PPP2R5B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The product of this gene belongs to the phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a beta isoform of the regulatory subunit B56 subfamily. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)6.16276541
2regulation of short-term neuronal synaptic plasticity (GO:0048172)5.51058416
3positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.36665839
4locomotory exploration behavior (GO:0035641)5.22353283
5layer formation in cerebral cortex (GO:0021819)4.74030749
6regulation of synaptic vesicle exocytosis (GO:2000300)4.72006274
7glutamate secretion (GO:0014047)4.68564531
8synaptic vesicle exocytosis (GO:0016079)4.66861872
9cerebellar granule cell differentiation (GO:0021707)4.48255073
10positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.33770155
11vocalization behavior (GO:0071625)4.32665438
12synaptic vesicle docking involved in exocytosis (GO:0016081)4.27303789
13sodium ion export (GO:0071436)4.23661346
14regulation of synapse structural plasticity (GO:0051823)4.21836904
15regulation of synaptic vesicle transport (GO:1902803)4.10697780
16regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.06606855
17proline transport (GO:0015824)4.05340854
18neurotransmitter secretion (GO:0007269)3.99897746
19exploration behavior (GO:0035640)3.99656193
20activation of protein kinase A activity (GO:0034199)3.98750157
21cellular potassium ion homeostasis (GO:0030007)3.95007928
22protein localization to synapse (GO:0035418)3.84965362
23cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.83450759
24neuronal action potential propagation (GO:0019227)3.78467797
25regulation of glutamate receptor signaling pathway (GO:1900449)3.78380254
26cell communication by electrical coupling (GO:0010644)3.75925865
27regulation of neuronal synaptic plasticity (GO:0048168)3.72047389
28gamma-aminobutyric acid transport (GO:0015812)3.58371906
29dendritic spine morphogenesis (GO:0060997)3.51921843
30cell migration in hindbrain (GO:0021535)3.51330692
31neuromuscular process controlling balance (GO:0050885)3.49544937
32glycine transport (GO:0015816)3.49282090
33regulation of long-term neuronal synaptic plasticity (GO:0048169)3.49176772
34positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.49136702
35response to pheromone (GO:0019236)3.47537512
36negative regulation of microtubule polymerization (GO:0031115)3.43013725
37dendrite morphogenesis (GO:0048813)3.42790747
38membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.41750293
39postsynaptic membrane organization (GO:0001941)3.41085619
40L-amino acid import (GO:0043092)3.38328425
41regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.36236825
42neuron cell-cell adhesion (GO:0007158)3.35995987
43positive regulation of synapse maturation (GO:0090129)3.35019559
44regulation of synapse maturation (GO:0090128)3.33197851
45amino acid import (GO:0043090)3.32058301
46ionotropic glutamate receptor signaling pathway (GO:0035235)3.27419954
47axon cargo transport (GO:0008088)3.25292177
48vesicle transport along microtubule (GO:0047496)3.24540111
49organelle transport along microtubule (GO:0072384)3.19931372
50positive regulation of neurotransmitter transport (GO:0051590)3.18844144
51cell communication involved in cardiac conduction (GO:0086065)3.17987902
52positive regulation of neurotransmitter secretion (GO:0001956)3.17331355
53regulation of ARF protein signal transduction (GO:0032012)3.17219749
54membrane depolarization during action potential (GO:0086010)3.16400467
55negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.15961243
56neuromuscular process controlling posture (GO:0050884)3.14403108
57cytoskeletal anchoring at plasma membrane (GO:0007016)3.13876257
58negative regulation of synaptic transmission, GABAergic (GO:0032229)3.13872348
59G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.12819201
60positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.11440653
61synaptic transmission, glutamatergic (GO:0035249)3.11180750
62positive regulation of dendritic spine development (GO:0060999)3.10026189
63neurotransmitter transport (GO:0006836)3.09804226
64cerebellar Purkinje cell differentiation (GO:0021702)3.09619813
65positive regulation of synaptic transmission, GABAergic (GO:0032230)3.09544128
66positive regulation of potassium ion transmembrane transport (GO:1901381)3.07005297
67dendritic spine organization (GO:0097061)3.05347888
68cerebellar Purkinje cell layer development (GO:0021680)3.05030161
69long-term memory (GO:0007616)2.96710494
70neurotransmitter-gated ion channel clustering (GO:0072578)2.94823209
