ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	regulation of odontogenesis of dentin-containing tooth (GO:0042487)	9.30249045
2	lipopolysaccharide biosynthetic process (GO:0009103)	8.69563375
3	protein-chromophore linkage (GO:0018298)	8.57630036
4	DNA methylation involved in gamete generation (GO:0043046)	8.26113299
5	regulation of meiosis I (GO:0060631)	7.86970505
6	negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)	7.63196198
7	lipopolysaccharide metabolic process (GO:0008653)	7.62724274
8	regulation of protein glycosylation (GO:0060049)	7.27677144
9	paraxial mesoderm development (GO:0048339)	7.27544027
10	regulation of pigment cell differentiation (GO:0050932)	7.02749463
11	negative regulation of glycoprotein biosynthetic process (GO:0010561)	7.01475857
12	positive regulation of developmental pigmentation (GO:0048087)	7.00150553
13	sulfate transmembrane transport (GO:1902358)	6.96746243
14	negative regulation of cell cycle G2/M phase transition (GO:1902750)	6.71580438
15	regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)	6.39820311
16	tachykinin receptor signaling pathway (GO:0007217)	6.37751373
17	sulfate transport (GO:0008272)	5.88516280
18	piRNA metabolic process (GO:0034587)	5.84176588
19	erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)	5.59988469
20	L-phenylalanine catabolic process (GO:0006559)	5.59988469
21	notochord development (GO:0030903)	5.45159320
22	SMAD protein complex assembly (GO:0007183)	5.44884210
23	ribonucleoprotein complex disassembly (GO:0032988)	5.32514807
24	negative regulation of glycoprotein metabolic process (GO:1903019)	5.18159398
25	tyrosine metabolic process (GO:0006570)	5.04226573
26	centriole replication (GO:0007099)	4.95784037
27	heme transport (GO:0015886)	4.94478867
28	L-phenylalanine metabolic process (GO:0006558)	4.73747334
29	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	4.73747334
30	gamma-aminobutyric acid signaling pathway (GO:0007214)	4.64717565
31	regulation of transforming growth factor beta2 production (GO:0032909)	4.42782948
32	positive regulation of meiosis (GO:0045836)	4.34175939
33	serotonin receptor signaling pathway (GO:0007210)	4.31751298
34	organelle disassembly (GO:1903008)	4.29626398
35	nodal signaling pathway (GO:0038092)	4.25901809
36	negative regulation of stem cell proliferation (GO:2000647)	4.21245188
37	meiotic chromosome segregation (GO:0045132)	4.20653118
38	glycerol metabolic process (GO:0006071)	4.11447747
39	regulation of odontogenesis (GO:0042481)	4.07140628
40	positive regulation of meiotic cell cycle (GO:0051446)	4.01560931
41	epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)	3.94460032
42	vitamin transmembrane transport (GO:0035461)	3.94285063
43	regulation of interleukin-5 production (GO:0032674)	3.93148427
44	germinal center formation (GO:0002467)	3.87796336
45	regulation of rhodopsin mediated signaling pathway (GO:0022400)	3.85947610
46	protein retention in ER lumen (GO:0006621)	3.84940931
47	response to mercury ion (GO:0046689)	3.75949857
48	somite rostral/caudal axis specification (GO:0032525)	3.74886617
49	regulation of nuclear cell cycle DNA replication (GO:0033262)	3.69089794
50	pantothenate metabolic process (GO:0015939)	3.67234446
51	heart valve formation (GO:0003188)	3.65784278
52	flavonoid metabolic process (GO:0009812)	3.63407242
53	alditol metabolic process (GO:0019400)	3.63070049
54	DNA damage induced protein phosphorylation (GO:0006975)	3.61580968
55	regulation of nephron tubule epithelial cell differentiation (GO:0072182)	3.61576189
56	cellular response to gamma radiation (GO:0071480)	3.59946823
57	toxin metabolic process (GO:0009404)	3.57867770
58	iron coordination entity transport (GO:1901678)	3.53838994
59	rhodopsin mediated signaling pathway (GO:0016056)	3.51788824
