PPP2R1A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a constant regulatory subunit of protein phosphatase 2. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The constant regulatory subunit A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. This gene encodes an alpha isoform of the constant regulatory subunit A. Alternatively spliced transcript variants have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle exocytosis (GO:0016079)5.74534234
2regulation of short-term neuronal synaptic plasticity (GO:0048172)5.70320529
3synaptic vesicle maturation (GO:0016188)5.63363811
4synaptic vesicle docking involved in exocytosis (GO:0016081)5.31712946
5glutamate secretion (GO:0014047)5.29728036
6locomotory exploration behavior (GO:0035641)5.23167554
7positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.17860771
8vocalization behavior (GO:0071625)5.13829943
9regulation of synaptic vesicle exocytosis (GO:2000300)5.06269481
10regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.96847406
11positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.85901630
12neuron cell-cell adhesion (GO:0007158)4.65203403
13peptidyl-arginine omega-N-methylation (GO:0035247)4.64316637
14regulation of glutamate receptor signaling pathway (GO:1900449)4.62477898
15protein localization to synapse (GO:0035418)4.57775286
16positive regulation of synapse maturation (GO:0090129)4.56100155
17Golgi transport vesicle coating (GO:0048200)4.49851564
18COPI coating of Golgi vesicle (GO:0048205)4.49851564
19layer formation in cerebral cortex (GO:0021819)4.45719479
20regulation of synapse structural plasticity (GO:0051823)4.40319470
21regulation of synaptic vesicle transport (GO:1902803)4.37097385
22neurotransmitter secretion (GO:0007269)4.35850225
23exploration behavior (GO:0035640)4.27004504
24negative regulation of microtubule polymerization (GO:0031115)4.15412152
25establishment of mitochondrion localization (GO:0051654)4.03895796
26regulation of neuronal synaptic plasticity (GO:0048168)3.99744936
27histone arginine methylation (GO:0034969)3.98219734
28retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.97162733
29regulation of long-term neuronal synaptic plasticity (GO:0048169)3.95435705
30peptidyl-arginine methylation (GO:0018216)3.94104056
31peptidyl-arginine N-methylation (GO:0035246)3.94104056
32regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.91540436
33neurotransmitter-gated ion channel clustering (GO:0072578)3.83508298
34ionotropic glutamate receptor signaling pathway (GO:0035235)3.77722425
35dendritic spine morphogenesis (GO:0060997)3.72794188
36regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)3.72254906
37synaptic transmission, glutamatergic (GO:0035249)3.68907983
38neuron recognition (GO:0008038)3.67121155
39cell migration in hindbrain (GO:0021535)3.63997410
40neuronal action potential propagation (GO:0019227)3.62710968
41neuron-neuron synaptic transmission (GO:0007270)3.59443332
42proline transport (GO:0015824)3.58851474
43axonal fasciculation (GO:0007413)3.52815779
44protein retention in ER lumen (GO:0006621)3.50744272
45regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.47642888
46activation of protein kinase A activity (GO:0034199)3.46082270
47regulation of synapse maturation (GO:0090128)3.44459927
48glycolytic process (GO:0006096)3.41918041
49positive regulation of membrane potential (GO:0045838)3.40538251
50membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.38156851
51glutamate receptor signaling pathway (GO:0007215)3.37858190
52postsynaptic membrane organization (GO:0001941)3.36546237
53regulation of synaptic plasticity (GO:0048167)3.34707945
54long-term synaptic potentiation (GO:0060291)3.34086570
55positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.34036672
56neurotransmitter transport (GO:0006836)3.33811118
57protein insertion into membrane (GO:0051205)3.33751884
58synaptic vesicle endocytosis (GO:0048488)3.31459721
59pyrimidine nucleobase catabolic process (GO:0006208)3.30669201
60regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.27956803
61response to pheromone (GO:0019236)3.27351397
62gamma-aminobutyric acid transport (GO:0015812)3.26579603
63positive regulation of synaptic transmission, GABAergic (GO:0032230)3.25313359
64maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.25004617
65regulation of excitatory postsynaptic membrane potential (GO:0060079)3.24303840
66long-term memory (GO:0007616)3.23536139
67cellular potassium ion homeostasis (GO:0030007)3.22882460
68auditory behavior (GO:0031223)3.22419863
69neuromuscular process controlling balance (GO:0050885)3.21935010
70regulation of neurotransmitter secretion (GO:0046928)3.19895025
71sodium ion export (GO:0071436)3.19684135
72establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.17661821
73mitochondrion transport along microtubule (GO:0047497)3.17661821
74cerebellar granule cell differentiation (GO:0021707)3.16890467
75positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.13250577
76regulation of postsynaptic membrane potential (GO:0060078)3.11666686
77cell communication by electrical coupling (GO:0010644)3.10555685
78response to auditory stimulus (GO:0010996)3.10420346
79regulation of neurotransmitter levels (GO:0001505)3.09658951
80cerebellar Purkinje cell layer development (GO:0021680)3.09378815
81dendrite morphogenesis (GO:0048813)3.07384440
82regulation of synaptic transmission, glutamatergic (GO:0051966)3.07322397
83cerebellar Purkinje cell differentiation (GO:0021702)3.07304016
84ATP hydrolysis coupled proton transport (GO:0015991)3.06774763
85energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.06774763
86dendritic spine organization (GO:0097061)3.04921661
87negative regulation of synaptic transmission, GABAergic (GO:0032229)3.04311982
88gluconeogenesis (GO:0006094)3.01505509
89vesicle transport along microtubule (GO:0047496)3.01285101
90neuronal ion channel clustering (GO:0045161)2.99116061
91G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.98565188
92regulation of neurotransmitter transport (GO:0051588)2.98067960
93regulation of vesicle fusion (GO:0031338)2.97212054
94positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.97083902
95transferrin transport (GO:0033572)2.96886780
96innervation (GO:0060384)2.95958588
97proline biosynthetic process (GO:0006561)2.95870766
98negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.95369364
99organelle transport along microtubule (GO:0072384)2.95245357
100gamma-aminobutyric acid signaling pathway (GO:0007214)2.95222213
101establishment of nucleus localization (GO:0040023)2.94110890
102membrane hyperpolarization (GO:0060081)2.93732456
103synapse assembly (GO:0007416)2.93659217
104transmission of nerve impulse (GO:0019226)2.93395122
105neuromuscular process controlling posture (GO:0050884)2.93253029
106cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.91651785
107protein maturation by protein folding (GO:0022417)2.89897784
108clathrin coat assembly (GO:0048268)2.89303758
109regulation of dendritic spine morphogenesis (GO:0061001)2.88973406
110positive regulation of neurotransmitter transport (GO:0051590)2.88759344
111establishment of synaptic vesicle localization (GO:0097480)2.87885004
112synaptic vesicle transport (GO:0048489)2.87885004
113neuromuscular process (GO:0050905)2.85886212
114positive regulation of synapse assembly (GO:0051965)2.85873581
115positive regulation of synaptic transmission (GO:0050806)2.85612522
116cytoskeletal anchoring at plasma membrane (GO:0007016)2.85534565
117mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.82997448
118regulation of synaptic transmission (GO:0050804)2.82600164
119synapse organization (GO:0050808)2.81667411
120adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.81559808
121establishment of integrated proviral latency (GO:0075713)2.80986904
122synaptic transmission (GO:0007268)2.80353510
123learning (GO:0007612)2.80086888
124behavioral defense response (GO:0002209)2.79924659
125hexose biosynthetic process (GO:0019319)2.74857674
126amino acid import (GO:0043090)2.74258140
127monosaccharide biosynthetic process (GO:0046364)2.70996629
128growth hormone secretion (GO:0030252)2.69781991
129establishment of viral latency (GO:0019043)2.69616190
130glucose 6-phosphate metabolic process (GO:0051156)2.69269165
131positive regulation of mitochondrial fission (GO:0090141)2.63878281
132de novo posttranslational protein folding (GO:0051084)2.62550741
133negative regulation of cell size (GO:0045792)2.61133743
134spliceosomal tri-snRNP complex assembly (GO:0000244)2.58342812
135regulation of mammary gland epithelial cell proliferation (GO:0033599)2.55548680
136nucleobase catabolic process (GO:0046113)2.53687973
137protein-DNA complex disassembly (GO:0032986)2.48814775
138nucleosome disassembly (GO:0006337)2.48814775
139axon extension (GO:0048675)2.47215418
140planar cell polarity pathway involved in neural tube closure (GO:0090179)2.45176324
141NADH metabolic process (GO:0006734)2.42742144
142de novo protein folding (GO:0006458)2.42304618
143neuron projection extension (GO:1990138)2.37734467
144adenine nucleotide transport (GO:0051503)2.36142433
145mating behavior (GO:0007617)2.35865447
146cullin deneddylation (GO:0010388)2.35286548
147tricarboxylic acid cycle (GO:0006099)2.35077282
148positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.30353264
149establishment of vesicle localization (GO:0051650)2.29647899
150intracellular estrogen receptor signaling pathway (GO:0030520)2.29537530
151pyruvate metabolic process (GO:0006090)2.29200526
152hippocampus development (GO:0021766)2.27736774
153cell communication involved in cardiac conduction (GO:0086065)2.26761279
154regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.26651610
155mitochondrial fusion (GO:0008053)2.25848284

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.81628686
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.11249834
3GBX2_23144817_ChIP-Seq_PC3_Human3.24123710
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.18818065
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.11154614
6RARB_27405468_Chip-Seq_BRAIN_Mouse3.01851875
7JARID2_20064375_ChIP-Seq_MESCs_Mouse3.01850318
8REST_21632747_ChIP-Seq_MESCs_Mouse3.00650367
9NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.95189069
10CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.90685582
11REST_18959480_ChIP-ChIP_MESCs_Mouse2.79293715
12EZH2_18974828_ChIP-Seq_MESCs_Mouse2.77000240
13RNF2_18974828_ChIP-Seq_MESCs_Mouse2.77000240
14JARID2_20075857_ChIP-Seq_MESCs_Mouse2.76523684
15NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.73878932
16EZH2_27304074_Chip-Seq_ESCs_Mouse2.72373615
17HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.64974483
18EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.64127242
19SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.56409211
20SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.55347318
21DROSHA_22980978_ChIP-Seq_HELA_Human2.50607093
22SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.49743422
23EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.49488533
24SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.48259834
