PPP2R5E

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the phosphatase 2A regulatory subunit B family. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes an epsilon isoform of the regulatory subunit B56 subfamily. Multiple transcript variants encoding several different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)4.72619216
2vocalization behavior (GO:0071625)4.56749016
3locomotory exploration behavior (GO:0035641)4.53951753
4positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.41595177
5neuron cell-cell adhesion (GO:0007158)4.39055511
6regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.31129003
7mitotic sister chromatid cohesion (GO:0007064)4.29502580
8synaptic vesicle maturation (GO:0016188)4.29090405
9positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.21484156
10pyrimidine nucleobase catabolic process (GO:0006208)4.16666226
11layer formation in cerebral cortex (GO:0021819)4.14760757
12regulation of glutamate receptor signaling pathway (GO:1900449)4.09385913
13synaptic vesicle exocytosis (GO:0016079)4.00504048
14gamma-aminobutyric acid transport (GO:0015812)3.97825657
15ionotropic glutamate receptor signaling pathway (GO:0035235)3.88433249
16exploration behavior (GO:0035640)3.86870945
17nucleobase catabolic process (GO:0046113)3.84115065
18dendritic spine morphogenesis (GO:0060997)3.82497152
19neurotransmitter secretion (GO:0007269)3.82075384
20glutamate secretion (GO:0014047)3.80286075
21neuron recognition (GO:0008038)3.76119036
22regulation of synaptic vesicle exocytosis (GO:2000300)3.74601103
23mating behavior (GO:0007617)3.69546902
24protein localization to synapse (GO:0035418)3.65448287
25regulation of long-term neuronal synaptic plasticity (GO:0048169)3.61066138
26glutamate receptor signaling pathway (GO:0007215)3.44890698
27dendrite morphogenesis (GO:0048813)3.40946024
28regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.32189222
29regulation of synaptic vesicle transport (GO:1902803)3.29823914
30regulation of neuronal synaptic plasticity (GO:0048168)3.27288310
31proline transport (GO:0015824)3.27201273
32activation of protein kinase A activity (GO:0034199)3.26372597
33axonal fasciculation (GO:0007413)3.24953317
34positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.21853965
35positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.21853965
36positive regulation of mitotic sister chromatid separation (GO:1901970)3.21853965
37negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.20039871
38negative regulation of translation, ncRNA-mediated (GO:0040033)3.20039871
39regulation of translation, ncRNA-mediated (GO:0045974)3.20039871
40prepulse inhibition (GO:0060134)3.13010638
41presynaptic membrane organization (GO:0097090)3.12391643
42cellular potassium ion homeostasis (GO:0030007)3.11184388
43neurotransmitter transport (GO:0006836)3.09601236
44negative regulation of DNA-dependent DNA replication (GO:2000104)3.06173126
45kinetochore organization (GO:0051383)3.05528624
46regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.05485310
47neurotransmitter-gated ion channel clustering (GO:0072578)3.03259460
48neuron-neuron synaptic transmission (GO:0007270)3.02815317
49neuronal action potential propagation (GO:0019227)3.02087566
50regulation of dendritic spine morphogenesis (GO:0061001)3.01833383
51sodium ion export (GO:0071436)3.01054545
52prenylation (GO:0097354)2.99085620
53protein prenylation (GO:0018342)2.99085620
54limb bud formation (GO:0060174)2.97464184
55synaptic transmission, glutamatergic (GO:0035249)2.95607515
56long-term memory (GO:0007616)2.91917401
57transmission of nerve impulse (GO:0019226)2.90374139
58central nervous system projection neuron axonogenesis (GO:0021952)2.89779273
59regulation of neurotransmitter levels (GO:0001505)2.89466979
60regulation of excitatory postsynaptic membrane potential (GO:0060079)2.85286386
61social behavior (GO:0035176)2.85279078
62intraspecies interaction between organisms (GO:0051703)2.85279078
63regulation of DNA endoreduplication (GO:0032875)2.83244715
64acrosome assembly (GO:0001675)2.82725401
65DNA double-strand break processing (GO:0000729)2.82509320
66G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.81841391
67regulation of synapse structural plasticity (GO:0051823)2.81667986
68chromatin remodeling at centromere (GO:0031055)2.79474949
69regulation of vesicle fusion (GO:0031338)2.78241163
70metaphase plate congression (GO:0051310)2.77947431
71synaptic vesicle endocytosis (GO:0048488)2.77334311
72kidney morphogenesis (GO:0060993)2.77230978
73regulation of postsynaptic membrane potential (GO:0060078)2.75791326
74erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.74749594
75L-phenylalanine catabolic process (GO:0006559)2.74749594
76positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.71733706
77kinetochore assembly (GO:0051382)2.70833779
78cell migration in hindbrain (GO:0021535)2.70704131
79CENP-A containing nucleosome assembly (GO:0034080)2.69897602
80synaptic vesicle docking involved in exocytosis (GO:0016081)2.69755131
81righting reflex (GO:0060013)2.68860930
82glutamate metabolic process (GO:0006536)2.68794451
83mitotic metaphase plate congression (GO:0007080)2.67699897
84positive regulation of synapse maturation (GO:0090129)2.67601739
85cerebellar granule cell differentiation (GO:0021707)2.66501983
86regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.66192919
87dicarboxylic acid biosynthetic process (GO:0043650)2.65707578
88synapse assembly (GO:0007416)2.64948346
89gamma-aminobutyric acid signaling pathway (GO:0007214)2.64709212
90regulation of centriole replication (GO:0046599)2.63983176
91positive regulation of dendritic spine morphogenesis (GO:0061003)2.63803800
92vesicle transport along microtubule (GO:0047496)2.62685151
93behavioral defense response (GO:0002209)2.62642175
94behavioral fear response (GO:0001662)2.62642175
95atrial cardiac muscle cell action potential (GO:0086014)2.62408234
96keratinocyte development (GO:0003334)2.61473187
97response to histamine (GO:0034776)2.61434418
98positive regulation of membrane potential (GO:0045838)2.60663132
99neuromuscular process controlling balance (GO:0050885)2.59352074
100sister chromatid segregation (GO:0000819)2.57997571
101regulation of cAMP-dependent protein kinase activity (GO:2000479)2.57821812
102regulation of dendritic spine development (GO:0060998)2.57395332
103presynaptic membrane assembly (GO:0097105)2.56586195
104regulation of clathrin-mediated endocytosis (GO:2000369)2.56158917
105cerebellar Purkinje cell differentiation (GO:0021702)2.54372160
106positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.53339541
107negative regulation of synaptic transmission, GABAergic (GO:0032229)2.53303399
108regulation of synaptic plasticity (GO:0048167)2.52551608
109histone exchange (GO:0043486)2.52233363
110postsynaptic membrane organization (GO:0001941)2.51709741
111organelle transport along microtubule (GO:0072384)2.51235304
112synapse organization (GO:0050808)2.51030851
113behavioral response to cocaine (GO:0048148)2.50939316
114long-term synaptic potentiation (GO:0060291)2.50663497
115negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.50592131
116negative regulation of cell killing (GO:0031342)2.50592131
117otic vesicle formation (GO:0030916)2.50195414
118neuromuscular process controlling posture (GO:0050884)2.49996245
119regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.49825585
120regulation of synaptic transmission, glutamatergic (GO:0051966)2.49096229
121learning (GO:0007612)2.48290142
122paraxial mesoderm development (GO:0048339)2.48284312
123replication fork processing (GO:0031297)2.48092929
124pre-miRNA processing (GO:0031054)2.47944716
125regulation of mitotic metaphase/anaphase transition (GO:0030071)2.47841941
126regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.47841941
127positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.47635470
128protein localization to kinetochore (GO:0034501)2.47010263
129innervation (GO:0060384)2.46808862
130regulation of neurotransmitter secretion (GO:0046928)2.46714060
131generation of neurons (GO:0048699)2.45419543
132cellular ketone body metabolic process (GO:0046950)2.45244327
133negative regulation of keratinocyte proliferation (GO:0010839)2.44841334
134auditory behavior (GO:0031223)2.44591640
135cellular sodium ion homeostasis (GO:0006883)2.43576314
136regulation of sister chromatid cohesion (GO:0007063)2.43125986
137spindle checkpoint (GO:0031577)2.42685390
138regulation of mitotic sister chromatid segregation (GO:0033047)2.42343409
139regulation of sister chromatid segregation (GO:0033045)2.42343409
140regulation of mitotic sister chromatid separation (GO:0010965)2.42343409
141membrane depolarization during action potential (GO:0086010)2.42062822
142fear response (GO:0042596)2.41825647
143microtubule anchoring (GO:0034453)2.41446616
144regulation of Rac protein signal transduction (GO:0035020)2.40832750
145non-recombinational repair (GO:0000726)2.39847036
146double-strand break repair via nonhomologous end joining (GO:0006303)2.39847036
147regulation of nuclear cell cycle DNA replication (GO:0033262)2.39414108
148positive regulation of chromosome segregation (GO:0051984)2.39377181
149mitotic spindle checkpoint (GO:0071174)2.32361056
150regulation of growth hormone secretion (GO:0060123)2.31185990
151DNA damage response, detection of DNA damage (GO:0042769)2.30681914
152olfactory bulb development (GO:0021772)2.30661802
153cerebral cortex radially oriented cell migration (GO:0021799)2.30478653
154intraciliary transport (GO:0042073)2.30264186
155DNA replication-independent nucleosome organization (GO:0034724)2.29422733
156DNA replication-independent nucleosome assembly (GO:0006336)2.29422733
157negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.27201901
158neuron fate determination (GO:0048664)2.25555643
159retinal ganglion cell axon guidance (GO:0031290)2.25332827
160regulation of keratinocyte proliferation (GO:0010837)2.24714739
161lateral sprouting from an epithelium (GO:0060601)2.24391910
162female gonad development (GO:0008585)2.24162844
163response to X-ray (GO:0010165)2.23143700
164sister chromatid cohesion (GO:0007062)2.22942630
165resolution of meiotic recombination intermediates (GO:0000712)2.22895516
166negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.22481779
167negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.22481779
168negative regulation of mitotic sister chromatid segregation (GO:0033048)2.22481779
169negative regulation of mitotic sister chromatid separation (GO:2000816)2.22481779
170negative regulation of sister chromatid segregation (GO:0033046)2.22481779
171mitotic sister chromatid segregation (GO:0000070)2.21914372
172attachment of spindle microtubules to kinetochore (GO:0008608)2.21821004
173DNA topological change (GO:0006265)2.21039393
174somite rostral/caudal axis specification (GO:0032525)2.20506675
175organ growth (GO:0035265)2.20105658
176regulation of telomere maintenance (GO:0032204)2.19584935
177positive regulation of mRNA processing (GO:0050685)2.19493493
178intestinal epithelial cell development (GO:0060576)2.18298240
179regulation of meiosis I (GO:0060631)2.18039013
180DNA ligation (GO:0006266)2.17337034
181establishment of integrated proviral latency (GO:0075713)2.16904185
182telomere maintenance via telomerase (GO:0007004)2.16838155
183regulation of chromosome segregation (GO:0051983)2.15728621
184negative regulation of chromosome segregation (GO:0051985)2.15483658
185sympathetic nervous system development (GO:0048485)2.14852009
186negative regulation of DNA recombination (GO:0045910)2.14756220
187regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.14112080
188maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.13560589
189negative regulation of dendrite development (GO:2000171)2.13267215
190establishment of chromosome localization (GO:0051303)2.13067186
191mitotic G2/M transition checkpoint (GO:0044818)2.13041248

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.14534768
2SALL1_21062744_ChIP-ChIP_HESCs_Human3.82063968
3RBPJ_22232070_ChIP-Seq_NCS_Mouse3.38661737
4GBX2_23144817_ChIP-Seq_PC3_Human2.98067405
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.48427646
6SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.47246709
7JARID2_20064375_ChIP-Seq_MESCs_Mouse2.41730374
8EWS_26573619_Chip-Seq_HEK293_Human2.28802309
9ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.23588590
10GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.22563568
11RNF2_18974828_ChIP-Seq_MESCs_Mouse2.21899838
12EZH2_18974828_ChIP-Seq_MESCs_Mouse2.21899838
13TAF15_26573619_Chip-Seq_HEK293_Human2.18249668
14REST_21632747_ChIP-Seq_MESCs_Mouse2.15351139
15MTF2_20144788_ChIP-Seq_MESCs_Mouse2.14287668
16SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.14261016
17NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.12294872
18SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.11691722
19JARID2_20075857_ChIP-Seq_MESCs_Mouse2.07578579
20HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.07545666
21FLI1_27457419_Chip-Seq_LIVER_Mouse2.03903027
22AR_21572438_ChIP-Seq_LNCaP_Human2.02612597
23SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.02280068
24EZH2_27304074_Chip-Seq_ESCs_Mouse2.01108620
25SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.00914410
26SUZ12_27294783_Chip-Seq_ESCs_Mouse1.92162663
27* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.88409021
28FOXM1_23109430_ChIP-Seq_U2OS_Human1.88254745
29DROSHA_22980978_ChIP-Seq_HELA_Human1.86718370
30EZH2_27294783_Chip-Seq_ESCs_Mouse1.86390902
31CTBP2_25329375_ChIP-Seq_LNCAP_Human1.85293606
32RNF2_27304074_Chip-Seq_ESCs_Mouse1.82134391
33RARB_27405468_Chip-Seq_BRAIN_Mouse1.81567997
34EED_16625203_ChIP-ChIP_MESCs_Mouse1.77766415
35PCGF2_27294783_Chip-Seq_ESCs_Mouse1.74665187
36E2F4_17652178_ChIP-ChIP_JURKAT_Human1.72671489
37REST_18959480_ChIP-ChIP_MESCs_Mouse1.68808162
38CTBP1_25329375_ChIP-Seq_LNCAP_Human1.66669511
39MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.66312225
40POU5F1_16153702_ChIP-ChIP_HESCs_Human1.64516266
41ZNF274_21170338_ChIP-Seq_K562_Hela1.64029006
42SMAD4_21799915_ChIP-Seq_A2780_Human1.61839083
43CDX2_19796622_ChIP-Seq_MESCs_Mouse1.55853835
44MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.55678514
45PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.53647700
46ELK1_19687146_ChIP-ChIP_HELA_Human1.51607433
47SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.48527310
48WT1_19549856_ChIP-ChIP_CCG9911_Human1.47565997
49HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.41780088
50SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.39696453
51P300_19829295_ChIP-Seq_ESCs_Human1.38630880
52NANOG_18555785_Chip-Seq_ESCs_Mouse1.37337550
53CBX2_27304074_Chip-Seq_ESCs_Mouse1.37055792
54SUZ12_27294783_Chip-Seq_NPCs_Mouse1.36850580
55CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.36497807
56ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.33171905
57ZNF217_24962896_ChIP-Seq_MCF-7_Human1.33131288
58FOXM1_26456572_ChIP-Seq_MCF-7_Human1.32042639
59EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.32024444
60TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.31288708
61EZH2_27294783_Chip-Seq_NPCs_Mouse1.31057969
62SMAD3_21741376_ChIP-Seq_EPCs_Human1.30118246
63AR_21909140_ChIP-Seq_LNCAP_Human1.29473454
64ZFP57_27257070_Chip-Seq_ESCs_Mouse1.28860080
65SOX2_21211035_ChIP-Seq_LN229_Gbm1.28794667
66PCGF2_27294783_Chip-Seq_NPCs_Mouse1.28012552
67KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.26903109
68RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.26874723
69STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.26410950
70MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.26322715
71EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.24217411
72BCAT_22108803_ChIP-Seq_LS180_Human1.23976798
73PIAS1_25552417_ChIP-Seq_VCAP_Human1.23779812
74CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.23170801
75TOP2B_26459242_ChIP-Seq_MCF-7_Human1.22672054
76AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.22557892
77* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.22363151
78PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.21987997
79* AR_25329375_ChIP-Seq_VCAP_Human1.21582697
80TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.20811089
81RING1B_27294783_Chip-Seq_ESCs_Mouse1.19108396
82IKZF1_21737484_ChIP-ChIP_HCT116_Human1.18514610
83KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.18391576
84* TBX3_20139965_ChIP-Seq_MESCs_Mouse1.18005300
85* TBX3_20139965_ChIP-Seq_ESCs_Mouse1.17904280
86NFE2_27457419_Chip-Seq_LIVER_Mouse1.17466545
87CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17371638
88NR3C1_23031785_ChIP-Seq_PC12_Mouse1.16933531
89ERG_21242973_ChIP-ChIP_JURKAT_Human1.16066128
90* SOX9_26525672_Chip-Seq_HEART_Mouse1.15592330
91POU3F2_20337985_ChIP-ChIP_501MEL_Human1.15316834
92OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.14986921
93* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.14888118
94ARNT_22903824_ChIP-Seq_MCF-7_Human1.14875018
95TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.14493201
96PADI4_21655091_ChIP-ChIP_MCF-7_Human1.13947588
97* STAT3_23295773_ChIP-Seq_U87_Human1.13250349
98WT1_25993318_ChIP-Seq_PODOCYTE_Human1.12547848
99FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.12137681
100P53_22387025_ChIP-Seq_ESCs_Mouse1.12128891
101PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.11460037
102* AR_19668381_ChIP-Seq_PC3_Human1.11395505
103MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.10505122
104E2F1_18555785_Chip-Seq_ESCs_Mouse1.09611242
105TCF4_22108803_ChIP-Seq_LS180_Human1.09611082
106CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.08223269
107FUS_26573619_Chip-Seq_HEK293_Human1.08219365
108AHR_22903824_ChIP-Seq_MCF-7_Human1.07599201
109HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.07529057
110* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.07412196
111TP63_19390658_ChIP-ChIP_HaCaT_Human1.07307525
112RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.06679599
113* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.06354397
114SUZ12_18555785_Chip-Seq_ESCs_Mouse1.06285204
115NANOG_16153702_ChIP-ChIP_HESCs_Human1.05904858
116RING1B_27294783_Chip-Seq_NPCs_Mouse1.04641887
117SOX2_16153702_ChIP-ChIP_HESCs_Human1.04475790
118CMYC_18555785_Chip-Seq_ESCs_Mouse1.04463295
119NR3C1_21868756_ChIP-Seq_MCF10A_Human1.02834871
120TP53_16413492_ChIP-PET_HCT116_Human1.02562014
121IGF1R_20145208_ChIP-Seq_DFB_Human1.02460627
122KLF5_20875108_ChIP-Seq_MESCs_Mouse1.02230026
123* LXR_22158963_ChIP-Seq_LIVER_Mouse1.02174444
124* FLI1_21867929_ChIP-Seq_TH2_Mouse1.01866539
125RXR_22158963_ChIP-Seq_LIVER_Mouse1.01780289
126BMI1_23680149_ChIP-Seq_NPCS_Mouse1.01499239
127RNF2_27304074_Chip-Seq_NSC_Mouse1.01254106
128TCF4_18268006_ChIP-ChIP_LS174T_Human1.01184756
129SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.01067883
130RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.00874046
131P300_18555785_Chip-Seq_ESCs_Mouse0.98719882
132TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98557336
133POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.98557336
134TP53_18474530_ChIP-ChIP_U2OS_Human0.98010074
135RUNX2_22187159_ChIP-Seq_PCA_Human0.97929529
136ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.97432189
137SMAD4_21741376_ChIP-Seq_HESCs_Human0.96358906
138* TCF4_23295773_ChIP-Seq_U87_Human0.96122523
139KDM2B_26808549_Chip-Seq_K562_Human0.95568945
140BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.95524344
141GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94865107
142VDR_22108803_ChIP-Seq_LS180_Human0.94422919
143RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.94289387
144ER_23166858_ChIP-Seq_MCF-7_Human0.94046241
145* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.93951534
146* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.93820389
147* SMAD4_21741376_ChIP-Seq_EPCs_Human0.93776805
148IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.93492130
149CBP_20019798_ChIP-Seq_JUKART_Human0.93492130
150P53_22127205_ChIP-Seq_FIBROBLAST_Human0.93398376
151PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.92639179
152TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91794070
153TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.91494104

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.42176293
2MP0003880_abnormal_central_pattern4.70840746
3MP0003635_abnormal_synaptic_transmissio3.81278792
4MP0004270_analgesia3.51740901
5MP0002063_abnormal_learning/memory/cond3.15209828
6MP0000566_synostosis3.13550049
7MP0009745_abnormal_behavioral_response3.00020581
8MP0002064_seizures2.83123485
9MP0006292_abnormal_olfactory_placode2.69018017
10MP0009046_muscle_twitch2.68996375
11MP0003890_abnormal_embryonic-extraembry2.68797719
12MP0005423_abnormal_somatic_nervous2.60859784
13MP0002572_abnormal_emotion/affect_behav2.51591063
14MP0002139_abnormal_hepatobiliary_system2.43589941
15MP0001968_abnormal_touch/_nociception2.43455970
16MP0005360_urolithiasis2.35524951
17MP0000778_abnormal_nervous_system2.22416323
18MP0001440_abnormal_grooming_behavior2.22292492
19MP0001486_abnormal_startle_reflex2.19717301
20MP0003329_amyloid_beta_deposits2.10965981
21MP0008057_abnormal_DNA_replication2.10275593
22MP0008877_abnormal_DNA_methylation2.06340808
23MP0002272_abnormal_nervous_system2.04205386
24MP0003937_abnormal_limbs/digits/tail_de2.02555597
25MP0006276_abnormal_autonomic_nervous2.00274619
26MP0002734_abnormal_mechanical_nocicepti1.96664562
27MP0005085_abnormal_gallbladder_physiolo1.96146170
28MP0003787_abnormal_imprinting1.95115148
29MP0001293_anophthalmia1.92312512
30MP0002837_dystrophic_cardiac_calcinosis1.88015531
31MP0003121_genomic_imprinting1.86842341
32MP0002067_abnormal_sensory_capabilities1.84473931
33MP0002184_abnormal_innervation1.81162523
34MP0009780_abnormal_chondrocyte_physiolo1.80601221
35MP0001188_hyperpigmentation1.80085634
36MP0005248_abnormal_Harderian_gland1.78675636
37MP0002733_abnormal_thermal_nociception1.69530539
38MP0004885_abnormal_endolymph1.64607307
39MP0005386_behavior/neurological_phenoty1.63210914
40MP0004924_abnormal_behavior1.63210914
41MP0008875_abnormal_xenobiotic_pharmacok1.62018140
42MP0003941_abnormal_skin_development1.61850775
43MP0002736_abnormal_nociception_after1.61711862
44MP0002938_white_spotting1.60450034
45MP0002751_abnormal_autonomic_nervous1.59631493
46MP0002909_abnormal_adrenal_gland1.59397339
47MP0001501_abnormal_sleep_pattern1.57346180
48MP0002735_abnormal_chemical_nociception1.55692041
49MP0005365_abnormal_bile_salt1.52766185
50MP0004811_abnormal_neuron_physiology1.52513936
51MP0003755_abnormal_palate_morphology1.52102624
52MP0001286_abnormal_eye_development1.52050621
53MP0002822_catalepsy1.51298607
54MP0003567_abnormal_fetal_cardiomyocyte1.50248221
55MP0002557_abnormal_social/conspecific_i1.49610628
56MP0005187_abnormal_penis_morphology1.49553466
57MP0000383_abnormal_hair_follicle1.48934182
58MP0002233_abnormal_nose_morphology1.48565741
59MP0001970_abnormal_pain_threshold1.43309883
60MP0005410_abnormal_fertilization1.43023052
61MP0008569_lethality_at_weaning1.42712946
62MP0010678_abnormal_skin_adnexa1.42679831
63MP0000955_abnormal_spinal_cord1.41761207
64MP0000569_abnormal_digit_pigmentation1.39859218
65MP0000647_abnormal_sebaceous_gland1.38064789
66MP0002102_abnormal_ear_morphology1.35366872
67MP0010094_abnormal_chromosome_stability1.35085540
68MP0002066_abnormal_motor_capabilities/c1.34370096
69MP0003693_abnormal_embryo_hatching1.31338515
70MP0008961_abnormal_basal_metabolism1.31271304
71MP0001299_abnormal_eye_distance/1.31016863
72MP0000427_abnormal_hair_cycle1.30560044
73MP0008789_abnormal_olfactory_epithelium1.29240212
74MP0002882_abnormal_neuron_morphology1.28469379
75MP0003252_abnormal_bile_duct1.27474557
76MP0005499_abnormal_olfactory_system1.27324186
77MP0005394_taste/olfaction_phenotype1.27324186
78MP0008058_abnormal_DNA_repair1.26072739
79MP0005551_abnormal_eye_electrophysiolog1.25701103
80MP0004957_abnormal_blastocyst_morpholog1.25466561
81MP0002697_abnormal_eye_size1.25134183
82MP0003935_abnormal_craniofacial_develop1.24473677
83MP0003119_abnormal_digestive_system1.23102009
84MP0004133_heterotaxia1.22335056
85MP0004858_abnormal_nervous_system1.19204685
86MP0000428_abnormal_craniofacial_morphol1.18947012
87MP0002152_abnormal_brain_morphology1.18816113
88MP0002234_abnormal_pharynx_morphology1.18613156
89MP0009703_decreased_birth_body1.18473190
90MP0001984_abnormal_olfaction1.18404615
91MP0003718_maternal_effect1.18194906
92MP0000604_amyloidosis1.16966173
93MP0010329_abnormal_lipoprotein_level1.16798685
94MP0003385_abnormal_body_wall1.15396444
95MP0009697_abnormal_copulation1.15056170
96MP0009672_abnormal_birth_weight1.14210237
97MP0003122_maternal_imprinting1.12476304
98MP0010352_gastrointestinal_tract_polyps1.11923272
99MP0002084_abnormal_developmental_patter1.10933998
100MP0005253_abnormal_eye_physiology1.10755838
101MP0003633_abnormal_nervous_system1.10410323
102MP0008932_abnormal_embryonic_tissue1.09579816
103MP0010234_abnormal_vibrissa_follicle1.08285881
104MP0003123_paternal_imprinting1.07564369
105MP0004197_abnormal_fetal_growth/weight/1.06936856
106MP0005623_abnormal_meninges_morphology1.04672482
107MP0003077_abnormal_cell_cycle1.01176748
108MP0002085_abnormal_embryonic_tissue1.01007037
109MP0005535_abnormal_body_temperature1.00431386
110MP0001905_abnormal_dopamine_level0.99061971
111MP0000049_abnormal_middle_ear0.98932956
112MP0001529_abnormal_vocalization0.98723593
113MP0004742_abnormal_vestibular_system0.97669460
114MP0003631_nervous_system_phenotype0.96786828
115MP0003879_abnormal_hair_cell0.96605079
116MP0002177_abnormal_outer_ear0.95718591
117MP0000432_abnormal_head_morphology0.95499061
118MP0003938_abnormal_ear_development0.94641589
119MP0005391_vision/eye_phenotype0.94591714
120MP0002069_abnormal_eating/drinking_beha0.93959604
121MP0005367_renal/urinary_system_phenotyp0.93868756
122MP0000516_abnormal_urinary_system0.93868756
123MP0002081_perinatal_lethality0.93418802
124MP0003942_abnormal_urinary_system0.90958082
125MP0003868_abnormal_feces_composition0.89380974
126MP0002090_abnormal_vision0.89154782
127MP0005409_darkened_coat_color0.88314551
128MP0000751_myopathy0.87088201
129MP0010030_abnormal_orbit_morphology0.86643364
130MP0003111_abnormal_nucleus_morphology0.85715099
131MP0009250_abnormal_appendicular_skeleto0.85615719
132MP0003115_abnormal_respiratory_system0.85614616
133MP0001697_abnormal_embryo_size0.85040669
134MP0002229_neurodegeneration0.84899198
135MP0004215_abnormal_myocardial_fiber0.84763181
136MP0000534_abnormal_ureter_morphology0.84591118
137MP0000537_abnormal_urethra_morphology0.83810637
138MP0008874_decreased_physiological_sensi0.83771364
139MP0001346_abnormal_lacrimal_gland0.83100732
140MP0001502_abnormal_circadian_rhythm0.81516707
141MP0004142_abnormal_muscle_tone0.80983675
142MP0003283_abnormal_digestive_organ0.80917653
143MP0000579_abnormal_nail_morphology0.80601672
144MP0004130_abnormal_muscle_cell0.78869468
145MP0003632_abnormal_nervous_system0.78583649
146MP0008872_abnormal_physiological_respon0.78376568
147MP0005332_abnormal_amino_acid0.77043124
148MP0000920_abnormal_myelination0.75527767
149MP0001177_atelectasis0.75268123
150MP0006072_abnormal_retinal_apoptosis0.75134869
151MP0004085_abnormal_heartbeat0.74882256
152MP0003634_abnormal_glial_cell0.73175307
153MP0010386_abnormal_urinary_bladder0.72148393
154MP0004145_abnormal_muscle_electrophysio0.70518860
155MP0005645_abnormal_hypothalamus_physiol0.70504869
156MP0003861_abnormal_nervous_system0.70280026
157MP0005083_abnormal_biliary_tract0.68793284
158MP0003690_abnormal_glial_cell0.66695357
159MP0002138_abnormal_hepatobiliary_system0.65104649
160MP0000747_muscle_weakness0.64513589
161MP0002118_abnormal_lipid_homeostasis0.62305717
162MP0000013_abnormal_adipose_tissue0.61744990
163MP0005646_abnormal_pituitary_gland0.61157132
164MP0002752_abnormal_somatic_nervous0.59993537
165MP0010770_preweaning_lethality0.58433824
166MP0002082_postnatal_lethality0.58433824
167MP0003698_abnormal_male_reproductive0.57790176
168MP0010769_abnormal_survival0.56837339
169MP0000631_abnormal_neuroendocrine_gland0.56681330
170MP0002282_abnormal_trachea_morphology0.52917808

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.37888237
2Volvulus (HP:0002580)4.38947742
3Focal seizures (HP:0007359)4.37476140
4Visual hallucinations (HP:0002367)4.18877757
5Cerebral inclusion bodies (HP:0100314)3.73458299
6Hyperventilation (HP:0002883)3.63589214
7Myokymia (HP:0002411)3.58193905
8Intestinal atresia (HP:0011100)3.42554870
9Epileptic encephalopathy (HP:0200134)3.36105595
10Neurofibrillary tangles (HP:0002185)3.32958031
11Supranuclear gaze palsy (HP:0000605)3.19627929
12Abnormality of the labia minora (HP:0012880)3.18397516
13Progressive cerebellar ataxia (HP:0002073)3.17519540
14Generalized tonic-clonic seizures (HP:0002069)3.17445606
15Absence seizures (HP:0002121)3.14319872
16Deep venous thrombosis (HP:0002625)3.08811646
17Action tremor (HP:0002345)3.08181733
18Termporal pattern (HP:0011008)3.05550626
19Insidious onset (HP:0003587)3.05550626
20Broad-based gait (HP:0002136)2.98701828
21Dysdiadochokinesis (HP:0002075)2.97775287
22Abnormality of the corticospinal tract (HP:0002492)2.96853438
23Impaired vibration sensation in the lower limbs (HP:0002166)2.96050321
24Impaired social interactions (HP:0000735)2.94511817
25Abnormal social behavior (HP:0012433)2.94511817
26Drooling (HP:0002307)2.94087189
27Excessive salivation (HP:0003781)2.94087189
28Atonic seizures (HP:0010819)2.92654568
29Amyotrophic lateral sclerosis (HP:0007354)2.88595624
30Poor eye contact (HP:0000817)2.88537417
31Septo-optic dysplasia (HP:0100842)2.74399707
32Dialeptic seizures (HP:0011146)2.73855047
33Colon cancer (HP:0003003)2.72918714
34Abnormality of the lower motor neuron (HP:0002366)2.70504745
35Urinary bladder sphincter dysfunction (HP:0002839)2.68721170
36Genetic anticipation (HP:0003743)2.67780330
37Papillary thyroid carcinoma (HP:0002895)2.66705539
38Intention tremor (HP:0002080)2.66535403
39Febrile seizures (HP:0002373)2.64092015
40Depression (HP:0000716)2.63334680
41Amblyopia (HP:0000646)2.62283867
42Status epilepticus (HP:0002133)2.59260743
43Truncal ataxia (HP:0002078)2.58842647
44Mutism (HP:0002300)2.56496664
45Agitation (HP:0000713)2.55238851
46Gaze-evoked nystagmus (HP:0000640)2.40537655
47Anxiety (HP:0000739)2.39495083
48Scanning speech (HP:0002168)2.39347446
49Absent/shortened dynein arms (HP:0200106)2.36777103
50Dynein arm defect of respiratory motile cilia (HP:0012255)2.36777103
51Abnormal lung lobation (HP:0002101)2.36617369
52Dysmetria (HP:0001310)2.36485135
53Postural instability (HP:0002172)2.33727776
54Urinary urgency (HP:0000012)2.33317186
55Inappropriate behavior (HP:0000719)2.29474880
56Complement deficiency (HP:0004431)2.26756898
57Generalized myoclonic seizures (HP:0002123)2.26099786
58Epileptiform EEG discharges (HP:0011182)2.25850154
59EEG with generalized epileptiform discharges (HP:0011198)2.25095672
60Impaired vibratory sensation (HP:0002495)2.23439580
61Aqueductal stenosis (HP:0002410)2.22879471
62Papilledema (HP:0001085)2.22860476
63Optic nerve hypoplasia (HP:0000609)2.22833978
64Hemiparesis (HP:0001269)2.21471864
65Morphological abnormality of the pyramidal tract (HP:0002062)2.21235344
66Dysmetric saccades (HP:0000641)2.20399189
67Absent speech (HP:0001344)2.19727947
68Abnormality of binocular vision (HP:0011514)2.19586576
69Diplopia (HP:0000651)2.19586576
70Thyroid carcinoma (HP:0002890)2.17267798
71Hypsarrhythmia (HP:0002521)2.17154193
72Gastrointestinal atresia (HP:0002589)2.15989400
73Pheochromocytoma (HP:0002666)2.14553489
74Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.13467720
75Degeneration of the lateral corticospinal tracts (HP:0002314)2.13467720
76Spastic gait (HP:0002064)2.11970437
77Abnormality of aromatic amino acid family metabolism (HP:0004338)2.05610135
78Macroorchidism (HP:0000053)2.04084582
79Blue irides (HP:0000635)2.04022907
80Fair hair (HP:0002286)2.02922065
81Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.02307389
82Abnormal eating behavior (HP:0100738)2.01766713
83Pancreatic cysts (HP:0001737)2.00653946
84Abnormality of chromosome stability (HP:0003220)2.00339047
85Hypobetalipoproteinemia (HP:0003563)2.00113627
86Abnormality of ocular smooth pursuit (HP:0000617)1.99301007
87Nephroblastoma (Wilms tumor) (HP:0002667)1.98492876
88Torticollis (HP:0000473)1.95960041
89Impaired smooth pursuit (HP:0007772)1.95743059
90Pancreatic fibrosis (HP:0100732)1.95006952
91Protruding tongue (HP:0010808)1.94172372
92Cerebral hemorrhage (HP:0001342)1.93720277
93Embryonal renal neoplasm (HP:0011794)1.93481550
94Limb dystonia (HP:0002451)1.93220693
95Abnormality of midbrain morphology (HP:0002418)1.93175377
96Molar tooth sign on MRI (HP:0002419)1.93175377
97Cortical dysplasia (HP:0002539)1.92609221
98Hemiplegia (HP:0002301)1.92536448
99Bifid tongue (HP:0010297)1.90857806
100Nephronophthisis (HP:0000090)1.90573041
101Oligodactyly (hands) (HP:0001180)1.89756027
102Rhabdomyosarcoma (HP:0002859)1.89175391
103Prolonged partial thromboplastin time (HP:0003645)1.88928192
104Abnormality of the septum pellucidum (HP:0007375)1.88330025
105Genital tract atresia (HP:0001827)1.88249189
106True hermaphroditism (HP:0010459)1.88021115
107Scrotal hypoplasia (HP:0000046)1.87481528
108Renal hypoplasia (HP:0000089)1.87036716
109Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.86798097
110Abnormality of the Achilles tendon (HP:0005109)1.86274121
111Labial hypoplasia (HP:0000066)1.85746110
112Buphthalmos (HP:0000557)1.85391146
113Abnormal hair whorl (HP:0010721)1.84548553
114Absent septum pellucidum (HP:0001331)1.84400209
115Medial flaring of the eyebrow (HP:0010747)1.84191422
116Lower limb muscle weakness (HP:0007340)1.83999551
117Vaginal atresia (HP:0000148)1.83525700
118Neuronal loss in central nervous system (HP:0002529)1.83509948
119Stereotypic behavior (HP:0000733)1.83141659
120Exotropia (HP:0000577)1.82385844
121Polyphagia (HP:0002591)1.81347683
122Clumsiness (HP:0002312)1.81270873
123Neoplasm of the adrenal cortex (HP:0100641)1.80334138
124Bradykinesia (HP:0002067)1.80045850
125Aplasia/Hypoplasia of the uvula (HP:0010293)1.79173455
126Hyperthyroidism (HP:0000836)1.77628491
127Ankle clonus (HP:0011448)1.77451602
128Meckel diverticulum (HP:0002245)1.76699349
129Chorioretinal coloboma (HP:0000567)1.76195795
130Hepatoblastoma (HP:0002884)1.75752571
131Absent eyebrow (HP:0002223)1.75586388
132Glioma (HP:0009733)1.74806689
133Intrahepatic cholestasis (HP:0001406)1.74728239
134Abnormal respiratory motile cilium physiology (HP:0012261)1.74437681
135Abnormality of the ischium (HP:0003174)1.74282644
136Apathy (HP:0000741)1.73982462
137Abnormality of the astrocytes (HP:0100707)1.73670775
138Astrocytoma (HP:0009592)1.73670775
139Hypoplastic labia majora (HP:0000059)1.73387191
140Hypoplastic female external genitalia (HP:0012815)1.73337574
141Restlessness (HP:0000711)1.73245684
142Neuroendocrine neoplasm (HP:0100634)1.73107422
143Focal dystonia (HP:0004373)1.73091195
144Hyperlipoproteinemia (HP:0010980)1.72776003
145Abnormality of the ileum (HP:0001549)1.72576759
146Global brain atrophy (HP:0002283)1.72066810
147Megalencephaly (HP:0001355)1.71429518
148Gait imbalance (HP:0002141)1.70854235
149Esophageal atresia (HP:0002032)1.70431651
150Medulloblastoma (HP:0002885)1.70040414
151Increased nuchal translucency (HP:0010880)1.70006565
152Micropenis (HP:0000054)1.69532141
153Shawl scrotum (HP:0000049)1.68696091
154Hypoplastic ischia (HP:0003175)1.68504771
155Abnormality of the antihelix (HP:0009738)1.67859837
156Lissencephaly (HP:0001339)1.67432552
157Postaxial hand polydactyly (HP:0001162)1.67124672
158Long clavicles (HP:0000890)1.66643552
159Aplasia/Hypoplasia of the sternum (HP:0006714)1.65173989
160Biliary tract neoplasm (HP:0100574)1.64800050
161Hypoplastic pelvis (HP:0008839)1.64585660
162Abnormality of the renal medulla (HP:0100957)1.64037699
163Dandy-Walker malformation (HP:0001305)1.63613857
164Aplasia/Hypoplasia of the tongue (HP:0010295)1.63518377
165Growth hormone deficiency (HP:0000824)1.63207537
166Abnormal biliary tract morphology (HP:0012440)1.60725558
167Abnormality of the metopic suture (HP:0005556)1.60074281
168Sloping forehead (HP:0000340)1.59411263
169Abnormality of the duodenum (HP:0002246)1.58987041
170Acute lymphatic leukemia (HP:0006721)1.58483239
171Small hand (HP:0200055)1.58161362
172Anophthalmia (HP:0000528)1.57754433
173Chromsome breakage (HP:0040012)1.56852810
174Preaxial hand polydactyly (HP:0001177)1.56726943
175Congenital primary aphakia (HP:0007707)1.55361525
176Neoplasm of the oral cavity (HP:0100649)1.54526695
177Curly hair (HP:0002212)1.53521962
178Supernumerary spleens (HP:0009799)1.50839081
179Gastroesophageal reflux (HP:0002020)1.50360754
180Narrow forehead (HP:0000341)1.47630452
181Congenital malformation of the right heart (HP:0011723)1.46902544
182Double outlet right ventricle (HP:0001719)1.46902544
183Breast carcinoma (HP:0003002)1.46882174
184Abnormality of the labia majora (HP:0012881)1.46712818
185Sclerocornea (HP:0000647)1.45960107
186Oligodactyly (HP:0012165)1.45648524
187Nephrogenic diabetes insipidus (HP:0009806)1.44425686
188Hemivertebrae (HP:0002937)1.44318055
189Cupped ear (HP:0000378)1.42735988
190Thin upper lip vermilion (HP:0000219)1.41200841
191Hypoplastic iliac wings (HP:0002866)1.41011262
192Neoplasm of the thyroid gland (HP:0100031)1.40605221

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MKNK24.79354059
2MARK13.96809179
3MAP3K93.60004801
4NTRK33.38816893
5MKNK13.20853320
6MAP3K43.19679941
7EPHA42.89845254
8PNCK2.88427933
9MINK12.47252450
10MAP2K42.43611265
11SIK22.28388310
12TRIM282.23129490
13NEK12.16618003
14TYRO32.11298132
15NTRK22.09469674
16WEE11.99129511
17NTRK11.95043287
18TAF11.94365256
19KSR21.90593510
20SRPK11.89819413
21PAK61.89099628
22DAPK21.86362660
23MAP2K71.82353870
24KSR11.81946577
25BCR1.81164421
26EIF2AK31.71153513
27NUAK11.69857645
28PLK31.68203410
29BUB11.67181909
30LATS11.62813206
31LATS21.55599578
32PDK41.52300506
33PDK31.52300506
34BRSK21.51031700
35BMPR1B1.49763947
36MAP3K121.48345237
37RIPK41.47818217
38PRKD31.46559790
39STK38L1.45173072
40FES1.45110690
41TTK1.43999275
42CAMKK11.37625720
43STK31.35844050
44PLK41.33508350
45TSSK61.30717658
46CDC71.30014181
47MAP3K21.29770305
48MAP4K21.28607168
49PLK21.28499277
50CDK51.27602508
51STK381.27439224
52CAMK1G1.21585948
53MST41.21006817
54RET1.20395847
55ERBB31.20127679
56PAK31.19805136
57FGFR21.19120101
58NLK1.16243138
59STK111.15421164
60MAPK131.09720717
61EIF2AK11.07611725
62PRKCG1.06081800
63NEK21.05745382
64ICK1.05094754
65GRK51.02630545
66PBK0.94002512
67UHMK10.93841663
68PLK10.93662214
69BMPR20.93407730
70PTK2B0.92652437
71DMPK0.91386436
72FER0.90800605
73DYRK20.87993006
74TAOK10.87851525
75EIF2AK20.87592103
76MAP3K130.86081085
77CAMK2A0.85227683
78ACVR1B0.84856558
79CSNK1G20.84653934
80PRKCH0.84179305
81TRIB30.83454542
82PHKG20.82893402
83PHKG10.82893402
84FGFR10.81620452
85STK240.79980361
86WNK40.79163148
87PDK20.79058652
88BRD40.78743240
89CDK140.74847328
90CSNK1G10.74835820
91WNK10.74017725
92RPS6KA40.73746830
93DYRK30.73229391
94DAPK10.73125666
95CASK0.72241362
96MAP3K70.69514814
97DYRK1A0.69235974
98FGR0.68383457
99PDGFRA0.66980434
100CAMK2B0.64999329
101CHEK20.64506139
102PDK10.64181170
103GRK60.64087131
104CDK150.63795979
105MAP3K60.63221246
106CDK180.62614323
107SGK10.62306555
108PRKCZ0.61334490
109WNK30.61285895
110EPHB20.61103184
111ZAK0.59577409
112SGK2230.59165775
113SGK4940.59165775
114PASK0.59085919
115IRAK20.58779482
116CSNK1E0.58656438
117SGK30.57789463
118VRK10.54797868
119MAPK120.54488509
120TNIK0.53240568
121SGK20.52965629
122STK160.52771483
123CDK11A0.52206081
124MAP3K100.51678761
125OXSR10.51296596
126GRK10.51090522
127YES10.51017295
128ATM0.50966404
129RAF10.50616227
130CDK190.49132569
131ERBB40.48156988
132TGFBR10.48147243
133PDPK10.47719753
134FYN0.47643350
135MARK20.47305154
136CSNK1A1L0.47065958
137RPS6KA30.46250260
138CDK30.45586206
139ALK0.45186137
140STK390.44291476
141PKN10.43106463
142CAMK10.42810715
143MAPK100.42684531
144PKN20.42185205
145CSNK1G30.41879139
146MAP2K10.41350997
147RIPK10.40836992
148PINK10.40466504
149SIK30.39878149
150PDGFRB0.37444529
151PRKACG0.37171852
152HIPK20.36877596
153FRK0.36846243
154PRKCE0.36001909
155CSNK1D0.34172564
156AKT30.33736339
157CDK10.32696967
158AURKB0.32087212
159CHEK10.30903799
160PRKG10.30767393
161BRSK10.30579820

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030603.15339019
2Nitrogen metabolism_Homo sapiens_hsa009102.84102627
3Nicotine addiction_Homo sapiens_hsa050332.77147729
4Non-homologous end-joining_Homo sapiens_hsa034502.63281366
5Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.38809164
6Long-term potentiation_Homo sapiens_hsa047202.25931665
7Basal transcription factors_Homo sapiens_hsa030222.20210938
8GABAergic synapse_Homo sapiens_hsa047272.17764315
9Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.11775933
10Synaptic vesicle cycle_Homo sapiens_hsa047212.08120347
11Glutamatergic synapse_Homo sapiens_hsa047242.06389071
12Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.04768717
13Amphetamine addiction_Homo sapiens_hsa050312.04010374
14Steroid biosynthesis_Homo sapiens_hsa001001.96647750
15Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.92831241
16Circadian entrainment_Homo sapiens_hsa047131.91277364
17Selenocompound metabolism_Homo sapiens_hsa004501.88993159
18* Dopaminergic synapse_Homo sapiens_hsa047281.84372265
19Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.82286377
20Primary bile acid biosynthesis_Homo sapiens_hsa001201.75869473
21Renin secretion_Homo sapiens_hsa049241.74530063
22RNA transport_Homo sapiens_hsa030131.73360767
23Morphine addiction_Homo sapiens_hsa050321.71860814
24Cell cycle_Homo sapiens_hsa041101.67901699
25Salivary secretion_Homo sapiens_hsa049701.63148509
26Arginine biosynthesis_Homo sapiens_hsa002201.60931988
27Hippo signaling pathway_Homo sapiens_hsa043901.57515569
28Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.56205041
29Fanconi anemia pathway_Homo sapiens_hsa034601.55024092
30RNA degradation_Homo sapiens_hsa030181.52871051
31Olfactory transduction_Homo sapiens_hsa047401.52848758
32Homologous recombination_Homo sapiens_hsa034401.52673014
33Hedgehog signaling pathway_Homo sapiens_hsa043401.52205457
34Gastric acid secretion_Homo sapiens_hsa049711.51434367
35Long-term depression_Homo sapiens_hsa047301.49353479
36Basal cell carcinoma_Homo sapiens_hsa052171.49213577
37Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.45959164
38RNA polymerase_Homo sapiens_hsa030201.45626203
39Cholinergic synapse_Homo sapiens_hsa047251.45552302
40Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.45118851
41Cocaine addiction_Homo sapiens_hsa050301.40105545
42Aldosterone synthesis and secretion_Homo sapiens_hsa049251.40083432
43Insulin secretion_Homo sapiens_hsa049111.37802537
44Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.33904769
45Oxytocin signaling pathway_Homo sapiens_hsa049211.33755919
46Maturity onset diabetes of the young_Homo sapiens_hsa049501.33127473
47Butanoate metabolism_Homo sapiens_hsa006501.31086092
48Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.30459849
49Serotonergic synapse_Homo sapiens_hsa047261.30410102
50Taste transduction_Homo sapiens_hsa047421.30000045
51Bile secretion_Homo sapiens_hsa049761.29478600
52* Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.27695719
53Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.26445581
54* mRNA surveillance pathway_Homo sapiens_hsa030151.21595512
55Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.20499919
56Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.19379776
57Mismatch repair_Homo sapiens_hsa034301.19003451
58GnRH signaling pathway_Homo sapiens_hsa049121.18632912
59Axon guidance_Homo sapiens_hsa043601.17278890
60Estrogen signaling pathway_Homo sapiens_hsa049151.15421865
61Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.14025639
62Gap junction_Homo sapiens_hsa045401.12510065
63TGF-beta signaling pathway_Homo sapiens_hsa043501.12148668
64Phototransduction_Homo sapiens_hsa047441.09918271
65Adherens junction_Homo sapiens_hsa045201.08138453
66Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.08096046
67One carbon pool by folate_Homo sapiens_hsa006701.07177917
68Calcium signaling pathway_Homo sapiens_hsa040201.05712386
69Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.04537930
70Circadian rhythm_Homo sapiens_hsa047101.03163811
71Dorso-ventral axis formation_Homo sapiens_hsa043201.02695512
72Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.01685390
73p53 signaling pathway_Homo sapiens_hsa041151.01542270
74Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.99472056
75Spliceosome_Homo sapiens_hsa030400.97973221
76Nucleotide excision repair_Homo sapiens_hsa034200.97458131
77Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.95401730
78Tight junction_Homo sapiens_hsa045300.94971919
79Glioma_Homo sapiens_hsa052140.94897149
80Type II diabetes mellitus_Homo sapiens_hsa049300.94819644
81Glucagon signaling pathway_Homo sapiens_hsa049220.92361346
82Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.91878238
83Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.90457821
84Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.90387866
85Melanogenesis_Homo sapiens_hsa049160.90383018
86Cysteine and methionine metabolism_Homo sapiens_hsa002700.89717089
87Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.89469577
88cAMP signaling pathway_Homo sapiens_hsa040240.88051029
89Complement and coagulation cascades_Homo sapiens_hsa046100.87044176
90Proteasome_Homo sapiens_hsa030500.85748103
91ErbB signaling pathway_Homo sapiens_hsa040120.85661273
92cGMP-PKG signaling pathway_Homo sapiens_hsa040220.84491658
93MicroRNAs in cancer_Homo sapiens_hsa052060.82971717
94Colorectal cancer_Homo sapiens_hsa052100.82407151
95Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.81329462
96Thyroid hormone synthesis_Homo sapiens_hsa049180.81166087
97Collecting duct acid secretion_Homo sapiens_hsa049660.78652472
98Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.77749345
99Vitamin B6 metabolism_Homo sapiens_hsa007500.75501139
100Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.72487061
101Tryptophan metabolism_Homo sapiens_hsa003800.72266933
102Folate biosynthesis_Homo sapiens_hsa007900.71982455
103Phosphatidylinositol signaling system_Homo sapiens_hsa040700.68349476
104Propanoate metabolism_Homo sapiens_hsa006400.67369078
105Melanoma_Homo sapiens_hsa052180.67015315
106Choline metabolism in cancer_Homo sapiens_hsa052310.62986424
107Vascular smooth muscle contraction_Homo sapiens_hsa042700.62394192
108Phospholipase D signaling pathway_Homo sapiens_hsa040720.59028144
109Prion diseases_Homo sapiens_hsa050200.58140781
110Purine metabolism_Homo sapiens_hsa002300.57677695
111Carbohydrate digestion and absorption_Homo sapiens_hsa049730.57382442
112VEGF signaling pathway_Homo sapiens_hsa043700.56074223
113Fatty acid elongation_Homo sapiens_hsa000620.55827878
114Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.55264250
115Prostate cancer_Homo sapiens_hsa052150.54116448
116Cardiac muscle contraction_Homo sapiens_hsa042600.53808203
117PPAR signaling pathway_Homo sapiens_hsa033200.53667671
118* Oocyte meiosis_Homo sapiens_hsa041140.52246063
119Thyroid cancer_Homo sapiens_hsa052160.51586380
120Phenylalanine metabolism_Homo sapiens_hsa003600.49975071
121Pancreatic secretion_Homo sapiens_hsa049720.49937288
122Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.48987280
123Lysine degradation_Homo sapiens_hsa003100.47743084
124Renal cell carcinoma_Homo sapiens_hsa052110.47421896
125MAPK signaling pathway_Homo sapiens_hsa040100.47403256
126Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.47054631
127Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.47011942
128Huntingtons disease_Homo sapiens_hsa050160.46502257
129Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.45848633
130Pyruvate metabolism_Homo sapiens_hsa006200.45713185
131Thyroid hormone signaling pathway_Homo sapiens_hsa049190.45329028
132mTOR signaling pathway_Homo sapiens_hsa041500.45282268
133Insulin signaling pathway_Homo sapiens_hsa049100.45201604
134Fatty acid metabolism_Homo sapiens_hsa012120.44936646
135Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.43805416
136Fatty acid degradation_Homo sapiens_hsa000710.43413516
137Endometrial cancer_Homo sapiens_hsa052130.40180979
138* AMPK signaling pathway_Homo sapiens_hsa041520.40158114
139Regulation of autophagy_Homo sapiens_hsa041400.39589123
140Wnt signaling pathway_Homo sapiens_hsa043100.38652548
141Ras signaling pathway_Homo sapiens_hsa040140.38584038
142Caffeine metabolism_Homo sapiens_hsa002320.37846594
143Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.37297339
144Non-small cell lung cancer_Homo sapiens_hsa052230.35920577
145Dilated cardiomyopathy_Homo sapiens_hsa054140.35037709
146Central carbon metabolism in cancer_Homo sapiens_hsa052300.34682269
147Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.34063196
148beta-Alanine metabolism_Homo sapiens_hsa004100.33716143
149Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.33414978
150Pathways in cancer_Homo sapiens_hsa052000.33244692
151Fatty acid biosynthesis_Homo sapiens_hsa000610.32877029
152Oxidative phosphorylation_Homo sapiens_hsa001900.32622297
153Vibrio cholerae infection_Homo sapiens_hsa051100.31053174
154Glycerolipid metabolism_Homo sapiens_hsa005610.30341672
155Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.30019891

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