60	positive regulation of SMAD protein import into nucleus (GO:0060391)	3.49908324
61	sympathetic nervous system development (GO:0048485)	3.45806991
62	aromatic amino acid family catabolic process (GO:0009074)	3.43170410
63	response to epinephrine (GO:0071871)	3.41785006
64	sulfur compound transport (GO:0072348)	3.34452739
65	centriole assembly (GO:0098534)	3.33723524
66	regulation of developmental pigmentation (GO:0048070)	3.32736488
67	inflammatory response to antigenic stimulus (GO:0002437)	3.30178314
68	organ induction (GO:0001759)	3.26164227
69	maintenance of protein localization in endoplasmic reticulum (GO:0035437)	3.24004571
70	urate metabolic process (GO:0046415)	3.23834176
71	negative regulation of neural precursor cell proliferation (GO:2000178)	3.23590167
72	negative regulation of cell-matrix adhesion (GO:0001953)	3.17797175
73	regulation of epithelial cell differentiation involved in kidney development (GO:2000696)	3.14014154
74	regulation of keratinocyte proliferation (GO:0010837)	3.10905161
75	aspartate family amino acid catabolic process (GO:0009068)	3.07837527
76	embryonic process involved in female pregnancy (GO:0060136)	3.05190389
77	lysine catabolic process (GO:0006554)	3.01883318
78	lysine metabolic process (GO:0006553)	3.01883318
79	aromatic amino acid family metabolic process (GO:0009072)	2.92706553
80	polyol biosynthetic process (GO:0046173)	2.91599856
81	biotin metabolic process (GO:0006768)	2.90604818
82	membrane lipid biosynthetic process (GO:0046467)	2.87666157
83	sphingolipid biosynthetic process (GO:0030148)	2.87385869
84	uterus development (GO:0060065)	2.81448629
85	regulation of glucocorticoid secretion (GO:2000849)	2.79737309
86	protein kinase C-activating G-protein coupled receptor signaling pathway (GO:0007205)	2.79310449
87	mitochondrial fission (GO:0000266)	2.78464662
88	DNA methylation (GO:0006306)	2.75324550
89	DNA alkylation (GO:0006305)	2.75324550
90	regulation of hair follicle development (GO:0051797)	2.70919508
91	regulation of SMAD protein import into nucleus (GO:0060390)	2.67014020
92	positive regulation of action potential (GO:0045760)	2.62524839
93	2-oxoglutarate metabolic process (GO:0006103)	2.61230293
94	left/right axis specification (GO:0070986)	2.56739631
95	cofactor transport (GO:0051181)	2.54970866
96	embryonic skeletal joint morphogenesis (GO:0060272)	2.50006002
97	positive regulation of steroid hormone secretion (GO:2000833)	2.49376771
98	sphingosine metabolic process (GO:0006670)	16.4818334
99	diol metabolic process (GO:0034311)	14.8794118
100	sphingoid metabolic process (GO:0046519)	13.3498904

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	IGF1R_20145208_ChIP-Seq_DFB_Human	5.15907026
2	AR_21572438_ChIP-Seq_LNCaP_Human	4.86252176
3	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	3.19431899
4	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	3.12449349
5	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.92164368
6	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	2.86443692
7	GBX2_23144817_ChIP-Seq_PC3_Human	2.72653741
8	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.70632445
9	EZH2_22144423_ChIP-Seq_EOC_Human	2.52481850
10	P300_19829295_ChIP-Seq_ESCs_Human	2.38419982
11	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.33700255
12	ZNF274_21170338_ChIP-Seq_K562_Hela	2.19507509
13	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.12350891
14	ER_23166858_ChIP-Seq_MCF-7_Human	1.98921284
15	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.97154253
16	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.87807191
17	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.84976084
18	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.83775517
19	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.80657003
20	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.80657003
