PPP2R5D

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The product of this gene belongs to the phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a delta isoform of the regulatory subunit B56 subfamily. Alternatively spliced transcript variants encoding different isoforms have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1COPI coating of Golgi vesicle (GO:0048205)5.50512807
2Golgi transport vesicle coating (GO:0048200)5.50512807
3peptidyl-arginine omega-N-methylation (GO:0035247)4.75725338
4proline biosynthetic process (GO:0006561)4.61042448
5protein localization to kinetochore (GO:0034501)4.35643251
6peptidyl-arginine methylation (GO:0018216)4.30989204
7peptidyl-arginine N-methylation (GO:0035246)4.30989204
8DNA unwinding involved in DNA replication (GO:0006268)4.27204220
9pre-miRNA processing (GO:0031054)4.18266634
10positive regulation of synapse maturation (GO:0090129)4.09292019
11establishment of integrated proviral latency (GO:0075713)4.08660852
12retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)4.07330585
13protein retention in ER lumen (GO:0006621)4.04539101
14protein maturation by protein folding (GO:0022417)4.03824532
15mitotic sister chromatid segregation (GO:0000070)4.00530059
16maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.98017410
17regulation of translational fidelity (GO:0006450)3.94842513
18regulation of mammary gland epithelial cell proliferation (GO:0033599)3.87836361
19sister chromatid segregation (GO:0000819)3.86987643
20histone arginine methylation (GO:0034969)3.71381221
21NADH metabolic process (GO:0006734)3.61557876
22regulation of translational termination (GO:0006449)3.54983740
23heterochromatin organization (GO:0070828)3.54643362
24regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.44214264
25negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.43506512
26nuclear pore complex assembly (GO:0051292)3.37344624
27mitotic metaphase plate congression (GO:0007080)3.36593170
28protein localization to chromosome, centromeric region (GO:0071459)3.36101240
29peptidyl-lysine dimethylation (GO:0018027)3.35131270
30spliceosomal tri-snRNP complex assembly (GO:0000244)3.31665899
31nuclear pore organization (GO:0006999)3.28377811
32establishment of viral latency (GO:0019043)3.27890027
33proline metabolic process (GO:0006560)3.25936230
34protein complex localization (GO:0031503)3.25875995
35layer formation in cerebral cortex (GO:0021819)3.25433149
36mitotic nuclear envelope reassembly (GO:0007084)3.25326117
37nuclear envelope reassembly (GO:0031468)3.25326117
38negative regulation of cell size (GO:0045792)3.23488880
39mitotic nuclear envelope disassembly (GO:0007077)3.22916659
40* glycolytic process (GO:0006096)3.16395565
41regulation of hippo signaling (GO:0035330)3.15976040
42membrane disassembly (GO:0030397)3.14975260
43nuclear envelope disassembly (GO:0051081)3.14975260
44regulation of gene silencing by RNA (GO:0060966)3.12019871
45regulation of posttranscriptional gene silencing (GO:0060147)3.12019871
46regulation of gene silencing by miRNA (GO:0060964)3.12019871
47synaptic vesicle maturation (GO:0016188)3.11864065
48establishment of nucleus localization (GO:0040023)3.11338642
49glucocorticoid receptor signaling pathway (GO:0042921)3.10298230
50formation of translation preinitiation complex (GO:0001731)3.09332347
51chromosome condensation (GO:0030261)3.09129858
52paraxial mesoderm development (GO:0048339)3.08343650
53mitotic chromosome condensation (GO:0007076)3.07566729
54DNA replication-dependent nucleosome assembly (GO:0006335)3.05431024
55DNA replication-dependent nucleosome organization (GO:0034723)3.05431024
56pore complex assembly (GO:0046931)3.04169403
57gluconeogenesis (GO:0006094)3.01793871
58DNA topological change (GO:0006265)2.99612440
59intracellular estrogen receptor signaling pathway (GO:0030520)2.99288592
60DNA strand elongation (GO:0022616)2.98293281
61dosage compensation (GO:0007549)2.97637671
62cellular protein complex localization (GO:0034629)2.92142551
63pentose-phosphate shunt (GO:0006098)2.89354547
64regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.87986950
65folic acid-containing compound biosynthetic process (GO:0009396)2.84350930
66vesicle coating (GO:0006901)2.83358429
67embryonic foregut morphogenesis (GO:0048617)2.82499817
68cytoskeletal anchoring at plasma membrane (GO:0007016)2.82333822
69negative regulation of histone methylation (GO:0031061)2.81819054
70negative regulation of microtubule polymerization (GO:0031115)2.81197604
71nucleobase-containing small molecule interconversion (GO:0015949)2.81071180
72monosaccharide biosynthetic process (GO:0046364)2.79403401
73DNA duplex unwinding (GO:0032508)2.79402813
74hexose biosynthetic process (GO:0019319)2.78639852
75locomotory exploration behavior (GO:0035641)2.77069301
76mitochondrial fusion (GO:0008053)2.75727124
77negative regulation of RNA splicing (GO:0033119)2.75685057
78DNA geometric change (GO:0032392)2.74762607
79negative regulation of telomerase activity (GO:0051974)2.73465090
80protein localization to endosome (GO:0036010)2.72534715
81NADPH regeneration (GO:0006740)2.69555756
82regulation of NFAT protein import into nucleus (GO:0051532)2.68781197
83L-serine metabolic process (GO:0006563)2.66782944
84positive regulation of nuclease activity (GO:0032075)2.66418900
85regulation of synapse structural plasticity (GO:0051823)2.65814933
86negative regulation of mRNA processing (GO:0050686)2.65779294
87mitotic G1 DNA damage checkpoint (GO:0031571)2.65390972
88hippo signaling (GO:0035329)2.61957359
89activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.61485203
90mitotic cytokinesis (GO:0000281)2.61327611
91tricarboxylic acid cycle (GO:0006099)2.60466896
92adherens junction assembly (GO:0034333)2.60230023
93lens fiber cell development (GO:0070307)2.59934649
94nucleosome disassembly (GO:0006337)2.59819049
95protein-DNA complex disassembly (GO:0032986)2.59819049
96nuclear envelope organization (GO:0006998)2.59761220
97planar cell polarity pathway involved in neural tube closure (GO:0090179)2.59335900
98nodal signaling pathway (GO:0038092)2.58244544
99glucose catabolic process (GO:0006007)2.58140198
100positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.58022026
101glucose 6-phosphate metabolic process (GO:0051156)2.57709491
102maternal placenta development (GO:0001893)2.57428898
103negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.56712456
104cytoskeleton-dependent cytokinesis (GO:0061640)2.54353344
105cell-substrate adherens junction assembly (GO:0007045)2.53757546
106focal adhesion assembly (GO:0048041)2.53757546
107regulation of mitotic spindle organization (GO:0060236)2.53261289
108telomere maintenance via semi-conservative replication (GO:0032201)2.53254317
109regulation of spindle organization (GO:0090224)2.52922546
110actin filament depolymerization (GO:0030042)2.52903294
111tricarboxylic acid metabolic process (GO:0072350)2.52783029
112IMP biosynthetic process (GO:0006188)2.52450027
113protein export from nucleus (GO:0006611)2.52214489
114positive regulation of RNA splicing (GO:0033120)2.52026036
115mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.50648649
116sodium ion export (GO:0071436)2.50586482
117activation of Rac GTPase activity (GO:0032863)2.50449830
118peptidyl-proline hydroxylation (GO:0019511)2.49667011
119apoptotic process involved in morphogenesis (GO:0060561)2.48797235
120regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.48713511
121regulation of sister chromatid cohesion (GO:0007063)2.48183416
122positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.47920450
123DNA packaging (GO:0006323)2.47616520
124barbed-end actin filament capping (GO:0051016)2.47550470
125regulation of early endosome to late endosome transport (GO:2000641)2.47312662
1264-hydroxyproline metabolic process (GO:0019471)2.47204393
127adenine nucleotide transport (GO:0051503)2.46944451
128establishment of chromosome localization (GO:0051303)2.46381394
129positive regulation of chromosome segregation (GO:0051984)2.46134990
130regulation of synapse maturation (GO:0090128)2.45554566
131polarized epithelial cell differentiation (GO:0030859)2.45208221
132NLS-bearing protein import into nucleus (GO:0006607)2.45000832
133metaphase plate congression (GO:0051310)2.44520763
134regulation of chromatin binding (GO:0035561)2.43706843
135collecting duct development (GO:0072044)2.43531471
136regulation of exit from mitosis (GO:0007096)2.43073576
137negative regulation of chromosome segregation (GO:0051985)2.42225498
138regulation of telomere maintenance via telomerase (GO:0032210)2.42215579
139synaptic vesicle docking involved in exocytosis (GO:0016081)2.41784341
140glutamine family amino acid biosynthetic process (GO:0009084)2.41581599
141positive regulation of DNA-dependent DNA replication (GO:2000105)2.41337394
142spindle assembly checkpoint (GO:0071173)2.41272994
143ribosome assembly (GO:0042255)2.41147499
144regulation of chromosome segregation (GO:0051983)2.40766336
145mitotic spindle assembly checkpoint (GO:0007094)2.40306197
146histone H4-K12 acetylation (GO:0043983)2.38947640
147histone H2A monoubiquitination (GO:0035518)2.38834135
148protein localization to chromosome (GO:0034502)2.38613491
149negative regulation of mRNA metabolic process (GO:1903312)2.36673093
150DNA replication initiation (GO:0006270)2.35611762
151cell migration in hindbrain (GO:0021535)2.35343179
152establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.35144091
153chromatin assembly (GO:0031497)2.35116264
154DNA strand elongation involved in DNA replication (GO:0006271)2.34526821
155mRNA stabilization (GO:0048255)2.34227357
156RNA stabilization (GO:0043489)2.34227357
157histone H4-K8 acetylation (GO:0043982)2.32990505
158histone H4-K5 acetylation (GO:0043981)2.32990505
159peptidyl-arginine modification (GO:0018195)2.32472343
160establishment of apical/basal cell polarity (GO:0035089)2.32098058
161cerebellar Purkinje cell layer development (GO:0021680)2.32088988

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.00430773
2FOXM1_23109430_ChIP-Seq_U2OS_Human5.26937387
3* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.05759444
4MYC_22102868_ChIP-Seq_BL_Human2.97509136
5ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.84156848
6ZFP281_18757296_ChIP-ChIP_E14_Mouse2.64742726
7E2F4_17652178_ChIP-ChIP_JURKAT_Human2.52957859
8MYC_18555785_ChIP-Seq_MESCs_Mouse2.50890390
9EGR1_19374776_ChIP-ChIP_THP-1_Human2.46143448
10* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.43864725
11FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.28807343
12NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.26631780
13MYC_19079543_ChIP-ChIP_MESCs_Mouse2.24493983
14ESR1_15608294_ChIP-ChIP_MCF-7_Human2.02580514
15ZFP281_27345836_Chip-Seq_ESCs_Mouse2.00054690
16PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.93391222
17POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.91455816
18KDM2B_26808549_Chip-Seq_DND41_Human1.86867464
19THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.86787512
20XRN2_22483619_ChIP-Seq_HELA_Human1.77564724
21AR_21909140_ChIP-Seq_LNCAP_Human1.77187321
22SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.76134292
23CLOCK_20551151_ChIP-Seq_293T_Human1.73736738
24KDM2B_26808549_Chip-Seq_SUP-B15_Human1.71987602
25CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.71047836
26* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.70633143
27SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.70430284
28RARG_19884340_ChIP-ChIP_MEFs_Mouse1.69831118
29WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.66464882
30KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.64464105
31NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.63034104
32VDR_21846776_ChIP-Seq_THP-1_Human1.60689508
33* LXR_22292898_ChIP-Seq_THP-1_Human1.60462720
34ELK3_25401928_ChIP-Seq_HUVEC_Human1.58298055
35KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.55527756
36TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.55073850
37MYC_19030024_ChIP-ChIP_MESCs_Mouse1.55051713
38ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.54124118
39SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.53561329
40KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.53171508
41JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.51868094
42* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.51591874
43CREB1_15753290_ChIP-ChIP_HEK293T_Human1.50944394
44CIITA_25753668_ChIP-Seq_RAJI_Human1.49658675
45MYC_18358816_ChIP-ChIP_MESCs_Mouse1.49219306
46KDM2B_26808549_Chip-Seq_K562_Human1.48208719
47RARB_27405468_Chip-Seq_BRAIN_Mouse1.47761465
48DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.47206801
49E2F1_18555785_ChIP-Seq_MESCs_Mouse1.45885972
50* MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.45567813
51KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.44546884
52ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.44148475
53TCF7_22412390_ChIP-Seq_EML_Mouse1.42379035
54ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.42102093
55NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.41863478
56E2F1_21310950_ChIP-Seq_MCF-7_Human1.41723714
57* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.39920790
58NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.38966477
59TET1_21451524_ChIP-Seq_MESCs_Mouse1.37951112
60KDM2B_26808549_Chip-Seq_JURKAT_Human1.37580003
61CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.37160908
62THAP11_20581084_ChIP-Seq_MESCs_Mouse1.36551289
63SRY_22984422_ChIP-ChIP_TESTIS_Rat1.36261107
64* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.36104158
65TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.35112681
66NANOG_18555785_ChIP-Seq_MESCs_Mouse1.34801065
67ZNF263_19887448_ChIP-Seq_K562_Human1.34540577
68KLF4_18555785_ChIP-Seq_MESCs_Mouse1.34096120
69SOX2_18555785_ChIP-Seq_MESCs_Mouse1.33831793
70DCP1A_22483619_ChIP-Seq_HELA_Human1.33495304
71* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.33059927
72MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.32767480
73* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.32512000
74HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.31492339
75* GABP_19822575_ChIP-Seq_HepG2_Human1.29961089
76SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.29787159
77TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.29169890
78P300_27058665_Chip-Seq_ZR-75-30cells_Human1.28942070
79NANOG_21062744_ChIP-ChIP_HESCs_Human1.28312395
80TP63_19390658_ChIP-ChIP_HaCaT_Human1.27983457
81CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.26322950
82TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.25830060
83TCF3_18692474_ChIP-Seq_MEFs_Mouse1.25734371
84ATF3_27146783_Chip-Seq_COLON_Human1.25391528
85P68_20966046_ChIP-Seq_HELA_Human1.24368727
86NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.24041922
87NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.24009687
88RACK7_27058665_Chip-Seq_MCF-7_Human1.23233461
89SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.22470742
90CREB1_26743006_Chip-Seq_LNCaP_Human1.20595787
91TP53_22127205_ChIP-Seq_IMR90_Human1.20239869
92TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.19877168
93HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.19836613
94ETS1_20019798_ChIP-Seq_JURKAT_Human1.18592019
95ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.18038282
96YY1_21170310_ChIP-Seq_MESCs_Mouse1.13785535
97DNAJC2_21179169_ChIP-ChIP_NT2_Human1.13369896
98KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.12341688
99PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.12179481
100POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.11745336
101MYCN_18555785_ChIP-Seq_MESCs_Mouse1.11682562
102UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.11163996
103POU5F1_16518401_ChIP-PET_MESCs_Mouse1.10688347
104* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.10353072
105NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.10191395
106HIF1A_21447827_ChIP-Seq_MCF-7_Human1.09791151
107PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.09089283
108MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.09050833
109SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.08922019
110ERG_21242973_ChIP-ChIP_JURKAT_Human1.08905151
111ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.08443237
112EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.08197079
113SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.07981417
114* OCT4_18692474_ChIP-Seq_MEFs_Mouse1.07596383
115SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.07593121
116* TBX5_21415370_ChIP-Seq_HL-1_Mouse1.07249579
117KDM5A_27292631_Chip-Seq_BREAST_Human1.05156229
118TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.04537815
119FOXP1_21924763_ChIP-Seq_HESCs_Human1.04521349
120TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse1.03988322
121CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.03398675
122CTCF_27219007_Chip-Seq_ERYTHROID_Human1.01999930
123STAT3_1855785_ChIP-Seq_MESCs_Mouse1.01787459
124TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.01385145
125YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.99880984
126TCF3_18692474_ChIP-Seq_MESCs_Mouse0.99174916
127* NCOR1_26117541_ChIP-Seq_K562_Human0.98250038
128TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.98207921
129TP63_17297297_ChIP-ChIP_HaCaT_Human0.97857386
130KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.97703605
131NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.97430142
132CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.97367564
133TTF2_22483619_ChIP-Seq_HELA_Human0.96655508
134SMC4_20622854_ChIP-Seq_HELA_Human0.95522194

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010030_abnormal_orbit_morphology4.18925529
2MP0004859_abnormal_synaptic_plasticity3.27490952
3MP0003705_abnormal_hypodermis_morpholog2.98677656
4MP0002877_abnormal_melanocyte_morpholog2.89785798
5MP0003123_paternal_imprinting2.85912924
6MP0005451_abnormal_body_composition2.72473154
7MP0003111_abnormal_nucleus_morphology2.64363527
8MP0002653_abnormal_ependyma_morphology2.48547246
9MP0003283_abnormal_digestive_organ2.34570664
10MP0005623_abnormal_meninges_morphology2.31598592
11MP0004957_abnormal_blastocyst_morpholog2.24246507
12MP0004858_abnormal_nervous_system2.19507811
13MP0005076_abnormal_cell_differentiation2.15715432
14MP0000537_abnormal_urethra_morphology2.09855935
15MP0008438_abnormal_cutaneous_collagen2.04973212
16MP0010352_gastrointestinal_tract_polyps2.04517009
17MP0001730_embryonic_growth_arrest2.04506249
18MP0003077_abnormal_cell_cycle2.03172443
19MP0004233_abnormal_muscle_weight2.02418611
20MP0003122_maternal_imprinting1.99970780
21MP0004272_abnormal_basement_membrane1.93884947
22MP0005423_abnormal_somatic_nervous1.87961183
23MP0003119_abnormal_digestive_system1.84056830
24MP0002084_abnormal_developmental_patter1.83227716
25MP0003121_genomic_imprinting1.82731117
26MP0003693_abnormal_embryo_hatching1.81238003
27MP0010094_abnormal_chromosome_stability1.80063383
28MP0005360_urolithiasis1.78471657
29MP0009780_abnormal_chondrocyte_physiolo1.78070422
30MP0002089_abnormal_postnatal_growth/wei1.77994352
31MP0000350_abnormal_cell_proliferation1.75025436
32MP0005257_abnormal_intraocular_pressure1.73178937
33MP0005058_abnormal_lysosome_morphology1.72606680
34MP0009053_abnormal_anal_canal1.64858932
35MP0004185_abnormal_adipocyte_glucose1.64830886
36MP0002085_abnormal_embryonic_tissue1.64382686
37MP0000749_muscle_degeneration1.62942037
38MP0008260_abnormal_autophagy1.62563124
39MP0000747_muscle_weakness1.62278393
40MP0001849_ear_inflammation1.61810293
41MP0004197_abnormal_fetal_growth/weight/1.58192301
42MP0003890_abnormal_embryonic-extraembry1.57422750
43MP0001672_abnormal_embryogenesis/_devel1.57404391
44MP0005380_embryogenesis_phenotype1.57404391
45MP0001697_abnormal_embryo_size1.55116411
46MP0000428_abnormal_craniofacial_morphol1.54615450
47MP0010234_abnormal_vibrissa_follicle1.52560603
48MP0001346_abnormal_lacrimal_gland1.50727388
49MP0003115_abnormal_respiratory_system1.49991109
50MP0003984_embryonic_growth_retardation1.48600776
51MP0002088_abnormal_embryonic_growth/wei1.46341927
52MP0003329_amyloid_beta_deposits1.44269575
53* MP0003635_abnormal_synaptic_transmissio1.44184403
54MP0008961_abnormal_basal_metabolism1.42555900
55MP0003861_abnormal_nervous_system1.39792341
56MP0002080_prenatal_lethality1.39678962
57MP0008932_abnormal_embryonic_tissue1.39661904
58MP0005501_abnormal_skin_physiology1.39391493
59MP0002086_abnormal_extraembryonic_tissu1.36860172
60MP0003880_abnormal_central_pattern1.34992629
61MP0009840_abnormal_foam_cell1.34746310
62MP0000534_abnormal_ureter_morphology1.31878496
63MP0000759_abnormal_skeletal_muscle1.27985246
64MP0003385_abnormal_body_wall1.27246080
65MP0000566_synostosis1.26322916
66MP0002249_abnormal_larynx_morphology1.25919814
67MP0000733_abnormal_muscle_development1.25897078
68MP0004811_abnormal_neuron_physiology1.25385361
69MP0005499_abnormal_olfactory_system1.23197295
70MP0005394_taste/olfaction_phenotype1.23197295
71MP0008007_abnormal_cellular_replicative1.22931776
72MP0003191_abnormal_cellular_cholesterol1.20809624
73MP0002063_abnormal_learning/memory/cond1.20369118
74MP0001915_intracranial_hemorrhage1.19219284
75MP0000678_abnormal_parathyroid_gland1.17944628
76MP0002822_catalepsy1.17109517
77MP0000569_abnormal_digit_pigmentation1.14934695
78MP0009697_abnormal_copulation1.14234168
79MP0010307_abnormal_tumor_latency1.14007132
80MP0004087_abnormal_muscle_fiber1.13045044
81MP0001293_anophthalmia1.12270214
82MP0002932_abnormal_joint_morphology1.08939043
83MP0002234_abnormal_pharynx_morphology1.06473448
84MP0003221_abnormal_cardiomyocyte_apopto1.06011792
85MP0001661_extended_life_span1.05446385
86MP0001348_abnormal_lacrimal_gland1.04718115
87MP0000955_abnormal_spinal_cord1.03953503
88MP0002152_abnormal_brain_morphology1.02362067
89MP0005621_abnormal_cell_physiology1.02313034
90MP0003935_abnormal_craniofacial_develop1.02059212
91MP0003942_abnormal_urinary_system1.01080343
92MP0008770_decreased_survivor_rate0.99185942
93MP0000013_abnormal_adipose_tissue0.98622185
94MP0000778_abnormal_nervous_system0.96497722
95MP0000049_abnormal_middle_ear0.96051850
96MP0002111_abnormal_tail_morphology0.95569814
97MP0010630_abnormal_cardiac_muscle0.93212638
98MP0009672_abnormal_birth_weight0.92986955
99MP0005409_darkened_coat_color0.92437748
100MP0000762_abnormal_tongue_morphology0.92087433
101MP0005248_abnormal_Harderian_gland0.92074690
102MP0005187_abnormal_penis_morphology0.91517924
103MP0003755_abnormal_palate_morphology0.90123743
104MP0002796_impaired_skin_barrier0.89835173
105MP0002081_perinatal_lethality0.88863615
106MP0005375_adipose_tissue_phenotype0.88647982
107MP0004133_heterotaxia0.86783953
108MP0003315_abnormal_perineum_morphology0.86290375
109MP0000490_abnormal_crypts_of0.86094577
110MP0005384_cellular_phenotype0.86024996
111MP0006138_congestive_heart_failure0.85253888
112MP0003567_abnormal_fetal_cardiomyocyte0.85011169
113MP0002184_abnormal_innervation0.84170284
114MP0005330_cardiomyopathy0.84161537
115MP0002092_abnormal_eye_morphology0.84021578
116MP0002925_abnormal_cardiovascular_devel0.83579112
117MP0005171_absent_coat_pigmentation0.81740385
118MP0002269_muscular_atrophy0.81336757
119MP0001299_abnormal_eye_distance/0.81257036
120MP0003091_abnormal_cell_migration0.81222913
121MP0002060_abnormal_skin_morphology0.80793871
122MP0003137_abnormal_impulse_conducting0.80725321
123MP0003937_abnormal_limbs/digits/tail_de0.79298338
124MP0008058_abnormal_DNA_repair0.79136891
125MP0000751_myopathy0.78750173
126MP0004264_abnormal_extraembryonic_tissu0.77260648
127MP0000003_abnormal_adipose_tissue0.77156879
128MP0002116_abnormal_craniofacial_bone0.77145776
129MP0008789_abnormal_olfactory_epithelium0.76848263
130MP0002114_abnormal_axial_skeleton0.76490735
131MP0000858_altered_metastatic_potential0.76013549
132MP0009703_decreased_birth_body0.74510473
133MP0003566_abnormal_cell_adhesion0.74468531
134MP0000358_abnormal_cell_content/0.73471420
135MP0002697_abnormal_eye_size0.73310690
136MP0002233_abnormal_nose_morphology0.72252413
137MP0008569_lethality_at_weaning0.72058846
138MP0005666_abnormal_adipose_tissue0.71622237
139MP0002909_abnormal_adrenal_gland0.71019659
140MP0000313_abnormal_cell_death0.69998058
141MP0003950_abnormal_plasma_membrane0.68794825
142MP0002970_abnormal_white_adipose0.68523531
143MP0009278_abnormal_bone_marrow0.68140286
144MP0004270_analgesia0.68125689
145MP0000750_abnormal_muscle_regeneration0.66008791
146MP0002396_abnormal_hematopoietic_system0.65142790

Predicted human phenotypes

RankGene SetZ-score
1Cholecystitis (HP:0001082)4.10692311
2Abnormal gallbladder physiology (HP:0012438)4.10692311
3Abnormality of the lower motor neuron (HP:0002366)3.53408373
4Premature rupture of membranes (HP:0001788)3.42236016
5Hyperacusis (HP:0010780)3.36775494
6Renal duplication (HP:0000075)3.30662733
7Ependymoma (HP:0002888)3.27524352
8Astrocytoma (HP:0009592)3.15093961
9Abnormality of the astrocytes (HP:0100707)3.15093961
10Pointed chin (HP:0000307)3.12854391
11Distal lower limb amyotrophy (HP:0008944)3.10349758
12Increased nuchal translucency (HP:0010880)3.08475964
13Protrusio acetabuli (HP:0003179)2.95942832
14Abnormality of glycolysis (HP:0004366)2.94369534
15Centrally nucleated skeletal muscle fibers (HP:0003687)2.91295171
16Short 4th metacarpal (HP:0010044)2.90360668
17Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.90360668
18Annular pancreas (HP:0001734)2.86630371
19Lower limb amyotrophy (HP:0007210)2.82320275
20Upper limb amyotrophy (HP:0009129)2.81054699
21Distal upper limb amyotrophy (HP:0007149)2.81054699
22Insomnia (HP:0100785)2.80230390
23Ankyloglossia (HP:0010296)2.79388137
24Shallow orbits (HP:0000586)2.77696776
25Hand muscle atrophy (HP:0009130)2.61664282
26Cortical dysplasia (HP:0002539)2.61339691
27Back pain (HP:0003418)2.54697958
28Amyotrophic lateral sclerosis (HP:0007354)2.52860619
29Increased connective tissue (HP:0009025)2.50224714
30Vertebral compression fractures (HP:0002953)2.47625665
31Abnormality of oral frenula (HP:0000190)2.44565796
32Myopathic facies (HP:0002058)2.44375538
33Increased serum pyruvate (HP:0003542)2.39918818
34Bowel diverticulosis (HP:0005222)2.38111570
35Abnormality of the 4th metacarpal (HP:0010012)2.37210721
36Selective tooth agenesis (HP:0001592)2.36194521
37Ulnar bowing (HP:0003031)2.34781430
38Abnormality of the umbilical cord (HP:0010881)2.33641591
39Elfin facies (HP:0004428)2.33400299
40Renovascular hypertension (HP:0100817)2.30525121
41Megalencephaly (HP:0001355)2.30519203
42Overriding aorta (HP:0002623)2.30399801
43Cerebral aneurysm (HP:0004944)2.28383767
44Ankle contracture (HP:0006466)2.27503550
45Glioma (HP:0009733)2.25756645
46Heterotopia (HP:0002282)2.21491610
47Single umbilical artery (HP:0001195)2.19952354
48Abnormality of the fetal cardiovascular system (HP:0010948)2.19952354
49Abnormal umbilical cord blood vessels (HP:0011403)2.19952354
50Broad face (HP:0000283)2.19634839
51Spinal rigidity (HP:0003306)2.17247547
52Biconcave vertebral bodies (HP:0004586)2.15127528
53Difficulty climbing stairs (HP:0003551)2.13709953
54Termporal pattern (HP:0011008)2.13534811
55Insidious onset (HP:0003587)2.13534811
56Disproportionate tall stature (HP:0001519)2.11924537
57Adenoma sebaceum (HP:0009720)2.09953778
58Angiofibromas (HP:0010615)2.09953778
59Hallux valgus (HP:0001822)2.07370552
60Deviation of the hallux (HP:0010051)2.06427463
61Distal lower limb muscle weakness (HP:0009053)2.05770774
62Upper limb muscle weakness (HP:0003484)2.05766398
63Genu recurvatum (HP:0002816)2.05541470
64Progressive muscle weakness (HP:0003323)2.05304626
65Resting tremor (HP:0002322)2.04023689
66Trigonocephaly (HP:0000243)2.03667230
67Myokymia (HP:0002411)2.03523008
68Deviation of the thumb (HP:0009603)2.02925592
69Cholelithiasis (HP:0001081)2.02668945
70Abnormality of the labia minora (HP:0012880)2.02562679
71Long palpebral fissure (HP:0000637)2.02065934
72Atrophy/Degeneration involving motor neurons (HP:0007373)2.01589718
73Neoplasm of the heart (HP:0100544)2.01250058
74Fibroma (HP:0010614)2.01236111
75Pseudobulbar signs (HP:0002200)2.00968257
76Bladder diverticulum (HP:0000015)2.00952090
77Proximal placement of thumb (HP:0009623)2.00607617
78Reticulocytosis (HP:0001923)1.99755864
79Neoplasm of striated muscle (HP:0009728)1.96874190
80Achilles tendon contracture (HP:0001771)1.96870012
81Exercise-induced myalgia (HP:0003738)1.92344001
82Intellectual disability, profound (HP:0002187)1.90612654
83Colon cancer (HP:0003003)1.90548696
84Megalocornea (HP:0000485)1.90498930
85Fibrous tissue neoplasm (HP:0012316)1.89939677
86Hammertoe (HP:0001765)1.89595203
87Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.89533059
88Uterine leiomyosarcoma (HP:0002891)1.88691076
89Leiomyosarcoma (HP:0100243)1.88691076
90High anterior hairline (HP:0009890)1.88599230
91Abnormal number of incisors (HP:0011064)1.88194492
92Medulloblastoma (HP:0002885)1.86855389
93Ragged-red muscle fibers (HP:0003200)1.86590713
94Gastrointestinal carcinoma (HP:0002672)1.85495282
95Malignant gastrointestinal tract tumors (HP:0006749)1.85495282
96Missing ribs (HP:0000921)1.84928313
97Obsessive-compulsive behavior (HP:0000722)1.83956812
98Sacral dimple (HP:0000960)1.83077270
99Supranuclear gaze palsy (HP:0000605)1.81940469
100Exercise-induced muscle cramps (HP:0003710)1.81437349
101Coronal craniosynostosis (HP:0004440)1.81242937
102Thin ribs (HP:0000883)1.80597663
103Limb-girdle muscle atrophy (HP:0003797)1.80410743
104Mildly elevated creatine phosphokinase (HP:0008180)1.79521371
105Abnormalities of placenta or umbilical cord (HP:0001194)1.78622191
106Broad thumb (HP:0011304)1.78586171
107Trismus (HP:0000211)1.78302863
108Orthostatic hypotension (HP:0001278)1.78153637
109Neonatal short-limb short stature (HP:0008921)1.76062959
110Deep palmar crease (HP:0006191)1.75821598
111Visual hallucinations (HP:0002367)1.74635374
112Wrist flexion contracture (HP:0001239)1.74014365
113Abnormality of the tricuspid valve (HP:0001702)1.73562964
114Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.72476429
115Abnormality of pain sensation (HP:0010832)1.72453613
116Impaired pain sensation (HP:0007328)1.72453613
117Flat cornea (HP:0007720)1.72009860
118Broad distal phalanx of finger (HP:0009836)1.71848408
119Lymphangioma (HP:0100764)1.71770499
120Skin tags (HP:0010609)1.71223943
121Breech presentation (HP:0001623)1.70916638
122Dysmetric saccades (HP:0000641)1.70915160
123Muscle stiffness (HP:0003552)1.70679351
124Abnormal gallbladder morphology (HP:0012437)1.70007349
125Neoplasm of the oral cavity (HP:0100649)1.69046498
126Abnormality of the musculature of the pelvis (HP:0001469)1.68837097
127Abnormality of the hip-girdle musculature (HP:0001445)1.68837097
128Distal sensory impairment (HP:0002936)1.68663966
129Growth hormone excess (HP:0000845)1.67624725
130Abnormality of the Achilles tendon (HP:0005109)1.67470289
131Rhabdomyosarcoma (HP:0002859)1.67319308
132Spastic diplegia (HP:0001264)1.66907865
133Abnormality of skeletal muscle fiber size (HP:0012084)1.66559015
134Microvesicular hepatic steatosis (HP:0001414)1.66321052
135Hypoplasia of the capital femoral epiphysis (HP:0003090)1.65915898
136Shoulder girdle muscle weakness (HP:0003547)1.64992047
137Abnormality of the musculature of the hand (HP:0001421)1.64467949
138Progressive external ophthalmoplegia (HP:0000590)1.63730155
139Preauricular skin tag (HP:0000384)1.61935746
140Asymmetry of the thorax (HP:0001555)1.61823193
141Generalized hypotonia (HP:0001290)1.61112378
142Pelvic girdle muscle weakness (HP:0003749)1.61059380
143Abnormality of the diencephalon (HP:0010662)1.60747589
144Broad palm (HP:0001169)1.60047671
145Abnormality of the calcaneus (HP:0008364)1.59063773
146Increased variability in muscle fiber diameter (HP:0003557)1.58434207
147Heterochromia iridis (HP:0001100)1.58371093
148Malignant neoplasm of the central nervous system (HP:0100836)1.58056600
149Abnormality of the gallbladder (HP:0005264)1.57411830
150Ankle clonus (HP:0011448)1.57074542
151Dilatation of the ascending aorta (HP:0005111)1.56446604
152Wormian bones (HP:0002645)1.56392506
153Increased density of long bones (HP:0006392)1.56181630
154Atresia of the external auditory canal (HP:0000413)1.55986601
155Reduced subcutaneous adipose tissue (HP:0003758)1.55776186
156Attention deficit hyperactivity disorder (HP:0007018)1.55739106
157Flat acetabular roof (HP:0003180)1.55255429
158Short nail (HP:0001799)1.55061226
159Microglossia (HP:0000171)1.52875749
160Generalized amyotrophy (HP:0003700)1.52613428
161Abnormality of the distal phalanges of the toes (HP:0010182)1.52605533
162Abnormal neuron morphology (HP:0012757)1.52214019
163Abnormality of the motor neurons (HP:0002450)1.52214019
164Bilateral microphthalmos (HP:0007633)1.51662061
165Broad phalanges of the hand (HP:0009768)1.51315289
166Calcaneovalgus deformity (HP:0001848)1.51095308
167Skull defect (HP:0001362)1.50490673
168Broad toe (HP:0001837)1.50358906
169Bladder neoplasm (HP:0009725)1.50352062
170Bladder carcinoma (HP:0002862)1.50352062
171Transitional cell carcinoma of the bladder (HP:0006740)1.50235028
172Osteolytic defects of the hand bones (HP:0009699)1.49634070
173Osteolytic defects of the phalanges of the hand (HP:0009771)1.49634070
174Deep venous thrombosis (HP:0002625)1.48482807
175Cerebral inclusion bodies (HP:0100314)1.48308377
176Rough bone trabeculation (HP:0100670)1.47813283
177Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.47510182

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB13.34385626
2TRIB33.31350314
3SMG13.23031110
4NEK13.16276460
5EEF2K3.15931023
6MAP3K102.70122277
7CDK122.69039545
8PKN22.45978345
9CDC72.40665087
10PRPF4B2.14038675
11LATS22.11326679
12MAP3K92.06849489
13NME22.03451015
14SCYL21.94379787
15ARAF1.93094519
16NEK21.88686086
17PDGFRA1.83057318
18TESK21.77827350
19KSR11.77166151
20KSR21.75469367
21TYRO31.70022864
22ICK1.67927665
23PAK61.67322504
24VRK21.67185489
25SRPK11.64210462
26ALK1.60282390
27IRAK31.55720718
28RIPK11.53673223
29TAOK11.51776047
30CAMKK11.42991431
31TTN1.38586904
32BRAF1.35300581
33PAK41.34453439
34MINK11.33304728
35PBK1.31652106
36EIF2AK11.26637774
37PRKD31.23511994
38TTK1.22612182
39BMX1.22488935
40NTRK21.22359938
41FGFR11.18718844
42DDR21.17940322
43SIK21.15679186
44FGFR41.14957054
45UHMK11.13189268
46EPHA41.12393046
47TAOK21.08702004
48BRSK11.06089840
49CDK151.02931313
50CCNB11.01664201
51CDK181.01619467
52WEE11.01349672
53MTOR1.00994018
54PIM20.99708407
55MAP3K80.97182731
56CDK11A0.96702959
57RPS6KB20.94271544
58PLK10.94066650
59CDK40.93805143
60MAP2K30.93489732
61CDK140.92097441
62CDK80.90673780
63GRK60.89510059
64LMTK20.87754147
65TSSK60.87328518
66MARK10.87013427
67NTRK30.86206061
68KDR0.83916536
69MAP3K40.83606581
70AKT20.80320965
71* CHEK10.79887885
72TESK10.79467887
73DAPK10.79074549
74LRRK20.78436830
75MST1R0.76516357
76ERN10.75923956
77PTK60.75120540
78CDK70.74921481
79BRD40.74870158
80PAK20.74101887
81CDK20.72985610
82RAF10.71543885
83STK380.69016386
84MAP3K60.68667974
85CDK90.67742377
86NTRK10.67638694
87ILK0.67590545
88AURKA0.67294793
89MAP2K70.67199161
90TLK10.65580808
91MOS0.63320114
92ERBB20.62726805
93SIK30.60862501
94PTK20.60626713
95RET0.59831490
96TGFBR10.59394985
97ATR0.58793859
98SIK10.58577764
99EPHB20.58467587
100AURKB0.56440613
101CHEK20.55397207
102STK100.55016054
103DAPK20.54408815
104CLK10.53681357
105CDK60.53632047
106FGFR30.53340657
107PASK0.52251263
108LIMK10.52221644
109TRIM280.49903928
110CDK50.49886257
111PLK30.49695831
112CDK10.49565368
113EPHA20.48510059
114MAP3K30.46912103
115CSNK1E0.46636705
116ERBB40.46354541
117MET0.45042275
118PAK10.44984684
119ACVR1B0.44025661
120MAPK110.43946308
121CAMK1D0.42817713
122DMPK0.42744740
123ROCK20.42388111
124MAP3K110.42245713
125MARK20.41707148
126PRKG20.41426885
127RPS6KA20.41280129
128ROCK10.41147798
129EPHB10.41042143
130DAPK30.40870834
131BCKDK0.40620854
132PHKG10.39616389
133PHKG20.39616389
134CDK190.39137477
135MAP3K70.38551494

Predicted pathways (KEGG)

RankGene SetZ-score
1Pentose phosphate pathway_Homo sapiens_hsa000302.24368307
2DNA replication_Homo sapiens_hsa030302.17975330
3RNA transport_Homo sapiens_hsa030131.87101374
4Spliceosome_Homo sapiens_hsa030401.85501405
5Cell cycle_Homo sapiens_hsa041101.81796084
6Fructose and mannose metabolism_Homo sapiens_hsa000511.77093187
7Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.75502167
8Hippo signaling pathway_Homo sapiens_hsa043901.73026027
9Basal cell carcinoma_Homo sapiens_hsa052171.71807802
10Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.65908400
11* Oocyte meiosis_Homo sapiens_hsa041141.64211868
12Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.62331069
13Vibrio cholerae infection_Homo sapiens_hsa051101.60529678
14* mRNA surveillance pathway_Homo sapiens_hsa030151.57530582
15Galactose metabolism_Homo sapiens_hsa000521.57268097
16Central carbon metabolism in cancer_Homo sapiens_hsa052301.57132824
17mTOR signaling pathway_Homo sapiens_hsa041501.52141079
18Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.50764593
192-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.50728605
20Bladder cancer_Homo sapiens_hsa052191.50664236
21Mismatch repair_Homo sapiens_hsa034301.46459086
22Colorectal cancer_Homo sapiens_hsa052101.46388525
23Biosynthesis of amino acids_Homo sapiens_hsa012301.45588823
24Arginine biosynthesis_Homo sapiens_hsa002201.44181206
25Hedgehog signaling pathway_Homo sapiens_hsa043401.43609636
26Sulfur relay system_Homo sapiens_hsa041221.41920439
27Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.39038973
28Glioma_Homo sapiens_hsa052141.38371057
29Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.37653765
30Gap junction_Homo sapiens_hsa045401.35090490
31Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.33549280
32Endometrial cancer_Homo sapiens_hsa052131.32082115
33Chronic myeloid leukemia_Homo sapiens_hsa052201.31010676
34Thyroid hormone signaling pathway_Homo sapiens_hsa049191.30220542
35MicroRNAs in cancer_Homo sapiens_hsa052061.28411608
36Non-small cell lung cancer_Homo sapiens_hsa052231.28065968
37Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.26595985
38Long-term potentiation_Homo sapiens_hsa047201.25773358
39Pyruvate metabolism_Homo sapiens_hsa006201.25498878
40Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.24386439
41Base excision repair_Homo sapiens_hsa034101.24319596
42Notch signaling pathway_Homo sapiens_hsa043301.20610291
43Synaptic vesicle cycle_Homo sapiens_hsa047211.20385608
44Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.18910347
45Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.18718600
46One carbon pool by folate_Homo sapiens_hsa006701.17756936
47Thyroid cancer_Homo sapiens_hsa052161.17080977
48Fatty acid elongation_Homo sapiens_hsa000621.14519732
49Nitrogen metabolism_Homo sapiens_hsa009101.12796010
50Proteoglycans in cancer_Homo sapiens_hsa052051.11739714
51Neurotrophin signaling pathway_Homo sapiens_hsa047221.10851759
52VEGF signaling pathway_Homo sapiens_hsa043701.09008795
53Olfactory transduction_Homo sapiens_hsa047401.07505300
54* Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.06556608
55Arginine and proline metabolism_Homo sapiens_hsa003301.06239324
56N-Glycan biosynthesis_Homo sapiens_hsa005101.06063411
57Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.05724956
58Other glycan degradation_Homo sapiens_hsa005111.05269418
59Adherens junction_Homo sapiens_hsa045201.04120156
60Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.02583773
61Melanogenesis_Homo sapiens_hsa049161.02265125
62Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.98203355
63Proteasome_Homo sapiens_hsa030500.97865482
64Wnt signaling pathway_Homo sapiens_hsa043100.95896662
65Estrogen signaling pathway_Homo sapiens_hsa049150.95887369
66Folate biosynthesis_Homo sapiens_hsa007900.95411452
67HTLV-I infection_Homo sapiens_hsa051660.95187180
68* Dopaminergic synapse_Homo sapiens_hsa047280.94934518
69Shigellosis_Homo sapiens_hsa051310.90214417
70GnRH signaling pathway_Homo sapiens_hsa049120.89875924
71Prion diseases_Homo sapiens_hsa050200.89516460
72p53 signaling pathway_Homo sapiens_hsa041150.89207335
73Tight junction_Homo sapiens_hsa045300.89014346
74Cysteine and methionine metabolism_Homo sapiens_hsa002700.88364859
75Oxytocin signaling pathway_Homo sapiens_hsa049210.88066516
76GABAergic synapse_Homo sapiens_hsa047270.86295552
77Circadian entrainment_Homo sapiens_hsa047130.86055866
78ErbB signaling pathway_Homo sapiens_hsa040120.83394349
79Alcoholism_Homo sapiens_hsa050340.82805975
80Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.82350045
81Small cell lung cancer_Homo sapiens_hsa052220.82342817
82Dorso-ventral axis formation_Homo sapiens_hsa043200.81817818
83Vitamin B6 metabolism_Homo sapiens_hsa007500.80863207
84Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.80775745
85Nicotine addiction_Homo sapiens_hsa050330.79412834
86Insulin signaling pathway_Homo sapiens_hsa049100.79241814
87Axon guidance_Homo sapiens_hsa043600.78713333
88Glutamatergic synapse_Homo sapiens_hsa047240.78527377
89Focal adhesion_Homo sapiens_hsa045100.78252871
90Rap1 signaling pathway_Homo sapiens_hsa040150.77970862
91Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.77839852
92Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.77777737
93Longevity regulating pathway - mammal_Homo sapiens_hsa042110.76667542
94Nucleotide excision repair_Homo sapiens_hsa034200.76537236
95Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.76533397
96Pyrimidine metabolism_Homo sapiens_hsa002400.75937778
97Renal cell carcinoma_Homo sapiens_hsa052110.75381107
98Aldosterone synthesis and secretion_Homo sapiens_hsa049250.75310736
99Viral carcinogenesis_Homo sapiens_hsa052030.74747923
100Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.74218690
101Cholinergic synapse_Homo sapiens_hsa047250.73422513
102Dilated cardiomyopathy_Homo sapiens_hsa054140.72904215
103Amphetamine addiction_Homo sapiens_hsa050310.72789496
104Carbon metabolism_Homo sapiens_hsa012000.71186708
105HIF-1 signaling pathway_Homo sapiens_hsa040660.69752052
106Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.69205048
107Pathways in cancer_Homo sapiens_hsa052000.67778093
108Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.66222855
109Pancreatic cancer_Homo sapiens_hsa052120.65808541
110Cyanoamino acid metabolism_Homo sapiens_hsa004600.65199866
111Renin-angiotensin system_Homo sapiens_hsa046140.64953521
112Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.63990901
113Morphine addiction_Homo sapiens_hsa050320.63802620
114Cocaine addiction_Homo sapiens_hsa050300.63272969
115Phospholipase D signaling pathway_Homo sapiens_hsa040720.63186485
116Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.62426974
117Gastric acid secretion_Homo sapiens_hsa049710.62212140
118Viral myocarditis_Homo sapiens_hsa054160.61874019
119Endocytosis_Homo sapiens_hsa041440.61358651
120Regulation of actin cytoskeleton_Homo sapiens_hsa048100.61036085
121* AMPK signaling pathway_Homo sapiens_hsa041520.60884667
122Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.60859064
123Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.60259792
124Lysine degradation_Homo sapiens_hsa003100.59747364
125TGF-beta signaling pathway_Homo sapiens_hsa043500.58046306
126Long-term depression_Homo sapiens_hsa047300.57464562
127Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.56566201
128Glucagon signaling pathway_Homo sapiens_hsa049220.56222021
129Fatty acid metabolism_Homo sapiens_hsa012120.55709922
130Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.52959147
131Acute myeloid leukemia_Homo sapiens_hsa052210.50727549
132Steroid biosynthesis_Homo sapiens_hsa001000.50027010
133Salmonella infection_Homo sapiens_hsa051320.47043958
134Phenylalanine metabolism_Homo sapiens_hsa003600.43001181
135Non-homologous end-joining_Homo sapiens_hsa034500.39861907
136Apoptosis_Homo sapiens_hsa042100.38886470

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