PPP2R3A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes one of the regulatory subunits of the protein phosphatase 2. Protein phosphatase 2 (formerly named type 2A) is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein phosphatase 2 holoenzymes are heterotrimeric proteins composed of a structural subunit A, a catalytic subunit C, and a regulatory subunit B. The regulatory subunit is encoded by a diverse set of genes that have been grouped into the B/PR55, B'/PR61, and B''/PR72 families. These different regulatory subunits confer distinct enzymatic specificities and intracellular localizations to the holozenzyme. The product of this gene belongs to the B'' family. The B'' family has been further divided into subfamilies. The product of this gene belongs to the alpha subfamily of regulatory subunit B''. Alternative splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sarcomere organization (GO:0045214)5.60519388
2cardiac myofibril assembly (GO:0055003)5.42981198
3actin-myosin filament sliding (GO:0033275)5.38412550
4muscle filament sliding (GO:0030049)5.38412550
5negative regulation of potassium ion transmembrane transporter activity (GO:1901017)5.33114834
6myofibril assembly (GO:0030239)5.25415765
7axon ensheathment in central nervous system (GO:0032291)4.90770767
8central nervous system myelination (GO:0022010)4.90770767
9regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)4.85795425
10regulation of skeletal muscle contraction (GO:0014819)4.80064298
11actin-mediated cell contraction (GO:0070252)4.70816106
12regulation of relaxation of muscle (GO:1901077)4.62516057
13negative regulation of potassium ion transmembrane transport (GO:1901380)4.59216754
14negative regulation of protein localization to cell surface (GO:2000009)4.59216348
15positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)4.58698505
16sarcoplasmic reticulum calcium ion transport (GO:0070296)4.55796989
17regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO4.53444060
18regulation of actin filament-based movement (GO:1903115)4.50148340
19regulation of cell communication by electrical coupling (GO:0010649)4.35691711
20response to muscle activity (GO:0014850)4.26950827
21creatine metabolic process (GO:0006600)4.26145816
22response to stimulus involved in regulation of muscle adaptation (GO:0014874)4.18701920
23cardiac muscle contraction (GO:0060048)4.16004190
24regulation of calcineurin-NFAT signaling cascade (GO:0070884)4.14879722
25regulation of sarcomere organization (GO:0060297)4.06614078
26regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)4.00700026
27adult heart development (GO:0007512)3.96686069
28regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.96020705
29myotube cell development (GO:0014904)3.95997120
30skeletal muscle fiber development (GO:0048741)3.90665774
31actomyosin structure organization (GO:0031032)3.88007804
32muscle fiber development (GO:0048747)3.81417021
33cardiac muscle tissue morphogenesis (GO:0055008)3.81201318
34regulation of striated muscle contraction (GO:0006942)3.74769828
35striated muscle contraction (GO:0006941)3.74244987
36plasma membrane repair (GO:0001778)3.71991663
37ventricular cardiac muscle cell action potential (GO:0086005)3.71170830
38regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.69040711
39cardiac muscle hypertrophy (GO:0003300)3.68417978
40cardiac muscle cell development (GO:0055013)3.68086295
41bundle of His cell to Purkinje myocyte communication (GO:0086069)3.66541755
42striated muscle hypertrophy (GO:0014897)3.56716015
43actin filament-based movement (GO:0030048)3.56019908
44muscle tissue morphogenesis (GO:0060415)3.54121041
45ventricular cardiac muscle tissue morphogenesis (GO:0055010)3.49355336
46regulation of membrane repolarization (GO:0060306)3.48450820
47mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.46067139
48regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.45609920
49cardiac cell development (GO:0055006)3.45513585
50fatty acid elongation (GO:0030497)3.42791091
51regulation of cardiac muscle cell contraction (GO:0086004)3.42101188
52carnitine shuttle (GO:0006853)3.39862128
53muscle cell cellular homeostasis (GO:0046716)3.35475899
54response to inactivity (GO:0014854)3.32577928
55striated muscle cell development (GO:0055002)3.32241618
56myelination (GO:0042552)3.29907480
57axon ensheathment (GO:0008366)3.27576269
58ensheathment of neurons (GO:0007272)3.27576269
59cell communication involved in cardiac conduction (GO:0086065)3.24971083
60regulation of cardiac muscle contraction (GO:0055117)3.24741429
61skeletal muscle contraction (GO:0003009)3.24111093
62regulation of acyl-CoA biosynthetic process (GO:0050812)3.15434391
63response to epinephrine (GO:0071871)3.13377856
64heart trabecula formation (GO:0060347)3.10697958
65skeletal muscle tissue development (GO:0007519)3.10109302
66cellular response to epinephrine stimulus (GO:0071872)3.08696412
67tricarboxylic acid cycle (GO:0006099)3.07172200