21	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.78268371
22	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.77479074
23	SOX2_19829295_ChIP-Seq_ESCs_Human	1.76405864
24	NANOG_19829295_ChIP-Seq_ESCs_Human	1.76405864
25	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.73497461
26	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.72697007
27	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.70983820
28	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.68045632
29	STAT3_23295773_ChIP-Seq_U87_Human	1.65659673
30	NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human	1.63081155
31	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.60282977
32	EGR1_19032775_ChIP-ChIP_M12_Human	1.59680835
33	TCF4_23295773_ChIP-Seq_U87_Human	1.59114928
34	VDR_22108803_ChIP-Seq_LS180_Human	1.58758050
35	HOXB7_26014856_ChIP-Seq_BT474_Human	1.57272583
36	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.50798485
37	STAT3_19079543_ChIP-ChIP_MESCs_Mouse	1.48547268
38	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.46648305
39	AR_25329375_ChIP-Seq_VCAP_Human	1.46397739
40	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.45413826
41	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.45023212
42	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.37711760
43	SMAD4_21799915_ChIP-Seq_A2780_Human	1.37253777
44	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.37061099
45	STAT3_18555785_ChIP-Seq_MESCs_Mouse	1.36275464
46	FUS_26573619_Chip-Seq_HEK293_Human	1.32565627
47	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.31939127
48	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.29015251
49	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.28352195
50	OCT4_20526341_ChIP-Seq_ESCs_Human	1.26207373
51	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.25476166
52	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.25317766
53	AR_19668381_ChIP-Seq_PC3_Human	1.24786493
54	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.24088096
55	SMAD3_21741376_ChIP-Seq_ESCs_Human	1.24018738
56	SMAD3_21741376_ChIP-Seq_HESCs_Human	1.23009340
57	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.22554938
58	GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse	1.22045810
59	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.22001800
60	STAT1_20625510_ChIP-Seq_HELA_Human	1.20924955
61	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.18840089
62	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.18045431
63	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.17581460
64	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.17233002
65	FOXH1_21741376_ChIP-Seq_ESCs_Human	1.16283501
66	TAF15_26573619_Chip-Seq_HEK293_Human	1.16075586
67	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.14950575
68	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.13934393
69	NCOR_22424771_ChIP-Seq_293T_Human	1.12638755
70	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	1.12470966
71	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.12364575
72	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.11997815
73	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.11090779
74	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.11006534
75	CBP_20019798_ChIP-Seq_JUKART_Human	1.11006534
76	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.10295975
77	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.10151654
78	TBX3_20139965_ChIP-Seq_ESCs_Mouse	1.09666935
79	TBX3_20139965_ChIP-Seq_MESCs_Mouse	1.09005836
80	SOX9_26525672_Chip-Seq_Limbbuds_Mouse	1.08450499
81	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.07896300
82	TCF4_22108803_ChIP-Seq_LS180_Human	1.07471627
83	CTNNB1_20460455_ChIP-Seq_HCT116_Human	1.07462871
84	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.07129664
85	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.07129664
86	TP53_18474530_ChIP-ChIP_U2OS_Human	1.06323911
87	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.04860432
88	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.03635275
89	SMAD4_21741376_ChIP-Seq_HESCs_Human	1.01197018
90	TAL1_26923725_Chip-Seq_HPCs_Mouse	0.99625404
91	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.98523070
92	VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human	0.98245971
93	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	0.98086918
94	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.97744315
95	STAT1_17558387_ChIP-Seq_HELA_Human	0.97108494
96	LUZP1_20508642_ChIP-Seq_ESCs_Mouse	0.96563657
97	EZH2_27304074_Chip-Seq_ESCs_Mouse	0.96498711
98	CEBPB_22108803_ChIP-Seq_LS180_Human	0.96394529
99	TP53_16413492_ChIP-PET_HCT116_Human	0.95938728
100	CBP_21632823_ChIP-Seq_H3396_Human	0.95701244

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002837_dystrophic_cardiac_calcinosis	9.25123291
2	MP0003136_yellow_coat_color	7.79200805
3	MP0005171_absent_coat_pigmentation	7.32332806
4	MP0002653_abnormal_ependyma_morphology	6.22074448
5	MP0003890_abnormal_embryonic-extraembry	4.64678208
6	MP0003045_fibrosis	4.31438917
7	MP0003646_muscle_fatigue	3.98660583
8	MP0003879_abnormal_hair_cell	3.70257251
9	MP0000569_abnormal_digit_pigmentation	2.98145944
10	MP0004381_abnormal_hair_follicle	2.74074753
11	MP0005670_abnormal_white_adipose	2.39910671
12	MP0004147_increased_porphyrin_level	2.25774718
13	MP0002138_abnormal_hepatobiliary_system	2.21052987
14	MP0005085_abnormal_gallbladder_physiolo	2.10921451
15	MP0000749_muscle_degeneration	2.02614149
16	MP0005075_abnormal_melanosome_morpholog	1.87868392
17	MP0002168_other_aberrant_phenotype	1.81815840
18	MP0003705_abnormal_hypodermis_morpholog	1.78891689
19	MP0002938_white_spotting	1.74564471
20	MP0003195_calcinosis	1.49714611
21	MP0010352_gastrointestinal_tract_polyps	1.42675292
22	MP0006054_spinal_hemorrhage	1.40895824
23	MP0002160_abnormal_reproductive_system	1.31714649
24	MP0002095_abnormal_skin_pigmentation	1.31527137
25	MP0005365_abnormal_bile_salt	1.27428257
26	MP0001984_abnormal_olfaction	1.22021556
27	MP0004233_abnormal_muscle_weight	1.21580135
28	MP0002075_abnormal_coat/hair_pigmentati	1.19460526
29	MP0010386_abnormal_urinary_bladder	1.12446600
30	MP0003137_abnormal_impulse_conducting	1.12093763
31	MP0005395_other_phenotype	1.03204294
32	MP0002735_abnormal_chemical_nociception	0.98762718
33	MP0001486_abnormal_startle_reflex	0.97853098
34	MP0002269_muscular_atrophy	0.95274190
35	MP0001501_abnormal_sleep_pattern	0.93802207
36	MP0000427_abnormal_hair_cycle	0.93680541
37	MP0005174_abnormal_tail_pigmentation	0.84558204
38	MP0005330_cardiomyopathy	0.82434105
39	MP0001186_pigmentation_phenotype	0.81673741
40	MP0002272_abnormal_nervous_system	0.79356200
41	MP0005410_abnormal_fertilization	0.71678254
42	MP0001324_abnormal_eye_pigmentation	0.70236171
43	MP0004043_abnormal_pH_regulation	0.69394118
44	MP0003252_abnormal_bile_duct	0.68601106
45	MP0005076_abnormal_cell_differentiation	0.67548737
46	MP0002254_reproductive_system_inflammat	0.67194044
47	MP0009745_abnormal_behavioral_response	0.65251502
48	MP0001970_abnormal_pain_threshold	0.65248864
49	MP0005377_hearing/vestibular/ear_phenot	0.64689363
50	MP0003878_abnormal_ear_physiology	0.64689363
51	MP0000534_abnormal_ureter_morphology	0.59665304
52	MP0005389_reproductive_system_phenotype	0.59471620
53	MP0003300_gastrointestinal_ulcer	0.58271030
54	MP0005319_abnormal_enzyme/_coenzyme	0.57433578
55	MP0008770_decreased_survivor_rate	0.57263451
56	MP0000015_abnormal_ear_pigmentation	0.57225265
57	MP0009046_muscle_twitch	0.56733906
58	MP0002971_abnormal_brown_adipose	0.55272847
59	MP0002064_seizures	0.54490019
60	MP0003937_abnormal_limbs/digits/tail_de	0.54375474
