PPP2CA

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes the phosphatase 2A catalytic subunit. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. This gene encodes an alpha isoform of the catalytic subunit. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1establishment of integrated proviral latency (GO:0075713)4.96987566
2synaptic vesicle maturation (GO:0016188)4.63832289
3layer formation in cerebral cortex (GO:0021819)4.53873218
4positive regulation of dendritic spine morphogenesis (GO:0061003)4.51613834
5regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)4.44653950
6establishment of viral latency (GO:0019043)4.34295380
7cell migration in hindbrain (GO:0021535)4.31889552
8proline biosynthetic process (GO:0006561)4.31709416
9locomotory exploration behavior (GO:0035641)4.26034488
10protein localization to endosome (GO:0036010)4.25954985
11regulation of respiratory gaseous exchange by neurological system process (GO:0002087)4.17396915
12Golgi transport vesicle coating (GO:0048200)4.13571212
13COPI coating of Golgi vesicle (GO:0048205)4.13571212
14embryonic process involved in female pregnancy (GO:0060136)4.08495927
15de novo posttranslational protein folding (GO:0051084)4.05048656
16regulation of short-term neuronal synaptic plasticity (GO:0048172)3.97923082
17de novo protein folding (GO:0006458)3.97470169
18establishment of apical/basal cell polarity (GO:0035089)3.93336599
19synaptic vesicle exocytosis (GO:0016079)3.90513876
20establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.89998840
21mitochondrion transport along microtubule (GO:0047497)3.89998840
22positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.84915959
23regulation of cAMP-dependent protein kinase activity (GO:2000479)3.81826887
24neuromuscular process controlling balance (GO:0050885)3.79491078
25positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.79236740
26establishment or maintenance of monopolar cell polarity (GO:0061339)3.71162395
27establishment of monopolar cell polarity (GO:0061162)3.71162395
28establishment of mitochondrion localization (GO:0051654)3.70793321
29protein deneddylation (GO:0000338)3.70560526
30dosage compensation (GO:0007549)3.61715467
31ribosome assembly (GO:0042255)3.55872383
32regulation of dendritic spine morphogenesis (GO:0061001)3.55466264
33peptidyl-arginine omega-N-methylation (GO:0035247)3.54557034
34dendritic spine morphogenesis (GO:0060997)3.54323611
35regulation of synaptic vesicle exocytosis (GO:2000300)3.54263788
36nuclear pore complex assembly (GO:0051292)3.51836726
37cullin deneddylation (GO:0010388)3.48963575
38DNA unwinding involved in DNA replication (GO:0006268)3.48854587
39positive regulation of mitochondrial fission (GO:0090141)3.47734624
40synaptic vesicle endocytosis (GO:0048488)3.46845492
41regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.41970508
42glutamate secretion (GO:0014047)3.39017494
43regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.38731843
44nuclear pore organization (GO:0006999)3.34627048
45regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway 3.34567779
46positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling3.34567779
47vocalization behavior (GO:0071625)3.33271248
48dendrite morphogenesis (GO:0048813)3.32732187
49peptidyl-arginine methylation (GO:0018216)3.31936229
50peptidyl-arginine N-methylation (GO:0035246)3.31936229
51positive regulation of dendritic spine development (GO:0060999)3.31561596
52L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.31328559
53pre-miRNA processing (GO:0031054)3.30920104
54neuron cell-cell adhesion (GO:0007158)3.29242777
55exploration behavior (GO:0035640)3.21601327
56regulation of respiratory system process (GO:0044065)3.17406150
57regulation of long-term neuronal synaptic plasticity (GO:0048169)3.15454989
58DNA damage response, detection of DNA damage (GO:0042769)3.15335333
59ribonucleoprotein complex disassembly (GO:0032988)3.14759654
60mitotic G1 DNA damage checkpoint (GO:0031571)3.14563841
61retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.14544186
62protein localization to synapse (GO:0035418)3.14324295
63G1 DNA damage checkpoint (GO:0044783)3.13488020
64deoxyribonucleotide biosynthetic process (GO:0009263)3.11888863
65regulation of neuronal synaptic plasticity (GO:0048168)3.10892828
66positive regulation of protein homooligomerization (GO:0032464)3.10522827
67signal complex assembly (GO:0007172)3.07769835
68regulation of glutamate receptor signaling pathway (GO:1900449)3.05730160
69regulation of translational termination (GO:0006449)3.04713400
70negative regulation of Ras GTPase activity (GO:0034261)3.03831763
71cytoskeletal anchoring at plasma membrane (GO:0007016)3.02378722
72protein complex localization (GO:0031503)3.01553544
73histone arginine methylation (GO:0034969)3.01545500
74regulation of early endosome to late endosome transport (GO:2000641)3.01494545
75regulation of ARF GTPase activity (GO:0032312)2.99552183
76protein localization to chromosome, centromeric region (GO:0071459)2.95747705
77positive regulation of dendrite morphogenesis (GO:0050775)2.92521883
78neuronal action potential propagation (GO:0019227)2.92311348
79organelle transport along microtubule (GO:0072384)2.91920777
80regulation of dendritic spine development (GO:0060998)2.91046552
81gamma-aminobutyric acid transport (GO:0015812)2.91005084
82neuron recognition (GO:0008038)2.90843423
83pore complex assembly (GO:0046931)2.90670168
84axonal fasciculation (GO:0007413)2.90016925
85positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.88145329
86mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.87992512
87anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.86189984
88regulation of protein homooligomerization (GO:0032462)2.86126944
89deoxyribose phosphate biosynthetic process (GO:0046385)2.85640770
902-deoxyribonucleotide biosynthetic process (GO:0009265)2.85640770
91central nervous system projection neuron axonogenesis (GO:0021952)2.85363142
92mitotic G1/S transition checkpoint (GO:0044819)2.84908505
93neuromuscular process (GO:0050905)2.84475819
94nerve growth factor signaling pathway (GO:0038180)2.83910299
95tRNA aminoacylation for protein translation (GO:0006418)2.83619282
96regulation of synaptic vesicle transport (GO:1902803)2.82626644
