PPP2R3C

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a regulatory subunit of the serine/threonine phosphatase, protein phosphatase 2. This protein is localized to both nuclear and cytoplasmic regions depending on cell cycle phase. Homozygous conditional knockout mice for this gene exhibit reduced numbers and impaired proliferation of immune system B cells. This protein may regulate the expression of the P-glycoprotein ATP-binding cassette transporter through its phosphatase activity. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein neddylation (GO:0045116)5.13471271
2DNA double-strand break processing (GO:0000729)4.83727845
37-methylguanosine mRNA capping (GO:0006370)4.57286571
4RNA capping (GO:0036260)4.51929040
57-methylguanosine RNA capping (GO:0009452)4.51929040
6mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.35887128
7proteasome assembly (GO:0043248)4.18184659
8energy coupled proton transport, down electrochemical gradient (GO:0015985)4.17183700
9ATP synthesis coupled proton transport (GO:0015986)4.17183700
10central nervous system myelination (GO:0022010)3.97778624
11axon ensheathment in central nervous system (GO:0032291)3.97778624
12mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.95526729
13establishment of integrated proviral latency (GO:0075713)3.90214114
14chaperone-mediated protein transport (GO:0072321)3.82366554
15transcription elongation from RNA polymerase I promoter (GO:0006362)3.79975406
16positive regulation of mitochondrial fission (GO:0090141)3.77708300
17transcription elongation from RNA polymerase III promoter (GO:0006385)3.75426792
18termination of RNA polymerase III transcription (GO:0006386)3.75426792
19termination of RNA polymerase I transcription (GO:0006363)3.72392960
20protein K6-linked ubiquitination (GO:0085020)3.71443982
21adenosine metabolic process (GO:0046085)3.68760288
22mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.63522182
23mitochondrial respiratory chain complex I assembly (GO:0032981)3.63522182
24NADH dehydrogenase complex assembly (GO:0010257)3.63522182
25transcription-coupled nucleotide-excision repair (GO:0006283)3.61399766
26establishment of viral latency (GO:0019043)3.54661137
27cullin deneddylation (GO:0010388)3.52410054
28negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.48880900
29respiratory chain complex IV assembly (GO:0008535)3.42740779
30RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.36808266
31telomere maintenance via semi-conservative replication (GO:0032201)3.35641936
32ribosomal small subunit assembly (GO:0000028)3.33621258
33protein complex biogenesis (GO:0070271)3.33406388
34regulation of cellular amino acid metabolic process (GO:0006521)3.32987992
35platelet dense granule organization (GO:0060155)3.31235299
36nucleotide-excision repair, DNA damage removal (GO:0000718)3.27215807
37DNA excision (GO:0044349)3.27215807
38respiratory electron transport chain (GO:0022904)3.23842793
39DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.23421734
40negative regulation of ligase activity (GO:0051352)3.23114705
41negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.23114705
42protein deneddylation (GO:0000338)3.22407967
43nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.22006041
44DNA strand elongation involved in DNA replication (GO:0006271)3.21215383
45DNA catabolic process, exonucleolytic (GO:0000738)3.20757642
46antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.20044041
47exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.20035641
48pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.19888596
49establishment of protein localization to mitochondrial membrane (GO:0090151)3.18738445
50positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.18028297
51electron transport chain (GO:0022900)3.17890015
52ribosomal small subunit biogenesis (GO:0042274)3.16779755
53intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.15668587
54signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.15668587
55protein-cofactor linkage (GO:0018065)3.15473254
56transcription from RNA polymerase I promoter (GO:0006360)3.14704674
57organelle disassembly (GO:1903008)3.14149940
58regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.12885952
59neural tube formation (GO:0001841)3.12818253
60transcription initiation from RNA polymerase I promoter (GO:0006361)3.11552554
61signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.10581254
62signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.10581254
63signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.10581254
64protein K11-linked ubiquitination (GO:0070979)3.07967032
65transcription elongation from RNA polymerase II promoter (GO:0006368)3.07685239
66viral transcription (GO:0019083)3.07336145
67DNA strand elongation (GO:0022616)3.06983966
68CENP-A containing nucleosome assembly (GO:0034080)3.06972738
69mitochondrial respiratory chain complex assembly (GO:0033108)3.06627361
70anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.04337532
71translational termination (GO:0006415)3.03704354
72synapsis (GO:0007129)3.03474614
73replication fork processing (GO:0031297)3.02664082
74DNA deamination (GO:0045006)3.02529169
75resolution of meiotic recombination intermediates (GO:0000712)3.00346404
76nucleotide-excision repair, DNA gap filling (GO:0006297)3.00257734
77signal transduction involved in DNA integrity checkpoint (GO:0072401)2.99607897
78signal transduction involved in DNA damage checkpoint (GO:0072422)2.99607897
79GTP biosynthetic process (GO:0006183)2.99280310
80piRNA metabolic process (GO:0034587)2.98769725
81kinetochore assembly (GO:0051382)2.98655570
82signal transduction involved in cell cycle checkpoint (GO:0072395)2.98608015
83meiosis I (GO:0007127)2.97868843
84purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)2.97505736
85antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.96725320
86DNA ligation (GO:0006266)2.95149777
87ribosomal large subunit biogenesis (GO:0042273)2.94848739
88cotranslational protein targeting to membrane (GO:0006613)2.91816378
89deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.90690351
90chromatin remodeling at centromere (GO:0031055)2.90226837
91telomere maintenance via recombination (GO:0000722)2.90036163
92negative regulation of transcription regulatory region DNA binding (GO:2000678)2.88411450
93sequestering of actin monomers (GO:0042989)2.88301749
94DNA-templated transcription, elongation (GO:0006354)2.88144375
95L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.87268466
96maturation of SSU-rRNA (GO:0030490)2.86505346
97cytochrome complex assembly (GO:0017004)2.85994895
98cell wall macromolecule metabolic process (GO:0044036)2.85821864
99base-excision repair, AP site formation (GO:0006285)2.84632682
100histone exchange (GO:0043486)2.82099190
101SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.81809692
102deoxyribonucleotide catabolic process (GO:0009264)2.81747775
103branched-chain amino acid catabolic process (GO:0009083)2.80171467
104protein targeting to ER (GO:0045047)2.80086739
105histone mRNA metabolic process (GO:0008334)2.79532806
106pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.78503131
107positive regulation of viral transcription (GO:0050434)2.78059294
108deoxyribose phosphate catabolic process (GO:0046386)2.77741998
109protein localization to mitochondrion (GO:0070585)2.77416616
110recombinational repair (GO:0000725)2.77198755
111spermatid nucleus differentiation (GO:0007289)2.76363199
112ribonucleoprotein complex disassembly (GO:0032988)2.75813445
113tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.74435047
114RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.74435047
115protein localization to endoplasmic reticulum (GO:0070972)2.72523225
116mannosylation (GO:0097502)2.71591631
117rRNA modification (GO:0000154)2.71473559
118pyrimidine nucleotide catabolic process (GO:0006244)2.71460192
119positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.71302137
120protein targeting to mitochondrion (GO:0006626)2.71258042
121double-strand break repair via homologous recombination (GO:0000724)2.71253493
122DNA damage response, detection of DNA damage (GO:0042769)2.70763071
123deoxyribonucleotide biosynthetic process (GO:0009263)2.69573742
124translation (GO:0006412)2.69566186
125positive regulation of ligase activity (GO:0051351)2.68558187
126regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.68102704
127establishment of protein localization to endoplasmic reticulum (GO:0072599)2.67851505
128mitotic recombination (GO:0006312)2.67772633
129positive regulation of protein homodimerization activity (GO:0090073)2.67677367
130establishment of protein localization to mitochondrion (GO:0072655)2.67421813
131centriole replication (GO:0007099)2.65935246
132spliceosomal snRNP assembly (GO:0000387)2.65096818
133DNA replication-independent nucleosome organization (GO:0034724)2.64857099
134DNA replication-independent nucleosome assembly (GO:0006336)2.64857099
135microtubule depolymerization (GO:0007019)2.64509030
136kinetochore organization (GO:0051383)2.64126587
137reciprocal DNA recombination (GO:0035825)2.62900361
138reciprocal meiotic recombination (GO:0007131)2.62900361
139male meiosis I (GO:0007141)2.61569200
140translational elongation (GO:0006414)2.61248088
141nucleotide-excision repair (GO:0006289)2.61124308
142deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.60994459
143metallo-sulfur cluster assembly (GO:0031163)2.60463033
144purine-containing compound salvage (GO:0043101)2.60357285
145purine nucleotide salvage (GO:0032261)2.59955007
146cytidine deamination (GO:0009972)2.57983592
147cytidine metabolic process (GO:0046087)2.57983592
148cytidine catabolic process (GO:0006216)2.57983592
149water-soluble vitamin biosynthetic process (GO:0042364)2.57969761
150positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.51650526
151rRNA methylation (GO:0031167)2.51256681
152regulation of mitochondrial fission (GO:0090140)2.49333961
153regulation of timing of cell differentiation (GO:0048505)2.49173765
154positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.48869513

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.14744675
2SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.94140477
3E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.86402705
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.83039918
5E2F7_22180533_ChIP-Seq_HELA_Human3.80067280
6EST1_17652178_ChIP-ChIP_JURKAT_Human3.67267498
7CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.48064024
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.13920387
9NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.12651446
10* MYC_18555785_ChIP-Seq_MESCs_Mouse2.95574856
11CREB1_15753290_ChIP-ChIP_HEK293T_Human2.92301955
12HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.86198408
13ZNF274_21170338_ChIP-Seq_K562_Hela2.73662535
14ETS1_20019798_ChIP-Seq_JURKAT_Human2.72128775
15CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.70388992
16HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.54354226
17HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.51705648
18TAF15_26573619_Chip-Seq_HEK293_Human2.48187924
19TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.33104822
20VDR_23849224_ChIP-Seq_CD4+_Human2.31994584
21E2F4_17652178_ChIP-ChIP_JURKAT_Human2.31413392
22MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.26952558
23IGF1R_20145208_ChIP-Seq_DFB_Human2.24567062
24ELF1_17652178_ChIP-ChIP_JURKAT_Human2.18163988
25MYC_18358816_ChIP-ChIP_MESCs_Mouse2.13957763
26ELK1_19687146_ChIP-ChIP_HELA_Human2.05095046
27MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.02348864
28VDR_22108803_ChIP-Seq_LS180_Human2.00318680
29YY1_21170310_ChIP-Seq_MESCs_Mouse1.98037668
30FOXP3_21729870_ChIP-Seq_TREG_Human1.95290250
31DCP1A_22483619_ChIP-Seq_HELA_Human1.95235517
32* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.93819057
33PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.92306595
34EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.91510312
35SRF_21415370_ChIP-Seq_HL-1_Mouse1.83795723
36RBPJ_22232070_ChIP-Seq_NCS_Mouse1.81186830
37FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.81061022
38HOXB4_20404135_ChIP-ChIP_EML_Mouse1.78601198
39THAP11_20581084_ChIP-Seq_MESCs_Mouse1.74525435
40IRF1_19129219_ChIP-ChIP_H3396_Human1.65143088
41EZH2_22144423_ChIP-Seq_EOC_Human1.62164593
42ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.59481816
43FUS_26573619_Chip-Seq_HEK293_Human1.51957467
44MYC_19079543_ChIP-ChIP_MESCs_Mouse1.51255602
45POU3F2_20337985_ChIP-ChIP_501MEL_Human1.49706604
46* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.47771392
47XRN2_22483619_ChIP-Seq_HELA_Human1.47077442
48TTF2_22483619_ChIP-Seq_HELA_Human1.46508188
49EZH2_27294783_Chip-Seq_NPCs_Mouse1.45061476
50FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.44116821
51YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.43868865
52ZFP57_27257070_Chip-Seq_ESCs_Mouse1.43702868
53GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.42061796
54ER_23166858_ChIP-Seq_MCF-7_Human1.39851158
55SUZ12_27294783_Chip-Seq_NPCs_Mouse1.39640250
56TP53_22573176_ChIP-Seq_HFKS_Human1.38777822
57NELFA_20434984_ChIP-Seq_ESCs_Mouse1.38246900
58* GABP_19822575_ChIP-Seq_HepG2_Human1.37926862
59NOTCH1_21737748_ChIP-Seq_TLL_Human1.35766310
60* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.33669799
61SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.33414756
62EWS_26573619_Chip-Seq_HEK293_Human1.32830766
63MYC_18940864_ChIP-ChIP_HL60_Human1.32632123
64NFE2_27457419_Chip-Seq_LIVER_Mouse1.32346418
65IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.29498614
66PCGF2_27294783_Chip-Seq_NPCs_Mouse1.28290739
67PADI4_21655091_ChIP-ChIP_MCF-7_Human1.25825408
68CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.25075861
69PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.22742991
70GBX2_23144817_ChIP-Seq_PC3_Human1.20569259
71FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.19401124
72FLI1_27457419_Chip-Seq_LIVER_Mouse1.18644934
73* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.17720817
74UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.15384382
75BP1_19119308_ChIP-ChIP_Hs578T_Human1.14489679
76CRX_20693478_ChIP-Seq_RETINA_Mouse1.13946463
77BMI1_23680149_ChIP-Seq_NPCS_Mouse1.12428074
78* NANOG_19829295_ChIP-Seq_ESCs_Human1.12320744
79* SOX2_19829295_ChIP-Seq_ESCs_Human1.12320744
80* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.11190213
81PCGF2_27294783_Chip-Seq_ESCs_Mouse1.10802959
82ERG_20887958_ChIP-Seq_HPC-7_Mouse1.09335652
83GATA3_26560356_Chip-Seq_TH2_Human1.08802994
84CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.08383230
85FOXA1_21572438_ChIP-Seq_LNCaP_Human1.08166051
86CBP_20019798_ChIP-Seq_JUKART_Human1.08074506
87IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.08074506
88MYCN_18555785_ChIP-Seq_MESCs_Mouse1.06511693
89BCAT_22108803_ChIP-Seq_LS180_Human1.06478880
90IRF8_22096565_ChIP-ChIP_GC-B_Human1.06277964
91CBX2_27304074_Chip-Seq_ESCs_Mouse1.03054684
92FOXA1_27270436_Chip-Seq_PROSTATE_Human1.00764507
93FOXA1_25329375_ChIP-Seq_VCAP_Human1.00764507
94MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.00442285
95* GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.00373201
96AUTS2_25519132_ChIP-Seq_293T-REX_Human0.99286514
97CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.98861835
98TOP2B_26459242_ChIP-Seq_MCF-7_Human0.98846610
99CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.98218714
100SALL1_21062744_ChIP-ChIP_HESCs_Human0.98151850
101SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.97682954
102ELK1_22589737_ChIP-Seq_MCF10A_Human0.96473885
103FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.96161434
104AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.96155141
105* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.94898080
106IRF8_21731497_ChIP-ChIP_J774_Mouse0.94661141
107* KLF5_20875108_ChIP-Seq_MESCs_Mouse0.94632723
108CTBP2_25329375_ChIP-Seq_LNCAP_Human0.94193252
109* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.93787468
110AR_20517297_ChIP-Seq_VCAP_Human0.93312251
111OCT4_21477851_ChIP-Seq_ESCs_Mouse0.93028091
112RNF2_27304074_Chip-Seq_NSC_Mouse0.92321183
113FOXH1_21741376_ChIP-Seq_EPCs_Human0.92275101
114POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.92212453
115* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.92039050
116HTT_18923047_ChIP-ChIP_STHdh_Human0.91920231
117P53_22387025_ChIP-Seq_ESCs_Mouse0.91629788
118POU5F1_16153702_ChIP-ChIP_HESCs_Human0.91022850
119NCOR_22424771_ChIP-Seq_293T_Human0.90839727
120CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.90709700
121NANOG_18555785_Chip-Seq_ESCs_Mouse0.90597683
122P300_19829295_ChIP-Seq_ESCs_Human0.89764997
123FLI1_21867929_ChIP-Seq_TH2_Mouse0.89687100
124TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.89322818
125TAL1_26923725_Chip-Seq_HPCs_Mouse0.88421348
126CTBP1_25329375_ChIP-Seq_LNCAP_Human0.88355864
127TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.88248613
128RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.87525911
129CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.86253916
130SOX17_20123909_ChIP-Seq_XEN_Mouse0.84819918
131MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.82537880
132SOX2_16153702_ChIP-ChIP_HESCs_Human0.81656765
133JUN_21703547_ChIP-Seq_K562_Human0.79199356
134CIITA_25753668_ChIP-Seq_RAJI_Human0.78374947
135PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.77840163
136GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.77421086
137CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.77191332
138ZFX_18555785_ChIP-Seq_MESCs_Mouse0.76361466
139POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.75470760
140E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.75411343
141SALL4_22934838_ChIP-ChIP_CD34+_Human0.71262309
142SPI1_23547873_ChIP-Seq_NB4_Human0.70595146
143SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.70300053
144EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.69386495

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.06505510
2MP0001529_abnormal_vocalization3.26124094
3MP0008058_abnormal_DNA_repair2.73608017
4MP0001986_abnormal_taste_sensitivity2.52297823
5MP0002102_abnormal_ear_morphology2.50176206
6MP0003806_abnormal_nucleotide_metabolis2.34160361
7MP0002938_white_spotting2.30937233
8MP0006054_spinal_hemorrhage2.30396147
9MP0005410_abnormal_fertilization2.26599077
10MP0001968_abnormal_touch/_nociception2.26396225
11MP0008057_abnormal_DNA_replication2.25388435
12MP0002638_abnormal_pupillary_reflex2.13832649
13MP0002736_abnormal_nociception_after2.12405769
14MP0001905_abnormal_dopamine_level2.12273137
15MP0003724_increased_susceptibility_to2.10239917
16MP0008877_abnormal_DNA_methylation2.06348586
17MP0010094_abnormal_chromosome_stability2.02513091
18MP0003693_abnormal_embryo_hatching2.00118380
19MP0006276_abnormal_autonomic_nervous1.95267835
20MP0003786_premature_aging1.94688563
21MP0006072_abnormal_retinal_apoptosis1.94230684
22MP0001984_abnormal_olfaction1.89254053
23MP0001485_abnormal_pinna_reflex1.88988544
24MP0009764_decreased_sensitivity_to1.87227899
25MP0004147_increased_porphyrin_level1.86407831
26MP0008260_abnormal_autophagy1.80195068
27MP0002735_abnormal_chemical_nociception1.77802086
28MP0003195_calcinosis1.75844615
29MP0008789_abnormal_olfactory_epithelium1.75055726
30MP0004142_abnormal_muscle_tone1.71000199
31MP0005671_abnormal_response_to1.69581919
32MP0003186_abnormal_redox_activity1.68794254
33MP0003787_abnormal_imprinting1.66334606
34MP0005646_abnormal_pituitary_gland1.65336737
35MP0002653_abnormal_ependyma_morphology1.63830777
36MP0005253_abnormal_eye_physiology1.63458186
37MP0003136_yellow_coat_color1.62660227
38MP0005409_darkened_coat_color1.62014188
39MP0005084_abnormal_gallbladder_morpholo1.60929985
40MP0003011_delayed_dark_adaptation1.59403173
41MP0004957_abnormal_blastocyst_morpholog1.59122507
42MP0008932_abnormal_embryonic_tissue1.58071794
43MP0009697_abnormal_copulation1.54440825
44MP0002148_abnormal_hypersensitivity_rea1.53409231
45MP0003718_maternal_effect1.53408024
46MP0003121_genomic_imprinting1.52112056
47MP0002272_abnormal_nervous_system1.51233064
48MP0000372_irregular_coat_pigmentation1.50351693
49MP0009379_abnormal_foot_pigmentation1.49292648
50MP0001764_abnormal_homeostasis1.44294907
51MP0002734_abnormal_mechanical_nocicepti1.43673173
52MP0003077_abnormal_cell_cycle1.42004311
53MP0005085_abnormal_gallbladder_physiolo1.40843543
54* MP0001800_abnormal_humoral_immune1.38039210
55MP0005423_abnormal_somatic_nervous1.37848683
56MP0001835_abnormal_antigen_presentation1.35648417
57MP0003567_abnormal_fetal_cardiomyocyte1.30104674
58MP0001929_abnormal_gametogenesis1.29571562
59MP0000569_abnormal_digit_pigmentation1.29566577
60MP0004742_abnormal_vestibular_system1.29035651
61MP0006292_abnormal_olfactory_placode1.26951587
62MP0000778_abnormal_nervous_system1.25360493
63MP0005499_abnormal_olfactory_system1.24963482
64MP0005394_taste/olfaction_phenotype1.24963482
65MP0000516_abnormal_urinary_system1.23499074
66MP0005367_renal/urinary_system_phenotyp1.23499074
67MP0002210_abnormal_sex_determination1.21437229
68MP0003698_abnormal_male_reproductive1.20961314
69MP0000920_abnormal_myelination1.20380220
70MP0006036_abnormal_mitochondrial_physio1.20125843
71MP0002067_abnormal_sensory_capabilities1.20092497
72MP0001188_hyperpigmentation1.19952494
73MP0009785_altered_susceptibility_to1.19586376
74MP0005171_absent_coat_pigmentation1.19270469
75MP0003879_abnormal_hair_cell1.15830677
76MP0002723_abnormal_immune_serum1.14356430
77MP0008007_abnormal_cellular_replicative1.12382235
78MP0003950_abnormal_plasma_membrane1.12280385
79MP0002822_catalepsy1.12195148
80MP0004270_analgesia1.11133979
81MP0003315_abnormal_perineum_morphology1.10102620
82MP0006035_abnormal_mitochondrial_morpho1.09764922
83MP0001293_anophthalmia1.08659851
84MP0002184_abnormal_innervation1.07509828
85* MP0002452_abnormal_antigen_presenting1.04094346
86MP0001145_abnormal_male_reproductive1.03738464
87MP0004381_abnormal_hair_follicle1.02559336
88MP0000631_abnormal_neuroendocrine_gland1.01589405
89MP0001486_abnormal_startle_reflex0.99728481
90MP0002064_seizures0.99685479
91MP0001970_abnormal_pain_threshold0.99684337
92MP0010386_abnormal_urinary_bladder0.99139063
93MP0009333_abnormal_splenocyte_physiolog0.98341855
94MP0008872_abnormal_physiological_respon0.97718368
95MP0002733_abnormal_thermal_nociception0.97009759
96MP0001963_abnormal_hearing_physiology0.96629976
97MP0002572_abnormal_emotion/affect_behav0.96038249
98MP0000653_abnormal_sex_gland0.95841775
99MP0000015_abnormal_ear_pigmentation0.95500226
100MP0001348_abnormal_lacrimal_gland0.94591913
101MP0005075_abnormal_melanosome_morpholog0.93853203
102MP0003656_abnormal_erythrocyte_physiolo0.93566428
103* MP0002420_abnormal_adaptive_immunity0.92514093
104MP0002751_abnormal_autonomic_nervous0.92358273
105MP0003122_maternal_imprinting0.91892699
106MP0002277_abnormal_respiratory_mucosa0.90797231
107MP0009046_muscle_twitch0.90410647
108MP0002752_abnormal_somatic_nervous0.90132756
109* MP0001819_abnormal_immune_cell0.90083982
110MP0004134_abnormal_chest_morphology0.89819453
111MP0003111_abnormal_nucleus_morphology0.89659439
112MP0001790_abnormal_immune_system0.89373105
113MP0005387_immune_system_phenotype0.89373105
114MP0002095_abnormal_skin_pigmentation0.88967437
115MP0006082_CNS_inflammation0.88564874
116MP0005645_abnormal_hypothalamus_physiol0.88520800
117MP0005025_abnormal_response_to0.88002673
118MP0005389_reproductive_system_phenotype0.87122585
119MP0005408_hypopigmentation0.86966509
120MP0001119_abnormal_female_reproductive0.86701321
121MP0002090_abnormal_vision0.85731142
122MP0002229_neurodegeneration0.85474618
123MP0005551_abnormal_eye_electrophysiolog0.85289539
124MP0000013_abnormal_adipose_tissue0.85210534
125MP0002419_abnormal_innate_immunity0.85191358
126MP0001727_abnormal_embryo_implantation0.84367809
127MP0000685_abnormal_immune_system0.84103193
128MP0004215_abnormal_myocardial_fiber0.83890977
129MP0009765_abnormal_xenobiotic_induced0.83518323
130MP0005174_abnormal_tail_pigmentation0.83244727
131MP0000026_abnormal_inner_ear0.82338971
132MP0001440_abnormal_grooming_behavior0.82035849
133MP0005365_abnormal_bile_salt0.81282959
134MP0008995_early_reproductive_senescence0.80803672
135* MP0000689_abnormal_spleen_morphology0.80782347
136MP0003635_abnormal_synaptic_transmissio0.80777706
137MP0009745_abnormal_behavioral_response0.80694858
138MP0002332_abnormal_exercise_endurance0.80278994
139MP0005377_hearing/vestibular/ear_phenot0.79540594
140MP0003878_abnormal_ear_physiology0.79540594
141MP0004133_heterotaxia0.79408341
142MP0002163_abnormal_gland_morphology0.78551068
143MP0005647_abnormal_sex_gland0.78280290
144MP0002234_abnormal_pharynx_morphology0.77930231
145MP0002160_abnormal_reproductive_system0.77804192
146MP0001919_abnormal_reproductive_system0.77126515
147MP0001853_heart_inflammation0.77062190
148MP0002882_abnormal_neuron_morphology0.76941180
149MP0005266_abnormal_metabolism0.76433952
150MP0002837_dystrophic_cardiac_calcinosis0.76093944
151MP0005000_abnormal_immune_tolerance0.76087265

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.73262805
2Congenital nonbullous ichthyosiform erythroderma (HP:0007479)4.65318913
3Mitochondrial inheritance (HP:0001427)4.25384297
4Progressive macrocephaly (HP:0004481)4.21301220
5Abnormal mitochondria in muscle tissue (HP:0008316)4.19347816
6Hyperventilation (HP:0002883)4.07547789
7Renal Fanconi syndrome (HP:0001994)3.99026063
8Methylmalonic aciduria (HP:0012120)3.91604664
9Hepatocellular necrosis (HP:0001404)3.79732973
10Increased hepatocellular lipid droplets (HP:0006565)3.70806281
11Increased CSF lactate (HP:0002490)3.68003520
12Cerebral hypomyelination (HP:0006808)3.60981697
13Acute encephalopathy (HP:0006846)3.54159946
143-Methylglutaconic aciduria (HP:0003535)3.46913107
15Abnormality of cells of the erythroid lineage (HP:0012130)3.43046881
16Abnormality of DNA repair (HP:0003254)3.27541273
17Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.12680837
18Lipid accumulation in hepatocytes (HP:0006561)3.12468182
19Abnormal number of erythroid precursors (HP:0012131)3.11615272
20Pancreatic cysts (HP:0001737)3.07917616
21Decreased activity of mitochondrial respiratory chain (HP:0008972)3.07155857
22Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.07155857
23Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.04798039
24Hepatic necrosis (HP:0002605)3.03957712
25Increased serum pyruvate (HP:0003542)3.03169217
26Abnormality of glycolysis (HP:0004366)3.03169217
27Parakeratosis (HP:0001036)2.91846367
28Thyroid-stimulating hormone excess (HP:0002925)2.87288805
29Medial flaring of the eyebrow (HP:0010747)2.84341812
30Leukodystrophy (HP:0002415)2.79078556
31Severe combined immunodeficiency (HP:0004430)2.78953910
32Congenital ichthyosiform erythroderma (HP:0007431)2.77389004
33B lymphocytopenia (HP:0010976)2.76373164
34Panhypogammaglobulinemia (HP:0003139)2.72693566
35Exertional dyspnea (HP:0002875)2.72334042
36Poikiloderma (HP:0001029)2.70737965
37Decreased central vision (HP:0007663)2.69809264
38Methylmalonic acidemia (HP:0002912)2.67673025
39Gait imbalance (HP:0002141)2.67190300
40Entropion (HP:0000621)2.64242681
41Hypothermia (HP:0002045)2.63112057
42Absent rod-and cone-mediated responses on ERG (HP:0007688)2.62592712
43Optic disc pallor (HP:0000543)2.60184766
44Stomatitis (HP:0010280)2.58644744
45Congenital primary aphakia (HP:0007707)2.57418188
46Abnormality of renal resorption (HP:0011038)2.57323889
47Thyroiditis (HP:0100646)2.57018876
48Molar tooth sign on MRI (HP:0002419)2.56746222
49Abnormality of midbrain morphology (HP:0002418)2.56746222
50Abnormality of B cell number (HP:0010975)2.55746310
51Dynein arm defect of respiratory motile cilia (HP:0012255)2.55483043
52Absent/shortened dynein arms (HP:0200106)2.55483043
53Hyperglycinemia (HP:0002154)2.54741070
54CNS hypomyelination (HP:0003429)2.48878901
55Abolished electroretinogram (ERG) (HP:0000550)2.48722279
56Birth length less than 3rd percentile (HP:0003561)2.47296337
57Constricted visual fields (HP:0001133)2.42338335
58Increased serum lactate (HP:0002151)2.40093460
59Exercise intolerance (HP:0003546)2.39318414
60Retinal dysplasia (HP:0007973)2.38806659
61Combined immunodeficiency (HP:0005387)2.37552975
62IgG deficiency (HP:0004315)2.37282646
63Nephrogenic diabetes insipidus (HP:0009806)2.35447205
64Abnormal respiratory motile cilium morphology (HP:0005938)2.34239359
65Abnormal respiratory epithelium morphology (HP:0012253)2.34239359
66Increased intramyocellular lipid droplets (HP:0012240)2.33271955
67Attenuation of retinal blood vessels (HP:0007843)2.29131694
68Hypoproteinemia (HP:0003075)2.28635502
69Respiratory difficulties (HP:0002880)2.27591485
70Lactic acidosis (HP:0003128)2.26811105
71Supernumerary spleens (HP:0009799)2.23460679
72Decreased electroretinogram (ERG) amplitude (HP:0000654)2.23272556
73Aplasia/Hypoplasia of the sacrum (HP:0008517)2.23009866
74Volvulus (HP:0002580)2.17028457
75Respiratory failure (HP:0002878)2.14994403
76Short tibia (HP:0005736)2.14840542
77Abnormality of dicarboxylic acid metabolism (HP:0010995)2.13904904
78Dicarboxylic aciduria (HP:0003215)2.13904904
79Type 2 muscle fiber atrophy (HP:0003554)2.12715546
80Aplastic anemia (HP:0001915)2.12466368
81Abnormality of eosinophils (HP:0001879)2.12039920
82Hypoplasia of the thymus (HP:0000778)2.11680859
83Congenital stationary night blindness (HP:0007642)2.11550422
84Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.10675311
85Degeneration of the lateral corticospinal tracts (HP:0002314)2.10675311
86Nephronophthisis (HP:0000090)2.09942363
87Genital tract atresia (HP:0001827)2.09606869
88Cerebral edema (HP:0002181)2.06564925
89Abnormal hair whorl (HP:0010721)2.04688434
90Vaginal atresia (HP:0000148)2.03804441
91Colon cancer (HP:0003003)2.03342281
92Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.03081227
93Aplasia/Hypoplasia of the tibia (HP:0005772)2.00690272
94Peripheral hypomyelination (HP:0007182)2.00502828
95Intestinal atresia (HP:0011100)1.99342734
96Chronic hepatic failure (HP:0100626)1.96468978
97Erythroderma (HP:0001019)1.96030768
98Eosinophilia (HP:0001880)1.92020659
99Abnormality of serum amino acid levels (HP:0003112)1.90938444
100Reticulocytopenia (HP:0001896)1.89718820
101Abnormality of the heme biosynthetic pathway (HP:0010472)1.89567502
102Focal motor seizures (HP:0011153)1.89429596
103Elevated erythrocyte sedimentation rate (HP:0003565)1.88667129
104Lethargy (HP:0001254)1.87878400
105Abnormal rod and cone electroretinograms (HP:0008323)1.87592922
106Abnormality of the septum pellucidum (HP:0007375)1.87289661
107Gonadotropin excess (HP:0000837)1.83613382
108Poor coordination (HP:0002370)1.83535606
109Bile duct proliferation (HP:0001408)1.82581641
110Abnormal biliary tract physiology (HP:0012439)1.82581641
111Abnormality of the labia minora (HP:0012880)1.82316041
112Abnormality of the anterior horn cell (HP:0006802)1.82187882
113Degeneration of anterior horn cells (HP:0002398)1.82187882
114Abnormality of the renal cortex (HP:0011035)1.80690323
115Optic nerve hypoplasia (HP:0000609)1.79250611
116Breast hypoplasia (HP:0003187)1.78774926
117Increased muscle lipid content (HP:0009058)1.78549789
118Prominent metopic ridge (HP:0005487)1.78350826
119Aplasia/Hypoplasia of the tongue (HP:0010295)1.78013763
120Abnormality of glycine metabolism (HP:0010895)1.77472247
121Abnormality of serine family amino acid metabolism (HP:0010894)1.77472247
122Chromsome breakage (HP:0040012)1.77375458
123Pancreatic fibrosis (HP:0100732)1.77328484
124Dyschromatopsia (HP:0007641)1.77127788
125Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.75850793
126Abnormal protein N-linked glycosylation (HP:0012347)1.75850793
127Abnormal protein glycosylation (HP:0012346)1.75850793
128Abnormal glycosylation (HP:0012345)1.75850793
129Congenital, generalized hypertrichosis (HP:0004540)1.75566186
130Postnatal microcephaly (HP:0005484)1.75361670
131Abnormality of the renal medulla (HP:0100957)1.75359728
132Atrophy/Degeneration involving motor neurons (HP:0007373)1.75089830
133Sensory axonal neuropathy (HP:0003390)1.74997524
134Stenosis of the external auditory canal (HP:0000402)1.74894859
135Abnormality of placental membranes (HP:0011409)1.73213622
136Amniotic constriction ring (HP:0009775)1.73213622
137Limb dystonia (HP:0002451)1.72904747
138Progressive inability to walk (HP:0002505)1.72831603
139Agnosia (HP:0010524)1.72647068
140Stomach cancer (HP:0012126)1.72447910
141Chromosomal breakage induced by crosslinking agents (HP:0003221)1.72129831
142Fragile nails (HP:0001808)1.71940161
143Renal cortical cysts (HP:0000803)1.71649796
144Asthma (HP:0002099)1.71645403
145Delusions (HP:0000746)1.70792877
146Abnormality of the ileum (HP:0001549)1.69992304
147CNS demyelination (HP:0007305)1.68811558
148Muscle fiber atrophy (HP:0100295)1.67989292
149T lymphocytopenia (HP:0005403)1.67836970
150Abnormality of chromosome stability (HP:0003220)1.67816548
151Increased IgM level (HP:0003496)1.67152939
152Atonic seizures (HP:0010819)1.67034890
153Emotional lability (HP:0000712)1.66930304
154Abnormal lung lobation (HP:0002101)1.65857306
155Prolonged neonatal jaundice (HP:0006579)1.64419769
156Pallor (HP:0000980)1.64417898
157Brittle hair (HP:0002299)1.64361626
158Cutaneous photosensitivity (HP:0000992)1.64359333
159Abnormality of alanine metabolism (HP:0010916)1.64190946
160Hyperalaninemia (HP:0003348)1.64190946
161Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.64190946
162X-linked dominant inheritance (HP:0001423)1.62866964
163Absent septum pellucidum (HP:0001331)1.62200721
164True hermaphroditism (HP:0010459)1.60924857
165Macrocytic anemia (HP:0001972)1.60309088
166Decreased subcutaneous fat (HP:0001002)1.57244101
167Type I transferrin isoform profile (HP:0003642)1.56975093
168Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.56931955

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK163.49710280
2TRIM283.06102654
3CASK2.73684535
4CDK192.68086176
5BUB12.51087990
6EIF2AK12.47221500
7ZAK2.45403040
8NUAK12.34270412
9MKNK12.24513125
10MAP4K22.24251503
11EIF2AK32.23630291
12VRK22.22607934
13STK392.20313210
14MST42.18649377
15PNCK2.08291647
16TNIK2.02352886
17WNK31.97044792
18BCR1.95249234
19BMPR1B1.92668184
20FRK1.91951600
21SRPK11.91352031
22BRAF1.89060720
23TESK21.87551536
24TLK11.77339158
25IRAK21.76982039
26TAOK31.76555747
27BCKDK1.70827446
28CCNB11.69713438
29OXSR11.69339886
30ARAF1.67321681
31WEE11.67259475
32VRK11.66144057
33MAP3K41.63517915
34PBK1.61888554
35MAP3K121.58889576
36CDC71.53182455
37MAPK131.39320539
38MKNK21.37207827
39GRK71.34293428
40MAPKAPK51.28878182
41PLK41.27976346
42NME21.27521070
43DYRK21.27180387
44LIMK11.26696018
45TSSK61.26633929
46IRAK41.26555133
47ADRBK21.22948087
48PIM21.20986010
49MARK11.19949991
50MUSK1.17624759
51NEK11.08815026
52EIF2AK21.07599909
53MAP2K71.05291949
54SIK31.03111505
55CDK81.02771254
56YES11.02006647
57BMPR20.95411446
58TGFBR20.94622526
59GRK10.86690573
60RPS6KA40.86361005
61PDK40.85900567
62PDK30.85900567
63DYRK30.82042689
64CSNK1G30.81352657
65CLK10.80451506
66ACVR1B0.79865814
67PASK0.79689442
68PLK30.79155745
69NME10.78644701
70BRSK20.77184824
71PLK20.75302040
72RIPK40.74561918
73PINK10.71220964
74AURKA0.71180643
75PIK3CG0.65703456
76IKBKE0.64965958
77CAMK2B0.64961610
78KDR0.63514509
79IKBKB0.62992451
80FES0.62750094
81FGR0.62272388
82MAP2K60.61588588
83TGFBR10.61365128
84EPHA40.60861202
85TXK0.60687644
86ERBB30.60148191
87GRK50.58321368
88MAP4K10.57000033
89TAF10.56850660
90STK38L0.56456273
91TAOK10.55026008
92PLK10.54265682
93PDK20.53863244
94SYK0.53156338
95CSNK2A20.53136893
96CAMKK20.52892073
97NEK60.51678385
98CDK140.51436391
99RPS6KA50.50428072
100UHMK10.49992437
101PRKCE0.49907441
102ADRBK10.48736387
103KIT0.48193742
104ITK0.47713766
105CSF1R0.47304485
106PKN10.47185368
107CDK30.46359223
108MATK0.46023625
109DYRK1A0.45887619
110MAP3K50.44929650
111RAF10.44919005
112CSNK2A10.44745645
113MAP3K60.44337950
114LYN0.41818790
115CHEK20.41069215
116PAK30.40809590
117CDK180.40770733
118TEC0.40400122
119CSNK1G10.39988888
120JAK30.39320251
121PRKCG0.38908192
122STK100.38594733
123MARK30.38548369
124CSNK1A1L0.37845849
125MINK10.37210383
126TNK20.37157027
127TIE10.37097209
128TTK0.36944586
129DAPK10.36882445
130STK40.36479790
131CSNK1G20.36435167
132CDK11A0.36106963
133CAMK2A0.36088433
134MAP2K40.35649890
135TESK10.35572966
136ATR0.35483823
137IRAK10.34659956
138CDK150.34455856
139AURKB0.31047400
140CAMK2G0.30208311

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.23005223
2RNA polymerase_Homo sapiens_hsa030203.78748541
3Oxidative phosphorylation_Homo sapiens_hsa001903.58506689
4Ribosome_Homo sapiens_hsa030103.56197505
5DNA replication_Homo sapiens_hsa030303.20445110
6Mismatch repair_Homo sapiens_hsa034303.08265209
7Parkinsons disease_Homo sapiens_hsa050123.02527107
8Nucleotide excision repair_Homo sapiens_hsa034202.96288301
9Propanoate metabolism_Homo sapiens_hsa006402.78160680
10Protein export_Homo sapiens_hsa030602.57206725
11Basal transcription factors_Homo sapiens_hsa030222.57002976
12Homologous recombination_Homo sapiens_hsa034402.38862423
13Huntingtons disease_Homo sapiens_hsa050162.32246616
14Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.18461620
15Alzheimers disease_Homo sapiens_hsa050102.14465051
16Pyrimidine metabolism_Homo sapiens_hsa002402.10629042
17Spliceosome_Homo sapiens_hsa030402.08525460
18Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.08318165
19Non-homologous end-joining_Homo sapiens_hsa034501.96387512
20RNA transport_Homo sapiens_hsa030131.64886929
21Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.62291982
22Fanconi anemia pathway_Homo sapiens_hsa034601.54647764
23RNA degradation_Homo sapiens_hsa030181.54325796
24Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.53793795
25Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.48432791
26Steroid biosynthesis_Homo sapiens_hsa001001.45682380
27SNARE interactions in vesicular transport_Homo sapiens_hsa041301.41968495
28Base excision repair_Homo sapiens_hsa034101.39083554
29Purine metabolism_Homo sapiens_hsa002301.38205552
30Collecting duct acid secretion_Homo sapiens_hsa049661.36458954
31Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.27032693
32Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.24984378
33Allograft rejection_Homo sapiens_hsa053301.12798963
34Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.11044268
35Fatty acid elongation_Homo sapiens_hsa000621.10379760
36Nitrogen metabolism_Homo sapiens_hsa009101.09435394
37Cell cycle_Homo sapiens_hsa041101.06906075
38Peroxisome_Homo sapiens_hsa041461.00065695
39Epstein-Barr virus infection_Homo sapiens_hsa051690.99124266
40Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.98522361
41Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.98072008
42Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.96384307
43Cardiac muscle contraction_Homo sapiens_hsa042600.94939780
44Vibrio cholerae infection_Homo sapiens_hsa051100.94215905
45Ether lipid metabolism_Homo sapiens_hsa005650.89198192
46One carbon pool by folate_Homo sapiens_hsa006700.88378152
47Rheumatoid arthritis_Homo sapiens_hsa053230.87980024
48Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.79753760
49Butanoate metabolism_Homo sapiens_hsa006500.76050096
50Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.75390874
51Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.74771465
52Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.71286527
53Vitamin B6 metabolism_Homo sapiens_hsa007500.71208498
54Nicotine addiction_Homo sapiens_hsa050330.70998879
55Systemic lupus erythematosus_Homo sapiens_hsa053220.70203068
56Graft-versus-host disease_Homo sapiens_hsa053320.68587374
57Autoimmune thyroid disease_Homo sapiens_hsa053200.68468034
58Asthma_Homo sapiens_hsa053100.67173962
59Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.65333811
60Primary immunodeficiency_Homo sapiens_hsa053400.64795707
61Regulation of autophagy_Homo sapiens_hsa041400.64712833
62Phagosome_Homo sapiens_hsa041450.64298558
63Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.62697158
64Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.61996299
65Staphylococcus aureus infection_Homo sapiens_hsa051500.60892899
66Primary bile acid biosynthesis_Homo sapiens_hsa001200.60700229
67Oocyte meiosis_Homo sapiens_hsa041140.59604575
68Maturity onset diabetes of the young_Homo sapiens_hsa049500.57989663
69Synaptic vesicle cycle_Homo sapiens_hsa047210.57944170
70Cysteine and methionine metabolism_Homo sapiens_hsa002700.56598880
71Sphingolipid metabolism_Homo sapiens_hsa006000.56545644
72* mRNA surveillance pathway_Homo sapiens_hsa030150.54262212
73Viral myocarditis_Homo sapiens_hsa054160.54170480
74Alcoholism_Homo sapiens_hsa050340.53217338
75Serotonergic synapse_Homo sapiens_hsa047260.51703211
76Intestinal immune network for IgA production_Homo sapiens_hsa046720.51683022
77NOD-like receptor signaling pathway_Homo sapiens_hsa046210.51192287
78Caffeine metabolism_Homo sapiens_hsa002320.49969477
79Metabolic pathways_Homo sapiens_hsa011000.49918851
80Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.49193477
81alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.48576937
82Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.45064581
83Tryptophan metabolism_Homo sapiens_hsa003800.43733990
84Type I diabetes mellitus_Homo sapiens_hsa049400.43317956
852-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.41944058
86Linoleic acid metabolism_Homo sapiens_hsa005910.41805672
87Arachidonic acid metabolism_Homo sapiens_hsa005900.41057587
88Phototransduction_Homo sapiens_hsa047440.39754837
89Olfactory transduction_Homo sapiens_hsa047400.38988612
90Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.38283640
91Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.37821986
92Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.37212079
93Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.36816492
94Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.36624957
95Hematopoietic cell lineage_Homo sapiens_hsa046400.36045144
96Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.35853238
97Leishmaniasis_Homo sapiens_hsa051400.35606454
98Shigellosis_Homo sapiens_hsa051310.33319826
99Glutathione metabolism_Homo sapiens_hsa004800.32480369
100Chemical carcinogenesis_Homo sapiens_hsa052040.32442565
101Retinol metabolism_Homo sapiens_hsa008300.31837237
102Legionellosis_Homo sapiens_hsa051340.30130566
103Antigen processing and presentation_Homo sapiens_hsa046120.29977999
104Folate biosynthesis_Homo sapiens_hsa007900.28367495
105Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.28220478
106Measles_Homo sapiens_hsa051620.27365984
107Pyruvate metabolism_Homo sapiens_hsa006200.26723921
108p53 signaling pathway_Homo sapiens_hsa041150.26248842
109Viral carcinogenesis_Homo sapiens_hsa052030.26066318
110African trypanosomiasis_Homo sapiens_hsa051430.25852880
111NF-kappa B signaling pathway_Homo sapiens_hsa040640.23281134
112Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.22798923
113Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.22677377
114N-Glycan biosynthesis_Homo sapiens_hsa005100.21612589
115Malaria_Homo sapiens_hsa051440.20473573
116Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.20263085
117Herpes simplex infection_Homo sapiens_hsa051680.19947368
118Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.19184446
119Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.18098282
120Pertussis_Homo sapiens_hsa051330.17725310
121Axon guidance_Homo sapiens_hsa043600.16489230
122Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.16431121
123Morphine addiction_Homo sapiens_hsa050320.16431115
124Salmonella infection_Homo sapiens_hsa051320.16103703
125Long-term depression_Homo sapiens_hsa047300.15752202
126RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.15460913
127Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.14869695

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