PPP2R1B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a constant regulatory subunit of protein phosphatase 2. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The constant regulatory subunit A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. This gene encodes a beta isoform of the constant regulatory subunit A. Mutations in this gene have been associated with some lung and colon cancers. Alternatively spliced transcript variants have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA unwinding involved in DNA replication (GO:0006268)4.66504712
2nuclear pore organization (GO:0006999)4.35518007
3establishment of integrated proviral latency (GO:0075713)4.25009634
4folic acid-containing compound biosynthetic process (GO:0009396)4.24986316
5nuclear pore complex assembly (GO:0051292)4.16735753
6DNA strand elongation involved in DNA replication (GO:0006271)4.06827791
7IMP biosynthetic process (GO:0006188)4.05000787
8mitotic nuclear envelope disassembly (GO:0007077)4.00834696
9DNA replication initiation (GO:0006270)3.98228031
10protein localization to kinetochore (GO:0034501)3.92970086
11DNA strand elongation (GO:0022616)3.84619386
12DNA replication-dependent nucleosome organization (GO:0034723)3.78751479
13DNA replication-dependent nucleosome assembly (GO:0006335)3.78751479
14membrane disassembly (GO:0030397)3.74926560
15nuclear envelope disassembly (GO:0051081)3.74926560
16formation of translation preinitiation complex (GO:0001731)3.64827995
17nucleobase biosynthetic process (GO:0046112)3.61107383
18protein localization to chromosome, centromeric region (GO:0071459)3.60849833
19telomere maintenance via semi-conservative replication (GO:0032201)3.57011734
20L-serine metabolic process (GO:0006563)3.56271482
21double-strand break repair via nonhomologous end joining (GO:0006303)3.45476452
22non-recombinational repair (GO:0000726)3.45476452
23mitotic chromosome condensation (GO:0007076)3.43593372
24IMP metabolic process (GO:0046040)3.43316736
25mitotic metaphase plate congression (GO:0007080)3.38861199
26glycine metabolic process (GO:0006544)3.37453255
27somatic hypermutation of immunoglobulin genes (GO:0016446)3.37428111
28somatic diversification of immune receptors via somatic mutation (GO:0002566)3.37428111
29regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.34178034
30low-density lipoprotein particle clearance (GO:0034383)3.32882475
31regulation of mitotic spindle checkpoint (GO:1903504)3.30986802
32regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.30986802
33regulation of helicase activity (GO:0051095)3.26625492
34DNA double-strand break processing (GO:0000729)3.24176379
35telomere maintenance via recombination (GO:0000722)3.23867713
36spindle checkpoint (GO:0031577)3.22375351
37negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.20601335
38DNA replication checkpoint (GO:0000076)3.19897827
39DNA duplex unwinding (GO:0032508)3.19628945
40mitotic recombination (GO:0006312)3.19279104
41DNA geometric change (GO:0032392)3.17453769
42maturation of SSU-rRNA (GO:0030490)3.17398729
43mitotic spindle checkpoint (GO:0071174)3.17246928
44regulation of spindle organization (GO:0090224)3.16059211
45mitotic sister chromatid cohesion (GO:0007064)3.15322160
46serine family amino acid biosynthetic process (GO:0009070)3.14155887
47purine nucleobase biosynthetic process (GO:0009113)3.11822738
48urea metabolic process (GO:0019627)3.11263800
49attachment of spindle microtubules to kinetochore (GO:0008608)3.10597558
50proteasome assembly (GO:0043248)3.10133561
51pore complex assembly (GO:0046931)3.08942550
52ribosomal small subunit assembly (GO:0000028)3.08355413
53negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.08308029
54establishment of viral latency (GO:0019043)3.07550190
55regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.07421477
56metaphase plate congression (GO:0051310)3.07046128
57glyoxylate metabolic process (GO:0046487)3.05651853
58DNA ligation (GO:0006266)3.01617897
59heterochromatin organization (GO:0070828)3.01305003
60chromatin remodeling at centromere (GO:0031055)3.00624915
61protein complex localization (GO:0031503)2.98369339
62ribosome assembly (GO:0042255)2.96934975
63DNA replication-independent nucleosome organization (GO:0034724)2.96572017
64DNA replication-independent nucleosome assembly (GO:0006336)2.96572017
65CENP-A containing nucleosome assembly (GO:0034080)2.96548311
66nuclear envelope organization (GO:0006998)2.95114731
67urea cycle (GO:0000050)2.94138750
68imidazole-containing compound metabolic process (GO:0052803)2.93988582
69regulation of sister chromatid segregation (GO:0033045)2.93316049
70regulation of mitotic sister chromatid separation (GO:0010965)2.93316049
71regulation of mitotic sister chromatid segregation (GO:0033047)2.93316049
72telomere maintenance via telomere lengthening (GO:0010833)2.92207158
73DNA catabolic process, exonucleolytic (GO:0000738)2.91763426
74regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.90466970
75regulation of centriole replication (GO:0046599)2.89665807
76regulation of translational fidelity (GO:0006450)2.89494366
77negative regulation of RNA splicing (GO:0033119)2.89419854
78kinetochore organization (GO:0051383)2.87305638
79negative regulation of DNA-dependent DNA replication (GO:2000104)2.86905009
80complement activation, alternative pathway (GO:0006957)2.84768734
81regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.84708877