25* CCND1_20090754_ChIP-ChIP_RETINA_Mouse2.45681826
26MTF2_20144788_ChIP-Seq_MESCs_Mouse2.43951429
27MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.43392502
28EZH2_27294783_Chip-Seq_ESCs_Mouse2.34989676
29SUZ12_27294783_Chip-Seq_ESCs_Mouse2.34089299
30IKZF1_21737484_ChIP-ChIP_HCT116_Human2.33399999
31EED_16625203_ChIP-ChIP_MESCs_Mouse2.30597641
32RNF2_27304074_Chip-Seq_ESCs_Mouse2.27697340
33ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.25851236
34SRY_22984422_ChIP-ChIP_TESTIS_Rat2.25541479
35THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.20111853
36ZNF263_19887448_ChIP-Seq_K562_Human2.19574233
37MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.15513504
38ZFP281_18757296_ChIP-ChIP_E14_Mouse2.12565471
39POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.04300205
40XRN2_22483619_ChIP-Seq_HELA_Human1.83689165
41ERG_21242973_ChIP-ChIP_JURKAT_Human1.79380970
42GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.77449340
43MYC_18555785_ChIP-Seq_MESCs_Mouse1.71832852
44DNAJC2_21179169_ChIP-ChIP_NT2_Human1.70420788
45CTBP2_25329375_ChIP-Seq_LNCAP_Human1.69716292
46PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.67846879
47KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.66794020
48AR_21572438_ChIP-Seq_LNCaP_Human1.66696832
49TET1_21451524_ChIP-Seq_MESCs_Mouse1.66075916
50JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.66073282
51YY1_21170310_ChIP-Seq_MESCs_Mouse1.65882501
52ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.63929218
53PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.60792274
54DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.60376671
55ZNF274_21170338_ChIP-Seq_K562_Hela1.59654849
56* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.58983339
57ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.58784037
58TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.57614491
59RARG_19884340_ChIP-ChIP_MEFs_Mouse1.57375744
60* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.55287011
61CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.55143863
62NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.54682083
63CLOCK_20551151_ChIP-Seq_293T_Human1.54284206
64* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.52461218
65* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.51307328
66NELFA_20434984_ChIP-Seq_ESCs_Mouse1.50694990
67RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.50493352
68PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.50449385
69RING1B_27294783_Chip-Seq_ESCs_Mouse1.47252722
70* PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.45445147
71EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.45128798
72RACK7_27058665_Chip-Seq_MCF-7_Human1.43828399
73MYC_19079543_ChIP-ChIP_MESCs_Mouse1.41931380
74SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.40262985
75CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.39586063
76NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.39363282
77CTBP1_25329375_ChIP-Seq_LNCAP_Human1.39018794
78ELK3_25401928_ChIP-Seq_HUVEC_Human1.35745225
79CREB1_15753290_ChIP-ChIP_HEK293T_Human1.35086516
80NANOG_18555785_ChIP-Seq_MESCs_Mouse1.32924777
81OCT4_18692474_ChIP-Seq_MEFs_Mouse1.32645181
82NR3C1_23031785_ChIP-Seq_PC12_Mouse1.32433282
83POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.30210566
84KDM2B_26808549_Chip-Seq_K562_Human1.29388818
85SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.28875568
86* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.28706151
87SOX2_21211035_ChIP-Seq_LN229_Gbm1.28672282
88DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.28303936
89P68_20966046_ChIP-Seq_HELA_Human1.27795418
90TAF15_26573619_Chip-Seq_HEK293_Human1.27023529
91UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.26999608
92KLF4_18555785_ChIP-Seq_MESCs_Mouse1.25865413
93GABP_19822575_ChIP-Seq_HepG2_Human1.25178151
94* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.25155075
95OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.23839458
96RING1B_27294783_Chip-Seq_NPCs_Mouse1.22652347
97ETS1_20019798_ChIP-Seq_JURKAT_Human1.20922561
98SMAD4_21799915_ChIP-Seq_A2780_Human1.20389057
99TP63_17297297_ChIP-ChIP_HaCaT_Human1.18974682
100CTCF_18555785_ChIP-Seq_MESCs_Mouse1.18753914
101SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.18298457
102* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.17817666
103CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.17462547
104* AR_19668381_ChIP-Seq_PC3_Human1.17403271
105TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.17027172
106ZFP281_27345836_Chip-Seq_ESCs_Mouse1.16321567
107RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.14992352
108TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.13351984
109CBX2_27304074_Chip-Seq_ESCs_Mouse1.12500351
110SA1_27219007_Chip-Seq_ERYTHROID_Human1.12311569
111DCP1A_22483619_ChIP-Seq_HELA_Human1.10645275
112TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.10494350
113NANOG_21062744_ChIP-ChIP_HESCs_Human1.10036390
114SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.09596375
115WT1_25993318_ChIP-Seq_PODOCYTE_Human1.09404955
116SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.08459520
117FOXP1_21924763_ChIP-Seq_HESCs_Human1.08097784
118PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.08093156
119RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.06197046
120* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse1.05422282
121P53_22127205_ChIP-Seq_FIBROBLAST_Human1.05379991
122YAP1_20516196_ChIP-Seq_MESCs_Mouse1.05073466
123TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse1.04878966
124BMI1_23680149_ChIP-Seq_NPCS_Mouse1.04408555
125TET1_21490601_ChIP-Seq_MESCs_Mouse1.03777326
126TP53_20018659_ChIP-ChIP_R1E_Mouse1.03338840
127CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.03201532
128CREB1_26743006_Chip-Seq_LNCaP_Human1.02988092
129GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02182296
130TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.01970096
131MYCN_18555785_ChIP-Seq_MESCs_Mouse1.01486212
132DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.00818780
133ESR1_15608294_ChIP-ChIP_MCF-7_Human1.00421694
134RNF2_27304074_Chip-Seq_NSC_Mouse1.00184864
135CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.99946126
136SMAD3_21741376_ChIP-Seq_ESCs_Human0.98970729
137TP53_22127205_ChIP-Seq_IMR90_Human0.98819173
138SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.98604621
139OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.97753047
140TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.97680466
141* HIF1A_21447827_ChIP-Seq_MCF-7_Human0.97096959
142AR_25329375_ChIP-Seq_VCAP_Human0.96036258
143SMAD3_21741376_ChIP-Seq_EPCs_Human0.95191760
144TOP2B_26459242_ChIP-Seq_MCF-7_Human0.94882567
145TRIM28_21343339_ChIP-Seq_HEK293_Human0.94744333
146TBX5_21415370_ChIP-Seq_HL-1_Mouse0.94683307
147P300_27058665_Chip-Seq_ZR-75-30cells_Human0.94552159
148SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.94434457
149ELF1_20517297_ChIP-Seq_JURKAT_Human0.94115995
150CTCF_27219007_Chip-Seq_ERYTHROID_Human0.93585305
151SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.93142514
152CTCF_27219007_Chip-Seq_Bcells_Human0.91774753
153SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.90692513
154MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.89700133
155P300_19829295_ChIP-Seq_ESCs_Human0.89589764
156SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.88329907
157VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.87888126
158KDM2B_26808549_Chip-Seq_SUP-B15_Human0.86781284
159* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.84450201
160THAP11_20581084_ChIP-Seq_MESCs_Mouse0.84407284
161EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.83358982
162STAT3_23295773_ChIP-Seq_U87_Human0.79839515
163SMAD4_21741376_ChIP-Seq_HESCs_Human0.79470744
164SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.79286278
165* SOX9_26525672_Chip-Seq_HEART_Mouse0.78865351
166SMAD4_21741376_ChIP-Seq_ESCs_Human0.78329175
167ARNT_22903824_ChIP-Seq_MCF-7_Human0.78212915
168LXR_22292898_ChIP-Seq_THP-1_Human0.76796304
169AHR_22903824_ChIP-Seq_MCF-7_Human0.76359686
170* SMC4_20622854_ChIP-Seq_HELA_Human0.76281002

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.96762623
2MP0003880_abnormal_central_pattern4.42574035
3MP0003635_abnormal_synaptic_transmissio3.85646910
4MP0004270_analgesia3.46841029
5MP0002063_abnormal_learning/memory/cond3.13308890
6MP0009745_abnormal_behavioral_response3.01424872
7MP0002064_seizures2.94099190
8MP0001968_abnormal_touch/_nociception2.89252569
9MP0009046_muscle_twitch2.69241981
10MP0005423_abnormal_somatic_nervous2.55006836
11MP0002572_abnormal_emotion/affect_behav2.53578757
12MP0002734_abnormal_mechanical_nocicepti2.52999674
13MP0002736_abnormal_nociception_after2.41240504
14MP0002822_catalepsy2.41205576
15MP0003122_maternal_imprinting2.36544667
16MP0004858_abnormal_nervous_system2.34323541
17MP0002272_abnormal_nervous_system2.22252937
18MP0002735_abnormal_chemical_nociception2.22066826
19MP0010030_abnormal_orbit_morphology2.21507592
20MP0000778_abnormal_nervous_system2.17507534
21MP0009780_abnormal_chondrocyte_physiolo2.09615779
22MP0002733_abnormal_thermal_nociception2.07000065
23MP0001486_abnormal_startle_reflex2.03961159
24MP0002184_abnormal_innervation1.99207090
25MP0004811_abnormal_neuron_physiology1.94966472
26MP0001440_abnormal_grooming_behavior1.90138379
27MP0001970_abnormal_pain_threshold1.89770179
28MP0003329_amyloid_beta_deposits1.88016044
29MP0006276_abnormal_autonomic_nervous1.81594647
30MP0002067_abnormal_sensory_capabilities1.79448890
31MP0001529_abnormal_vocalization1.78352861
32MP0008260_abnormal_autophagy1.76334357
33MP0008569_lethality_at_weaning1.71785516
34MP0000955_abnormal_spinal_cord1.70352160
35MP0002557_abnormal_social/conspecific_i1.66856114
36MP0002909_abnormal_adrenal_gland1.65805112
37MP0001501_abnormal_sleep_pattern1.63305951
38MP0004924_abnormal_behavior1.61385252
39MP0005386_behavior/neurological_phenoty1.61385252
40MP0003787_abnormal_imprinting1.59188419
41MP0001984_abnormal_olfaction1.57535794
42MP0000566_synostosis1.51979364
43MP0002882_abnormal_neuron_morphology1.49605028
44MP0002653_abnormal_ependyma_morphology1.48907107
45MP0003283_abnormal_digestive_organ1.39620215
46MP0003879_abnormal_hair_cell1.38791820
47MP0002066_abnormal_motor_capabilities/c1.37253433
48MP0005646_abnormal_pituitary_gland1.37031119
49MP0001849_ear_inflammation1.36873820
50MP0005645_abnormal_hypothalamus_physiol1.36847377
51MP0004233_abnormal_muscle_weight1.35583563
52MP0000751_myopathy1.34384696
53MP0002249_abnormal_larynx_morphology1.33127901
54MP0003705_abnormal_hypodermis_morpholog1.32906528
55MP0000750_abnormal_muscle_regeneration1.32837073
56MP0009672_abnormal_birth_weight1.31923432
57MP0002152_abnormal_brain_morphology1.26503937
58MP0004272_abnormal_basement_membrane1.23507017
59MP0005499_abnormal_olfactory_system1.22517661
60MP0005394_taste/olfaction_phenotype1.22517661
61MP0000013_abnormal_adipose_tissue1.19846157
62MP0000579_abnormal_nail_morphology1.19265067
63MP0004885_abnormal_endolymph1.17455033
64MP0001905_abnormal_dopamine_level1.16628876