71innervation (GO:0060384)2.94521877
72synaptic vesicle endocytosis (GO:0048488)2.94481411
73potassium ion import (GO:0010107)2.94434933
74regulation of neurotransmitter secretion (GO:0046928)2.91991392
75cell differentiation in hindbrain (GO:0021533)2.91520296
76neuron recognition (GO:0008038)2.91409347
77response to auditory stimulus (GO:0010996)2.89642652
78mating behavior (GO:0007617)2.89575103
79potassium ion homeostasis (GO:0055075)2.88613072
80axon ensheathment in central nervous system (GO:0032291)2.88512626
81central nervous system myelination (GO:0022010)2.88512626
82prepulse inhibition (GO:0060134)2.88311149
83neuron-neuron synaptic transmission (GO:0007270)2.87996354
84positive regulation of membrane potential (GO:0045838)2.87917919
85detection of temperature stimulus involved in sensory perception (GO:0050961)2.87775290
86detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.87775290
87regulation of voltage-gated calcium channel activity (GO:1901385)2.87038639
88regulation of neurotransmitter levels (GO:0001505)2.86907687
89regulation of synaptic plasticity (GO:0048167)2.86285191
90alanine transport (GO:0032328)2.85923032
91axonal fasciculation (GO:0007413)2.85885576
92regulation of neurotransmitter transport (GO:0051588)2.85507318
93positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.85193765
94regulation of vesicle fusion (GO:0031338)2.84909482
95glutamate receptor signaling pathway (GO:0007215)2.84798561
96mitochondrion transport along microtubule (GO:0047497)2.84785607
97establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.84785607
98regulation of excitatory postsynaptic membrane potential (GO:0060079)2.82978123
99membrane repolarization (GO:0086009)2.81380011
100clathrin coat assembly (GO:0048268)2.81148126
101neuronal ion channel clustering (GO:0045161)2.80794928
102auditory behavior (GO:0031223)2.78782859
103establishment of mitochondrion localization (GO:0051654)2.77447234
104regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.77417742
105regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.77330865
106regulation of dendritic spine morphogenesis (GO:0061001)2.76699149
107neuromuscular process (GO:0050905)2.74733567
108cellular sodium ion homeostasis (GO:0006883)2.74198214
109negative regulation of dendrite morphogenesis (GO:0050774)2.74015884
110dopamine receptor signaling pathway (GO:0007212)2.72312714
111positive regulation of dendritic spine morphogenesis (GO:0061003)2.71718582
112regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.71646921
113positive regulation of potassium ion transport (GO:0043268)2.71566894
114regulation of postsynaptic membrane potential (GO:0060078)2.70593724
115positive regulation of axon extension (GO:0045773)2.70136244
116detection of temperature stimulus (GO:0016048)2.68043053
117establishment of nucleus localization (GO:0040023)2.67761057
118transmission of nerve impulse (GO:0019226)2.66666724
119adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.66409259
120regulation of synaptic transmission (GO:0050804)2.62489631
121regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.61822474
122protein targeting to plasma membrane (GO:0072661)2.60621145
123cellular response to catecholamine stimulus (GO:0071870)2.59485817
124cellular response to monoamine stimulus (GO:0071868)2.59485817
125positive regulation of fibroblast migration (GO:0010763)2.49546361
126establishment of synaptic vesicle localization (GO:0097480)2.47630644
127synaptic vesicle transport (GO:0048489)2.47630644
128membrane depolarization (GO:0051899)2.46694375

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.72057227
2SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.81071920
3SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.79149257
4EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.67457316
5RARB_27405468_Chip-Seq_BRAIN_Mouse2.64873673
6RNF2_18974828_ChIP-Seq_MESCs_Mouse2.61002885
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.61002885
8JARID2_20064375_ChIP-Seq_MESCs_Mouse2.60775393
9DROSHA_22980978_ChIP-Seq_HELA_Human2.59477583
10REST_21632747_ChIP-Seq_MESCs_Mouse2.56316880
11JARID2_20075857_ChIP-Seq_MESCs_Mouse2.51599137
12SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.50920548
13MTF2_20144788_ChIP-Seq_MESCs_Mouse2.49938347
14MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.32372679
15SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.31665823
16REST_18959480_ChIP-ChIP_MESCs_Mouse2.27994465
17EZH2_27294783_Chip-Seq_ESCs_Mouse2.26057823
18SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.22341063
19SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.21487985
20SUZ12_27294783_Chip-Seq_ESCs_Mouse2.20128405
21EZH2_27304074_Chip-Seq_ESCs_Mouse2.16282836
22GBX2_23144817_ChIP-Seq_PC3_Human2.06864659
23RNF2_27304074_Chip-Seq_ESCs_Mouse2.03067358
24IKZF1_21737484_ChIP-ChIP_HCT116_Human1.97815861
25CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.94376720
26NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.91582956
27ERG_21242973_ChIP-ChIP_JURKAT_Human1.90640398
28EED_16625203_ChIP-ChIP_MESCs_Mouse1.87834919
29* KDM2B_26808549_Chip-Seq_K562_Human1.83337807
30* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.82981998
31TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.75238561
32ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.72516910
33DNAJC2_21179169_ChIP-ChIP_NT2_Human1.70110891
34EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.60268008
35TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.59738379
36* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.58279307
37ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.52191124
38RARG_19884340_ChIP-ChIP_MEFs_Mouse1.47641640
39AR_21572438_ChIP-Seq_LNCaP_Human1.47259177
40KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.44516187
41RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.43108768
42ZNF274_21170338_ChIP-Seq_K562_Hela1.38778572
43NR3C1_23031785_ChIP-Seq_PC12_Mouse1.36336179
44* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.36139118
45TRIM28_21343339_ChIP-Seq_HEK293_Human1.36049606
46RING1B_27294783_Chip-Seq_ESCs_Mouse1.33416108
47TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.32613758
48WT1_25993318_ChIP-Seq_PODOCYTE_Human1.31382812
49ZNF263_19887448_ChIP-Seq_K562_Human1.27894916
50TCF7_22412390_ChIP-Seq_EML_Mouse1.27750137
51ELK3_25401928_ChIP-Seq_HUVEC_Human1.27063462
52CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.26986257
53UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.26551735
54GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.26281358
55* LXR_22292898_ChIP-Seq_THP-1_Human1.22690118
56TET1_21490601_ChIP-Seq_MESCs_Mouse1.21744614
57* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.20896914
58ZFP281_27345836_Chip-Seq_ESCs_Mouse1.20000835
59ESR2_21235772_ChIP-Seq_MCF-7_Human1.19133903
60AR_19668381_ChIP-Seq_PC3_Human1.18465874
61CTCF_27219007_Chip-Seq_Bcells_Human1.17454531
62THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.16462161
63OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.16016763
64P68_20966046_ChIP-Seq_HELA_Human1.15585215
65SOX2_21211035_ChIP-Seq_LN229_Gbm1.14826402
66RACK7_27058665_Chip-Seq_MCF-7_Human1.13579772
67CTCF_27219007_Chip-Seq_ERYTHROID_Human1.13075081
68KDM2B_26808549_Chip-Seq_DND41_Human1.11753343
69RING1B_27294783_Chip-Seq_NPCs_Mouse1.11017556
70SA1_27219007_Chip-Seq_ERYTHROID_Human1.10540716
71GATA1_19941827_ChIP-Seq_MEL_Mouse1.10268991
72GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.08647493
73TET1_21451524_ChIP-Seq_MESCs_Mouse1.08435565
74NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.07200794
75SMAD4_21799915_ChIP-Seq_A2780_Human1.05065537
76* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.04888178
77SRY_22984422_ChIP-ChIP_TESTIS_Rat1.04635997
78SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.04058465
79PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.02877692
80GATA1_19941826_ChIP-Seq_K562_Human1.02301889
81CTBP2_25329375_ChIP-Seq_LNCAP_Human1.01099722
82SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.99631976
83PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.99487899
84PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.99254448
85SMAD4_21741376_ChIP-Seq_HESCs_Human0.98442899
86* MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.97334438
87CDX2_19796622_ChIP-Seq_MESCs_Mouse0.96758284
88ZNF217_24962896_ChIP-Seq_MCF-7_Human0.96717359
89KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.96613604
90KLF4_19829295_ChIP-Seq_ESCs_Human0.96432463
91SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96151511
92KDM2B_26808549_Chip-Seq_JURKAT_Human0.95982221
93SMC4_20622854_ChIP-Seq_HELA_Human0.94855515
94ESR1_20079471_ChIP-ChIP_T-47D_Human0.94753884
95TP53_23651856_ChIP-Seq_MEFs_Mouse0.94640118
96EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.94566919
97AHR_22903824_ChIP-Seq_MCF-7_Human0.94270725
98* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.94083114
99ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.92263095
100SMAD3_21741376_ChIP-Seq_ESCs_Human0.91931184
101TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.91771491
102CREB1_26743006_Chip-Seq_LNCaP_Human0.91749657
103* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.91654117
104ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.91531434
105PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.91402029
106YAP1_20516196_ChIP-Seq_MESCs_Mouse0.91390931
107RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.90101484
108EP300_21415370_ChIP-Seq_HL-1_Mouse0.89932568
109TP63_17297297_ChIP-ChIP_HaCaT_Human0.89881563
110TP53_20018659_ChIP-ChIP_R1E_Mouse0.88109457
111STAT3_23295773_ChIP-Seq_U87_Human0.86697225
112P53_22127205_ChIP-Seq_FIBROBLAST_Human0.85868322
113TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.85663497
114ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.85624497
115STAT6_21828071_ChIP-Seq_BEAS2B_Human0.84129373
116OCT4_19829295_ChIP-Seq_ESCs_Human0.84111188
117GATA1_26923725_Chip-Seq_HPCs_Mouse0.83638339
118P300_27058665_Chip-Seq_ZR-75-30cells_Human0.83356795
119ARNT_22903824_ChIP-Seq_MCF-7_Human0.82594960
120RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.81944342
121* CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.80751551
122BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.80013354
123DPY_21335234_ChIP-Seq_ESCs_Mouse0.79916215
124TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.79916033
125AR_25329375_ChIP-Seq_VCAP_Human0.79474969
126SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.79380504
127SMAD3_21741376_ChIP-Seq_HESCs_Human0.79172561
128VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.78575910
129CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.77776525
130GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.77609488
131SMAD4_21741376_ChIP-Seq_ESCs_Human0.76860473

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.03262146
2MP0004270_analgesia4.13949895
3MP0003635_abnormal_synaptic_transmissio3.67191675
4MP0001968_abnormal_touch/_nociception3.30669774
5MP0004858_abnormal_nervous_system3.17997408
6MP0003880_abnormal_central_pattern3.08242347
7MP0002735_abnormal_chemical_nociception3.00576442
8MP0002734_abnormal_mechanical_nocicepti2.94738035
9MP0002063_abnormal_learning/memory/cond2.84550963
10MP0005423_abnormal_somatic_nervous2.70176337
11MP0009745_abnormal_behavioral_response2.67087889
12MP0002733_abnormal_thermal_nociception2.62409869
13MP0009046_muscle_twitch2.58894441
14MP0002064_seizures2.53984516
15MP0003329_amyloid_beta_deposits2.48820511
16MP0002736_abnormal_nociception_after2.47400593
17MP0009780_abnormal_chondrocyte_physiolo2.41430741
18MP0002909_abnormal_adrenal_gland2.36468306
19MP0001970_abnormal_pain_threshold2.26208612
20MP0002272_abnormal_nervous_system2.22250997
21MP0002572_abnormal_emotion/affect_behav2.18718212
22MP0002184_abnormal_innervation2.00787254
23MP0004811_abnormal_neuron_physiology1.96262448
24MP0008569_lethality_at_weaning1.90801334
25MP0001486_abnormal_startle_reflex1.89748476
26MP0002822_catalepsy1.86244237
27MP0001440_abnormal_grooming_behavior1.80088223
28MP0000955_abnormal_spinal_cord1.79360987
29MP0002067_abnormal_sensory_capabilities1.78051941
30MP0000778_abnormal_nervous_system1.74408784
31MP0006276_abnormal_autonomic_nervous1.71283943
32MP0003787_abnormal_imprinting1.66270268
33MP0000751_myopathy1.63948430
34MP0000013_abnormal_adipose_tissue1.63307591
35MP0003283_abnormal_digestive_organ1.61073542
36MP0001501_abnormal_sleep_pattern1.57977343
37MP0003123_paternal_imprinting1.53085284
38MP0004924_abnormal_behavior1.51383413
39MP0005386_behavior/neurological_phenoty1.51383413
40MP0002557_abnormal_social/conspecific_i1.48194616
41MP0004885_abnormal_endolymph1.44499840
42MP0004145_abnormal_muscle_electrophysio1.44255597
43MP0002882_abnormal_neuron_morphology1.40272423
44MP0005409_darkened_coat_color1.35916214
45MP0002066_abnormal_motor_capabilities/c1.34825653
46MP0003633_abnormal_nervous_system1.33649629
47MP0004510_myositis1.31219457
48MP0008961_abnormal_basal_metabolism1.30984547
49MP0003879_abnormal_hair_cell1.28520918
50MP0002837_dystrophic_cardiac_calcinosis1.28080155
51MP0003705_abnormal_hypodermis_morpholog1.25655714
52MP0000604_amyloidosis1.19023601
53MP0004233_abnormal_muscle_weight1.16302285
54MP0003634_abnormal_glial_cell1.15468671
55MP0008260_abnormal_autophagy1.15336755
56MP0005623_abnormal_meninges_morphology1.14599505
57MP0001984_abnormal_olfaction1.13782705
58MP0005645_abnormal_hypothalamus_physiol1.13261105
59MP0003631_nervous_system_phenotype1.12266220
60MP0001348_abnormal_lacrimal_gland1.08217670
61MP0004130_abnormal_muscle_cell1.08023128
62MP0000747_muscle_weakness1.07451795
63MP0001299_abnormal_eye_distance/1.04169090
64MP0002152_abnormal_brain_morphology1.03234163
65MP0001502_abnormal_circadian_rhythm1.01136806
66MP0002229_neurodegeneration1.01067031
67MP0005646_abnormal_pituitary_gland0.94867858
68MP0001958_emphysema0.92541374
69MP0000569_abnormal_digit_pigmentation0.89795215
70MP0004085_abnormal_heartbeat0.89472211
71MP0001188_hyperpigmentation0.89206892
72MP0003172_abnormal_lysosome_physiology0.88631206
73MP0004142_abnormal_muscle_tone0.87860365
74MP0010234_abnormal_vibrissa_follicle0.87660188
75MP0002069_abnormal_eating/drinking_beha0.86726348
76MP0000920_abnormal_myelination0.86692310
77MP0003632_abnormal_nervous_system0.86615937
78MP0003122_maternal_imprinting0.85490476
79MP0004215_abnormal_myocardial_fiber0.85411088
80MP0008438_abnormal_cutaneous_collagen0.84597138
81MP0010386_abnormal_urinary_bladder0.83218108
82MP0003137_abnormal_impulse_conducting0.83073005
83MP0004147_increased_porphyrin_level0.82472937
84MP0000003_abnormal_adipose_tissue0.82065423
85MP0004742_abnormal_vestibular_system0.81525419
86MP0003075_altered_response_to0.80155818
87MP0003279_aneurysm0.79324936
88MP0005535_abnormal_body_temperature0.76523310
89MP0005187_abnormal_penis_morphology0.75888844
90MP0004043_abnormal_pH_regulation0.75634961
91MP0008874_decreased_physiological_sensi0.75520759
92MP0002653_abnormal_ependyma_morphology0.74532886
93MP0003690_abnormal_glial_cell0.74482063
94MP0003303_peritoneal_inflammation0.72948673
95MP0000534_abnormal_ureter_morphology0.72359775
96MP0004036_abnormal_muscle_relaxation0.71481719
97MP0002090_abnormal_vision0.69926209
98MP0002752_abnormal_somatic_nervous0.69171323
99MP0001849_ear_inflammation0.69007164
100MP0002269_muscular_atrophy0.68239236
101MP0008872_abnormal_physiological_respon0.67199746
102MP0001963_abnormal_hearing_physiology0.66557336
103MP0001529_abnormal_vocalization0.64602017
104MP0001177_atelectasis0.63824908
105MP0003646_muscle_fatigue0.63320929
106MP0004484_altered_response_of0.62704401
107MP0001943_abnormal_respiration0.62480254
108MP0001986_abnormal_taste_sensitivity0.62400004
109MP0000749_muscle_degeneration0.62372089
110MP0001905_abnormal_dopamine_level0.61805394
111MP0004087_abnormal_muscle_fiber0.61567750
112MP0004084_abnormal_cardiac_muscle0.61462175
113MP0002089_abnormal_postnatal_growth/wei0.60749336
114MP0000759_abnormal_skeletal_muscle0.59717723
115MP0005394_taste/olfaction_phenotype0.59418065
116MP0005499_abnormal_olfactory_system0.59418065
117MP0005620_abnormal_muscle_contractility0.59318629
118MP0005167_abnormal_blood-brain_barrier0.58785639
119MP0005257_abnormal_intraocular_pressure0.58585334
120MP0005058_abnormal_lysosome_morphology0.57776448
121MP0003045_fibrosis0.56929550
122MP0005166_decreased_susceptibility_to0.55626176
123MP0002638_abnormal_pupillary_reflex0.54501548
124MP0002332_abnormal_exercise_endurance0.52186977
125MP0003091_abnormal_cell_migration0.49398391
126MP0000681_abnormal_thyroid_gland0.49330968
127MP0010769_abnormal_survival0.48856651
128MP0000579_abnormal_nail_morphology0.48447154

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)5.97572389
2Visual hallucinations (HP:0002367)4.56645569
3Action tremor (HP:0002345)4.34102073
4Supranuclear gaze palsy (HP:0000605)4.26315594
5Focal motor seizures (HP:0011153)4.23592299
6Focal seizures (HP:0007359)4.17679362
7Obstructive sleep apnea (HP:0002870)4.00487909
8Ankle clonus (HP:0011448)3.93492410
9Progressive cerebellar ataxia (HP:0002073)3.29220582
10Depression (HP:0000716)3.16953921
11Papilledema (HP:0001085)3.15114408
12Mutism (HP:0002300)3.11097031
13Termporal pattern (HP:0011008)3.08843416
14Insidious onset (HP:0003587)3.08843416
15Atonic seizures (HP:0010819)3.07099848
16Pheochromocytoma (HP:0002666)3.04186173
17Epileptic encephalopathy (HP:0200134)3.00029238
18Abnormality of the lower motor neuron (HP:0002366)2.94252545
19Insomnia (HP:0100785)2.85944876
20Poor eye contact (HP:0000817)2.82534082
21Urinary urgency (HP:0000012)2.81165684
22Ventricular fibrillation (HP:0001663)2.80525945
23Generalized tonic-clonic seizures (HP:0002069)2.78592396
24Absence seizures (HP:0002121)2.78270791
25Neurofibrillary tangles (HP:0002185)2.74954468
26Impaired social interactions (HP:0000735)2.74123889
27Abnormal social behavior (HP:0012433)2.74123889
28Cerebral inclusion bodies (HP:0100314)2.73517948
29Urinary bladder sphincter dysfunction (HP:0002839)2.73126152
30Peripheral hypomyelination (HP:0007182)2.70741494
31Truncal ataxia (HP:0002078)2.65038797
32Torticollis (HP:0000473)2.62917884
33Anxiety (HP:0000739)2.59737123
34Postural instability (HP:0002172)2.59715350
35Abnormal eating behavior (HP:0100738)2.59693303
36Impaired vibration sensation in the lower limbs (HP:0002166)2.58459204
37Spastic gait (HP:0002064)2.57752012
38Neuroendocrine neoplasm (HP:0100634)2.54991516
39Abnormality of the corticospinal tract (HP:0002492)2.52693378
40Febrile seizures (HP:0002373)2.52247300
41Megalencephaly (HP:0001355)2.52145797
42Bundle branch block (HP:0011710)2.48942208
43Hypercortisolism (HP:0001578)2.47586751
44Dysdiadochokinesis (HP:0002075)2.46341395
45Dysmetria (HP:0001310)2.44052034
46Dialeptic seizures (HP:0011146)2.43786348
47Tetraplegia (HP:0002445)2.43466094
48Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.41351641
49Agitation (HP:0000713)2.40498834
50Intention tremor (HP:0002080)2.38974481
51Cerebral aneurysm (HP:0004944)2.37325798
52Hemiplegia (HP:0002301)2.35015458
53Lower limb muscle weakness (HP:0007340)2.33491054
54Ulnar claw (HP:0001178)2.32238904
55Limb dystonia (HP:0002451)2.31900031
56Sleep apnea (HP:0010535)2.29773236
57Genetic anticipation (HP:0003743)2.29601369
58Focal dystonia (HP:0004373)2.27865305
59Upper limb amyotrophy (HP:0009129)2.24917441
60Distal upper limb amyotrophy (HP:0007149)2.24917441
61Hemiparesis (HP:0001269)2.24821819
62Rigidity (HP:0002063)2.24734518
63Rapidly progressive (HP:0003678)2.22980137
64Hammertoe (HP:0001765)2.22407671
65Amblyopia (HP:0000646)2.19695362
66Apathy (HP:0000741)2.19574368
67Delusions (HP:0000746)2.18917414
68Amyotrophic lateral sclerosis (HP:0007354)2.18575661
69Scanning speech (HP:0002168)2.18451915
70Failure to thrive in infancy (HP:0001531)2.17743550
71Clonus (HP:0002169)2.17619381
72Pointed chin (HP:0000307)2.15856665
73Craniofacial dystonia (HP:0012179)2.15799098
74Hand muscle atrophy (HP:0009130)2.14688020
75Neoplasm of the peripheral nervous system (HP:0100007)2.12125975
76Broad-based gait (HP:0002136)2.08238314
77Bradykinesia (HP:0002067)2.08161733
78EEG with generalized epileptiform discharges (HP:0011198)2.07361069
79Hypsarrhythmia (HP:0002521)2.06717473
80Impaired smooth pursuit (HP:0007772)2.04894443
81Cerebral hypomyelination (HP:0006808)2.02982116
82Progressive inability to walk (HP:0002505)2.02708068
83Gaze-evoked nystagmus (HP:0000640)2.02449363
84Myotonia (HP:0002486)2.02195818
85Abnormality of binocular vision (HP:0011514)2.01868256
86Diplopia (HP:0000651)2.01868256
87Foot dorsiflexor weakness (HP:0009027)2.01804075
88Hypoventilation (HP:0002791)2.01329970
89Dysmetric saccades (HP:0000641)2.00688108
90Epileptiform EEG discharges (HP:0011182)2.00595952
91Spinal canal stenosis (HP:0003416)1.98356994
92Neuronal loss in central nervous system (HP:0002529)1.98048495
93Diminished motivation (HP:0000745)1.97749488
94Abnormal gallbladder physiology (HP:0012438)1.97319267
95Cholecystitis (HP:0001082)1.97319267
96Akinesia (HP:0002304)1.97085717
97Macroorchidism (HP:0000053)1.96713294
98Abnormality of pain sensation (HP:0010832)1.95409801
99Impaired pain sensation (HP:0007328)1.95409801
100Hyperacusis (HP:0010780)1.93769916
101Aplasia/Hypoplasia of the brainstem (HP:0007362)1.93156150
102Hypoplasia of the brainstem (HP:0002365)1.93156150
103Lower limb amyotrophy (HP:0007210)1.92035523
104Difficulty running (HP:0009046)1.90639630
105Fetal akinesia sequence (HP:0001989)1.88229156
106Stereotypic behavior (HP:0000733)1.88161234
107Postural tremor (HP:0002174)1.88061509
108Polyphagia (HP:0002591)1.87632685
109Abnormal EKG (HP:0003115)1.85967544
110Annular pancreas (HP:0001734)1.84901980
111Drooling (HP:0002307)1.84559028
112Excessive salivation (HP:0003781)1.84559028
113Prolonged QT interval (HP:0001657)1.84323571
114Decreased motor nerve conduction velocity (HP:0003431)1.84288121
115Slow progression (HP:0003677)1.84198381
116Abnormality of the foot musculature (HP:0001436)1.81689214
117Distal sensory impairment (HP:0002936)1.81392619
118Growth hormone excess (HP:0000845)1.78159805
119Difficulty climbing stairs (HP:0003551)1.78003358
120Reticulocytosis (HP:0001923)1.74334480
121Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.74275818
122Status epilepticus (HP:0002133)1.73418093
123Turricephaly (HP:0000262)1.69339575
124Onion bulb formation (HP:0003383)1.68990051
125Shallow orbits (HP:0000586)1.68180727
126Protrusio acetabuli (HP:0003179)1.67616854
127Increased variability in muscle fiber diameter (HP:0003557)1.67574109
128Spastic tetraparesis (HP:0001285)1.65685402
129Hyperparathyroidism (HP:0000843)1.64711425
130Distal lower limb amyotrophy (HP:0008944)1.63191970
131Slow saccadic eye movements (HP:0000514)1.62139111

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K94.28827942
2MARK13.89226965
3NTRK33.43169173
4MINK12.89229114
5KSR22.73543124
6NTRK12.72706304
7PAK62.56565447
8PRKD32.28959175
9MAP3K42.27178687
10EPHA42.22758490
11DAPK22.11737796
12CAMKK12.06882027
13PHKG12.05471290
14PHKG22.05471290
15LMTK21.94210212
16LATS21.92419022
17TRIB31.86086668
18MAP3K21.69759577
19NTRK21.69364687
20RIPK11.55961610
21MAP2K41.48424980
22CDK51.47912470
23KSR11.45156634
24RET1.44308160
25SCYL21.39983342
26MAP2K71.39036245
27MAP3K111.35244587
28UHMK11.34086890
29CAMKK21.33803562
30TAOK11.30201164
31STK381.29118068
32ARAF1.21273347
33PAK31.16296460
34NEK11.14544269
35TYRO31.14370057
36LIMK11.13672511
37GRK51.10685075
38ERN11.08115073
39MAPK121.06157940
40CASK1.05267223
41ALK1.03413706
42PRKCH1.00745618
43CDK140.99464448
44EPHB10.98728332
45TAOK20.97719795
46MAPK130.95570616
47CDK150.94042855
48CDK180.93042748
49PRKCG0.92893308
50BRAF0.92650025
51SGK20.89759148
52SIK20.86357683
53DAPK10.85924294
54PKN20.85209669
55PRKD20.85201587
56PRPF4B0.82813750
57TNK20.82542508
58DYRK1B0.82461332
59MARK20.81557690
60MAP3K120.81004247
61CDK11A0.80764494
62PDGFRA0.79988438
63STK110.79146619
64SIK10.78773573
65SGK4940.78616829
66SGK2230.78616829
67MAP3K10.78427629
68FER0.76822239
69RPS6KA20.74644645
70WNK10.74383333
71CSNK1G20.71686105
72MAP2K10.71427241
73PDPK10.70622637
74PINK10.68275710
75CDK190.67475567
76RIPK40.67112049
77PKN10.66955024
78CDC42BPA0.66684297
79WNK30.64794002
80MAP2K30.62715800
81PDK10.61703515
82PTK20.60584929
83PLK20.60272146
84CAMK2A0.59670866
85CAMK1G0.59007319
86CAMK10.57856957
87PRKCZ0.57651702
88ICK0.57588787
89CAMK40.57531914
90IRAK20.55717253
91MAP3K60.55618899
92HIPK20.55406497
93MAP3K30.54524386
94SGK30.53759037
95DDR20.53405705
96DYRK20.51653183
97RAF10.50484512
98NEK60.48948434
99DMPK0.48580780
100MOS0.48365054
101MAP3K130.47838235
102WNK40.46398504
103FYN0.46325289
104MAPKAPK30.45665885
105DYRK1A0.45468699
106RPS6KA30.44728134
107ROCK10.43994328
108FES0.42778830
109BRSK10.42724890
110SGK10.42691611
111CAMK2B0.41765895
112DAPK30.41264249
113TESK10.41042827
114PRKG20.40117641
115MAPK100.38899810
116PRKD10.38500314
117ROCK20.38386154
118CAMK2G0.37987527
119PRKCE0.37736755
120PRKAA10.35894162
121CAMK2D0.35371275
122MAP3K70.33160937

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047213.11604535
2Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.69390944
3Nicotine addiction_Homo sapiens_hsa050332.32151349
4Olfactory transduction_Homo sapiens_hsa047402.31225712
5Circadian entrainment_Homo sapiens_hsa047132.23599002
6GABAergic synapse_Homo sapiens_hsa047272.22286558
7Long-term potentiation_Homo sapiens_hsa047202.13993926
8Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.06006772
9Insulin secretion_Homo sapiens_hsa049112.00899867
10Glutamatergic synapse_Homo sapiens_hsa047242.00686462
11Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.95534506
12Morphine addiction_Homo sapiens_hsa050321.89223279
13* Dopaminergic synapse_Homo sapiens_hsa047281.85985088
14Amphetamine addiction_Homo sapiens_hsa050311.79935208
15Cholinergic synapse_Homo sapiens_hsa047251.79316642
16Salivary secretion_Homo sapiens_hsa049701.77257510
17Gastric acid secretion_Homo sapiens_hsa049711.74474806
18* Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.71935533
19Aldosterone synthesis and secretion_Homo sapiens_hsa049251.68527375
20Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.55292040
21Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.52943714
22Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.49630320
23Type II diabetes mellitus_Homo sapiens_hsa049301.46952531
24Oxytocin signaling pathway_Homo sapiens_hsa049211.45033514
25Gap junction_Homo sapiens_hsa045401.44212455
26Cocaine addiction_Homo sapiens_hsa050301.41977970
27GnRH signaling pathway_Homo sapiens_hsa049121.39913950
28Long-term depression_Homo sapiens_hsa047301.39484275
29Renin secretion_Homo sapiens_hsa049241.36074271
30Taste transduction_Homo sapiens_hsa047421.34905612
31Estrogen signaling pathway_Homo sapiens_hsa049151.30981246
32Glioma_Homo sapiens_hsa052141.30146240
33Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.24030571
34Nitrogen metabolism_Homo sapiens_hsa009101.22688826
35Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.19575870
36Serotonergic synapse_Homo sapiens_hsa047261.16586121
37Axon guidance_Homo sapiens_hsa043601.13129999
38Calcium signaling pathway_Homo sapiens_hsa040201.11711484
39Phosphatidylinositol signaling system_Homo sapiens_hsa040701.09302734
40cAMP signaling pathway_Homo sapiens_hsa040241.07360573
41ErbB signaling pathway_Homo sapiens_hsa040121.06206371
42Neurotrophin signaling pathway_Homo sapiens_hsa047221.02193138
43Carbohydrate digestion and absorption_Homo sapiens_hsa049730.97806511
44cGMP-PKG signaling pathway_Homo sapiens_hsa040220.96713548
45Phospholipase D signaling pathway_Homo sapiens_hsa040720.96659218
46Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.96654183
47Melanogenesis_Homo sapiens_hsa049160.96593746
48Dilated cardiomyopathy_Homo sapiens_hsa054140.96254309
49Dorso-ventral axis formation_Homo sapiens_hsa043200.93869188
50VEGF signaling pathway_Homo sapiens_hsa043700.91145055
51Collecting duct acid secretion_Homo sapiens_hsa049660.90521005
52Endometrial cancer_Homo sapiens_hsa052130.90462440
53mTOR signaling pathway_Homo sapiens_hsa041500.89337546
54Pancreatic secretion_Homo sapiens_hsa049720.88166690
55Cardiac muscle contraction_Homo sapiens_hsa042600.88039499
56Vascular smooth muscle contraction_Homo sapiens_hsa042700.86042537
57Vibrio cholerae infection_Homo sapiens_hsa051100.85734750
58Thyroid hormone synthesis_Homo sapiens_hsa049180.85681491
59Insulin signaling pathway_Homo sapiens_hsa049100.84261890
60Endocytosis_Homo sapiens_hsa041440.81591533
61Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.79294243
62Thyroid hormone signaling pathway_Homo sapiens_hsa049190.73664982
63Bile secretion_Homo sapiens_hsa049760.73425964
64* Oocyte meiosis_Homo sapiens_hsa041140.73127184
65Renal cell carcinoma_Homo sapiens_hsa052110.72370462
66Choline metabolism in cancer_Homo sapiens_hsa052310.71261451
67Glucagon signaling pathway_Homo sapiens_hsa049220.70265768
68Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.68439756
69Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.68295625
70Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.67008106
71Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.66804150
72MAPK signaling pathway_Homo sapiens_hsa040100.66532795
73Central carbon metabolism in cancer_Homo sapiens_hsa052300.66398397
74Notch signaling pathway_Homo sapiens_hsa043300.64215765
75Longevity regulating pathway - mammal_Homo sapiens_hsa042110.62667096
76Non-small cell lung cancer_Homo sapiens_hsa052230.60988638
77Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.60499196
78Prion diseases_Homo sapiens_hsa050200.60223818
79Rap1 signaling pathway_Homo sapiens_hsa040150.58644000
80AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.57665382
81Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.57103559
82Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.56930070
83Ras signaling pathway_Homo sapiens_hsa040140.56473826
84Chronic myeloid leukemia_Homo sapiens_hsa052200.55574366
85* Sphingolipid signaling pathway_Homo sapiens_hsa040710.55471057
86Amoebiasis_Homo sapiens_hsa051460.54807495
87HIF-1 signaling pathway_Homo sapiens_hsa040660.52267529
88Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.51689404
89Salmonella infection_Homo sapiens_hsa051320.51558622
90Alcoholism_Homo sapiens_hsa050340.50978274
91Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.50537922
92Prolactin signaling pathway_Homo sapiens_hsa049170.50260397
93Chemokine signaling pathway_Homo sapiens_hsa040620.50033906
94Inositol phosphate metabolism_Homo sapiens_hsa005620.48573947
95Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.48508831
96B cell receptor signaling pathway_Homo sapiens_hsa046620.47776050
97Colorectal cancer_Homo sapiens_hsa052100.47135986
98SNARE interactions in vesicular transport_Homo sapiens_hsa041300.46681195
99Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.46054196
100Tight junction_Homo sapiens_hsa045300.45485078
101Osteoclast differentiation_Homo sapiens_hsa043800.44542707
102Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.43789646
103Phagosome_Homo sapiens_hsa041450.43039238
104Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.43028900
105Acute myeloid leukemia_Homo sapiens_hsa052210.42853172
106Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.42585316
107Vitamin B6 metabolism_Homo sapiens_hsa007500.41882945
108Glycosaminoglycan degradation_Homo sapiens_hsa005310.41853236
109Insulin resistance_Homo sapiens_hsa049310.40713441
110Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.39366401
111* AMPK signaling pathway_Homo sapiens_hsa041520.38352886
112Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.36686975
113Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.35113300
114Adipocytokine signaling pathway_Homo sapiens_hsa049200.35043471
115Focal adhesion_Homo sapiens_hsa045100.34296627
116Circadian rhythm_Homo sapiens_hsa047100.34071483
1172-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.33701049

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