82regulation of mitotic spindle organization (GO:0060236)2.83923844
83pre-miRNA processing (GO:0031054)2.83126231
84mitotic sister chromatid segregation (GO:0000070)2.81515034
85negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.80950125
86sister chromatid segregation (GO:0000819)2.78950589
87positive regulation of chromosome segregation (GO:0051984)2.78926109
88L-phenylalanine catabolic process (GO:0006559)2.78707048
89erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.78707048
90DNA conformation change (GO:0071103)2.77757833
91cellular protein complex localization (GO:0034629)2.76995592
92ATP-dependent chromatin remodeling (GO:0043044)2.76906843
93establishment of chromosome localization (GO:0051303)2.76710726
94biotin metabolic process (GO:0006768)2.76264252
95regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.76005209
96lysine metabolic process (GO:0006553)2.75377669
97lysine catabolic process (GO:0006554)2.75377669
98DNA strand renaturation (GO:0000733)2.73944313
99ribosomal large subunit biogenesis (GO:0042273)2.73148848
100chromatin assembly or disassembly (GO:0006333)2.72896496
101negative regulation of DNA recombination (GO:0045910)2.72541056
102nitrogen cycle metabolic process (GO:0071941)2.72185156
103anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.71598772
104translesion synthesis (GO:0019985)2.71469917
105synapsis (GO:0007129)2.70882212
106regulation of histone H3-K9 methylation (GO:0051570)2.69986934
107ribosome biogenesis (GO:0042254)2.69863048
108histone exchange (GO:0043486)2.69190267
109tRNA aminoacylation for protein translation (GO:0006418)2.69045745
110nucleotide-excision repair, DNA gap filling (GO:0006297)2.67607154
111negative regulation of mRNA processing (GO:0050686)2.66443148
112translational termination (GO:0006415)2.66221421
113white fat cell differentiation (GO:0050872)2.65701139
114translational initiation (GO:0006413)2.65378741
115negative regulation of phagocytosis (GO:0050765)2.64880516
116protein localization to chromosome (GO:0034502)2.64321940
117chromosome condensation (GO:0030261)2.63783558
118viral transcription (GO:0019083)2.63053091
119valine metabolic process (GO:0006573)2.62878457
120postreplication repair (GO:0006301)2.62360059
121regulation of chromosome segregation (GO:0051983)2.60725616
122negative regulation of chromosome segregation (GO:0051985)2.59492866
123meiotic chromosome segregation (GO:0045132)2.58243117
124regulation of mitotic metaphase/anaphase transition (GO:0030071)2.57741131
125negative regulation of mitotic sister chromatid separation (GO:2000816)2.57725386
126negative regulation of mitotic sister chromatid segregation (GO:0033048)2.57725386
127negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.57725386
128negative regulation of sister chromatid segregation (GO:0033046)2.57725386
129spliceosomal snRNP assembly (GO:0000387)2.57384759
130translational elongation (GO:0006414)2.55658774
131regulation of centrosome cycle (GO:0046605)2.55556565
132tetrahydrofolate metabolic process (GO:0046653)2.54383488
133positive regulation of mitotic sister chromatid separation (GO:1901970)2.54225055
134positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.54225055
135positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.54225055
136ribonucleoprotein complex biogenesis (GO:0022613)2.53242221
137spindle assembly checkpoint (GO:0071173)2.52647771
138pentose-phosphate shunt (GO:0006098)2.52625290
139negative regulation of mRNA metabolic process (GO:1903312)2.52241251
140regulation of posttranscriptional gene silencing (GO:0060147)2.51595054
141regulation of gene silencing by miRNA (GO:0060964)2.51595054
142regulation of gene silencing by RNA (GO:0060966)2.51595054
143mitotic spindle assembly checkpoint (GO:0007094)2.51064995
144regulation of sister chromatid cohesion (GO:0007063)2.51051999
145mRNA splicing, via spliceosome (GO:0000398)2.50965426
146RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.50965426
147regulation of translational termination (GO:0006449)2.50781259

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.56407165
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.84992559
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.82542632
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.75709746
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.41156508
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.06443583
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.87014445
8MYC_19079543_ChIP-ChIP_MESCs_Mouse2.58915774
9EGR1_19374776_ChIP-ChIP_THP-1_Human2.52472483
10MYC_19030024_ChIP-ChIP_MESCs_Mouse2.43816666
11E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.39196265
12MYC_18358816_ChIP-ChIP_MESCs_Mouse2.36251541
13AR_21909140_ChIP-Seq_LNCAP_Human2.32490197
14* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.27638049
15KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.25720869
16EST1_17652178_ChIP-ChIP_JURKAT_Human2.22084601
17MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.18101613
18FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.13266510
19XRN2_22483619_ChIP-Seq_HELA_Human2.11729524
20CREB1_15753290_ChIP-ChIP_HEK293T_Human2.10830029
21MYC_22102868_ChIP-Seq_BL_Human2.08453640
22GABP_17652178_ChIP-ChIP_JURKAT_Human2.06727925
23ETS1_20019798_ChIP-Seq_JURKAT_Human2.04769912
24MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.04487176
25E2F1_21310950_ChIP-Seq_MCF-7_Human2.00707727
26JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.93080012
27PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.81551307
28VDR_23849224_ChIP-Seq_CD4+_Human1.79464908
29HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.76817106
30CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.73943224
31MYCN_18555785_ChIP-Seq_MESCs_Mouse1.73740057
32DCP1A_22483619_ChIP-Seq_HELA_Human1.71160948
33KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.70781018
34E2F1_18555785_ChIP-Seq_MESCs_Mouse1.70714281
35ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.70690494
36FOXP3_21729870_ChIP-Seq_TREG_Human1.69743854
37TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.69062479
38PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.66754768
39CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.65094642
40NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.62424170
41MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.61140619
42* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.60514087
43CIITA_25753668_ChIP-Seq_RAJI_Human1.57844405
44TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.57658967
45GABP_19822575_ChIP-Seq_HepG2_Human1.56546930
46CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.55432801
47* HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.53829786
48SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.53231097
49TTF2_22483619_ChIP-Seq_HELA_Human1.52812678
50ELF1_17652178_ChIP-ChIP_JURKAT_Human1.50350024
51ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.50183607
52NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.49746828
53POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.47857634
54EGR1_23403033_ChIP-Seq_LIVER_Mouse1.47732766
55ELK1_19687146_ChIP-ChIP_HELA_Human1.41426451
56CLOCK_20551151_ChIP-Seq_293T_Human1.40767954
57* NANOG_16153702_ChIP-ChIP_HESCs_Human1.40612406
58CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.40166166
59NANOG_18555785_ChIP-Seq_MESCs_Mouse1.39315901
60KDM5A_27292631_Chip-Seq_BREAST_Human1.37978637
61TFEB_21752829_ChIP-Seq_HELA_Human1.35123646
62SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.32304367
63TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.31657392
64YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.29350369
65FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.28434210
66HOXB4_20404135_ChIP-ChIP_EML_Mouse1.27543133
67THAP11_20581084_ChIP-Seq_MESCs_Mouse1.26799531
68STAT3_1855785_ChIP-Seq_MESCs_Mouse1.26092926
69KLF4_18555785_ChIP-Seq_MESCs_Mouse1.25542749
70MYC_18940864_ChIP-ChIP_HL60_Human1.23312571
71EWS_26573619_Chip-Seq_HEK293_Human1.22080190
72ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.19612331
73* SOX17_20123909_ChIP-Seq_XEN_Mouse1.19000062
74VDR_21846776_ChIP-Seq_THP-1_Human1.17812883
75POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.17593237
76* POU5F1_16153702_ChIP-ChIP_HESCs_Human1.17450704
77* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.16593236
78* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.16454285
79DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.15441408
80* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.13141435
81* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.12978696
82* SOX2_16153702_ChIP-ChIP_HESCs_Human1.11531978
83NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.10402635
84CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.10174260
85FUS_26573619_Chip-Seq_HEK293_Human1.08610425
86IRF1_19129219_ChIP-ChIP_H3396_Human1.07238294
87* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.05824075
88HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.03331189
89TCF3_18692474_ChIP-Seq_MEFs_Mouse1.02809227
90HIF1A_21447827_ChIP-Seq_MCF-7_Human1.02755420
91POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.01345665
92PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.01332068
93PADI4_21655091_ChIP-ChIP_MCF-7_Human1.01226671
94SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.01001235
95ZNF263_19887448_ChIP-Seq_K562_Human1.00523792
96FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.99777303
97CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.98903031
98* POU3F2_20337985_ChIP-ChIP_501MEL_Human0.98758805
99DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.96282722
100SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.96012525
101SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.94800076
102HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.94553551
103NOTCH1_21737748_ChIP-Seq_TLL_Human0.94502861
104YY1_21170310_ChIP-Seq_MESCs_Mouse0.92982139
105RBPJ_22232070_ChIP-Seq_NCS_Mouse0.92780775
106UTX_26944678_Chip-Seq_JUKART_Human0.92416163
107TP63_19390658_ChIP-ChIP_HaCaT_Human0.92406935
108KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.91944581
109KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.91944581
110KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.91944581
111SRF_21415370_ChIP-Seq_HL-1_Mouse0.91743323
112STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.91506160
113SOX2_18555785_ChIP-Seq_MESCs_Mouse0.91357172
114MYB_21317192_ChIP-Seq_ERMYB_Mouse0.90443015
115CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.89798995
116TP63_17297297_ChIP-ChIP_HaCaT_Human0.89359133
117SALL1_21062744_ChIP-ChIP_HESCs_Human0.87166557
118GATA1_22025678_ChIP-Seq_K562_Human0.86766109
119CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.86703693