97ionotropic glutamate receptor signaling pathway (GO:0035235)2.82341153
98cellular response to ATP (GO:0071318)2.81561494
99DNA ligation (GO:0006266)2.81015232
100neurotransmitter secretion (GO:0007269)2.80750636
101protein targeting to vacuole (GO:0006623)2.80737847
102protein targeting to lysosome (GO:0006622)2.80737847
103establishment of protein localization to vacuole (GO:0072666)2.80737847
104neuromuscular process controlling posture (GO:0050884)2.80638150
105proline metabolic process (GO:0006560)2.79421207
106mitotic metaphase plate congression (GO:0007080)2.78682226
107regulation of synapse structural plasticity (GO:0051823)2.78518324
108RNA-dependent DNA replication (GO:0006278)2.77724287
109regulation of nucleobase-containing compound transport (GO:0032239)2.77625605
110positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.77548321
111negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.76544454
112amino acid activation (GO:0043038)2.76039064
113tRNA aminoacylation (GO:0043039)2.76039064
114asymmetric protein localization (GO:0008105)2.75978521
115cellular protein complex localization (GO:0034629)2.75945244
116regulation of translational fidelity (GO:0006450)2.75756351
117nucleobase-containing small molecule interconversion (GO:0015949)2.74712315
118transcription from mitochondrial promoter (GO:0006390)2.74685021
119proteasome assembly (GO:0043248)2.74315202
120regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.73074192
121regulation of clathrin-mediated endocytosis (GO:2000369)2.72787951
122positive regulation of receptor biosynthetic process (GO:0010870)2.72707020
123regulation of helicase activity (GO:0051095)2.72414010
124chaperone mediated protein folding requiring cofactor (GO:0051085)2.71841660
125hypotonic response (GO:0006971)2.70870943
126regulation of respiratory gaseous exchange (GO:0043576)2.67587751
127labyrinthine layer development (GO:0060711)2.66918666
128regulation of integrin activation (GO:0033623)2.65809243
129regulation of RNA export from nucleus (GO:0046831)2.65654372
130pyrimidine nucleobase catabolic process (GO:0006208)2.65494318
131negative regulation of microtubule polymerization (GO:0031115)2.65167554
132activation of protein kinase A activity (GO:0034199)2.64615310
133positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.63906604
134negative regulation of mRNA processing (GO:0050686)2.63639663
135amino acid import (GO:0043090)2.63094087
136regulation of translational elongation (GO:0006448)2.62881838
137organelle disassembly (GO:1903008)2.62212175
138sodium ion export (GO:0071436)2.60898854
139regulation of excitatory postsynaptic membrane potential (GO:0060079)2.60708648
140positive regulation of synapse maturation (GO:0090129)2.60222200
141respiratory system process (GO:0003016)2.59380143
142negative regulation of glial cell proliferation (GO:0060253)2.58778487
143negative regulation of protein oligomerization (GO:0032460)2.58067567
144cellular response to nerve growth factor stimulus (GO:1990090)2.57985303
145response to nerve growth factor (GO:1990089)2.57985303
146negative regulation of ligase activity (GO:0051352)2.57842327
147negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.57842327
148N-glycan processing (GO:0006491)2.57676597
149mating behavior (GO:0007617)2.57596963
150mitochondrial fission (GO:0000266)2.56299977
151establishment of nucleus localization (GO:0040023)2.55909219
152spliceosomal tri-snRNP complex assembly (GO:0000244)2.55526866
153formation of translation preinitiation complex (GO:0001731)2.55152375
154clathrin coat assembly (GO:0048268)2.54892624
155negative regulation of DNA recombination (GO:0045910)2.54558995
156vesicle transport along microtubule (GO:0047496)2.54130175
157positive regulation of dendrite development (GO:1900006)2.53923515
158G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.53642331
159negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.53340195
160localization within membrane (GO:0051668)2.53289914
161transmission of nerve impulse (GO:0019226)2.52621304
162synaptic vesicle docking involved in exocytosis (GO:0016081)2.51704628
163positive regulation of mitochondrion organization (GO:0010822)2.51418697
164glycolytic process (GO:0006096)2.51403765
165membrane tubulation (GO:0097320)2.51400738
166negative regulation of GTPase activity (GO:0034260)2.51096199
167maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.50996994
168mitochondrial fusion (GO:0008053)2.50400215
169cellular potassium ion homeostasis (GO:0030007)2.50220886
170protein insertion into membrane (GO:0051205)2.48738581
171L-serine metabolic process (GO:0006563)2.48735321
172protein localization to chromosome (GO:0034502)2.47605381
173protein localization to kinetochore (GO:0034501)2.47471636
174DNA strand elongation involved in DNA replication (GO:0006271)2.47412218
175mitotic sister chromatid segregation (GO:0000070)2.46908334
176positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.45949881
177negative regulation of synaptic transmission, GABAergic (GO:0032229)2.44973077
178membrane budding (GO:0006900)2.44928136
179termination of RNA polymerase II transcription (GO:0006369)2.43662072
180DNA strand elongation (GO:0022616)2.43599593
181pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.43217590
182substantia nigra development (GO:0021762)2.40202707

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.00642694
2MYC_18555785_ChIP-Seq_MESCs_Mouse3.80922892
3HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.67808269
4MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.64354776
5NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.57720132
6CREB1_15753290_ChIP-ChIP_HEK293T_Human3.49432364
7* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.45313507
8* NELFA_20434984_ChIP-Seq_ESCs_Mouse3.09975794
9EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse3.04565014
10ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.98891289
11EZH2_22144423_ChIP-Seq_EOC_Human2.96016113
12KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.94058016
13PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.89175509
14DCP1A_22483619_ChIP-Seq_HELA_Human2.78835730
15THAP11_20581084_ChIP-Seq_MESCs_Mouse2.78267293
16E2F4_17652178_ChIP-ChIP_JURKAT_Human2.65163684
17* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat2.64741107
