PPP2R2C

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The product of this gene belongs to the phosphatase 2 regulatory subunit B family. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a gamma isoform of the regulatory subunit B55 subfamily. Alternatively spliced transcript variants encoding different isoforms have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)6.18791648
2regulation of short-term neuronal synaptic plasticity (GO:0048172)6.06023553
3locomotory exploration behavior (GO:0035641)5.89072401
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.66785323
5positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.44792230
6synaptic vesicle exocytosis (GO:0016079)5.33535719
7vocalization behavior (GO:0071625)5.30569819
8glutamate secretion (GO:0014047)5.19143958
9regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.18619109
10regulation of synaptic vesicle exocytosis (GO:2000300)5.00043747
11regulation of glutamate receptor signaling pathway (GO:1900449)4.79198472
12neuronal action potential propagation (GO:0019227)4.76997348
13synaptic vesicle docking involved in exocytosis (GO:0016081)4.69680586
14protein localization to synapse (GO:0035418)4.67472084
15regulation of neuronal synaptic plasticity (GO:0048168)4.59368029
16ionotropic glutamate receptor signaling pathway (GO:0035235)4.54968816
17exploration behavior (GO:0035640)4.51342507
18layer formation in cerebral cortex (GO:0021819)4.51079331
19regulation of long-term neuronal synaptic plasticity (GO:0048169)4.50997034
20regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)4.47345016
21neuron cell-cell adhesion (GO:0007158)4.45477709
22amino acid import (GO:0043090)4.42777536
23regulation of synaptic vesicle transport (GO:1902803)4.40348610
24dendritic spine morphogenesis (GO:0060997)4.38392014
25regulation of synapse structural plasticity (GO:0051823)4.35164250
26neurotransmitter secretion (GO:0007269)4.32986324
27potassium ion homeostasis (GO:0055075)4.23951505
28synaptic transmission, glutamatergic (GO:0035249)4.13245379
29glutamate receptor signaling pathway (GO:0007215)4.03366044
30potassium ion import (GO:0010107)3.99536616
31negative regulation of dendrite morphogenesis (GO:0050774)3.98835619
32neurotransmitter-gated ion channel clustering (GO:0072578)3.97427022
33gamma-aminobutyric acid transport (GO:0015812)3.96556050
34neuron-neuron synaptic transmission (GO:0007270)3.94734272
35long-term memory (GO:0007616)3.92598240
36axon ensheathment in central nervous system (GO:0032291)3.88135447
37central nervous system myelination (GO:0022010)3.88135447
38cell communication by electrical coupling (GO:0010644)3.87901150
39regulation of excitatory postsynaptic membrane potential (GO:0060079)3.84026622
40positive regulation of membrane potential (GO:0045838)3.82935485
41regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.79389872
42regulation of synapse maturation (GO:0090128)3.78638309
43membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.78632435
44regulation of dendritic spine morphogenesis (GO:0061001)3.77712610
45cellular potassium ion homeostasis (GO:0030007)3.77125076
46regulation of ARF protein signal transduction (GO:0032012)3.77053964
47proline transport (GO:0015824)3.73289458
48cellular sodium ion homeostasis (GO:0006883)3.69913973
49transmission of nerve impulse (GO:0019226)3.69549350
50neuromuscular process controlling balance (GO:0050885)3.64184884
51regulation of synaptic plasticity (GO:0048167)3.61888703
52neuron recognition (GO:0008038)3.61664348
53positive regulation of dendritic spine morphogenesis (GO:0061003)3.61205654
54regulation of postsynaptic membrane potential (GO:0060078)3.61035532
55neurotransmitter transport (GO:0006836)3.58375530
56auditory behavior (GO:0031223)3.49845662
57positive regulation of synapse maturation (GO:0090129)3.49125925
58regulation of neurotransmitter secretion (GO:0046928)3.46090786
59activation of protein kinase A activity (GO:0034199)3.44498856
60sodium ion export (GO:0071436)3.42705077
61axonal fasciculation (GO:0007413)3.42186076
62neuronal ion channel clustering (GO:0045161)3.39307140
63synaptic vesicle endocytosis (GO:0048488)3.36335497
64glycine transport (GO:0015816)3.36102886
65cytoskeletal anchoring at plasma membrane (GO:0007016)3.35516424
66dendrite morphogenesis (GO:0048813)3.35357153