120FLI1_27457419_Chip-Seq_LIVER_Mouse0.86346517
121SPI1_23547873_ChIP-Seq_NB4_Human0.86104396
122RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.85938801
123CHD1_26751641_Chip-Seq_LNCaP_Human0.85927349
124NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.85742633
125GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.85529064
126BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.85343228
127MAF_26560356_Chip-Seq_TH1_Human0.85010445
128CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.83867922
129NANOG_21062744_ChIP-ChIP_HESCs_Human0.83246245
130MYB_26560356_Chip-Seq_TH2_Human0.83228647
131HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.82819100
132NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.82055494
133MYB_26560356_Chip-Seq_TH1_Human0.81467726
134TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.81095020
135TCF3_18692474_ChIP-Seq_MESCs_Mouse0.78304168
136NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.75657266
137IGF1R_20145208_ChIP-Seq_DFB_Human0.75185559
138RXR_22158963_ChIP-Seq_LIVER_Mouse0.74636777

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005670_abnormal_white_adipose3.51294623
2MP0009697_abnormal_copulation3.30454906
3MP0003693_abnormal_embryo_hatching3.25672157
4MP0010094_abnormal_chromosome_stability3.16610044
5MP0003111_abnormal_nucleus_morphology3.15686465
6MP0004957_abnormal_blastocyst_morpholog2.97348049
7MP0002139_abnormal_hepatobiliary_system2.94380483
8MP0003941_abnormal_skin_development2.86390121
9MP0003077_abnormal_cell_cycle2.84753912
10MP0008057_abnormal_DNA_replication2.72913335
11MP0003718_maternal_effect2.57477009
12MP0010352_gastrointestinal_tract_polyps2.56315455
13MP0005666_abnormal_adipose_tissue2.48855786
14MP0004185_abnormal_adipocyte_glucose2.44519887
15MP0003195_calcinosis2.33852328
16MP0008007_abnormal_cellular_replicative2.25255972
17MP0003705_abnormal_hypodermis_morpholog2.03990454
18MP0001730_embryonic_growth_arrest2.01602374
19MP0008058_abnormal_DNA_repair1.90498773
20MP0002396_abnormal_hematopoietic_system1.86909035
21MP0008438_abnormal_cutaneous_collagen1.83567596
22MP0005085_abnormal_gallbladder_physiolo1.80741833
23MP0005076_abnormal_cell_differentiation1.79825496
24MP0005365_abnormal_bile_salt1.79543292
25MP0005375_adipose_tissue_phenotype1.78579385
26MP0000350_abnormal_cell_proliferation1.75445599
27MP0003123_paternal_imprinting1.70463610
28MP0008932_abnormal_embryonic_tissue1.69920380
29MP0010307_abnormal_tumor_latency1.67845419
30MP0003868_abnormal_feces_composition1.56004563
31MP0001672_abnormal_embryogenesis/_devel1.54032574
32MP0005380_embryogenesis_phenotype1.54032574
33MP0006054_spinal_hemorrhage1.51579305
34MP0003984_embryonic_growth_retardation1.50496142
35MP0002088_abnormal_embryonic_growth/wei1.49173331
36MP0008877_abnormal_DNA_methylation1.46309247
37MP0005397_hematopoietic_system_phenotyp1.46179575
38MP0001545_abnormal_hematopoietic_system1.46179575
39MP0001666_abnormal_nutrient_absorption1.45835901
40MP0003566_abnormal_cell_adhesion1.42165701
41MP0001697_abnormal_embryo_size1.39952850
42MP0004197_abnormal_fetal_growth/weight/1.38071916
43MP0002970_abnormal_white_adipose1.33788403
44MP0002080_prenatal_lethality1.32827847
45MP0004808_abnormal_hematopoietic_stem1.30886888
46MP0005360_urolithiasis1.29818510
47MP0003763_abnormal_thymus_physiology1.29264599
48MP0001764_abnormal_homeostasis1.28362431
49MP0009672_abnormal_birth_weight1.28015929
50MP0005395_other_phenotype1.27445925
51MP0002254_reproductive_system_inflammat1.26900557
52MP0002086_abnormal_extraembryonic_tissu1.26278020
53MP0005332_abnormal_amino_acid1.26099267
54MP0003186_abnormal_redox_activity1.25775179
55MP0002138_abnormal_hepatobiliary_system1.23985711
56MP0004130_abnormal_muscle_cell1.23240940
57MP0003937_abnormal_limbs/digits/tail_de1.22383633
58MP0010329_abnormal_lipoprotein_level1.21998181
59MP0004147_increased_porphyrin_level1.20878590
60MP0006292_abnormal_olfactory_placode1.19603792
61MP0000003_abnormal_adipose_tissue1.18514466
62MP0003786_premature_aging1.18423708
63MP0002084_abnormal_developmental_patter1.18122272
64MP0000490_abnormal_crypts_of1.17088167
65MP0002019_abnormal_tumor_incidence1.15661623
66MP0002085_abnormal_embryonic_tissue1.15123779
67MP0005275_abnormal_skin_tensile1.14517751
68MP0010030_abnormal_orbit_morphology1.14428965
69MP0008875_abnormal_xenobiotic_pharmacok1.12960010
70MP0009115_abnormal_fat_cell1.11659242
71MP0006035_abnormal_mitochondrial_morpho1.10855208
72MP0002697_abnormal_eye_size1.10580664
73MP0003567_abnormal_fetal_cardiomyocyte1.09538377
74MP0010234_abnormal_vibrissa_follicle1.09476144
75MP0003890_abnormal_embryonic-extraembry1.09030844
76MP0009053_abnormal_anal_canal1.08521815
77MP0005023_abnormal_wound_healing1.07672978
78MP0003806_abnormal_nucleotide_metabolis1.05995378
79MP0003252_abnormal_bile_duct1.05786915
80MP0000313_abnormal_cell_death1.05540719
81MP0002166_altered_tumor_susceptibility1.04698983
82MP0002971_abnormal_brown_adipose1.03506442
83MP0000858_altered_metastatic_potential0.99307891
84MP0003656_abnormal_erythrocyte_physiolo0.96253702
85MP0002398_abnormal_bone_marrow0.94610653
86MP0002233_abnormal_nose_morphology0.94128048
87MP0001915_intracranial_hemorrhage0.94049591
88MP0000703_abnormal_thymus_morphology0.93625795
89MP0006036_abnormal_mitochondrial_physio0.92259907
90MP0001286_abnormal_eye_development0.91229319
91MP0001293_anophthalmia0.91051988
92MP0003221_abnormal_cardiomyocyte_apopto0.90117728
93MP0009333_abnormal_splenocyte_physiolog0.90104709
94MP0001849_ear_inflammation0.89318665
95MP0000537_abnormal_urethra_morphology0.88161111
96MP0002722_abnormal_immune_system0.87619452
97MP0003119_abnormal_digestive_system0.86275740
98MP0002210_abnormal_sex_determination0.85644644
99MP0005408_hypopigmentation0.84564915
100MP0005501_abnormal_skin_physiology0.83980822
101MP0002938_white_spotting0.83527182
102MP0000689_abnormal_spleen_morphology0.82916939
103MP0001243_abnormal_dermal_layer0.82477122
104MP0002060_abnormal_skin_morphology0.81280999
105MP0009703_decreased_birth_body0.80427667
106MP0000013_abnormal_adipose_tissue0.80229559
107MP0001661_extended_life_span0.78850179
108MP0002111_abnormal_tail_morphology0.78684733
109MP0000653_abnormal_sex_gland0.77681203
110MP0002006_tumorigenesis0.76924891
111MP0003121_genomic_imprinting0.76123349
112MP0000598_abnormal_liver_morphology0.75568854
113MP0002877_abnormal_melanocyte_morpholog0.75334259
114MP0001853_heart_inflammation0.74781496
115MP0001145_abnormal_male_reproductive0.74161556
116MP0004272_abnormal_basement_membrane0.72328796
117MP0001727_abnormal_embryo_implantation0.71569577
118MP0001929_abnormal_gametogenesis0.71325240
119MP0004264_abnormal_extraembryonic_tissu0.70908159
120MP0002429_abnormal_blood_cell0.70646210
121MP0003699_abnormal_female_reproductive0.70216761
122MP0001119_abnormal_female_reproductive0.70102611
123MP0005334_abnormal_fat_pad0.68019425
124MP0000609_abnormal_liver_physiology0.67653160
125MP0002090_abnormal_vision0.67120978
126MP0000647_abnormal_sebaceous_gland0.66981533
127MP0005379_endocrine/exocrine_gland_phen0.66877123
128MP0003828_pulmonary_edema0.66826152
129MP0001881_abnormal_mammary_gland0.66773675
130MP0008789_abnormal_olfactory_epithelium0.65174016
131MP0003448_altered_tumor_morphology0.64517118
132MP0002092_abnormal_eye_morphology0.63887207
133MP0003950_abnormal_plasma_membrane0.63880630
134MP0002132_abnormal_respiratory_system0.63118058
135MP0005220_abnormal_exocrine_pancreas0.62888448
136MP0003300_gastrointestinal_ulcer0.62189818
137MP0000358_abnormal_cell_content/0.61743490
138MP0002796_impaired_skin_barrier0.60823123
139MP0000477_abnormal_intestine_morphology0.60274833

Predicted human phenotypes

RankGene SetZ-score
1Prolonged partial thromboplastin time (HP:0003645)4.12113408
2Abnormality of methionine metabolism (HP:0010901)3.83523008
3Hypobetalipoproteinemia (HP:0003563)3.69425143
4Birth length less than 3rd percentile (HP:0003561)3.61120400
5Intrahepatic cholestasis (HP:0001406)3.59916875
6Selective tooth agenesis (HP:0001592)3.50465125
7Multiple enchondromatosis (HP:0005701)3.49353205
8Chromosomal breakage induced by crosslinking agents (HP:0003221)3.35968615
9Abnormality of monocarboxylic acid metabolism (HP:0010996)3.35340221
10Abnormality of aspartate family amino acid metabolism (HP:0010899)3.19536181
11Abnormality of the anterior horn cell (HP:0006802)3.07623196
12Degeneration of anterior horn cells (HP:0002398)3.07623196
13Colon cancer (HP:0003003)3.05794988
14Abnormality of aromatic amino acid family metabolism (HP:0004338)3.04062452
15Abnormality of the labia minora (HP:0012880)3.00218994
16Hyperglycinemia (HP:0002154)2.99362098
17Abnormality of serum amino acid levels (HP:0003112)2.98236029
18Abnormality of the heme biosynthetic pathway (HP:0010472)2.93085428
19Hyperglycinuria (HP:0003108)2.85785510
20Abnormality of serine family amino acid metabolism (HP:0010894)2.81527830
21Abnormality of glycine metabolism (HP:0010895)2.81527830
22Ependymoma (HP:0002888)2.80292378
23Complement deficiency (HP:0004431)2.76456836
24Nephroblastoma (Wilms tumor) (HP:0002667)2.74678865
25Reticulocytopenia (HP:0001896)2.69458318
26Abnormality of sulfur amino acid metabolism (HP:0004339)2.68999613
27Pancreatic islet-cell hyperplasia (HP:0004510)2.67536952
28Hypertriglyceridemia (HP:0002155)2.67483683
29Medulloblastoma (HP:0002885)2.66437568
30Abnormal number of erythroid precursors (HP:0012131)2.65132561
31Acanthosis nigricans (HP:0000956)2.65074296
32Short 4th metacarpal (HP:0010044)2.62960392
33Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.62960392
34Abnormality of cells of the erythroid lineage (HP:0012130)2.62923638
35Embryonal renal neoplasm (HP:0011794)2.58449472
36Abnormality of the intrinsic pathway (HP:0010989)2.52392499
37Cutaneous melanoma (HP:0012056)2.51670122
38Basal cell carcinoma (HP:0002671)2.50837971
39Abnormal lung lobation (HP:0002101)2.43707450
40Megaloblastic anemia (HP:0001889)2.41963786
41Oral leukoplakia (HP:0002745)2.41611258
42Hypolipoproteinemia (HP:0010981)2.41455721
43Reduced antithrombin III activity (HP:0001976)2.38456483
44Proximal placement of thumb (HP:0009623)2.35389864
45Deviation of the thumb (HP:0009603)2.33562158
46Abnormality of the preputium (HP:0100587)2.33443497
47High pitched voice (HP:0001620)2.32631968
48Abnormality of pyrimidine metabolism (HP:0004353)2.31801589
49Trismus (HP:0000211)2.29527469
50Aplasia/Hypoplasia of the uvula (HP:0010293)2.29211331
51Conjugated hyperbilirubinemia (HP:0002908)2.26167995
52Rhabdomyolysis (HP:0003201)2.25348888
53Absent radius (HP:0003974)2.24430557
54Glioma (HP:0009733)2.22767350
55Abnormality of the duodenum (HP:0002246)2.20492263
56Aplastic anemia (HP:0001915)2.19807279
57Hypoglycemic coma (HP:0001325)2.19411703
58Abnormality of the 4th metacarpal (HP:0010012)2.18244258
59Breast hypoplasia (HP:0003187)2.11447163
60Microvesicular hepatic steatosis (HP:0001414)2.11347171
61Neoplasm of the pancreas (HP:0002894)2.11059871
62Increased nuchal translucency (HP:0010880)2.10777728
63Nausea (HP:0002018)2.10329347
64Spontaneous abortion (HP:0005268)2.09958622
65Insulin resistance (HP:0000855)2.08920777
66Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.08434702
67Absent thumb (HP:0009777)2.07375262
68Aplasia involving forearm bones (HP:0009822)2.05926721
69Absent forearm bone (HP:0003953)2.05926721
70Reduced subcutaneous adipose tissue (HP:0003758)2.05701668
71Neoplasm of the adrenal gland (HP:0100631)2.05635843
72Clitoromegaly (HP:0000057)2.04098459
7311 pairs of ribs (HP:0000878)2.03247504
74Abnormality of chromosome stability (HP:0003220)2.03138595
75Abnormality of glycolysis (HP:0004366)2.02086117
76Increased serum pyruvate (HP:0003542)2.02086117
77Hypoglycemic seizures (HP:0002173)2.01771150
78Rhabdomyosarcoma (HP:0002859)2.01419053
79Gonadotropin excess (HP:0000837)2.01250088
80Myelodysplasia (HP:0002863)1.98779776
81Abnormality of complement system (HP:0005339)1.98637171
82Atresia of the external auditory canal (HP:0000413)1.97827212
83Increased density of long bones (HP:0006392)1.97767658
84Amaurosis fugax (HP:0100576)1.95644722
85Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.95429989
86Abnormality of alanine metabolism (HP:0010916)1.95429989
87Hyperalaninemia (HP:0003348)1.95429989
88Skin tags (HP:0010609)1.94194771
89Horseshoe kidney (HP:0000085)1.94106089
90Type I transferrin isoform profile (HP:0003642)1.93743892
91Agnosia (HP:0010524)1.93704813
92Adenoma sebaceum (HP:0009720)1.93442795
93Angiofibromas (HP:0010615)1.93442795
94Deep venous thrombosis (HP:0002625)1.92232731
95Oligomenorrhea (HP:0000876)1.91879362
96Missing ribs (HP:0000921)1.91355428
97Patellar aplasia (HP:0006443)1.89596010
98Breast carcinoma (HP:0003002)1.89256039
99Abnormality of reticulocytes (HP:0004312)1.88666632
100Large hands (HP:0001176)1.88143841
101Uterine neoplasm (HP:0010784)1.87959340
102Cerebral edema (HP:0002181)1.87829697
103Neoplasm of the colon (HP:0100273)1.87796495
104Aplasia/Hypoplasia of the patella (HP:0006498)1.87143268
105T lymphocytopenia (HP:0005403)1.85782899
106Prominent nose (HP:0000448)1.84929531
107Squamous cell carcinoma (HP:0002860)1.82513118
108Homocystinuria (HP:0002156)1.82397406
109Abnormality of homocysteine metabolism (HP:0010919)1.82397406
110Pallor (HP:0000980)1.82272128
111Ankle contracture (HP:0006466)1.81353762
112Neoplasm of the small intestine (HP:0100833)1.81049968
113Hypoalphalipoproteinemia (HP:0003233)1.80643418
114Meckel diverticulum (HP:0002245)1.80539058
115Intestinal polyp (HP:0005266)1.80155986
116Cafe-au-lait spot (HP:0000957)1.80046632
117Methylmalonic acidemia (HP:0002912)1.78238983
118Preauricular skin tag (HP:0000384)1.77612483
119Abnormal spermatogenesis (HP:0008669)1.76630126
120Gastrointestinal carcinoma (HP:0002672)1.76564635
121Malignant gastrointestinal tract tumors (HP:0006749)1.76564635
122Combined immunodeficiency (HP:0005387)1.76501609
123Broad palm (HP:0001169)1.76000850
124Hyperammonemia (HP:0001987)1.75884591
125Cellular immunodeficiency (HP:0005374)1.74849177
126Ovarian neoplasm (HP:0100615)1.74723976
127Neoplasm of the liver (HP:0002896)1.74280129
128Neoplasm of striated muscle (HP:0009728)1.73845845
129Abnormality of the common coagulation pathway (HP:0010990)1.73017730
130Abnormality of T cell number (HP:0011839)1.72654616
131Abnormality of subcutaneous fat tissue (HP:0001001)1.72642244
132Hepatocellular carcinoma (HP:0001402)1.72349001
133Acute myeloid leukemia (HP:0004808)1.72211863
134Triphalangeal thumb (HP:0001199)1.71954838
135Hyperinsulinemic hypoglycemia (HP:0000825)1.71079479
136Microretrognathia (HP:0000308)1.71043696
137Neoplasm of the rectum (HP:0100743)1.70793192
138Abnormal number of incisors (HP:0011064)1.70525116
139Thrombocytosis (HP:0001894)1.70419612
140Abnormality of the ileum (HP:0001549)1.70252727
141Rough bone trabeculation (HP:0100670)1.69935925
142Chromsome breakage (HP:0040012)1.68921200
143Rectal prolapse (HP:0002035)1.68360746
144Gout (HP:0001997)1.68046398
145Neoplasm of the oral cavity (HP:0100649)1.67692122
146Hepatoblastoma (HP:0002884)1.67500100
147Macrocytic anemia (HP:0001972)1.67347110
148Ectopic kidney (HP:0000086)1.67156626
149Intestinal polyposis (HP:0200008)1.67024500
150Long eyelashes (HP:0000527)1.66849547
151Protrusio acetabuli (HP:0003179)1.66407218
152Abnormality of T cells (HP:0002843)1.65955195
153Choanal atresia (HP:0000453)1.65750715
154Cortical dysplasia (HP:0002539)1.65590130
155Secondary amenorrhea (HP:0000869)1.65092695
156Astrocytoma (HP:0009592)1.65015842
157Abnormality of the astrocytes (HP:0100707)1.65015842
158Abnormal cartilage morphology (HP:0002763)1.64399345
159Sloping forehead (HP:0000340)1.64194048
160Abnormality of endocrine pancreas physiology (HP:0012093)1.64041262
161Abnormality of the pancreatic islet cells (HP:0006476)1.64041262
162Spastic diplegia (HP:0001264)1.63801955
163Duodenal stenosis (HP:0100867)1.63579577
164Small intestinal stenosis (HP:0012848)1.63579577
165Abnormality of the calcaneus (HP:0008364)1.62575424
166Carpal bone hypoplasia (HP:0001498)1.62318250
167Abnormal biliary tract physiology (HP:0012439)1.62042749
168Volvulus (HP:0002580)1.61300478
169Poikilocytosis (HP:0004447)1.60770005
170Premature graying of hair (HP:0002216)1.60079310
171Biliary tract neoplasm (HP:0100574)1.59422419