18SALL4_18804426_ChIP-ChIP_MESCs_Mouse2.62967823
19ERG_21242973_ChIP-ChIP_JURKAT_Human2.61795133
20FOXM1_23109430_ChIP-Seq_U2OS_Human2.59382095
21JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.57559634
22* ZFX_18555785_ChIP-Seq_MESCs_Mouse2.55463259
23ETS1_20019798_ChIP-Seq_JURKAT_Human2.55375604
24ZFP281_18757296_ChIP-ChIP_E14_Mouse2.54546989
25MYC_19030024_ChIP-ChIP_MESCs_Mouse2.52879892
26SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.52141685
27XRN2_22483619_ChIP-Seq_HELA_Human2.51589703
28RARB_27405468_Chip-Seq_BRAIN_Mouse2.45004315
29MYC_18358816_ChIP-ChIP_MESCs_Mouse2.44871374
30MYC_19079543_ChIP-ChIP_MESCs_Mouse2.40750098
31FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.39555608
32TCF3_18467660_ChIP-ChIP_MESCs_Mouse2.39365866
33CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.37405766
34ZFP281_27345836_Chip-Seq_ESCs_Mouse2.35486101
35ZNF263_19887448_ChIP-Seq_K562_Human2.34150534
36KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.29622879
37KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.29622879
38KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.29622879
39* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.26518620
40MYCN_18555785_ChIP-Seq_MESCs_Mouse2.25653058
41GABP_17652178_ChIP-ChIP_JURKAT_Human2.15674472
42SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.15294287
43YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.15158560
44ZFP42_18358816_ChIP-ChIP_MESCs_Mouse2.14638056
45KDM2B_26808549_Chip-Seq_K562_Human2.14487512
46* GABP_19822575_ChIP-Seq_HepG2_Human2.14268217
47* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.12728974
48KDM2B_26808549_Chip-Seq_DND41_Human2.09940174
49KDM2B_26808549_Chip-Seq_SUP-B15_Human2.09847170
50CCND1_20090754_ChIP-ChIP_RETINA_Mouse2.07303101
51PRDM5_23873026_ChIP-Seq_MEFs_Mouse2.06792614
52* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.03237905
53POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.02689340
54AR_21572438_ChIP-Seq_LNCaP_Human2.01929190
55WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.00490605
56* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.98881149
57RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.97902473
58JARID2_20064375_ChIP-Seq_MESCs_Mouse1.96294527
59AR_21909140_ChIP-Seq_LNCAP_Human1.95660522
60PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.90086721
61RING1B_27294783_Chip-Seq_NPCs_Mouse1.87729606
62TTF2_22483619_ChIP-Seq_HELA_Human1.85061168
63EST1_17652178_ChIP-ChIP_JURKAT_Human1.84377500
64REST_21632747_ChIP-Seq_MESCs_Mouse1.82130590
65FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.81301423
66KDM2B_26808549_Chip-Seq_JURKAT_Human1.79331264
67* VDR_23849224_ChIP-Seq_CD4+_Human1.79277723
68SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.79191712
69* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.77353581
70LXR_22292898_ChIP-Seq_THP-1_Human1.77037810
71EZH2_18974828_ChIP-Seq_MESCs_Mouse1.73466623
72RNF2_18974828_ChIP-Seq_MESCs_Mouse1.73466623
73SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.72325096
74CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.71706217
75CIITA_25753668_ChIP-Seq_RAJI_Human1.69342050
76SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.68283048
77KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.66444535
78KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.66116404
79JARID2_20075857_ChIP-Seq_MESCs_Mouse1.66020655
80* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.65643153
81ELK1_19687146_ChIP-ChIP_HELA_Human1.64890439
82ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.64809629
83P300_27058665_Chip-Seq_ZR-75-30cells_Human1.62629301
84DROSHA_22980978_ChIP-Seq_HELA_Human1.61836069
85REST_18959480_ChIP-ChIP_MESCs_Mouse1.61475162
86EGR1_19374776_ChIP-ChIP_THP-1_Human1.60629184
87YY1_21170310_ChIP-Seq_MESCs_Mouse1.60038575
88IGF1R_20145208_ChIP-Seq_DFB_Human1.60020719
89CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.59635118
90RNF2_27304074_Chip-Seq_ESCs_Mouse1.59454839
91RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.59121087
92MTF2_20144788_ChIP-Seq_MESCs_Mouse1.57122544
93NANOG_18555785_ChIP-Seq_MESCs_Mouse1.53008501
94PADI4_21655091_ChIP-ChIP_MCF-7_Human1.53005254
95TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.52578689
96TRIM28_21343339_ChIP-Seq_HEK293_Human1.49854419
97CLOCK_20551151_ChIP-Seq_293T_Human1.49250830
98NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.48865069
99EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.48176818
100HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.48100660
101EZH2_27304074_Chip-Seq_ESCs_Mouse1.47926272
102FOXP3_21729870_ChIP-Seq_TREG_Human1.47862058
103SUZ12_27294783_Chip-Seq_ESCs_Mouse1.47313145
104* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.45242650
105VDR_21846776_ChIP-Seq_THP-1_Human1.44851591
106POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.43442625
107POU5F1_16518401_ChIP-PET_MESCs_Mouse1.42028878
108ZNF274_21170338_ChIP-Seq_K562_Hela1.41245730
109SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.40639521
110E2F1_21310950_ChIP-Seq_MCF-7_Human1.38688281
111RING1B_27294783_Chip-Seq_ESCs_Mouse1.38282230
112CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.37864546
113DNAJC2_21179169_ChIP-ChIP_NT2_Human1.36237568
114NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.35938298
115CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.35436609
116EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.35379004
117NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.35022259
118* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.34072266
119DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.33115833
120E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.32660690
121SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.31562093
122ESR1_15608294_ChIP-ChIP_MCF-7_Human1.30637967
123RACK7_27058665_Chip-Seq_MCF-7_Human1.30579939
124DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.29213540
125TCF3_18692474_ChIP-Seq_MESCs_Mouse1.27093233
126TP53_20018659_ChIP-ChIP_R1E_Mouse1.26611385
127ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.25871553
128TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.25089100
129* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.25017726
130MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.24917674
131NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.24555194
132REST_19997604_ChIP-ChIP_NEURONS_Mouse1.24324318
133SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.23333988
134ELF1_17652178_ChIP-ChIP_JURKAT_Human1.23077040
135POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.22787448
136WT1_19549856_ChIP-ChIP_CCG9911_Human1.22238252
137EZH2_27294783_Chip-Seq_ESCs_Mouse1.22037912
138HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.21169452
139MYC_22102868_ChIP-Seq_BL_Human1.20523189
140ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.20234995
141CREB1_26743006_Chip-Seq_LNCaP_Human1.20181424
142BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.19782000
143* CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.18818279
144SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.17886474
145KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.16211338
146ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.15055236
147GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.14838432
148SALL1_21062744_ChIP-ChIP_HESCs_Human1.14322801
149TFEB_21752829_ChIP-Seq_HELA_Human1.13347227
150SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.12428990
151HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.12360884
152* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.11939581
153RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.11148056
154* TCF7_22412390_ChIP-Seq_EML_Mouse1.11052510
155* KDM5A_27292631_Chip-Seq_BREAST_Human1.10627954
156IKZF1_21737484_ChIP-ChIP_HCT116_Human1.10534711
157PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.09205998
158MYC_18940864_ChIP-ChIP_HL60_Human1.08930285
159STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.07946416
160WT1_25993318_ChIP-Seq_PODOCYTE_Human1.07862326
161MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.06076794
162SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.04964221
163TET1_21490601_ChIP-Seq_MESCs_Mouse1.03726870
164SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.02814816
165ERG_20887958_ChIP-Seq_HPC-7_Mouse1.02628250
166FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.02199135
167POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.02139235
168CTCF_27219007_Chip-Seq_Bcells_Human1.00691212
169SOX17_20123909_ChIP-Seq_XEN_Mouse0.99742531
170TCF3_18692474_ChIP-Seq_MEFs_Mouse0.99570931
171SOX2_18555785_ChIP-Seq_MESCs_Mouse0.98511481
172* PKCTHETA_26484144_Chip-Seq_BREAST_Human0.97833396
173TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.97535666
174SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.94928385
175OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.93434103
176CTCF_27219007_Chip-Seq_ERYTHROID_Human0.93042321
177EED_16625203_ChIP-ChIP_MESCs_Mouse0.91994931
178* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.91811371
179ESR2_21235772_ChIP-Seq_MCF-7_Human0.90576094
180* EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.90571827
181NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.90110037
182FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.89942745
183NANOG_21062744_ChIP-ChIP_HESCs_Human0.89857522
184GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.88509109
185KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.87905691

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.14753414
2MP0001529_abnormal_vocalization3.26869358
3MP0003635_abnormal_synaptic_transmissio3.04830827
4MP0003880_abnormal_central_pattern3.02336643
5MP0005171_absent_coat_pigmentation2.86862477
6MP0004270_analgesia2.73136441
7MP0003693_abnormal_embryo_hatching2.64715279
8MP0004957_abnormal_blastocyst_morpholog2.62933551
9MP0008932_abnormal_embryonic_tissue2.58530230
10MP0003111_abnormal_nucleus_morphology2.57258870
11MP0010094_abnormal_chromosome_stability2.54207425
12MP0002063_abnormal_learning/memory/cond2.54144577
13MP0008058_abnormal_DNA_repair2.52296383
14MP0004233_abnormal_muscle_weight2.37348085
15MP0008057_abnormal_DNA_replication2.23814537
16MP0002064_seizures2.23339305
17MP0000778_abnormal_nervous_system2.18113366
18MP0003077_abnormal_cell_cycle2.16031179
19MP0001188_hyperpigmentation2.15763518
20MP0002877_abnormal_melanocyte_morpholog2.10232341
21MP0009046_muscle_twitch2.04527750
22MP0002822_catalepsy2.01698692
23MP0009278_abnormal_bone_marrow2.01419710
24MP0009745_abnormal_behavioral_response2.00845923
25MP0003283_abnormal_digestive_organ1.97020273
26MP0002572_abnormal_emotion/affect_behav1.91027824
27MP0005394_taste/olfaction_phenotype1.86672882
28MP0005499_abnormal_olfactory_system1.86672882
29MP0000955_abnormal_spinal_cord1.86320307
30MP0010234_abnormal_vibrissa_follicle1.85224802
31MP0008007_abnormal_cellular_replicative1.83441875
32MP0001727_abnormal_embryo_implantation1.81060602
33MP0004885_abnormal_endolymph1.78671113
34MP0000537_abnormal_urethra_morphology1.77270355
35MP0005423_abnormal_somatic_nervous1.75052935
36MP0002733_abnormal_thermal_nociception1.73746681
37MP0001730_embryonic_growth_arrest1.73176058
38MP0004811_abnormal_neuron_physiology1.69864007
39MP0006276_abnormal_autonomic_nervous1.68355359
40MP0005623_abnormal_meninges_morphology1.67852642
41MP0002009_preneoplasia1.67027436
42MP0003119_abnormal_digestive_system1.62983254
43MP0005076_abnormal_cell_differentiation1.61245220
44MP0005187_abnormal_penis_morphology1.56007744
45MP0001486_abnormal_startle_reflex1.54969236
46MP0006072_abnormal_retinal_apoptosis1.50543002
47MP0002272_abnormal_nervous_system1.49269006
48MP0001970_abnormal_pain_threshold1.48314931
49MP0003303_peritoneal_inflammation1.47436391
50MP0004185_abnormal_adipocyte_glucose1.46793756
51MP0008569_lethality_at_weaning1.45166181
52MP0006035_abnormal_mitochondrial_morpho1.44794081
53MP0008260_abnormal_autophagy1.44028128
54MP0000350_abnormal_cell_proliferation1.43585310
55MP0001177_atelectasis1.43512545
56MP0004147_increased_porphyrin_level1.42642540
57MP0002184_abnormal_innervation1.41927105
58MP0008789_abnormal_olfactory_epithelium1.41375109
59MP0003329_amyloid_beta_deposits1.40792066
60MP0005501_abnormal_skin_physiology1.39623639
61MP0010030_abnormal_orbit_morphology1.39420343
62MP0002734_abnormal_mechanical_nocicepti1.36984099
63MP0001984_abnormal_olfaction1.36810750
64MP0004142_abnormal_muscle_tone1.34408073
65MP0004924_abnormal_behavior1.33832610
