PPP1R7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein subunit that regulates the activity of the serine/threonine phosphatase, protein phosphatase-1. The encoded protein is required for completion of the mitotic cycle and for targeting protein phosphatase-1 to mitotic kinetochores. Alternate splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.37131985
2ATP synthesis coupled proton transport (GO:0015986)5.66599231
3energy coupled proton transport, down electrochemical gradient (GO:0015985)5.66599231
4regulation of short-term neuronal synaptic plasticity (GO:0048172)5.42484000
5positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.40056429
6mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.33467145
7chaperone-mediated protein transport (GO:0072321)5.22971819
8establishment of protein localization to mitochondrial membrane (GO:0090151)5.14198152
9respiratory electron transport chain (GO:0022904)5.13140615
10vocalization behavior (GO:0071625)5.10791159
11synaptic vesicle exocytosis (GO:0016079)5.04854284
12electron transport chain (GO:0022900)5.02348665
13regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.94441853
14synaptic vesicle maturation (GO:0016188)4.87332893
15protein localization to synapse (GO:0035418)4.84507443
16synaptic vesicle docking involved in exocytosis (GO:0016081)4.71963474
17ribosomal small subunit biogenesis (GO:0042274)4.68359597
18positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.67314254
19locomotory exploration behavior (GO:0035641)4.66512731
20regulation of glutamate receptor signaling pathway (GO:1900449)4.53636629
21regulation of synaptic vesicle exocytosis (GO:2000300)4.46197817
22glutamate secretion (GO:0014047)4.45998757
23proteasome assembly (GO:0043248)4.43291719
24axonemal dynein complex assembly (GO:0070286)4.31454587
25neuron-neuron synaptic transmission (GO:0007270)4.28779403
26neuron cell-cell adhesion (GO:0007158)4.26702962
27regulation of long-term neuronal synaptic plasticity (GO:0048169)4.26173523
28ionotropic glutamate receptor signaling pathway (GO:0035235)4.23801919
29protein neddylation (GO:0045116)4.21100793
30neurotransmitter-gated ion channel clustering (GO:0072578)4.20717599
31regulation of cellular amino acid metabolic process (GO:0006521)4.19108468
32synaptic transmission, dopaminergic (GO:0001963)4.10112902
33viral transcription (GO:0019083)4.08464974
34regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.08271199
35deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.07014910
36protein complex biogenesis (GO:0070271)4.05077440
37synaptic transmission, glutamatergic (GO:0035249)4.04654805
38negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.04627056
39neuronal action potential propagation (GO:0019227)4.03972460
40protein targeting to mitochondrion (GO:0006626)4.02175032
41purine nucleotide salvage (GO:0032261)4.00055814
42regulation of synaptic vesicle transport (GO:1902803)3.98935262
43neurotransmitter secretion (GO:0007269)3.96967534
44maturation of SSU-rRNA (GO:0030490)3.96416661
45protein targeting to ER (GO:0045047)3.91909911
46glutamate receptor signaling pathway (GO:0007215)3.90775017
47regulation of neuronal synaptic plasticity (GO:0048168)3.90382159
48SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.90137895
49regulation of synapse structural plasticity (GO:0051823)3.88455558
50tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.87488678
51RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.87488678
52translational termination (GO:0006415)3.87480392
53cotranslational protein targeting to membrane (GO:0006613)3.85431646
54protein maturation by protein folding (GO:0022417)3.84236996
55mitochondrial respiratory chain complex assembly (GO:0033108)3.81359222
56exploration behavior (GO:0035640)3.79953314
57protein localization to endoplasmic reticulum (GO:0070972)3.78874148
58positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.78790769
59negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.76973001
60negative regulation of ligase activity (GO:0051352)3.76973001
61antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.75970781
62positive regulation of membrane potential (GO:0045838)3.75868074
63establishment of protein localization to endoplasmic reticulum (GO:0072599)3.75445223
64regulation of excitatory postsynaptic membrane potential (GO:0060079)3.74059039
65DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.73630712
66positive regulation of neurotransmitter transport (GO:0051590)3.72927806
67behavioral response to cocaine (GO:0048148)3.72575443
68membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.71798762
69establishment of protein localization to mitochondrion (GO:0072655)3.70820542
70regulation of autophagic vacuole assembly (GO:2000785)3.67664371
71hydrogen ion transmembrane transport (GO:1902600)3.67219107
72long-term memory (GO:0007616)3.67065255
73regulation of mitochondrial translation (GO:0070129)3.66322192
74positive regulation of synapse maturation (GO:0090129)3.65098450
75translational elongation (GO:0006414)3.64671407
76regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.64480022
77negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.63684711
78regulation of oxidative phosphorylation (GO:0002082)3.63157312
79response to histamine (GO:0034776)3.62386905
80protein localization to mitochondrion (GO:0070585)3.61384859
81striatum development (GO:0021756)3.60974595
82positive regulation of neurotransmitter secretion (GO:0001956)3.59877253
83intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.59115914
84signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.59115914
85behavioral fear response (GO:0001662)3.58636316
86behavioral defense response (GO:0002209)3.58636316
87long-term synaptic potentiation (GO:0060291)3.56469145
88antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.54655405
89regulation of dopamine uptake involved in synaptic transmission (GO:0051584)3.53735542
90regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)3.53735542
91regulation of postsynaptic membrane potential (GO:0060078)3.53696524
92gamma-aminobutyric acid signaling pathway (GO:0007214)3.52700535
93mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.52687612
94mitochondrial respiratory chain complex I assembly (GO:0032981)3.52687612
95NADH dehydrogenase complex assembly (GO:0010257)3.52687612
96ribosomal large subunit biogenesis (GO:0042273)3.51872903
97regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.51845960
98signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.50863801
99signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.50863801
100signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.50863801
101regulation of dendritic spine morphogenesis (GO:0061001)3.50723069
102ribosomal small subunit assembly (GO:0000028)3.49052546
103prepulse inhibition (GO:0060134)3.47534146
