PPP2R2A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The product of this gene belongs to the phosphatase 2 regulatory subunit B family. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes an alpha isoform of the regulatory subunit B55 subfamily. Alternatively spliced transcript variants have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)5.35180754
2mitotic sister chromatid cohesion (GO:0007064)5.28201865
3nuclear pore organization (GO:0006999)5.07281551
4axon ensheathment in central nervous system (GO:0032291)4.96178960
5central nervous system myelination (GO:0022010)4.96178960
6protein localization to kinetochore (GO:0034501)4.70098070
7mitotic chromosome condensation (GO:0007076)4.69358692
8protein localization to chromosome, centromeric region (GO:0071459)4.53909619
9mitotic sister chromatid segregation (GO:0000070)3.88679396
10sister chromatid segregation (GO:0000819)3.83984653
11DNA replication checkpoint (GO:0000076)3.81905608
12IMP biosynthetic process (GO:0006188)3.81108278
13long-chain fatty acid biosynthetic process (GO:0042759)3.79219086
14pore complex assembly (GO:0046931)3.76189592
15heterochromatin organization (GO:0070828)3.63517606
16IMP metabolic process (GO:0046040)3.59331900
17myelination (GO:0042552)3.50292270
18attachment of spindle microtubules to kinetochore (GO:0008608)3.49297811
19axon ensheathment (GO:0008366)3.48995705
20ensheathment of neurons (GO:0007272)3.48995705
21regulation of helicase activity (GO:0051095)3.48033110
22formation of translation preinitiation complex (GO:0001731)3.46325899
23folic acid-containing compound biosynthetic process (GO:0009396)3.36152657
24rRNA transcription (GO:0009303)3.35609895
25pre-miRNA processing (GO:0031054)3.34081138
26negative regulation of neurotransmitter secretion (GO:0046929)3.20907473
27regulation of DNA endoreduplication (GO:0032875)3.19966930
28maturation of SSU-rRNA (GO:0030490)3.14943878
29regulation of centriole replication (GO:0046599)3.13344342
30histone exchange (GO:0043486)3.13074163
31mitotic nuclear envelope disassembly (GO:0007077)3.12012805
32purine nucleobase biosynthetic process (GO:0009113)3.11808812
33ribosomal large subunit biogenesis (GO:0042273)3.11506447
34transcription from mitochondrial promoter (GO:0006390)3.10985634
35positive regulation of mitotic sister chromatid separation (GO:1901970)3.10365630
36positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.10365630
37positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.10365630
38positive regulation of histone H3-K4 methylation (GO:0051571)3.08981455
39ribosomal small subunit biogenesis (GO:0042274)3.06589054
40DNA replication-independent nucleosome assembly (GO:0006336)3.05938159
41DNA replication-independent nucleosome organization (GO:0034724)3.05938159
42membrane disassembly (GO:0030397)3.01970163
43nuclear envelope disassembly (GO:0051081)3.01970163
44negative regulation of neurotransmitter transport (GO:0051589)3.00962902
45regulation of chromosome segregation (GO:0051983)3.00343573
46negative regulation of DNA repair (GO:0045738)2.96809127
47regulation of mitotic metaphase/anaphase transition (GO:0030071)2.95029388
48regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.95029388
49negative regulation of chromosome segregation (GO:0051985)2.91659050
50sister chromatid cohesion (GO:0007062)2.90937503
51negative regulation of mitotic sister chromatid separation (GO:2000816)2.89893202
52negative regulation of sister chromatid segregation (GO:0033046)2.89893202
53negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.89893202
54negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.89893202
55negative regulation of mitotic sister chromatid segregation (GO:0033048)2.89893202
56regulation of centrosome cycle (GO:0046605)2.86460833
57regulation of mitotic sister chromatid separation (GO:0010965)2.86361989
58regulation of mitotic sister chromatid segregation (GO:0033047)2.86361989
59regulation of sister chromatid segregation (GO:0033045)2.86361989
60cytoplasmic mRNA processing body assembly (GO:0033962)2.83531634
61regulation of DNA methylation (GO:0044030)2.82723042
62negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.81968418
63protein localization to chromosome (GO:0034502)2.81784629
64regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.79732027
65ribonucleoprotein complex biogenesis (GO:0022613)2.79441603
66presynaptic membrane assembly (GO:0097105)2.78266355
67regulation of translational fidelity (GO:0006450)2.78264858
68negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.77949122
69DNA strand elongation (GO:0022616)2.76108172
70nucleobase biosynthetic process (GO:0046112)2.71174066
71negative regulation of mRNA metabolic process (GO:1903312)2.70200770
72negative regulation of mRNA processing (GO:0050686)2.70067082
73lateral sprouting from an epithelium (GO:0060601)2.69841302
74double-strand break repair via nonhomologous end joining (GO:0006303)2.69630788
75non-recombinational repair (GO:0000726)2.69630788
76chromosome segregation (GO:0007059)2.69303505
77negative regulation of RNA splicing (GO:0033119)2.67940107
78spindle assembly checkpoint (GO:0071173)2.67721350
79mitotic spindle assembly checkpoint (GO:0007094)2.67081869
80chromosome condensation (GO:0030261)2.67013652
81ribosome biogenesis (GO:0042254)2.66625302
82NLS-bearing protein import into nucleus (GO:0006607)2.66047506
83translational initiation (GO:0006413)2.65407928
84ER overload response (GO:0006983)2.65342535
85positive regulation of cell cycle checkpoint (GO:1901978)2.64897201
86neuron cell-cell adhesion (GO:0007158)2.62914151
87telomere maintenance via semi-conservative replication (GO:0032201)2.62568346
88kinetochore assembly (GO:0051382)2.60346531
89response to X-ray (GO:0010165)2.59971604
90fatty acid elongation (GO:0030497)2.59344527
91translational termination (GO:0006415)2.57396504