172Syringomyelia (HP:0003396)1.58935097
173Spinal cord lesions (HP:0100561)1.58935097

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC73.75282066
2BUB13.17095352
3EIF2AK12.78034614
4TRIM282.72305067
5PBK2.62078796
6WEE12.61220978
7TRIB32.51381701
8NEK22.35856350
9ACVR1B2.28238767
10CDK122.12714322
11MST42.06665027
12WNK31.98455342
13BRD41.98165017
14EEF2K1.93183832
15TESK11.87031437
16TESK21.83035216
17STK101.80429999
18PASK1.78066530
19VRK21.76532479
20TTK1.75801147
21BRSK21.73637236
22RPS6KA41.70591305
23TSSK61.70309327
24TGFBR11.69679891
25CAMK1D1.64883000
26MAP3K101.57925719
27PDK41.54878136
28PDK31.54878136
29NUAK11.54350131
30SRPK11.54098445
31SCYL21.53707699
32TNIK1.51867466
33ATR1.49632009
34TAF11.47243847
35NEK11.46179119
36PLK11.44875694
37BCKDK1.43468047
38CDK41.42641455
39PKN21.42420404
40CDK61.42181992
41NME21.42106162
42CDK71.36828143
43MAP4K11.36578909
44MAP3K81.35783832
45AURKB1.32382762
46DYRK31.32306509
47KDR1.30551905
48STK161.29646009
49MKNK11.23994263
50PLK41.17897110
51RPS6KB21.16864205
52TLK11.13130652
53STK241.12013132
54SIK11.11335445
55STK38L1.10710569
56PAK41.10616644
57NEK91.10577552
58PNCK1.10121379
59FLT31.09951184
60CHEK11.07830053
61MAP2K31.05928493
62ERN11.03882991
63STK41.01971211
64JAK30.97802541
65BCR0.97793935
66ZAP700.97523363
67LRRK20.96158381
68PLK30.93346054
69FGFR10.92951796
70STK30.92146449
71EIF2AK30.91872866
72CHEK20.90496606
73CDK90.89550575
74MTOR0.88214500
75ERBB40.87946044
76BRSK10.86895415
77CLK10.86694478
78ATM0.82448346
79PIM10.80630232
80NLK0.79686974
81ALK0.79359324
82MAP3K120.76987085
83ERBB30.72882299
84PDK20.71136428
85AURKA0.69558950
86PAK20.68442510
87CAMK1G0.68107607
88MELK0.67851407
89CDK20.67343359
90MAP3K110.66741980
91TIE10.66165120
92STK390.65537760
93BMPR1B0.64691790
94LATS10.64654784
95CSNK1G10.62992790
96FGFR20.61516849
97VRK10.59701417
98MAP3K30.58485740
99CSNK1E0.52907965
100MET0.52592313
101YES10.52141824
102PDGFRA0.51078504
103PAK10.50183115
104CSNK2A20.50020205
105OXSR10.49479018
106FGFR30.49205383
107CDK10.48984220
108MKNK20.48723875
109ZAK0.45947336
110CSNK2A10.45213654
111TTN0.42586992
112LIMK10.41315322
113BRAF0.40747197
114MAPKAPK30.40664509
115EIF2AK20.40319806
116TYK20.39009934
117TXK0.37970850
118MAPK110.37586937
119RPS6KA50.37296026
120ITK0.36209744
121LATS20.35937092
122ILK0.35680167
123NME10.35173036
124CHUK0.34188619
125TEC0.33398449
126CCNB10.33108237
127PRKDC0.32820058
128TGFBR20.32816727
129RPS6KB10.31986286
130AKT20.31182164
131FRK0.31001655
132CDK30.30879240
133FGFR40.29756846
134CDK80.28511287
135GRK10.27641457
136CSNK1A1L0.27477769
137PLK20.26898371
138CSNK1G30.25852129
139SMG10.25036539

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.24863156
2Mismatch repair_Homo sapiens_hsa034303.30537880
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.90587732
4RNA transport_Homo sapiens_hsa030132.79028156
5One carbon pool by folate_Homo sapiens_hsa006702.77530025
6Spliceosome_Homo sapiens_hsa030402.76931117
7Base excision repair_Homo sapiens_hsa034102.65633538
8Cell cycle_Homo sapiens_hsa041102.56698626
9Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.42034294
10Nucleotide excision repair_Homo sapiens_hsa034202.26444711
11Homologous recombination_Homo sapiens_hsa034402.23670489
12Proteasome_Homo sapiens_hsa030502.22185400
13Ribosome_Homo sapiens_hsa030102.07631016
14Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.01533155
15Pentose and glucuronate interconversions_Homo sapiens_hsa000401.75947822
16RNA polymerase_Homo sapiens_hsa030201.75441542
17Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.74968193
18Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.74599381
19Pyrimidine metabolism_Homo sapiens_hsa002401.69185633
20Non-homologous end-joining_Homo sapiens_hsa034501.68799010
21Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.66461405
22Fatty acid elongation_Homo sapiens_hsa000621.66041044
23p53 signaling pathway_Homo sapiens_hsa041151.57969693
24Arginine biosynthesis_Homo sapiens_hsa002201.57666818
25Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.50368112
26Retinol metabolism_Homo sapiens_hsa008301.50290347
27* mRNA surveillance pathway_Homo sapiens_hsa030151.50198434
28Primary bile acid biosynthesis_Homo sapiens_hsa001201.48815976
29Fanconi anemia pathway_Homo sapiens_hsa034601.47456954
30Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.46054416
31RNA degradation_Homo sapiens_hsa030181.45060511
32Protein export_Homo sapiens_hsa030601.44038955
33Selenocompound metabolism_Homo sapiens_hsa004501.41075735
34Complement and coagulation cascades_Homo sapiens_hsa046101.37074092
35Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.36676394
36Propanoate metabolism_Homo sapiens_hsa006401.33285781
37Basal transcription factors_Homo sapiens_hsa030221.31207126
38Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.28835954
39Butanoate metabolism_Homo sapiens_hsa006501.28395682
40Carbon metabolism_Homo sapiens_hsa012001.27328391
41Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.25682354
422-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.20334044
43Steroid biosynthesis_Homo sapiens_hsa001001.18034695
44Phenylalanine metabolism_Homo sapiens_hsa003601.16953481
45Fatty acid biosynthesis_Homo sapiens_hsa000611.16524939
46Biosynthesis of amino acids_Homo sapiens_hsa012301.16400193
47Pentose phosphate pathway_Homo sapiens_hsa000301.15614402
48Viral carcinogenesis_Homo sapiens_hsa052031.12128393