61	MP0008569_lethality_at_weaning	0.53719757
62	MP0002572_abnormal_emotion/affect_behav	0.52433029
63	MP0002751_abnormal_autonomic_nervous	0.51914331
64	MP0002928_abnormal_bile_duct	0.51588785
65	MP0005551_abnormal_eye_electrophysiolog	0.49597521
66	MP0008872_abnormal_physiological_respon	0.48202336
67	MP0002229_neurodegeneration	0.46507578
68	MP0004142_abnormal_muscle_tone	0.46323206
69	MP0002876_abnormal_thyroid_physiology	0.44898040
70	MP0002332_abnormal_exercise_endurance	0.44491285
71	MP0009115_abnormal_fat_cell	0.43828032
72	MP0000026_abnormal_inner_ear	0.42489090
73	MP0001963_abnormal_hearing_physiology	0.41903957
74	MP0001661_extended_life_span	0.40007748
75	MP0009764_decreased_sensitivity_to	0.39210812
76	MP0003632_abnormal_nervous_system	0.37983347
77	MP0006276_abnormal_autonomic_nervous	0.37002934
78	MP0003950_abnormal_plasma_membrane	0.36357677
79	MP0003635_abnormal_synaptic_transmissio	0.34759071
80	MP0004484_altered_response_of	0.34489771
81	MP0005220_abnormal_exocrine_pancreas	0.34069417
82	MP0001986_abnormal_taste_sensitivity	0.34021015
83	MP0000778_abnormal_nervous_system	0.32757062
84	MP0004130_abnormal_muscle_cell	0.31367191
85	MP0002733_abnormal_thermal_nociception	0.31267410
86	MP0006072_abnormal_retinal_apoptosis	0.29583238
87	MP0005646_abnormal_pituitary_gland	0.29516843
88	MP0003698_abnormal_male_reproductive	0.28864778
89	MP0003385_abnormal_body_wall	0.27658528
90	MP0002752_abnormal_somatic_nervous	0.27245439
91	MP0002106_abnormal_muscle_physiology	0.27169082
92	MP0000377_abnormal_hair_follicle	0.27141838
93	MP0001968_abnormal_touch/_nociception	0.27070279
94	MP0005253_abnormal_eye_physiology	0.26867273
95	MP0002396_abnormal_hematopoietic_system	0.24808121
96	MP0010307_abnormal_tumor_latency	0.24569799
97	MP0002882_abnormal_neuron_morphology	0.24330130
98	MP0005266_abnormal_metabolism	0.24269420
99	MP0003959_abnormal_lean_body	0.23736716
100	MP0002102_abnormal_ear_morphology	0.23410454

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Focal motor seizures (HP:0011153)	9.72499921
2	Amelogenesis imperfecta (HP:0000705)	9.68616889
3	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	7.32547291
4	Acanthocytosis (HP:0001927)	7.18493333
5	Parakeratosis (HP:0001036)	7.06207977
6	Aplastic anemia (HP:0001915)	5.67668358
7	Proximal amyotrophy (HP:0007126)	4.96316689
8	Rectal prolapse (HP:0002035)	4.82795146
9	Dialeptic seizures (HP:0011146)	4.80943866
10	Colon cancer (HP:0003003)	4.63129674
11	Hematochezia (HP:0002573)	4.23545562
12	Abnormality of aromatic amino acid family metabolism (HP:0004338)	4.08633319
13	Aplasia/Hypoplasia of the uvula (HP:0010293)	4.06598400
14	Vertebral arch anomaly (HP:0008438)	4.05685212
15	Congenital ichthyosiform erythroderma (HP:0007431)	4.02706594
16	Spontaneous hematomas (HP:0007420)	3.95052200
17	Focal seizures (HP:0007359)	3.95027461
18	Pancreatic cysts (HP:0001737)	3.85454318
19	Difficulty walking (HP:0002355)	3.76892527
20	Erythroderma (HP:0001019)	3.73552702
21	Scapular winging (HP:0003691)	3.56607410
22	Ulnar claw (HP:0001178)	3.43735451
23	Overlapping toe (HP:0001845)	3.22291494
24	Facial shape deformation (HP:0011334)	3.15601054
25	Potter facies (HP:0002009)	3.15601054
26	Conjunctival telangiectasia (HP:0000524)	3.14801275
27	Poikilocytosis (HP:0004447)	3.09405040
28	Bilateral sensorineural hearing impairment (HP:0008619)	3.05853698
29	Radial bowing (HP:0002986)	3.01356535
30	Pendular nystagmus (HP:0012043)	2.96762197
31	Esophageal varix (HP:0002040)	2.96239656
32	Ulnar bowing (HP:0003031)	2.93995666
33	Abnormality of the renal cortex (HP:0011035)	2.84017748
34	Abnormality of monocarboxylic acid metabolism (HP:0010996)	2.82591103
35	Abnormality of macular pigmentation (HP:0008002)	2.82392092
36	Cerebellar dysplasia (HP:0007033)	2.77539477
37	Enlarged kidneys (HP:0000105)	2.71829701
38	Broad ribs (HP:0000885)	2.71412107
39	Decreased number of large peripheral myelinated nerve fibers (HP:0003387)	2.69788096
40	Synostosis of carpal bones (HP:0005048)	2.66372216
41	Hypoplastic iliac wings (HP:0002866)	2.65429514
42	Progressive inability to walk (HP:0002505)	2.65332210
43	Abnormality of the renal medulla (HP:0100957)	2.62351761
44	Abnormality of the vasculature of the conjunctiva (HP:0008054)	2.46032556
45	IgM deficiency (HP:0002850)	2.44233457
46	Portal hypertension (HP:0001409)	2.43687373
47	Abnormality of the vocal cords (HP:0008777)	2.42857353
48	Nephronophthisis (HP:0000090)	2.42294301
49	Type II lissencephaly (HP:0007260)	2.35692643
50	Petechiae (HP:0000967)	2.33044490
51	Abnormality of the shoulder girdle musculature (HP:0001435)	2.30409348
52	Tarsal synostosis (HP:0008368)	2.20795782
53	Abnormality of the hepatic vasculature (HP:0006707)	2.20319132
54	Opisthotonus (HP:0002179)	2.19985987
55	Hypokalemia (HP:0002900)	2.19100591
56	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.13870959
57	Gangrene (HP:0100758)	2.13026686
58	Abnormal albumin level (HP:0012116)	2.11583807
59	Hypoalbuminemia (HP:0003073)	2.11583807
60	Peripheral hypomyelination (HP:0007182)	2.10916496
61	Tubular atrophy (HP:0000092)	2.09498029
62	Recurrent sinusitis (HP:0011108)	2.07807958
63	Inability to walk (HP:0002540)	2.07359165
64	Synostosis involving bones of the lower limbs (HP:0009138)	2.05890598
65	Synostosis involving bones of the feet (HP:0009140)	2.05890598
66	Cystic liver disease (HP:0006706)	2.03971064
67	Neoplasm of the small intestine (HP:0100833)	2.03185426
68	Chronic diarrhea (HP:0002028)	2.02462631
69	Type I transferrin isoform profile (HP:0003642)	2.01489338
70	Albinism (HP:0001022)	2.00400402
71	Dehydration (HP:0001944)	1.99787323
72	Thickened calvaria (HP:0002684)	1.99496789
73	Severe visual impairment (HP:0001141)	1.97061406
74	Tubulointerstitial fibrosis (HP:0005576)	1.96497653
75	Abnormality of the wing of the ilium (HP:0011867)	1.95815402
76	Decreased circulating renin level (HP:0003351)	1.95798362
77	Retinitis pigmentosa (HP:0000510)	1.94147321
78	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.92246975
79	Abnormality of potassium homeostasis (HP:0011042)	1.91804188
80	Lack of skin elasticity (HP:0100679)	1.90392842
81	Pancreatic fibrosis (HP:0100732)	1.87618371
82	Neoplasm of the colon (HP:0100273)	1.83477385
83	Visceral angiomatosis (HP:0100761)	1.81518767
84	Chromsome breakage (HP:0040012)	1.80654444
85	Bowed forearm bones (HP:0003956)	1.77898634
86	Bowing of the arm (HP:0006488)	1.77898634
87	Hemangiomatosis (HP:0007461)	1.77006830
88	Carpal synostosis (HP:0009702)	1.74590475
89	Autoimmune hemolytic anemia (HP:0001890)	1.73851128
90	Congenital hepatic fibrosis (HP:0002612)	1.73746355
91	Abnormality of the fingertips (HP:0001211)	1.70111074
92	Stomach cancer (HP:0012126)	1.68230814
93	Chronic hepatic failure (HP:0100626)	1.65646914
94	Atonic seizures (HP:0010819)	1.62562573
95	2-3 toe syndactyly (HP:0004691)	1.62203737
96	Intestinal polyp (HP:0005266)	1.60568923
97	Aortic valve stenosis (HP:0001650)	1.60556022
98	Posterior embryotoxon (HP:0000627)	1.58807963
99	Palmoplantar keratoderma (HP:0000982)	1.58370123
100	Pancytopenia (HP:0001876)	1.57162977

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	STK38L	7.31166225
2	LATS2	6.71607986
3	PRKD3	3.13384222
4	ZAK	2.89826367
5	STK38	2.74528867
6	ACVR1B	2.47737321
7	NLK	2.41626888
8	FRK	2.38009781
9	STK3	2.06569103
10	MAP2K2	2.03967717
11	LATS1	10.9242780
12	BMPR1B	1.93607999
13	MELK	1.90943072
14	MAP3K2	1.24838535
15	NEK2	1.09023541
16	KSR2	1.06445580
17	PRKAA2	0.97660998
18	PIK3CG	0.92022765
19	PDPK1	0.89856722
20	TGFBR1	0.89797959
21	CSNK1A1L	0.86797873
22	GRK7	0.81611639
23	PINK1	0.76490789
24	TAF1	0.70518682
25	IRAK3	0.67749536
26	PRKD1	0.61771352
27	EIF2AK3	0.60083197
28	NEK9	0.59495052
29	TGFBR2	0.51984522
30	DAPK2	0.51097534
31	MOS	0.50852996
32	INSRR	0.49202588
33	ADRBK1	0.47584476
34	ADRBK2	0.46648562
35	TTK	0.43889994
36	STK11	0.42364948
37	TNK2	0.35626047
38	NME1	0.33176513
39	MAP2K1	0.31592506
40	GRK5	0.31152849
41	PLK1	0.27720547
42	PIM1	0.24472989
43	FER	0.21575812
44	TAOK3	0.21496011
45	BCKDK	0.20931461
46	CSNK1D	0.20319731
47	NTRK3	0.19583165
48	STK10	0.19282371
49	WNK4	0.18070211
50	MAPK13	0.17494073
51	WNK3	0.17489760
52	PRKCE	0.17308381
53	PLK2	0.17267010
54	CHEK2	0.15861850
55	NEK1	0.13754712
56	AKT2	0.13064739
57	CDK3	0.12877267
58	ABL1	0.10935591
59	CAMK2B	0.10823670
60	NEK6	0.10433370
61	OXSR1	0.10039185
62	MAP3K4	0.09584036
63	PRKCI	0.09576615
64	PRKACA	0.09549031
65	CAMK2A	0.09522244
66	MAPK3	0.09206126
67	PLK4	0.08947985
68	MARK1	0.07962950
69	STK39	0.07617305
70	MAP3K7	0.06459882
71	RET	0.05627854
72	PRKACB	0.04648817
73	PTK2B	0.04370026
74	MAP3K1	0.03721854
75	MAPK1	0.03134072
76	CSNK1G2	0.02851606
77	JAK2	0.02746368
78	ATR	0.02067978
79	CDK5	0.01293436
80	MAP3K8	0.01286420
81	EPHA4	0.00875563
82	MAP2K7	0.00829426
83	CASK	0.00540474
84	PLK3	0.00339176
85	CSNK1A1	0.00073173
86	PRKCB	-0.0517084
87	AKT1	-0.0507638
88	MKNK1	-0.0498367
89	NUAK1	-0.0387756
90	MKNK2	-0.0313350
91	PRKCZ	-0.0312374
92	TRIM28	-0.0275454
93	MAPK8	-0.0274173
94	PRKCG	-0.0199825
95	GRK1	-0.0188753
96	ITK	-0.0170946
97	TXK	-0.0158159
98	EIF2AK2	-0.0144965
99	TEC	-0.0096177
100	CSNK1G3	-0.0076854

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	8.40910286
2	Phototransduction_Homo sapiens_hsa04744	4.46177654
3	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	4.19591576
4	Sphingolipid metabolism_Homo sapiens_hsa00600	3.94093483
5	Nicotine addiction_Homo sapiens_hsa05033	3.32590240
6	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	3.18390653
7	Dorso-ventral axis formation_Homo sapiens_hsa04320	2.64770974
8	Taste transduction_Homo sapiens_hsa04742	2.31302073
9	Phenylalanine metabolism_Homo sapiens_hsa00360	2.16275288
10	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	2.14595145
11	N-Glycan biosynthesis_Homo sapiens_hsa00510	1.94330970
12	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.77740861
13	Morphine addiction_Homo sapiens_hsa05032	1.73032230
14	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	1.68618574
15	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.68192580
16	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.52854039
17	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	1.48099900
18	Butanoate metabolism_Homo sapiens_hsa00650	1.46099256
19	GABAergic synapse_Homo sapiens_hsa04727	1.41085125
20	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.30517075
21	Tryptophan metabolism_Homo sapiens_hsa00380	1.23244825
22	Histidine metabolism_Homo sapiens_hsa00340	1.20710426
23	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.19749234
24	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.15852519
25	Calcium signaling pathway_Homo sapiens_hsa04020	1.11167652
26	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.03117214
27	Nitrogen metabolism_Homo sapiens_hsa00910	0.99167415
28	Viral myocarditis_Homo sapiens_hsa05416	0.96686936
29	One carbon pool by folate_Homo sapiens_hsa00670	0.96500170
30	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.93906179
31	Glutamatergic synapse_Homo sapiens_hsa04724	0.92782755
32	Tyrosine metabolism_Homo sapiens_hsa00350	0.92233527
33	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.88985588
34	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.87701657
35	ABC transporters_Homo sapiens_hsa02010	0.87678367
36	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.83320458
37	Basal transcription factors_Homo sapiens_hsa03022	0.82896218
38	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.74701549
