PPP2R2B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The product of this gene belongs to the phosphatase 2 regulatory subunit B family. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a beta isoform of the regulatory subunit B55 subfamily. Defects in this gene cause autosomal dominant spinocerebellar ataxia 12 (SCA12), a disease caused by degeneration of the cerebellum, sometimes involving the brainstem and spinal cord, and in resulting in poor coordination of speech and body movements. Multiple alternatively spliced variants, which encode different isoforms, have been identified for this gene. The 5' UTR of some of these variants includes a CAG trinucleotide repeat sequence (7-28 copies) that can be expanded to 55-78 copies in cases of SCA12. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle exocytosis (GO:0016079)5.62635327
2vocalization behavior (GO:0071625)5.59902664
3protein localization to synapse (GO:0035418)5.40634728
4neuron cell-cell adhesion (GO:0007158)5.34731513
5regulation of short-term neuronal synaptic plasticity (GO:0048172)5.34071976
6regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.01196214
7positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.91227487
8positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.90700226
9glutamate secretion (GO:0014047)4.82831243
10regulation of synaptic vesicle exocytosis (GO:2000300)4.73227431
11synaptic vesicle maturation (GO:0016188)4.71951302
12locomotory exploration behavior (GO:0035641)4.53098086
13regulation of glutamate receptor signaling pathway (GO:1900449)4.47226226
14neurotransmitter secretion (GO:0007269)4.27393251
15synaptic vesicle docking involved in exocytosis (GO:0016081)4.20524013
16exploration behavior (GO:0035640)4.19531962
17postsynaptic membrane organization (GO:0001941)4.16703597
18regulation of synaptic vesicle transport (GO:1902803)4.15542217
19regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.15534987
20neurotransmitter-gated ion channel clustering (GO:0072578)4.13721030
21layer formation in cerebral cortex (GO:0021819)3.97560049
22ionotropic glutamate receptor signaling pathway (GO:0035235)3.91888260
23proline transport (GO:0015824)3.84465561
24regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.83429045
25glutamate receptor signaling pathway (GO:0007215)3.83200541
26regulation of synapse structural plasticity (GO:0051823)3.79386624
27neuron-neuron synaptic transmission (GO:0007270)3.77980192
28positive regulation of synapse maturation (GO:0090129)3.77771080
29neuronal action potential propagation (GO:0019227)3.76589381
30neuron recognition (GO:0008038)3.73523397
31synaptic transmission, glutamatergic (GO:0035249)3.71149526
32nucleobase catabolic process (GO:0046113)3.70442547
33presynaptic membrane assembly (GO:0097105)3.68650060
34neurotransmitter transport (GO:0006836)3.60519660
35gamma-aminobutyric acid signaling pathway (GO:0007214)3.57540573
36positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.56540003
37cell migration in hindbrain (GO:0021535)3.56198744
38regulation of neuronal synaptic plasticity (GO:0048168)3.55247321
39axon ensheathment in central nervous system (GO:0032291)3.50273524
40central nervous system myelination (GO:0022010)3.50273524
41negative regulation of synaptic transmission, GABAergic (GO:0032229)3.50111281
42regulation of long-term neuronal synaptic plasticity (GO:0048169)3.49582961
43innervation (GO:0060384)3.47649483
44regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.47171344
45regulation of neurotransmitter secretion (GO:0046928)3.46567471
46long-term synaptic potentiation (GO:0060291)3.46317269
47dendritic spine morphogenesis (GO:0060997)3.43221961
48regulation of vesicle fusion (GO:0031338)3.42304317
49cerebellar granule cell differentiation (GO:0021707)3.41899028
50synaptic vesicle endocytosis (GO:0048488)3.41345956
51synapse assembly (GO:0007416)3.41087757
52membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.41079387
53cellular potassium ion homeostasis (GO:0030007)3.40861429
54establishment of mitochondrion localization (GO:0051654)3.39154901
55regulation of excitatory postsynaptic membrane potential (GO:0060079)3.38903374
56presynaptic membrane organization (GO:0097090)3.38130415
57response to histamine (GO:0034776)3.37541929
58L-amino acid import (GO:0043092)3.35461255
59positive regulation of membrane potential (GO:0045838)3.34754510
60auditory behavior (GO:0031223)3.34313970