104negative regulation of synaptic transmission, GABAergic (GO:0032229)3.46938388
105ATP hydrolysis coupled proton transport (GO:0015991)3.46378264
106energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.46378264
107purine nucleoside triphosphate biosynthetic process (GO:0009145)3.44563721
108ATP biosynthetic process (GO:0006754)3.43317676
109regulation of synaptic plasticity (GO:0048167)3.42062201
1102-deoxyribonucleotide biosynthetic process (GO:0009265)3.41877905
111deoxyribose phosphate biosynthetic process (GO:0046385)3.41877905
112signal transduction involved in DNA damage checkpoint (GO:0072422)3.41391239
113signal transduction involved in DNA integrity checkpoint (GO:0072401)3.41391239
114purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.40111355
115translation (GO:0006412)3.39060884
116regulation of synaptic transmission, glutamatergic (GO:0051966)3.39030233
117GDP-mannose metabolic process (GO:0019673)3.38770206
118synaptic vesicle endocytosis (GO:0048488)3.37774907
119negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.35848112
120nucleobase-containing small molecule interconversion (GO:0015949)3.32904039
121pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.32493346
122fear response (GO:0042596)3.31991335
123signal transduction involved in cell cycle checkpoint (GO:0072395)3.31359522
124anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.30279684
125positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.30176813
126GTP biosynthetic process (GO:0006183)3.29958003
127regulation of cellular amine metabolic process (GO:0033238)3.28690134
128transmission of nerve impulse (GO:0019226)3.27980871
129presynaptic membrane assembly (GO:0097105)3.26702085
130positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.26663496
131positive regulation of dendritic spine morphogenesis (GO:0061003)3.26112336
132viral life cycle (GO:0019058)3.25474598
133negative regulation of dendrite morphogenesis (GO:0050774)3.24957820
134regulation of neurotransmitter secretion (GO:0046928)3.24344038
135neurotransmitter transport (GO:0006836)3.23296829
136cullin deneddylation (GO:0010388)3.22496098
137G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.22134625
138regulation of voltage-gated calcium channel activity (GO:1901385)3.21294349
139auditory behavior (GO:0031223)3.21077440
140positive regulation of ligase activity (GO:0051351)3.20412734
141proton transport (GO:0015992)3.18129662
142rRNA modification (GO:0000154)3.17598357
143cellular component biogenesis (GO:0044085)3.15314816
144regulation of neurotransmitter transport (GO:0051588)3.14474956
145hydrogen transport (GO:0006818)3.13694203
146postsynaptic membrane organization (GO:0001941)3.13410471
147protein deneddylation (GO:0000338)3.12940808
148membrane hyperpolarization (GO:0060081)3.12806570
149oxidative phosphorylation (GO:0006119)3.12360678
150gamma-aminobutyric acid transport (GO:0015812)3.12074643
151cellular protein complex disassembly (GO:0043624)3.11669576
152positive regulation of synaptic transmission, GABAergic (GO:0032230)3.10425618
153layer formation in cerebral cortex (GO:0021819)3.10304678
154response to amphetamine (GO:0001975)3.10205026
155pteridine-containing compound biosynthetic process (GO:0042559)3.09517208
156regulation of glutamate secretion (GO:0014048)3.06426437
157translational initiation (GO:0006413)3.06315266
158regulation of vacuole organization (GO:0044088)3.06297598
159learning (GO:0007612)3.05726305
160dendritic spine morphogenesis (GO:0060997)3.03567275
161neuromuscular process controlling balance (GO:0050885)3.03204588
162nucleoside diphosphate phosphorylation (GO:0006165)3.02116073
163G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.02080948
164presynaptic membrane organization (GO:0097090)3.02036100
165membrane depolarization (GO:0051899)3.01939962
166cytochrome complex assembly (GO:0017004)3.01524423
167adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.01463825
168regulation of neurotransmitter uptake (GO:0051580)3.01395881
169ribonucleoprotein complex biogenesis (GO:0022613)3.01141895
170aerobic respiration (GO:0009060)3.01000529
171aldehyde catabolic process (GO:0046185)3.00603076
172mitochondrial transport (GO:0006839)3.00578799
173regulation of neurotransmitter levels (GO:0001505)3.00295768
174termination of RNA polymerase III transcription (GO:0006386)3.00068322
175transcription elongation from RNA polymerase III promoter (GO:0006385)3.00068322
176positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.98177673
177deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.98029462
178nucleoside triphosphate biosynthetic process (GO:0009142)2.96809111
179regulation of female receptivity (GO:0045924)2.96640283
180ribonucleoside triphosphate biosynthetic process (GO:0009201)2.95806663
181respiratory chain complex IV assembly (GO:0008535)2.95742882
182negative regulation of dendrite development (GO:2000171)2.94909362
183deoxyribonucleotide biosynthetic process (GO:0009263)2.94578124
184startle response (GO:0001964)2.93465219
185guanosine-containing compound biosynthetic process (GO:1901070)2.93241260
186positive regulation of synaptic transmission (GO:0050806)2.90791908
187mechanosensory behavior (GO:0007638)2.90488131
188regulation of vesicle fusion (GO:0031338)2.89876503
189dopamine receptor signaling pathway (GO:0007212)2.89750042
190response to auditory stimulus (GO:0010996)2.88189664
191membrane depolarization during action potential (GO:0086010)2.88146173
192cerebellar Purkinje cell differentiation (GO:0021702)2.87563962
193synaptic transmission (GO:0007268)2.85456955
194adult walking behavior (GO:0007628)2.83836155
195neuron recognition (GO:0008038)2.82001838
196regulation of synapse maturation (GO:0090128)2.81834732
197regulation of dendritic spine development (GO:0060998)2.81827588
198regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.81127914
199regulation of synaptic transmission, GABAergic (GO:0032228)2.80922407
200female mating behavior (GO:0060180)2.80251888

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.75131813
2GBX2_23144817_ChIP-Seq_PC3_Human4.25109371
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.05631525
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.04415298
5* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.81975556
6GABP_17652178_ChIP-ChIP_JURKAT_Human3.76569293
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.76046496
8* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.71334991
9ELF1_17652178_ChIP-ChIP_JURKAT_Human3.68607973
10NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.23407792
11EST1_17652178_ChIP-ChIP_JURKAT_Human2.99708421
12RARB_27405468_Chip-Seq_BRAIN_Mouse2.96674559
13HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.95905496
14* ETS1_20019798_ChIP-Seq_JURKAT_Human2.91010424
15REST_21632747_ChIP-Seq_MESCs_Mouse2.85008692
16CREB1_15753290_ChIP-ChIP_HEK293T_Human2.78634600
17SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.75896360
18MYC_18555785_ChIP-Seq_MESCs_Mouse2.74087928
19* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.69702098
20JARID2_20064375_ChIP-Seq_MESCs_Mouse2.64586832
21* PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.54144037
22SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.50980830
23ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.49488379
24* SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.48465343
25CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.38436537
26REST_18959480_ChIP-ChIP_MESCs_Mouse2.34094615
27TAF15_26573619_Chip-Seq_HEK293_Human2.28973459
28NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.22976459
29EZH2_27304074_Chip-Seq_ESCs_Mouse2.15283373
30* SRF_21415370_ChIP-Seq_HL-1_Mouse2.13640667
31SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.10788830
32JARID2_20075857_ChIP-Seq_MESCs_Mouse2.09723284
33CEBPB_24764292_ChIP-Seq_MC3T3_Mouse2.08538948
34RNF2_18974828_ChIP-Seq_MESCs_Mouse2.06255429
35EZH2_18974828_ChIP-Seq_MESCs_Mouse2.06255429
36CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.06223513
37XRN2_22483619_ChIP-Seq_HELA_Human2.05606962
38CTBP2_25329375_ChIP-Seq_LNCAP_Human2.04669575
39GABP_19822575_ChIP-Seq_HepG2_Human2.04155230
40* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.02378409
41SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.02045553
42GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.98273086
43MYC_19079543_ChIP-ChIP_MESCs_Mouse1.97987296
44DCP1A_22483619_ChIP-Seq_HELA_Human1.93946375
45YY1_21170310_ChIP-Seq_MESCs_Mouse1.93622790
46CTBP1_25329375_ChIP-Seq_LNCAP_Human1.92394594
47* VDR_23849224_ChIP-Seq_CD4+_Human1.92367542
48DROSHA_22980978_ChIP-Seq_HELA_Human1.91471507
49FOXP3_21729870_ChIP-Seq_TREG_Human1.89624886
50FUS_26573619_Chip-Seq_HEK293_Human1.87866532
51SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.86894442
52SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.85538270
53MTF2_20144788_ChIP-Seq_MESCs_Mouse1.85326969
54FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.85180239
55SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.84881203
56IKZF1_21737484_ChIP-ChIP_HCT116_Human1.84851769
57AR_21572438_ChIP-Seq_LNCaP_Human1.83427677
58* SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.80814338
59* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.80041613
60HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.79949242
61ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.79787439
62MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.78929017
63SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.76129172
64GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.76116032
65SMAD4_21799915_ChIP-Seq_A2780_Human1.75872407
66CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.73190099
67ZFP57_27257070_Chip-Seq_ESCs_Mouse1.71911380
68RNF2_27304074_Chip-Seq_ESCs_Mouse1.71816614
69EED_16625203_ChIP-ChIP_MESCs_Mouse1.68544328
70BP1_19119308_ChIP-ChIP_Hs578T_Human1.64964084
71P300_19829295_ChIP-Seq_ESCs_Human1.64323753
72EZH2_27294783_Chip-Seq_ESCs_Mouse1.61333308
73SUZ12_27294783_Chip-Seq_ESCs_Mouse1.58221029
74PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.57020563
75SRY_22984422_ChIP-ChIP_TESTIS_Rat1.56514842
76SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.55655844
77MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.48698801
78THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.47854946
79SMAD3_21741376_ChIP-Seq_EPCs_Human1.47350608
80TTF2_22483619_ChIP-Seq_HELA_Human1.44831919
81* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.43538514
82CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.42806828
83BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.41874659
84POU3F2_20337985_ChIP-ChIP_501MEL_Human1.40799046
85* ELF1_20517297_ChIP-Seq_JURKAT_Human1.40673225
86NELFA_20434984_ChIP-Seq_ESCs_Mouse1.39770599
87SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.39296302
88ZNF274_21170338_ChIP-Seq_K562_Hela1.37475496
89RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.36866706
90BMI1_23680149_ChIP-Seq_NPCS_Mouse1.36567734
91* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.36391123
92EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.34024358
93RBPJ_22232070_ChIP-Seq_NCS_Mouse1.33617736
94* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.33276221
95STAT3_23295773_ChIP-Seq_U87_Human1.32113470
96SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.29612323
97PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.28053299
98TCF4_23295773_ChIP-Seq_U87_Human1.27596954
99TET1_21451524_ChIP-Seq_MESCs_Mouse1.26856557
100SOX2_21211035_ChIP-Seq_LN229_Gbm1.23922306
101MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.23473784
102RNF2_27304074_Chip-Seq_NSC_Mouse1.22918075
103* P53_22127205_ChIP-Seq_FIBROBLAST_Human1.22816668
104TOP2B_26459242_ChIP-Seq_MCF-7_Human1.22273808
105FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.22214723
106TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.19805342
107ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.19772535
108ZFX_18555785_ChIP-Seq_MESCs_Mouse1.19377091
109JUN_21703547_ChIP-Seq_K562_Human1.18880120
110OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.18358344
111* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.18324503
112PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.18278397
113* POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.18120058
114ZNF263_19887448_ChIP-Seq_K562_Human1.17821480
115* SOX9_26525672_Chip-Seq_HEART_Mouse1.17681580
116TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.17525401
117TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.16615937
118TBX5_21415370_ChIP-Seq_HL-1_Mouse1.16554721
119CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.15757397
120* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.14890341
121TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.14032780
122DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.13873312
123SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.13769128
124CTCF_18555785_ChIP-Seq_MESCs_Mouse1.12977770
125AR_25329375_ChIP-Seq_VCAP_Human1.12616777
126NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.12506064
127CBX2_27304074_Chip-Seq_ESCs_Mouse1.11515258
128RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.11376248
129BCL6_27268052_Chip-Seq_Bcells_Human1.11360218
130EWS_26573619_Chip-Seq_HEK293_Human1.10076815
131ER_23166858_ChIP-Seq_MCF-7_Human1.09350572
132PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.07410372
133PRDM14_20953172_ChIP-Seq_ESCs_Human1.06911855
134AR_19668381_ChIP-Seq_PC3_Human1.06544225
135TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.06526995
136SMAD_19615063_ChIP-ChIP_OVARY_Human1.06436216
137CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.06288031
138STAT1_20625510_ChIP-Seq_HELA_Human1.06253886
139CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.05714596
140YY1_22570637_ChIP-Seq_MALME-3M_Human1.03701327
141MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.03485540
142TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.03270882
143ELK1_19687146_ChIP-ChIP_HELA_Human1.03206637
144* PU.1_20513432_ChIP-Seq_Bcells_Mouse1.03150978
145CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02974066
146NANOG_18555785_Chip-Seq_ESCs_Mouse1.02509338
147FLI1_27457419_Chip-Seq_LIVER_Mouse1.02455857
148PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.02206937
149NR3C1_23031785_ChIP-Seq_PC12_Mouse1.01816976
150UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.01770322
151TFEB_21752829_ChIP-Seq_HELA_Human1.01616606
152CTCF_26484167_Chip-Seq_Bcells_Mouse1.01576957
153YAP1_20516196_ChIP-Seq_MESCs_Mouse1.01545933
154IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.01200610
155E2F1_18555785_Chip-Seq_ESCs_Mouse1.01036469
156* RUNX2_22187159_ChIP-Seq_PCA_Human1.00820752
157HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.00792291
158HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.98753180
159EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.98548424
160KDM5A_27292631_Chip-Seq_BREAST_Human0.98276085
161MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.98064164
162CTCF_20526341_ChIP-Seq_ESCs_Human0.98009777
163PCGF2_27294783_Chip-Seq_ESCs_Mouse0.97643784
164CIITA_25753668_ChIP-Seq_RAJI_Human0.97567525
165* P68_20966046_ChIP-Seq_HELA_Human0.97370394
166LXR_22292898_ChIP-Seq_THP-1_Human0.97033491
167FOXP1_21924763_ChIP-Seq_HESCs_Human0.96938871
168* MYCN_18555785_ChIP-Seq_MESCs_Mouse0.96348933
169ELK1_22589737_ChIP-Seq_MCF10A_Human0.96300731
170STAT4_19710469_ChIP-ChIP_TH1__Mouse0.95709299
171ERG_21242973_ChIP-ChIP_JURKAT_Human0.95144972
172* SPI1_23547873_ChIP-Seq_NB4_Human0.93786243
173E2F7_22180533_ChIP-Seq_HELA_Human0.93584173
174PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.93425352
175VDR_22108803_ChIP-Seq_LS180_Human0.93127618
176NANOG_18555785_ChIP-Seq_MESCs_Mouse0.92286834
177* BCOR_27268052_Chip-Seq_Bcells_Human0.91697719
178SA1_27219007_Chip-Seq_Bcells_Human0.91394567
179* KLF4_18555785_ChIP-Seq_MESCs_Mouse0.91044469
180GATA1_26923725_Chip-Seq_HPCs_Mouse0.90860610
181AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.90496134
182IGF1R_20145208_ChIP-Seq_DFB_Human0.90136538
183MAF_26560356_Chip-Seq_TH2_Human0.89908435
184PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.89225399
185YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.88524978
186MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.88266816
187CMYC_18555785_Chip-Seq_ESCs_Mouse0.87484669
188* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.86741548
189SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.86472816
190FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86260421
191TP53_16413492_ChIP-PET_HCT116_Human0.86250890
192RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.86174627
193* P53_22387025_ChIP-Seq_ESCs_Mouse0.85851226
194* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.85842068
195PIAS1_25552417_ChIP-Seq_VCAP_Human0.85486699
196TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.85475060
197IRF8_22096565_ChIP-ChIP_GC-B_Human0.85087398

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003806_abnormal_nucleotide_metabolis6.52205810
2MP0004859_abnormal_synaptic_plasticity5.89429620
3MP0003880_abnormal_central_pattern4.83315640
4MP0002822_catalepsy4.06263582
5MP0003635_abnormal_synaptic_transmissio3.89950572
6MP0009745_abnormal_behavioral_response3.43092135
7MP0006036_abnormal_mitochondrial_physio3.31562304
8MP0004270_analgesia3.30862749
9MP0002063_abnormal_learning/memory/cond3.28239983
10MP0009046_muscle_twitch3.23654233
11MP0009379_abnormal_foot_pigmentation3.09330795
12MP0003186_abnormal_redox_activity3.02829237
13MP0002064_seizures3.02585701
14MP0001968_abnormal_touch/_nociception3.02289380
15MP0002572_abnormal_emotion/affect_behav2.75139329
16MP0002272_abnormal_nervous_system2.53201603
17MP0002734_abnormal_mechanical_nocicepti2.51890516
18MP0002736_abnormal_nociception_after2.49210097
19MP0001486_abnormal_startle_reflex2.44251380
20MP0005423_abnormal_somatic_nervous2.42193358
21MP0001529_abnormal_vocalization2.34278106
22MP0008875_abnormal_xenobiotic_pharmacok2.23578270
23MP0003787_abnormal_imprinting2.20057325
24MP0002735_abnormal_chemical_nociception2.14456337
25MP0001188_hyperpigmentation2.13723727
26MP0005671_abnormal_response_to2.07939659
27MP0009333_abnormal_splenocyte_physiolog1.96783936
28MP0002067_abnormal_sensory_capabilities1.91261833
29MP0001835_abnormal_antigen_presentation1.89654091
30MP0001440_abnormal_grooming_behavior1.87827796
31MP0001501_abnormal_sleep_pattern1.83143789
32MP0001970_abnormal_pain_threshold1.80754436
33MP0002132_abnormal_respiratory_system1.80453473
34MP0004924_abnormal_behavior1.80366660
35MP0005386_behavior/neurological_phenoty1.80366660
36MP0006035_abnormal_mitochondrial_morpho1.79062675
37MP0009785_altered_susceptibility_to1.78113953
38MP0002733_abnormal_thermal_nociception1.77483586
39MP0002148_abnormal_hypersensitivity_rea1.77017401
40MP0003075_altered_response_to1.74891635
41MP0001853_heart_inflammation1.72918151
42MP0005058_abnormal_lysosome_morphology1.72431890
43MP0008877_abnormal_DNA_methylation1.69319277
44MP0005000_abnormal_immune_tolerance1.68877075
45MP0001542_abnormal_bone_strength1.68239032
46MP0004811_abnormal_neuron_physiology1.67242264
47MP0005408_hypopigmentation1.64742903
48MP0005551_abnormal_eye_electrophysiolog1.64453652
49MP0002184_abnormal_innervation1.64372007
50MP0005409_darkened_coat_color1.63028028
51MP0002557_abnormal_social/conspecific_i1.61848715
52MP0008569_lethality_at_weaning1.58355729
53MP0001905_abnormal_dopamine_level1.56950348
54MP0000685_abnormal_immune_system1.55286753
55MP0000778_abnormal_nervous_system1.53427984
56MP0001984_abnormal_olfaction1.48092214
57MP0005646_abnormal_pituitary_gland1.46722782
58MP0009780_abnormal_chondrocyte_physiolo1.46461017
59MP0009840_abnormal_foam_cell1.46401669
60MP0005636_abnormal_mineral_homeostasis1.43503919
61MP0005451_abnormal_body_composition1.40254595
62MP0001790_abnormal_immune_system1.40034969
63MP0005387_immune_system_phenotype1.40034969
64MP0002882_abnormal_neuron_morphology1.38708614
65MP0003436_decreased_susceptibility_to1.38296310
66MP0002277_abnormal_respiratory_mucosa1.37717003
67MP0003786_premature_aging1.37352335
68MP0003123_paternal_imprinting1.37085993
69MP0006276_abnormal_autonomic_nervous1.35330231
70MP0002066_abnormal_motor_capabilities/c1.33833896
71MP0000955_abnormal_spinal_cord1.31777818
72MP0005025_abnormal_response_to1.31472216
73MP0005083_abnormal_biliary_tract1.30122336
74MP0003879_abnormal_hair_cell1.29900402
75MP0000604_amyloidosis1.29602942
76MP0002163_abnormal_gland_morphology1.28486247
77MP0005075_abnormal_melanosome_morpholog1.27646289
78MP0005332_abnormal_amino_acid1.25472193
79MP0004957_abnormal_blastocyst_morpholog1.24774035
80MP0003172_abnormal_lysosome_physiology1.22203841
81MP0008058_abnormal_DNA_repair1.20804001
82MP0002837_dystrophic_cardiac_calcinosis1.20729887
83MP0002723_abnormal_immune_serum1.19273031
84MP0004142_abnormal_muscle_tone1.18039295
85MP0000343_altered_response_to1.17662514
86MP0003122_maternal_imprinting1.17171274
87MP0000358_abnormal_cell_content/1.16918074
88MP0004147_increased_porphyrin_level1.16909460
89MP0005084_abnormal_gallbladder_morpholo1.16105167
90MP0002420_abnormal_adaptive_immunity1.15427555
91MP0008872_abnormal_physiological_respon1.15388804
92MP0002452_abnormal_antigen_presenting1.15258642
93MP0006292_abnormal_olfactory_placode1.14473211
94MP0001881_abnormal_mammary_gland1.14180893
95MP0002876_abnormal_thyroid_physiology1.12593277
96MP0001819_abnormal_immune_cell1.12580833
97MP0005166_decreased_susceptibility_to1.12471444
98MP0005165_increased_susceptibility_to1.11461605
99MP0002152_abnormal_brain_morphology1.09636547
100MP0001800_abnormal_humoral_immune1.09604745
101MP0008873_increased_physiological_sensi1.09542752
102MP0008260_abnormal_autophagy1.09282639
103MP0000678_abnormal_parathyroid_gland1.09239719
104MP0003121_genomic_imprinting1.08672984
105MP0001845_abnormal_inflammatory_respons1.06813551
106MP0002229_neurodegeneration1.05204393
107MP0004019_abnormal_vitamin_homeostasis1.04239639
108MP0003866_abnormal_defecation1.02959513
109MP0008007_abnormal_cellular_replicative1.02741858
110MP0004233_abnormal_muscle_weight1.02503317
111MP0002909_abnormal_adrenal_gland1.02074074
112MP0001986_abnormal_taste_sensitivity1.00907314
113MP0005379_endocrine/exocrine_gland_phen0.99380076
114MP0005310_abnormal_salivary_gland0.97318208
115MP0009643_abnormal_urine_homeostasis0.96431748
116MP0001502_abnormal_circadian_rhythm0.96413082
117MP0008469_abnormal_protein_level0.96012856
118MP0005394_taste/olfaction_phenotype0.95105588
119MP0005499_abnormal_olfactory_system0.95105588
120MP0003329_amyloid_beta_deposits0.94032081
121MP0005645_abnormal_hypothalamus_physiol0.93592440
122MP0006082_CNS_inflammation0.92555126
123MP0002752_abnormal_somatic_nervous0.91424875
124MP0003633_abnormal_nervous_system0.91417036
125MP0003631_nervous_system_phenotype0.90075547
126MP0005584_abnormal_enzyme/coenzyme_acti0.89623461
127MP0003191_abnormal_cellular_cholesterol0.89220717
128MP0004858_abnormal_nervous_system0.88404253
129MP0003763_abnormal_thymus_physiology0.87576703
130MP0005410_abnormal_fertilization0.87122159
131MP0001963_abnormal_hearing_physiology0.86551503
132MP0002419_abnormal_innate_immunity0.86223649
133MP0001765_abnormal_ion_homeostasis0.86058999
134MP0000631_abnormal_neuroendocrine_gland0.85971515
135MP0000490_abnormal_crypts_of0.85707350
136MP0005319_abnormal_enzyme/_coenzyme0.85432386
137MP0004885_abnormal_endolymph0.83934696
138MP0005670_abnormal_white_adipose0.82286480
139MP0005253_abnormal_eye_physiology0.81608512
140MP0002160_abnormal_reproductive_system0.80700863
141MP0002398_abnormal_bone_marrow0.80420544
142MP0003693_abnormal_embryo_hatching0.80139005
143MP0004085_abnormal_heartbeat0.79804914
144MP0006072_abnormal_retinal_apoptosis0.77630573
145MP0001756_abnormal_urination0.77129189
146MP0004215_abnormal_myocardial_fiber0.77095644
147MP0009765_abnormal_xenobiotic_induced0.76942216
148MP0000749_muscle_degeneration0.76779927
149MP0000689_abnormal_spleen_morphology0.75840735
150MP0001177_atelectasis0.75829334
151MP0001533_abnormal_skeleton_physiology0.75315080
152MP0002069_abnormal_eating/drinking_beha0.74813887
153MP0004145_abnormal_muscle_electrophysio0.74464879
154MP0002638_abnormal_pupillary_reflex0.73282405
155MP0008874_decreased_physiological_sensi0.71468742
156MP0003632_abnormal_nervous_system0.71265008
157MP0010094_abnormal_chromosome_stability0.71022697
158MP0003861_abnormal_nervous_system0.69087448
159MP0010386_abnormal_urinary_bladder0.67813456
160MP0004742_abnormal_vestibular_system0.67301239
161MP0002090_abnormal_vision0.67070405
162MP0001485_abnormal_pinna_reflex0.65569766
163MP0003698_abnormal_male_reproductive0.64449824
164MP0005171_absent_coat_pigmentation0.63917080
165MP0003646_muscle_fatigue0.63171376
166MP0000751_myopathy0.62128636
167MP0005623_abnormal_meninges_morphology0.61859060
168MP0003137_abnormal_impulse_conducting0.58354415
169MP0002751_abnormal_autonomic_nervous0.58040446
170MP0001664_abnormal_digestion0.56770939
171MP0000569_abnormal_digit_pigmentation0.56540050
172MP0002102_abnormal_ear_morphology0.56119114
173MP0004484_altered_response_of0.54971334
174MP0001943_abnormal_respiration0.54843515
175MP0003111_abnormal_nucleus_morphology0.53937152
176MP0010769_abnormal_survival0.52903692
177MP0002653_abnormal_ependyma_morphology0.52495195
178MP0003634_abnormal_glial_cell0.51890773
179MP0010770_preweaning_lethality0.51770708

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.29372540
2Myokymia (HP:0002411)6.43742403
3Focal seizures (HP:0007359)4.98991624
4Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.92537798
5Mitochondrial inheritance (HP:0001427)4.71943522
6Epileptic encephalopathy (HP:0200134)4.68711934
7Acute encephalopathy (HP:0006846)4.45484378
8Abnormal respiratory motile cilium physiology (HP:0012261)4.34551007
9Abnormal activity of mitochondrial respiratory chain (HP:0011922)4.27587184
10Decreased activity of mitochondrial respiratory chain (HP:0008972)4.27587184
11Febrile seizures (HP:0002373)4.20365043
12Abnormal respiratory motile cilium morphology (HP:0005938)4.18539885
13Abnormal respiratory epithelium morphology (HP:0012253)4.18539885
14Increased CSF lactate (HP:0002490)4.17151445
15Visual hallucinations (HP:0002367)4.15919861
16Hepatocellular necrosis (HP:0001404)4.01170843
17Atonic seizures (HP:0010819)4.00710864
18Progressive cerebellar ataxia (HP:0002073)3.98542772
19Hepatic necrosis (HP:0002605)3.90471285
20Increased hepatocellular lipid droplets (HP:0006565)3.87792855
21Absence seizures (HP:0002121)3.83473172
22Increased intramyocellular lipid droplets (HP:0012240)3.82526333
23Abnormal ciliary motility (HP:0012262)3.78223117
24Rhinitis (HP:0012384)3.73204689
25Renal Fanconi syndrome (HP:0001994)3.68523390
26Broad-based gait (HP:0002136)3.63997412
27Dynein arm defect of respiratory motile cilia (HP:0012255)3.54834053
28Absent/shortened dynein arms (HP:0200106)3.54834053
29Dialeptic seizures (HP:0011146)3.53542956
30Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.41515817
31Lipid accumulation in hepatocytes (HP:0006561)3.35330754
32Hyperventilation (HP:0002883)3.32926446
33Gaze-evoked nystagmus (HP:0000640)3.31407859
34Exercise intolerance (HP:0003546)3.28889037
35Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.26066196
36Cerebral edema (HP:0002181)3.23191778
37Increased muscle lipid content (HP:0009058)3.21499226
38Generalized tonic-clonic seizures (HP:0002069)3.17639269
39Increased serum pyruvate (HP:0003542)3.14246476
40Lactic acidosis (HP:0003128)3.11347121
413-Methylglutaconic aciduria (HP:0003535)3.03462999
42Impaired vibration sensation in the lower limbs (HP:0002166)3.00865843
43Poor eye contact (HP:0000817)3.00773826
44Dysdiadochokinesis (HP:0002075)2.94286853
45Abnormality of glycolysis (HP:0004366)2.93303298
46Chronic bronchitis (HP:0004469)2.89137215
47Truncal ataxia (HP:0002078)2.88947201
48Abnormality of the labia minora (HP:0012880)2.85862713
49Generalized aminoaciduria (HP:0002909)2.82038680
50Action tremor (HP:0002345)2.81501282
51Cerebral hypomyelination (HP:0006808)2.81123048
52Bronchiectasis (HP:0002110)2.78985295
53Respiratory failure (HP:0002878)2.77897973
54Increased serum lactate (HP:0002151)2.75829868
55Nasal polyposis (HP:0100582)2.73069330
56Anxiety (HP:0000739)2.67142077
57Depression (HP:0000716)2.58825753
58Urinary bladder sphincter dysfunction (HP:0002839)2.58734622
59Chronic sinusitis (HP:0011109)2.58434925
60Exertional dyspnea (HP:0002875)2.58412995
61Impaired smooth pursuit (HP:0007772)2.57260201
62Scanning speech (HP:0002168)2.53074798
63Genetic anticipation (HP:0003743)2.51959651
64Impaired social interactions (HP:0000735)2.51826006
65Abnormal social behavior (HP:0012433)2.51826006
66Limb dystonia (HP:0002451)2.49809159
67Abnormality of the nasal mucosa (HP:0000433)2.48423881
68Macrocytic anemia (HP:0001972)2.47670037
69Dysmetria (HP:0001310)2.47563494
70Congenital stationary night blindness (HP:0007642)2.47496893
71Excessive salivation (HP:0003781)2.44495800
72Drooling (HP:0002307)2.44495800
73Ankle clonus (HP:0011448)2.43802627
74Annular pancreas (HP:0001734)2.42106546
75Amblyopia (HP:0000646)2.37437374
76Leukodystrophy (HP:0002415)2.33202304
77Gait imbalance (HP:0002141)2.32813709
78Abnormality of placental membranes (HP:0011409)2.32568429
79Amniotic constriction ring (HP:0009775)2.32568429
80Mutism (HP:0002300)2.29449165
81Abnormality of cells of the erythroid lineage (HP:0012130)2.26456707
82Abnormality of renal resorption (HP:0011038)2.23442980
83Urinary urgency (HP:0000012)2.20592487
84Abnormality of ocular smooth pursuit (HP:0000617)2.19982003
85Abnormal hair whorl (HP:0010721)2.19315724
86Hyperphosphaturia (HP:0003109)2.18815982
87Abnormal eating behavior (HP:0100738)2.18052522
88Fetal akinesia sequence (HP:0001989)2.17130884
89Respiratory difficulties (HP:0002880)2.16488150
90Termporal pattern (HP:0011008)2.15006767
91Insidious onset (HP:0003587)2.15006767
92Progressive inability to walk (HP:0002505)2.14864320
93Inability to walk (HP:0002540)2.14862954
94Emotional lability (HP:0000712)2.14515658
95Absent speech (HP:0001344)2.14380711
96Rough bone trabeculation (HP:0100670)2.13875400
97Recurrent sinusitis (HP:0011108)2.13151941
98Bradykinesia (HP:0002067)2.11707274
99Supranuclear gaze palsy (HP:0000605)2.10607940
100Stereotypic behavior (HP:0000733)2.10495232
101Epileptiform EEG discharges (HP:0011182)2.10288390
102Resting tremor (HP:0002322)2.08754437
103Birth length less than 3rd percentile (HP:0003561)2.08453858
104Congenital ichthyosiform erythroderma (HP:0007431)2.07805941
105Torticollis (HP:0000473)2.07313359
106Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.06722294
107Abnormality of aromatic amino acid family metabolism (HP:0004338)2.05269467
108Abnormality of the lower motor neuron (HP:0002366)2.05086075
109Postural instability (HP:0002172)2.03032475
110Congenital primary aphakia (HP:0007707)2.03004154
111Central scotoma (HP:0000603)2.02909242
112Dicarboxylic aciduria (HP:0003215)2.02803926
113Abnormality of dicarboxylic acid metabolism (HP:0010995)2.02803926
114Lethargy (HP:0001254)2.02755811
115Focal dystonia (HP:0004373)2.01613604
116Dysmetric saccades (HP:0000641)2.01521232
117Spastic gait (HP:0002064)2.00222141
118Pheochromocytoma (HP:0002666)2.00108670
119Ragged-red muscle fibers (HP:0003200)2.00080855
120Medial flaring of the eyebrow (HP:0010747)1.97777741
121Glycosuria (HP:0003076)1.97120969
122Abnormality of urine glucose concentration (HP:0011016)1.97120969
123Infertility (HP:0000789)1.96669856
124Hypertensive crisis (HP:0100735)1.95745891
125Bronchitis (HP:0012387)1.95615813
126Abnormality of glycolipid metabolism (HP:0010969)1.95390188
127Abnormality of liposaccharide metabolism (HP:0010968)1.95390188
128Abnormality of glycosphingolipid metabolism (HP:0004343)1.95390188
129Hemiparesis (HP:0001269)1.94906089
130Abnormality of macular pigmentation (HP:0008002)1.94601621
131Aplastic anemia (HP:0001915)1.92952606
132Pointed chin (HP:0000307)1.92743284
133Impaired vibratory sensation (HP:0002495)1.92225601
134EEG with generalized epileptiform discharges (HP:0011198)1.92120019
135Abnormal number of erythroid precursors (HP:0012131)1.91378113
136Incomplete penetrance (HP:0003829)1.91046802
137Shoulder girdle muscle weakness (HP:0003547)1.87469496
138CNS demyelination (HP:0007305)1.87403019
139Posterior subcapsular cataract (HP:0007787)1.86712894
140Type I transferrin isoform profile (HP:0003642)1.86281813
141Abnormality of binocular vision (HP:0011514)1.86223289
142Diplopia (HP:0000651)1.86223289
143Methylmalonic acidemia (HP:0002912)1.85714333
144Protruding tongue (HP:0010808)1.84935429
145Delusions (HP:0000746)1.84667952
146Nephrogenic diabetes insipidus (HP:0009806)1.83887330
147Progressive microcephaly (HP:0000253)1.83529175
148Petechiae (HP:0000967)1.82149696
149Horizontal nystagmus (HP:0000666)1.82071183
150Hypokinesia (HP:0002375)1.81640826
151Unsteady gait (HP:0002317)1.80881067
152Acute necrotizing encephalopathy (HP:0006965)1.80842564
153Craniofacial dystonia (HP:0012179)1.80083370
154Gastroesophageal reflux (HP:0002020)1.79960922
155Reticulocytopenia (HP:0001896)1.78994913
156Progressive neurologic deterioration (HP:0002344)1.77853391
157Poor suck (HP:0002033)1.76746560
158Amyotrophic lateral sclerosis (HP:0007354)1.76548771
159Hypsarrhythmia (HP:0002521)1.75599314
160Papilledema (HP:0001085)1.75380874
161Pancytopenia (HP:0001876)1.75302333
162X-linked dominant inheritance (HP:0001423)1.75084024
163Chronic obstructive pulmonary disease (HP:0006510)1.73833081
164Obstructive lung disease (HP:0006536)1.73833081
165Testicular atrophy (HP:0000029)1.72544950
166Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.72249690
167Abnormality of alanine metabolism (HP:0010916)1.72249690
168Hyperalaninemia (HP:0003348)1.72249690
169Recurrent otitis media (HP:0000403)1.71863238
170Generalized myoclonic seizures (HP:0002123)1.71053639
171Obstructive sleep apnea (HP:0002870)1.70901291
172Neuroendocrine neoplasm (HP:0100634)1.70711729
173Opisthotonus (HP:0002179)1.69962086
174Elevated erythrocyte sedimentation rate (HP:0003565)1.69869671
175Scotoma (HP:0000575)1.69637169
176Specific learning disability (HP:0001328)1.68556548
177Agammaglobulinemia (HP:0004432)1.68526672
178Oral leukoplakia (HP:0002745)1.68253775
179Oligomenorrhea (HP:0000876)1.67565608
180Methylmalonic aciduria (HP:0012120)1.66549438
181Gait ataxia (HP:0002066)1.66113029