65MP0003385_abnormal_body_wall1.15729417
66MP0010234_abnormal_vibrissa_follicle1.14062731
67MP0000049_abnormal_middle_ear1.12371922
68MP0000747_muscle_weakness1.11634892
69MP0008932_abnormal_embryonic_tissue1.09112969
70MP0003123_paternal_imprinting1.08492844
71MP0001502_abnormal_circadian_rhythm1.07268190
72MP0001346_abnormal_lacrimal_gland1.06808237
73MP0003121_genomic_imprinting1.05184551
74MP0000462_abnormal_digestive_system1.03587532
75MP0004142_abnormal_muscle_tone1.03141539
76MP0000749_muscle_degeneration1.02617453
77MP0003221_abnormal_cardiomyocyte_apopto1.00148648
78MP0005623_abnormal_meninges_morphology0.99693526
79MP0001188_hyperpigmentation0.96534187
80MP0003633_abnormal_nervous_system0.96091377
81MP0002837_dystrophic_cardiac_calcinosis0.95705883
82MP0003634_abnormal_glial_cell0.95283708
83MP0005257_abnormal_intraocular_pressure0.94811890
84MP0008961_abnormal_basal_metabolism0.94155308
85MP0008438_abnormal_cutaneous_collagen0.92612373
86MP0003631_nervous_system_phenotype0.91861699
87MP0002069_abnormal_eating/drinking_beha0.91517263
88MP0003861_abnormal_nervous_system0.90806027
89MP0001730_embryonic_growth_arrest0.88131137
90MP0000631_abnormal_neuroendocrine_gland0.87406315
91MP0002234_abnormal_pharynx_morphology0.85374537
92MP0000537_abnormal_urethra_morphology0.84696079
93MP0000759_abnormal_skeletal_muscle0.84071853
94MP0002751_abnormal_autonomic_nervous0.83851381
95MP0003566_abnormal_cell_adhesion0.83657668
96MP0003942_abnormal_urinary_system0.83426372
97MP0002752_abnormal_somatic_nervous0.81806743
98MP0000003_abnormal_adipose_tissue0.81398919
99MP0003632_abnormal_nervous_system0.81041686
100MP0010386_abnormal_urinary_bladder0.80068067
101MP0003111_abnormal_nucleus_morphology0.78716254
102MP0005501_abnormal_skin_physiology0.78380963
103MP0000762_abnormal_tongue_morphology0.78164743
104MP0004087_abnormal_muscle_fiber0.77214181
105MP0003938_abnormal_ear_development0.77064513
106MP0000467_abnormal_esophagus_morphology0.76960062
107MP0002229_neurodegeneration0.76509923
108MP0004085_abnormal_heartbeat0.75613230
109MP0002081_perinatal_lethality0.75285475
110MP0003115_abnormal_respiratory_system0.75059069
111MP0006035_abnormal_mitochondrial_morpho0.74507789
112MP0000534_abnormal_ureter_morphology0.73142678
113MP0001299_abnormal_eye_distance/0.72037235
114MP0005330_cardiomyopathy0.71830339
115MP0008789_abnormal_olfactory_epithelium0.71338622
116MP0004215_abnormal_myocardial_fiber0.69482744
117MP0005171_absent_coat_pigmentation0.69232732
118MP0003119_abnormal_digestive_system0.67645144
119MP0001943_abnormal_respiration0.67475005
120MP0001963_abnormal_hearing_physiology0.67339655
121MP0004145_abnormal_muscle_electrophysio0.66995074
122MP0000604_amyloidosis0.66606151
123MP0003183_abnormal_peptide_metabolism0.65668167
124MP0003137_abnormal_impulse_conducting0.65246216
125MP0008872_abnormal_physiological_respon0.65134841
126MP0002089_abnormal_postnatal_growth/wei0.63990806
127MP0010769_abnormal_survival0.63138905
128MP0005187_abnormal_penis_morphology0.62566883
129MP0002090_abnormal_vision0.62130909
130MP0004742_abnormal_vestibular_system0.62041824
131MP0002082_postnatal_lethality0.61487595
132MP0010770_preweaning_lethality0.61487595
133MP0000569_abnormal_digit_pigmentation0.59739568
134MP0002638_abnormal_pupillary_reflex0.59453080
135MP0010768_mortality/aging0.59142901
136MP0001177_atelectasis0.59123332
137MP0004133_heterotaxia0.57849883
138MP0001664_abnormal_digestion0.57175853

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.95452948
2Myokymia (HP:0002411)5.85050413
3Focal seizures (HP:0007359)4.74978453
4Visual hallucinations (HP:0002367)4.69976976
5Epileptic encephalopathy (HP:0200134)4.18979182
6Atonic seizures (HP:0010819)4.13661323
7Cholecystitis (HP:0001082)3.68031118
8Abnormal gallbladder physiology (HP:0012438)3.68031118
9Ankle clonus (HP:0011448)3.59217161
10Absence seizures (HP:0002121)3.43838019
11Progressive cerebellar ataxia (HP:0002073)3.42946019
12Febrile seizures (HP:0002373)3.25491261
13Upper limb amyotrophy (HP:0009129)3.19032809
14Distal upper limb amyotrophy (HP:0007149)3.19032809
15Supranuclear gaze palsy (HP:0000605)3.17762571
16Dialeptic seizures (HP:0011146)3.11730699
17Pheochromocytoma (HP:0002666)3.08895288
18Abnormal eating behavior (HP:0100738)3.07189244
19Impaired vibration sensation in the lower limbs (HP:0002166)3.05001510
20Hand muscle atrophy (HP:0009130)3.03113172
21Hyperacusis (HP:0010780)3.02985473
22Depression (HP:0000716)2.99172442
23Generalized tonic-clonic seizures (HP:0002069)2.97138537
24Failure to thrive in infancy (HP:0001531)2.94932944
25Polyphagia (HP:0002591)2.90316164
26Abnormality of the lower motor neuron (HP:0002366)2.86859812
27Action tremor (HP:0002345)2.86668682
28Lower limb amyotrophy (HP:0007210)2.86453869
29Cortical dysplasia (HP:0002539)2.81459485
30Amblyopia (HP:0000646)2.75162339
31Poor eye contact (HP:0000817)2.70217224
32Truncal ataxia (HP:0002078)2.70044207
33Broad-based gait (HP:0002136)2.69452446
34Neuroendocrine neoplasm (HP:0100634)2.69269558
35Abnormality of glycolysis (HP:0004366)2.69184415
36Urinary urgency (HP:0000012)2.69161092
37Limb dystonia (HP:0002451)2.68551172
38Distal lower limb amyotrophy (HP:0008944)2.67745161
39Mutism (HP:0002300)2.57978717
40Difficulty climbing stairs (HP:0003551)2.57959511
41Urinary bladder sphincter dysfunction (HP:0002839)2.55939105
42Insidious onset (HP:0003587)2.51108123
43Termporal pattern (HP:0011008)2.51108123
44Retinal dysplasia (HP:0007973)2.49824253
45Abnormal social behavior (HP:0012433)2.49772175
46Impaired social interactions (HP:0000735)2.49772175
47Hyperventilation (HP:0002883)2.48025416
48Amyotrophic lateral sclerosis (HP:0007354)2.43582806
49Spastic gait (HP:0002064)2.42564594
50Megalencephaly (HP:0001355)2.41273210
51Premature rupture of membranes (HP:0001788)2.37351017
52Anxiety (HP:0000739)2.36986660
53Epileptiform EEG discharges (HP:0011182)2.35690388
54Dysdiadochokinesis (HP:0002075)2.35049192
55Peripheral hypomyelination (HP:0007182)2.34981524
56Pointed chin (HP:0000307)2.34423776
57Exercise-induced muscle cramps (HP:0003710)2.32653006
58Fetal akinesia sequence (HP:0001989)2.29637009
59Neoplasm of the peripheral nervous system (HP:0100007)2.28613018
60EEG with generalized epileptiform discharges (HP:0011198)2.27289787
61Shoulder girdle muscle weakness (HP:0003547)2.26829744
62Hypoventilation (HP:0002791)2.26207090
63Split foot (HP:0001839)2.23946737
64Abnormality of the labia minora (HP:0012880)2.23534426
65Hammertoe (HP:0001765)2.23411598
66Torticollis (HP:0000473)2.23251498
67Abnormality of the hip-girdle musculature (HP:0001445)2.21470825
68Abnormality of the musculature of the pelvis (HP:0001469)2.21470825
69Hypsarrhythmia (HP:0002521)2.21409814
70Abnormality of the corticospinal tract (HP:0002492)2.21116504
71Hypoplasia of the brainstem (HP:0002365)2.20475424
72Aplasia/Hypoplasia of the brainstem (HP:0007362)2.20475424
73Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.20387766
74Genetic anticipation (HP:0003743)2.15795307
75Pelvic girdle muscle weakness (HP:0003749)2.13379182
76Spastic diplegia (HP:0001264)2.13149031
77Back pain (HP:0003418)2.12394461
78Progressive inability to walk (HP:0002505)2.12338130
79Lissencephaly (HP:0001339)2.12144569
80Broad distal phalanx of finger (HP:0009836)2.12066476
81Focal dystonia (HP:0004373)2.09979314
82Diplopia (HP:0000651)2.09869915
83Abnormality of binocular vision (HP:0011514)2.09869915
84Limb-girdle muscle atrophy (HP:0003797)2.09563466
85Lower limb muscle weakness (HP:0007340)2.09294071
86Excessive salivation (HP:0003781)2.09194754
87Drooling (HP:0002307)2.09194754
88Hemiplegia (HP:0002301)2.07944720
89Dysmetria (HP:0001310)2.07785303
90Overriding aorta (HP:0002623)2.07554206
91Poor suck (HP:0002033)2.07247858
92Centrally nucleated skeletal muscle fibers (HP:0003687)2.06607581
93Impaired smooth pursuit (HP:0007772)2.06295537
94Gaze-evoked nystagmus (HP:0000640)2.06064924
95Shallow orbits (HP:0000586)2.05894833
96Akinesia (HP:0002304)2.05689434
97Specific learning disability (HP:0001328)2.04113807
98Hemiparesis (HP:0001269)2.01776137
99Neuronal loss in central nervous system (HP:0002529)2.01539883
100Insomnia (HP:0100785)2.01016981
101Heterochromia iridis (HP:0001100)2.00505332
102Stereotypic behavior (HP:0000733)2.00365431
103Postural instability (HP:0002172)2.00327674
104Neoplasm of the heart (HP:0100544)1.98915754
105Generalized hypotonia (HP:0001290)1.98131494
106Impaired pain sensation (HP:0007328)1.97701556
107Abnormality of pain sensation (HP:0010832)1.97701556
108Upper limb muscle weakness (HP:0003484)1.97107567
109Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.96475335
110Cerebral inclusion bodies (HP:0100314)1.95742003
111Turricephaly (HP:0000262)1.95397340
112Agitation (HP:0000713)1.94490843
113Annular pancreas (HP:0001734)1.93275987
114Myopathic facies (HP:0002058)1.93019497
115Bradykinesia (HP:0002067)1.92838889
116Scanning speech (HP:0002168)1.92774619
117Limb-girdle muscle weakness (HP:0003325)1.91337388
118Increased serum pyruvate (HP:0003542)1.90960704
119Abnormality of the motor neurons (HP:0002450)1.89010343
120Abnormal neuron morphology (HP:0012757)1.89010343
121Diminished motivation (HP:0000745)1.88841808
122Craniofacial dystonia (HP:0012179)1.88448593
123Papilledema (HP:0001085)1.88428113
124Dysmetric saccades (HP:0000641)1.86233198
125Hypokinesia (HP:0002375)1.85941655
126Neurofibrillary tangles (HP:0002185)1.85646473
127Distal sensory impairment (HP:0002936)1.85283163
128Long palpebral fissure (HP:0000637)1.84603360
129Abnormal hair whorl (HP:0010721)1.83510964
130Trigonocephaly (HP:0000243)1.83085164
131Mildly elevated creatine phosphokinase (HP:0008180)1.83028294
132Resting tremor (HP:0002322)1.81542136
133Achilles tendon contracture (HP:0001771)1.80941994
134Spinal rigidity (HP:0003306)1.80083870
135Apathy (HP:0000741)1.79762275
136Gait imbalance (HP:0002141)1.79729284
137Cholelithiasis (HP:0001081)1.79317527
138Clonus (HP:0002169)1.78973878
139Abnormality of ocular smooth pursuit (HP:0000617)1.78774905
140Spinal canal stenosis (HP:0003416)1.77292745
141Ventricular fibrillation (HP:0001663)1.77192444
142Ragged-red muscle fibers (HP:0003200)1.76676304
143Intellectual disability, profound (HP:0002187)1.76409706
144Delusions (HP:0000746)1.76369025
145Bronchomalacia (HP:0002780)1.76219018
146Narrow nasal bridge (HP:0000446)1.75303004
147Cerebral hypomyelination (HP:0006808)1.74736909
148Distal lower limb muscle weakness (HP:0009053)1.73378973
149Choanal stenosis (HP:0000452)1.70656586
150Hypercortisolism (HP:0001578)1.70496448
151Incomplete penetrance (HP:0003829)1.69501657
152Elfin facies (HP:0004428)1.68519565
153Atrophy/Degeneration involving motor neurons (HP:0007373)1.67671262
154Aplasia involving bones of the extremities (HP:0009825)1.67321993
155Aplasia involving bones of the upper limbs (HP:0009823)1.67321993
156Aplasia of the phalanges of the hand (HP:0009802)1.67321993
157Adducted thumb (HP:0001181)1.67034800
158Precocious puberty (HP:0000826)1.64203416
159Ulnar bowing (HP:0003031)1.64013072
160High anterior hairline (HP:0009890)1.59860077
161Abnormal gallbladder morphology (HP:0012437)1.57945079
