10ICK1.98197459
11TLK11.93494318
12STK391.86685415
13MAP4K21.85884138
14MST41.83556626
15STK161.80092885
16TRIM281.65623193
17VRK11.54867351
18CASK1.53117486
19MAPK131.49045171
20LMTK21.48976516
21CDK31.38665344
22ADRBK21.35854871
23STK381.35297648
24PNCK1.31051668
25NUAK11.31044681
26FRK1.25706280
27MAPK151.20439342
28IRAK11.13002257
29NEK21.11852896
30MARK11.11500972
31IRAK21.11219732
32NME11.06191556
33GRK11.00849735
34MAP3K121.00497675
35TGFBR10.99991824
36ZAK0.99403896
37STK38L0.98679649
38PDK10.95876236
39MAP2K40.94854236
40DYRK1B0.91814018
41EPHA40.91206158
42DYRK20.91052760
43CSNK1G20.89263595
44MAPKAPK30.89037773
45BCR0.87720090
46PHKG10.87501904
47PHKG20.87501904
48STK240.84192619
49MKNK20.81225774
50OXSR10.73377017
51PBK0.71614831
52PINK10.70720814
53INSRR0.70127202
54RIPK40.69031714
55MAP2K60.68675065
56TXK0.68062267
57ADRBK10.67664599
58LATS10.65870204
59NTRK30.64629450
60PRKCE0.62230695
61RPS6KA50.59660081
62WNK10.58231795
63BCKDK0.58026217
64PASK0.56644130
65MAP2K70.55848660
66TYRO30.54807242
67STK110.51759976
68DYRK30.51581594
69CCNB10.51288224
70CDK80.50600130
71PLK20.50462252
72OBSCN0.50142135
73ERBB20.47864242
74BMPR1B0.46154189
75MAP3K40.45399359
76ROCK10.45010525
77PRKCG0.44757177
78PIK3CA0.43551400
79CHEK20.43530838
80CSNK1G10.42017209
81PDPK10.41363069
82NTRK20.40077429
83EPHB20.39720938
84STK30.38935247
85TTK0.38504033
86TIE10.36747624
87PAK30.35102399
88CSNK1G30.33123808
89MYLK0.32649885
90CAMKK20.32071687
91CHUK0.30166001
92PRKAA10.30029459
93BRSK20.29888194
94PRKG20.29367787
95MKNK10.28594877
96CAMK1G0.28540214
97NEK60.28205988
98MAPK70.28137230
99CAMK10.28033112
100EPHA20.27303905
101SGK4940.27285852
102SGK2230.27285852
103MET0.26889012
104AURKA0.26823133
105TAOK30.26600002
106MUSK0.25611160
107PRKCZ0.25408332
108FGFR20.25367508
109PIK3CG0.25098045
110CSNK1A10.25059375
111GSK3A0.25010154
112CHEK10.24736000
113EPHA30.23246287
114PRKACG0.22425792
115MAPKAPK50.22389616
116WNK30.22200632
117CAMKK10.21843414
118PRKG10.18003869
119PLK40.17895281
120CAMK2A0.17072161
121ATM0.15286840
122ERBB30.14474068
123PRKCQ0.14267353
124ZAP700.12949347
125ACVR1B0.12898747
126MARK20.12764720
127CSK0.11971138
128PRKACB0.11012257
129MAP3K60.10004069
130PAK10.09791948
131RPS6KB10.09639387
132MAP3K20.09372451
133YES10.09330603
134DYRK1A0.09305961
135PRKACA0.09267229
136PRKCA0.09051048
137WEE10.08086805
138PRKAA20.07718668
139PRKCB0.07652584
140PDGFRB0.06836940
141BMPR20.06725545
142BRSK10.06470041
143PKN10.05182428
144CAMK2D0.04544230
145PLK10.04416913
146RPS6KA30.04209335
147PAK60.03677456
148MAP3K50.03651800
149ATR0.03582419
150CDK150.03253459
151CDK50.03103678
152PRKCD0.02659129
153RIPK10.02593454
154GSK3B0.02383030
155EPHB10.02168272
156CDK180.01122429
157GRK50.00661653
158PRKCH0.00027649
159CDK140.00015547

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047444.96750009
2Glycolysis / Gluconeogenesis_Homo sapiens_hsa000103.98908070
3Oxidative phosphorylation_Homo sapiens_hsa001903.55000620
4Pyruvate metabolism_Homo sapiens_hsa006203.46617501
5Vitamin B6 metabolism_Homo sapiens_hsa007503.43126324
6Parkinsons disease_Homo sapiens_hsa050123.27079023
7Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005122.83935691
8Pentose phosphate pathway_Homo sapiens_hsa000302.66711738
9Glucagon signaling pathway_Homo sapiens_hsa049222.63547595
10Protein export_Homo sapiens_hsa030602.59474779
11Propanoate metabolism_Homo sapiens_hsa006402.53525527
12Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.47937835
13Fatty acid biosynthesis_Homo sapiens_hsa000612.41141248
14Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.14643182
15Alzheimers disease_Homo sapiens_hsa050102.13223065
16Nitrogen metabolism_Homo sapiens_hsa009102.03513592
17Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.00798757
18Glycosaminoglycan degradation_Homo sapiens_hsa005311.98762162
19Primary bile acid biosynthesis_Homo sapiens_hsa001201.92558411
20alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.87003776
21Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.86628623
22Butanoate metabolism_Homo sapiens_hsa006501.85432538
23Ribosome_Homo sapiens_hsa030101.85388549
24Hedgehog signaling pathway_Homo sapiens_hsa043401.85070399
25Maturity onset diabetes of the young_Homo sapiens_hsa049501.82215156
26Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.81799073
27Linoleic acid metabolism_Homo sapiens_hsa005911.80807897
28Carbohydrate digestion and absorption_Homo sapiens_hsa049731.76382362
29Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.73554591
30Olfactory transduction_Homo sapiens_hsa047401.73173647
31Glycerolipid metabolism_Homo sapiens_hsa005611.70425548
32Basal transcription factors_Homo sapiens_hsa030221.68242656
33Carbon metabolism_Homo sapiens_hsa012001.53637893
34RNA polymerase_Homo sapiens_hsa030201.53405143
35Fructose and mannose metabolism_Homo sapiens_hsa000511.51394570
36Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.46572855
37Basal cell carcinoma_Homo sapiens_hsa052171.46219241
38Selenocompound metabolism_Homo sapiens_hsa004501.42223987
39Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.41615049
40Insulin secretion_Homo sapiens_hsa049111.40568868
41Glycerophospholipid metabolism_Homo sapiens_hsa005641.37970800
42Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.36246506
43Mineral absorption_Homo sapiens_hsa049781.35945767
44Amphetamine addiction_Homo sapiens_hsa050311.35906025
45Peroxisome_Homo sapiens_hsa041461.35125452
46beta-Alanine metabolism_Homo sapiens_hsa004101.34826325
47Tyrosine metabolism_Homo sapiens_hsa003501.29927897
48Steroid hormone biosynthesis_Homo sapiens_hsa001401.29474927
49Oocyte meiosis_Homo sapiens_hsa041141.28607445
50PPAR signaling pathway_Homo sapiens_hsa033201.28049283
51Synaptic vesicle cycle_Homo sapiens_hsa047211.25994270
52Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.25694198
53Steroid biosynthesis_Homo sapiens_hsa001001.25449224
54Collecting duct acid secretion_Homo sapiens_hsa049661.25300943
55Sulfur metabolism_Homo sapiens_hsa009201.23750493
56Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.21398597
57Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.20431353
58Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.18191001
59Biosynthesis of amino acids_Homo sapiens_hsa012301.13875400
60Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.13830924
61Dorso-ventral axis formation_Homo sapiens_hsa043201.10329769
62Renin secretion_Homo sapiens_hsa049241.10252203
63Fanconi anemia pathway_Homo sapiens_hsa034601.10063271
64ABC transporters_Homo sapiens_hsa020101.08456967
65Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.03729603
66Tryptophan metabolism_Homo sapiens_hsa003801.01375130
67Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.00891865
68Ether lipid metabolism_Homo sapiens_hsa005650.99441359
69Huntingtons disease_Homo sapiens_hsa050160.95725906
70Caffeine metabolism_Homo sapiens_hsa002320.94540666
71Fatty acid degradation_Homo sapiens_hsa000710.92590596
72Fat digestion and absorption_Homo sapiens_hsa049750.92034502
73Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.91888383
74Circadian entrainment_Homo sapiens_hsa047130.91273434
75Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.89837326
76Inositol phosphate metabolism_Homo sapiens_hsa005620.88986701
77Cysteine and methionine metabolism_Homo sapiens_hsa002700.88512050
78Retinol metabolism_Homo sapiens_hsa008300.88474258
79Phosphatidylinositol signaling system_Homo sapiens_hsa040700.86463162
80Chemical carcinogenesis_Homo sapiens_hsa052040.86416421
81Taste transduction_Homo sapiens_hsa047420.85502423
82Cardiac muscle contraction_Homo sapiens_hsa042600.83437798
83Bile secretion_Homo sapiens_hsa049760.82213629
84Purine metabolism_Homo sapiens_hsa002300.79078403
85Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.76249112
86Fatty acid metabolism_Homo sapiens_hsa012120.73617905
87Proteasome_Homo sapiens_hsa030500.71450275
88Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.70996040
89Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.70363471
90Morphine addiction_Homo sapiens_hsa050320.68083442
91Thyroid hormone synthesis_Homo sapiens_hsa049180.66344689
92Axon guidance_Homo sapiens_hsa043600.66171652
93Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.65466387
94Calcium signaling pathway_Homo sapiens_hsa040200.63439991
95Glutathione metabolism_Homo sapiens_hsa004800.63059876
96cGMP-PKG signaling pathway_Homo sapiens_hsa040220.62651878
97Hippo signaling pathway_Homo sapiens_hsa043900.60885814
98Dopaminergic synapse_Homo sapiens_hsa047280.60443657
99Long-term potentiation_Homo sapiens_hsa047200.60109378
100Serotonergic synapse_Homo sapiens_hsa047260.59192137
101Glutamatergic synapse_Homo sapiens_hsa047240.59054267
102Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.58916262
103Renin-angiotensin system_Homo sapiens_hsa046140.58790568
104Estrogen signaling pathway_Homo sapiens_hsa049150.57232196
105Pancreatic secretion_Homo sapiens_hsa049720.56667626
106Nucleotide excision repair_Homo sapiens_hsa034200.56317101
107Central carbon metabolism in cancer_Homo sapiens_hsa052300.55552735
108Histidine metabolism_Homo sapiens_hsa003400.52863627
109Folate biosynthesis_Homo sapiens_hsa007900.52295010
110cAMP signaling pathway_Homo sapiens_hsa040240.52226021
111Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.51923123
112RNA degradation_Homo sapiens_hsa030180.48600296
113Gap junction_Homo sapiens_hsa045400.46438313
114Salivary secretion_Homo sapiens_hsa049700.46360199
115Regulation of autophagy_Homo sapiens_hsa041400.45644586
116Cocaine addiction_Homo sapiens_hsa050300.45382702
117Vibrio cholerae infection_Homo sapiens_hsa051100.44654240
118Systemic lupus erythematosus_Homo sapiens_hsa053220.44557493
119Metabolic pathways_Homo sapiens_hsa011000.41546536
120TGF-beta signaling pathway_Homo sapiens_hsa043500.41497352
121GABAergic synapse_Homo sapiens_hsa047270.41399458
122Wnt signaling pathway_Homo sapiens_hsa043100.41138833
123N-Glycan biosynthesis_Homo sapiens_hsa005100.40969617
124Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.40490287
125Vitamin digestion and absorption_Homo sapiens_hsa049770.38761451
126Arachidonic acid metabolism_Homo sapiens_hsa005900.38283686
127Phenylalanine metabolism_Homo sapiens_hsa003600.38252398
128Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.37670596
129Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.36794876
130Tight junction_Homo sapiens_hsa045300.36660445
131Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.36601670
132Gastric acid secretion_Homo sapiens_hsa049710.35060226
133Complement and coagulation cascades_Homo sapiens_hsa046100.34261577
134Homologous recombination_Homo sapiens_hsa034400.33758311
135Nicotine addiction_Homo sapiens_hsa050330.33699173
136Melanogenesis_Homo sapiens_hsa049160.33453110
137Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.33302595
138mRNA surveillance pathway_Homo sapiens_hsa030150.31526605
139Fatty acid elongation_Homo sapiens_hsa000620.30865463
140Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.30384416
141Aldosterone synthesis and secretion_Homo sapiens_hsa049250.28576329
142Pentose and glucuronate interconversions_Homo sapiens_hsa000400.28343420
143AMPK signaling pathway_Homo sapiens_hsa041520.27351810
144Circadian rhythm_Homo sapiens_hsa047100.26981189
145Alcoholism_Homo sapiens_hsa050340.26535775
146Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.25278391
147Type II diabetes mellitus_Homo sapiens_hsa049300.25164787
148Adipocytokine signaling pathway_Homo sapiens_hsa049200.25084664
149Antigen processing and presentation_Homo sapiens_hsa046120.24482167
150Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.21043277

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