67L-amino acid import (GO:0043092)3.35131398
68positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.34621725
69regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.32899948
70long-term synaptic potentiation (GO:0060291)3.32662922
71regulation of neurotransmitter levels (GO:0001505)3.31905325
72cell communication involved in cardiac conduction (GO:0086065)3.30350727
73prepulse inhibition (GO:0060134)3.29946208
74regulation of synaptic transmission, glutamatergic (GO:0051966)3.28776682
75gamma-aminobutyric acid signaling pathway (GO:0007214)3.28115080
76neurotransmitter uptake (GO:0001504)3.28014602
77regulation of neurotransmitter transport (GO:0051588)3.24585029
78response to auditory stimulus (GO:0010996)3.24542446
79positive regulation of synaptic transmission, GABAergic (GO:0032230)3.23611684
80cerebellar Purkinje cell differentiation (GO:0021702)3.22633394
81vesicle docking involved in exocytosis (GO:0006904)3.22451796
82cerebellar granule cell differentiation (GO:0021707)3.21629901
83neuromuscular process controlling posture (GO:0050884)3.21594936
84regulation of dendritic spine development (GO:0060998)3.21174419
85adult walking behavior (GO:0007628)3.21160381
86acidic amino acid transport (GO:0015800)3.19215396
87regulation of vesicle fusion (GO:0031338)3.17727802
88positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.14811939
89negative regulation of synaptic transmission, GABAergic (GO:0032229)3.14546879
90positive regulation of dendritic spine development (GO:0060999)3.14470864
91membrane depolarization (GO:0051899)3.14258831
92presynaptic membrane organization (GO:0097090)3.13901056
93dendritic spine organization (GO:0097061)3.13840003
94chemosensory behavior (GO:0007635)3.12573504
95positive regulation of neurotransmitter transport (GO:0051590)3.12343069
96positive regulation of neurotransmitter secretion (GO:0001956)3.12261659
97membrane hyperpolarization (GO:0060081)3.12198451
98mating behavior (GO:0007617)3.10050470
99detection of calcium ion (GO:0005513)3.09470536
100neuromuscular synaptic transmission (GO:0007274)3.09340277
101establishment of synaptic vesicle localization (GO:0097480)3.09016679
102synaptic vesicle transport (GO:0048489)3.09016679
103regulation of voltage-gated calcium channel activity (GO:1901385)3.07663562
104negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.07481070
105postsynaptic membrane organization (GO:0001941)3.06971993
106vesicle transport along microtubule (GO:0047496)3.06610056
107cell differentiation in hindbrain (GO:0021533)3.05932436
108learning (GO:0007612)3.05731546
109serotonin metabolic process (GO:0042428)3.05467419
110regulation of exocytosis (GO:0017157)3.05462088
111presynaptic membrane assembly (GO:0097105)3.02491950
112membrane depolarization during action potential (GO:0086010)3.02119432
113regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.01856440
114vesicle docking (GO:0048278)3.00052599
115G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.99961425
116G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.99245490
117neuromuscular process (GO:0050905)2.98994747
118cell migration in hindbrain (GO:0021535)2.98849943
119regulation of synaptic transmission (GO:0050804)2.98777087
120positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.98052541
121synapse assembly (GO:0007416)2.95785069
122cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.92956534
123positive regulation of synaptic transmission (GO:0050806)2.92546918
124behavioral response to cocaine (GO:0048148)2.91737108
125organelle transport along microtubule (GO:0072384)2.90457308
126synaptic transmission (GO:0007268)2.88621481

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.81234320
2GBX2_23144817_ChIP-Seq_PC3_Human3.22726766
3* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.15672276
4* JARID2_20064375_ChIP-Seq_MESCs_Mouse3.10760134
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.08180762
6* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.78935200
7* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.78935200
8* RARB_27405468_Chip-Seq_BRAIN_Mouse2.78331793
9* REST_21632747_ChIP-Seq_MESCs_Mouse2.77918217
10* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.65483854
11DROSHA_22980978_ChIP-Seq_HELA_Human2.61946859
12* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.59705206
13* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.58246541
14* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.58027389
15* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.49239521
16SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.48867586
17* EZH2_27304074_Chip-Seq_ESCs_Mouse2.48110470
18SUZ12_27294783_Chip-Seq_ESCs_Mouse2.35084574
19* EZH2_27294783_Chip-Seq_ESCs_Mouse2.32618687
20THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.32014982
21RNF2_27304074_Chip-Seq_ESCs_Mouse2.26662838
22* REST_18959480_ChIP-ChIP_MESCs_Mouse2.26588508
23EED_16625203_ChIP-ChIP_MESCs_Mouse2.23500598
24MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.13470284
25IKZF1_21737484_ChIP-ChIP_HCT116_Human2.03865020
26EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.01627023
27ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.00275792
28NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.91708665
29CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.88763829
30AR_21572438_ChIP-Seq_LNCaP_Human1.87793514
31ERG_21242973_ChIP-ChIP_JURKAT_Human1.70374047
32GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.64934911
33CTBP2_25329375_ChIP-Seq_LNCAP_Human1.59847752
34SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.53475381
35TAF15_26573619_Chip-Seq_HEK293_Human1.52660640
36* ESR2_21235772_ChIP-Seq_MCF-7_Human1.51440095
37CTBP1_25329375_ChIP-Seq_LNCAP_Human1.48889232
38SMAD4_21799915_ChIP-Seq_A2780_Human1.48350932
39RING1B_27294783_Chip-Seq_ESCs_Mouse1.37471849
40* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.35932518
41DNAJC2_21179169_ChIP-ChIP_NT2_Human1.31322026
42PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.30703282
43SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.29597586
44SOX2_21211035_ChIP-Seq_LN229_Gbm1.26823308
45* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.26102570
46NR3C1_23031785_ChIP-Seq_PC12_Mouse1.23942601
47SMAD3_21741376_ChIP-Seq_EPCs_Human1.23006238
48WT1_25993318_ChIP-Seq_PODOCYTE_Human1.22653331
49ZFP57_27257070_Chip-Seq_ESCs_Mouse1.21479247
50RING1B_27294783_Chip-Seq_NPCs_Mouse1.21422593
51* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.20217040
52* KDM2B_26808549_Chip-Seq_K562_Human1.19876138
53* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.19744999
54ZNF274_21170338_ChIP-Seq_K562_Hela1.19607823
55OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.19039098
56STAT3_23295773_ChIP-Seq_U87_Human1.17881839
57P53_22127205_ChIP-Seq_FIBROBLAST_Human1.16174402
58P300_19829295_ChIP-Seq_ESCs_Human1.16144301
59* AR_19668381_ChIP-Seq_PC3_Human1.15879901
60* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.14406805
61CBX2_27304074_Chip-Seq_ESCs_Mouse1.13390474
62SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.11552585
63TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.11028464
64AR_25329375_ChIP-Seq_VCAP_Human1.10601294
65ZFP281_18757296_ChIP-ChIP_E14_Mouse1.09565567
66* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.07609474
67TOP2B_26459242_ChIP-Seq_MCF-7_Human1.07114268
68SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.05239141
69CDX2_19796622_ChIP-Seq_MESCs_Mouse1.05072080
70TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.05003863
71BMI1_23680149_ChIP-Seq_NPCS_Mouse1.04812403
72OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.04242332
73CTNNB1_20460455_ChIP-Seq_HCT116_Human1.04095176
74ZNF217_24962896_ChIP-Seq_MCF-7_Human1.02702757
75SMAD_19615063_ChIP-ChIP_OVARY_Human1.02318575
76RNF2_27304074_Chip-Seq_NSC_Mouse1.01812546
77ESR1_21235772_ChIP-Seq_MCF-7_Human1.01651669
78* TCF4_23295773_ChIP-Seq_U87_Human1.00961705
79SRY_22984422_ChIP-ChIP_TESTIS_Rat1.00879819
80ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.00748503
81MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.99909483
82GATA1_26923725_Chip-Seq_HPCs_Mouse0.99727023
83PIAS1_25552417_ChIP-Seq_VCAP_Human0.99719819
84ARNT_22903824_ChIP-Seq_MCF-7_Human0.99520443
85TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.99271504
86YAP1_20516196_ChIP-Seq_MESCs_Mouse0.99257924
87GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98099557
88VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.96746956
89AHR_22903824_ChIP-Seq_MCF-7_Human0.96570716
90GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95539048
91ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.93790639
92SMAD3_21741376_ChIP-Seq_ESCs_Human0.92884831
93KDM2B_26808549_Chip-Seq_SUP-B15_Human0.92645527
94SMAD4_21741376_ChIP-Seq_HESCs_Human0.92376502
95* LXR_22292898_ChIP-Seq_THP-1_Human0.92113859
96OCT4_19829295_ChIP-Seq_ESCs_Human0.91969386
97TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.91856776
98CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.91578946
99TET1_21490601_ChIP-Seq_MESCs_Mouse0.91215669
100* PRDM14_20953172_ChIP-Seq_ESCs_Human0.90439892
101AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.89858060
102PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.89371025
103SMC4_20622854_ChIP-Seq_HELA_Human0.89151450
104TP53_16413492_ChIP-PET_HCT116_Human0.88971807
105TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88863040
106SMAD3_21741376_ChIP-Seq_HESCs_Human0.88628244
107RUNX2_22187159_ChIP-Seq_PCA_Human0.88439831
108NR3C1_21868756_ChIP-Seq_MCF10A_Human0.88073820
109CTCF_27219007_Chip-Seq_Bcells_Human0.87937959
110DPY_21335234_ChIP-Seq_ESCs_Mouse0.87752416
111IGF1R_20145208_ChIP-Seq_DFB_Human0.84198960
112ZFP281_27345836_Chip-Seq_ESCs_Mouse0.83803023
113* TP53_20018659_ChIP-ChIP_R1E_Mouse0.83326914
114TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.83315440
115POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.83315440
116DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.83157245
117RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.82603918
118* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.82331430
119CREB1_26743006_Chip-Seq_LNCaP_Human0.81998470
120SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.80379976
121* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.79085867
122KLF4_19829295_ChIP-Seq_ESCs_Human0.78513585
123RUNX1_26923725_Chip-Seq_HPCs_Mouse0.78487802
124SMAD4_21741376_ChIP-Seq_ESCs_Human0.76228017
125PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.74617585
126PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.74158547
127MYC_19915707_ChIP-ChIP_AK7_Human0.72677637
128ESR1_20079471_ChIP-ChIP_T-47D_Human0.71797158

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.71200086
2MP0003880_abnormal_central_pattern4.64422220
3MP0003635_abnormal_synaptic_transmissio4.19184426
4MP0004270_analgesia4.09371276
5MP0009745_abnormal_behavioral_response3.44934000
6MP0002063_abnormal_learning/memory/cond3.35037304
7MP0002064_seizures3.23088018
8MP0009046_muscle_twitch3.14051142
9MP0002822_catalepsy3.13957929
10MP0005423_abnormal_somatic_nervous3.06908379
11MP0001968_abnormal_touch/_nociception2.97020086
12MP0002734_abnormal_mechanical_nocicepti2.81824457
13MP0002572_abnormal_emotion/affect_behav2.78529183
14MP0001486_abnormal_startle_reflex2.74584483
15MP0002272_abnormal_nervous_system2.74349267
16MP0002736_abnormal_nociception_after2.24092651
17MP0002735_abnormal_chemical_nociception2.23366671
18MP0001501_abnormal_sleep_pattern2.18311853
19MP0003329_amyloid_beta_deposits2.17489756
20MP0001440_abnormal_grooming_behavior2.15455008
21MP0002733_abnormal_thermal_nociception2.11771768
22MP0008569_lethality_at_weaning2.06311059
23MP0001970_abnormal_pain_threshold2.06251580
24MP0002067_abnormal_sensory_capabilities1.98355986
25MP0000778_abnormal_nervous_system1.97647553
26MP0004858_abnormal_nervous_system1.87933040
27MP0004811_abnormal_neuron_physiology1.82987521
28MP0009780_abnormal_chondrocyte_physiolo1.82580128
29MP0002184_abnormal_innervation1.81075172
30MP0005386_behavior/neurological_phenoty1.80881679
31MP0004924_abnormal_behavior1.80881679
32MP0004885_abnormal_endolymph1.78595068
33MP0003123_paternal_imprinting1.74441278
34MP0002557_abnormal_social/conspecific_i1.71262671
35MP0000955_abnormal_spinal_cord1.71120350
36MP0002909_abnormal_adrenal_gland1.59543507
37MP0001984_abnormal_olfaction1.50791246
38MP0002882_abnormal_neuron_morphology1.50412391
39MP0002066_abnormal_motor_capabilities/c1.50344076
40MP0003633_abnormal_nervous_system1.47646833
41MP0006276_abnormal_autonomic_nervous1.44750233
42MP0000920_abnormal_myelination1.44569755
43MP0001529_abnormal_vocalization1.43019760
44MP0003879_abnormal_hair_cell1.42500567
45MP0004142_abnormal_muscle_tone1.42409457
46MP0005646_abnormal_pituitary_gland1.41576809
47MP0001905_abnormal_dopamine_level1.38041377
48MP0003631_nervous_system_phenotype1.30215634