162CNS hypomyelination (HP:0003429)1.57814624
163Microvesicular hepatic steatosis (HP:0001414)1.57810372
164Stridor (HP:0010307)1.57642823
165Foot dorsiflexor weakness (HP:0009027)1.57196994

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K93.86014070
2MARK13.75008991
3NTRK33.58608838
4EPHA43.08636776
5MINK13.07627036
6MAP3K42.85308928
7MAP3K122.78427707
8DAPK22.43192956
9SMG12.37569062
10KSR12.30103312
11PAK62.28951372
12MAP2K72.19319771
13KSR22.16850884
14NTRK22.13010440
15CDK192.03371697
16CASK1.98197199
17DAPK11.86534434
18NEK11.72776129
19BCKDK1.71472698
20PRKD31.66407447
21EPHA21.65948720
22VRK21.65868851
23UHMK11.65324533
24NTRK11.62054311
25MAP2K41.59470473
26PLK21.59369981
27MAPK131.55037734
28BUB11.51463832
29CSNK1A1L1.48437443
30ARAF1.48374512
31CAMKK11.47884021
32CDK51.47518529
33PRPF4B1.44801727
34EEF2K1.43954415
35TYRO31.43486855
36TSSK61.41971924
37PIM21.38335821
38SIK31.36670121
39CDK181.33634363
40PAK41.31987911
41CDK141.27407339
42LIMK11.25575957
43CDK151.25363764
44SRPK11.23871014
45LATS21.21005778
46CCNB11.18981798
47PRKCG1.15420997
48PHKG11.14596817
49PHKG21.14596817
50CSNK1G11.13279435
51CDK11A1.11729090
52TRIM281.08237032
53BCR1.07512485
54GRK51.06543973
55SIK10.99367705
56TTN0.99043893
57SIK20.94177086
58NME20.92186783
59CAMK2G0.91310380
60PTK20.90300891
61PKN20.89412943
62PAK30.88130989
63LMTK20.87334925
64TAOK10.87080347
65PDGFRA0.86395264
66EPHB10.85645438
67MAP3K110.83346439
68MAP3K20.81395356
69SGK4940.80042923
70SGK2230.80042923
71RET0.79470907
72ALK0.78503603
73SCYL20.77582948
74ERBB30.76728398
75AURKA0.75208894
76CSNK1G20.73805574
77DYRK20.72495204
78DYRK1B0.72029697
79CAMKK20.71997253
80PNCK0.71723935
81FER0.70518648
82TNIK0.69662984
83CAMK2A0.69255065
84FES0.68540983
85WNK30.68306176
86TESK10.67375469
87TRIB30.66247144
88PRKCH0.65933282
89AKT20.65817311
90BRSK10.65642259
91STK380.64112616
92ROCK20.62867461
93TAOK20.62067068
94RAF10.62023448
95DAPK30.60447172
96RPS6KA20.59677117
97DYRK1A0.58956525
98OXSR10.57942442
99MAP2K10.56692160
100CAMK2B0.56574320
101CAMK2D0.55369669
102BRAF0.50116982
103EPHA30.50042281
104CAMK10.49254849
105EPHB20.48656454
106TESK20.48293367
107STK110.47909176
108PTK2B0.47752634
109KDR0.46888746
110FGFR10.46766498
111PRKCZ0.45940949
112RIPK40.44733764
113MET0.43596483
114ICK0.43230903
115PRKD20.42932037
116NME10.42919291
117PDK40.41940261
118PDK30.41940261
119CSNK1G30.41113242
120PRKCE0.40904518
121MARK20.40470867
122ROCK10.40400468
123FYN0.40100913
124ERBB40.39550777
125SGK20.39477253
126PAK10.38887822
127ILK0.38833001
128MAP3K10.38284672
129IRAK30.37913057
130CDC42BPA0.37857491
131MAP3K100.37593109
132MAPKAPK50.36964033
133SGK10.35569482
134RIPK10.34975207
135RPS6KA30.34913875
136CDK70.34471096
137MAP3K50.33889753
138MAPK100.33865455

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047213.97232355
2Nicotine addiction_Homo sapiens_hsa050333.15234685
3Biosynthesis of amino acids_Homo sapiens_hsa012302.48511104
4Olfactory transduction_Homo sapiens_hsa047402.48002044
5GABAergic synapse_Homo sapiens_hsa047272.47048997
6Circadian entrainment_Homo sapiens_hsa047132.40640306
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.34044732
8Long-term potentiation_Homo sapiens_hsa047202.31782975
9Collecting duct acid secretion_Homo sapiens_hsa049662.30582956
10Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.28321996
11Morphine addiction_Homo sapiens_hsa050322.18114479
12Glutamatergic synapse_Homo sapiens_hsa047242.11979575
13Amphetamine addiction_Homo sapiens_hsa050312.10548345
14* Dopaminergic synapse_Homo sapiens_hsa047282.09081648
15Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.86011033
16Carbon metabolism_Homo sapiens_hsa012001.85894404
17Vibrio cholerae infection_Homo sapiens_hsa051101.84189514
18Insulin secretion_Homo sapiens_hsa049111.82079806
19Cholinergic synapse_Homo sapiens_hsa047251.78816474
20Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.75058793
21Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.73488553
22Fructose and mannose metabolism_Homo sapiens_hsa000511.69698539
23Pentose phosphate pathway_Homo sapiens_hsa000301.67652879
24Salivary secretion_Homo sapiens_hsa049701.67215653
25Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.63831173
26Gastric acid secretion_Homo sapiens_hsa049711.59594378
27* Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.57097006
28Vitamin B6 metabolism_Homo sapiens_hsa007501.55552196
29Cocaine addiction_Homo sapiens_hsa050301.54730142
30Gap junction_Homo sapiens_hsa045401.52567523
31Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.50392270
32Aldosterone synthesis and secretion_Homo sapiens_hsa049251.49107727
33Oxytocin signaling pathway_Homo sapiens_hsa049211.48716659
34Base excision repair_Homo sapiens_hsa034101.48277305
35Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.44572435
36Serotonergic synapse_Homo sapiens_hsa047261.44174334
37Axon guidance_Homo sapiens_hsa043601.42030509
38Fatty acid elongation_Homo sapiens_hsa000621.37422644
39Taste transduction_Homo sapiens_hsa047421.36887761
40Sulfur relay system_Homo sapiens_hsa041221.36009717
41Renin secretion_Homo sapiens_hsa049241.35098428
42* Long-term depression_Homo sapiens_hsa047301.35014258
43Steroid biosynthesis_Homo sapiens_hsa001001.32875699
44GnRH signaling pathway_Homo sapiens_hsa049121.28661360
45Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.28341504
46Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.23761044
47Calcium signaling pathway_Homo sapiens_hsa040201.21314143
48Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.20127342
49Glioma_Homo sapiens_hsa052141.19843827