182Abnormality of the corticospinal tract (HP:0002492)1.66012363
183Abnormality of salivation (HP:0100755)1.64941535
184Inappropriate behavior (HP:0000719)1.61836981
185Progressive macrocephaly (HP:0004481)1.61797384
186Abnormal mitochondria in muscle tissue (HP:0008316)1.60667199
187Neoplasm of the peripheral nervous system (HP:0100007)1.60647229
188Severe visual impairment (HP:0001141)1.58235678
189Sleep apnea (HP:0010535)1.58077897
190Optic disc pallor (HP:0000543)1.56935399
191Genital tract atresia (HP:0001827)1.56769547

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA44.88161872
2NTRK34.05628945
3TESK13.68670382
4NME23.42130974
5VRK23.27074883
6CASK3.10254516
7LIMK13.07422212
8TESK22.95729140
9MST42.94508127
10STK162.90360647
11MAP3K92.85336093
12MAP3K42.72003078
13MINK12.62010483
14MAP2K72.61684434
15PIM22.61196402
16MARK12.58162992
17BCKDK2.51089397
18SCYL22.33186162
19PLK22.23722613
20RIPK42.09633384
21BUB12.06216180
22PNCK1.96654491
23DAPK21.91054273
24MAP3K121.87967052
25DAPK11.83257489
26MAP3K111.62925393
27MYLK1.62599966
28PAK61.59264979
29KSR11.57164968
30MAP3K31.54704183
31TSSK61.54446686
32PRKD31.52359177
33TAOK21.51701951
34CDK191.51693592
35MAPKAPK31.48393713
36FES1.46709947
37EIF2AK11.44182500
38ARAF1.40636255
39CCNB11.39480033
40EIF2AK31.37321587
41CDK51.35981953
42KSR21.35831717
43MAPK131.35288522
44CDC71.35149148
45NME11.34098662
46ABL21.33821374
47PBK1.31460902
48NEK11.31322041
49GRK51.29679425
50KDR1.28628096
51TNIK1.27116441
52AKT31.26910781
53CAMKK11.25575406
54TBK11.24998553
55MAP2K41.22926648
56PRKCG1.22048950
57DAPK31.21987355
58NTRK21.21228504
59PRPF4B1.20925529
60ILK1.18881449
61CDK181.17699536
62CDK141.12183310
63CDK151.10120816
64LRRK21.00814861
65STK381.00441142
66SIK30.99672654
67AURKA0.98598499
68PAK40.98030167
69CDK11A0.97637405
70PLK30.96523442
71SGK20.96170934
72PAK10.93193939
73CAMK2A0.89554407
74BRAF0.89303924
75MKNK20.86264143
76SGK2230.85426510
77SGK4940.85426510
78NTRK10.85362577
79TLK10.82447495
80CAMK2G0.81981267
81BMPR20.81560803
82PASK0.81170907
83TXK0.80011090
84IKBKE0.78939396
85PDK20.77880786
86BRSK10.77667845
87MAP2K30.77624380
88SIK20.77268117
89CAMK2B0.76223733
90PRKCI0.75573698
91RAF10.75263678
92CAMKK20.75214499
93PINK10.72673487
94PTK2B0.71831302
95GRK60.71465748
96BCR0.71289849
97TAOK10.70360414
98LATS20.69547059
99OXSR10.68673327
100DYRK1A0.67797837
101ALK0.66694722
102IKBKB0.66606068
103MAP4K10.65872652
104MOS0.65154621
105SGK10.64480971
106VRK10.63523065
107MAP3K130.62073106
108SGK30.61244449
109UHMK10.59931425
110SMG10.57796527
111PRKCD0.57594566
112CAMK10.56601225
113TYRO30.56267023
114CSNK2A20.54817554
115FGR0.53509834
116STK110.53341025
117MAP4K20.52976788
118PRKCQ0.52949459
119NEK90.49933837
120TYK20.48113470
121CSNK1G20.47593273
122PDK40.46829829
123PDK30.46829829
124CSNK2A10.46167373
125AKT20.45597416
126PHKG20.45439342
127PHKG10.45439342
128CSNK1E0.45304876
129PDK10.44393917
130SYK0.43765530
131PRKCH0.43568177
132MKNK10.43275366
133RPS6KA30.43175354
134DYRK20.41695605
135PRKCB0.40979119
136WEE10.40229870
137MAPK100.40183776
138ADRBK10.39751643
139PLK10.38810430
140CDK80.38665091
141MAPK150.38597316
142NEK60.38353824
143CSNK1G30.37842751
144PRKCE0.37439537
145CAMK2D0.35658208
146STK100.35273296
147PRKG20.34652847
148GRK70.32379666
149ROCK20.31697515
150FYN0.31278520
151FER0.31263666
152GSK3B0.31201900
153PDPK10.30535172
154PRKCA0.30243057
155LMTK20.29757119
156PRKACA0.29515027
157CSNK1A10.29496111
158CDK90.28609936
159SRPK10.26766621
160IRAK30.26403931
161MAPKAPK20.26238932
162TRIM280.25960155
163MAP3K50.25759100

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.23773970
2Nicotine addiction_Homo sapiens_hsa050333.83254577
3Synaptic vesicle cycle_Homo sapiens_hsa047213.42488576
4Olfactory transduction_Homo sapiens_hsa047403.02718092
5Long-term potentiation_Homo sapiens_hsa047202.75324174
6Phototransduction_Homo sapiens_hsa047442.66917999
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.63256635
8Protein export_Homo sapiens_hsa030602.62139506
9Amphetamine addiction_Homo sapiens_hsa050312.60547130
10Circadian entrainment_Homo sapiens_hsa047132.58273125
11GABAergic synapse_Homo sapiens_hsa047272.57677118
12Morphine addiction_Homo sapiens_hsa050322.56725951
13Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.52172274
14Glutamatergic synapse_Homo sapiens_hsa047242.39811645
15Dopaminergic synapse_Homo sapiens_hsa047282.35709885
16Salivary secretion_Homo sapiens_hsa049701.99521954
17Collecting duct acid secretion_Homo sapiens_hsa049661.86014628
18Cholinergic synapse_Homo sapiens_hsa047251.81045532
19Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.79379334
20Long-term depression_Homo sapiens_hsa047301.76697366
21Taste transduction_Homo sapiens_hsa047421.75107808
22Folate biosynthesis_Homo sapiens_hsa007901.72860892
23Renin secretion_Homo sapiens_hsa049241.70296877
24Cocaine addiction_Homo sapiens_hsa050301.68772550
25Serotonergic synapse_Homo sapiens_hsa047261.68027163
26Calcium signaling pathway_Homo sapiens_hsa040201.58876576
27Gastric acid secretion_Homo sapiens_hsa049711.58508970
282-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.58138091
29Oxytocin signaling pathway_Homo sapiens_hsa049211.55989463
30Oocyte meiosis_Homo sapiens_hsa041141.53932423
31Insulin secretion_Homo sapiens_hsa049111.51945236
32Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.51555654
33Sulfur metabolism_Homo sapiens_hsa009201.50243360
34Aldosterone synthesis and secretion_Homo sapiens_hsa049251.47802128
35Pyrimidine metabolism_Homo sapiens_hsa002401.42491531
36Fatty acid elongation_Homo sapiens_hsa000621.37253636
37Gap junction_Homo sapiens_hsa045401.34742940
38Sulfur relay system_Homo sapiens_hsa041221.34522691
39Primary immunodeficiency_Homo sapiens_hsa053401.34401168
40Glutathione metabolism_Homo sapiens_hsa004801.34247541
41Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.34200829
42Nucleotide excision repair_Homo sapiens_hsa034201.34162035
43Pyruvate metabolism_Homo sapiens_hsa006201.29646139
44Cardiac muscle contraction_Homo sapiens_hsa042601.29258140
45One carbon pool by folate_Homo sapiens_hsa006701.28186336
46Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.25156261
47GnRH signaling pathway_Homo sapiens_hsa049121.23628479
48Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.22072038
49Oxidative phosphorylation_Homo sapiens_hsa001901.20962655
50Carbon metabolism_Homo sapiens_hsa012001.18999306
51Parkinsons disease_Homo sapiens_hsa050121.18261840
52Base excision repair_Homo sapiens_hsa034101.16593781
53Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.16098488
54Vibrio cholerae infection_Homo sapiens_hsa051101.12117079
55cAMP signaling pathway_Homo sapiens_hsa040241.10253493
56Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.09362796
57Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.03068156
58Phosphatidylinositol signaling system_Homo sapiens_hsa040701.02146110
59Alzheimers disease_Homo sapiens_hsa050101.01339506
60Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.01200319
61Rheumatoid arthritis_Homo sapiens_hsa053231.00078962
62cGMP-PKG signaling pathway_Homo sapiens_hsa040220.95588951
63Glioma_Homo sapiens_hsa052140.95294098
64Huntingtons disease_Homo sapiens_hsa050160.93525376
65Peroxisome_Homo sapiens_hsa041460.92391854
66Melanogenesis_Homo sapiens_hsa049160.91582728
67Alcoholism_Homo sapiens_hsa050340.90895747
68Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.90449147
69Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.90166276
70Estrogen signaling pathway_Homo sapiens_hsa049150.90111406
71Axon guidance_Homo sapiens_hsa043600.88032364
72ErbB signaling pathway_Homo sapiens_hsa040120.87261066
73Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.85329451
74Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.82934846
75Biosynthesis of amino acids_Homo sapiens_hsa012300.82832334
76Antigen processing and presentation_Homo sapiens_hsa046120.80219155
77Vascular smooth muscle contraction_Homo sapiens_hsa042700.77147225
78Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.76955209
79Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.76542796
80Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.76500333
81Pentose phosphate pathway_Homo sapiens_hsa000300.75359167
82Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.74845454
83Metabolic pathways_Homo sapiens_hsa011000.74443386
84Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.74300456
85Shigellosis_Homo sapiens_hsa051310.70163462
86Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.69782201
87Phenylalanine metabolism_Homo sapiens_hsa003600.68312099
88Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.66813179
89Allograft rejection_Homo sapiens_hsa053300.66370807
90Regulation of autophagy_Homo sapiens_hsa041400.65295908
91Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.63178530
92Autoimmune thyroid disease_Homo sapiens_hsa053200.63008523
93Lysosome_Homo sapiens_hsa041420.61641320
94Type I diabetes mellitus_Homo sapiens_hsa049400.60789090
95MAPK signaling pathway_Homo sapiens_hsa040100.60716632
96RNA degradation_Homo sapiens_hsa030180.59510048
97Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.59490967
98Asthma_Homo sapiens_hsa053100.58371319
99Galactose metabolism_Homo sapiens_hsa000520.58182329
100Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.58134744
101Type II diabetes mellitus_Homo sapiens_hsa049300.58010244
102mRNA surveillance pathway_Homo sapiens_hsa030150.57271510
103Vitamin B6 metabolism_Homo sapiens_hsa007500.55884301
104Propanoate metabolism_Homo sapiens_hsa006400.55219570
105Fructose and mannose metabolism_Homo sapiens_hsa000510.54238992
106Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.54090942
107Homologous recombination_Homo sapiens_hsa034400.53143622
108Dilated cardiomyopathy_Homo sapiens_hsa054140.52327125
109Cysteine and methionine metabolism_Homo sapiens_hsa002700.52217102
110Proteasome_Homo sapiens_hsa030500.51720973
111Pancreatic secretion_Homo sapiens_hsa049720.51375346
112Phagosome_Homo sapiens_hsa041450.50838975
113Rap1 signaling pathway_Homo sapiens_hsa040150.50524343
114Chemical carcinogenesis_Homo sapiens_hsa052040.50458371
115Wnt signaling pathway_Homo sapiens_hsa043100.50399221
116RNA polymerase_Homo sapiens_hsa030200.50285278
117Epstein-Barr virus infection_Homo sapiens_hsa051690.49949787
118Phospholipase D signaling pathway_Homo sapiens_hsa040720.49019731
119Ras signaling pathway_Homo sapiens_hsa040140.48210760
120Intestinal immune network for IgA production_Homo sapiens_hsa046720.47627646
121Neurotrophin signaling pathway_Homo sapiens_hsa047220.47527824
122RNA transport_Homo sapiens_hsa030130.45549949
123Purine metabolism_Homo sapiens_hsa002300.45450474
124Thyroid hormone signaling pathway_Homo sapiens_hsa049190.45267243
125Glucagon signaling pathway_Homo sapiens_hsa049220.44864831
126Thyroid hormone synthesis_Homo sapiens_hsa049180.44636946
127Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.43866846
128VEGF signaling pathway_Homo sapiens_hsa043700.43266915
129Graft-versus-host disease_Homo sapiens_hsa053320.43213203
130Choline metabolism in cancer_Homo sapiens_hsa052310.41677826
131Drug metabolism - other enzymes_Homo sapiens_hsa009830.41644531
132Non-small cell lung cancer_Homo sapiens_hsa052230.40716092
133Circadian rhythm_Homo sapiens_hsa047100.39827408
134Spliceosome_Homo sapiens_hsa030400.39108193
135Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.39060281
136Sphingolipid signaling pathway_Homo sapiens_hsa040710.38193267
137beta-Alanine metabolism_Homo sapiens_hsa004100.37208116
138Cell cycle_Homo sapiens_hsa041100.36928189
139N-Glycan biosynthesis_Homo sapiens_hsa005100.36491751
140Endocytosis_Homo sapiens_hsa041440.36319341
141Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.36088995
142Tyrosine metabolism_Homo sapiens_hsa003500.34807959
143Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.33998282
144Salmonella infection_Homo sapiens_hsa051320.33791055
145Steroid biosynthesis_Homo sapiens_hsa001000.33534819
146Inositol phosphate metabolism_Homo sapiens_hsa005620.33363926
147Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.33073763
148Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.32074739
149Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.30754435
150Fatty acid degradation_Homo sapiens_hsa000710.30433949
151Colorectal cancer_Homo sapiens_hsa052100.29892009
152mTOR signaling pathway_Homo sapiens_hsa041500.28857600
153SNARE interactions in vesicular transport_Homo sapiens_hsa041300.28782092
154Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.28216945
155Renal cell carcinoma_Homo sapiens_hsa052110.28033999
156Mismatch repair_Homo sapiens_hsa034300.27928872
157Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.27877692
158Endometrial cancer_Homo sapiens_hsa052130.27645853
159Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.27394691
160Basal transcription factors_Homo sapiens_hsa030220.26908914
161Melanoma_Homo sapiens_hsa052180.26631141
162Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.26576752
163DNA replication_Homo sapiens_hsa030300.26488714
164Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.26304837
165Pentose and glucuronate interconversions_Homo sapiens_hsa000400.25180325
166Mineral absorption_Homo sapiens_hsa049780.24953616
167Viral myocarditis_Homo sapiens_hsa054160.24219564
168Arginine and proline metabolism_Homo sapiens_hsa003300.22596183
169Prion diseases_Homo sapiens_hsa050200.21492784
170Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.21329434
171Glycosaminoglycan degradation_Homo sapiens_hsa005310.15770448
172Cyanoamino acid metabolism_Homo sapiens_hsa004600.10495312

Most similar genes based on co-expression Upload to Enrichr

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