68otic vesicle formation (GO:0030916)3.04523706
69muscle hypertrophy (GO:0014896)3.03297693
70cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.02585420
71myoblast fusion (GO:0007520)3.00280706
72positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.00256815
73skeletal muscle adaptation (GO:0043501)2.99608731
74respiratory electron transport chain (GO:0022904)2.93580965
75positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.93130811
76heart process (GO:0003015)2.92100681
77heart contraction (GO:0060047)2.92100681
78myotube differentiation (GO:0014902)2.87373538
79muscle organ development (GO:0007517)2.87011792
80fatty acid transmembrane transport (GO:1902001)2.84871805
81desmosome organization (GO:0002934)2.84602324
82muscle cell development (GO:0055001)2.84510328
83cardiac muscle cell action potential (GO:0086001)2.84340612
84electron transport chain (GO:0022900)2.83646827
85* muscle structure development (GO:0061061)2.82897784
86regulation of cardioblast differentiation (GO:0051890)2.81947780
87regulation of calcium ion transmembrane transporter activity (GO:1901019)2.81937358
88regulation of calcium ion transmembrane transport (GO:1903169)2.81937358
89striated muscle adaptation (GO:0014888)2.80321998
90membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.77668041
91cardiac muscle cell action potential involved in contraction (GO:0086002)2.76928372
92detection of calcium ion (GO:0005513)2.76116195
93muscle contraction (GO:0006936)2.75936291
94pyrimidine nucleobase catabolic process (GO:0006208)2.75808076
95negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.75645199
96negative regulation of calcium ion transmembrane transport (GO:1903170)2.75645199
97regulation of potassium ion transmembrane transporter activity (GO:1901016)2.74884369
98cardiac conduction (GO:0061337)2.72617511
99mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.72523739
100regulation of heart rate (GO:0002027)2.70995735
101relaxation of cardiac muscle (GO:0055119)2.70356112
102regulation of the force of heart contraction (GO:0002026)2.69253893
103muscle cell fate commitment (GO:0042693)2.68367143
104cell communication by electrical coupling (GO:0010644)2.67287221
105regulation of cofactor metabolic process (GO:0051193)2.66637453
106regulation of coenzyme metabolic process (GO:0051196)2.66637453
107positive regulation of action potential (GO:0045760)2.66583756
108skeletal muscle tissue regeneration (GO:0043403)2.66581139
109myelination in peripheral nervous system (GO:0022011)2.66347589
110peripheral nervous system axon ensheathment (GO:0032292)2.66347589
111neuromuscular synaptic transmission (GO:0007274)2.66154865
112positive regulation of sodium ion transmembrane transport (GO:1902307)2.64499830
113neuronal action potential propagation (GO:0019227)2.63379643
114carnitine transmembrane transport (GO:1902603)2.63258665
115regulation of heart rate by cardiac conduction (GO:0086091)2.63183679
116negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.62730505
117positive regulation of cardiac muscle cell differentiation (GO:2000727)2.62644491
118glycogen catabolic process (GO:0005980)2.62639209
119glucan biosynthetic process (GO:0009250)2.56546786
120glycogen biosynthetic process (GO:0005978)2.56546786
121muscle system process (GO:0003012)2.54867562
122ATP synthesis coupled proton transport (GO:0015986)2.54221141
123energy coupled proton transport, down electrochemical gradient (GO:0015985)2.54221141
124positive regulation of cation channel activity (GO:2001259)2.53458617
125regulation of skeletal muscle cell differentiation (GO:2001014)2.52685214
126cardiac muscle adaptation (GO:0014887)2.50550926
127cardiac muscle hypertrophy in response to stress (GO:0014898)2.50550926
128muscle hypertrophy in response to stress (GO:0003299)2.50550926
129amino-acid betaine transport (GO:0015838)2.50375896
130carnitine transport (GO:0015879)2.50375896
131regulation of heart contraction (GO:0008016)2.49816772
132relaxation of muscle (GO:0090075)2.48664958
133regulation of sequestering of triglyceride (GO:0010889)2.48563991
134striated muscle tissue development (GO:0014706)2.46209729
135regulation of muscle system process (GO:0090257)2.46014304
136postsynaptic membrane organization (GO:0001941)2.44886869
137syncytium formation by plasma membrane fusion (GO:0000768)2.43345204
138positive regulation of ion transmembrane transporter activity (GO:0032414)2.39453121
139cardiac chamber formation (GO:0003207)2.38432397
140cardiac ventricle formation (GO:0003211)2.37611073
141glucan catabolic process (GO:0009251)2.36268727

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.35473618
2GBX2_23144817_ChIP-Seq_PC3_Human2.99417534
3EP300_21415370_ChIP-Seq_HL-1_Mouse2.60598118
4IGF1R_20145208_ChIP-Seq_DFB_Human2.42030468
5CDX2_19796622_ChIP-Seq_MESCs_Mouse2.40945060
6RBPJ_22232070_ChIP-Seq_NCS_Mouse2.36105512
7SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.23701161
8SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.10214565
9EZH2_27304074_Chip-Seq_ESCs_Mouse2.08702060
10SALL1_21062744_ChIP-ChIP_HESCs_Human2.08692961
11JARID2_20064375_ChIP-Seq_MESCs_Mouse2.03292516
12SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.95427957
13AR_21572438_ChIP-Seq_LNCaP_Human1.91883603
14EZH2_18974828_ChIP-Seq_MESCs_Mouse1.89976538
15RNF2_18974828_ChIP-Seq_MESCs_Mouse1.89976538
16CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.82887766
17* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.79499768
18MTF2_20144788_ChIP-Seq_MESCs_Mouse1.76759939
19ESR1_20079471_ChIP-ChIP_T-47D_Human1.75161212
20EED_16625203_ChIP-ChIP_MESCs_Mouse1.74929681
21EZH2_27294783_Chip-Seq_ESCs_Mouse1.71929156
22SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.71682227
23SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.70843219
24DROSHA_22980978_ChIP-Seq_HELA_Human1.64136914
25* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.61769551
26POU3F2_20337985_ChIP-ChIP_501MEL_Human1.61678936
27JARID2_20075857_ChIP-Seq_MESCs_Mouse1.61636134
28PIAS1_25552417_ChIP-Seq_VCAP_Human1.60592056
29PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.59489567
30SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.58450832
31CBX2_27304074_Chip-Seq_ESCs_Mouse1.54277488
32FLI1_27457419_Chip-Seq_LIVER_Mouse1.51941294
33SUZ12_27294783_Chip-Seq_ESCs_Mouse1.51152708
34RNF2_27304074_Chip-Seq_ESCs_Mouse1.49831428
35ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.48143989
36* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.46852056
37SMAD3_21741376_ChIP-Seq_EPCs_Human1.45997140
38* TAF15_26573619_Chip-Seq_HEK293_Human1.43598909
39PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.40604443
40PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.38519357
41SUZ12_27294783_Chip-Seq_NPCs_Mouse1.38460494
42CBP_20019798_ChIP-Seq_JUKART_Human1.36843628
43IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.36843628
44VDR_22108803_ChIP-Seq_LS180_Human1.36297930
45TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.35554704
46* TBX20_22328084_ChIP-Seq_HEART_Mouse1.35554140
47* TBX20_22080862_ChIP-Seq_HEART_Mouse1.35554140
48ER_23166858_ChIP-Seq_MCF-7_Human1.34680776
49RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.34178434
50HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.33090691
51EZH2_27294783_Chip-Seq_NPCs_Mouse1.33054622
52SMAD4_21799915_ChIP-Seq_A2780_Human1.32144517
53ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.31090860
54ZNF217_24962896_ChIP-Seq_MCF-7_Human1.30850281
55EWS_26573619_Chip-Seq_HEK293_Human1.30402352
56CTBP1_25329375_ChIP-Seq_LNCAP_Human1.30182316
57SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.28848619
58GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28396687
59EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.28055583
60TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.27561718
61CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.27316835
62P300_19829295_ChIP-Seq_ESCs_Human1.26339246
63AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.24976317
64RNF2_27304074_Chip-Seq_NSC_Mouse1.23721755
65WT1_19549856_ChIP-ChIP_CCG9911_Human1.23278703
66GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.23236877
67AHR_22903824_ChIP-Seq_MCF-7_Human1.22137539
68ZNF274_21170338_ChIP-Seq_K562_Hela1.20778014
69NRF2_20460467_ChIP-Seq_MEFs_Mouse1.20716817
70NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.20716817
71KLF5_20875108_ChIP-Seq_MESCs_Mouse1.20533528
72HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.19729999
73FOXM1_26456572_ChIP-Seq_MCF-7_Human1.19672381
74RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.18455897
75ARNT_22903824_ChIP-Seq_MCF-7_Human1.17943752
76CTBP2_25329375_ChIP-Seq_LNCAP_Human1.17333954
77MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.16959517
78SOX2_21211035_ChIP-Seq_LN229_Gbm1.16487566
79SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.15540343
80TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11906316
81* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.11602888
82* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.11342628
83PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.11049317
84WT1_25993318_ChIP-Seq_PODOCYTE_Human1.10794736
85BMI1_23680149_ChIP-Seq_NPCS_Mouse1.10632986
86UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.10619556
87EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.10006355
88NR3C1_23031785_ChIP-Seq_PC12_Mouse1.09909577
89KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.09724297
90CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.08475412
91STAT3_23295773_ChIP-Seq_U87_Human1.08269646
92FUS_26573619_Chip-Seq_HEK293_Human1.07583054
93* P53_22127205_ChIP-Seq_FIBROBLAST_Human1.07446306
94TRIM28_21343339_ChIP-Seq_HEK293_Human1.06932844
95RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.06863550
96TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.06810145
97SOX9_26525672_Chip-Seq_HEART_Mouse1.06670049
98SMAD3_21741376_ChIP-Seq_HESCs_Human1.06605001
99CRX_20693478_ChIP-Seq_RETINA_Mouse1.06418574
100* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.05978226
101PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.05384560
102BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.05244122
103P53_22387025_ChIP-Seq_ESCs_Mouse1.05109009
104SMAD_19615063_ChIP-ChIP_OVARY_Human1.03410570
105NFE2_27457419_Chip-Seq_LIVER_Mouse1.02151618
106SMAD4_21741376_ChIP-Seq_HESCs_Human1.02102558
107* ISL1_27105846_Chip-Seq_CPCs_Mouse1.02051667
108MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.01876479
109BCAT_22108803_ChIP-Seq_LS180_Human1.01073931
110SMAD4_21741376_ChIP-Seq_EPCs_Human1.00415261
111* TCF4_23295773_ChIP-Seq_U87_Human0.99922142
112PCGF2_27294783_Chip-Seq_NPCs_Mouse0.98217522
113TP53_18474530_ChIP-ChIP_U2OS_Human0.97944016
114TP53_16413492_ChIP-PET_HCT116_Human0.97458964
115* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96473948
116TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.96387455
117TBL1_22424771_ChIP-Seq_293T_Human0.94480607
118AR_25329375_ChIP-Seq_VCAP_Human0.93230165
119* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.92874015
120CJUN_26792858_Chip-Seq_BT549_Human0.92371740
121NANOG_18555785_Chip-Seq_ESCs_Mouse0.91412269
122PCGF2_27294783_Chip-Seq_ESCs_Mouse0.91338502
123* VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.90899095
124TAL1_26923725_Chip-Seq_HPCs_Mouse0.90877570
125E2F1_18555785_Chip-Seq_ESCs_Mouse0.90815370
126EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.89901119
127POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.89864383
128TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89864383
129RING1B_27294783_Chip-Seq_ESCs_Mouse0.89222886

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis4.61118371
2MP0000751_myopathy4.42209990
3MP0004084_abnormal_cardiac_muscle3.96257051
4MP0000749_muscle_degeneration3.76977529
5MP0004036_abnormal_muscle_relaxation3.63897588
6MP0003646_muscle_fatigue3.59203103
7MP0004145_abnormal_muscle_electrophysio3.57920872
8MP0004215_abnormal_myocardial_fiber3.57390556
9MP0005330_cardiomyopathy2.92646049
10MP0003137_abnormal_impulse_conducting2.68730074
11MP0003950_abnormal_plasma_membrane2.68289695
12MP0005620_abnormal_muscle_contractility2.60473576
13MP0002972_abnormal_cardiac_muscle2.56854859
14MP0004087_abnormal_muscle_fiber2.43656376
15MP0002106_abnormal_muscle_physiology2.30148600
16MP0008775_abnormal_heart_ventricle2.24032129
17MP0000747_muscle_weakness2.23943491
18MP0004130_abnormal_muscle_cell2.23448835
19MP0004484_altered_response_of2.08746907
20MP0005369_muscle_phenotype2.01276723
21MP0004085_abnormal_heartbeat1.93088180
22MP0000920_abnormal_myelination1.87861708
23MP0000759_abnormal_skeletal_muscle1.86222091
24MP0000750_abnormal_muscle_regeneration1.82825805
25MP0010630_abnormal_cardiac_muscle1.74546870
26MP0002269_muscular_atrophy1.73101978
27MP0005385_cardiovascular_system_phenoty1.70484113
28MP0001544_abnormal_cardiovascular_syste1.70484113
29MP0006138_congestive_heart_failure1.69064176
30MP0004043_abnormal_pH_regulation1.67792988
31MP0003828_pulmonary_edema1.41940680
32MP0004270_analgesia1.32721277
33MP0003941_abnormal_skin_development1.30404053
34MP0003880_abnormal_central_pattern1.30171477
35MP0003136_yellow_coat_color1.29395940
36MP0002108_abnormal_muscle_morphology1.27643555
37MP0002127_abnormal_cardiovascular_syste1.24548834
38MP0004233_abnormal_muscle_weight1.22036905
39MP0005171_absent_coat_pigmentation1.21767442
40MP0003221_abnormal_cardiomyocyte_apopto1.16926554
41MP0010030_abnormal_orbit_morphology1.14986912
42MP0001486_abnormal_startle_reflex1.14927434
43MP0000566_synostosis1.14705660
44MP0002234_abnormal_pharynx_morphology1.13086356
45MP0003195_calcinosis1.11094564
46MP0005451_abnormal_body_composition1.10478919
47MP0009780_abnormal_chondrocyte_physiolo1.10171920
48MP0000372_irregular_coat_pigmentation1.10132135
49MP0006276_abnormal_autonomic_nervous1.08751235
50MP0002332_abnormal_exercise_endurance1.07698965
51MP0002102_abnormal_ear_morphology1.07232048
52MP0001984_abnormal_olfaction1.05996497
53MP0006036_abnormal_mitochondrial_physio1.03987768
54MP0005666_abnormal_adipose_tissue1.03744773
55MP0000778_abnormal_nervous_system1.02113651
56MP0002822_catalepsy1.00609586
57MP0001299_abnormal_eye_distance/1.00414675
58MP0005409_darkened_coat_color0.98224970
59MP0001485_abnormal_pinna_reflex0.96387852
60MP0004142_abnormal_muscle_tone0.96189790
61MP0001529_abnormal_vocalization0.95381432
62MP0005623_abnormal_meninges_morphology0.95056907
63MP0005551_abnormal_eye_electrophysiolog0.94293131
64MP0004147_increased_porphyrin_level0.92688648
65MP0003690_abnormal_glial_cell0.91316312
66MP0000383_abnormal_hair_follicle0.89966063
67MP0005266_abnormal_metabolism0.89210967
68MP0000762_abnormal_tongue_morphology0.87714101
69MP0000230_abnormal_systemic_arterial0.86013369
70MP0004510_myositis0.85898999
71MP0003755_abnormal_palate_morphology0.85739049