92presynaptic membrane organization (GO:0097090)2.54773620
93negative regulation of myoblast differentiation (GO:0045662)2.52818472
94establishment of mitochondrion localization (GO:0051654)2.49463190
95* mitotic nuclear envelope reassembly (GO:0007084)2.48919213
96* nuclear envelope reassembly (GO:0031468)2.48919213
97regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.43266709
98cellular protein complex localization (GO:0034629)2.42302170
99DNA unwinding involved in DNA replication (GO:0006268)2.42118252
100positive regulation of oligodendrocyte differentiation (GO:0048714)2.39294852
101regulation of collateral sprouting (GO:0048670)2.34990483
102regulation of exit from mitosis (GO:0007096)2.34742746
103histone H2B ubiquitination (GO:0033523)2.31964395
104negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)2.31068180
105establishment of integrated proviral latency (GO:0075713)2.26170832
106Rap protein signal transduction (GO:0032486)2.25557301
107transcription elongation from RNA polymerase III promoter (GO:0006385)2.23122666
108termination of RNA polymerase III transcription (GO:0006386)2.23122666
109positive regulation of actin filament depolymerization (GO:0030836)2.22581149
110mitotic metaphase plate congression (GO:0007080)2.21010780
111protein neddylation (GO:0045116)2.19878302
112DNA replication initiation (GO:0006270)2.19084136
113cerebral cortex radially oriented cell migration (GO:0021799)2.14650724
114alternative mRNA splicing, via spliceosome (GO:0000380)2.14511293
115cullin deneddylation (GO:0010388)2.13545074
116positive regulation of chromosome segregation (GO:0051984)2.13368493
117substantia nigra development (GO:0021762)2.12218425
118astrocyte development (GO:0014002)2.10316346
119DNA ligation (GO:0006266)2.09983378
120myelination in peripheral nervous system (GO:0022011)2.08009242
121peripheral nervous system axon ensheathment (GO:0032292)2.08009242
122regulation of spindle organization (GO:0090224)2.06877765
123positive regulation of transcription elongation from RNA polymerase II promoter (GO:0032968)2.06467581
1247-methylguanosine RNA capping (GO:0009452)2.06297042
125RNA capping (GO:0036260)2.06297042
126myelin maintenance (GO:0043217)2.06047654
127establishment of viral latency (GO:0019043)2.05685786
128metaphase plate congression (GO:0051310)2.04351775
129establishment of protein localization to mitochondrial membrane (GO:0090151)2.02434899
130viral mRNA export from host cell nucleus (GO:0046784)2.02167105
1317-methylguanosine mRNA capping (GO:0006370)2.00336453
132asymmetric protein localization (GO:0008105)2.00164579
133protein complex localization (GO:0031503)1.96556273
134L-methionine biosynthetic process from methylthioadenosine (GO:0019509)1.96336379
135CENP-A containing nucleosome assembly (GO:0034080)1.96070154
136microtubule polymerization or depolymerization (GO:0031109)1.95574885
137negative regulation of protein localization to cell surface (GO:2000009)1.94124628
138regulation of mitotic spindle organization (GO:0060236)1.92993320
139kinetochore organization (GO:0051383)1.91226331
140transcription elongation from RNA polymerase I promoter (GO:0006362)1.91078357
141proteasome assembly (GO:0043248)1.90946639
142regulation of RNA export from nucleus (GO:0046831)1.90906922
143oligodendrocyte differentiation (GO:0048709)1.89885160
144negative regulation by host of viral transcription (GO:0043922)1.88446255
145dermatan sulfate metabolic process (GO:0030205)1.87771641
146establishment of chromosome localization (GO:0051303)1.87263700
147chromatin remodeling at centromere (GO:0031055)1.86983541
148regulation of neuron projection regeneration (GO:0070570)1.85816474
149regulation of axon regeneration (GO:0048679)1.85816474
150negative regulation of JAK-STAT cascade (GO:0046426)1.82914002
151dermatan sulfate biosynthetic process (GO:0030208)1.81968948
152nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)1.81870011
153postsynaptic membrane organization (GO:0001941)1.80536897
154regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)1.79975409
155regulation of mitotic spindle checkpoint (GO:1903504)1.79975409
156regulation of myelination (GO:0031641)1.79963788
157positive regulation of DNA-templated transcription, elongation (GO:0032786)1.79896703
158RNA splicing, via transesterification reactions (GO:0000375)1.79525438
159apical protein localization (GO:0045176)1.79518884
160termination of RNA polymerase I transcription (GO:0006363)1.79363217
161ribosome assembly (GO:0042255)1.79272375
162mitotic cytokinesis (GO:0000281)1.78716474
163spliceosomal snRNP assembly (GO:0000387)1.78652516
164spindle checkpoint (GO:0031577)1.77951674
165negative regulation of axonogenesis (GO:0050771)1.77391928
166preassembly of GPI anchor in ER membrane (GO:0016254)1.77350955
167mRNA polyadenylation (GO:0006378)1.77304191
168DNA strand elongation involved in DNA replication (GO:0006271)1.76757285
169transmission of nerve impulse (GO:0019226)1.76670226
170RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)1.76362632
171mRNA splicing, via spliceosome (GO:0000398)1.76362632
172transcription-coupled nucleotide-excision repair (GO:0006283)1.76293852
173pseudouridine synthesis (GO:0001522)1.75636455
174mitotic spindle checkpoint (GO:0071174)1.75611591
175dendritic spine morphogenesis (GO:0060997)1.74764007
176RNA polyadenylation (GO:0043631)1.74430332
177protein deneddylation (GO:0000338)1.74130883
178DNA topological change (GO:0006265)1.73767104

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.88165575
2HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.63497173
3* MYC_18555785_ChIP-Seq_MESCs_Mouse2.66315196
4PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.31576277
5* E2F1_21310950_ChIP-Seq_MCF-7_Human2.28399257
6E2F4_17652178_ChIP-ChIP_JURKAT_Human2.26551062
7CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.19776061
8SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.06794228
9KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.01161280
10* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.00569916
11FOXM1_23109430_ChIP-Seq_U2OS_Human1.97529902
12EST1_17652178_ChIP-ChIP_JURKAT_Human1.96347926
13MYC_19079543_ChIP-ChIP_MESCs_Mouse1.92680174
14* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.89672721
15E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.83983095
16ZFX_18555785_ChIP-Seq_MESCs_Mouse1.82981405
17* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.82339212
18KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.80378260
19KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.80378260
20KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.80378260
21* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.80327210
22* CHD1_26751641_Chip-Seq_LNCaP_Human1.78482477
23PADI4_21655091_ChIP-ChIP_MCF-7_Human1.74642430
24CREB1_15753290_ChIP-ChIP_HEK293T_Human1.73535908
25SALL1_21062744_ChIP-ChIP_HESCs_Human1.69817225
26ELK1_19687146_ChIP-ChIP_HELA_Human1.69551149
27* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.69397370
28GABP_17652178_ChIP-ChIP_JURKAT_Human1.68553934
29FUS_26573619_Chip-Seq_HEK293_Human1.67676162
30FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.66210346
31* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.63645415
32EWS_26573619_Chip-Seq_HEK293_Human1.62664284
33SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.61952894
34ETS1_20019798_ChIP-Seq_JURKAT_Human1.59394155
35AR_21572438_ChIP-Seq_LNCaP_Human1.58984396
36POU5F1_16153702_ChIP-ChIP_HESCs_Human1.55446764
37GBX2_23144817_ChIP-Seq_PC3_Human1.54169968
38RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.52508701
39HOXB4_20404135_ChIP-ChIP_EML_Mouse1.52250234
40FOXP3_21729870_ChIP-Seq_TREG_Human1.50327743
41MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.49750042
42FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.48519917
43NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.45068473
44HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.40539018
45NELFA_20434984_ChIP-Seq_ESCs_Mouse1.39334527
46* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.37103091
47WT1_19549856_ChIP-ChIP_CCG9911_Human1.36554929
48THAP11_20581084_ChIP-Seq_MESCs_Mouse1.35436852
49KDM5A_27292631_Chip-Seq_BREAST_Human1.35106941
50XRN2_22483619_ChIP-Seq_HELA_Human1.34504180
51TAF15_26573619_Chip-Seq_HEK293_Human1.34481878
52HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.34200053
53TTF2_22483619_ChIP-Seq_HELA_Human1.33464458
54MYC_18358816_ChIP-ChIP_MESCs_Mouse1.33240918
55VDR_23849224_ChIP-Seq_CD4+_Human1.30782750
56TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.30317472
57CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.29578111
58* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.28664515
59ERG_20887958_ChIP-Seq_HPC-7_Mouse1.26655622
60AR_21909140_ChIP-Seq_LNCAP_Human1.25978888
61E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.25726950
62MYCN_18555785_ChIP-Seq_MESCs_Mouse1.25448195
63DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.24422970
64SOX17_20123909_ChIP-Seq_XEN_Mouse1.22578469
65ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.21953866
66EGR1_19374776_ChIP-ChIP_THP-1_Human1.21729834
67NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.21657467
68JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.20567491
69TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.17906337
70SOX2_16153702_ChIP-ChIP_HESCs_Human1.17292843
71FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.16911971
72YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.16229324
73CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.14485220
74KLF4_18555785_ChIP-Seq_MESCs_Mouse1.12852938
75GABP_19822575_ChIP-Seq_HepG2_Human1.11916750
76NANOG_16153702_ChIP-ChIP_HESCs_Human1.11622171
77ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.10545953
78NOTCH1_21737748_ChIP-Seq_TLL_Human1.08901384
79STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.08863914
80MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.08849706
81FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.06925052
82TFEB_21752829_ChIP-Seq_HELA_Human1.05064623
83FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.01259626
84NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.00618000
85EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.00471014
86SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.99670344
87POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.98739438
88ER_23166858_ChIP-Seq_MCF-7_Human0.98726439
89VDR_22108803_ChIP-Seq_LS180_Human0.98161751
90* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.98069031
91SMAD_19615063_ChIP-ChIP_OVARY_Human0.97386557
92ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.96575484
93TCF3_18692474_ChIP-Seq_MEFs_Mouse0.96246975
94SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.95916265
95RNF2_27304074_Chip-Seq_NSC_Mouse0.95242995
96SOX2_18555785_ChIP-Seq_MESCs_Mouse0.94907072
97GATA1_26923725_Chip-Seq_HPCs_Mouse0.92588649
98KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.92071727
99ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.91520567
100VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.91473351
101SALL4_18804426_ChIP-ChIP_XEN_Mouse0.91124993
102* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.90211968
103POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.90009495
104MYC_18940864_ChIP-ChIP_HL60_Human0.89464184
105NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.88367502
106TP63_19390658_ChIP-ChIP_HaCaT_Human0.87720090
107PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.87690856
108EZH2_27304074_Chip-Seq_ESCs_Mouse0.87684230
109ZFP57_27257070_Chip-Seq_ESCs_Mouse0.87523901
110* SOX9_26525672_Chip-Seq_HEART_Mouse0.87497931
111RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.86843795
112* E2F1_18555785_ChIP-Seq_MESCs_Mouse0.86358408
113WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.85713226
114CBX2_27304074_Chip-Seq_ESCs_Mouse0.85546378
115NANOG_18555785_ChIP-Seq_MESCs_Mouse0.85335027
116SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.84890994
117DCP1A_22483619_ChIP-Seq_HELA_Human0.84532029
118LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.84350124
119POU3F2_20337985_ChIP-ChIP_501MEL_Human0.84071581
120JARID2_20064375_ChIP-Seq_MESCs_Mouse0.83966276
121GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.83653755
122TCF3_18692474_ChIP-Seq_MESCs_Mouse0.82543901
123EOMES_21245162_ChIP-Seq_HESCs_Human0.82349759
124YY1_21170310_ChIP-Seq_MESCs_Mouse0.81826213
125POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.81576553
126CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.80772510
127NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.80424763
128IRF1_19129219_ChIP-ChIP_H3396_Human0.80223316
129SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.79373282
130SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.79373282
131FLI1_27457419_Chip-Seq_LIVER_Mouse0.79015374
132TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.79009569
133NANOG_21062744_ChIP-ChIP_HESCs_Human0.78725884
134KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.77572799
135SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.77153791
136ELF5_23300383_ChIP-Seq_T47D_Human0.76407188
137TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.75704633
138HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.75451141
139RBPJ_22232070_ChIP-Seq_NCS_Mouse0.74953295
140ELK1_22589737_ChIP-Seq_MCF10A_Human0.74805384

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010352_gastrointestinal_tract_polyps3.27453747
2MP0003880_abnormal_central_pattern3.15323888
3MP0003890_abnormal_embryonic-extraembry3.14296239
4MP0008057_abnormal_DNA_replication3.02295650
5MP0010234_abnormal_vibrissa_follicle2.72647957
6MP0000920_abnormal_myelination2.54397639
7MP0002796_impaired_skin_barrier2.24725235
8MP0009697_abnormal_copulation2.17366454
9MP0001529_abnormal_vocalization2.13801843
10MP0005409_darkened_coat_color1.98712488
11MP0008932_abnormal_embryonic_tissue1.92042298
12MP0005171_absent_coat_pigmentation1.87998026
13MP0004185_abnormal_adipocyte_glucose1.81598907
14MP0010307_abnormal_tumor_latency1.75112160
15MP0003221_abnormal_cardiomyocyte_apopto1.73205202
16MP0004957_abnormal_blastocyst_morpholog1.71054320
17MP0010094_abnormal_chromosome_stability1.70824953
18MP0003718_maternal_effect1.69813158
19MP0002009_preneoplasia1.67241599
20MP0004270_analgesia1.67010874
21MP0008877_abnormal_DNA_methylation1.65537080
22MP0003941_abnormal_skin_development1.63578035
23MP0004742_abnormal_vestibular_system1.63555550
24MP0000579_abnormal_nail_morphology1.62893131
25MP0005501_abnormal_skin_physiology1.60171780
26MP0008007_abnormal_cellular_replicative1.58613364
27MP0003136_yellow_coat_color1.57119133
28MP0009672_abnormal_birth_weight1.56869410
29MP0000537_abnormal_urethra_morphology1.53531847
30MP0003077_abnormal_cell_cycle1.49010611
31MP0000778_abnormal_nervous_system1.46068259
32MP0010030_abnormal_orbit_morphology1.40557208
33MP0003937_abnormal_limbs/digits/tail_de1.39189898
34MP0001188_hyperpigmentation1.38635176
35MP0003123_paternal_imprinting1.37058875
36MP0004859_abnormal_synaptic_plasticity1.34755398
37MP0005503_abnormal_tendon_morphology1.34526625
38MP0005666_abnormal_adipose_tissue1.34332833
39MP0001905_abnormal_dopamine_level1.34104294
40MP0002080_prenatal_lethality1.33159628
41MP0003950_abnormal_plasma_membrane1.32883537
42MP0005623_abnormal_meninges_morphology1.31218077
43MP0009250_abnormal_appendicular_skeleto1.30863470
44MP0003111_abnormal_nucleus_morphology1.30574668
45MP0001485_abnormal_pinna_reflex1.29634549
46MP0005423_abnormal_somatic_nervous1.26274087
47MP0002086_abnormal_extraembryonic_tissu1.25962860
48MP0001486_abnormal_startle_reflex1.23242906
49MP0009379_abnormal_foot_pigmentation1.23166642
50MP0003938_abnormal_ear_development1.22740040
51MP0006292_abnormal_olfactory_placode1.20481269
52MP0004233_abnormal_muscle_weight1.18630067
53MP0001730_embryonic_growth_arrest1.18078959
54MP0000313_abnormal_cell_death1.17954121
55MP0008058_abnormal_DNA_repair1.16956639
56MP0003121_genomic_imprinting1.12678585
57MP0001299_abnormal_eye_distance/1.12329947
58MP0003693_abnormal_embryo_hatching1.10109255
59MP0000350_abnormal_cell_proliferation1.09902081
60MP0001216_abnormal_epidermal_layer1.06388000
61MP0004264_abnormal_extraembryonic_tissu1.05737550
62MP0005670_abnormal_white_adipose1.05348092
63MP0003315_abnormal_perineum_morphology1.04355506
64MP0009703_decreased_birth_body1.03757951
65MP0010678_abnormal_skin_adnexa1.03651299
66MP0003635_abnormal_synaptic_transmissio1.02560822
67MP0002272_abnormal_nervous_system1.02173354
68MP0002697_abnormal_eye_size1.01287501
69MP0001293_anophthalmia0.99781643
70MP0004142_abnormal_muscle_tone0.99661573
71MP0003453_abnormal_keratinocyte_physiol0.99622677
72MP0003861_abnormal_nervous_system0.99569611
73MP0002084_abnormal_developmental_patter0.98987801
74MP0002064_seizures0.97654472
75MP0002085_abnormal_embryonic_tissue0.96974963
76MP0001348_abnormal_lacrimal_gland0.95102464
77MP0009745_abnormal_behavioral_response0.93886649
78MP0000383_abnormal_hair_follicle0.93714197
79MP0001697_abnormal_embryo_size0.93513714
80MP0000377_abnormal_hair_follicle0.92908884
81MP0003755_abnormal_palate_morphology0.90982262
82MP0000733_abnormal_muscle_development0.90385536
83MP0002938_white_spotting0.89889348
84MP0005375_adipose_tissue_phenotype0.89488623
85MP0003385_abnormal_body_wall0.88750327
86MP0002282_abnormal_trachea_morphology0.88361819
87MP0002822_catalepsy0.87035558
88MP0000566_synostosis0.86825198
89MP0000955_abnormal_spinal_cord0.86822984
90MP0002653_abnormal_ependyma_morphology0.85533933
91MP0000627_abnormal_mammary_gland0.83514759
92MP0002932_abnormal_joint_morphology0.83441526
93MP0000647_abnormal_sebaceous_gland0.83375754
94MP0004215_abnormal_myocardial_fiber0.83074501
95MP0005367_renal/urinary_system_phenotyp0.83059950
96MP0000516_abnormal_urinary_system0.83059950
97MP0003634_abnormal_glial_cell0.82667226
98MP0004197_abnormal_fetal_growth/weight/0.82374428
99MP0000428_abnormal_craniofacial_morphol0.82312725
100MP0002063_abnormal_learning/memory/cond0.82259474
101MP0003122_maternal_imprinting0.82060848
102MP0002734_abnormal_mechanical_nocicepti0.81777174
103MP0000049_abnormal_middle_ear0.80830408
104MP0003632_abnormal_nervous_system0.80800473
105MP0002114_abnormal_axial_skeleton0.80484334
106MP0003567_abnormal_fetal_cardiomyocyte0.79874683
107MP0002882_abnormal_neuron_morphology0.79811837
108MP0002163_abnormal_gland_morphology0.78667143
109MP0001672_abnormal_embryogenesis/_devel0.77745067
110MP0005380_embryogenesis_phenotype0.77745067
111MP0006035_abnormal_mitochondrial_morpho0.77187053
112MP0002210_abnormal_sex_determination0.77031589
113MP0000432_abnormal_head_morphology0.77022855
114MP0003119_abnormal_digestive_system0.76777350
115MP0004134_abnormal_chest_morphology0.76766601
116MP0000358_abnormal_cell_content/0.76736288
117MP0005384_cellular_phenotype0.76727756
118MP0004885_abnormal_endolymph0.76647141
119MP0002160_abnormal_reproductive_system0.76577740
120MP0001145_abnormal_male_reproductive0.75337856
121MP0003705_abnormal_hypodermis_morpholog0.75286800
122MP0003935_abnormal_craniofacial_develop0.75227055
123MP0002572_abnormal_emotion/affect_behav0.75216051
124MP0002152_abnormal_brain_morphology0.74884775
125MP0001881_abnormal_mammary_gland0.74344692
126MP0001879_abnormal_lymphatic_vessel0.73897005
127MP0003786_premature_aging0.73840695
128MP0005508_abnormal_skeleton_morphology0.73406796
129MP0003984_embryonic_growth_retardation0.73307832
130MP0004133_heterotaxia0.72493607
131MP0005621_abnormal_cell_physiology0.72387785
132MP0010630_abnormal_cardiac_muscle0.72368527
133MP0001968_abnormal_touch/_nociception0.72277974
134MP0000613_abnormal_salivary_gland0.72213941
135MP0002751_abnormal_autonomic_nervous0.71636579
136MP0004782_abnormal_surfactant_physiolog0.71338247
137MP0005187_abnormal_penis_morphology0.71323206
138MP0002006_tumorigenesis0.71259442
139MP0003943_abnormal_hepatobiliary_system0.71167613
140MP0002396_abnormal_hematopoietic_system0.70928283
141MP0001919_abnormal_reproductive_system0.70694017
142MP0005076_abnormal_cell_differentiation0.70620078
143MP0002269_muscular_atrophy0.70405683
144MP0002060_abnormal_skin_morphology0.69646048
145MP0001929_abnormal_gametogenesis0.69632319
146MP0000762_abnormal_tongue_morphology0.69448212
147MP0002177_abnormal_outer_ear0.69203465
148MP0002752_abnormal_somatic_nervous0.68689398
149MP0003936_abnormal_reproductive_system0.68189256
150MP0002088_abnormal_embryonic_growth/wei0.67724713
151MP0001191_abnormal_skin_condition0.67411558
152MP0001177_atelectasis0.67226095
153MP0002111_abnormal_tail_morphology0.66828348
154MP0003690_abnormal_glial_cell0.66756927
155MP0001727_abnormal_embryo_implantation0.66598219
156MP0001286_abnormal_eye_development0.66538754
157MP0009046_muscle_twitch0.66453134

Predicted human phenotypes

RankGene SetZ-score
1Degeneration of the lateral corticospinal tracts (HP:0002314)3.67618648
2Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)3.67618648
3Cerebral hypomyelination (HP:0006808)3.41102365
4Volvulus (HP:0002580)3.26604009
5Hypoplasia of the pons (HP:0012110)3.23644770
6Abnormality of the pons (HP:0007361)3.14032326
7Papillary thyroid carcinoma (HP:0002895)2.88941644
8Peripheral hypomyelination (HP:0007182)2.77786990
9Abnormality of the corticospinal tract (HP:0002492)2.71942051
10Septate vagina (HP:0001153)2.69808405
11Rhabdomyosarcoma (HP:0002859)2.66303520
12Nephroblastoma (Wilms tumor) (HP:0002667)2.63492161
13Multiple enchondromatosis (HP:0005701)2.63290293
14Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.60743900
15Adrenal hypoplasia (HP:0000835)2.59765093
16Cerebellar dysplasia (HP:0007033)2.59344343
17Parakeratosis (HP:0001036)2.53731471
18Stenosis of the external auditory canal (HP:0000402)2.50743022
19Fragile nails (HP:0001808)2.49704106
20Abnormality of chromosome stability (HP:0003220)2.48275982
21Embryonal renal neoplasm (HP:0011794)2.46556739
22Lip pit (HP:0100267)2.45780210
23Ankyloglossia (HP:0010296)2.44990416
24Hypoplastic pelvis (HP:0008839)2.44845359
25Reticulocytopenia (HP:0001896)2.43305481
26Abnormality of the labia minora (HP:0012880)2.37076916
27Aplasia involving forearm bones (HP:0009822)2.37053997
28Absent forearm bone (HP:0003953)2.37053997
29Esophageal atresia (HP:0002032)2.34843991
30Absent radius (HP:0003974)2.34537940
31Cortical dysplasia (HP:0002539)2.29827296
32Abnormality of the salivary glands (HP:0010286)2.29303252
33Colon cancer (HP:0003003)2.27879895
34Abnormality of the proximal phalanges of the hand (HP:0009834)2.27340432
35Increased nuchal translucency (HP:0010880)2.24612616
36Macrocytic anemia (HP:0001972)2.24563529
37Aqueductal stenosis (HP:0002410)2.18226854
38Birth length less than 3rd percentile (HP:0003561)2.16574641
39Fused cervical vertebrae (HP:0002949)2.15434006
40Deep philtrum (HP:0002002)2.15053838
41Selective tooth agenesis (HP:0001592)2.11579188
42Abnormality of the preputium (HP:0100587)2.10987538
43Hyperinsulinemic hypoglycemia (HP:0000825)2.10082251
44Abnormality of the nasal septum (HP:0000419)2.10063991
45Acute myeloid leukemia (HP:0004808)2.09297388
46Chin dimple (HP:0010751)2.08211991
47Breast hypoplasia (HP:0003187)2.07999110
48Meckel diverticulum (HP:0002245)2.06319742
49Progressive external ophthalmoplegia (HP:0000590)2.05088603
50Medulloblastoma (HP:0002885)2.04667903
51Non-midline cleft lip (HP:0100335)2.03514913
52Facial cleft (HP:0002006)2.03432362
53Abnormality of the ileum (HP:0001549)2.02269698
54Termporal pattern (HP:0011008)2.02163522
55Insidious onset (HP:0003587)2.02163522
56Neoplasm of striated muscle (HP:0009728)2.01629834
57Abnormality of the phalanges of the 2nd finger (HP:0009541)2.01189270
58Type II lissencephaly (HP:0007260)1.99263631
59Poikiloderma (HP:0001029)1.98331566
60Duplicated collecting system (HP:0000081)1.96829137
61Sensory axonal neuropathy (HP:0003390)1.95798107
62High anterior hairline (HP:0009890)1.95279167
63Asplenia (HP:0001746)1.93257648
64Irregular epiphyses (HP:0010582)1.92603110
65Abnormal hair whorl (HP:0010721)1.92197103
66Aplasia/Hypoplasia of the uvula (HP:0010293)1.91908080
67Increased serum pyruvate (HP:0003542)1.91817325
68Abnormality of glycolysis (HP:0004366)1.91817325
69Alacrima (HP:0000522)1.90684361
70Right ventricular cardiomyopathy (HP:0011663)1.90019117
71Hypoplastic labia majora (HP:0000059)1.89219026
72Postnatal microcephaly (HP:0005484)1.84473583
73Pallor (HP:0000980)1.83964837
74Overlapping toe (HP:0001845)1.83280824
75Aplasia/Hypoplasia of the sacrum (HP:0008517)1.83147990
76Premature ovarian failure (HP:0008209)1.82410680
77Morphological abnormality of the inner ear (HP:0011390)1.81313623
78Abnormal auditory evoked potentials (HP:0006958)1.81281871
79Autoamputation (HP:0001218)1.80816771
80Uterine neoplasm (HP:0010784)1.80530733
81Septo-optic dysplasia (HP:0100842)1.80243770
82Biliary tract neoplasm (HP:0100574)1.79492086
83Absent septum pellucidum (HP:0001331)1.78174786
84Pancreatic islet-cell hyperplasia (HP:0004510)1.77767828
85Uterine leiomyosarcoma (HP:0002891)1.77162332
86Leiomyosarcoma (HP:0100243)1.77162332
87Choanal atresia (HP:0000453)1.76438178
88CNS hypomyelination (HP:0003429)1.76289814
89Gastrointestinal carcinoma (HP:0002672)1.75187093
90Malignant gastrointestinal tract tumors (HP:0006749)1.75187093
91Aplasia/Hypoplasia of the spleen (HP:0010451)1.74932706
92Abnormality of the septum pellucidum (HP:0007375)1.74857209
93Sparse eyelashes (HP:0000653)1.74202190
94Megaloblastic anemia (HP:0001889)1.74148600
95Concave nail (HP:0001598)1.73941278
96Abnormality of the middle phalanges of the toes (HP:0010183)1.73834329
97Diastasis recti (HP:0001540)1.73796943
98Abnormality of the columella (HP:0009929)1.73173351
99Chromsome breakage (HP:0040012)1.72603055
100Atresia of the external auditory canal (HP:0000413)1.72327876
101Hypoglycemic seizures (HP:0002173)1.72040963
102Cafe-au-lait spot (HP:0000957)1.72000307
103Buphthalmos (HP:0000557)1.70900548
104Fatigue (HP:0012378)1.70752875
105Spastic gait (HP:0002064)1.70665085
106Glossoptosis (HP:0000162)1.70346686
107Abnormality of chromosome segregation (HP:0002916)1.70297511
108Abnormality of the renal collecting system (HP:0004742)1.70258831
109Abnormal number of incisors (HP:0011064)1.69962932
110Hypoplasia of the capital femoral epiphysis (HP:0003090)1.69632557
111Neoplasm of the oral cavity (HP:0100649)1.69293180
112Sparse lateral eyebrow (HP:0005338)1.68696359
113Ectopic kidney (HP:0000086)1.68500251
114Transitional cell carcinoma of the bladder (HP:0006740)1.68394666
115Generalized hypotonia (HP:0001290)1.67973502
116Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.67826862
117Absent eyelashes (HP:0000561)1.67648308
118Oligodactyly (HP:0012165)1.67568981
119Cupped ear (HP:0000378)1.66541676
120Missing ribs (HP:0000921)1.66196371
121Deviation of the thumb (HP:0009603)1.65544966
122Hypoglycemic coma (HP:0001325)1.65067723
123Entropion (HP:0000621)1.64992453
124Intestinal atresia (HP:0011100)1.64620744
125Chromosomal breakage induced by crosslinking agents (HP:0003221)1.64364779
126Decreased lacrimation (HP:0000633)1.64251067
127Small intestinal stenosis (HP:0012848)1.64145735
128Duodenal stenosis (HP:0100867)1.64145735
129Absent epiphyses (HP:0010577)1.64059456
130Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.64059456
131Supernumerary spleens (HP:0009799)1.63964771
132Abnormality of homocysteine metabolism (HP:0010919)1.63816429
133Homocystinuria (HP:0002156)1.63816429
134Gastrointestinal atresia (HP:0002589)1.62779873
135Macroorchidism (HP:0000053)1.62669649
136Abnormality of the labia majora (HP:0012881)1.62222074
137Abnormal lung lobation (HP:0002101)1.61739853
138Split foot (HP:0001839)1.61636824
139Proximal tubulopathy (HP:0000114)1.61182846
140Absent eyebrow (HP:0002223)1.60634257
141Small epiphyses (HP:0010585)1.60594813
142Curly hair (HP:0002212)1.60346049
143Relative macrocephaly (HP:0004482)1.60104248
144Long nose (HP:0003189)1.59168589
145Ankle clonus (HP:0011448)1.58931152
146Large earlobe (HP:0009748)1.56575205
147Patellar aplasia (HP:0006443)1.56238277
148Supernumerary bones of the axial skeleton (HP:0009144)1.55295631
149Carpal bone hypoplasia (HP:0001498)1.54632836
150Neurofibrillary tangles (HP:0002185)1.54126802
151Aplasia/hypoplasia of the humerus (HP:0006507)1.52676964
152Congenital ichthyosiform erythroderma (HP:0007431)1.52157736
153Oligodactyly (hands) (HP:0001180)1.52087611
154Aplasia/Hypoplasia of the patella (HP:0006498)1.49271435
155Facial hemangioma (HP:0000329)1.47020383
156Premature rupture of membranes (HP:0001788)1.46823238
157Mild short stature (HP:0003502)1.46175558
158Mutism (HP:0002300)1.45940836
159Abnormality of the fetal cardiovascular system (HP:0010948)1.45404852
160Abnormal umbilical cord blood vessels (HP:0011403)1.45404852
161Single umbilical artery (HP:0001195)1.45404852
162Abnormality of the umbilical cord (HP:0010881)1.43668288
163Premature graying of hair (HP:0002216)1.42879584
164Dysmetria (HP:0001310)1.42591403
165Depressed nasal tip (HP:0000437)1.41862604
166Proximal placement of thumb (HP:0009623)1.41269076
167Broad alveolar ridges (HP:0000187)1.40005338
168Bowel incontinence (HP:0002607)1.39260434
169Abnormal large intestine physiology (HP:0012700)1.38881297
170Coronal craniosynostosis (HP:0004440)1.37377223
171Heterochromia iridis (HP:0001100)1.37236055
172Synostosis involving the elbow (HP:0003938)1.36211481
173Humeroradial synostosis (HP:0003041)1.36211481
174Aplasia/Hypoplasia of the sternum (HP:0006714)1.36082048
175Myokymia (HP:0002411)1.36075150
176Supernumerary ribs (HP:0005815)1.35592050
177Nemaline bodies (HP:0003798)1.34997666
178Rib fusion (HP:0000902)1.34944155

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK393.63376073
2NEK13.26585404
3PRPF4B2.86379871
4BUB12.85788276
5BCR2.78025303
6PNCK2.52620648
7MKNK12.50425063
8WEE12.42235429
9OXSR12.31841152
10CAMK1G2.13892672
11TESK22.10325731
12CDK122.10116252
13STK101.95505221
14TAF11.95469748
15CDK191.91404077
16PBK1.86538844
17CASK1.84212996
18CAMK1D1.82816721
19CLK11.81562941
20MKNK21.75597845
21MAPKAPK51.69818218
22EPHB11.68517081
23BRAF1.64286615
24UHMK11.62520410
25LIMK11.62156043
26NEK61.57454216
27TNIK1.55128162
28EPHA41.52956806
29TSSK61.52644992
30LATS11.49831478
31SRPK11.47534787
32CDC71.43416181
33PLK31.41497306
34PLK21.40096824
35MARK31.35665921
36TYRO31.32106803
37EIF2AK11.30642347
38NUAK11.29755780
39MST41.29184469
40STK41.26698160
41LATS21.26069858
42DYRK21.25310154
43TRIM281.24198075
44EEF2K1.21995536
45BRD41.13456745
46ICK1.13184806
47CDK141.12684650
48PLK41.09984459
49BRSK21.07855369
50FGFR21.05914528
51NEK21.02858631
52MET1.01933891
53EPHA21.01720066
54FGR1.01263503
55EIF2AK21.00121279
56RPS6KB20.96469885
57DYRK30.95814231
58NLK0.95569009
59CDK70.93435739
60MARK10.93215983
61CSNK1G30.93168588
62WNK10.93143768
63KSR10.91074964
64STK240.91024296
65MAP3K120.90410632
66CSNK1A1L0.88889447
67PRKD30.85394631
68AURKB0.84707132
69AURKA0.83375811
70PLK10.81073711
71MAP3K110.80906139
72VRK10.80376045
73ALK0.80368700
74CDK180.79734250
75MINK10.78336961
76MAP3K80.78005504
77SMG10.77244705
78STK160.76664674
79FES0.75977636
80ARAF0.75853025
81CDK150.74686661
82NTRK30.73729567
83ACVR1B0.73662317
84DMPK0.73493728
85ROCK20.73461021
86CDK11A0.71183880
87SIK30.69577074
88CHEK10.68277814
89BMPR1B0.68132969
90PKN10.67771810
91FGFR10.66408250
92NME20.65041639
93CSNK1G10.64828696
94TTK0.62763787
95AKT30.61895414
96KSR20.61388079
97CAMK2B0.60633569
98ERBB30.60256353
99ERBB40.59264022
100NTRK10.56346472
101MAPK130.54850499
102PIM20.54722325
103RPS6KA50.53483013
104RAF10.51357036
105PIM10.50937471
106STK30.49015154
107CSNK1E0.48965150
108STK110.48799351
109CDK10.48510110
110TGFBR10.48389978
111PAK10.48314372
112YES10.47941369
113BRSK10.46916322
114MAPK100.46795893
115CSNK1G20.46450620
116CAMK2D0.46206860
117NME10.45905574
118CDK20.45131155
119CCNB10.45067176
120CDK60.44871898
121CSNK1D0.44640843
122CHEK20.44395278
123ATM0.43929737
124MTOR0.43745647
125MAP3K100.42589674
126MAP3K90.41494129
127CDK50.41398233
128ATR0.40237639
129IRAK20.40042576
130SGK30.39610888
131VRK20.39337445
132MELK0.39154254
133CDK30.38447158
134MOS0.38310395
135MAP3K130.37426999
136CAMK2A0.36584142
137EIF2AK30.36499838
138AKT20.35907773
139SCYL20.35696179
140PTK20.34895387
141SGK20.34500738
142CSNK2A20.34381848
143PASK0.34200514
144CDK40.33791486
145MAP3K60.33536336
146MAP3K140.33194939
147CDK90.33110476
148DYRK1A0.30688418
149WNK30.30565877

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.47899007
2RNA polymerase_Homo sapiens_hsa030202.33978458
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.18429155
4Spliceosome_Homo sapiens_hsa030402.03249198
5One carbon pool by folate_Homo sapiens_hsa006701.90327519
6DNA replication_Homo sapiens_hsa030301.79391341
7Basal transcription factors_Homo sapiens_hsa030221.76215463
8Proteasome_Homo sapiens_hsa030501.62589867
9RNA transport_Homo sapiens_hsa030131.60964839
10Mismatch repair_Homo sapiens_hsa034301.60235803
11Cell cycle_Homo sapiens_hsa041101.58694010
12Homologous recombination_Homo sapiens_hsa034401.52155838
13Cysteine and methionine metabolism_Homo sapiens_hsa002701.50865559
14Nucleotide excision repair_Homo sapiens_hsa034201.41068806
15* mRNA surveillance pathway_Homo sapiens_hsa030151.37166882
16Steroid biosynthesis_Homo sapiens_hsa001001.36550346
17Oocyte meiosis_Homo sapiens_hsa041141.35177715
18Base excision repair_Homo sapiens_hsa034101.35076476
19Axon guidance_Homo sapiens_hsa043601.33006164
20Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.31111126
21Ether lipid metabolism_Homo sapiens_hsa005651.28809023
22Folate biosynthesis_Homo sapiens_hsa007901.24703148
23Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.22467389
24Hedgehog signaling pathway_Homo sapiens_hsa043401.21392240
25Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.16862763
26Fanconi anemia pathway_Homo sapiens_hsa034601.16827359
27Non-homologous end-joining_Homo sapiens_hsa034501.15054126
28Shigellosis_Homo sapiens_hsa051311.14269453
29Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.14109621
30Selenocompound metabolism_Homo sapiens_hsa004501.13654870
31Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.07729709
32Pyruvate metabolism_Homo sapiens_hsa006201.07039714
33Renal cell carcinoma_Homo sapiens_hsa052111.06812479
34RNA degradation_Homo sapiens_hsa030181.05415276
35Vitamin B6 metabolism_Homo sapiens_hsa007501.04141767
36Long-term depression_Homo sapiens_hsa047301.03702583
37* Hippo signaling pathway_Homo sapiens_hsa043901.02927806
38Serotonergic synapse_Homo sapiens_hsa047260.99082162
39Wnt signaling pathway_Homo sapiens_hsa043100.98145676
40Basal cell carcinoma_Homo sapiens_hsa052170.96426450
41Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.96136762
42TGF-beta signaling pathway_Homo sapiens_hsa043500.95678371
43Sphingolipid metabolism_Homo sapiens_hsa006000.95316625
44Ribosome_Homo sapiens_hsa030100.94297786
45Chronic myeloid leukemia_Homo sapiens_hsa052200.93497670
46* Tight junction_Homo sapiens_hsa045300.92641626
47* Sphingolipid signaling pathway_Homo sapiens_hsa040710.92033145
48Epstein-Barr virus infection_Homo sapiens_hsa051690.91849954
49MicroRNAs in cancer_Homo sapiens_hsa052060.90005036
50ErbB signaling pathway_Homo sapiens_hsa040120.83912437
51Thyroid cancer_Homo sapiens_hsa052160.81754822
52Huntingtons disease_Homo sapiens_hsa050160.80734469
53Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.80006672
54Salmonella infection_Homo sapiens_hsa051320.78800656
55Pyrimidine metabolism_Homo sapiens_hsa002400.78444869
56Pancreatic cancer_Homo sapiens_hsa052120.78111358
57SNARE interactions in vesicular transport_Homo sapiens_hsa041300.77764927
58p53 signaling pathway_Homo sapiens_hsa041150.75536577
59Small cell lung cancer_Homo sapiens_hsa052220.74474432
60T cell receptor signaling pathway_Homo sapiens_hsa046600.74296979
61Circadian rhythm_Homo sapiens_hsa047100.74107204
62Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.74006284
63Endometrial cancer_Homo sapiens_hsa052130.73459266
64* Dopaminergic synapse_Homo sapiens_hsa047280.72876858
65Gap junction_Homo sapiens_hsa045400.72782092
66Regulation of actin cytoskeleton_Homo sapiens_hsa048100.72351959
67Protein export_Homo sapiens_hsa030600.71537174
68Glutamatergic synapse_Homo sapiens_hsa047240.71262362
69Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.69901959
70Dorso-ventral axis formation_Homo sapiens_hsa043200.69773106
71Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.68895304
72Allograft rejection_Homo sapiens_hsa053300.68549278
73Bladder cancer_Homo sapiens_hsa052190.67756224
74Long-term potentiation_Homo sapiens_hsa047200.67278652
75Ras signaling pathway_Homo sapiens_hsa040140.67140650
76Melanogenesis_Homo sapiens_hsa049160.66707048
77Autoimmune thyroid disease_Homo sapiens_hsa053200.64725498
78Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.64353755
79Pathways in cancer_Homo sapiens_hsa052000.64162149
80Endocytosis_Homo sapiens_hsa041440.63428766
81MAPK signaling pathway_Homo sapiens_hsa040100.62749496
82Cocaine addiction_Homo sapiens_hsa050300.61979137
83Rheumatoid arthritis_Homo sapiens_hsa053230.61432561
84Purine metabolism_Homo sapiens_hsa002300.61226497
85Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.60664057
86Morphine addiction_Homo sapiens_hsa050320.60453445
87Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.60401242
88Fatty acid elongation_Homo sapiens_hsa000620.59871400
89FoxO signaling pathway_Homo sapiens_hsa040680.59232172
90Parkinsons disease_Homo sapiens_hsa050120.58667437
91Amphetamine addiction_Homo sapiens_hsa050310.58503052
92Viral carcinogenesis_Homo sapiens_hsa052030.58437278
93Choline metabolism in cancer_Homo sapiens_hsa052310.57784700
94Prostate cancer_Homo sapiens_hsa052150.56936078
95Herpes simplex infection_Homo sapiens_hsa051680.56165555
96Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.55232560
97Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.55174307
98Phospholipase D signaling pathway_Homo sapiens_hsa040720.54538326
99HTLV-I infection_Homo sapiens_hsa051660.54369710
100Oxytocin signaling pathway_Homo sapiens_hsa049210.53983173
101Viral myocarditis_Homo sapiens_hsa054160.53487445
102Rap1 signaling pathway_Homo sapiens_hsa040150.53295151
103Propanoate metabolism_Homo sapiens_hsa006400.53166005
104Cholinergic synapse_Homo sapiens_hsa047250.52539169
105Chemokine signaling pathway_Homo sapiens_hsa040620.52309815
106Colorectal cancer_Homo sapiens_hsa052100.52266276
107NOD-like receptor signaling pathway_Homo sapiens_hsa046210.52022758
108Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.52008139
109Longevity regulating pathway - mammal_Homo sapiens_hsa042110.51762738
110Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.51700475
111Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.51468426
112Melanoma_Homo sapiens_hsa052180.51130818
113Adherens junction_Homo sapiens_hsa045200.50602174
114Glioma_Homo sapiens_hsa052140.50395101
115* PI3K-Akt signaling pathway_Homo sapiens_hsa041510.50357944
116Insulin signaling pathway_Homo sapiens_hsa049100.50240332
1172-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.49988255
118VEGF signaling pathway_Homo sapiens_hsa043700.49477511
119Asthma_Homo sapiens_hsa053100.49453987
120Leukocyte transendothelial migration_Homo sapiens_hsa046700.47569366
121Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.46415295
122GnRH signaling pathway_Homo sapiens_hsa049120.45800891
123Oxidative phosphorylation_Homo sapiens_hsa001900.45533029
124Non-small cell lung cancer_Homo sapiens_hsa052230.45438564
125Hepatitis B_Homo sapiens_hsa051610.45136495
126Proteoglycans in cancer_Homo sapiens_hsa052050.44918843
127Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.43432314
128Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.42925095
129Lysine degradation_Homo sapiens_hsa003100.42634041
130Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.39333435
131Thyroid hormone signaling pathway_Homo sapiens_hsa049190.37763675
132Biosynthesis of amino acids_Homo sapiens_hsa012300.35676633
133* Hepatitis C_Homo sapiens_hsa051600.34541820
134Carbon metabolism_Homo sapiens_hsa012000.33271915
135Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.31620462
136Prolactin signaling pathway_Homo sapiens_hsa049170.31351785
137Central carbon metabolism in cancer_Homo sapiens_hsa052300.30047811
138mTOR signaling pathway_Homo sapiens_hsa041500.29567002
139Glutathione metabolism_Homo sapiens_hsa004800.28906039
140Alzheimers disease_Homo sapiens_hsa050100.28619393
141Inositol phosphate metabolism_Homo sapiens_hsa005620.27237149
142Apoptosis_Homo sapiens_hsa042100.27034288
143Glucagon signaling pathway_Homo sapiens_hsa049220.26760045
144Measles_Homo sapiens_hsa051620.25817487
145* AMPK signaling pathway_Homo sapiens_hsa041520.24681293
146Vitamin digestion and absorption_Homo sapiens_hsa049770.21781520

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