49MP0000579_abnormal_nail_morphology1.22546465
50MP0003690_abnormal_glial_cell1.20071181
51MP0003787_abnormal_imprinting1.17939365
52MP0002152_abnormal_brain_morphology1.16659714
53MP0004742_abnormal_vestibular_system1.14293885
54MP0005645_abnormal_hypothalamus_physiol1.09301949
55MP0002229_neurodegeneration1.08947341
56MP0001502_abnormal_circadian_rhythm1.08769806
57MP0003634_abnormal_glial_cell1.07170692
58MP0003632_abnormal_nervous_system1.05883589
59MP0001177_atelectasis0.99319857
60MP0008872_abnormal_physiological_respon0.98731410
61MP0000604_amyloidosis0.98541492
62MP0003075_altered_response_to0.94066844
63MP0008874_decreased_physiological_sensi0.94032661
64MP0004145_abnormal_muscle_electrophysio0.93467299
65MP0002069_abnormal_eating/drinking_beha0.91234301
66MP0005409_darkened_coat_color0.89388657
67MP0010234_abnormal_vibrissa_follicle0.88965591
68MP0001346_abnormal_lacrimal_gland0.88955870
69MP0001188_hyperpigmentation0.86217811
70MP0000751_myopathy0.85186033
71MP0004147_increased_porphyrin_level0.84768795
72MP0005551_abnormal_eye_electrophysiolog0.84514586
73MP0001963_abnormal_hearing_physiology0.84191749
74MP0001485_abnormal_pinna_reflex0.82094252
75MP0002752_abnormal_somatic_nervous0.80088599
76MP0003283_abnormal_digestive_organ0.79003309
77MP0005535_abnormal_body_temperature0.78352675
78MP0005499_abnormal_olfactory_system0.77904461
79MP0005394_taste/olfaction_phenotype0.77904461
80MP0004085_abnormal_heartbeat0.77801961
81MP0008877_abnormal_DNA_methylation0.75584849
82MP0003122_maternal_imprinting0.73796882
83MP0002090_abnormal_vision0.72658270
84MP0002638_abnormal_pupillary_reflex0.71632578
85MP0000013_abnormal_adipose_tissue0.70585134
86MP0000631_abnormal_neuroendocrine_gland0.69552404
87MP0005623_abnormal_meninges_morphology0.68021520
88MP0000569_abnormal_digit_pigmentation0.67147258
89MP0001299_abnormal_eye_distance/0.66411478
90MP0003137_abnormal_impulse_conducting0.65908508
91MP0005167_abnormal_blood-brain_barrier0.65487756
92MP0008961_abnormal_basal_metabolism0.62894087
93MP0003861_abnormal_nervous_system0.62011768
94MP0010386_abnormal_urinary_bladder0.61154169
95MP0004043_abnormal_pH_regulation0.59260483
96MP0001986_abnormal_taste_sensitivity0.58635182
97MP0005187_abnormal_penis_morphology0.56701816
98MP0001943_abnormal_respiration0.56635629
99MP0010769_abnormal_survival0.54877147
100MP0004484_altered_response_of0.54698201
101MP0001664_abnormal_digestion0.54688712
102MP0000566_synostosis0.52689620
103MP0002082_postnatal_lethality0.51706838
104MP0010770_preweaning_lethality0.51706838
105MP0010768_mortality/aging0.51384168
106MP0003121_genomic_imprinting0.51120481
107MP0003956_abnormal_body_size0.50206996
108MP0004215_abnormal_myocardial_fiber0.49690166
109MP0003172_abnormal_lysosome_physiology0.49225414
110MP0004130_abnormal_muscle_cell0.49106236
111MP0001348_abnormal_lacrimal_gland0.48739701
112MP0003183_abnormal_peptide_metabolism0.46016118
113MP0000026_abnormal_inner_ear0.45138917
114MP0001731_abnormal_postnatal_growth0.42751225
115MP0001765_abnormal_ion_homeostasis0.42735672

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)7.53425539
2Focal motor seizures (HP:0011153)7.08973157
3Focal seizures (HP:0007359)5.53071140
4Visual hallucinations (HP:0002367)5.02513439
5Epileptic encephalopathy (HP:0200134)4.49127028
6Action tremor (HP:0002345)4.42276792
7Atonic seizures (HP:0010819)4.21963619
8Progressive cerebellar ataxia (HP:0002073)4.20946006
9Ankle clonus (HP:0011448)4.03710374
10Supranuclear gaze palsy (HP:0000605)4.03112071
11Febrile seizures (HP:0002373)3.89478321
12Absence seizures (HP:0002121)3.79419992
13Generalized tonic-clonic seizures (HP:0002069)3.61778517
14Broad-based gait (HP:0002136)3.58775534
15Dialeptic seizures (HP:0011146)3.54407339
16Impaired vibration sensation in the lower limbs (HP:0002166)3.45533278
17Dysmetria (HP:0001310)3.43804848
18Neurofibrillary tangles (HP:0002185)3.42601466
19Gaze-evoked nystagmus (HP:0000640)3.41178577
20Poor eye contact (HP:0000817)3.40680751
21Urinary bladder sphincter dysfunction (HP:0002839)3.30545990
22Dysdiadochokinesis (HP:0002075)3.29350544
23Tetraplegia (HP:0002445)3.28200324
24Cerebral hypomyelination (HP:0006808)3.22940023
25Abnormality of the corticospinal tract (HP:0002492)3.22230956
26Depression (HP:0000716)3.20827901
27Spastic gait (HP:0002064)3.16586748
28Mutism (HP:0002300)3.14640203
29Cerebral inclusion bodies (HP:0100314)3.14575080
30Papilledema (HP:0001085)3.10379639
31Termporal pattern (HP:0011008)3.09525345
32Insidious onset (HP:0003587)3.09525345
33Intention tremor (HP:0002080)3.08651122
34Urinary urgency (HP:0000012)3.08511172
35Impaired social interactions (HP:0000735)3.05589096
36Abnormal social behavior (HP:0012433)3.05589096
37Anxiety (HP:0000739)3.04889744
38Truncal ataxia (HP:0002078)3.00494039
39Scanning speech (HP:0002168)2.95129639
40Postural instability (HP:0002172)2.93765298
41Hyperventilation (HP:0002883)2.84423929
42Abnormal eating behavior (HP:0100738)2.82737211
43Megalencephaly (HP:0001355)2.76937941
44Amblyopia (HP:0000646)2.75003861
45Torticollis (HP:0000473)2.73527947
46Hemiparesis (HP:0001269)2.65922885
47Abnormality of the lower motor neuron (HP:0002366)2.64958498
48Degeneration of the lateral corticospinal tracts (HP:0002314)2.59243143
49Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.59243143
50Progressive inability to walk (HP:0002505)2.59195638
51Genetic anticipation (HP:0003743)2.58917907
52Impaired smooth pursuit (HP:0007772)2.54692683
53Diplopia (HP:0000651)2.51048220
54Abnormality of binocular vision (HP:0011514)2.51048220
55Focal dystonia (HP:0004373)2.50392482
56Drooling (HP:0002307)2.48602236
57Excessive salivation (HP:0003781)2.48602236
58Lower limb muscle weakness (HP:0007340)2.47080788
59Stereotypic behavior (HP:0000733)2.44753263
60Annular pancreas (HP:0001734)2.42756575
61Limb dystonia (HP:0002451)2.42311093
62Sleep apnea (HP:0010535)2.42267043
63Bradykinesia (HP:0002067)2.37878987
64Hemiplegia (HP:0002301)2.34811286
65Diminished motivation (HP:0000745)2.34705130
66Pheochromocytoma (HP:0002666)2.31431518
67Impaired vibratory sensation (HP:0002495)2.30781169
68Clonus (HP:0002169)2.28485365
69Craniofacial dystonia (HP:0012179)2.26302024
70Ventricular fibrillation (HP:0001663)2.25784692
71Abnormality of ocular smooth pursuit (HP:0000617)2.25371843
72Fetal akinesia sequence (HP:0001989)2.24852302
73Epileptiform EEG discharges (HP:0011182)2.21214549
74Obstructive sleep apnea (HP:0002870)2.19230463
75Peripheral hypomyelination (HP:0007182)2.17881153
76EEG with generalized epileptiform discharges (HP:0011198)2.17369919
77Amyotrophic lateral sclerosis (HP:0007354)2.16288335
78Bundle branch block (HP:0011710)2.15031457
79Absent speech (HP:0001344)2.14994712
80Insomnia (HP:0100785)2.13465126
81Generalized myoclonic seizures (HP:0002123)2.10612559
82Choreoathetosis (HP:0001266)2.10468798
83Hypsarrhythmia (HP:0002521)2.10021283
84Dysmetric saccades (HP:0000641)2.07489089
85Neuronal loss in central nervous system (HP:0002529)2.06772973
86CNS hypomyelination (HP:0003429)2.04416826
87Status epilepticus (HP:0002133)2.00462993
88Pointed chin (HP:0000307)1.99838070
89Gait ataxia (HP:0002066)1.97741581
90Inability to walk (HP:0002540)1.97333811
91Abnormality of saccadic eye movements (HP:0000570)1.96548042
92Neuroendocrine neoplasm (HP:0100634)1.94622210
93Akinesia (HP:0002304)1.94257829
94Incomplete penetrance (HP:0003829)1.93289360
95Aplasia involving bones of the upper limbs (HP:0009823)1.91336420
96Aplasia of the phalanges of the hand (HP:0009802)1.91336420
97Aplasia involving bones of the extremities (HP:0009825)1.91336420
98Delusions (HP:0000746)1.87469240
99Agitation (HP:0000713)1.87180987
100Rigidity (HP:0002063)1.86457365
101Apathy (HP:0000741)1.85951141
102Increased circulating renin level (HP:0000848)1.85739055
103Onion bulb formation (HP:0003383)1.83721648
104Spastic tetraparesis (HP:0001285)1.83089757
105Inappropriate behavior (HP:0000719)1.83057048
106Morphological abnormality of the pyramidal tract (HP:0002062)1.82981830
107Bronchomalacia (HP:0002780)1.82850485
108Rapidly progressive (HP:0003678)1.82365927
109Polyphagia (HP:0002591)1.81278144
110Resting tremor (HP:0002322)1.81203625
111Spinal canal stenosis (HP:0003416)1.80578832
112Lower limb asymmetry (HP:0100559)1.80233268
113Lower limb amyotrophy (HP:0007210)1.78517381
114Heart block (HP:0012722)1.73400922

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA44.36099859
2NTRK34.05521604
3MAP3K93.86300853
4MARK13.34716715
5DAPK22.72981875
6MAP3K42.72602396
7MINK12.64921594
8PAK62.48125367
9KSR22.31935000
10NTRK12.17913382
11PRKD32.13861940
12MAP2K72.13544723
13NTRK22.03272514
14CAMKK11.97480744
15RIPK41.75568968
16MAP2K41.66601937
17PNCK1.64127110
18CDK51.61909892
19CDK191.56791170
20TNIK1.51044450
21KSR11.49067588
22PRPF4B1.43659419
23TYRO31.40658592
24UHMK11.38213165
25GRK51.36554084
26DAPK11.36406362
27MAP3K121.31724496
28CASK1.30688440
29MAP3K21.29937928
30OXSR11.28006806
31ARAF1.27753644
32PLK21.26324167
33MAPK131.24527936
34SIK21.19443196
35CAMKK21.17913925
36STK381.15273404
37PRKCG1.13448760
38PHKG21.11322310
39PHKG11.11322310
40MAP3K131.07253493
41FES1.06034835
42STK111.02644579
43STK391.01483089
44CDK151.00376111
45CDK180.99253651
46TAOK10.99233961
47SGK4940.99125333
48SGK2230.99125333
49CDK140.98372214
50CAMK2A0.95771924
51CAMK10.89100433
52PINK10.88914318
53RET0.88364537
54CDK11A0.88254687
55ALK0.87125724
56LATS20.86908469
57CSNK1G20.86582830
58CAMK2B0.86468115
59PRKCH0.82979521
60MARK20.79518144
61PAK30.78760608
62MAPK120.77266409
63RAF10.75042706
64WNK10.74349226
65PDPK10.69461333
66PDK10.68963979
67PTK2B0.65660903
68MAPKAPK50.65287324
69BMPR20.65124611
70SGK10.64177338
71DYRK1A0.63758499
72TESK10.62893997
73LMTK20.62406164
74FGFR20.60870788
75BRAF0.58870061
76NEK60.56831399
77PKN10.55647006
78PRKCZ0.52954297
79FGR0.52851356
80MAP3K10.52478061
81CAMK2D0.51643707
82CAMK2G0.51396274
83FYN0.51104348
84CAMK1G0.50795806
85RIPK10.50744771
86SGK20.50712421
87SGK30.49864946
88RPS6KA30.48028256
89ROCK20.45799513
90MAPK100.45494071
91PRKCE0.45276548
92DAPK30.44368611
93SCYL20.43566165
94TNK20.43549439
95MAP3K110.42148361
96BCR0.41809255
97BRSK10.41576650
98LIMK10.40415876
99CSNK1G30.40363102
100CAMK40.39413500
101MAP2K10.39387207
102ICK0.38755709
103CDC42BPA0.38063322
104TRIB30.35567919
105MAP3K70.33558808
106IRAK20.33178306
107PRKCA0.32220132
108MAP2K60.28592810
109RPS6KB10.28448327
110MAPK80.27906647
111CSNK1D0.27428460
112CSNK1E0.27323647
113CCNB10.25933245

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.38186660
2Synaptic vesicle cycle_Homo sapiens_hsa047213.19750591
3Olfactory transduction_Homo sapiens_hsa047402.88960377
4GABAergic synapse_Homo sapiens_hsa047272.68592159
5Glutamatergic synapse_Homo sapiens_hsa047242.67871735
6Circadian entrainment_Homo sapiens_hsa047132.67029922
7Long-term potentiation_Homo sapiens_hsa047202.63448720
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.60967040
9Morphine addiction_Homo sapiens_hsa050322.50380750
10Amphetamine addiction_Homo sapiens_hsa050312.41377003
11Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.21845511
12Salivary secretion_Homo sapiens_hsa049702.18230851
13* Dopaminergic synapse_Homo sapiens_hsa047282.14656784
14Cholinergic synapse_Homo sapiens_hsa047251.98818250
15Gastric acid secretion_Homo sapiens_hsa049711.96970569
16Insulin secretion_Homo sapiens_hsa049111.90454438
17Aldosterone synthesis and secretion_Homo sapiens_hsa049251.80173689
18Long-term depression_Homo sapiens_hsa047301.78286632
19Cocaine addiction_Homo sapiens_hsa050301.69443058
20Renin secretion_Homo sapiens_hsa049241.67942673
21Serotonergic synapse_Homo sapiens_hsa047261.67863163
22Oxytocin signaling pathway_Homo sapiens_hsa049211.67060432
23Taste transduction_Homo sapiens_hsa047421.66161401
24* Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.65576537
25Vitamin B6 metabolism_Homo sapiens_hsa007501.61188065
26Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.52000310
27Calcium signaling pathway_Homo sapiens_hsa040201.50704335
28GnRH signaling pathway_Homo sapiens_hsa049121.50095495
29Gap junction_Homo sapiens_hsa045401.42248607
30Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.39974713
31Nitrogen metabolism_Homo sapiens_hsa009101.39765994
32Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.37823515
33Axon guidance_Homo sapiens_hsa043601.27917585
34cAMP signaling pathway_Homo sapiens_hsa040241.25109343
35Collecting duct acid secretion_Homo sapiens_hsa049661.21917422
36Estrogen signaling pathway_Homo sapiens_hsa049151.18215870
37Glioma_Homo sapiens_hsa052141.18015648
38Phosphatidylinositol signaling system_Homo sapiens_hsa040701.16640771
39Type II diabetes mellitus_Homo sapiens_hsa049301.14688098
40ErbB signaling pathway_Homo sapiens_hsa040121.10861151
41Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.09711736
42Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.05432169
43Melanogenesis_Homo sapiens_hsa049161.03866912
44cGMP-PKG signaling pathway_Homo sapiens_hsa040221.00469572
45Phospholipase D signaling pathway_Homo sapiens_hsa040720.96943314
46Vascular smooth muscle contraction_Homo sapiens_hsa042700.96272015
47Dorso-ventral axis formation_Homo sapiens_hsa043200.95596669
48Cardiac muscle contraction_Homo sapiens_hsa042600.92670966
49Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.91071553
50Oocyte meiosis_Homo sapiens_hsa041140.91038342
51Pancreatic secretion_Homo sapiens_hsa049720.87702635
52Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.83209950
53Choline metabolism in cancer_Homo sapiens_hsa052310.78251241
54Vibrio cholerae infection_Homo sapiens_hsa051100.78211756
55Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.78054742
56Thyroid hormone synthesis_Homo sapiens_hsa049180.77561094
57Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.74017702
58Phototransduction_Homo sapiens_hsa047440.73243616
59VEGF signaling pathway_Homo sapiens_hsa043700.71971283
60MAPK signaling pathway_Homo sapiens_hsa040100.71833162
61Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.70667909
62Neurotrophin signaling pathway_Homo sapiens_hsa047220.66113559
63Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.66066779
64Dilated cardiomyopathy_Homo sapiens_hsa054140.65432623
65Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.64904746
66Ras signaling pathway_Homo sapiens_hsa040140.63991399
67* Sphingolipid signaling pathway_Homo sapiens_hsa040710.62269816
68Endocytosis_Homo sapiens_hsa041440.61910549
69Carbohydrate digestion and absorption_Homo sapiens_hsa049730.61490294
70Rap1 signaling pathway_Homo sapiens_hsa040150.59289638
71Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.57922028
72Renal cell carcinoma_Homo sapiens_hsa052110.57810981
73Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.57542937
74Alcoholism_Homo sapiens_hsa050340.55404311
75Bile secretion_Homo sapiens_hsa049760.51645878
76Circadian rhythm_Homo sapiens_hsa047100.50877726
77mTOR signaling pathway_Homo sapiens_hsa041500.50103429
78Inositol phosphate metabolism_Homo sapiens_hsa005620.49189315
79Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.48047512
80Non-small cell lung cancer_Homo sapiens_hsa052230.47986446
81Thyroid hormone signaling pathway_Homo sapiens_hsa049190.47907093
82Prion diseases_Homo sapiens_hsa050200.45774667
83Endometrial cancer_Homo sapiens_hsa052130.44816559
84Arginine and proline metabolism_Homo sapiens_hsa003300.43397555
85Glucagon signaling pathway_Homo sapiens_hsa049220.42440838
86Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.42174860
87Wnt signaling pathway_Homo sapiens_hsa043100.41977689
88Ovarian steroidogenesis_Homo sapiens_hsa049130.41483561
89SNARE interactions in vesicular transport_Homo sapiens_hsa041300.41026387
90Histidine metabolism_Homo sapiens_hsa003400.40559566
91Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.40299470
92Fatty acid biosynthesis_Homo sapiens_hsa000610.39828808
93Chemokine signaling pathway_Homo sapiens_hsa040620.39579400
94Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.38827687
95Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.38099219
96Longevity regulating pathway - mammal_Homo sapiens_hsa042110.38049746
97Arginine biosynthesis_Homo sapiens_hsa002200.37889157
98Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.36132323
99Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.34686856
100Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.34595930
101Mineral absorption_Homo sapiens_hsa049780.34568048
102Type I diabetes mellitus_Homo sapiens_hsa049400.34493046
103Insulin signaling pathway_Homo sapiens_hsa049100.33169661
104Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.32509842
105African trypanosomiasis_Homo sapiens_hsa051430.32483582
106Glycerophospholipid metabolism_Homo sapiens_hsa005640.31879302
107Alzheimers disease_Homo sapiens_hsa050100.31479971
108Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.30317531
109Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.28774596
110beta-Alanine metabolism_Homo sapiens_hsa004100.27864381
111* Tight junction_Homo sapiens_hsa045300.22756060
112HIF-1 signaling pathway_Homo sapiens_hsa040660.21517874
113Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.21205726

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