72MP0004185_abnormal_adipocyte_glucose0.85674979
73MP0002272_abnormal_nervous_system0.85339242
74MP0002638_abnormal_pupillary_reflex0.85325793
75MP0002734_abnormal_mechanical_nocicepti0.85197585
76MP0003937_abnormal_limbs/digits/tail_de0.84728196
77MP0000579_abnormal_nail_morphology0.84727802
78MP0000534_abnormal_ureter_morphology0.84428239
79MP0004272_abnormal_basement_membrane0.84353222
80MP0005375_adipose_tissue_phenotype0.81285313
81MP0000733_abnormal_muscle_development0.79775468
82MP0004742_abnormal_vestibular_system0.79675871
83MP0002233_abnormal_nose_morphology0.77599696
84MP0004885_abnormal_endolymph0.77475217
85MP0009384_cardiac_valve_regurgitation0.76697878
86MP0010678_abnormal_skin_adnexa0.74448594
87MP0003634_abnormal_glial_cell0.73187717
88MP0006072_abnormal_retinal_apoptosis0.72954788
89MP0004134_abnormal_chest_morphology0.72048410
90MP0008789_abnormal_olfactory_epithelium0.70367235
91MP0005423_abnormal_somatic_nervous0.69720558
92MP0004381_abnormal_hair_follicle0.68402143
93MP0004924_abnormal_behavior0.67432317
94MP0005386_behavior/neurological_phenoty0.67432317
95MP0005165_increased_susceptibility_to0.67349875
96MP0009250_abnormal_appendicular_skeleto0.66748920
97MP0003385_abnormal_body_wall0.66415760
98MP0000003_abnormal_adipose_tissue0.66016451
99MP0008569_lethality_at_weaning0.65846736
100MP0000462_abnormal_digestive_system0.65289191
101MP0000266_abnormal_heart_morphology0.65287652
102MP0000049_abnormal_middle_ear0.65072497
103MP0002229_neurodegeneration0.64360087
104MP0003567_abnormal_fetal_cardiomyocyte0.64331829
105MP0005670_abnormal_white_adipose0.62605632
106MP0005187_abnormal_penis_morphology0.62415176
107MP0002067_abnormal_sensory_capabilities0.62386859
108MP0000427_abnormal_hair_cycle0.62344753
109MP0001440_abnormal_grooming_behavior0.62154751
110MP0003122_maternal_imprinting0.61039551
111MP0000013_abnormal_adipose_tissue0.60566862
112MP0005248_abnormal_Harderian_gland0.59948136
113MP0001346_abnormal_lacrimal_gland0.59005265
114MP0005275_abnormal_skin_tensile0.58979462
115MP0001905_abnormal_dopamine_level0.58312170
116MP0002184_abnormal_innervation0.58169681
117MP0002064_seizures0.56974126
118MP0001661_extended_life_span0.56009217
119MP0003890_abnormal_embryonic-extraembry0.55736128
120MP0000647_abnormal_sebaceous_gland0.55512103
121MP0002971_abnormal_brown_adipose0.55008999
122MP0002938_white_spotting0.54517100
123MP0008438_abnormal_cutaneous_collagen0.54495978
124MP0002114_abnormal_axial_skeleton0.54112847
125MP0005253_abnormal_eye_physiology0.53947062
126MP0002752_abnormal_somatic_nervous0.53600314
127MP0010368_abnormal_lymphatic_system0.53101404
128MP0003935_abnormal_craniofacial_develop0.51906998
129MP0004133_heterotaxia0.51612629
130MP0001293_anophthalmia0.51307450
131MP0002177_abnormal_outer_ear0.50946021
132MP0009046_muscle_twitch0.50690041

Predicted human phenotypes

RankGene SetZ-score
1Muscle hypertrophy of the lower extremities (HP:0008968)6.21137336
2Sudden death (HP:0001699)6.15998011
3Calf muscle hypertrophy (HP:0008981)6.11989702
4Exercise-induced myalgia (HP:0003738)6.01062869
5Exercise-induced muscle cramps (HP:0003710)5.18357437
6Muscle fiber splitting (HP:0003555)5.14980187
7Ventricular tachycardia (HP:0004756)5.14711038
8Abnormality of the calf musculature (HP:0001430)4.99119372
9Hyporeflexia of lower limbs (HP:0002600)4.91427571
10Atrial fibrillation (HP:0005110)4.77859561
11Primary atrial arrhythmia (HP:0001692)4.38922079
12Supraventricular tachycardia (HP:0004755)4.16737557
13Muscle fiber inclusion bodies (HP:0100299)4.13868841
14Supraventricular arrhythmia (HP:0005115)4.06345463
15Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)4.04868123
16Difficulty running (HP:0009046)3.89717234
17EMG: myopathic abnormalities (HP:0003458)3.87058805
18Myoglobinuria (HP:0002913)3.80300871
19Right ventricular cardiomyopathy (HP:0011663)3.75405738
20Syncope (HP:0001279)3.75297465
21Prolonged QT interval (HP:0001657)3.75260295
22Abnormality of the left ventricular outflow tract (HP:0011103)3.73179917
23Subaortic stenosis (HP:0001682)3.73179917
24Lipoatrophy (HP:0100578)3.70217829
25Nemaline bodies (HP:0003798)3.66248003
26Ulnar deviation of the wrist (HP:0003049)3.53183091
27Dilated cardiomyopathy (HP:0001644)3.45351511
28Calcaneovalgus deformity (HP:0001848)3.36477701
29Type 1 muscle fiber predominance (HP:0003803)3.32913665
30Absent phalangeal crease (HP:0006109)3.21532290
31Deformed tarsal bones (HP:0008119)3.09715158
32Ventricular arrhythmia (HP:0004308)3.02838447
33Frequent falls (HP:0002359)2.99464880
34Myotonia (HP:0002486)2.85935286
35Bundle branch block (HP:0011710)2.77759192
36Neck muscle weakness (HP:0000467)2.75043463
37Increased connective tissue (HP:0009025)2.73944967
38Abnormal finger flexion creases (HP:0006143)2.73626640
39Palpitations (HP:0001962)2.69890208
40Muscle stiffness (HP:0003552)2.66039999
41Abnormal EKG (HP:0003115)2.62617141
42Degeneration of the lateral corticospinal tracts (HP:0002314)2.61407867
43Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.61407867
44Increased variability in muscle fiber diameter (HP:0003557)2.59979961
45Pheochromocytoma (HP:0002666)2.59337646
46Rhabdomyolysis (HP:0003201)2.53908654
47EMG: neuropathic changes (HP:0003445)2.53752878
48Left ventricular hypertrophy (HP:0001712)2.52652086
49Mildly elevated creatine phosphokinase (HP:0008180)2.48420302
50Gowers sign (HP:0003391)2.47083879
51Ventricular fibrillation (HP:0001663)2.46227630
52Round ear (HP:0100830)2.45990434
53Hip contracture (HP:0003273)2.45774892
54Acute necrotizing encephalopathy (HP:0006965)2.44591994
55Asymmetric septal hypertrophy (HP:0001670)2.42007881
56Malignant hyperthermia (HP:0002047)2.40986032
57Heart block (HP:0012722)2.39062585
58Abnormal mitochondria in muscle tissue (HP:0008316)2.33315199
59Slender build (HP:0001533)2.32879044
60Abnormality of skeletal muscle fiber size (HP:0012084)2.32220832
61Hypoplastic ischia (HP:0003175)2.28189793
62Abnormal atrioventricular conduction (HP:0005150)2.25314455
63Spinal rigidity (HP:0003306)2.19710726
64Neuroendocrine neoplasm (HP:0100634)2.19679086
65Fetal akinesia sequence (HP:0001989)2.16864135
66Rimmed vacuoles (HP:0003805)2.16848427
67Abnormality of the foot musculature (HP:0001436)2.15306848
68Scapular winging (HP:0003691)2.12601730
69Foot dorsiflexor weakness (HP:0009027)2.12442872
70Proximal amyotrophy (HP:0007126)2.12367758
71Ketoacidosis (HP:0001993)2.11546618
72Progressive macrocephaly (HP:0004481)2.11393249
73Distal arthrogryposis (HP:0005684)2.11372400
74Increased serum pyruvate (HP:0003542)2.10739125
75Abnormality of glycolysis (HP:0004366)2.10739125
76Acute encephalopathy (HP:0006846)2.09821817
77Palmoplantar keratoderma (HP:0000982)2.08414280
78Hepatic necrosis (HP:0002605)2.07922411
79Abnormality of the ischium (HP:0003174)2.05667234
80Central scotoma (HP:0000603)2.03794345
81Muscular dystrophy (HP:0003560)2.01972060
82Hypoplasia of the iris (HP:0007676)2.01236296
83Limited hip movement (HP:0008800)2.00593312
84Limb-girdle muscle atrophy (HP:0003797)1.99544292
85Distal lower limb muscle weakness (HP:0009053)1.99164375
86Fatigable weakness (HP:0003473)1.99092968
87Abnormality of the neuromuscular junction (HP:0003398)1.99092968
88Atrioventricular block (HP:0001678)1.95893629
89Abnormality of the shoulder girdle musculature (HP:0001435)1.95033214
90Hypoplastic left heart (HP:0004383)1.95009335
91Hyperkalemia (HP:0002153)1.92226368
92Steppage gait (HP:0003376)1.91539351
93Limb-girdle muscle weakness (HP:0003325)1.91342040
94Hepatocellular necrosis (HP:0001404)1.87779622
95Weak cry (HP:0001612)1.87360480
96Mitochondrial inheritance (HP:0001427)1.87010962
97Abnormality of the hip-girdle musculature (HP:0001445)1.86606953
98Abnormality of the musculature of the pelvis (HP:0001469)1.86606953
99Generalized muscle weakness (HP:0003324)1.86028888
100Long clavicles (HP:0000890)1.85737286
101Parakeratosis (HP:0001036)1.83455719
102Areflexia of lower limbs (HP:0002522)1.80667543
103Distal lower limb amyotrophy (HP:0008944)1.80194916
104Shoulder girdle muscle weakness (HP:0003547)1.78559879
105Abnormality of the calcaneus (HP:0008364)1.78027649
106Waddling gait (HP:0002515)1.77023573
107Metabolic alkalosis (HP:0200114)1.76859357
108Cerebral edema (HP:0002181)1.75422104
109Double outlet right ventricle (HP:0001719)1.73896387
110Congenital malformation of the right heart (HP:0011723)1.73896387
111Increased circulating renin level (HP:0000848)1.72816651
112Myopathic facies (HP:0002058)1.72623657
113Methylmalonic acidemia (HP:0002912)1.72524620
114Abnormality of the corticospinal tract (HP:0002492)1.72358641
115Abnormality of fatty-acid metabolism (HP:0004359)1.72206989
116Hypoglycemic coma (HP:0001325)1.71685014
117Centrally nucleated skeletal muscle fibers (HP:0003687)1.71629333
118Onion bulb formation (HP:0003383)1.68089179
119Difficulty climbing stairs (HP:0003551)1.67682004
120Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.66874985
121Popliteal pterygium (HP:0009756)1.65670090
122Bradycardia (HP:0001662)1.65568745
123Lower limb amyotrophy (HP:0007210)1.64767653
124Abnormality of dicarboxylic acid metabolism (HP:0010995)1.63239373
125Dicarboxylic aciduria (HP:0003215)1.63239373
126Conjunctival hamartoma (HP:0100780)1.61940367
127Large for gestational age (HP:0001520)1.60948891
128Delayed gross motor development (HP:0002194)1.60571256
129Broad metatarsal (HP:0001783)1.59923438
130Hypoplastic heart (HP:0001961)1.59655737
131Respiratory insufficiency due to muscle weakness (HP:0002747)1.59222022
132Increased CSF lactate (HP:0002490)1.58738440
133Broad-based gait (HP:0002136)1.47442045
134Hyperventilation (HP:0002883)1.47297430
135Bulbar palsy (HP:0001283)1.47292088
136Pelvic girdle muscle weakness (HP:0003749)1.45409347
137Ulnar deviation of finger (HP:0009465)1.40830457
138Oligomenorrhea (HP:0000876)1.39528710
139Facial diplegia (HP:0001349)1.38667289
140Metatarsus adductus (HP:0001840)1.35615411
141Type 2 muscle fiber atrophy (HP:0003554)1.35418214