50Galactose metabolism_Homo sapiens_hsa000521.16970250
51Cyanoamino acid metabolism_Homo sapiens_hsa004601.16457110
52Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.14073757
53Estrogen signaling pathway_Homo sapiens_hsa049151.13763764
54Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.11339418
55* Oocyte meiosis_Homo sapiens_hsa041141.10941190
56ErbB signaling pathway_Homo sapiens_hsa040121.06643722
57Melanogenesis_Homo sapiens_hsa049161.05045309
58Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.04675115
59Arginine and proline metabolism_Homo sapiens_hsa003301.01568648
60Type II diabetes mellitus_Homo sapiens_hsa049300.99728144
61cAMP signaling pathway_Homo sapiens_hsa040240.97074783
62Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.95560190
63Pyruvate metabolism_Homo sapiens_hsa006200.95340056
64Cardiac muscle contraction_Homo sapiens_hsa042600.94263625
65Neurotrophin signaling pathway_Homo sapiens_hsa047220.93070232
66Phosphatidylinositol signaling system_Homo sapiens_hsa040700.89941412
67Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.88140454
68cGMP-PKG signaling pathway_Homo sapiens_hsa040220.87093516
69Proteasome_Homo sapiens_hsa030500.82556984
70DNA replication_Homo sapiens_hsa030300.77417294
71Colorectal cancer_Homo sapiens_hsa052100.77121596
72Endometrial cancer_Homo sapiens_hsa052130.76234737
73Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.75174464
74Dilated cardiomyopathy_Homo sapiens_hsa054140.74892712
75Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.73436636
76* Tight junction_Homo sapiens_hsa045300.73339857
772-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.73297669
78Alcoholism_Homo sapiens_hsa050340.72430159
79Endocytosis_Homo sapiens_hsa041440.71379660
80Phospholipase D signaling pathway_Homo sapiens_hsa040720.71123199
81VEGF signaling pathway_Homo sapiens_hsa043700.70026846
82* AMPK signaling pathway_Homo sapiens_hsa041520.69925836
83Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.69111585
84Vascular smooth muscle contraction_Homo sapiens_hsa042700.69073031
85MAPK signaling pathway_Homo sapiens_hsa040100.68337391
86Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.68139118
87mTOR signaling pathway_Homo sapiens_hsa041500.67673266
88Type I diabetes mellitus_Homo sapiens_hsa049400.66464777
89Thyroid hormone signaling pathway_Homo sapiens_hsa049190.66100210
90Renal cell carcinoma_Homo sapiens_hsa052110.64935780
91Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.62028794
92Spliceosome_Homo sapiens_hsa030400.60879851
93Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.60633868
94Cysteine and methionine metabolism_Homo sapiens_hsa002700.59741298
95Arginine biosynthesis_Homo sapiens_hsa002200.59599903
96Basal cell carcinoma_Homo sapiens_hsa052170.58845204
97Phototransduction_Homo sapiens_hsa047440.58513078
98Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.58511182
99Fatty acid metabolism_Homo sapiens_hsa012120.58481420
100Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.58413451
101Rap1 signaling pathway_Homo sapiens_hsa040150.57624490
102Phagosome_Homo sapiens_hsa041450.57171978
103Choline metabolism in cancer_Homo sapiens_hsa052310.56393918
104Adherens junction_Homo sapiens_hsa045200.56338368
105Folate biosynthesis_Homo sapiens_hsa007900.55520171
106Huntingtons disease_Homo sapiens_hsa050160.55223164
107Oxidative phosphorylation_Homo sapiens_hsa001900.54687926
108N-Glycan biosynthesis_Homo sapiens_hsa005100.54462937
109Hedgehog signaling pathway_Homo sapiens_hsa043400.53872806
110Central carbon metabolism in cancer_Homo sapiens_hsa052300.53565761
111Ras signaling pathway_Homo sapiens_hsa040140.53564013
112Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.53386082
113Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.53166808
114Thyroid hormone synthesis_Homo sapiens_hsa049180.53111772
115Insulin signaling pathway_Homo sapiens_hsa049100.52215749
116Non-small cell lung cancer_Homo sapiens_hsa052230.51885452
117Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.51739836
118Wnt signaling pathway_Homo sapiens_hsa043100.51663680
119Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.50008414
120Phenylalanine metabolism_Homo sapiens_hsa003600.49698026
121Glucagon signaling pathway_Homo sapiens_hsa049220.49627033
122Shigellosis_Homo sapiens_hsa051310.49468819
123Bladder cancer_Homo sapiens_hsa052190.49282525
124Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.49222619
125Pancreatic secretion_Homo sapiens_hsa049720.49050410
126Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.48682269
127* mRNA surveillance pathway_Homo sapiens_hsa030150.48623005
128Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.48510822
129Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.47821414
130* Hippo signaling pathway_Homo sapiens_hsa043900.47685745
131Alzheimers disease_Homo sapiens_hsa050100.47394313
132Parkinsons disease_Homo sapiens_hsa050120.45858155
133Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.44793595
134Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.43850000
135* Sphingolipid signaling pathway_Homo sapiens_hsa040710.43816932
136Dorso-ventral axis formation_Homo sapiens_hsa043200.43536524
137Rheumatoid arthritis_Homo sapiens_hsa053230.43113738
138Salmonella infection_Homo sapiens_hsa051320.42992342
139Prion diseases_Homo sapiens_hsa050200.42842114
140Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.41851408
141Carbohydrate digestion and absorption_Homo sapiens_hsa049730.40078755

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