39	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.74050088
40	Bile secretion_Homo sapiens_hsa04976	0.73955147
41	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.68226663
42	Serotonergic synapse_Homo sapiens_hsa04726	0.66538202
43	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.65949112
44	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.65735580
45	Homologous recombination_Homo sapiens_hsa03440	0.65312871
46	VEGF signaling pathway_Homo sapiens_hsa04370	0.64085071
47	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.62946754
48	Fanconi anemia pathway_Homo sapiens_hsa03460	0.60565527
49	Adherens junction_Homo sapiens_hsa04520	0.60139644
50	Hippo signaling pathway_Homo sapiens_hsa04390	0.58097849
51	cAMP signaling pathway_Homo sapiens_hsa04024	0.58096384
52	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.57511670
53	beta-Alanine metabolism_Homo sapiens_hsa00410	0.56122756
54	Glycerolipid metabolism_Homo sapiens_hsa00561	0.55605251
55	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.54319404
56	Colorectal cancer_Homo sapiens_hsa05210	0.54181125
57	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.52114722
58	Olfactory transduction_Homo sapiens_hsa04740	0.51439043
59	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.49946552
60	Fatty acid degradation_Homo sapiens_hsa00071	0.49937277
61	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.46456806
62	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.45681042
63	ECM-receptor interaction_Homo sapiens_hsa04512	0.45468589
64	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	0.45187600
65	Pyruvate metabolism_Homo sapiens_hsa00620	0.44482253
66	Lysine degradation_Homo sapiens_hsa00310	0.42673282
67	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.42669947
68	Basal cell carcinoma_Homo sapiens_hsa05217	0.41705392
69	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.41272469
70	Folate biosynthesis_Homo sapiens_hsa00790	0.40824333
71	Collecting duct acid secretion_Homo sapiens_hsa04966	0.38559299
72	Circadian entrainment_Homo sapiens_hsa04713	0.37967237
73	Thyroid cancer_Homo sapiens_hsa05216	0.37755080
74	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	0.33386561
75	Oocyte meiosis_Homo sapiens_hsa04114	0.30881133
76	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.30790740
77	Melanogenesis_Homo sapiens_hsa04916	0.28080923
78	Arginine and proline metabolism_Homo sapiens_hsa00330	0.28021255
79	Sulfur relay system_Homo sapiens_hsa04122	0.27861614
80	Cell cycle_Homo sapiens_hsa04110	0.27646914
81	Retinol metabolism_Homo sapiens_hsa00830	0.26340649
82	Salivary secretion_Homo sapiens_hsa04970	0.26169493
83	Propanoate metabolism_Homo sapiens_hsa00640	0.24100220
84	Chemical carcinogenesis_Homo sapiens_hsa05204	0.22765384
85	Insulin secretion_Homo sapiens_hsa04911	0.22531279
86	Gap junction_Homo sapiens_hsa04540	0.21327216
87	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.20707862
88	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.20612609
89	Metabolic pathways_Homo sapiens_hsa01100	0.19455670
90	Cholinergic synapse_Homo sapiens_hsa04725	0.18783202
91	Estrogen signaling pathway_Homo sapiens_hsa04915	0.17166810
92	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.17076504
93	Tuberculosis_Homo sapiens_hsa05152	0.14513411
94	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.14436438
95	Gastric acid secretion_Homo sapiens_hsa04971	0.14219228
96	Selenocompound metabolism_Homo sapiens_hsa00450	0.14107332
97	Linoleic acid metabolism_Homo sapiens_hsa00591	0.13353194
98	Type II diabetes mellitus_Homo sapiens_hsa04930	0.12526576
99	Peroxisome_Homo sapiens_hsa04146	0.12480517
100	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.12381168

PPP1R8P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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