142Exercise intolerance (HP:0003546)1.28746436

Predicted kinase interactions (KEA)

RankGene SetZ-score
1OBSCN4.88491867
2STK394.08118662
3PHKG23.56905891
4PHKG13.56905891
5TTN3.21195956
6OXSR12.71574554
7WNK42.65211875
8DMPK2.52379965
9MUSK2.30644129
10PIK3CA2.28943243
11PKN12.15206029
12INSRR2.10499073
13EPHB12.01418767
14MYLK1.96219404
15LMTK21.94512805
16ERBB31.74070489
17WNK11.71912903
18MAP3K41.66667057
19PDK41.63691996
20PDK31.63691996
21CASK1.62414050
22FRK1.51931613
23BCR1.46478621
24CAMK2D1.38944927
25TNIK1.37352404
26FGFR21.33221975
27PAK31.31757558
28PINK11.31526237
29GRK71.29054017
30MARK11.27946718
31MAP2K41.22423252
32ICK1.15257035
33TIE11.14531508
34ZAK1.11854082
35PDK21.11808745
36TRIM281.11641341
37MAP2K71.07510834
38MAP3K71.06424364
39PRKD11.06371841
40STK241.06141559
41SGK2231.03172795
42SGK4941.03172795
43MET1.00885185
44BCKDK1.00816573
45ROCK20.98391582
46PIK3CG0.97506496
47UHMK10.96172162
48CCNB10.95761259
49CAMK2A0.94228744
50LIMK10.93300084
51TRPM70.93155681
52NEK10.92709416
53MAP4K20.92304001
54ROCK10.90464499
55LATS10.90218772
56PRKCE0.89946796
57AKT30.87687564
58WNK30.87407980
59PRKAA20.86753415
60PNCK0.85968749
61MAPKAPK30.84618821
62MAPK120.83946140
63CAMK1G0.83499025
64NEK60.78672517
65CSNK1A1L0.77723113
66MAPKAPK50.76645879
67CAMK2B0.75857589
68PRPF4B0.74357985
69MAPK130.71792231
70CAMK2G0.71791859
71SGK20.68389527
72BMPR1B0.67076438
73GRK10.66305836
74MAP3K60.65943534
75NME10.65174834
76MARK20.64477168
77ACVR1B0.64356250
78CDC42BPA0.64083318
79IRAK20.61619747
80CAMK10.61011602
81PRKAA10.60844892
82NTRK20.60280767
83PRKACB0.59575309
84PRKG10.56844957
85PLK20.55364509
86NEK90.55359966
87EPHA40.55353841
88PRKACA0.54262210
89PAK60.53662472
90DYRK1B0.53477272
91CSNK1G30.52203977
92IRAK10.51957987
93KSR10.51468928
94SGK10.50826951
95CAMK40.50449580
96ILK0.50329921
97FER0.48903833
98CDK190.48754958
99CSNK1G10.48591299
100MAPK150.48556386
101SIK10.47484344
102DYRK20.46541228
103CAMK1D0.44104700
104ADRBK10.43721712
105CSNK1G20.43514039
106LATS20.41992190
107PDPK10.41668883
108PDGFRB0.40449308
109PRKCQ0.40426708
110TGFBR10.40395391
111DYRK30.40026520
112MKNK20.39851803
113AKT20.39727087
114CDK50.39214492
115NUAK10.38547228
116SGK30.37149763
117MAP2K10.37035302
118ERBB40.36928733
119EPHB20.36422122
120EPHA30.35727683
121STK110.35664386
122FGFR10.35344148
123STK38L0.33706104
124PRKCG0.33696052
125MAPK70.33418584
126MAP3K120.33309345
127TYRO30.31029126
128GSK3A0.30729575
129CSNK1D0.30467179
130PRKCH0.30412292
131PRKACG0.30074023
132DYRK1A0.29348148
133RPS6KA30.29057661
134STK30.26866105
135FLT30.24589377

Predicted pathways (KEGG)

RankGene SetZ-score
1Cardiac muscle contraction_Homo sapiens_hsa042603.37655285
2Fatty acid elongation_Homo sapiens_hsa000623.28860466
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.91113836
4Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.90986539
5Dilated cardiomyopathy_Homo sapiens_hsa054142.90842090
6Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.85991694
7Propanoate metabolism_Homo sapiens_hsa006402.77551579
8Oxidative phosphorylation_Homo sapiens_hsa001902.61569173
9Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.37362261
10Parkinsons disease_Homo sapiens_hsa050122.36510679
11Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.13287343
12Fatty acid metabolism_Homo sapiens_hsa012122.10466671
13Alzheimers disease_Homo sapiens_hsa050102.05249378
14Butanoate metabolism_Homo sapiens_hsa006502.01976130
15Fatty acid degradation_Homo sapiens_hsa000711.97261925
162-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.87682381
17Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.87541996
18Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.62289874
19Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.55973810
20* Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.49430568
21Huntingtons disease_Homo sapiens_hsa050161.30260477
22Sulfur metabolism_Homo sapiens_hsa009201.29342277
23Steroid biosynthesis_Homo sapiens_hsa001001.24646751
24Nitrogen metabolism_Homo sapiens_hsa009101.19694681
25Axon guidance_Homo sapiens_hsa043601.14421382
26Pyruvate metabolism_Homo sapiens_hsa006201.11088653
27Ether lipid metabolism_Homo sapiens_hsa005651.10617634
28Tight junction_Homo sapiens_hsa045301.07940819
29Phototransduction_Homo sapiens_hsa047441.05895724
30cGMP-PKG signaling pathway_Homo sapiens_hsa040221.04481090
31Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.03959795
32Carbon metabolism_Homo sapiens_hsa012001.03257223
33Nicotine addiction_Homo sapiens_hsa050331.02987499
34Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.01350690
35Hippo signaling pathway_Homo sapiens_hsa043901.00446240
36Vascular smooth muscle contraction_Homo sapiens_hsa042700.99208075
37Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.98641591
38Adherens junction_Homo sapiens_hsa045200.98562094
39Calcium signaling pathway_Homo sapiens_hsa040200.97979775
40Fatty acid biosynthesis_Homo sapiens_hsa000610.95811748
41Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.92122815
42Oxytocin signaling pathway_Homo sapiens_hsa049210.88432814
43Circadian entrainment_Homo sapiens_hsa047130.86627610
44Renin secretion_Homo sapiens_hsa049240.85198421
45Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.84471970
46Gastric acid secretion_Homo sapiens_hsa049710.84013409
47Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.82107740
48Arginine and proline metabolism_Homo sapiens_hsa003300.80957328
49Arginine biosynthesis_Homo sapiens_hsa002200.80569988
50Serotonergic synapse_Homo sapiens_hsa047260.77906599
51* Dopaminergic synapse_Homo sapiens_hsa047280.77408251
52Glutamatergic synapse_Homo sapiens_hsa047240.77341038
53Ovarian steroidogenesis_Homo sapiens_hsa049130.76729297
54GABAergic synapse_Homo sapiens_hsa047270.74104324
55alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.73967851
56Insulin secretion_Homo sapiens_hsa049110.73606951
57ECM-receptor interaction_Homo sapiens_hsa045120.72518613
58PPAR signaling pathway_Homo sapiens_hsa033200.71410147
59Lysine degradation_Homo sapiens_hsa003100.71272581
60cAMP signaling pathway_Homo sapiens_hsa040240.71259541
61Renal cell carcinoma_Homo sapiens_hsa052110.70817990
62Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.70776131
63Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.69872898
64beta-Alanine metabolism_Homo sapiens_hsa004100.69666029
65Taste transduction_Homo sapiens_hsa047420.69521216
66Starch and sucrose metabolism_Homo sapiens_hsa005000.69328714
67Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.68792788
68Linoleic acid metabolism_Homo sapiens_hsa005910.68784984
69Peroxisome_Homo sapiens_hsa041460.68553077
70Viral myocarditis_Homo sapiens_hsa054160.68477767
71Amphetamine addiction_Homo sapiens_hsa050310.67928794
72Type II diabetes mellitus_Homo sapiens_hsa049300.67305396
73Cholinergic synapse_Homo sapiens_hsa047250.66692097
74Focal adhesion_Homo sapiens_hsa045100.66115703
75Morphine addiction_Homo sapiens_hsa050320.65277844
76TGF-beta signaling pathway_Homo sapiens_hsa043500.64844102
77Sphingolipid metabolism_Homo sapiens_hsa006000.63151630
78Regulation of autophagy_Homo sapiens_hsa041400.60368033
79Insulin resistance_Homo sapiens_hsa049310.60356426
80Dorso-ventral axis formation_Homo sapiens_hsa043200.59517944
81Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.59314527
82Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.58679904
83Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.57946421
84Wnt signaling pathway_Homo sapiens_hsa043100.57407447
85Tryptophan metabolism_Homo sapiens_hsa003800.57278349
86Olfactory transduction_Homo sapiens_hsa047400.55981683
87Salivary secretion_Homo sapiens_hsa049700.53941301
88Selenocompound metabolism_Homo sapiens_hsa004500.53824496
89Glucagon signaling pathway_Homo sapiens_hsa049220.53171403
90Insulin signaling pathway_Homo sapiens_hsa049100.50948642
91Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.50875258
92Adipocytokine signaling pathway_Homo sapiens_hsa049200.50738080
93Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.49971874
94Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.49574463
95Pancreatic secretion_Homo sapiens_hsa049720.49384384
96* AMPK signaling pathway_Homo sapiens_hsa041520.47408775
97Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.45910010
98Long-term depression_Homo sapiens_hsa047300.45472044
99Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.42683343
100Melanoma_Homo sapiens_hsa052180.42565029
101Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.42410221
102Oocyte meiosis_Homo sapiens_hsa041140.41584315
103Gap junction_Homo sapiens_hsa045400.40137868
104Ras signaling pathway_Homo sapiens_hsa040140.39764984
105Biosynthesis of amino acids_Homo sapiens_hsa012300.39121688
106Thyroid hormone signaling pathway_Homo sapiens_hsa049190.38975144
107Arachidonic acid metabolism_Homo sapiens_hsa005900.38368938
108Regulation of actin cytoskeleton_Homo sapiens_hsa048100.38052151
109GnRH signaling pathway_Homo sapiens_hsa049120.35812051
110Aldosterone synthesis and secretion_Homo sapiens_hsa049250.35516446
111Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.35245957
112Histidine metabolism_Homo sapiens_hsa003400.34915118
113Circadian rhythm_Homo sapiens_hsa047100.33885491
114Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.33563569
115Cocaine addiction_Homo sapiens_hsa050300.31992223
116Basal cell carcinoma_Homo sapiens_hsa052170.31964631
117Phospholipase D signaling pathway_Homo sapiens_hsa040720.31757318
118ErbB signaling pathway_Homo sapiens_hsa040120.31306730
119Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.31306482
120Metabolic pathways_Homo sapiens_hsa011000.30735313
121Hedgehog signaling pathway_Homo sapiens_hsa043400.30454037
122Protein digestion and absorption_Homo sapiens_hsa049740.29630505
123Melanogenesis_Homo sapiens_hsa049160.27793823

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