66MP0005386_behavior/neurological_phenoty1.33832610
67MP0009697_abnormal_copulation1.32750047
68MP0002909_abnormal_adrenal_gland1.32535763
69MP0004782_abnormal_surfactant_physiolog1.31562007
70MP0003890_abnormal_embryonic-extraembry1.30773019
71MP0002882_abnormal_neuron_morphology1.30511861
72MP0001968_abnormal_touch/_nociception1.29603000
73MP0001440_abnormal_grooming_behavior1.29349916
74MP0000462_abnormal_digestive_system1.28873923
75MP0001348_abnormal_lacrimal_gland1.28539119
76MP0002067_abnormal_sensory_capabilities1.27808329
77MP0002152_abnormal_brain_morphology1.27779370
78MP0002066_abnormal_motor_capabilities/c1.26788835
79MP0000751_myopathy1.23168034
80MP0003634_abnormal_glial_cell1.22070832
81MP0009672_abnormal_birth_weight1.16591154
82MP0003861_abnormal_nervous_system1.16243426
83MP0003633_abnormal_nervous_system1.12743107
84MP0005380_embryogenesis_phenotype1.11441236
85MP0001672_abnormal_embryogenesis/_devel1.11441236
86* MP0002080_prenatal_lethality1.10624790
87MP0003315_abnormal_perineum_morphology1.10455387
88MP0005174_abnormal_tail_pigmentation1.10037818
89MP0002735_abnormal_chemical_nociception1.09863805
90MP0004133_heterotaxia1.09105887
91MP0002282_abnormal_trachea_morphology1.09085867
92MP0002332_abnormal_exercise_endurance1.06893813
93MP0004130_abnormal_muscle_cell1.06180569
94MP0004197_abnormal_fetal_growth/weight/1.06064859
95* MP0002084_abnormal_developmental_patter1.05651455
96MP0003385_abnormal_body_wall1.04502516
97MP0005367_renal/urinary_system_phenotyp1.03672454
98MP0000516_abnormal_urinary_system1.03672454
99MP0002249_abnormal_larynx_morphology1.03359727
100MP0003172_abnormal_lysosome_physiology1.02289721
101MP0000920_abnormal_myelination1.01801527
102MP0000647_abnormal_sebaceous_gland0.99770916
103MP0002557_abnormal_social/conspecific_i0.98741223
104MP0004858_abnormal_nervous_system0.96755984
105MP0003786_premature_aging0.96031883
106MP0002751_abnormal_autonomic_nervous0.94488485
107MP0000358_abnormal_cell_content/0.94385819
108MP0010352_gastrointestinal_tract_polyps0.93980119
109MP0009780_abnormal_chondrocyte_physiolo0.93786351
110MP0002736_abnormal_nociception_after0.92210149
111MP0000579_abnormal_nail_morphology0.91746841
112MP0003567_abnormal_fetal_cardiomyocyte0.91456086
113MP0003137_abnormal_impulse_conducting0.91446452
114MP0000747_muscle_weakness0.91410042
115MP0003631_nervous_system_phenotype0.90327723
116MP0001346_abnormal_lacrimal_gland0.90323068
117MP0004145_abnormal_muscle_electrophysio0.89634825
118* MP0001697_abnormal_embryo_size0.89587010
119MP0000467_abnormal_esophagus_morphology0.89400163
120MP0001340_abnormal_eyelid_morphology0.87144987
121MP0005645_abnormal_hypothalamus_physiol0.86901662
122MP0003984_embryonic_growth_retardation0.86667704
123MP0001943_abnormal_respiration0.86441285
124MP0003453_abnormal_keratinocyte_physiol0.85641983
125MP0000313_abnormal_cell_death0.85072913
126MP0005384_cellular_phenotype0.83999002
127MP0008770_decreased_survivor_rate0.83951364
128MP0003221_abnormal_cardiomyocyte_apopto0.83175755
129MP0005451_abnormal_body_composition0.82430728
130MP0002796_impaired_skin_barrier0.81854121
131MP0002088_abnormal_embryonic_growth/wei0.81385646
132MP0002081_perinatal_lethality0.80067063
133MP0001501_abnormal_sleep_pattern0.79771755
134MP0010769_abnormal_survival0.78190038
135MP0008877_abnormal_DNA_methylation0.78095000
136MP0000762_abnormal_tongue_morphology0.77564320
137MP0002234_abnormal_pharynx_morphology0.77349509
138* MP0002085_abnormal_embryonic_tissue0.77091423
139MP0002086_abnormal_extraembryonic_tissu0.76899713
140MP0010768_mortality/aging0.76505973
141MP0003755_abnormal_palate_morphology0.76286995
142MP0001502_abnormal_circadian_rhythm0.76281576
143MP0005621_abnormal_cell_physiology0.76010120
144MP0002114_abnormal_axial_skeleton0.75754390
145MP0003656_abnormal_erythrocyte_physiolo0.74820191
146MP0005248_abnormal_Harderian_gland0.73544397
147MP0002269_muscular_atrophy0.73518090
148MP0003935_abnormal_craniofacial_develop0.73147331
149MP0003122_maternal_imprinting0.72734011
150MP0000015_abnormal_ear_pigmentation0.71743429
151MP0002082_postnatal_lethality0.70710241
152MP0010770_preweaning_lethality0.70710241
153MP0003718_maternal_effect0.70045352
154MP0003632_abnormal_nervous_system0.68692931

Predicted human phenotypes

RankGene SetZ-score
1Cortical dysplasia (HP:0002539)5.07231755
2Annular pancreas (HP:0001734)4.48788037
3Myokymia (HP:0002411)4.09795023
4Shoulder girdle muscle weakness (HP:0003547)4.03558166
5Pelvic girdle muscle weakness (HP:0003749)3.58265966
6Abnormality of the hip-girdle musculature (HP:0001445)3.57227683
7Abnormality of the musculature of the pelvis (HP:0001469)3.57227683
8Cerebral hypomyelination (HP:0006808)3.54022792
9Visual hallucinations (HP:0002367)3.52941864
10Turricephaly (HP:0000262)3.37726113
11Abnormality of glycolysis (HP:0004366)3.31664618
12Concave nail (HP:0001598)3.22681757
13Increased serum pyruvate (HP:0003542)3.19106363
14Coronal craniosynostosis (HP:0004440)3.16693045
15Focal motor seizures (HP:0011153)3.15419498
16Decreased number of large peripheral myelinated nerve fibers (HP:0003387)3.14075409
17Facial hemangioma (HP:0000329)3.03551250
18Atrophy/Degeneration involving motor neurons (HP:0007373)3.02312252
19Atonic seizures (HP:0010819)3.01357186
20Spastic diplegia (HP:0001264)2.96408587
21Medulloblastoma (HP:0002885)2.96223533
22Action tremor (HP:0002345)2.94038172
23Termporal pattern (HP:0011008)2.92225324
24Insidious onset (HP:0003587)2.92225324
25Focal seizures (HP:0007359)2.89360135
26Degeneration of anterior horn cells (HP:0002398)2.88912717
27Abnormality of the anterior horn cell (HP:0006802)2.88912717
28Split foot (HP:0001839)2.84415196
29Upper limb muscle weakness (HP:0003484)2.78792813
30Obstructive sleep apnea (HP:0002870)2.78225256
31Postnatal microcephaly (HP:0005484)2.77105030
32Alacrima (HP:0000522)2.71265019
33Rib fusion (HP:0000902)2.69213130
34Retinal dysplasia (HP:0007973)2.63454739
35Microvesicular hepatic steatosis (HP:0001414)2.61556795
36Dysdiadochokinesis (HP:0002075)2.60085934
37Anteriorly placed anus (HP:0001545)2.59797644
38Intention tremor (HP:0002080)2.57869230
39Short chin (HP:0000331)2.56474346
40CNS hypomyelination (HP:0003429)2.56425660
41Ragged-red muscle fibers (HP:0003200)2.55097110
42Lower limb muscle weakness (HP:0007340)2.51304783
43Hypercortisolism (HP:0001578)2.50866166
44Hammertoe (HP:0001765)2.50219290
45Ulnar bowing (HP:0003031)2.48254927
46Epileptic encephalopathy (HP:0200134)2.42853114
47Akinesia (HP:0002304)2.42392126
48Sensorimotor neuropathy (HP:0007141)2.39272147
49Abnormality of the motor neurons (HP:0002450)2.38923697
50Abnormal neuron morphology (HP:0012757)2.38923697
51Abnormality of the lower motor neuron (HP:0002366)2.38526759
52Achilles tendon contracture (HP:0001771)2.37808080
53Supranuclear gaze palsy (HP:0000605)2.37446840
54Absence seizures (HP:0002121)2.37005986
55Limb-girdle muscle atrophy (HP:0003797)2.36211118
56Megalencephaly (HP:0001355)2.35333522
57Aqueductal stenosis (HP:0002410)2.35303078
58Papilledema (HP:0001085)2.33388605
59Cerebral inclusion bodies (HP:0100314)2.33075456
60Rimmed vacuoles (HP:0003805)2.31564851
61Exercise-induced muscle cramps (HP:0003710)2.30509661
62Fetal akinesia sequence (HP:0001989)2.30310841
63Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.30050953
64Decreased activity of mitochondrial respiratory chain (HP:0008972)2.30050953
65Delusions (HP:0000746)2.29920145
66Diminished motivation (HP:0000745)2.28483175
67Autoamputation (HP:0001218)2.27529240
68Clumsiness (HP:0002312)2.27521761
69Failure to thrive in infancy (HP:0001531)2.26500648
70Dysmetria (HP:0001310)2.26123527
71Mutism (HP:0002300)2.20680655
72Volvulus (HP:0002580)2.20413767
73Ankyloglossia (HP:0010296)2.18530118
74Deviation of the thumb (HP:0009603)2.17916321
75Macroorchidism (HP:0000053)2.16632183
76Cerebral aneurysm (HP:0004944)2.12697011
77Congenital hip dislocation (HP:0001374)2.10158867
78Hamartoma (HP:0010566)2.09798949
79Broad-based gait (HP:0002136)2.08973837
80Urinary urgency (HP:0000012)2.08160667
81Neuronal loss in central nervous system (HP:0002529)2.05512786
82Orthostatic hypotension (HP:0001278)2.04361015
83Decreased lacrimation (HP:0000633)2.02406257
84Amyotrophic lateral sclerosis (HP:0007354)2.02122060
85Selective tooth agenesis (HP:0001592)2.01833730
86Progressive cerebellar ataxia (HP:0002073)2.01011899
87Multiple enchondromatosis (HP:0005701)2.00843289
88Abnormality of the Achilles tendon (HP:0005109)2.00488052
89Proximal placement of thumb (HP:0009623)2.00380722
90Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.99720390
91Vertebral hypoplasia (HP:0008417)1.99720390
92Abnormality of the astrocytes (HP:0100707)1.99294460
93Astrocytoma (HP:0009592)1.99294460
94Dialeptic seizures (HP:0011146)1.98816089
95Poor eye contact (HP:0000817)1.97582823
96Ankle clonus (HP:0011448)1.96544387
97Thickened helices (HP:0000391)1.96234543
98Pointed chin (HP:0000307)1.95487036
99Tetraplegia (HP:0002445)1.95025654
100Febrile seizures (HP:0002373)1.93917143
101Distal sensory impairment (HP:0002936)1.92056338
102Hand muscle atrophy (HP:0009130)1.91852547
103Papillary thyroid carcinoma (HP:0002895)1.90962033
104Depression (HP:0000716)1.90792835
105Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.90340509
106Degeneration of the lateral corticospinal tracts (HP:0002314)1.90340509
107Cholecystitis (HP:0001082)1.90206848
108Abnormal gallbladder physiology (HP:0012438)1.90206848
109Impaired social interactions (HP:0000735)1.89873560
110Abnormal social behavior (HP:0012433)1.89873560
111Rectal fistula (HP:0100590)1.89256371
112Rectovaginal fistula (HP:0000143)1.89256371
113Insomnia (HP:0100785)1.89159831
114Clonus (HP:0002169)1.89056798
115Basal cell carcinoma (HP:0002671)1.88905310
116Limb-girdle muscle weakness (HP:0003325)1.88675140
117Unsteady gait (HP:0002317)1.87202843
118Unilateral renal agenesis (HP:0000122)1.86886770
119Abnormality of the corticospinal tract (HP:0002492)1.85772428
120Short humerus (HP:0005792)1.84883808
121Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.84715214
122Neurofibrillary tangles (HP:0002185)1.84347784
123Choanal stenosis (HP:0000452)1.83992899
124Male infertility (HP:0003251)1.83906958
125Abnormality of the labia minora (HP:0012880)1.83387417
126Increased nuchal translucency (HP:0010880)1.80744588
127Peripheral hypomyelination (HP:0007182)1.80360727
128Urinary bladder sphincter dysfunction (HP:0002839)1.80282929
129Spastic paraplegia (HP:0001258)1.78901552
130Neoplasm of the peripheral nervous system (HP:0100007)1.78604658
131Hyperacusis (HP:0010780)1.78240894
132Limb dystonia (HP:0002451)1.78060680
133Genu recurvatum (HP:0002816)1.77383235
134Neuroblastic tumors (HP:0004376)1.75914976
135Peripheral primitive neuroectodermal neoplasm (HP:0030067)1.75914976
136Neuroblastoma (HP:0003006)1.75914976
137Primitive neuroectodermal tumor (HP:0030065)1.75914976
138Impaired vibration sensation in the lower limbs (HP:0002166)1.75393800
139Genetic anticipation (HP:0003743)1.75303361
140Broad alveolar ridges (HP:0000187)1.74067239
141Emotional lability (HP:0000712)1.73239123
142Bowel incontinence (HP:0002607)1.72877752
143Hypoplasia of the brainstem (HP:0002365)1.72837584
144Aplasia/Hypoplasia of the brainstem (HP:0007362)1.72837584
145Drooling (HP:0002307)1.72373046
146Excessive salivation (HP:0003781)1.72373046
147Lower limb amyotrophy (HP:0007210)1.72073702
148Congenital glaucoma (HP:0001087)1.71422019
149Rapidly progressive (HP:0003678)1.70894282
150Muscular hypotonia of the trunk (HP:0008936)1.70800914
151Inappropriate behavior (HP:0000719)1.70145195
152Narrow nasal bridge (HP:0000446)1.70016469
153Progressive external ophthalmoplegia (HP:0000590)1.69148992
154Glossoptosis (HP:0000162)1.68692024
155Scanning speech (HP:0002168)1.67947313
156Apathy (HP:0000741)1.67889545
157Abnormality of the foot musculature (HP:0001436)1.67854931
158Paraplegia (HP:0010550)1.67339809
159Bronchomalacia (HP:0002780)1.67309982
160Hypokinesia (HP:0002375)1.66822754
161Colon cancer (HP:0003003)1.65771863
162Diminished movement (HP:0002374)1.63944820
163Overriding aorta (HP:0002623)1.63863162
164Relative macrocephaly (HP:0004482)1.63434138
165Split hand (HP:0001171)1.62862576
166Fibular aplasia (HP:0002990)1.62699974
167Abnormality of the aortic arch (HP:0012303)1.62648954
168Alopecia of scalp (HP:0002293)1.61945186
169Arnold-Chiari malformation (HP:0002308)1.61925517
170Aplasia/hypoplasia of the humerus (HP:0006507)1.61623596
171Spastic gait (HP:0002064)1.61579556
172Fasciculations (HP:0002380)1.60027047
173Distal lower limb amyotrophy (HP:0008944)1.59626843