61response to auditory stimulus (GO:0010996)3.31560202
62adult walking behavior (GO:0007628)3.31209358
63regulation of postsynaptic membrane potential (GO:0060078)3.30944413
64neuronal ion channel clustering (GO:0045161)3.30811536
65regulation of synaptic transmission, glutamatergic (GO:0051966)3.29140138
66neurotransmitter uptake (GO:0001504)3.25658765
67axonal fasciculation (GO:0007413)3.25158668
68sodium ion export (GO:0071436)3.24820423
69G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.24616498
70regulation of neurotransmitter levels (GO:0001505)3.23568035
71C4-dicarboxylate transport (GO:0015740)3.23315845
72central nervous system projection neuron axonogenesis (GO:0021952)3.22589673
73positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.22044990
74gamma-aminobutyric acid transport (GO:0015812)3.21016280
75regulation of neurotransmitter transport (GO:0051588)3.20978329
76negative regulation of microtubule polymerization (GO:0031115)3.20251640
77positive regulation of neurotransmitter transport (GO:0051590)3.15876375
78transmission of nerve impulse (GO:0019226)3.15862966
79long-term memory (GO:0007616)3.15157165
80regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.08682879
81positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.06866287
82regulation of synaptic plasticity (GO:0048167)3.06862207
83positive regulation of synapse assembly (GO:0051965)3.06726914
84potassium ion import (GO:0010107)3.06265982
85positive regulation of synaptic transmission, GABAergic (GO:0032230)3.05431171
86membrane hyperpolarization (GO:0060081)3.04478052
87membrane depolarization during action potential (GO:0086010)3.02908087
88regulation of voltage-gated calcium channel activity (GO:1901385)3.00519083
89mating behavior (GO:0007617)3.00443586
90behavioral response to cocaine (GO:0048148)3.00262542
91regulation of neurotransmitter uptake (GO:0051580)2.99863785
92behavioral fear response (GO:0001662)2.99726230
93behavioral defense response (GO:0002209)2.99726230
94synaptic vesicle transport (GO:0048489)2.99474303
95establishment of synaptic vesicle localization (GO:0097480)2.99474303
96dendrite morphogenesis (GO:0048813)2.99286998
97pyrimidine nucleobase catabolic process (GO:0006208)2.97507198
98synaptic transmission (GO:0007268)2.97505374
99positive regulation of dendritic spine development (GO:0060999)2.97279506
100regulation of synapse maturation (GO:0090128)2.96752664
101fear response (GO:0042596)2.96557890
102negative regulation of dendrite development (GO:2000171)2.96353185
103serotonin metabolic process (GO:0042428)2.95946749
104regulation of dendritic spine morphogenesis (GO:0061001)2.95388699
105mechanosensory behavior (GO:0007638)2.95289835
106learning (GO:0007612)2.94914529
107positive regulation of dendritic spine morphogenesis (GO:0061003)2.94692596
108vesicle transport along microtubule (GO:0047496)2.94007119
109membrane depolarization (GO:0051899)2.93782933
110cerebellar Purkinje cell differentiation (GO:0021702)2.93525612
111neuromuscular synaptic transmission (GO:0007274)2.92889569
112startle response (GO:0001964)2.92565905
113positive regulation of synaptic transmission (GO:0050806)2.92552864
114striatum development (GO:0021756)2.92190933
115cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.91509778
116positive regulation of neurotransmitter secretion (GO:0001956)2.91169023
117synapse organization (GO:0050808)2.91160211
118negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.89903692
119activation of protein kinase A activity (GO:0034199)2.89004282
120neurofilament cytoskeleton organization (GO:0060052)2.88601927
121prepulse inhibition (GO:0060134)2.88001314
122establishment of vesicle localization (GO:0051650)2.85638396
123cochlea development (GO:0090102)2.84328243
124acidic amino acid transport (GO:0015800)2.82067414
125adult behavior (GO:0030534)2.81769481
126regulation of dendritic spine development (GO:0060998)2.81158803

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.76155631
2* GBX2_23144817_ChIP-Seq_PC3_Human3.73481251
3* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.14423489
4JARID2_20064375_ChIP-Seq_MESCs_Mouse3.05300864
5* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.93509816
6* REST_21632747_ChIP-Seq_MESCs_Mouse2.78525167
7JARID2_20075857_ChIP-Seq_MESCs_Mouse2.64418498
8EZH2_27304074_Chip-Seq_ESCs_Mouse2.62357210
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.60815604
10RNF2_18974828_ChIP-Seq_MESCs_Mouse2.60815604
11SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.59863794
12* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.57693355
13SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.46736171
14NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.45220925
15* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.43612026
16* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.40485646
17EED_16625203_ChIP-ChIP_MESCs_Mouse2.34342289
18GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.28890503
19REST_18959480_ChIP-ChIP_MESCs_Mouse2.25398474
20SUZ12_27294783_Chip-Seq_ESCs_Mouse2.23397858
21EZH2_27294783_Chip-Seq_ESCs_Mouse2.21771331
22TAF15_26573619_Chip-Seq_HEK293_Human2.20526184
23CTBP2_25329375_ChIP-Seq_LNCAP_Human2.17922177
24RNF2_27304074_Chip-Seq_ESCs_Mouse2.13518833
25RARB_27405468_Chip-Seq_BRAIN_Mouse2.05102335
26AR_21572438_ChIP-Seq_LNCaP_Human2.00374462
27DROSHA_22980978_ChIP-Seq_HELA_Human1.98635528
28CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.97084770
29* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.96431795
30IKZF1_21737484_ChIP-ChIP_HCT116_Human1.85118413
31* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.83485314
32TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.81109561
33* SMAD4_21799915_ChIP-Seq_A2780_Human1.77292917
34BMI1_23680149_ChIP-Seq_NPCS_Mouse1.71427535
35* ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.68087842
36PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.66608008
37GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.64983011
38* P300_19829295_ChIP-Seq_ESCs_Human1.64681763
39CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.64227661
40CBX2_27304074_Chip-Seq_ESCs_Mouse1.61041741
41SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.59755620
42PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.54759884
43ZNF274_21170338_ChIP-Seq_K562_Hela1.52395385
44TOP2B_26459242_ChIP-Seq_MCF-7_Human1.48676847
45RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.47906645
46MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.46012783
47RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.45465599
48SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.45358815
49IGF1R_20145208_ChIP-Seq_DFB_Human1.44703315
50AR_25329375_ChIP-Seq_VCAP_Human1.44094639
51POU3F2_20337985_ChIP-ChIP_501MEL_Human1.42667791
52RNF2_27304074_Chip-Seq_NSC_Mouse1.41352338
53NR3C1_23031785_ChIP-Seq_PC12_Mouse1.40579348
54HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.39310534
55SMAD3_21741376_ChIP-Seq_EPCs_Human1.37853020
56PIAS1_25552417_ChIP-Seq_VCAP_Human1.35339566
57OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.34245611
58VDR_22108803_ChIP-Seq_LS180_Human1.30921217
59SOX2_21211035_ChIP-Seq_LN229_Gbm1.30274226
60* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.30268499
61ERG_21242973_ChIP-ChIP_JURKAT_Human1.29541491
62EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.29534818
63RING1B_27294783_Chip-Seq_ESCs_Mouse1.25573576
64FUS_26573619_Chip-Seq_HEK293_Human1.23619835
65FLI1_27457419_Chip-Seq_LIVER_Mouse1.23008107
66TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.19774052
67CDX2_19796622_ChIP-Seq_MESCs_Mouse1.18894078
68* STAT3_23295773_ChIP-Seq_U87_Human1.17623950
69CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17175508
70* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.16431442
71P53_22127205_ChIP-Seq_FIBROBLAST_Human1.16152976
72RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.14094802
73EWS_26573619_Chip-Seq_HEK293_Human1.13871712
74AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.12460634
75* AR_19668381_ChIP-Seq_PC3_Human1.09773983
76KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.09505217
77SMAD_19615063_ChIP-ChIP_OVARY_Human1.08942613
78PRDM14_20953172_ChIP-Seq_ESCs_Human1.08735762
79RUNX2_22187159_ChIP-Seq_PCA_Human1.08573515
80PCGF2_27294783_Chip-Seq_ESCs_Mouse1.07788988
81* TCF4_23295773_ChIP-Seq_U87_Human1.07786679
82MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.07325882
83ER_23166858_ChIP-Seq_MCF-7_Human1.07301298
84ARNT_22903824_ChIP-Seq_MCF-7_Human1.06740000
85* SOX9_26525672_Chip-Seq_HEART_Mouse1.06674564
86MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.06564773
87LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05315321
88RING1B_27294783_Chip-Seq_NPCs_Mouse1.04501682
89* JUN_21703547_ChIP-Seq_K562_Human1.04100513
90TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.03110194
91BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.03025650
92* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02873060
93AHR_22903824_ChIP-Seq_MCF-7_Human1.02275640
94POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.01599289
95TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01599289
96* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.01431868
97ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.97058483
98STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.96672752
99EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.96313874
100* SMAD3_21741376_ChIP-Seq_ESCs_Human0.95204095
101TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.93655674
102IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.92344461
103CBP_20019798_ChIP-Seq_JUKART_Human0.92344461
104FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.92051523
105NANOG_18555785_Chip-Seq_ESCs_Mouse0.91734004
106NR3C1_21868756_ChIP-Seq_MCF10A_Human0.91276832
107KDM2B_26808549_Chip-Seq_REH_Human0.91098815
108SMAD4_21741376_ChIP-Seq_HESCs_Human0.90970244
109BCAT_22108803_ChIP-Seq_LS180_Human0.90355790
110WT1_25993318_ChIP-Seq_PODOCYTE_Human0.90354739
111MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.88869993
112TP53_18474530_ChIP-ChIP_U2OS_Human0.88044780
113* CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.87805710

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.07351104
2MP0003880_abnormal_central_pattern4.55007085
3MP0003635_abnormal_synaptic_transmissio3.73864376
4MP0004270_analgesia3.64160547
5MP0001968_abnormal_touch/_nociception3.29102206
6MP0009745_abnormal_behavioral_response3.11291266
7MP0002063_abnormal_learning/memory/cond3.07963346
8MP0002064_seizures2.88273340
9MP0005423_abnormal_somatic_nervous2.86779733
10MP0002734_abnormal_mechanical_nocicepti2.86288371
11MP0009046_muscle_twitch2.85863065
12MP0002736_abnormal_nociception_after2.74865595
13MP0002572_abnormal_emotion/affect_behav2.68235680
14MP0002735_abnormal_chemical_nociception2.64368748
15MP0002822_catalepsy2.55010366
16MP0002272_abnormal_nervous_system2.48527458
17MP0006276_abnormal_autonomic_nervous2.41994694
18MP0001486_abnormal_startle_reflex2.41911289
19MP0002733_abnormal_thermal_nociception2.23856128
20MP0005551_abnormal_eye_electrophysiolog2.19434251
21MP0001440_abnormal_grooming_behavior2.16870958
22MP0001984_abnormal_olfaction2.13705730
23MP0001970_abnormal_pain_threshold2.11610923
24MP0002067_abnormal_sensory_capabilities2.08891499
25MP0002184_abnormal_innervation2.08697962
26MP0000778_abnormal_nervous_system2.03205599
27MP0001501_abnormal_sleep_pattern1.98911412
28MP0004858_abnormal_nervous_system1.88750148
29MP0002557_abnormal_social/conspecific_i1.78152289
30MP0004924_abnormal_behavior1.77106626
31MP0005386_behavior/neurological_phenoty1.77106626
32MP0001529_abnormal_vocalization1.75596748
33MP0008877_abnormal_DNA_methylation1.72532584
34MP0003329_amyloid_beta_deposits1.68299363
35MP0005646_abnormal_pituitary_gland1.67693546
36MP0004811_abnormal_neuron_physiology1.63921563
37MP0009780_abnormal_chondrocyte_physiolo1.63474759
38MP0008569_lethality_at_weaning1.57713119
39MP0002882_abnormal_neuron_morphology1.57659778
40MP0001905_abnormal_dopamine_level1.57589281
41MP0000955_abnormal_spinal_cord1.56426968
42MP0002638_abnormal_pupillary_reflex1.53308038
43MP0001502_abnormal_circadian_rhythm1.49055147
44MP0005645_abnormal_hypothalamus_physiol1.44795903
45MP0003879_abnormal_hair_cell1.43902122
46MP0003121_genomic_imprinting1.42981666
47MP0001188_hyperpigmentation1.39574445
48MP0006072_abnormal_retinal_apoptosis1.38816875
49MP0003122_maternal_imprinting1.38436244
50MP0010386_abnormal_urinary_bladder1.37920411
51MP0004142_abnormal_muscle_tone1.37709533
52MP0002066_abnormal_motor_capabilities/c1.34235141
53MP0002909_abnormal_adrenal_gland1.29923625
54MP0003787_abnormal_imprinting1.29614096
55MP0005253_abnormal_eye_physiology1.23446811
56MP0002229_neurodegeneration1.20369330
57MP0003690_abnormal_glial_cell1.19922446
58MP0000751_myopathy1.18333349
59MP0002752_abnormal_somatic_nervous1.17429207
60MP0005394_taste/olfaction_phenotype1.12955165
61MP0005499_abnormal_olfactory_system1.12955165
62MP0002090_abnormal_vision1.12768726
63MP0003633_abnormal_nervous_system1.12243873
64MP0002152_abnormal_brain_morphology1.10184118
65MP0003136_yellow_coat_color1.09219832
66MP0004885_abnormal_endolymph1.04262798
67MP0000631_abnormal_neuroendocrine_gland1.01907450
68MP0000920_abnormal_myelination1.00622813
69MP0002876_abnormal_thyroid_physiology1.00509942