49Antigen processing and presentation_Homo sapiens_hsa046121.11659743
50Sulfur metabolism_Homo sapiens_hsa009201.10734243
51Pyruvate metabolism_Homo sapiens_hsa006201.09693869
52Herpes simplex infection_Homo sapiens_hsa051681.09516287
53Systemic lupus erythematosus_Homo sapiens_hsa053221.08225841
54Epstein-Barr virus infection_Homo sapiens_hsa051691.06708287
55Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.03498895
56Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.01649687
57Histidine metabolism_Homo sapiens_hsa003401.00285689
58Tyrosine metabolism_Homo sapiens_hsa003501.00183971
59Thyroid cancer_Homo sapiens_hsa052161.00045410
60HTLV-I infection_Homo sapiens_hsa051660.98835623
61PPAR signaling pathway_Homo sapiens_hsa033200.98736983
62Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.98659684
63Tryptophan metabolism_Homo sapiens_hsa003800.98614951
64Small cell lung cancer_Homo sapiens_hsa052220.98469971
65Chemical carcinogenesis_Homo sapiens_hsa052040.97527315
66Legionellosis_Homo sapiens_hsa051340.97292449
67Steroid hormone biosynthesis_Homo sapiens_hsa001400.91251710
68Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.91093258
69Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.89877394
70Cysteine and methionine metabolism_Homo sapiens_hsa002700.89233088
71beta-Alanine metabolism_Homo sapiens_hsa004100.88803935
72Peroxisome_Homo sapiens_hsa041460.85068251
73Caffeine metabolism_Homo sapiens_hsa002320.84021238
74Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.81428620
75Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.80196621
76Arginine and proline metabolism_Homo sapiens_hsa003300.79370631
77Vitamin B6 metabolism_Homo sapiens_hsa007500.78023058
78Central carbon metabolism in cancer_Homo sapiens_hsa052300.77677691
79Starch and sucrose metabolism_Homo sapiens_hsa005000.77020849
80Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.76796253
81MicroRNAs in cancer_Homo sapiens_hsa052060.74233152
82Viral myocarditis_Homo sapiens_hsa054160.73072967
83Vitamin digestion and absorption_Homo sapiens_hsa049770.72513122
84Fatty acid metabolism_Homo sapiens_hsa012120.72268550
85Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.69321223
86* AMPK signaling pathway_Homo sapiens_hsa041520.68382579
87Glycerolipid metabolism_Homo sapiens_hsa005610.68227272
88Chronic myeloid leukemia_Homo sapiens_hsa052200.68084872
89Purine metabolism_Homo sapiens_hsa002300.67309149
90Acute myeloid leukemia_Homo sapiens_hsa052210.65952244
91Fatty acid degradation_Homo sapiens_hsa000710.64820886
92Lysine degradation_Homo sapiens_hsa003100.63717995
93Measles_Homo sapiens_hsa051620.63269600
94Drug metabolism - other enzymes_Homo sapiens_hsa009830.63194978
95Sulfur relay system_Homo sapiens_hsa041220.63008149
96* Oocyte meiosis_Homo sapiens_hsa041140.62445532
97Metabolic pathways_Homo sapiens_hsa011000.61277240
98Adipocytokine signaling pathway_Homo sapiens_hsa049200.59850584
99Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.59509187
100Primary immunodeficiency_Homo sapiens_hsa053400.56512492
101Glutathione metabolism_Homo sapiens_hsa004800.55295232
102Apoptosis_Homo sapiens_hsa042100.55159448
103Transcriptional misregulation in cancer_Homo sapiens_hsa052020.54779665
104Cyanoamino acid metabolism_Homo sapiens_hsa004600.54565341
105Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.53792306
106Basal cell carcinoma_Homo sapiens_hsa052170.51717351
107HIF-1 signaling pathway_Homo sapiens_hsa040660.51216474
108NF-kappa B signaling pathway_Homo sapiens_hsa040640.50846083
109Maturity onset diabetes of the young_Homo sapiens_hsa049500.50264419
110Hepatitis B_Homo sapiens_hsa051610.48911848
111Adherens junction_Homo sapiens_hsa045200.47019183
112Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.45306568
113Fat digestion and absorption_Homo sapiens_hsa049750.43740709
114Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.43614622
115Folate biosynthesis_Homo sapiens_hsa007900.42299418
116* TGF-beta signaling pathway_Homo sapiens_hsa043500.42252465
117Bladder cancer_Homo sapiens_hsa052190.41717358
118N-Glycan biosynthesis_Homo sapiens_hsa005100.41560684
119Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.41101436
120Insulin resistance_Homo sapiens_hsa049310.40237757
121* Hippo signaling pathway_Homo sapiens_hsa043900.39861492
122Renin-angiotensin system_Homo sapiens_hsa046140.39566938
123Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.38576834
124Colorectal cancer_Homo sapiens_hsa052100.37146439
125Notch signaling pathway_Homo sapiens_hsa043300.36038954
126mTOR signaling pathway_Homo sapiens_hsa041500.35672860
127Linoleic acid metabolism_Homo sapiens_hsa005910.34971306
128Proteoglycans in cancer_Homo sapiens_hsa052050.33213469
129Shigellosis_Homo sapiens_hsa051310.32427523
130Insulin signaling pathway_Homo sapiens_hsa049100.31654613
131Pancreatic cancer_Homo sapiens_hsa052120.30386781
132Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.30307788
133Hematopoietic cell lineage_Homo sapiens_hsa046400.29411671
134Toxoplasmosis_Homo sapiens_hsa051450.29339752
135Galactose metabolism_Homo sapiens_hsa000520.28473031
136Bile secretion_Homo sapiens_hsa049760.22617645
137Huntingtons disease_Homo sapiens_hsa050160.21270493
138Parkinsons disease_Homo sapiens_hsa050120.18827672
139Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.16230514

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