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ICK4.13092019
2SRPK13.70903141
3DDR23.54470382
4BCR3.29853675
5MAP3K93.27279050
6MAP3K63.24943902
7TYRO33.22276606
8MARK12.89476269
9TESK22.81626356
10FGR2.67553776
11UHMK12.60578853
12BUB12.60526639
13TESK12.55490063
14TRIM282.47758233
15TSSK62.19102402
16MAPK152.17596567
17CCNB11.98094933
18PINK11.96850657
19NTRK31.94754054
20MAP3K111.93765165
21PDGFRA1.92641872
22ARAF1.90590984
23DAPK11.85977048
24TRIB31.83097753
25MINK11.81010550
26BMX1.78683383
27PAK61.76422620
28MAP3K41.69039950
29PRKD21.68527576
30BCKDK1.68228477
31RPS6KA41.66391063
32SIK31.65354911
33PHKG21.64738541
34PHKG11.64738541
35LATS21.62868699
36ALK1.59968909
37KSR21.58817021
38RIPK11.57231519
39EPHA41.55262411
40SCYL21.48884327
41CDC71.47037677
42MATK1.41125469
43DYRK1B1.36571821
44NTRK11.34489379
45CSK1.28482939
46TTK1.25225440
47NTRK21.23934441
48KSR11.16968104
49PIM21.15085364
50CDK191.14943977
51EIF2AK11.14846981
52CDK51.06951916
53MAP4K21.06346858
54STK111.04481519
55STK161.02292661
56DAPK21.01782717
57CAMKK11.00714471
58CDK60.99745243
59MAP3K50.98837237
60CDK140.98113959
61FES0.95788949
62CASK0.93458711
63BRSK10.93022974
64DYRK30.92906595
65SIK20.92807549
66DMPK0.91663872
67STK380.90448454
68MAP2K40.90440281
69PRPF4B0.89795513
70CDK150.89612024
71TAOK10.89392214
72PLK10.89094677
73PNCK0.88792530
74PRKD30.87968327
75MAP3K120.84879577
76AURKA0.84871106
77BRD40.84248191
78WEE10.84187691
79HIPK20.83444805
80PBK0.82038757
81CDK180.81952072
82CDK11A0.81453940
83CSNK1G20.81195723
84GSK3A0.79774014
85CAMK2B0.79076511
86RET0.77653996
87MAP3K20.75587142
88PLK30.75524178
89IRAK20.75501468
90YES10.75441152
91PKN20.75002763
92RAF10.73340144
93CDC42BPA0.70636929
94PDGFRB0.70631003
95BRAF0.70352330
96EPHA30.70263644
97TNIK0.67900014
98PAK40.66471313
99CSNK1G10.66183044
100BMPR20.65393924
101ERBB30.63805672
102ERBB40.63478735
103EIF2AK30.63341082
104CAMK2A0.62367694
105ATR0.61979267
106AURKB0.60837902
107PLK20.60347332
108MAPK100.58011826
109DYRK1A0.57279898
110CSNK1G30.55745468
111CDK80.55490218
112LIMK10.55341052
113MKNK10.54835336
114MARK20.53716579
115SGK10.52951952
116DYRK20.52849317
117EPHA20.52812045
118CSNK1A1L0.52430181
119FER0.51349302
120MAP3K100.51134972
121LATS10.50878124
122CDK90.50016721
123FGFR20.46153581
124NME20.45389619
125KDR0.44739186
126CAMK2D0.44412924
127RPS6KC10.42214323
128RPS6KL10.42214323
129MAP2K70.41263500
130PRKAA10.41103460
131STK390.40888059
132RPS6KA10.40421377
133MAPK130.39954987
134TAOK20.39269848
135RPS6KA30.39026952
136CHEK20.39001951
137CHEK10.38526488
138CAMK2G0.38085229
139CSNK1E0.37149393
140VRK10.36615217
141PRKCZ0.36172206
142OXSR10.35632229
143PRKD10.35520010
144FGFR10.35407092
145PLK40.35211031
146PAK30.34900676
147FYN0.34867481
148CDK20.34665434
149MOS0.33499478
150CDK10.32736496
151NEK10.32725727
152PRKCH0.32518189
153MTOR0.32432589
154AKT20.32283796
155NEK60.32149511
156PTK20.29517948
157PAK20.28647660
158RIPK40.27848939

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.19218733
2Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009703.09281422
3Spliceosome_Homo sapiens_hsa030402.72005910
4Proteasome_Homo sapiens_hsa030502.71535849
5DNA replication_Homo sapiens_hsa030302.66505563
6Fatty acid biosynthesis_Homo sapiens_hsa000612.44656015
7Base excision repair_Homo sapiens_hsa034102.36722764
8Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.20275538
9Pathogenic Escherichia coli infection_Homo sapiens_hsa051302.17446240
10Biosynthesis of amino acids_Homo sapiens_hsa012302.13263599
112-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.12340500
12Long-term potentiation_Homo sapiens_hsa047202.10872299
13RNA transport_Homo sapiens_hsa030131.99723328
14Nicotine addiction_Homo sapiens_hsa050331.89617321
15Cell cycle_Homo sapiens_hsa041101.88549414
16Mismatch repair_Homo sapiens_hsa034301.88338947
17Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.86186539
18GABAergic synapse_Homo sapiens_hsa047271.85409090
19Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.81300258
20Gap junction_Homo sapiens_hsa045401.78787005
21Vibrio cholerae infection_Homo sapiens_hsa051101.76850188
22mTOR signaling pathway_Homo sapiens_hsa041501.74377645
23Non-homologous end-joining_Homo sapiens_hsa034501.71771651
24Glutamatergic synapse_Homo sapiens_hsa047241.70750907
25Olfactory transduction_Homo sapiens_hsa047401.69820792
26Synaptic vesicle cycle_Homo sapiens_hsa047211.69816318
27Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.69683324
28Amphetamine addiction_Homo sapiens_hsa050311.67838918
29* Dopaminergic synapse_Homo sapiens_hsa047281.64240631
30Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.63765694
31Circadian entrainment_Homo sapiens_hsa047131.61811171
32ErbB signaling pathway_Homo sapiens_hsa040121.58492764
33VEGF signaling pathway_Homo sapiens_hsa043701.55062021
34GnRH signaling pathway_Homo sapiens_hsa049121.53989973
35Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.53915777
36Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.52249806
37Morphine addiction_Homo sapiens_hsa050321.51337049
38Dorso-ventral axis formation_Homo sapiens_hsa043201.49465614
39Carbon metabolism_Homo sapiens_hsa012001.49361640
40* Long-term depression_Homo sapiens_hsa047301.49178634
41Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.46593737
42Estrogen signaling pathway_Homo sapiens_hsa049151.45886254
43Glioma_Homo sapiens_hsa052141.45525931
44Steroid biosynthesis_Homo sapiens_hsa001001.44553303
45Gastric acid secretion_Homo sapiens_hsa049711.44540574
46Salivary secretion_Homo sapiens_hsa049701.42064277
47Axon guidance_Homo sapiens_hsa043601.40551965
48* Hippo signaling pathway_Homo sapiens_hsa043901.39110613
49Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.38884858
50Cholinergic synapse_Homo sapiens_hsa047251.38077681
51Wnt signaling pathway_Homo sapiens_hsa043101.36596432
52Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.36528986
53Oxytocin signaling pathway_Homo sapiens_hsa049211.34967547
54Cysteine and methionine metabolism_Homo sapiens_hsa002701.30412769
55* Oocyte meiosis_Homo sapiens_hsa041141.29896846
56* Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.29827043
57Colorectal cancer_Homo sapiens_hsa052101.29714571
58Hedgehog signaling pathway_Homo sapiens_hsa043401.28897487
59Nucleotide excision repair_Homo sapiens_hsa034201.28772110
60Pyrimidine metabolism_Homo sapiens_hsa002401.26628864
61Aldosterone synthesis and secretion_Homo sapiens_hsa049251.25900631
62Melanogenesis_Homo sapiens_hsa049161.24796353
63Choline metabolism in cancer_Homo sapiens_hsa052311.21703244
64Renin secretion_Homo sapiens_hsa049241.19545110
65Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.14460841
66Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.13692424
67Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.11856093
68Endometrial cancer_Homo sapiens_hsa052131.09814498
69Renal cell carcinoma_Homo sapiens_hsa052111.09692689
70Longevity regulating pathway - mammal_Homo sapiens_hsa042111.08838508
71Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.08109068
72Fatty acid elongation_Homo sapiens_hsa000621.06989270
73Protein export_Homo sapiens_hsa030601.06562378
74Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.04307754
75Adherens junction_Homo sapiens_hsa045201.03773436
76Salmonella infection_Homo sapiens_hsa051321.03337393
77Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.02866794
78Chronic myeloid leukemia_Homo sapiens_hsa052201.02095770
79Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.01366686
80Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.01201665
81Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.00156148
82Nitrogen metabolism_Homo sapiens_hsa009100.99920897
83MAPK signaling pathway_Homo sapiens_hsa040100.99340365
84RNA polymerase_Homo sapiens_hsa030200.98411892
85Insulin secretion_Homo sapiens_hsa049110.96997985
86Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.96840087
87Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.96628451
88Endocytosis_Homo sapiens_hsa041440.96277620
89Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.95741637
90* Tight junction_Homo sapiens_hsa045300.95734699
91Cocaine addiction_Homo sapiens_hsa050300.95554734
92Neurotrophin signaling pathway_Homo sapiens_hsa047220.94251440
93Bladder cancer_Homo sapiens_hsa052190.93783092
94Phospholipase D signaling pathway_Homo sapiens_hsa040720.93626852
95Regulation of actin cytoskeleton_Homo sapiens_hsa048100.92729527
96Phosphatidylinositol signaling system_Homo sapiens_hsa040700.91301001
97Serotonergic synapse_Homo sapiens_hsa047260.90275033
98cAMP signaling pathway_Homo sapiens_hsa040240.87511443
99* Sphingolipid signaling pathway_Homo sapiens_hsa040710.87360205
100Circadian rhythm_Homo sapiens_hsa047100.86484226
101Basal cell carcinoma_Homo sapiens_hsa052170.86144221
102Collecting duct acid secretion_Homo sapiens_hsa049660.84491421
103Pentose phosphate pathway_Homo sapiens_hsa000300.83881299
104RNA degradation_Homo sapiens_hsa030180.83799011
105Non-small cell lung cancer_Homo sapiens_hsa052230.83773045
106Proteoglycans in cancer_Homo sapiens_hsa052050.83595047
107Folate biosynthesis_Homo sapiens_hsa007900.81269265
108Rap1 signaling pathway_Homo sapiens_hsa040150.81262641
109Thyroid cancer_Homo sapiens_hsa052160.80213864
110Insulin signaling pathway_Homo sapiens_hsa049100.80206348
111Thyroid hormone signaling pathway_Homo sapiens_hsa049190.79563175
112Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.77593836
113Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.77536653
114Parkinsons disease_Homo sapiens_hsa050120.76990337
115Vitamin B6 metabolism_Homo sapiens_hsa007500.76780759
116Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.76462525
117Notch signaling pathway_Homo sapiens_hsa043300.76093395
118Alcoholism_Homo sapiens_hsa050340.75957557
119Focal adhesion_Homo sapiens_hsa045100.75327493
120cGMP-PKG signaling pathway_Homo sapiens_hsa040220.75190836
121Pyruvate metabolism_Homo sapiens_hsa006200.74676334
122Shigellosis_Homo sapiens_hsa051310.73975188
123Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.73477262
124Central carbon metabolism in cancer_Homo sapiens_hsa052300.73306220
125Calcium signaling pathway_Homo sapiens_hsa040200.73056532
126Ras signaling pathway_Homo sapiens_hsa040140.72028536
127MicroRNAs in cancer_Homo sapiens_hsa052060.71778603
128* mRNA surveillance pathway_Homo sapiens_hsa030150.71309179
129Epstein-Barr virus infection_Homo sapiens_hsa051690.69738707
130Taste transduction_Homo sapiens_hsa047420.69413355
131Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.68809740
132Type II diabetes mellitus_Homo sapiens_hsa049300.64680009
133Purine metabolism_Homo sapiens_hsa002300.63258018
134* AMPK signaling pathway_Homo sapiens_hsa041520.62525166
135Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.61144913
136Fanconi anemia pathway_Homo sapiens_hsa034600.59828228
137Platelet activation_Homo sapiens_hsa046110.59717734
138Thyroid hormone synthesis_Homo sapiens_hsa049180.58228874
139Viral myocarditis_Homo sapiens_hsa054160.57953088
140Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.57613829
141Viral carcinogenesis_Homo sapiens_hsa052030.56695246
142p53 signaling pathway_Homo sapiens_hsa041150.55771844
143Pancreatic cancer_Homo sapiens_hsa052120.55130073
144Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.53910448
145Vascular smooth muscle contraction_Homo sapiens_hsa042700.53423683
146B cell receptor signaling pathway_Homo sapiens_hsa046620.53109643
147Legionellosis_Homo sapiens_hsa051340.52803228
148AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.52598514
149Arginine and proline metabolism_Homo sapiens_hsa003300.51748437
150* TGF-beta signaling pathway_Homo sapiens_hsa043500.51294350
151Basal transcription factors_Homo sapiens_hsa030220.50805626
152Selenocompound metabolism_Homo sapiens_hsa004500.49499906
153Oxidative phosphorylation_Homo sapiens_hsa001900.45462556
154Prion diseases_Homo sapiens_hsa050200.43882126
155Fructose and mannose metabolism_Homo sapiens_hsa000510.43852127
156Huntingtons disease_Homo sapiens_hsa050160.43583548
157Sulfur relay system_Homo sapiens_hsa041220.42911492
158Propanoate metabolism_Homo sapiens_hsa006400.37571967
159Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.34712589
160Alzheimers disease_Homo sapiens_hsa050100.31475813
161Cardiac muscle contraction_Homo sapiens_hsa042600.28730828
162Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.27551450
163Apoptosis_Homo sapiens_hsa042100.27243076
164Phenylalanine metabolism_Homo sapiens_hsa003600.27066679

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