PPP1R8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene, through alternative splicing, encodes three different isoforms. Two of the protein isoforms encoded by this gene are specific inhibitors of type 1 serine/threonine protein phosphatases and can bind but not cleave RNA. The third protein isoform lacks the phosphatase inhibitory function but is a single-strand endoribonuclease comparable to RNase E of E. coli. This isoform requires magnesium for its function and cleaves specific sites in A+U-rich regions of RNA. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)6.60095605
2proline biosynthetic process (GO:0006561)6.53961201
3mitotic chromosome condensation (GO:0007076)5.83416749
4DNA deamination (GO:0045006)5.46771719
5transcription from mitochondrial promoter (GO:0006390)5.44498306
6replication fork processing (GO:0031297)5.43938729
7embryonic process involved in female pregnancy (GO:0060136)5.22935756
8maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)4.96579801
9somatic hypermutation of immunoglobulin genes (GO:0016446)4.88444181
10somatic diversification of immune receptors via somatic mutation (GO:0002566)4.88444181
11pore complex assembly (GO:0046931)4.80261062
12formation of translation preinitiation complex (GO:0001731)4.67202185
13proline metabolic process (GO:0006560)4.65552667
14telomere maintenance via semi-conservative replication (GO:0032201)4.60023331
15establishment of apical/basal cell polarity (GO:0035089)4.52348824
16mitotic G1 DNA damage checkpoint (GO:0031571)4.41981338
17DNA strand elongation involved in DNA replication (GO:0006271)4.34988701
18mitochondrial DNA metabolic process (GO:0032042)4.33264980
19regulation of translational fidelity (GO:0006450)4.26327358
20mitotic sister chromatid cohesion (GO:0007064)4.25175008
21negative regulation of mRNA splicing, via spliceosome (GO:0048025)4.25104654
22ribosomal small subunit biogenesis (GO:0042274)4.25032252
23positive regulation of protein homooligomerization (GO:0032464)4.15240963
24DNA strand elongation (GO:0022616)4.11784396
25dosage compensation (GO:0007549)4.11005073
26viral mRNA export from host cell nucleus (GO:0046784)4.10523185
27DNA strand renaturation (GO:0000733)4.05308711
28nucleotide-excision repair, DNA gap filling (GO:0006297)3.96149595
29cellular protein complex localization (GO:0034629)3.89366160
30regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.88302904
31establishment or maintenance of monopolar cell polarity (GO:0061339)3.86101706
32establishment of monopolar cell polarity (GO:0061162)3.86101706
33telomere maintenance via recombination (GO:0000722)3.85564373
34base-excision repair (GO:0006284)3.83496621
35G1 DNA damage checkpoint (GO:0044783)3.82984746
36mitotic sister chromatid segregation (GO:0000070)3.82835252
37regulation of integrin activation (GO:0033623)3.81519352
38mRNA cleavage (GO:0006379)3.80715753
39mitotic G1/S transition checkpoint (GO:0044819)3.79942551
40regulation of sister chromatid cohesion (GO:0007063)3.76242899
41oxidative demethylation (GO:0070989)3.75825109
42spliceosomal tri-snRNP complex assembly (GO:0000244)3.74977234
43protein complex localization (GO:0031503)3.73532196
44viral transcription (GO:0019083)3.73486621
45negative regulation of mRNA processing (GO:0050686)3.72100348
46meiotic chromosome segregation (GO:0045132)3.71820954
47regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.65372507
48ribosomal large subunit biogenesis (GO:0042273)3.64480384
49ribosomal small subunit assembly (GO:0000028)3.63978847
50termination of RNA polymerase II transcription (GO:0006369)3.63923177
51translational termination (GO:0006415)3.60901869
52maturation of SSU-rRNA (GO:0030490)3.60808384
53positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.58165782
54positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.58165782
55positive regulation of mitotic sister chromatid separation (GO:1901970)3.58165782
56negative regulation of RNA splicing (GO:0033119)3.57549005
57mitotic nuclear envelope disassembly (GO:0007077)3.57253994
58regulation of nucleobase-containing compound transport (GO:0032239)3.56170173
59regulation of posttranscriptional gene silencing (GO:0060147)3.55329175
60regulation of gene silencing by miRNA (GO:0060964)3.55329175
61regulation of gene silencing by RNA (GO:0060966)3.55329175
62regulation of double-strand break repair via homologous recombination (GO:0010569)3.53320222
63DNA unwinding involved in DNA replication (GO:0006268)3.53256590
64chromosome condensation (GO:0030261)3.52826588
65protein localization to kinetochore (GO:0034501)3.52692451
66histone H4-K12 acetylation (GO:0043983)3.51759034
67mitotic recombination (GO:0006312)3.51747988
68regulation of protein homooligomerization (GO:0032462)3.49756589
69maturation of 5.8S rRNA (GO:0000460)3.48727645
70DNA replication initiation (GO:0006270)3.47742712
71positive regulation of chromosome segregation (GO:0051984)3.46894391
72nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.44628576
73establishment of integrated proviral latency (GO:0075713)3.41092305
74telomere maintenance via telomere lengthening (GO:0010833)3.40436829
75regulation of RNA export from nucleus (GO:0046831)3.40300694
76kinetochore assembly (GO:0051382)3.39292029
77sister chromatid segregation (GO:0000819)3.39159607
78DNA topological change (GO:0006265)3.35947250
79metaphase plate congression (GO:0051310)3.34182897
80regulation of double-strand break repair (GO:2000779)3.33167083
81poly(A)+ mRNA export from nucleus (GO:0016973)3.32514746
82negative regulation of cell cycle arrest (GO:0071157)3.31925289
83membrane disassembly (GO:0030397)3.30649301
84nuclear envelope disassembly (GO:0051081)3.30649301
85RNA stabilization (GO:0043489)3.28795551
86mRNA stabilization (GO:0048255)3.28795551
87double-strand break repair via nonhomologous end joining (GO:0006303)3.28672148
88non-recombinational repair (GO:0000726)3.28672148
89pre-miRNA processing (GO:0031054)3.27740368
90ribosome biogenesis (GO:0042254)3.27548643
91kinetochore organization (GO:0051383)3.25661933
92histone arginine methylation (GO:0034969)3.24581290
93histone H2B ubiquitination (GO:0033523)3.24423571
94peptidyl-arginine omega-N-methylation (GO:0035247)3.23845280
95DNA double-strand break processing (GO:0000729)3.21050931
96regulation of DNA damage checkpoint (GO:2000001)3.21035222
97ribonucleoprotein complex biogenesis (GO:0022613)3.18558415
98DNA replication-dependent nucleosome assembly (GO:0006335)3.18388382
99DNA replication-dependent nucleosome organization (GO:0034723)3.18388382
100mitochondrial RNA metabolic process (GO:0000959)3.17443532
101SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.17248003
102establishment of chromosome localization (GO:0051303)3.16334127
103nucleobase-containing small molecule interconversion (GO:0015949)3.16102392
104protein targeting to ER (GO:0045047)3.12422508
105translational initiation (GO:0006413)3.10723396
106cotranslational protein targeting to membrane (GO:0006613)3.10252331
107nodal signaling pathway (GO:0038092)3.10123820
108DNA packaging (GO:0006323)3.09610127
109DNA integration (GO:0015074)3.09476847
110DNA duplex unwinding (GO:0032508)3.08931322
111negative regulation of mRNA metabolic process (GO:1903312)3.08845811
112establishment of protein localization to endoplasmic reticulum (GO:0072599)3.07625726
113DNA geometric change (GO:0032392)3.06881914
114ribosome assembly (GO:0042255)3.06786625
115translational elongation (GO:0006414)3.05608568
116establishment of protein localization to mitochondrial membrane (GO:0090151)3.05425681
117DNA conformation change (GO:0071103)3.05388813
118trophectodermal cell differentiation (GO:0001829)3.05228648
119negative regulation of JAK-STAT cascade (GO:0046426)3.03713757
120mRNA export from nucleus (GO:0006406)3.01373805
121heterochromatin organization (GO:0070828)3.01123675
122regulation of translational termination (GO:0006449)2.99134897
123mRNA transport (GO:0051028)2.98324274
124mitotic metaphase plate congression (GO:0007080)2.97657278
125folic acid-containing compound biosynthetic process (GO:0009396)2.97438851
126viral life cycle (GO:0019058)2.97021059
127regulation of mitotic spindle organization (GO:0060236)2.95892699
128protein export from nucleus (GO:0006611)2.93934189
129regulation of chromosome segregation (GO:0051983)2.93564367
130RNA export from nucleus (GO:0006405)2.93351782
131negative regulation of chromosome segregation (GO:0051985)2.91684236
132embryonic placenta development (GO:0001892)2.91344386
133COPI coating of Golgi vesicle (GO:0048205)2.91225663
134Golgi transport vesicle coating (GO:0048200)2.91225663
135cellular protein complex disassembly (GO:0043624)2.89983880
136spliceosomal snRNP assembly (GO:0000387)2.87598525
137nuclear pore organization (GO:0006999)2.87245101
138nuclear envelope organization (GO:0006998)2.86494498
139resolution of meiotic recombination intermediates (GO:0000712)2.86410104
140ATP-dependent chromatin remodeling (GO:0043044)2.85643665
141DNA replication checkpoint (GO:0000076)2.84916466
142protein localization to chromosome, centromeric region (GO:0071459)2.84652606
143regulation of chromatin binding (GO:0035561)2.84051321
144protein complex disassembly (GO:0043241)2.83983458
145protein localization to endoplasmic reticulum (GO:0070972)2.83867945
146base-excision repair, AP site formation (GO:0006285)2.82070917
147IMP metabolic process (GO:0046040)2.80302464
148IMP biosynthetic process (GO:0006188)2.72579909
149macromolecular complex disassembly (GO:0032984)2.72067758
150protein-DNA complex disassembly (GO:0032986)2.72008635
151nucleosome disassembly (GO:0006337)2.72008635
152chromosome segregation (GO:0007059)2.70096748
153regulation of early endosome to late endosome transport (GO:2000641)2.66869049
154chromatin assembly or disassembly (GO:0006333)2.66589729
155negative regulation of DNA repair (GO:0045738)2.66451855
156mRNA splicing, via spliceosome (GO:0000398)2.66077763
157RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.66077763
158regulation of spindle organization (GO:0090224)2.64552165
159CENP-A containing nucleosome assembly (GO:0034080)2.62917943
160RNA splicing, via transesterification reactions (GO:0000375)2.62755699
161regulation of mammary gland epithelial cell proliferation (GO:0033599)2.62269469
162negative regulation of histone methylation (GO:0031061)2.60806208

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.60670681
2* MYC_18555785_ChIP-Seq_MESCs_Mouse3.78279459
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.66589312
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.21267595
5MYC_19079543_ChIP-ChIP_MESCs_Mouse2.94188088
6E2F4_17652178_ChIP-ChIP_JURKAT_Human2.78425061
7SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.68761439
8FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.61868968
9MYC_18358816_ChIP-ChIP_MESCs_Mouse2.54140614
10* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.48891690
11ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.35283310
12KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.22185726
13KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.22185726
14KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.22185726
15MYC_22102868_ChIP-Seq_BL_Human2.19358448
16VDR_21846776_ChIP-Seq_THP-1_Human2.05565526
17DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.94920513
18* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.93899414
19* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.92846517
20ETS1_20019798_ChIP-Seq_JURKAT_Human1.91339535
21TP63_17297297_ChIP-ChIP_HaCaT_Human1.89899792
22POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.89688679
23XRN2_22483619_ChIP-Seq_HELA_Human1.85417195
24NANOG_18555785_ChIP-Seq_MESCs_Mouse1.83734845
25NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.80187007
26KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.79843867
27CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.78993541
28MYCN_18555785_ChIP-Seq_MESCs_Mouse1.76399232
29E2F1_18555785_ChIP-Seq_MESCs_Mouse1.74535239
30STAT3_1855785_ChIP-Seq_MESCs_Mouse1.74397901
31HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.73054076
32THAP11_20581084_ChIP-Seq_MESCs_Mouse1.71988651
33POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.70678090
34NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.70371086
35SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.69344676
36EST1_17652178_ChIP-ChIP_JURKAT_Human1.67431202
37MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.64695600
38* E2F1_21310950_ChIP-Seq_MCF-7_Human1.63073962
39GABP_19822575_ChIP-Seq_HepG2_Human1.59641168
40EGR1_19374776_ChIP-ChIP_THP-1_Human1.58943289
41CLOCK_20551151_ChIP-Seq_293T_Human1.58361182
42CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.57228798
43TCF3_18692474_ChIP-Seq_MESCs_Mouse1.56823088
44KLF4_18555785_ChIP-Seq_MESCs_Mouse1.56468062
45* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.55688277
46TCF3_18692474_ChIP-Seq_MEFs_Mouse1.55026417
47PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.54061430
48RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.53593431
49NANOG_21062744_ChIP-ChIP_HESCs_Human1.53419956
50MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.53369509
51DCP1A_22483619_ChIP-Seq_HELA_Human1.52615487
52YY1_21170310_ChIP-Seq_MESCs_Mouse1.47259315
53TTF2_22483619_ChIP-Seq_HELA_Human1.46881997
54SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.46733943
55ZFX_18555785_ChIP-Seq_MESCs_Mouse1.46412836
56* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.43276532
57SOX2_18555785_ChIP-Seq_MESCs_Mouse1.42431422
58KDM5A_27292631_Chip-Seq_BREAST_Human1.41985336
59POU5F1_16518401_ChIP-PET_MESCs_Mouse1.41402406
60CREB1_15753290_ChIP-ChIP_HEK293T_Human1.37600478
61* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.37474025
62ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.37471801
63SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.37035406
64GABP_17652178_ChIP-ChIP_JURKAT_Human1.36834059
65* VDR_23849224_ChIP-Seq_CD4+_Human1.35961657
66TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.35810580
67TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.35708204
68ERG_20887958_ChIP-Seq_HPC-7_Mouse1.31155042
69PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.31048853
70ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.30804879
71KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.30769801
72TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.29799556
73NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.29569873
74* CHD1_26751641_Chip-Seq_LNCaP_Human1.27564368
75CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.24831159
76AR_21909140_ChIP-Seq_LNCAP_Human1.24656685
77RBPJ_22232070_ChIP-Seq_NCS_Mouse1.23598627
78ESR1_15608294_ChIP-ChIP_MCF-7_Human1.23251513
79ZNF263_19887448_ChIP-Seq_K562_Human1.20204445
80* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.19967109
81CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.19880337
82FOXP3_21729870_ChIP-Seq_TREG_Human1.18195059
83TP63_19390658_ChIP-ChIP_HaCaT_Human1.17597899
84SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.17516912
85DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.15556109
86* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.15041045
87* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.14964074
88* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.14946455
89NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.14868346
90FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.14489593
91BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.14352582
92NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.14076216
93KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.14043681
94TFEB_21752829_ChIP-Seq_HELA_Human1.12655160
95NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.12573640
96SALL1_21062744_ChIP-ChIP_HESCs_Human1.12063092
97* POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.11978931
98NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.11730121
99CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.08748978
100SOX2_18692474_ChIP-Seq_MESCs_Mouse1.08384272
101ELK1_19687146_ChIP-ChIP_HELA_Human1.07871972
102SOX2_18692474_ChIP-Seq_MEFs_Mouse1.07172078
103* ELK3_25401928_ChIP-Seq_HUVEC_Human1.06572757
104P300_27058665_Chip-Seq_ZR-75-30cells_Human1.05834714
105PU.1_20513432_ChIP-Seq_Bcells_Mouse1.05155122
106OCT4_18692474_ChIP-Seq_MEFs_Mouse1.05081005
107SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.04856586
108ZFP281_18757296_ChIP-ChIP_E14_Mouse1.04700297
109SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.03949758
110NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.03307822
111SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.03284090
112HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.02959239
113* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.02609379
114SOX17_20123909_ChIP-Seq_XEN_Mouse1.02268772
115TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.02224959
116* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.01899653
117LXR_22292898_ChIP-Seq_THP-1_Human1.01881328
118CIITA_25753668_ChIP-Seq_RAJI_Human1.00020890
119KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.99025747
120TCF7_22412390_ChIP-Seq_EML_Mouse0.98632703
121* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.98034823
122KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.97797474
123ZFP281_27345836_Chip-Seq_ESCs_Mouse0.97054671
124KDM2B_26808549_Chip-Seq_DND41_Human0.96834699
125ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.95873040
126PADI4_21655091_ChIP-ChIP_MCF-7_Human0.95706186
127WT1_19549856_ChIP-ChIP_CCG9911_Human0.95583094
128SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.94397047
129TET1_21451524_ChIP-Seq_MESCs_Mouse0.94038905
130NCOR1_26117541_ChIP-Seq_K562_Human0.93671010
131ELF1_17652178_ChIP-ChIP_JURKAT_Human0.92291773
132SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.90910622
133WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.90450222

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication5.35469967
2MP0010094_abnormal_chromosome_stability3.85802475
3MP0004957_abnormal_blastocyst_morpholog3.46393538
4MP0003693_abnormal_embryo_hatching3.41903077
5MP0003111_abnormal_nucleus_morphology3.39338100
6MP0010030_abnormal_orbit_morphology3.28777773
7MP0009278_abnormal_bone_marrow3.06998480
8MP0002877_abnormal_melanocyte_morpholog3.01656479
9MP0003077_abnormal_cell_cycle2.93515689
10MP0008058_abnormal_DNA_repair2.55520631
11MP0003890_abnormal_embryonic-extraembry2.41465328
12MP0010352_gastrointestinal_tract_polyps2.29848915
13MP0008932_abnormal_embryonic_tissue2.29436436
14MP0004233_abnormal_muscle_weight2.27999986
15MP0005171_absent_coat_pigmentation2.26320946
16MP0003786_premature_aging2.18060377
17MP0005076_abnormal_cell_differentiation2.12074071
18MP0008877_abnormal_DNA_methylation2.09006202
19MP0005451_abnormal_body_composition2.08452731
20MP0002009_preneoplasia2.06581500
21MP0010234_abnormal_vibrissa_follicle2.05956246
22MP0002653_abnormal_ependyma_morphology2.04240155
23MP0000350_abnormal_cell_proliferation2.04168144
24MP0001730_embryonic_growth_arrest2.00548459
25MP0004185_abnormal_adipocyte_glucose1.94375782
26MP0009379_abnormal_foot_pigmentation1.89542996
27* MP0002084_abnormal_developmental_patter1.88634269
28MP0003119_abnormal_digestive_system1.88331460
29* MP0001697_abnormal_embryo_size1.88106309
30MP0001545_abnormal_hematopoietic_system1.87546976
31MP0005397_hematopoietic_system_phenotyp1.87546976
32* MP0002085_abnormal_embryonic_tissue1.84311988
33MP0001672_abnormal_embryogenesis/_devel1.82116003
34MP0005380_embryogenesis_phenotype1.82116003
35MP0008995_early_reproductive_senescence1.81096606
36MP0010307_abnormal_tumor_latency1.80789736
37* MP0002086_abnormal_extraembryonic_tissu1.79269778
38MP0005623_abnormal_meninges_morphology1.78564509
39MP0004197_abnormal_fetal_growth/weight/1.77401478
40MP0000490_abnormal_crypts_of1.75052619
41MP0008007_abnormal_cellular_replicative1.74113765
42MP0004133_heterotaxia1.71334369
43MP0001293_anophthalmia1.71052212
44MP0005257_abnormal_intraocular_pressure1.70831440
45MP0003283_abnormal_digestive_organ1.57440481
46MP0003567_abnormal_fetal_cardiomyocyte1.52774647
47MP0003984_embryonic_growth_retardation1.52490696
48* MP0002080_prenatal_lethality1.51152155
49MP0002088_abnormal_embryonic_growth/wei1.48042930
50MP0009672_abnormal_birth_weight1.44251767
51MP0000537_abnormal_urethra_morphology1.41739817
52MP0002019_abnormal_tumor_incidence1.34787050
53MP0000428_abnormal_craniofacial_morphol1.34714046
54MP0003123_paternal_imprinting1.33136113
55MP0002249_abnormal_larynx_morphology1.32764503
56MP0002396_abnormal_hematopoietic_system1.32511697
57MP0005174_abnormal_tail_pigmentation1.27485812
58MP0000313_abnormal_cell_death1.26237181
59MP0008438_abnormal_cutaneous_collagen1.24899387
60MP0003941_abnormal_skin_development1.24122850
61MP0002111_abnormal_tail_morphology1.20225055
62MP0001849_ear_inflammation1.18561309
63MP0006072_abnormal_retinal_apoptosis1.18332797
64MP0003718_maternal_effect1.17296990
65MP0003091_abnormal_cell_migration1.12427157
66MP0002282_abnormal_trachea_morphology1.12074321
67MP0003385_abnormal_body_wall1.08773051
68MP0004272_abnormal_basement_membrane1.04746021
69MP0009053_abnormal_anal_canal1.04111585
70MP0000371_diluted_coat_color1.04051726
71MP0009333_abnormal_splenocyte_physiolog1.02658095
72MP0003453_abnormal_keratinocyte_physiol1.02540254
73MP0003705_abnormal_hypodermis_morpholog1.01939413
74MP0000733_abnormal_muscle_development1.00495593
75MP0002932_abnormal_joint_morphology0.98567221
76MP0001145_abnormal_male_reproductive0.97586252
77MP0005075_abnormal_melanosome_morpholog0.96551402
78MP0002060_abnormal_skin_morphology0.96441194
79MP0001346_abnormal_lacrimal_gland0.96186634
80MP0005384_cellular_phenotype0.95624238
81MP0000358_abnormal_cell_content/0.94805044
82MP0003935_abnormal_craniofacial_develop0.93987103
83MP0002796_impaired_skin_barrier0.92010469
84MP0002210_abnormal_sex_determination0.91903303
85MP0002269_muscular_atrophy0.89777398
86MP0001286_abnormal_eye_development0.88834240
87MP0003300_gastrointestinal_ulcer0.88446980
88MP0005409_darkened_coat_color0.87030437
89MP0002114_abnormal_axial_skeleton0.86588400
90MP0003315_abnormal_perineum_morphology0.86571389
91MP0002075_abnormal_coat/hair_pigmentati0.86239304
92MP0003755_abnormal_palate_morphology0.84300649
93MP0004264_abnormal_extraembryonic_tissu0.83730053
94MP0001216_abnormal_epidermal_layer0.83075047
95MP0004808_abnormal_hematopoietic_stem0.82969907
96MP0005666_abnormal_adipose_tissue0.82472762
97MP0000703_abnormal_thymus_morphology0.81943002
98MP0000470_abnormal_stomach_morphology0.81686534
99MP0010630_abnormal_cardiac_muscle0.80847442
100MP0005197_abnormal_uvea_morphology0.80153913
101MP0003937_abnormal_limbs/digits/tail_de0.79007222
102MP0000432_abnormal_head_morphology0.78527623
103MP0003566_abnormal_cell_adhesion0.78087056
104MP0002092_abnormal_eye_morphology0.77890288
105MP0003942_abnormal_urinary_system0.74913555
106MP0000689_abnormal_spleen_morphology0.74264824
107MP0000653_abnormal_sex_gland0.72837992
108MP0000477_abnormal_intestine_morphology0.72663807
109MP0003950_abnormal_plasma_membrane0.72129019
110MP0005058_abnormal_lysosome_morphology0.71871432
111MP0002116_abnormal_craniofacial_bone0.71255865
112MP0005248_abnormal_Harderian_gland0.71246619
113MP0001915_intracranial_hemorrhage0.70781781
114MP0003303_peritoneal_inflammation0.70508831
115MP0003115_abnormal_respiratory_system0.69860019
116MP0009703_decreased_birth_body0.69811609
117MP0000858_altered_metastatic_potential0.69665143
118MP0002697_abnormal_eye_size0.69397583
119MP0005023_abnormal_wound_healing0.69338483
120MP0001348_abnormal_lacrimal_gland0.68949823
121MP0006292_abnormal_olfactory_placode0.68760857
122MP0001929_abnormal_gametogenesis0.68153762
123MP0003763_abnormal_thymus_physiology0.67765996
124MP0000015_abnormal_ear_pigmentation0.67558838
125MP0002722_abnormal_immune_system0.66660969
126MP0003656_abnormal_erythrocyte_physiolo0.66032983
127MP0002398_abnormal_bone_marrow0.65394565
128MP0005408_hypopigmentation0.65087205
129MP0000377_abnormal_hair_follicle0.65072050
130MP0003861_abnormal_nervous_system0.64453450
131MP0005193_abnormal_anterior_eye0.64413117
132MP0001186_pigmentation_phenotype0.63834765
133MP0002925_abnormal_cardiovascular_devel0.62519801
134MP0001340_abnormal_eyelid_morphology0.62203673
135MP0003172_abnormal_lysosome_physiology0.62088730
136MP0005266_abnormal_metabolism0.61895281
137MP0003221_abnormal_cardiomyocyte_apopto0.61391803
138MP0003121_genomic_imprinting0.60885333
139MP0000049_abnormal_middle_ear0.60240383
140MP0008770_decreased_survivor_rate0.60102280
141MP0005501_abnormal_skin_physiology0.58993791
142MP0003828_pulmonary_edema0.58863910
143MP0005621_abnormal_cell_physiology0.58161405

Predicted human phenotypes

RankGene SetZ-score
1Rib fusion (HP:0000902)4.95540690
2Facial hemangioma (HP:0000329)4.48799162
3Annular pancreas (HP:0001734)4.02234890
4Rectal fistula (HP:0100590)3.90957113
5Rectovaginal fistula (HP:0000143)3.90957113
6Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.74472895
7Poikiloderma (HP:0001029)3.74314991
8Intestinal fistula (HP:0100819)3.67002453
9Patellar aplasia (HP:0006443)3.66069118
10Selective tooth agenesis (HP:0001592)3.59745542
11Concave nail (HP:0001598)3.52328836
12Aplasia/hypoplasia of the humerus (HP:0006507)3.49456373
13Aplasia/Hypoplasia of the patella (HP:0006498)3.47502271
14Short humerus (HP:0005792)3.42516342
15Vaginal fistula (HP:0004320)3.39391230
16Absent radius (HP:0003974)3.35786962
17Absent thumb (HP:0009777)3.35562490
18Ulnar bowing (HP:0003031)3.33075885
19Basal cell carcinoma (HP:0002671)3.31878921
20Pustule (HP:0200039)3.30612642
21Progressive external ophthalmoplegia (HP:0000590)3.26400075
22Tongue fasciculations (HP:0001308)3.24756449
23Abnormality of the labia minora (HP:0012880)3.21936341
24Aplasia involving forearm bones (HP:0009822)3.14993568
25Absent forearm bone (HP:0003953)3.14993568
26Ependymoma (HP:0002888)3.11999289
27Increased nuchal translucency (HP:0010880)3.00004662
28Astrocytoma (HP:0009592)2.99356604
29Abnormality of the astrocytes (HP:0100707)2.99356604
30Orthostatic hypotension (HP:0001278)2.97779550
31Squamous cell carcinoma (HP:0002860)2.97062039
32Muscle fibrillation (HP:0010546)2.96514984
33Hypochromic microcytic anemia (HP:0004840)2.90103913
34Progressive muscle weakness (HP:0003323)2.85777519
35Broad alveolar ridges (HP:0000187)2.84712735
36Volvulus (HP:0002580)2.83651365
37Intestinal atresia (HP:0011100)2.81781861
38Premature graying of hair (HP:0002216)2.76395139
39Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.74735024
40Vertebral hypoplasia (HP:0008417)2.74735024
41Increased IgM level (HP:0003496)2.72594242
42Ankyloglossia (HP:0010296)2.69432123
43Capillary hemangiomas (HP:0005306)2.67851919
44Hyperacusis (HP:0010780)2.64357171
45Abnormality of the ileum (HP:0001549)2.64132251
46Insomnia (HP:0100785)2.61462466
47Alopecia of scalp (HP:0002293)2.61056011
48Overlapping toe (HP:0001845)2.59848111
49Abnormal number of incisors (HP:0011064)2.58443334
50Turricephaly (HP:0000262)2.56313869
51Aplasia/Hypoplasia of the sacrum (HP:0008517)2.55267214
52Medulloblastoma (HP:0002885)2.52838984
53Abnormality of the phalanges of the hallux (HP:0010057)2.52460891
54Cortical dysplasia (HP:0002539)2.51914147
55Congenital hip dislocation (HP:0001374)2.50476505
56Breast hypoplasia (HP:0003187)2.48181099
57Multiple enchondromatosis (HP:0005701)2.47967031
58Neoplasm of the oral cavity (HP:0100649)2.46200386
59Male infertility (HP:0003251)2.44135724
60Birth length less than 3rd percentile (HP:0003561)2.39261161
61Deep philtrum (HP:0002002)2.37711830
62Glioma (HP:0009733)2.37481087
63Abnormal hemoglobin (HP:0011902)2.36871384
64Acute lymphatic leukemia (HP:0006721)2.36059833
65Insidious onset (HP:0003587)2.32990143
66Termporal pattern (HP:0011008)2.32990143
67Vertebral fusion (HP:0002948)2.32169038
68Abnormality of male internal genitalia (HP:0000022)2.31829053
69Premature rupture of membranes (HP:0001788)2.31797664
70Deviation of the thumb (HP:0009603)2.29086133
71Short chin (HP:0000331)2.28116399
72Coronal craniosynostosis (HP:0004440)2.26645320
73Asymmetry of the thorax (HP:0001555)2.25836453
74Rhabdomyosarcoma (HP:0002859)2.24985360
75Short 5th finger (HP:0009237)2.24022403
76Colon cancer (HP:0003003)2.23627174
77Proximal placement of thumb (HP:0009623)2.22368801
78Abnormality of the aortic arch (HP:0012303)2.21986629
79Anteriorly placed anus (HP:0001545)2.18718883
80Leiomyosarcoma (HP:0100243)2.17721928
81Uterine leiomyosarcoma (HP:0002891)2.17721928
82Microvesicular hepatic steatosis (HP:0001414)2.15719192
83Hypoplasia of the radius (HP:0002984)2.15305483
84Protrusio acetabuli (HP:0003179)2.14875088
85Hypotelorism (HP:0000601)2.13892887
86Short thumb (HP:0009778)2.11640602
87Missing ribs (HP:0000921)2.10731664
88Abnormality of oral frenula (HP:0000190)2.10565839
89Back pain (HP:0003418)2.08666006
90Dysautonomia (HP:0002459)2.08193126
91Macrocytic anemia (HP:0001972)2.06955328
92Hypochromic anemia (HP:0001931)2.06375249
93Spinal muscular atrophy (HP:0007269)2.04755062
94Degeneration of anterior horn cells (HP:0002398)2.04533830
95Abnormality of the anterior horn cell (HP:0006802)2.04533830
96Duplication of thumb phalanx (HP:0009942)2.03596577
97Abnormality of the distal phalanx of the thumb (HP:0009617)2.02454402
98Embryonal renal neoplasm (HP:0011794)2.02175532
99Spastic diplegia (HP:0001264)2.01664790
100Hemivertebrae (HP:0002937)2.01567267
101Aplasia/Hypoplasia of the 5th finger (HP:0006262)2.00976396
102Albinism (HP:0001022)2.00768303
103Trismus (HP:0000211)1.99186216
104Cerebral aneurysm (HP:0004944)1.97843407
105Renal duplication (HP:0000075)1.96392603
106Myelodysplasia (HP:0002863)1.94935175
107Bowed forearm bones (HP:0003956)1.94847223
108Bowing of the arm (HP:0006488)1.94847223
109Abnormality of the lower motor neuron (HP:0002366)1.94485243
110Gastrointestinal atresia (HP:0002589)1.94134756
111High anterior hairline (HP:0009890)1.93647628
112Aplasia/Hypoplasia of the uvula (HP:0010293)1.93059906
113Overriding aorta (HP:0002623)1.91542653
114Chromosomal breakage induced by crosslinking agents (HP:0003221)1.90197064
115Abnormality of abdominal situs (HP:0011620)1.89373503
116Abdominal situs inversus (HP:0003363)1.89373503
117Gastrointestinal carcinoma (HP:0002672)1.88751719
118Malignant gastrointestinal tract tumors (HP:0006749)1.88751719
119Neoplasm of striated muscle (HP:0009728)1.88737680
120Abnormality of reticulocytes (HP:0004312)1.88322362
12111 pairs of ribs (HP:0000878)1.88245869
122Atresia of the external auditory canal (HP:0000413)1.88001194
123Meckel diverticulum (HP:0002245)1.87592546
124Disproportionate tall stature (HP:0001519)1.87321248
125Microglossia (HP:0000171)1.87147125
126Deep palmar crease (HP:0006191)1.87107893
127Long eyelashes (HP:0000527)1.86534610
128Glossoptosis (HP:0000162)1.85900346
129Alacrima (HP:0000522)1.85210264
130Increased number of teeth (HP:0011069)1.85086842
131Spinal cord lesions (HP:0100561)1.84401053
132Syringomyelia (HP:0003396)1.84401053
133Pseudobulbar signs (HP:0002200)1.83982868
134Achilles tendon contracture (HP:0001771)1.83961490
135IgA deficiency (HP:0002720)1.82766226
136Cafe-au-lait spot (HP:0000957)1.82745082
137Short middle phalanx of the 5th finger (HP:0004220)1.82577468
138Nephroblastoma (Wilms tumor) (HP:0002667)1.81766124
139Transitional cell carcinoma of the bladder (HP:0006740)1.81430474
140Agnosia (HP:0010524)1.80849585
141Chromsome breakage (HP:0040012)1.80729567
142Pallor (HP:0000980)1.80601336
143Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.80280536
144Aplasia cutis congenita (HP:0001057)1.79282496
145Septate vagina (HP:0001153)1.78997928
146Reticulocytopenia (HP:0001896)1.78540218
147Broad thumb (HP:0011304)1.78422313
148Relative macrocephaly (HP:0004482)1.77924983
149Shoulder girdle muscle weakness (HP:0003547)1.76632781
150Hamartoma (HP:0010566)1.75778507
151Carpal bone hypoplasia (HP:0001498)1.75651079
152Pancreatic islet-cell hyperplasia (HP:0004510)1.75258457
153Abnormality of cells of the erythroid lineage (HP:0012130)1.75026642
154Shawl scrotum (HP:0000049)1.74272677
155Supernumerary spleens (HP:0009799)1.73607708
156Abnormality of the preputium (HP:0100587)1.71512875
157Upper motor neuron abnormality (HP:0002127)1.70526069
158Natal tooth (HP:0000695)1.69766237
159Abnormality of the calcaneus (HP:0008364)1.69284720
160Abnormality of the umbilical cord (HP:0010881)1.68065486
161Abnormal number of erythroid precursors (HP:0012131)1.67927123
162Patellar dislocation (HP:0002999)1.67925878
163Abnormality of chromosome segregation (HP:0002916)1.67871179
164Abnormal umbilical cord blood vessels (HP:0011403)1.67405932
165Single umbilical artery (HP:0001195)1.67405932
166Abnormality of the fetal cardiovascular system (HP:0010948)1.67405932
167Dysmetric saccades (HP:0000641)1.67378110
168Renal cell carcinoma (HP:0005584)1.66477657
169Arnold-Chiari malformation (HP:0002308)1.65398111
170Bladder carcinoma (HP:0002862)1.64645799
171Bladder neoplasm (HP:0009725)1.64645799
172Cubitus valgus (HP:0002967)1.62230032
173Pelvic girdle muscle weakness (HP:0003749)1.61790875
174Bowel incontinence (HP:0002607)1.61453577
175Acute myeloid leukemia (HP:0004808)1.60110960
176Abnormality of the salivary glands (HP:0010286)1.59786487
177Abnormal large intestine physiology (HP:0012700)1.59638163
178Abnormality of chromosome stability (HP:0003220)1.58677752
179Obsessive-compulsive behavior (HP:0000722)1.57103394
180Abnormal cartilage morphology (HP:0002763)1.56745766
181Abnormality of cochlea (HP:0000375)1.56504572
182Breech presentation (HP:0001623)1.55986001
183Radioulnar synostosis (HP:0002974)1.55298950
184Long palpebral fissure (HP:0000637)1.52854302
185Abnormality of the Achilles tendon (HP:0005109)1.51547818

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ICK4.60679230
2DDR23.71883610
3MAP3K63.36138358
4SMG12.82215777
5MAP3K112.81770479
6MAPK152.75551444
7CDC72.56626556
8BUB12.46276190
9TYRO32.41519956
10MATK2.34512834
11WEE12.28051437
12CDK72.27560339
13PINK12.26426180
14CDK122.16234398
15FGR2.04048430
16NEK21.95268354
17KSR21.94003405
18MAP3K101.93573695
19DAPK11.92699101
20PIM21.91728954
21BMX1.78594090
22IRAK31.76299482
23PDGFRA1.72217217
24UHMK11.67788586
25PLK11.66127460
26CHEK21.61922426
27PRKD21.59672334
28PIM11.57548618
29DYRK31.54928604
30LATS21.53953795
31PBK1.52150337
32CDK61.51589176
33DYRK1B1.49475244
34YES11.48733453
35CSK1.40441378
36ACVR1B1.33445907
37RPS6KB21.33080934
38ATR1.31030907
39NEK11.30381883
40PLK41.26512073
41TAF11.22258755
42NEK91.19357422
43TTK1.17275132
44SRPK11.17142333
45EEF2K1.14285142
46ALK1.11109169
47BRAF1.10712288
48EPHA21.07031874
49TESK21.06618404
50RPS6KC11.05396099
51RPS6KL11.05396099
52AURKB1.04982094
53BRSK21.04178767
54SIK11.02696782
55CDK41.02219789
56KSR11.02206627
57FGFR41.00683622
58CHEK10.99662508
59TLK10.96111625
60MTOR0.93677120
61TRPM70.92264737
62PNCK0.90987160
63RPS6KA60.90890497
64CDK20.90529783
65AKT30.89577116
66MAPK110.88346568
67STK240.87515086
68STK100.87452926
69CLK10.86380356
70AURKA0.86369349
71TRIB30.86304049
72CAMK1D0.84186612
73TAOK20.83050329
74CCNB10.81159220
75CAMK1G0.81017611
76MKNK10.77987025
77PAK40.77041074
78MAP3K80.76418421
79CDC42BPA0.76193925
80MAP3K140.76109273
81NME20.75656557
82BRSK10.74984480
83MAP3K90.74649035
84STK160.73235873
85ATM0.68381246
86MKNK20.68039190
87LRRK20.67990617
88GSK3A0.66779488
89FLT30.66498903
90RPS6KA10.65986598
91MAP3K130.61042273
92EIF2AK10.58462336
93IRAK20.58257495
94ARAF0.57492272
95TGFBR10.57270478
96STK30.56688463
97PASK0.56413516
98TSSK60.56404828
99DMPK0.55789497
100CDK10.55297300
101STK40.54767458
102SCYL20.54365941
103PTK60.53642880
104RAF10.53557665
105HIPK20.52850787
106* CSNK2A10.51017128
107MAP2K30.50613776
108PKN20.48057373
109CDK11A0.47402839
110* CSNK2A20.46778185
111TTN0.46246931
112MOS0.46154086
113PAK10.45318721
114RPS6KA40.44619724
115PRPF4B0.43177179
116CDK90.42800614
117MAP3K20.42723350
118EIF2AK30.40522183
119MAPK140.40239059
120CSNK1E0.39919980
121RPS6KB10.39746087
122CDK150.37747543
123MAPK10.37457929
124PRKAA10.37195612
125LATS10.36323882
126CDK30.35438304
127PRKCI0.34762870
128BRD40.33837981
129GRK60.33826118
130MAP4K10.33613908
131CDK180.33563515
132VRK10.33518907
133PLK30.33478018
134AKT20.33366263
135MELK0.32244747
136PAK20.31046423
137CDK80.31018454

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034304.98319447
2DNA replication_Homo sapiens_hsa030304.88284066
3Base excision repair_Homo sapiens_hsa034104.18032229
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.34049415
5Spliceosome_Homo sapiens_hsa030403.12733918
6RNA transport_Homo sapiens_hsa030133.02009751
7Nucleotide excision repair_Homo sapiens_hsa034202.84175188
8Cell cycle_Homo sapiens_hsa041102.59287261
9Homologous recombination_Homo sapiens_hsa034402.58649401
10Fatty acid biosynthesis_Homo sapiens_hsa000612.39874038
11mRNA surveillance pathway_Homo sapiens_hsa030152.28399628
12Fanconi anemia pathway_Homo sapiens_hsa034602.22609175
13Ribosome_Homo sapiens_hsa030102.10762932
14One carbon pool by folate_Homo sapiens_hsa006701.99096613
15p53 signaling pathway_Homo sapiens_hsa041151.86761276
16RNA polymerase_Homo sapiens_hsa030201.70149132
17Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.61303474
18Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.56984111
19Notch signaling pathway_Homo sapiens_hsa043301.48418177
20Proteasome_Homo sapiens_hsa030501.44224888
21Hippo signaling pathway_Homo sapiens_hsa043901.42800772
22mTOR signaling pathway_Homo sapiens_hsa041501.42322222
23Pyrimidine metabolism_Homo sapiens_hsa002401.34902458
24RNA degradation_Homo sapiens_hsa030181.33745788
25Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.33199569
26Hedgehog signaling pathway_Homo sapiens_hsa043401.30281436
27Renal cell carcinoma_Homo sapiens_hsa052111.28594596
28Biosynthesis of amino acids_Homo sapiens_hsa012301.28584956
29Basal transcription factors_Homo sapiens_hsa030221.26081909
30Sulfur relay system_Homo sapiens_hsa041221.24768056
31Oocyte meiosis_Homo sapiens_hsa041141.23191932
32Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.23043117
33Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.17010834
34Transcriptional misregulation in cancer_Homo sapiens_hsa052021.13956458
35Viral carcinogenesis_Homo sapiens_hsa052031.10005429
36Basal cell carcinoma_Homo sapiens_hsa052171.09707750
37Adherens junction_Homo sapiens_hsa045201.04796303
38Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.03808260
39Bladder cancer_Homo sapiens_hsa052191.02048029
40TGF-beta signaling pathway_Homo sapiens_hsa043501.01788614
41Non-homologous end-joining_Homo sapiens_hsa034501.01142790
42Glioma_Homo sapiens_hsa052140.98432474
43MicroRNAs in cancer_Homo sapiens_hsa052060.97288610
44Prion diseases_Homo sapiens_hsa050200.97065386
45Colorectal cancer_Homo sapiens_hsa052100.96293307
46Epstein-Barr virus infection_Homo sapiens_hsa051690.94519002
47AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.93146915
48Folate biosynthesis_Homo sapiens_hsa007900.93034495
49Systemic lupus erythematosus_Homo sapiens_hsa053220.92249129
50Circadian rhythm_Homo sapiens_hsa047100.91186693
51Carbon metabolism_Homo sapiens_hsa012000.89929037
52Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.88484296
53Thyroid cancer_Homo sapiens_hsa052160.84149928
542-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.82666698
55Wnt signaling pathway_Homo sapiens_hsa043100.82507681
56Herpes simplex infection_Homo sapiens_hsa051680.82389167
57Shigellosis_Homo sapiens_hsa051310.81081646
58Neurotrophin signaling pathway_Homo sapiens_hsa047220.79263799
59Chronic myeloid leukemia_Homo sapiens_hsa052200.79062310
60Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.78265327
61Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.77839745
62Arginine and proline metabolism_Homo sapiens_hsa003300.77549595
63HTLV-I infection_Homo sapiens_hsa051660.76909151
64Small cell lung cancer_Homo sapiens_hsa052220.76890144
65Longevity regulating pathway - mammal_Homo sapiens_hsa042110.73919715
66Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.72373275
67Lysine degradation_Homo sapiens_hsa003100.72124230
68Primary immunodeficiency_Homo sapiens_hsa053400.71967826
69Protein export_Homo sapiens_hsa030600.68628091
70Prolactin signaling pathway_Homo sapiens_hsa049170.64295367
71Vitamin B6 metabolism_Homo sapiens_hsa007500.62444683
72Acute myeloid leukemia_Homo sapiens_hsa052210.61571816
73Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.58918080
74Fructose and mannose metabolism_Homo sapiens_hsa000510.58049425
75Pyruvate metabolism_Homo sapiens_hsa006200.56911028
76Legionellosis_Homo sapiens_hsa051340.56546787
77Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.55258913
78VEGF signaling pathway_Homo sapiens_hsa043700.54510277
79Inositol phosphate metabolism_Homo sapiens_hsa005620.54081581
80Central carbon metabolism in cancer_Homo sapiens_hsa052300.53457802
81Selenocompound metabolism_Homo sapiens_hsa004500.51093785
82Focal adhesion_Homo sapiens_hsa045100.50795838
83Steroid biosynthesis_Homo sapiens_hsa001000.50021581
84Viral myocarditis_Homo sapiens_hsa054160.49193708
85Melanoma_Homo sapiens_hsa052180.48876697
86Influenza A_Homo sapiens_hsa051640.47928258
87Purine metabolism_Homo sapiens_hsa002300.45693068
88Cysteine and methionine metabolism_Homo sapiens_hsa002700.45098973
89Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.44517156
90Hepatitis B_Homo sapiens_hsa051610.44114738
91Tight junction_Homo sapiens_hsa045300.43684114
92Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.43280014
93FoxO signaling pathway_Homo sapiens_hsa040680.43049530
94Endometrial cancer_Homo sapiens_hsa052130.42684063
95Choline metabolism in cancer_Homo sapiens_hsa052310.42194205
96Antigen processing and presentation_Homo sapiens_hsa046120.39923615
97Cyanoamino acid metabolism_Homo sapiens_hsa004600.39876479
98Hepatitis C_Homo sapiens_hsa051600.39383046
99Regulation of actin cytoskeleton_Homo sapiens_hsa048100.39103936
100Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.38649635
101Pathways in cancer_Homo sapiens_hsa052000.38495576
102Estrogen signaling pathway_Homo sapiens_hsa049150.37896842
103Alcoholism_Homo sapiens_hsa050340.37824780
104Proteoglycans in cancer_Homo sapiens_hsa052050.36778745
105Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.35530691
106N-Glycan biosynthesis_Homo sapiens_hsa005100.35500564
107Pentose phosphate pathway_Homo sapiens_hsa000300.34447367
108Apoptosis_Homo sapiens_hsa042100.33668603
109AMPK signaling pathway_Homo sapiens_hsa041520.33178346
110HIF-1 signaling pathway_Homo sapiens_hsa040660.33033064
111Non-small cell lung cancer_Homo sapiens_hsa052230.32505252
112Galactose metabolism_Homo sapiens_hsa000520.31898106
113Pancreatic cancer_Homo sapiens_hsa052120.30867169
114Prostate cancer_Homo sapiens_hsa052150.29406449
115Insulin signaling pathway_Homo sapiens_hsa049100.28186754
116Measles_Homo sapiens_hsa051620.26068720
117Thyroid hormone signaling pathway_Homo sapiens_hsa049190.25936632
118PI3K-Akt signaling pathway_Homo sapiens_hsa041510.25093480
119Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.24659181
120Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.22728070
121ErbB signaling pathway_Homo sapiens_hsa040120.22078820
122Glutathione metabolism_Homo sapiens_hsa004800.19340801
123Gap junction_Homo sapiens_hsa045400.17575626
124B cell receptor signaling pathway_Homo sapiens_hsa046620.16018293
125Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.15973180

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