70MP0002837_dystrophic_cardiac_calcinosis0.99956254
71MP0003631_nervous_system_phenotype0.99229745
72MP0001963_abnormal_hearing_physiology0.96928460
73MP0006292_abnormal_olfactory_placode0.94740389
74MP0003634_abnormal_glial_cell0.94368693
75MP0004742_abnormal_vestibular_system0.93799313
76MP0008872_abnormal_physiological_respon0.92700318
77MP0001986_abnormal_taste_sensitivity0.92139754
78MP0004133_heterotaxia0.90846512
79MP0002069_abnormal_eating/drinking_beha0.88988685
80MP0002751_abnormal_autonomic_nervous0.88520027
81MP0003011_delayed_dark_adaptation0.85194306
82MP0005195_abnormal_posterior_eye0.82066136
83MP0000569_abnormal_digit_pigmentation0.81645359
84MP0005535_abnormal_body_temperature0.75224144
85MP0008789_abnormal_olfactory_epithelium0.75023994
86MP0004085_abnormal_heartbeat0.74990465
87MP0000566_synostosis0.74891138
88MP0004233_abnormal_muscle_weight0.74234730
89MP0005187_abnormal_penis_morphology0.73510545
90MP0004215_abnormal_myocardial_fiber0.73238957
91MP0000026_abnormal_inner_ear0.72437039
92MP0003632_abnormal_nervous_system0.70297815
93MP0004147_increased_porphyrin_level0.70109034
94MP0004145_abnormal_muscle_electrophysio0.69924681
95MP0002653_abnormal_ependyma_morphology0.69777034
96MP0001664_abnormal_digestion0.67432218
97MP0008874_decreased_physiological_sensi0.67208491
98MP0000604_amyloidosis0.67204446
99MP0005409_darkened_coat_color0.66312246
100MP0003938_abnormal_ear_development0.64845988
101MP0002102_abnormal_ear_morphology0.64634379
102MP0003890_abnormal_embryonic-extraembry0.64297357
103MP0000013_abnormal_adipose_tissue0.63345800
104MP0003861_abnormal_nervous_system0.62609139
105MP0010769_abnormal_survival0.60821469
106MP0003123_paternal_imprinting0.60602960
107MP0004043_abnormal_pH_regulation0.60001163
108MP0001299_abnormal_eye_distance/0.58932482
109MP0001177_atelectasis0.56484066
110MP0001943_abnormal_respiration0.54865771
111MP0001485_abnormal_pinna_reflex0.54511541
112MP0003137_abnormal_impulse_conducting0.54268238
113MP0002082_postnatal_lethality0.49644330
114MP0010770_preweaning_lethality0.49644330

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.68699096
2* Myokymia (HP:0002411)5.31127229
3Focal seizures (HP:0007359)5.07826291
4Epileptic encephalopathy (HP:0200134)5.04512863
5Atonic seizures (HP:0010819)4.67287478
6Visual hallucinations (HP:0002367)4.61410251
7Febrile seizures (HP:0002373)4.58567348
8Hyperventilation (HP:0002883)4.48840601
9Absence seizures (HP:0002121)4.20773641
10Congenital stationary night blindness (HP:0007642)3.84880273
11Dialeptic seizures (HP:0011146)3.74208160
12Generalized tonic-clonic seizures (HP:0002069)3.61869662
13* Progressive cerebellar ataxia (HP:0002073)3.45806248
14Limb dystonia (HP:0002451)3.37334061
15Gait imbalance (HP:0002141)3.21210898
16Supranuclear gaze palsy (HP:0000605)3.16413723
17Diplopia (HP:0000651)3.13352441
18Abnormality of binocular vision (HP:0011514)3.13352441
19Broad-based gait (HP:0002136)3.12743072
20Amblyopia (HP:0000646)3.05009936
21Abnormality of the labia minora (HP:0012880)3.03748312
22Central scotoma (HP:0000603)3.03189651
23Mutism (HP:0002300)3.02080235
24Polyphagia (HP:0002591)3.01236374
25Ankle clonus (HP:0011448)2.98121902
26Pheochromocytoma (HP:0002666)2.89341678
27Abnormal eating behavior (HP:0100738)2.86310242
28Truncal ataxia (HP:0002078)2.80806995
29Drooling (HP:0002307)2.73330328
30Excessive salivation (HP:0003781)2.73330328
31Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.69933586
32Degeneration of the lateral corticospinal tracts (HP:0002314)2.69933586
33Epileptiform EEG discharges (HP:0011182)2.69376961
34Congenital primary aphakia (HP:0007707)2.67036502
35Neuroendocrine neoplasm (HP:0100634)2.60121383
36Poor eye contact (HP:0000817)2.60020492
37Impaired vibration sensation in the lower limbs (HP:0002166)2.59838686
38EEG with generalized epileptiform discharges (HP:0011198)2.59472083
39Insidious onset (HP:0003587)2.59208508
40Termporal pattern (HP:0011008)2.59208508
41Urinary bladder sphincter dysfunction (HP:0002839)2.58818099
42Medial flaring of the eyebrow (HP:0010747)2.58800317
43Abnormality of macular pigmentation (HP:0008002)2.57026286
44Hemiplegia (HP:0002301)2.51731779
45Gaze-evoked nystagmus (HP:0000640)2.51691242
46Hemiparesis (HP:0001269)2.51406754
47Nephrogenic diabetes insipidus (HP:0009806)2.44051953
48* Anxiety (HP:0000739)2.41927576
49Progressive inability to walk (HP:0002505)2.41345601
50Split foot (HP:0001839)2.39933182
51Impaired social interactions (HP:0000735)2.39549712
52Abnormal social behavior (HP:0012433)2.39549712
53* Depression (HP:0000716)2.39169666
54Cerebral inclusion bodies (HP:0100314)2.38671952
55Hypsarrhythmia (HP:0002521)2.36797228
56Abnormality of the corticospinal tract (HP:0002492)2.34671713
57Scotoma (HP:0000575)2.32240690
58Urinary urgency (HP:0000012)2.31081730
59Specific learning disability (HP:0001328)2.30714558
60Failure to thrive in infancy (HP:0001531)2.29494449
61Torticollis (HP:0000473)2.29366318
62Intention tremor (HP:0002080)2.27751791
63Neurofibrillary tangles (HP:0002185)2.26449744
64Inability to walk (HP:0002540)2.26339618
65Genetic anticipation (HP:0003743)2.25490149
66Sleep apnea (HP:0010535)2.23495324
67Fetal akinesia sequence (HP:0001989)2.23283504
68Genital tract atresia (HP:0001827)2.22723404
69Spastic tetraplegia (HP:0002510)2.22463231
70Bony spicule pigmentary retinopathy (HP:0007737)2.21372677
71Morphological abnormality of the pyramidal tract (HP:0002062)2.21113305
72Spastic gait (HP:0002064)2.20757249
73Megalencephaly (HP:0001355)2.18701328
74Vaginal atresia (HP:0000148)2.17433542
75Absent speech (HP:0001344)2.14539874
76Hypoventilation (HP:0002791)2.14477831
77Abnormal rod and cone electroretinograms (HP:0008323)2.12852628
78Bradykinesia (HP:0002067)2.12589163
79Postural instability (HP:0002172)2.11588272
80Focal dystonia (HP:0004373)2.10054319
81Abnormal hair whorl (HP:0010721)2.05157476
82Poor suck (HP:0002033)2.04509528
83Protruding tongue (HP:0010808)2.03959880
84Hypoplasia of the brainstem (HP:0002365)2.03862480
85Aplasia/Hypoplasia of the brainstem (HP:0007362)2.03862480
86Nephronophthisis (HP:0000090)2.03089368
87* Dysmetria (HP:0001310)2.02839108
88* Dysdiadochokinesis (HP:0002075)2.02261421
89Pancreatic fibrosis (HP:0100732)2.00048200
90Hypothermia (HP:0002045)1.99554450
91True hermaphroditism (HP:0010459)1.99286281
92Lower limb muscle weakness (HP:0007340)1.97148163
93Craniofacial dystonia (HP:0012179)1.96392380
94Agitation (HP:0000713)1.96159322
95Akinesia (HP:0002304)1.94795877
96Oligodactyly (hands) (HP:0001180)1.93672944
97Generalized myoclonic seizures (HP:0002123)1.92817619
98Esotropia (HP:0000565)1.92155521
99Scanning speech (HP:0002168)1.91976310
100* Action tremor (HP:0002345)1.90181520
101Lissencephaly (HP:0001339)1.89588054
102Decreased central vision (HP:0007663)1.88739360
103Poor coordination (HP:0002370)1.88241307
104Molar tooth sign on MRI (HP:0002419)1.87625653
105Abnormality of midbrain morphology (HP:0002418)1.87625653
106Hyperthyroidism (HP:0000836)1.87175867
107Stereotypic behavior (HP:0000733)1.86666365
108Retinal dysplasia (HP:0007973)1.86645869
109Optic nerve hypoplasia (HP:0000609)1.86624797
110Abnormality of salivation (HP:0100755)1.85820497
111Type II lissencephaly (HP:0007260)1.85330779
112Impaired smooth pursuit (HP:0007772)1.85185951
113Cerebral hypomyelination (HP:0006808)1.84991763
114Status epilepticus (HP:0002133)1.84641797
115Incomplete penetrance (HP:0003829)1.82807541
116Pancreatic cysts (HP:0001737)1.81606118
117Impaired vibratory sensation (HP:0002495)1.81300499
118Abnormality of the lower motor neuron (HP:0002366)1.81048886
119Blue irides (HP:0000635)1.80164939
120Amyotrophic lateral sclerosis (HP:0007354)1.79355055
121Impaired pain sensation (HP:0007328)1.79236695
122Pachygyria (HP:0001302)1.77002736
123Spastic tetraparesis (HP:0001285)1.76350249
124Hypoplasia of the corpus callosum (HP:0002079)1.73287082
125Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.68983680
126Muscular hypotonia of the trunk (HP:0008936)1.68488175

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK14.00780188
2CASK3.82041148
3NTRK33.79536217
4EPHA43.43590226
5MAP3K43.30810193
6MAP3K93.27326016
7MAP2K73.12024613
8MINK12.81867267
9MAP3K122.70436340
10NTRK22.21446840
11DAPK22.00844018
12MAP2K41.94250858
13FRK1.92370241
14PAK61.89328807
15PLK21.81282900
16MAPK131.76944298
17GRK51.75957046
18PHKG11.75429499
19PHKG21.75429499
20NTRK11.64384673
21RIPK41.61701769
22KSR11.48166358
23KSR21.47469222
24PNCK1.45974804
25TNIK1.43488264
26CDK51.41422305
27DAPK11.39208053
28PRPF4B1.38083326
29PRKCG1.26155671
30CDK191.20892409
31SIK21.20110745
32ARAF1.17901442
33LMTK21.17586718
34TRIM281.17506332
35CAMKK11.16002037
36MAP4K21.13409239
37NME11.10775474
38SIK31.09239418
39TAOK11.04918362
40CAMK2A1.04798776
41UHMK11.01015865
42PRKD30.99099983
43CCNB10.98365629
44LATS20.96643185
45SGK2230.95986466
46SGK4940.95986466
47PKN10.95811558
48FGFR20.95434847
49CSNK1A1L0.94580612
50CDK180.93051402
51FES0.91842932
52CSNK1G10.91782162
53CDK140.91557164
54DYRK1A0.89955826
55BMPR1B0.87261497
56CDK150.86544238
57CSNK1G20.81574239
58STK380.79914937
59CAMKK20.76605003
60TAOK20.76470899
61DYRK20.76384533
62GRK70.75233929
63PAK30.74990421
64SGK20.74486275
65CDK11A0.73932703
66BMPR20.71195379
67CAMK2B0.70754173
68BCR0.70700548
69RET0.69422197
70OXSR10.68695725
71PRKCE0.67628432
72ADRBK10.66989252
73INSRR0.66843295
74MAP3K20.66605800
75MKNK20.64649803
76TYRO30.62318106
77PTK2B0.61067146
78MAPK150.60886835
79PRKCZ0.60535632
80AKT30.57841162
81WNK30.57837423
82PINK10.56682108
83STK110.55637671
84FGR0.55510832
85LIMK10.54013389
86CAMK40.53748929
87MAP3K130.52221075
88SGK10.52214160
89CSNK1D0.51473332
90FER0.51185307
91TSSK60.51100008
92NEK10.50848330
93CAMK10.50041659
94MAP2K10.49428059
95CAMK2D0.48302372
96PRKG10.47860107
97MARK20.47622265
98NEK60.47042103
99PDK40.46904882
100PDK30.46904882
101GRK10.45611576
102CSNK1A10.43933697
103ERBB30.43796134
104MAPK100.43121192
105MAP3K10.42053524
106CSNK1G30.42008565
107MAPK120.41941125
108TNK20.41913254
109WNK40.41884085
110RAF10.40053432
111SGK30.39590757
112CSNK1E0.39479158
113CAMK2G0.39268575
114MAP3K60.38196862
115PRKCH0.37893713
116ROCK20.37773808
117PRKCA0.37562138
118PRKACB0.36548563
119RPS6KA30.36523856
120PRKACA0.35516191
121STK390.35354017
122ERBB20.35298160
123RPS6KA20.35288556
124PRKCB0.35066053
125ADRBK20.34345974
126PLK30.34291876
127BRAF0.33950605
128FYN0.33341756
129MAP3K110.33100793
130ZAK0.32926329
131ALK0.32422228

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.92588233
2Synaptic vesicle cycle_Homo sapiens_hsa047213.82159454
3Phototransduction_Homo sapiens_hsa047442.82214681
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.75752553
5GABAergic synapse_Homo sapiens_hsa047272.73539863
6Olfactory transduction_Homo sapiens_hsa047402.65317307
7Circadian entrainment_Homo sapiens_hsa047132.52242714
8Morphine addiction_Homo sapiens_hsa050322.45127635
9Glutamatergic synapse_Homo sapiens_hsa047242.38506072
10Collecting duct acid secretion_Homo sapiens_hsa049662.28485557
11Long-term potentiation_Homo sapiens_hsa047202.23782608
12Amphetamine addiction_Homo sapiens_hsa050312.18187480
13* Dopaminergic synapse_Homo sapiens_hsa047282.17660129
14Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.15240124
15Salivary secretion_Homo sapiens_hsa049701.99433495
16Cholinergic synapse_Homo sapiens_hsa047251.93897998
17Insulin secretion_Homo sapiens_hsa049111.92647156
18Serotonergic synapse_Homo sapiens_hsa047261.89831883
19Taste transduction_Homo sapiens_hsa047421.88551807
20Renin secretion_Homo sapiens_hsa049241.69461485
21Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.65177555
22Gastric acid secretion_Homo sapiens_hsa049711.60055183
23Long-term depression_Homo sapiens_hsa047301.57742211
24Cocaine addiction_Homo sapiens_hsa050301.55731631
25Aldosterone synthesis and secretion_Homo sapiens_hsa049251.51810190
26Oxytocin signaling pathway_Homo sapiens_hsa049211.48099418
27Calcium signaling pathway_Homo sapiens_hsa040201.45620635
28* Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.44853377
29Vibrio cholerae infection_Homo sapiens_hsa051101.37754703
30Gap junction_Homo sapiens_hsa045401.32717933
31GnRH signaling pathway_Homo sapiens_hsa049121.31806798
32Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.30959730
33Oxidative phosphorylation_Homo sapiens_hsa001901.30383671
34Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.29301981
35Cardiac muscle contraction_Homo sapiens_hsa042601.25352727
36Butanoate metabolism_Homo sapiens_hsa006501.25126021
37Axon guidance_Homo sapiens_hsa043601.23600303
38Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.19227161
39Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.13679438
40Alzheimers disease_Homo sapiens_hsa050101.03555394
41Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.03431786
42Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.03381031
43cAMP signaling pathway_Homo sapiens_hsa040241.03044188
44Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.02582308
45Parkinsons disease_Homo sapiens_hsa050120.98118383
46Estrogen signaling pathway_Homo sapiens_hsa049150.95793843
47Phosphatidylinositol signaling system_Homo sapiens_hsa040700.93204430
48cGMP-PKG signaling pathway_Homo sapiens_hsa040220.93191473
49Melanogenesis_Homo sapiens_hsa049160.91273081
50Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.91177893
51Type II diabetes mellitus_Homo sapiens_hsa049300.90401883
52ErbB signaling pathway_Homo sapiens_hsa040120.87440484
53Glioma_Homo sapiens_hsa052140.87355770
54Vitamin B6 metabolism_Homo sapiens_hsa007500.85705490
55Vascular smooth muscle contraction_Homo sapiens_hsa042700.77833652
56Nitrogen metabolism_Homo sapiens_hsa009100.77214757
57Ether lipid metabolism_Homo sapiens_hsa005650.75159581
58beta-Alanine metabolism_Homo sapiens_hsa004100.74897798
59Oocyte meiosis_Homo sapiens_hsa041140.73949531
60Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.72403765
61Pancreatic secretion_Homo sapiens_hsa049720.65391623
62Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.65333243
63Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.64744769
64Huntingtons disease_Homo sapiens_hsa050160.64265166
65Steroid biosynthesis_Homo sapiens_hsa001000.61550093
66Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.60331344
67Phospholipase D signaling pathway_Homo sapiens_hsa040720.58689374
68Histidine metabolism_Homo sapiens_hsa003400.58541762
69Bile secretion_Homo sapiens_hsa049760.58389724
70Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.57952347
71MAPK signaling pathway_Homo sapiens_hsa040100.56988424
72Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.56706965
73Protein export_Homo sapiens_hsa030600.55562187
74Glucagon signaling pathway_Homo sapiens_hsa049220.55557223
75Choline metabolism in cancer_Homo sapiens_hsa052310.55102299
76Dilated cardiomyopathy_Homo sapiens_hsa054140.55022252
77Dorso-ventral axis formation_Homo sapiens_hsa043200.54880491
78Thyroid hormone synthesis_Homo sapiens_hsa049180.54423143
79Circadian rhythm_Homo sapiens_hsa047100.54332435
80Alcoholism_Homo sapiens_hsa050340.54229533
81Propanoate metabolism_Homo sapiens_hsa006400.53104702
82SNARE interactions in vesicular transport_Homo sapiens_hsa041300.51939386
83Ras signaling pathway_Homo sapiens_hsa040140.51755645
84Rheumatoid arthritis_Homo sapiens_hsa053230.50887769
85Carbohydrate digestion and absorption_Homo sapiens_hsa049730.50098046
86Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.49816424
87Linoleic acid metabolism_Homo sapiens_hsa005910.49061012
88Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.48103505
89Neurotrophin signaling pathway_Homo sapiens_hsa047220.46739657
90Regulation of autophagy_Homo sapiens_hsa041400.45886205
91Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.45543010
92Endometrial cancer_Homo sapiens_hsa052130.44867740
93VEGF signaling pathway_Homo sapiens_hsa043700.43799167
94Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.42838152
95* Sphingolipid signaling pathway_Homo sapiens_hsa040710.42739030
96Phagosome_Homo sapiens_hsa041450.42641306
97Inositol phosphate metabolism_Homo sapiens_hsa005620.41790642
98alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.41552042
99Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.40356444
100Arginine and proline metabolism_Homo sapiens_hsa003300.39288511
101Wnt signaling pathway_Homo sapiens_hsa043100.38478056
102Thyroid hormone signaling pathway_Homo sapiens_hsa049190.38300060
103Tryptophan metabolism_Homo sapiens_hsa003800.38197722
104Rap1 signaling pathway_Homo sapiens_hsa040150.38187010
105Type I diabetes mellitus_Homo sapiens_hsa049400.37631696
106African trypanosomiasis_Homo sapiens_hsa051430.37356240
107Insulin signaling pathway_Homo sapiens_hsa049100.37298721
108Renal cell carcinoma_Homo sapiens_hsa052110.36144633
109Colorectal cancer_Homo sapiens_hsa052100.35932913
110Hedgehog signaling pathway_Homo sapiens_hsa043400.35250324
111Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.34303019
112Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.33951543
113Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.32751087
114Prion diseases_Homo sapiens_hsa050200.32412624
115* Hippo signaling pathway_Homo sapiens_hsa043900.31399713
116mTOR signaling pathway_Homo sapiens_hsa041500.31287297
117Ovarian steroidogenesis_Homo sapiens_hsa049130.29876087
118Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.29659048
119Primary bile acid biosynthesis_Homo sapiens_hsa001200.28259245
120Endocytosis_Homo sapiens_hsa041440.27915646
121Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.27651429
122Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.27583301
123Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.27246083
124Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.24933882

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »