PPP3CC

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Calcineurin is a calcium-dependent, calmodulin-stimulated protein phosphatase involved in the downstream regulation of dopaminergic signal transduction. Calcineurin is composed of a regulatory subunit and a catalytic subunit. The protein encoded by this gene represents one of the regulatory subunits that has been found for calcineurin. Three transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1fusion of sperm to egg plasma membrane (GO:0007342)8.08471730
2cilium or flagellum-dependent cell motility (GO:0001539)7.42058679
3sperm motility (GO:0030317)7.39887528
4acrosome assembly (GO:0001675)7.14464111
5multicellular organism reproduction (GO:0032504)6.77344733
6acrosome reaction (GO:0007340)6.40469230
7sperm-egg recognition (GO:0035036)6.34684899
8cell wall macromolecule catabolic process (GO:0016998)6.34316047
9cell wall macromolecule metabolic process (GO:0044036)6.34316047
10plasma membrane fusion (GO:0045026)6.23067367
11cell-cell recognition (GO:0009988)5.99819965
12negative regulation of inclusion body assembly (GO:0090084)5.85195054
13motile cilium assembly (GO:0044458)5.78041191
14reproduction (GO:0000003)5.65935842
15axonemal dynein complex assembly (GO:0070286)5.44437934
16binding of sperm to zona pellucida (GO:0007339)5.44150018
17piRNA metabolic process (GO:0034587)5.32657379
18spermatid development (GO:0007286)5.27967502
19epithelial cilium movement (GO:0003351)4.97541744
20male meiosis (GO:0007140)4.88114595
21negative regulation of cell killing (GO:0031342)4.82190344
22negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.82190344
23positive regulation of gamma-delta T cell activation (GO:0046645)4.75850904
24synaptonemal complex organization (GO:0070193)4.58948525
25single fertilization (GO:0007338)4.43710150
26positive thymic T cell selection (GO:0045059)4.39193950
27epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.38825456
28negative T cell selection (GO:0043383)4.36588650
29negative thymic T cell selection (GO:0045060)4.27606887
30activated T cell proliferation (GO:0050798)4.25029389
31synaptonemal complex assembly (GO:0007130)4.20665461
32response to interleukin-15 (GO:0070672)4.18365758
33cilium movement (GO:0003341)4.15861697
34antigen processing and presentation of endogenous antigen (GO:0019883)4.02917424
35antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.02092090
36antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.02092090
37regulation of cilium movement (GO:0003352)4.00532001
38cellular response to interleukin-15 (GO:0071350)3.98543597
39regulation of inclusion body assembly (GO:0090083)3.96783480
40positive T cell selection (GO:0043368)3.95879475
41negative regulation of interleukin-12 production (GO:0032695)3.94127954
42B cell receptor signaling pathway (GO:0050853)3.90408545
43regulation of gamma-delta T cell differentiation (GO:0045586)3.77976620
44sperm capacitation (GO:0048240)3.77873579
45thymic T cell selection (GO:0045061)3.77058369
46regulation of T-helper 1 cell differentiation (GO:0045625)3.73130017
47fertilization (GO:0009566)3.70344861
48T cell selection (GO:0045058)3.58879043
49regulation of isotype switching to IgG isotypes (GO:0048302)3.58541469
50spermatogenesis (GO:0007283)3.56908756
51negative regulation of T cell mediated immunity (GO:0002710)3.56884658
52male gamete generation (GO:0048232)3.55305568
53type I interferon signaling pathway (GO:0060337)3.53407722
54cellular response to type I interferon (GO:0071357)3.53407722
55calcium ion-dependent exocytosis (GO:0017156)3.53303399
56response to type I interferon (GO:0034340)3.49512482
57mature B cell differentiation (GO:0002335)3.44720328
58NIK/NF-kappaB signaling (GO:0038061)3.42365146
59immunoglobulin mediated immune response (GO:0016064)3.40059746
60germinal center formation (GO:0002467)3.39163272
61defense response to protozoan (GO:0042832)3.35215126
62regulation of alpha-beta T cell proliferation (GO:0046640)3.34949771
63regulation of B cell receptor signaling pathway (GO:0050855)3.34292603
64regulation of gamma-delta T cell activation (GO:0046643)3.29305036
65interferon-gamma production (GO:0032609)3.27923921
66leukocyte aggregation (GO:0070486)3.26113572
67gamete generation (GO:0007276)3.24360050
68seminiferous tubule development (GO:0072520)3.23995110
69response to protozoan (GO:0001562)3.23554253
70positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.23236510
71interferon-gamma-mediated signaling pathway (GO:0060333)3.22894568
72response to peptidoglycan (GO:0032494)3.22475341
73protein localization to cilium (GO:0061512)3.22443521
74retinal cone cell development (GO:0046549)3.21074615
75positive regulation of B cell differentiation (GO:0045579)3.20994523
76regulation of interleukin-2 biosynthetic process (GO:0045076)3.19890653
77lactate metabolic process (GO:0006089)3.19836206
78antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.18813860
79regulation of interleukin-12 biosynthetic process (GO:0045075)3.18508690
80positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)3.17395091
81positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.16418195
82tolerance induction (GO:0002507)3.16220444
83response to muramyl dipeptide (GO:0032495)3.15213155
84positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)3.14999895
85positive regulation of alpha-beta T cell proliferation (GO:0046641)3.13541378
86T cell migration (GO:0072678)3.13503888
87cellular process involved in reproduction in multicellular organism (GO:0022412)3.11624027
88positive regulation of interleukin-2 production (GO:0032743)3.08323090
89ventricular system development (GO:0021591)3.07087445
90negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.05022871
91mature B cell differentiation involved in immune response (GO:0002313)3.04126195
92cell recognition (GO:0008037)3.03969406
93macrophage activation involved in immune response (GO:0002281)3.02966244
94DNA methylation involved in gamete generation (GO:0043046)3.02150934
95lipid translocation (GO:0034204)3.01478945
96phospholipid translocation (GO:0045332)3.01478945
97germ cell development (GO:0007281)3.01407886
98regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)3.01169326
99sequestering of actin monomers (GO:0042989)3.00612250
100regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.99819414
101establishment of protein localization to Golgi (GO:0072600)2.99359924
102B cell proliferation (GO:0042100)2.99211583
103positive regulation of natural killer cell differentiation (GO:0032825)2.98998648
104T cell costimulation (GO:0031295)2.98415552
105regulation of rhodopsin mediated signaling pathway (GO:0022400)2.97777080
106positive regulation of granulocyte differentiation (GO:0030854)2.97275992
107regulation of necroptotic process (GO:0060544)2.96592967
108myeloid dendritic cell differentiation (GO:0043011)2.96069780
109male meiosis I (GO:0007141)2.93468319
110lipopolysaccharide-mediated signaling pathway (GO:0031663)2.93416019
111regulation of T cell mediated cytotoxicity (GO:0001914)2.91727438
112rhodopsin mediated signaling pathway (GO:0016056)2.90603733
113lymphocyte costimulation (GO:0031294)2.90508476
114regulation of germinal center formation (GO:0002634)2.90129791
115positive regulation of type 2 immune response (GO:0002830)2.90118051
116regulation of dendritic cell antigen processing and presentation (GO:0002604)2.88196399
117protein targeting to Golgi (GO:0000042)2.88174905
118positive regulation of histone deacetylation (GO:0031065)2.87732512
119negative regulation of lymphocyte mediated immunity (GO:0002707)2.86646969
120retrograde transport, vesicle recycling within Golgi (GO:0000301)2.85517163
121regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.84927696
122regulation of natural killer cell mediated immunity (GO:0002715)2.84927696
123antigen receptor-mediated signaling pathway (GO:0050851)2.84395829
124regulation of T-helper 2 cell differentiation (GO:0045628)2.84262493
125regulation of chronic inflammatory response (GO:0002676)2.83718471
126regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.82095170
127negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.81866734
128myeloid dendritic cell activation (GO:0001773)2.81802287
129regulation of interleukin-12 production (GO:0032655)2.81193761
130regulation of alpha-beta T cell activation (GO:0046634)2.80128914
131regulation of B cell differentiation (GO:0045577)2.78418822
132modulation by symbiont of host defense response (GO:0052031)2.78177925
133modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.78177925
134modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.78177925
135positive regulation by organism of defense response of other organism involved in symbiotic interact2.78177925
136modulation by symbiont of host immune response (GO:0052553)2.78177925
137positive regulation by symbiont of host defense response (GO:0052509)2.78177925
138neutrophil activation involved in immune response (GO:0002283)2.78058941
139Peyers patch development (GO:0048541)2.77986467
140mucosal-associated lymphoid tissue development (GO:0048537)2.77986467
141regulation of tolerance induction (GO:0002643)2.75937458
142positive regulation of natural killer cell mediated immunity (GO:0002717)2.75891415
143positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)2.75891415
144positive regulation of B cell proliferation (GO:0030890)2.75537022
145B cell homeostasis (GO:0001782)2.74490689
146adaptation of signaling pathway (GO:0023058)2.73752908
147cellular extravasation (GO:0045123)2.71892743
148lymphocyte migration (GO:0072676)2.71036751
149CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.70656950
150T-helper cell differentiation (GO:0042093)2.70656950
151regulation of T-helper cell differentiation (GO:0045622)2.69921545
152sarcoplasmic reticulum calcium ion transport (GO:0070296)2.69863767
153microtubule severing (GO:0051013)2.68914228
154negative regulation of T-helper cell differentiation (GO:0045623)2.68629539
155negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.68629539
156lymphocyte chemotaxis (GO:0048247)2.68398934
157negative regulation of cytokine production involved in immune response (GO:0002719)2.68041238
158T cell receptor signaling pathway (GO:0050852)2.67816481
159regulation of interferon-alpha production (GO:0032647)2.67519943
160negative regulation of leukocyte mediated immunity (GO:0002704)2.67375451
161positive regulation of humoral immune response (GO:0002922)2.67276032
162positive regulation of B cell activation (GO:0050871)2.67047461
163positive regulation of tolerance induction (GO:0002645)2.60657896
164regulation of T cell tolerance induction (GO:0002664)2.60405433
165meiotic nuclear division (GO:0007126)2.59395008
166spermatid nucleus differentiation (GO:0007289)2.58787222
167chromosome organization involved in meiosis (GO:0070192)2.54876639
168negative regulation of necroptotic process (GO:0060546)2.53429553
169organic cation transport (GO:0015695)2.52951844
170left/right pattern formation (GO:0060972)2.52313952
171multicellular organismal reproductive process (GO:0048609)2.51039828

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.31531014
2BP1_19119308_ChIP-ChIP_Hs578T_Human5.06087324
3MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse4.67905988
4EZH2_22144423_ChIP-Seq_EOC_Human4.50732241
5* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.15018551
6SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.08820821
7BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.08258541
8RUNX_20019798_ChIP-Seq_JUKART_Human2.66638797
9IRF8_22096565_ChIP-ChIP_GC-B_Human2.51437605
10TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.51100566
11MYB_21317192_ChIP-Seq_ERMYB_Mouse2.47020882
12FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.45700412
13SCL_19346495_ChIP-Seq_HPC-7_Human2.27221891
14STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.25620637
15RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.11585697
16EGR1_19374776_ChIP-ChIP_THP-1_Human2.07132122
17* MYB_26560356_Chip-Seq_TH2_Human2.06165385
18Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.04544493
19IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.92572962
20SPI1_23547873_ChIP-Seq_NB4_Human1.91261983
21* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.89231960
22LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.80185712
23MYB_26560356_Chip-Seq_TH1_Human1.79481152
24PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.78508627
25VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.78431467
26NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.77868283
27MYC_22102868_ChIP-Seq_BL_Human1.74893953
28IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.66196741
29STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.65320697
30MAF_26560356_Chip-Seq_TH1_Human1.59912478
31* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.59294482
32KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.58179262
33NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.56627216
34* GATA3_27048872_Chip-Seq_THYMUS_Human1.51437611
35WDR5_24793694_ChIP-Seq_LNCAP_Human1.51192407
36TCF7_22412390_ChIP-Seq_EML_Mouse1.48933214
37DROSHA_22980978_ChIP-Seq_HELA_Human1.48590509
38UTX_26944678_Chip-Seq_JUKART_Human1.45481050
39E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.43718788
40GATA2_21666600_ChIP-Seq_HMVEC_Human1.40659531
41SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.38678341
42FLI1_27457419_Chip-Seq_LIVER_Mouse1.35990786
43ELK4_26923725_Chip-Seq_MESODERM_Mouse1.34879268
44* EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.34767289
45TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.33767278
46IRF8_27001747_Chip-Seq_BMDM_Mouse1.33625047
47KDM2B_26808549_Chip-Seq_DND41_Human1.32457133
48SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.31610320
49ZNF274_21170338_ChIP-Seq_K562_Hela1.31211941
50FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.31176565
51GATA1_19941827_ChIP-Seq_MEL_Mouse1.30938245
52GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.30614991
53ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.28731120
54PU_27001747_Chip-Seq_BMDM_Mouse1.28509490
55SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.28303971
56FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.28149391
57ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.26910424
58RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.26315709
59GATA2_22383799_ChIP-Seq_G1ME_Mouse1.25812915
60IRF8_21731497_ChIP-ChIP_J774_Mouse1.22807774
61* MAF_26560356_Chip-Seq_TH2_Human1.18780102
62GATA1_22025678_ChIP-Seq_K562_Human1.18638288
63* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.17731138
64STAT6_21828071_ChIP-Seq_BEAS2B_Human1.16878422
65ELF1_17652178_ChIP-ChIP_JURKAT_Human1.16878053
66TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.15655780
67PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.14520641
68* KDM2B_26808549_Chip-Seq_REH_Human1.13258986
69FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.12878785
70CIITA_25753668_ChIP-Seq_RAJI_Human1.12187468
71GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.12094409
72* GATA3_26560356_Chip-Seq_TH1_Human1.12009806
73KDM2B_26808549_Chip-Seq_SUP-B15_Human1.11847969
74CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.10387739
75GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.10142121
76PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.09164014
77KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.09014358
78SPI1_23127762_ChIP-Seq_K562_Human1.07608955
79CBP_20019798_ChIP-Seq_JUKART_Human1.07442531
80IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.07442531
81REST_21632747_ChIP-Seq_MESCs_Mouse1.06661682
82VDR_22108803_ChIP-Seq_LS180_Human1.05220018
83* SMRT_27268052_Chip-Seq_Bcells_Human1.03209367
84RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.02474049
85PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.01954051
86TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.01244792
87GATA1_19941826_ChIP-Seq_K562_Human1.00646672
88GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00600493
89MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.00361076
90MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.00300459
91RARB_27405468_Chip-Seq_BRAIN_Mouse0.98746685
92SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.98095623
93FLI1_21867929_ChIP-Seq_TH2_Mouse0.96079317
94PCGF2_27294783_Chip-Seq_ESCs_Mouse0.95847219
95SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.95318132
96GATA1_19941827_ChIP-Seq_MEL86_Mouse0.94748564
97CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.94147009
98VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.93903023
99RUNX1_22412390_ChIP-Seq_EML_Mouse0.91990237
100SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.91895373
101PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.91588566
102TBX20_22328084_ChIP-Seq_HEART_Mouse0.91536739
103TBX20_22080862_ChIP-Seq_HEART_Mouse0.91536739
104ELK3_25401928_ChIP-Seq_HUVEC_Human0.91501499
105VDR_24787735_ChIP-Seq_THP-1_Human0.91242205
106TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.90379776
107SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.90021899
108PU.1_20513432_ChIP-Seq_Bcells_Mouse0.88264538
109CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.86654798
110MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.86478558
111* GATA3_26560356_Chip-Seq_TH2_Human0.85891621
112* TCF4_23295773_ChIP-Seq_U87_Human0.85733096
113TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.84521717
114THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.84473466
115CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.84080498
116VDR_24763502_ChIP-Seq_THP-1_Human0.84023826
117* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.83722519
118TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.83502148
119SMAD_19615063_ChIP-ChIP_OVARY_Human0.82326094
120PCGF2_27294783_Chip-Seq_NPCs_Mouse0.81604430
121TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.81293515
122VDR_21846776_ChIP-Seq_THP-1_Human0.81121585
123TAF15_26573619_Chip-Seq_HEK293_Human0.80109555
124SMAD4_21799915_ChIP-Seq_A2780_Human0.80035621
125GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.79226271
126GATA1_22383799_ChIP-Seq_G1ME_Mouse0.79009265
127TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.78349273
128KDM2B_26808549_Chip-Seq_JURKAT_Human0.78039035
129LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.78004051
130P53_21459846_ChIP-Seq_SAOS-2_Human0.77819059
131TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.77508059
132TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.77140491
133POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.77140491
134TFEB_21752829_ChIP-Seq_HELA_Human0.76739894
135BRD4_27068464_Chip-Seq_AML-cells_Mouse0.76451864
136RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.76336357
137ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.75942994
138TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.75438382
139TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.75326546
140NOTCH1_21737748_ChIP-Seq_TLL_Human0.75209690
141STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.74949815
142SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.74565425
143TBL1_22424771_ChIP-Seq_293T_Human0.74489976
144GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.74417150
145LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.74132415
146GATA2_19941826_ChIP-Seq_K562_Human0.74019059
147EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.73435872
148RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.71645305
149NFIB_24661679_ChIP-Seq_LUNG_Mouse0.71607930

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005410_abnormal_fertilization7.94519132
2MP0003724_increased_susceptibility_to3.18538450
3MP0003763_abnormal_thymus_physiology2.87768256
4MP0003646_muscle_fatigue2.86668524
5MP0003698_abnormal_male_reproductive2.84124177
6MP0005387_immune_system_phenotype2.77075386
7MP0001790_abnormal_immune_system2.77075386
8MP0005671_abnormal_response_to2.74804719
9MP0001800_abnormal_humoral_immune2.70407333
10MP0001929_abnormal_gametogenesis2.64699423
11MP0008877_abnormal_DNA_methylation2.64200835
12MP0005551_abnormal_eye_electrophysiolog2.50412075
13MP0004510_myositis2.48103061
14MP0001835_abnormal_antigen_presentation2.40215354
15MP0000685_abnormal_immune_system2.27793180
16MP0005451_abnormal_body_composition2.09545978
17MP0002723_abnormal_immune_serum2.01899886
18MP0002452_abnormal_antigen_presenting1.97610091
19MP0004036_abnormal_muscle_relaxation1.97230221
20MP0002420_abnormal_adaptive_immunity1.96927358
21MP0001819_abnormal_immune_cell1.91431193
22MP0002398_abnormal_bone_marrow1.88747302
23MP0002332_abnormal_exercise_endurance1.85262080
24MP0002166_altered_tumor_susceptibility1.84134454
25MP0005000_abnormal_immune_tolerance1.79275974
26MP0005253_abnormal_eye_physiology1.67249023
27MP0003303_peritoneal_inflammation1.66525356
28MP0006072_abnormal_retinal_apoptosis1.66040882
29MP0001533_abnormal_skeleton_physiology1.65933207
30MP0000716_abnormal_immune_system1.65401507
31MP0003300_gastrointestinal_ulcer1.63133905
32MP0008961_abnormal_basal_metabolism1.62975707
33MP0003950_abnormal_plasma_membrane1.62463591
34MP0003011_delayed_dark_adaptation1.60097046
35MP0001984_abnormal_olfaction1.58161528
36MP0004233_abnormal_muscle_weight1.57968365
37MP0005464_abnormal_platelet_physiology1.56982861
38MP0005058_abnormal_lysosome_morphology1.56298972
39MP0009764_decreased_sensitivity_to1.50744587
40MP0009278_abnormal_bone_marrow1.49429854
41MP0000703_abnormal_thymus_morphology1.48389099
42MP0000751_myopathy1.46646167
43MP0003045_fibrosis1.43870150
44MP0000689_abnormal_spleen_morphology1.43342603
45MP0002161_abnormal_fertility/fecundity1.42530561
46MP0002837_dystrophic_cardiac_calcinosis1.42015609
47MP0002405_respiratory_system_inflammati1.40897171
48MP0003656_abnormal_erythrocyte_physiolo1.39786715
49MP0008260_abnormal_autophagy1.39120190
50MP0002210_abnormal_sex_determination1.37312125
51MP0009840_abnormal_foam_cell1.32845746
52MP0008469_abnormal_protein_level1.31923275
53MP0002722_abnormal_immune_system1.31282148
54MP0004859_abnormal_synaptic_plasticity1.31020872
55MP0001853_heart_inflammation1.30957782
56MP0002998_abnormal_bone_remodeling1.28380117
57MP0000343_altered_response_to1.28172875
58MP0002006_tumorigenesis1.27603975
59MP0005397_hematopoietic_system_phenotyp1.25895987
60MP0001545_abnormal_hematopoietic_system1.25895987
61MP0004084_abnormal_cardiac_muscle1.24116970
62MP0004484_altered_response_of1.23828340
63MP0002429_abnormal_blood_cell1.22920510
64MP0001873_stomach_inflammation1.22810829
65MP0003329_amyloid_beta_deposits1.21848065
66MP0003172_abnormal_lysosome_physiology1.21639372
67MP0000465_gastrointestinal_hemorrhage1.20611784
68MP0005166_decreased_susceptibility_to1.18756585
69MP0006082_CNS_inflammation1.15469393
70MP0003075_altered_response_to1.15454173
71MP0003828_pulmonary_edema1.14138303
72MP0005025_abnormal_response_to1.12885744
73MP0008569_lethality_at_weaning1.12469277
74MP0003091_abnormal_cell_migration1.10912372
75MP0003191_abnormal_cellular_cholesterol1.10146500
76MP0003866_abnormal_defecation1.10013064
77MP0002009_preneoplasia1.09878906
78MP0001145_abnormal_male_reproductive1.09796169
79MP0009785_altered_susceptibility_to1.08978971
80MP0004808_abnormal_hematopoietic_stem1.06740819
81MP0000858_altered_metastatic_potential1.05726610
82MP0004087_abnormal_muscle_fiber1.05603352
83MP0004145_abnormal_muscle_electrophysio1.04565060
84MP0002735_abnormal_chemical_nociception1.02363960
85MP0004130_abnormal_muscle_cell1.01812964
86MP0003448_altered_tumor_morphology0.98822534
87MP0004270_analgesia0.98344101
88MP0002229_neurodegeneration0.98047690
89MP0002138_abnormal_hepatobiliary_system0.97894610
90MP0002933_joint_inflammation0.96184345
91MP0000653_abnormal_sex_gland0.96117097
92MP0008004_abnormal_stomach_pH0.95491846
93MP0004947_skin_inflammation0.93743906
94MP0009333_abnormal_splenocyte_physiolog0.91088242
95MP0001765_abnormal_ion_homeostasis0.90837078
96MP0008874_decreased_physiological_sensi0.88947600
97MP0003221_abnormal_cardiomyocyte_apopto0.88244275
98MP0000749_muscle_degeneration0.88026440
99MP0005167_abnormal_blood-brain_barrier0.87431847
100MP0010630_abnormal_cardiac_muscle0.86890878
101MP0005310_abnormal_salivary_gland0.86719433
102MP0004215_abnormal_myocardial_fiber0.85298077
103MP0005164_abnormal_response_to0.84541748
104MP0003635_abnormal_synaptic_transmissio0.84192178
105MP0003880_abnormal_central_pattern0.83558874
106MP0001968_abnormal_touch/_nociception0.82199165
107MP0000920_abnormal_myelination0.81388958
108MP0000604_amyloidosis0.80222545
109MP0002106_abnormal_muscle_physiology0.79848098
110MP0001845_abnormal_inflammatory_respons0.79642833
111MP0005266_abnormal_metabolism0.79413108
112MP0004883_abnormal_blood_vessel0.78571761
113MP0001851_eye_inflammation0.78076879
114MP0000249_abnormal_blood_vessel0.77983470
115MP0009763_increased_sensitivity_to0.77869819
116MP0002653_abnormal_ependyma_morphology0.77630662
117MP0002419_abnormal_innate_immunity0.77573805
118MP0003690_abnormal_glial_cell0.77555869
119MP0010155_abnormal_intestine_physiology0.76251469
120MP0002928_abnormal_bile_duct0.74656987
121MP0003279_aneurysm0.74048852
122MP0001502_abnormal_circadian_rhythm0.73696746
123MP0005195_abnormal_posterior_eye0.71527837
124MP0005165_increased_susceptibility_to0.71466736
125MP0005423_abnormal_somatic_nervous0.71126813
126MP0005330_cardiomyopathy0.70941260
127MP0000759_abnormal_skeletal_muscle0.69064371
128MP0005390_skeleton_phenotype0.68593630
129MP0005623_abnormal_meninges_morphology0.68400825
130MP0001986_abnormal_taste_sensitivity0.68214554
131MP0002148_abnormal_hypersensitivity_rea0.66961594
132MP0006054_spinal_hemorrhage0.66855791
133MP0003633_abnormal_nervous_system0.66841457
134MP0000747_muscle_weakness0.65888419
135MP0005620_abnormal_muscle_contractility0.65639626
136MP0009046_muscle_twitch0.64585602
137MP0002090_abnormal_vision0.63931710
138MP0003436_decreased_susceptibility_to0.63849906
139MP0002064_seizures0.63581936
140MP0003787_abnormal_imprinting0.63305738
141MP0002160_abnormal_reproductive_system0.62123301
142MP0009745_abnormal_behavioral_response0.61747548
143MP0001661_extended_life_span0.61738096

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)7.60376014
2Dynein arm defect of respiratory motile cilia (HP:0012255)7.23469795
3Absent/shortened dynein arms (HP:0200106)7.23469795
4Nasal polyposis (HP:0100582)6.30407159
5Recurrent bronchitis (HP:0002837)5.49747610
6Recurrent sinusitis (HP:0011108)5.32179650
7Abnormal respiratory motile cilium physiology (HP:0012261)5.09290508
8Abnormality of the nasal mucosa (HP:0000433)5.09201478
9Rhinitis (HP:0012384)4.91995178
10Bronchitis (HP:0012387)4.82825668
11Abnormal respiratory epithelium morphology (HP:0012253)4.46123290
12Abnormal respiratory motile cilium morphology (HP:0005938)4.46123290
13Eczematoid dermatitis (HP:0000976)4.45034243
14Agammaglobulinemia (HP:0004432)4.07953788
15Muscle fiber inclusion bodies (HP:0100299)4.01094094
16Recurrent otitis media (HP:0000403)3.96938102
17Bony spicule pigmentary retinopathy (HP:0007737)3.96911649
18Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.95010033
19Nemaline bodies (HP:0003798)3.94578786
20Recurrent bacterial skin infections (HP:0005406)3.91796226
21Bronchiectasis (HP:0002110)3.89756168
22Chronic bronchitis (HP:0004469)3.82442754
23Abnormal ciliary motility (HP:0012262)3.75561062
24Infertility (HP:0000789)3.71075409
25Elevated erythrocyte sedimentation rate (HP:0003565)3.69099435
26Mediastinal lymphadenopathy (HP:0100721)3.68984797
27Congenital stationary night blindness (HP:0007642)3.65457753
28Dyschromatopsia (HP:0007641)3.58359386
29Absent rod-and cone-mediated responses on ERG (HP:0007688)3.55624604
30Recurrent abscess formation (HP:0002722)3.50885607
31Abnormality of macrophages (HP:0004311)3.44160321
32Orchitis (HP:0100796)3.43601137
33Chronic sinusitis (HP:0011109)3.40043426
34Increased IgM level (HP:0003496)3.34449626
35Central scotoma (HP:0000603)3.22808470
36Inflammation of the large intestine (HP:0002037)3.20212196
37Colitis (HP:0002583)3.19056883
38Gastrointestinal stroma tumor (HP:0100723)3.09226942
39Autoimmune hemolytic anemia (HP:0001890)3.08602929
40Gastrointestinal inflammation (HP:0004386)3.03274079
41Abnormal rod and cone electroretinograms (HP:0008323)3.01689578
42Exercise-induced myalgia (HP:0003738)2.98035600
43Chronic otitis media (HP:0000389)2.95438444
44T lymphocytopenia (HP:0005403)2.94786059
45Gastrointestinal infarctions (HP:0005244)2.92727329
46Papilloma (HP:0012740)2.92489313
47Verrucae (HP:0200043)2.92489313
48Type 1 muscle fiber predominance (HP:0003803)2.90723433
49Abnormality of glycosphingolipid metabolism (HP:0004343)2.88603833
50Abnormality of glycolipid metabolism (HP:0010969)2.88603833
51Abnormality of liposaccharide metabolism (HP:0010968)2.88603833
52Pulmonary infiltrates (HP:0002113)2.88596764
53Eosinophilia (HP:0001880)2.84866071
54Recurrent skin infections (HP:0001581)2.80856697
55Abnormality of T cell number (HP:0011839)2.79514787
56Encephalitis (HP:0002383)2.78778273
57Granulocytopenia (HP:0001913)2.75880983
58Spontaneous hematomas (HP:0007420)2.75188463
59Autoimmune thrombocytopenia (HP:0001973)2.70911082
60Keratoconjunctivitis sicca (HP:0001097)2.69710034
61EMG: myopathic abnormalities (HP:0003458)2.69642009
62Centrally nucleated skeletal muscle fibers (HP:0003687)2.68042934
63Combined immunodeficiency (HP:0005387)2.67666086
64Panhypogammaglobulinemia (HP:0003139)2.66845446
65Leukocytosis (HP:0001974)2.61217548
66IgM deficiency (HP:0002850)2.61182304
67Nephronophthisis (HP:0000090)2.61087366
68Chest pain (HP:0100749)2.50480646
69Abnormality of eosinophils (HP:0001879)2.50473747
70Scotoma (HP:0000575)2.49461471
71Hematochezia (HP:0002573)2.49343057
72Pustule (HP:0200039)2.47734423
73Recurrent viral infections (HP:0004429)2.47591457
74Abolished electroretinogram (ERG) (HP:0000550)2.47486529
75Rhabdomyolysis (HP:0003201)2.47377219
76Abnormality of macular pigmentation (HP:0008002)2.47238174
77Hypergammaglobulinemia (HP:0010702)2.45651071
78Abnormal delayed hypersensitivity skin test (HP:0002963)2.45605499
79Recurrent gram-negative bacterial infections (HP:0005420)2.43837874
80Constricted visual fields (HP:0001133)2.41024284
81Keratoconjunctivitis (HP:0001096)2.40037821
82Hemoptysis (HP:0002105)2.40033977
83Pigmentary retinal degeneration (HP:0001146)2.37264701
84Obstructive lung disease (HP:0006536)2.35533512
85Chronic obstructive pulmonary disease (HP:0006510)2.35533512
86Hyporeflexia of lower limbs (HP:0002600)2.34388611
87Lymphopenia (HP:0001888)2.34252956
88Increased IgE level (HP:0003212)2.33358624
89Attenuation of retinal blood vessels (HP:0007843)2.32769970
90Muscle fiber splitting (HP:0003555)2.32659098
91Abnormality of T cells (HP:0002843)2.31744501
92Abnormality of B cell number (HP:0010975)2.29034611
93B lymphocytopenia (HP:0010976)2.29034611
94Meningitis (HP:0001287)2.27026191
95Abnormality of skeletal muscle fiber size (HP:0012084)2.25768193
96Gingivitis (HP:0000230)2.20427869
97Abnormality of cells of the lymphoid lineage (HP:0012140)2.19633013
98Cellulitis (HP:0100658)2.19314048
99Type II diabetes mellitus (HP:0005978)2.18186590
100Asymmetric septal hypertrophy (HP:0001670)2.17940076
101Choroideremia (HP:0001139)2.15375719
102Dysostosis multiplex (HP:0000943)2.12382341
103Thyroiditis (HP:0100646)2.11500999
104Exercise-induced muscle cramps (HP:0003710)2.07817255
105Bundle branch block (HP:0011710)2.04786442
106Severe visual impairment (HP:0001141)2.03477218
107Urticaria (HP:0001025)2.03015467
108Vasculitis (HP:0002633)2.01850085
109Amyotrophic lateral sclerosis (HP:0007354)2.01681208
110Frequent falls (HP:0002359)2.01002090
111Dysmetric saccades (HP:0000641)2.00125907
112Decreased central vision (HP:0007663)1.98926010
113Rimmed vacuoles (HP:0003805)1.98259351
114Neck muscle weakness (HP:0000467)1.98145912
115Distal arthrogryposis (HP:0005684)1.97659734
116Arterial thrombosis (HP:0004420)1.94993805
117Photophobia (HP:0000613)1.94149080
118Osteomyelitis (HP:0002754)1.93366162
119Increased variability in muscle fiber diameter (HP:0003557)1.92950354
120Posterior subcapsular cataract (HP:0007787)1.92732361
121Abnormality of the renal medulla (HP:0100957)1.92200854
122Polyneuropathy (HP:0001271)1.90180672
123Emphysema (HP:0002097)1.90102509
124Gangrene (HP:0100758)1.89918412
125Chronic diarrhea (HP:0002028)1.89413441
126Loss of speech (HP:0002371)1.88859507
127Ulnar deviation of the wrist (HP:0003049)1.88536986
128Abnormality of the pleura (HP:0002103)1.88468773
129Recurrent fungal infections (HP:0002841)1.87809446
130Optic neuritis (HP:0100653)1.87391161
131Retrobulbar optic neuritis (HP:0100654)1.87391161
132Chronic mucocutaneous candidiasis (HP:0002728)1.84767855
133Recurrent cutaneous fungal infections (HP:0011370)1.84767855
134Calf muscle hypertrophy (HP:0008981)1.83653380
135Medial flaring of the eyebrow (HP:0010747)1.83576302
136Myositis (HP:0100614)1.82599897
137Urinary urgency (HP:0000012)1.79384935
138Myoglobinuria (HP:0002913)1.76388214
139Severe combined immunodeficiency (HP:0004430)1.75313942
140IgA deficiency (HP:0002720)1.74836826
141IgG deficiency (HP:0004315)1.73910267
142Muscle hypertrophy of the lower extremities (HP:0008968)1.73573184
143Abnormality of the fingertips (HP:0001211)1.73434184
144Chorioretinal atrophy (HP:0000533)1.73099441
145Hypoplasia of the capital femoral epiphysis (HP:0003090)1.71854153
146Macular degeneration (HP:0000608)1.70725841
147Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.70230185
148Degeneration of the lateral corticospinal tracts (HP:0002314)1.70230185
149Decreased electroretinogram (ERG) amplitude (HP:0000654)1.69207658
150Abnormality of T cell physiology (HP:0011840)1.67740590
151Sudden death (HP:0001699)1.67600583
152Fatigue (HP:0012378)1.66768126
153Pendular nystagmus (HP:0012043)1.65698991
154Retinitis pigmentosa (HP:0000510)1.64890256
155Abnormality of the lower motor neuron (HP:0002366)1.62119873
156Difficulty running (HP:0009046)1.61611211
157Stomatitis (HP:0010280)1.61520182
158Restrictive lung disease (HP:0002091)1.61127210

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK35.66678701
2PDK45.66678701
3MAP4K14.46180285
4PDK23.42787023
5PRKD32.72339381
6TESK12.68320331
7PRPF4B2.43185024
8MAP3K102.26652256
9ICK2.25144461
10BLK2.10003190
11WNK42.05179455
12TAOK32.03446849
13STK391.95635439
14TXK1.93579237
15MAP2K31.90549767
16IRAK41.81445145
17PTK2B1.80955993
18GRK61.77457774
19ITK1.74568538
20GRK71.71538143
21TAOK21.62518069
22PDK11.59363390
23WNK11.56938579
24TESK21.56014006
25JAK11.54609990
26IKBKB1.54539294
27JAK31.46618274
28CAMKK21.46495222
29PRKCH1.46434116
30BMPR21.44511866
31MAP3K31.42282894
32TRIB31.42239271
33EEF2K1.41746106
34MAP3K111.35044139
35TGFBR21.32907732
36RIPK41.32265922
37STK381.31509246
38SIK21.29865286
39IRAK31.27665594
40SYK1.27659388
41PIK3CG1.25373657
42EPHB11.25032497
43PRKCQ1.24762793
44TTN1.24722700
45PKN21.20550234
46MOS1.20462999
47FGFR31.19685817
48TYK21.12845107
49STK101.11768251
50MAP3K11.11419021
51TAOK11.02226070
52FGFR40.99319959
53TBK10.99136782
54MARK20.98835916
55ARAF0.97799694
56SIK30.96468650
57FGR0.95888649
58PIM20.95312383
59NEK20.94589393
60ZAP700.94368177
61CAMK1G0.90769603
62NME20.90498733
63IKBKE0.89684802
64LCK0.89657171
65CLK10.87889716
66GRK10.87861304
67CSF1R0.86060102
68MAP3K130.85924436
69MARK30.85157941
70CDC42BPA0.84552200
71NEK90.83215458
72MAPK110.83060203
73MAP3K140.80570565
74BTK0.80471323
75PHKG10.80210792
76PHKG20.80210792
77LMTK20.79877921
78MAP3K50.78930653
79HCK0.77200411
80PDPK10.76537823
81MAPK120.76505718
82PNCK0.76393229
83NTRK30.75820038
84FES0.74933882
85FGFR20.74871581
86MAP3K70.74192543
87CSK0.67862134
88PRKD20.67389883
89SCYL20.66050849
90LRRK20.64725686
91TRPM70.64489212
92NTRK20.63542399
93RIPK10.63457955
94MAPK40.62227370
95DMPK0.62059054
96CHUK0.61413742
97DYRK1B0.61254660
98MATK0.60486939
99EPHA30.59828050
100TYRO30.59743340
101RAF10.58331703
102NLK0.57135235
103ERN10.56228705
104CDK120.55529375
105HIPK20.54650672
106MAP3K90.52926545
107MAP3K20.50860617
108CAMKK10.48940041
109SGK30.48508826
110RET0.48276699
111MAPKAPK30.47161642
112TNIK0.46206566
113MAPK70.45783766
114CAMK40.43923532
115IRAK10.43432563
116PRKD10.40974673
117KIT0.40328574
118OBSCN0.39415638
119KSR20.38483893
120MELK0.37806994
121STK110.37272113
122RPS6KA50.36241879
123TEC0.35350236
124CSNK1D0.35034338
125PIM10.34799352
126PKN10.33601846
127EGFR0.33587716
128TNK20.33377598
129RPS6KL10.33152016
130RPS6KC10.33152016
131DDR20.32766782
132MST40.32584593
133KDR0.31591987
134STK240.31123698
135PAK60.29499056
136FYN0.29119480
137LYN0.29060130
138PINK10.29022893
139MAP3K40.28396997
140MAP2K60.27111465
141PRKAA10.25563647
142JAK20.24455631
143INSR0.24225098
144PAK30.22454824
145CDK50.22152109

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047444.39144463
2Primary immunodeficiency_Homo sapiens_hsa053404.09103441
3* B cell receptor signaling pathway_Homo sapiens_hsa046622.83491542
4Asthma_Homo sapiens_hsa053102.53371304
5* T cell receptor signaling pathway_Homo sapiens_hsa046602.38548162
6Toll-like receptor signaling pathway_Homo sapiens_hsa046202.22617434
7* Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.13929881
8RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.02844924
9Rheumatoid arthritis_Homo sapiens_hsa053232.00179358
10NOD-like receptor signaling pathway_Homo sapiens_hsa046211.89678124
11Antigen processing and presentation_Homo sapiens_hsa046121.77862251
12Malaria_Homo sapiens_hsa051441.77544023
13Staphylococcus aureus infection_Homo sapiens_hsa051501.75607472
14Intestinal immune network for IgA production_Homo sapiens_hsa046721.73797059
15* Tuberculosis_Homo sapiens_hsa051521.71177853
16Dorso-ventral axis formation_Homo sapiens_hsa043201.64072038
17Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.63418032
18Phosphatidylinositol signaling system_Homo sapiens_hsa040701.53554243
19Olfactory transduction_Homo sapiens_hsa047401.48864194
20Herpes simplex infection_Homo sapiens_hsa051681.47630868
21* Long-term potentiation_Homo sapiens_hsa047201.46110608
22* Glucagon signaling pathway_Homo sapiens_hsa049221.36978375
23Viral myocarditis_Homo sapiens_hsa054161.35650813
24Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.31961429
25* Osteoclast differentiation_Homo sapiens_hsa043801.31042107
26Measles_Homo sapiens_hsa051621.30983896
27Pertussis_Homo sapiens_hsa051331.30776183
28* cGMP-PKG signaling pathway_Homo sapiens_hsa040221.28773937
29Graft-versus-host disease_Homo sapiens_hsa053321.28412042
30Legionellosis_Homo sapiens_hsa051341.22846427
31NF-kappa B signaling pathway_Homo sapiens_hsa040641.21900049
32Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.20512852
33Carbohydrate digestion and absorption_Homo sapiens_hsa049731.20246844
34* VEGF signaling pathway_Homo sapiens_hsa043701.19257471
35Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.18157990
36Other glycan degradation_Homo sapiens_hsa005111.16845551
37Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.16069444
38Circadian entrainment_Homo sapiens_hsa047131.15690474
39Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.15489585
40Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.15288635
41Allograft rejection_Homo sapiens_hsa053301.12144912
42Pyruvate metabolism_Homo sapiens_hsa006201.10829655
43* Amphetamine addiction_Homo sapiens_hsa050311.10120614
44Insulin secretion_Homo sapiens_hsa049111.07129119
45Cardiac muscle contraction_Homo sapiens_hsa042601.06778399
46Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.04209585
47Chemokine signaling pathway_Homo sapiens_hsa040621.04174072
48Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.04103899
49Fatty acid biosynthesis_Homo sapiens_hsa000611.03971166
50Gastric acid secretion_Homo sapiens_hsa049711.03696320
51Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.03090417
52Inositol phosphate metabolism_Homo sapiens_hsa005621.02709714
53Aldosterone synthesis and secretion_Homo sapiens_hsa049251.02108386
54Hepatitis C_Homo sapiens_hsa051601.01801264
55Morphine addiction_Homo sapiens_hsa050321.01749455
56African trypanosomiasis_Homo sapiens_hsa051430.99622071
57Phagosome_Homo sapiens_hsa041450.99450082
58Autoimmune thyroid disease_Homo sapiens_hsa053200.98301184
59* Oxytocin signaling pathway_Homo sapiens_hsa049210.98025454
60Lysosome_Homo sapiens_hsa041420.97536411
61Toxoplasmosis_Homo sapiens_hsa051450.97134992
62Apoptosis_Homo sapiens_hsa042100.97027858
63* Renin secretion_Homo sapiens_hsa049240.96613614
64Estrogen signaling pathway_Homo sapiens_hsa049150.96414630
65Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.93906402
66Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.92828154
67Endocytosis_Homo sapiens_hsa041440.92432226
68Salivary secretion_Homo sapiens_hsa049700.89838669
69Jak-STAT signaling pathway_Homo sapiens_hsa046300.89758451
70AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.88784678
71Thyroid hormone signaling pathway_Homo sapiens_hsa049190.88500298
72cAMP signaling pathway_Homo sapiens_hsa040240.88333283
73Epstein-Barr virus infection_Homo sapiens_hsa051690.87821234
74Cholinergic synapse_Homo sapiens_hsa047250.82910721
75Hematopoietic cell lineage_Homo sapiens_hsa046400.82631647
76Glycerolipid metabolism_Homo sapiens_hsa005610.81706123
77Dilated cardiomyopathy_Homo sapiens_hsa054140.81448487
78Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.79020350
79* Dopaminergic synapse_Homo sapiens_hsa047280.78168666
80* MAPK signaling pathway_Homo sapiens_hsa040100.77963840
81* Calcium signaling pathway_Homo sapiens_hsa040200.77500564
82Neurotrophin signaling pathway_Homo sapiens_hsa047220.76789779
83Type II diabetes mellitus_Homo sapiens_hsa049300.76206598
84Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.76196027
85FoxO signaling pathway_Homo sapiens_hsa040680.76001147
86Synaptic vesicle cycle_Homo sapiens_hsa047210.74625527
87mTOR signaling pathway_Homo sapiens_hsa041500.72974760
88Renal cell carcinoma_Homo sapiens_hsa052110.72748206
89* Glutamatergic synapse_Homo sapiens_hsa047240.72700525
90Adipocytokine signaling pathway_Homo sapiens_hsa049200.72486725
91Glioma_Homo sapiens_hsa052140.71292883
92Glycosaminoglycan degradation_Homo sapiens_hsa005310.71059794
93Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.70173248
94Viral carcinogenesis_Homo sapiens_hsa052030.69923468
95Leishmaniasis_Homo sapiens_hsa051400.69729811
96Propanoate metabolism_Homo sapiens_hsa006400.69563021
97Vascular smooth muscle contraction_Homo sapiens_hsa042700.69347119
98* HTLV-I infection_Homo sapiens_hsa051660.68647465
99Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.68333670
100Sphingolipid signaling pathway_Homo sapiens_hsa040710.67387000
101Insulin resistance_Homo sapiens_hsa049310.66873889
102Systemic lupus erythematosus_Homo sapiens_hsa053220.66569010
103Acute myeloid leukemia_Homo sapiens_hsa052210.66507031
104Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.66174063
105Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.66153424
106Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.63781896
107Hepatitis B_Homo sapiens_hsa051610.62675312
108HIF-1 signaling pathway_Homo sapiens_hsa040660.61135315
109Leukocyte transendothelial migration_Homo sapiens_hsa046700.60554685
110Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.60024456
111Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.58859464
112Transcriptional misregulation in cancer_Homo sapiens_hsa052020.58006279
113Pancreatic secretion_Homo sapiens_hsa049720.57780342
114Chronic myeloid leukemia_Homo sapiens_hsa052200.56492656
115Type I diabetes mellitus_Homo sapiens_hsa049400.56403214
116Phospholipase D signaling pathway_Homo sapiens_hsa040720.55922218
117Prolactin signaling pathway_Homo sapiens_hsa049170.55763744
118Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.55585450
119Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.54700953
120Non-small cell lung cancer_Homo sapiens_hsa052230.54102565
121Pancreatic cancer_Homo sapiens_hsa052120.53740071
122Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.53252106
123Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.51579332
124Choline metabolism in cancer_Homo sapiens_hsa052310.51363330
125Thyroid hormone synthesis_Homo sapiens_hsa049180.51355937
126Shigellosis_Homo sapiens_hsa051310.51227572
127Glycerophospholipid metabolism_Homo sapiens_hsa005640.50932844
128Platelet activation_Homo sapiens_hsa046110.49240429
129Circadian rhythm_Homo sapiens_hsa047100.49059458
130Influenza A_Homo sapiens_hsa051640.48363523
131Salmonella infection_Homo sapiens_hsa051320.48337638
132TNF signaling pathway_Homo sapiens_hsa046680.47783238
133Regulation of autophagy_Homo sapiens_hsa041400.47535673
134Amoebiasis_Homo sapiens_hsa051460.46946394
135SNARE interactions in vesicular transport_Homo sapiens_hsa041300.46701166
136* Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.44639353
137Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.40093198
138GnRH signaling pathway_Homo sapiens_hsa049120.39432678
139Insulin signaling pathway_Homo sapiens_hsa049100.32440840
140Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.32392432
141Prion diseases_Homo sapiens_hsa050200.29467782
142Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.26675423
143Colorectal cancer_Homo sapiens_hsa052100.25229071
144ErbB signaling pathway_Homo sapiens_hsa040120.22948223

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »