PPP3R1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)6.24565814
2regulation of short-term neuronal synaptic plasticity (GO:0048172)6.19828215
3locomotory exploration behavior (GO:0035641)6.02239200
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.91423756
5synaptic vesicle exocytosis (GO:0016079)5.69496861
6positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.44987503
7glutamate secretion (GO:0014047)5.37415211
8vocalization behavior (GO:0071625)5.33995363
9regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.30687227
10synaptic vesicle docking involved in exocytosis (GO:0016081)5.20418369
11regulation of synaptic vesicle exocytosis (GO:2000300)5.17355243
12regulation of glutamate receptor signaling pathway (GO:1900449)5.09652468
13ionotropic glutamate receptor signaling pathway (GO:0035235)4.87119551
14regulation of long-term neuronal synaptic plasticity (GO:0048169)4.85235476
15regulation of neuronal synaptic plasticity (GO:0048168)4.80663905
16neuronal action potential propagation (GO:0019227)4.77516502
17exploration behavior (GO:0035640)4.75419493
18protein localization to synapse (GO:0035418)4.72388955
19regulation of synaptic vesicle transport (GO:1902803)4.67311681
20regulation of synapse structural plasticity (GO:0051823)4.55710051
21cerebellar granule cell differentiation (GO:0021707)4.42617347
22neurotransmitter secretion (GO:0007269)4.36800843
23glutamate receptor signaling pathway (GO:0007215)4.33706292
24regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.31047225
25synaptic transmission, glutamatergic (GO:0035249)4.26816411
26dendritic spine morphogenesis (GO:0060997)4.12121698
27neuron-neuron synaptic transmission (GO:0007270)4.09934420
28layer formation in cerebral cortex (GO:0021819)4.09741848
29regulation of excitatory postsynaptic membrane potential (GO:0060079)4.08909837
30long-term memory (GO:0007616)4.08551518
31cellular potassium ion homeostasis (GO:0030007)4.04834147
32regulation of dendritic spine morphogenesis (GO:0061001)4.02262520
33neurotransmitter-gated ion channel clustering (GO:0072578)3.98419054
34regulation of synaptic plasticity (GO:0048167)3.97916137
35membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.96626385
36positive regulation of membrane potential (GO:0045838)3.92148284
37neuron cell-cell adhesion (GO:0007158)3.89341528
38cytoskeletal anchoring at plasma membrane (GO:0007016)3.86301002
39regulation of postsynaptic membrane potential (GO:0060078)3.82756964
40long-term synaptic potentiation (GO:0060291)3.79955866
41amino acid import (GO:0043090)3.79034729
42G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.78031917
43negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.75692802
44sodium ion export (GO:0071436)3.69299142
45activation of protein kinase A activity (GO:0034199)3.68161095
46negative regulation of dendrite morphogenesis (GO:0050774)3.68060407
47positive regulation of synapse maturation (GO:0090129)3.66573673
48proline transport (GO:0015824)3.66439077
49neuromuscular process controlling balance (GO:0050885)3.59922758
50synaptic vesicle endocytosis (GO:0048488)3.52675038
51gamma-aminobutyric acid signaling pathway (GO:0007214)3.52467438
52positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.50070984
53positive regulation of neurotransmitter secretion (GO:0001956)3.49068743
54gamma-aminobutyric acid transport (GO:0015812)3.46476432
55neurotransmitter transport (GO:0006836)3.46002854
56behavioral fear response (GO:0001662)3.45139883
57behavioral defense response (GO:0002209)3.45139883
58regulation of neurotransmitter secretion (GO:0046928)3.42367143
59dendritic spine organization (GO:0097061)3.41349271
60regulation of synaptic transmission, glutamatergic (GO:0051966)3.39885895
61vesicle transport along microtubule (GO:0047496)3.38897254
62positive regulation of neurotransmitter transport (GO:0051590)3.37050609
63regulation of vesicle fusion (GO:0031338)3.36171110
64regulation of dendritic spine development (GO:0060998)3.34961748
65neuron recognition (GO:0008038)3.34665447
66cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.33837997
67response to histamine (GO:0034776)3.33347036
68protein localization to endosome (GO:0036010)3.30766826
69transmission of nerve impulse (GO:0019226)3.28808200
70potassium ion homeostasis (GO:0055075)3.26998699
71regulation of neurotransmitter levels (GO:0001505)3.24794352
72innervation (GO:0060384)3.24418163
73positive regulation of synaptic transmission, GABAergic (GO:0032230)3.24368723
74positive regulation of dendritic spine morphogenesis (GO:0061003)3.21808763
75negative regulation of synaptic transmission, GABAergic (GO:0032229)3.20836552
76fear response (GO:0042596)3.20672724
77chemosensory behavior (GO:0007635)3.20586717
78regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.20411076
79long term synaptic depression (GO:0060292)3.20315524
80negative regulation of erythrocyte differentiation (GO:0045647)3.20196529
81membrane depolarization (GO:0051899)3.20099623
82positive regulation of Rap GTPase activity (GO:0032854)3.19875225
83regulation of neurotransmitter transport (GO:0051588)3.17579687
84cell communication by electrical coupling (GO:0010644)3.16559012
85potassium ion import (GO:0010107)3.15758346
86positive regulation of dendritic spine development (GO:0060999)3.15138071
87prepulse inhibition (GO:0060134)3.13446919
88positive regulation of synaptic transmission (GO:0050806)3.12455059
89learning (GO:0007612)3.12033984
90regulation of synaptic transmission (GO:0050804)3.09388094
91regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.06950749
92G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.06340712
93neuromuscular process controlling posture (GO:0050884)3.04959642
94axonal fasciculation (GO:0007413)3.04696950
95regulation of ARF protein signal transduction (GO:0032012)3.03849389
96membrane depolarization during action potential (GO:0086010)3.03592077
97positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.03520628
98regulation of voltage-gated calcium channel activity (GO:1901385)3.02074227
99auditory behavior (GO:0031223)3.02061593
100positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.01084946
101regulation of female receptivity (GO:0045924)2.99845507
102cerebellar Purkinje cell differentiation (GO:0021702)2.99675652
103synaptic transmission (GO:0007268)2.99416446
104response to auditory stimulus (GO:0010996)2.99332586
105neuromuscular process (GO:0050905)2.98584268
106neuronal ion channel clustering (GO:0045161)2.94547166
107membrane hyperpolarization (GO:0060081)2.94427421
108regulation of glutamate secretion (GO:0014048)2.93794422
109behavioral response to cocaine (GO:0048148)2.93738107
110cellular sodium ion homeostasis (GO:0006883)2.93242925
111negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.92681994
112L-amino acid import (GO:0043092)2.92349204
113positive regulation of fibroblast migration (GO:0010763)2.86913915
114regulation of Rap GTPase activity (GO:0032317)2.83427088
115clathrin coat assembly (GO:0048268)2.78475851
116cortical actin cytoskeleton organization (GO:0030866)2.78007464
117regulation of early endosome to late endosome transport (GO:2000641)2.76362529
118signal complex assembly (GO:0007172)2.76170369
119regulation of synapse maturation (GO:0090128)2.71717287
120cellular response to monoamine stimulus (GO:0071868)2.68148199
121cellular response to catecholamine stimulus (GO:0071870)2.68148199
122peptidyl-threonine phosphorylation (GO:0018107)2.66480440
123regulation of beta-amyloid formation (GO:1902003)2.63817055
124cell differentiation in hindbrain (GO:0021533)2.62521157
125mating behavior (GO:0007617)2.60052893
126negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.58971377
127negative regulation of cell killing (GO:0031342)2.58971377
128vesicle docking involved in exocytosis (GO:0006904)2.57116989
129regulation of amyloid precursor protein catabolic process (GO:1902991)2.53432967
130peptidyl-threonine modification (GO:0018210)2.51370729
131regulation of exocytosis (GO:0017157)2.46272669
132cell communication involved in cardiac conduction (GO:0086065)2.43617075
133protein targeting to plasma membrane (GO:0072661)2.41517124
134regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.40547700
135regulation of clathrin-mediated endocytosis (GO:2000369)2.38755607
136positive regulation of protein dephosphorylation (GO:0035307)2.37686338
137regulation of ARF GTPase activity (GO:0032312)2.37015601
138cortical cytoskeleton organization (GO:0030865)2.36694484
139regulation of regulated secretory pathway (GO:1903305)2.35020160
140positive regulation of receptor recycling (GO:0001921)2.34816321
141vesicle docking (GO:0048278)2.33229294
142negative regulation of inclusion body assembly (GO:0090084)2.30555340
143neurotransmitter uptake (GO:0001504)2.26478435

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.10784064
2NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.42815517
3GBX2_23144817_ChIP-Seq_PC3_Human3.35401129
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.19936956
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.12793732
6JARID2_20064375_ChIP-Seq_MESCs_Mouse3.11341056
7RARB_27405468_Chip-Seq_BRAIN_Mouse3.09437686
8THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse3.02715379
9REST_21632747_ChIP-Seq_MESCs_Mouse2.80522185
10RNF2_18974828_ChIP-Seq_MESCs_Mouse2.79902364
11EZH2_18974828_ChIP-Seq_MESCs_Mouse2.79902364
12SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.71518131
13JARID2_20075857_ChIP-Seq_MESCs_Mouse2.69098782
14MTF2_20144788_ChIP-Seq_MESCs_Mouse2.61644426
15DROSHA_22980978_ChIP-Seq_HELA_Human2.58827500
16SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.57991789
17KDM2B_26808549_Chip-Seq_SUP-B15_Human2.51923872
18SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.51405787
19SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.49698176
20EZH2_27304074_Chip-Seq_ESCs_Mouse2.36369544
21REST_18959480_ChIP-ChIP_MESCs_Mouse2.29185743
22IKZF1_21737484_ChIP-ChIP_HCT116_Human2.27292141
23SUZ12_27294783_Chip-Seq_ESCs_Mouse2.26331443
24RNF2_27304074_Chip-Seq_ESCs_Mouse2.20751611
25EZH2_27294783_Chip-Seq_ESCs_Mouse2.20062610
26TCF7_22412390_ChIP-Seq_EML_Mouse2.18355603
27EED_16625203_ChIP-ChIP_MESCs_Mouse2.16236542
28MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.15039603
29KDM2B_26808549_Chip-Seq_DND41_Human2.08081927
30EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.95091380
31EGR1_19374776_ChIP-ChIP_THP-1_Human1.94624159
32* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.90384618
33ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.88465410
34AR_21572438_ChIP-Seq_LNCaP_Human1.88139891
35CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.82326447
36MYC_22102868_ChIP-Seq_BL_Human1.77587596
37TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.76917515
38MYB_21317192_ChIP-Seq_ERMYB_Mouse1.72198264
39NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.70770350
40KDM2B_26808549_Chip-Seq_JURKAT_Human1.69682990
41LXR_22292898_ChIP-Seq_THP-1_Human1.66259230
42* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.65275329
43CTBP2_25329375_ChIP-Seq_LNCAP_Human1.63492202
44SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.63279897
45SMAD4_21799915_ChIP-Seq_A2780_Human1.62776500
46KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.60352746
47ERG_21242973_ChIP-ChIP_JURKAT_Human1.59627095
48CTBP1_25329375_ChIP-Seq_LNCAP_Human1.57578247
49ESR2_21235772_ChIP-Seq_MCF-7_Human1.56433352
50GATA1_19941826_ChIP-Seq_K562_Human1.56171958
51GATA1_19941827_ChIP-Seq_MEL_Mouse1.54153892
52SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.52797542
53SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.49524815
54GATA1_22025678_ChIP-Seq_K562_Human1.49488590
55TAF15_26573619_Chip-Seq_HEK293_Human1.46703716
56VDR_21846776_ChIP-Seq_THP-1_Human1.44173695
57FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.43293677
58GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.42257722
59NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.37692785
60* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.37558189
61SCL_19346495_ChIP-Seq_HPC-7_Human1.35079559
62ZNF274_21170338_ChIP-Seq_K562_Hela1.34093036
63FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.32740473
64DNAJC2_21179169_ChIP-ChIP_NT2_Human1.32554249
65SOX2_21211035_ChIP-Seq_LN229_Gbm1.32365078
66RING1B_27294783_Chip-Seq_ESCs_Mouse1.32326013
67RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.31995710
68SMAD_19615063_ChIP-ChIP_OVARY_Human1.31991992
69WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.31969401
70SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.31315905
71CLOCK_20551151_ChIP-Seq_293T_Human1.31289785
72STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.30802144
73SPI1_23127762_ChIP-Seq_K562_Human1.29626917
74MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.29565904
75NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.29018671
76VDR_24763502_ChIP-Seq_THP-1_Human1.28162375
77* ELK3_25401928_ChIP-Seq_HUVEC_Human1.28133531
78PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.27598297
79P300_27058665_Chip-Seq_ZR-75-30cells_Human1.27247375
80ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.26582859
81* P300_19829295_ChIP-Seq_ESCs_Human1.26502144
82AR_25329375_ChIP-Seq_VCAP_Human1.25212728
83WT1_25993318_ChIP-Seq_PODOCYTE_Human1.24164599
84ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.23459815
85SMAD3_21741376_ChIP-Seq_EPCs_Human1.23349811
86AR_19668381_ChIP-Seq_PC3_Human1.21942653
87BRD4_27068464_Chip-Seq_AML-cells_Mouse1.21300287
88EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.19733945
89PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.19247987
90ZFP57_27257070_Chip-Seq_ESCs_Mouse1.18741423
91ZFP281_18757296_ChIP-ChIP_E14_Mouse1.18066919
92SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.17787201
93STAT3_23295773_ChIP-Seq_U87_Human1.17200614
94CTNNB1_20460455_ChIP-Seq_HCT116_Human1.16998014
95* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.16784064
96KDM2B_26808549_Chip-Seq_K562_Human1.15549992
97STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.15133136
98SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.14697940
99TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.13111419
100P53_22127205_ChIP-Seq_FIBROBLAST_Human1.12221596
101RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.11993728
102ZNF217_24962896_ChIP-Seq_MCF-7_Human1.11691227
103TP53_16413492_ChIP-PET_HCT116_Human1.11334576
104OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.11211019
105GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.11049572
106RING1B_27294783_Chip-Seq_NPCs_Mouse1.10566114
107TOP2B_26459242_ChIP-Seq_MCF-7_Human1.10376874
108Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.10171766
109RACK7_27058665_Chip-Seq_MCF-7_Human1.10012808
110E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.09003987
111STAT6_21828071_ChIP-Seq_BEAS2B_Human1.08921122
112CREB1_26743006_Chip-Seq_LNCaP_Human1.08066034
113TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.08028895
114RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.07505435
115TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.07153590
116GATA2_19941826_ChIP-Seq_K562_Human1.06613909
117RUNX1_22412390_ChIP-Seq_EML_Mouse1.05283347
118RUNX_20019798_ChIP-Seq_JUKART_Human1.05038385
119GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03960870
120GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.03690657
121YAP1_20516196_ChIP-Seq_MESCs_Mouse1.02898086
122CDX2_19796622_ChIP-Seq_MESCs_Mouse1.02734845
123MAF_26560356_Chip-Seq_TH1_Human1.02255349
124RXR_22108803_ChIP-Seq_LS180_Human1.02111035
125PIAS1_25552417_ChIP-Seq_VCAP_Human1.01620671
126* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.01387018
127IRF8_27001747_Chip-Seq_BMDM_Mouse1.01201612
128PRDM14_20953172_ChIP-Seq_ESCs_Human1.00903671
129TCF4_23295773_ChIP-Seq_U87_Human1.00751762
130PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.00558210
131GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.00531034
132GATA2_21666600_ChIP-Seq_HMVEC_Human1.00022497
133ARNT_22903824_ChIP-Seq_MCF-7_Human0.99824058
134TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.99817528
135CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.99344156
136UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.97714574
137SMAD3_21741376_ChIP-Seq_HESCs_Human0.97132904
138CTCF_27219007_Chip-Seq_ERYTHROID_Human0.96985249
139GATA1_19941827_ChIP-Seq_MEL86_Mouse0.96904281
140* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.94909463
141VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.94849309
142SMC4_20622854_ChIP-Seq_HELA_Human0.94543464
143MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.94452408
144RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.93422742
145AHR_22903824_ChIP-Seq_MCF-7_Human0.92836155
146NR3C1_21868756_ChIP-Seq_MCF10A_Human0.92300975
147SMAD3_21741376_ChIP-Seq_ESCs_Human0.92235737
148AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.91462973
149SMAD4_21741376_ChIP-Seq_HESCs_Human0.89916439
150CBX2_27304074_Chip-Seq_ESCs_Mouse0.89714299
151RUNX2_22187159_ChIP-Seq_PCA_Human0.89071006
152IGF1R_20145208_ChIP-Seq_DFB_Human0.86479983
153UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.86347116
154ZFP281_27345836_Chip-Seq_ESCs_Mouse0.86252275
155JUN_21703547_ChIP-Seq_K562_Human0.85262169
156BCAT_22108803_ChIP-Seq_LS180_Human0.84768277
157FUS_26573619_Chip-Seq_HEK293_Human0.84628198
158TP53_18474530_ChIP-ChIP_U2OS_Human0.84361598
159TET1_21490601_ChIP-Seq_MESCs_Mouse0.83925230
160BMI1_23680149_ChIP-Seq_NPCS_Mouse0.82505532

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity7.59892860
2MP0003880_abnormal_central_pattern5.14349493
3* MP0003635_abnormal_synaptic_transmissio4.44052674
4MP0004270_analgesia3.93681045
5MP0009745_abnormal_behavioral_response3.62239188
6* MP0002063_abnormal_learning/memory/cond3.59186001
7MP0002822_catalepsy3.39160553
8MP0002064_seizures3.28530073
9MP0001968_abnormal_touch/_nociception2.98173223
10MP0009046_muscle_twitch2.90761358
11MP0002572_abnormal_emotion/affect_behav2.89292248
12MP0002272_abnormal_nervous_system2.60097854
13MP0001486_abnormal_startle_reflex2.55329543
14MP0002734_abnormal_mechanical_nocicepti2.45218708
15MP0001501_abnormal_sleep_pattern2.43190881
16MP0005423_abnormal_somatic_nervous2.35023314
17MP0003705_abnormal_hypodermis_morpholog2.34321333
18MP0008260_abnormal_autophagy2.32939476
19MP0002736_abnormal_nociception_after2.28399382
20MP0003303_peritoneal_inflammation2.17298530
21MP0001440_abnormal_grooming_behavior2.10272495
22MP0009780_abnormal_chondrocyte_physiolo2.03269096
23MP0002735_abnormal_chemical_nociception2.02400988
24MP0003329_amyloid_beta_deposits2.01106649
25MP0002909_abnormal_adrenal_gland1.97185695
26MP0008569_lethality_at_weaning1.90860455
27MP0002733_abnormal_thermal_nociception1.87964743
28MP0001970_abnormal_pain_threshold1.86417536
29MP0004811_abnormal_neuron_physiology1.85420918
30MP0002067_abnormal_sensory_capabilities1.84598443
31MP0001348_abnormal_lacrimal_gland1.76085467
32MP0004858_abnormal_nervous_system1.75481537
33MP0005386_behavior/neurological_phenoty1.73110171
34MP0004924_abnormal_behavior1.73110171
35MP0003879_abnormal_hair_cell1.65028289
36MP0002184_abnormal_innervation1.63675806
37MP0003656_abnormal_erythrocyte_physiolo1.60913451
38MP0002877_abnormal_melanocyte_morpholog1.59893250
39* MP0002557_abnormal_social/conspecific_i1.56961325
40MP0005646_abnormal_pituitary_gland1.56188021
41MP0000778_abnormal_nervous_system1.52066072
42MP0003633_abnormal_nervous_system1.45490868
43MP0000955_abnormal_spinal_cord1.44910086
44MP0003300_gastrointestinal_ulcer1.43423271
45* MP0002066_abnormal_motor_capabilities/c1.38251756
46MP0003787_abnormal_imprinting1.37655675
47MP0001984_abnormal_olfaction1.37403045
48MP0005451_abnormal_body_composition1.35532887
49MP0003191_abnormal_cellular_cholesterol1.35240348
50MP0002882_abnormal_neuron_morphology1.32432116
51MP0004885_abnormal_endolymph1.30489288
52MP0003075_altered_response_to1.29984738
53MP0001529_abnormal_vocalization1.27801537
54MP0003091_abnormal_cell_migration1.26978529
55MP0010234_abnormal_vibrissa_follicle1.23801722
56MP0001502_abnormal_circadian_rhythm1.23023193
57MP0005076_abnormal_cell_differentiation1.21568393
58MP0006276_abnormal_autonomic_nervous1.21098569
59MP0003566_abnormal_cell_adhesion1.20795623
60MP0005464_abnormal_platelet_physiology1.19657085
61MP0004185_abnormal_adipocyte_glucose1.18378220
62MP0003123_paternal_imprinting1.18002589
63MP0003631_nervous_system_phenotype1.17528062
64MP0003436_decreased_susceptibility_to1.13225825
65MP0001851_eye_inflammation1.11779595
66MP0001905_abnormal_dopamine_level1.09875819
67MP0003828_pulmonary_edema1.08858728
68MP0000013_abnormal_adipose_tissue1.08458007
69MP0000751_myopathy1.08313882
70MP0008874_decreased_physiological_sensi1.08059953
71MP0008872_abnormal_physiological_respon1.05788133
72MP0004510_myositis1.02943177
73MP0002152_abnormal_brain_morphology1.02544579
74MP0001188_hyperpigmentation0.99383796
75MP0000569_abnormal_digit_pigmentation0.99091955
76MP0003183_abnormal_peptide_metabolism0.98420466
77MP0004145_abnormal_muscle_electrophysio0.98075943
78MP0004947_skin_inflammation0.97999582
79MP0000604_amyloidosis0.97011968
80MP0005058_abnormal_lysosome_morphology0.95434525
81MP0003045_fibrosis0.95406625
82MP0002069_abnormal_eating/drinking_beha0.94771766
83MP0008961_abnormal_basal_metabolism0.94051664
84MP0005645_abnormal_hypothalamus_physiol0.93776509
85MP0005535_abnormal_body_temperature0.93125198
86MP0001177_atelectasis0.91602895
87MP0004142_abnormal_muscle_tone0.91317523
88MP0010386_abnormal_urinary_bladder0.89370594
89MP0001849_ear_inflammation0.88546558
90MP0002837_dystrophic_cardiac_calcinosis0.86010434
91MP0002229_neurodegeneration0.85712293
92MP0002133_abnormal_respiratory_system0.83184822
93MP0005388_respiratory_system_phenotype0.83184822
94MP0004147_increased_porphyrin_level0.83165467
95MP0005167_abnormal_blood-brain_barrier0.82001629
96MP0005666_abnormal_adipose_tissue0.81197177
97MP0004484_altered_response_of0.81074800
98MP0004085_abnormal_heartbeat0.80914493
99MP0002090_abnormal_vision0.80667248
100MP0003690_abnormal_glial_cell0.80625747
101MP0005621_abnormal_cell_physiology0.79698055
102MP0003122_maternal_imprinting0.76380947
103MP0003453_abnormal_keratinocyte_physiol0.75551728
104MP0004215_abnormal_myocardial_fiber0.75167799
105MP0002089_abnormal_postnatal_growth/wei0.74781234
106MP0005551_abnormal_eye_electrophysiolog0.74238800
107MP0003634_abnormal_glial_cell0.73183942
108MP0003632_abnormal_nervous_system0.72276776
109MP0003763_abnormal_thymus_physiology0.72028295
110MP0009278_abnormal_bone_marrow0.71924531
111MP0003283_abnormal_digestive_organ0.70888274
112MP0000920_abnormal_myelination0.70170807
113MP0002419_abnormal_innate_immunity0.69959533
114MP0002998_abnormal_bone_remodeling0.69118019
115MP0003724_increased_susceptibility_to0.68520230
116MP0004233_abnormal_muscle_weight0.68485744
117MP0002009_preneoplasia0.68299444
118MP0001963_abnormal_hearing_physiology0.68060329
119MP0001958_emphysema0.67690945
120MP0005000_abnormal_immune_tolerance0.66878182
121MP0005409_darkened_coat_color0.66867768
122MP0005623_abnormal_meninges_morphology0.66862792
123MP0005394_taste/olfaction_phenotype0.66258438
124MP0005499_abnormal_olfactory_system0.66258438
125MP0000759_abnormal_skeletal_muscle0.64514300
126MP0002971_abnormal_brown_adipose0.64031684
127MP0004742_abnormal_vestibular_system0.62888256
128MP0001664_abnormal_digestion0.62213118
129MP0000858_altered_metastatic_potential0.61397481
130MP0004808_abnormal_hematopoietic_stem0.60501510
131MP0004087_abnormal_muscle_fiber0.60478924
132MP0005375_adipose_tissue_phenotype0.60297540
133MP0002332_abnormal_exercise_endurance0.60144487
134MP0005166_decreased_susceptibility_to0.59799101
135MP0003172_abnormal_lysosome_physiology0.58363362
136MP0004130_abnormal_muscle_cell0.57098183
137MP0001485_abnormal_pinna_reflex0.56665685
138MP0000631_abnormal_neuroendocrine_gland0.56051649
139MP0002752_abnormal_somatic_nervous0.55804701
140MP0002876_abnormal_thyroid_physiology0.54856911
141MP0005187_abnormal_penis_morphology0.52828519
142MP0001765_abnormal_ion_homeostasis0.52454039
143MP0004043_abnormal_pH_regulation0.51858433
144MP0001943_abnormal_respiration0.50738733
145MP0000747_muscle_weakness0.49225423

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)8.40662218
2Myokymia (HP:0002411)7.56718496
3Focal seizures (HP:0007359)6.12136329
4Visual hallucinations (HP:0002367)5.54979654
5Epileptic encephalopathy (HP:0200134)4.94242500
6Atonic seizures (HP:0010819)4.75304529
7Absence seizures (HP:0002121)4.53443399
8Febrile seizures (HP:0002373)4.44234131
9Generalized tonic-clonic seizures (HP:0002069)4.11437372
10Dialeptic seizures (HP:0011146)4.09709569
11Progressive cerebellar ataxia (HP:0002073)4.09334806
12Action tremor (HP:0002345)4.08538940
13Poor eye contact (HP:0000817)3.76012307
14Impaired vibration sensation in the lower limbs (HP:0002166)3.66731805
15Supranuclear gaze palsy (HP:0000605)3.60538799
16Depression (HP:0000716)3.55829456
17Broad-based gait (HP:0002136)3.53669006
18Papilledema (HP:0001085)3.53512180
19Abnormal social behavior (HP:0012433)3.37203972
20Impaired social interactions (HP:0000735)3.37203972
21Ankle clonus (HP:0011448)3.36879670
22Anxiety (HP:0000739)3.28391028
23Gaze-evoked nystagmus (HP:0000640)3.26878647
24Hyperventilation (HP:0002883)3.24756549
25Dysmetria (HP:0001310)3.23922785
26Dysdiadochokinesis (HP:0002075)3.22240191
27Amblyopia (HP:0000646)3.19480993
28Truncal ataxia (HP:0002078)3.12755136
29Urinary bladder sphincter dysfunction (HP:0002839)3.09577282
30Postural instability (HP:0002172)3.07242629
31Abnormality of the lower motor neuron (HP:0002366)3.04161495
32Mutism (HP:0002300)2.90112450
33Slow saccadic eye movements (HP:0000514)2.88316033
34Urinary urgency (HP:0000012)2.85579436
35Impaired smooth pursuit (HP:0007772)2.84533347
36Abnormal eating behavior (HP:0100738)2.84401510
37Torticollis (HP:0000473)2.82377864
38Cerebral inclusion bodies (HP:0100314)2.80129179
39Stereotypic behavior (HP:0000733)2.78503424
40Annular pancreas (HP:0001734)2.78442404
41Focal dystonia (HP:0004373)2.70262928
42Tetraplegia (HP:0002445)2.65333648
43Drooling (HP:0002307)2.62491601
44Excessive salivation (HP:0003781)2.62491601
45Scanning speech (HP:0002168)2.61462555
46Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.61188338
47Bradykinesia (HP:0002067)2.60649348
48Neurofibrillary tangles (HP:0002185)2.56624367
49Dysmetric saccades (HP:0000641)2.55541204
50Intention tremor (HP:0002080)2.54918871
51Genetic anticipation (HP:0003743)2.51050184
52Epileptiform EEG discharges (HP:0011182)2.49303341
53Ventricular fibrillation (HP:0001663)2.48757352
54Impaired vibratory sensation (HP:0002495)2.45969557
55Abnormality of ocular smooth pursuit (HP:0000617)2.43506732
56Diplopia (HP:0000651)2.43353990
57Abnormality of binocular vision (HP:0011514)2.43353990
58Progressive inability to walk (HP:0002505)2.42819886
59Spastic gait (HP:0002064)2.42296960
60Insidious onset (HP:0003587)2.41780929
61Termporal pattern (HP:0011008)2.41780929
62Hemiparesis (HP:0001269)2.41175212
63Megalencephaly (HP:0001355)2.36504814
64Pointed chin (HP:0000307)2.35642028
65Status epilepticus (HP:0002133)2.35107145
66Ankyloglossia (HP:0010296)2.33921481
67Craniofacial dystonia (HP:0012179)2.33859338
68Resting tremor (HP:0002322)2.32102696
69EEG with generalized epileptiform discharges (HP:0011198)2.30712829
70Absent speech (HP:0001344)2.29370037
71Hemiplegia (HP:0002301)2.29201998
72Fetal akinesia sequence (HP:0001989)2.21727712
73Peripheral hypomyelination (HP:0007182)2.16606716
74Generalized myoclonic seizures (HP:0002123)2.16425814
75Hypsarrhythmia (HP:0002521)2.16016488
76Incomplete penetrance (HP:0003829)2.11150325
77Lower limb asymmetry (HP:0100559)2.10341857
78Bundle branch block (HP:0011710)2.09317922
79Diminished motivation (HP:0000745)2.09143893
80Lower limb muscle weakness (HP:0007340)2.09032830
81Inability to walk (HP:0002540)2.05623847
82Decreased motor nerve conduction velocity (HP:0003431)2.02232344
83Delusions (HP:0000746)2.01507094
84Rapidly progressive (HP:0003678)2.01453307
85Gait ataxia (HP:0002066)2.00635557
86Lower limb amyotrophy (HP:0007210)1.99577233
87Cerebral aneurysm (HP:0004944)1.98142649
88Inappropriate behavior (HP:0000719)1.96700689
89Insomnia (HP:0100785)1.96694783
90Difficulty running (HP:0009046)1.96355659
91Foot dorsiflexor weakness (HP:0009027)1.92023978
92Pheochromocytoma (HP:0002666)1.90191047
93Apathy (HP:0000741)1.89824957
94Amyotrophic lateral sclerosis (HP:0007354)1.89644815
95Neuronal loss in central nervous system (HP:0002529)1.88594745
96Eczematoid dermatitis (HP:0000976)1.86274521
97Bowel incontinence (HP:0002607)1.85911244
98Obstructive sleep apnea (HP:0002870)1.85531833
99Arterial tortuosity (HP:0005116)1.84960917
100Rigidity (HP:0002063)1.84157190
101Clonus (HP:0002169)1.83581358
102Abnormal EKG (HP:0003115)1.80632555
103Psychosis (HP:0000709)1.79441067
104Cellulitis (HP:0100658)1.78924804
105Abnormality of the periventricular white matter (HP:0002518)1.78430528
106Hypercortisolism (HP:0001578)1.77723572
107Abnormality of salivation (HP:0100755)1.77690454
108Intellectual disability, profound (HP:0002187)1.77353599
109Distal lower limb amyotrophy (HP:0008944)1.77066415
110Agitation (HP:0000713)1.76889437
111Abnormality of the corticospinal tract (HP:0002492)1.74836767
112Hyporeflexia of lower limbs (HP:0002600)1.74580968
113Blue irides (HP:0000635)1.74576150
114Abnormality of oral frenula (HP:0000190)1.74422810
115Abnormality of saccadic eye movements (HP:0000570)1.74352185
116Spontaneous hematomas (HP:0007420)1.73027804
117Hyperacusis (HP:0010780)1.72760884
118Deep palmar crease (HP:0006191)1.72660533
119Upper limb amyotrophy (HP:0009129)1.71527405
120Distal upper limb amyotrophy (HP:0007149)1.71527405
121Abnormal large intestine physiology (HP:0012700)1.71136085
122Increased variability in muscle fiber diameter (HP:0003557)1.70435693
123Abnormality of the foot musculature (HP:0001436)1.69125525
124Distal sensory impairment (HP:0002936)1.69044572
125Onion bulb formation (HP:0003383)1.68805475
126Abnormality of skeletal muscle fiber size (HP:0012084)1.64160163
127Vascular tortuosity (HP:0004948)1.63739119
128Spinal canal stenosis (HP:0003416)1.62979155
129Akinesia (HP:0002304)1.62973759
130Slow progression (HP:0003677)1.59350016
131Hammertoe (HP:0001765)1.58386835
132Subacute progressive viral hepatitis (HP:0006572)1.57844857
133Subaortic stenosis (HP:0001682)1.57089087
134Abnormality of the left ventricular outflow tract (HP:0011103)1.57089087
135Centrally nucleated skeletal muscle fibers (HP:0003687)1.56060731
136Relative macrocephaly (HP:0004482)1.55960259
137Mask-like facies (HP:0000298)1.55788283

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA45.40573299
2NTRK34.68040567
3MAP3K94.07120352
4RIPK42.95313789
5KSR22.87250454
6MAP3K42.76833667
7DAPK22.68560080
8MINK12.67463338
9PAK62.32256686
10PRKD32.23088328
11MAP2K72.19193274
12MARK12.17216191
13CAMKK12.10758067
14KSR11.99389157
15MAP3K121.95651357
16ARAF1.87169344
17DAPK11.86612819
18MAP2K41.85832326
19MAP3K131.83104224
20CDK121.74728491
21NTRK11.74053332
22TRIB31.73499437
23NTRK21.56854673
24MAP3K21.56406711
25CDK51.54416452
26PLK21.42894911
27MAP2K31.37385944
28CDK191.37099527
29STK381.35299829
30RAF11.34221166
31FES1.32590574
32CAMKK21.25877163
33GRK51.24383905
34SIK21.23703776
35WNK11.23641650
36ICK1.21015741
37PRPF4B1.19739512
38PRKCG1.15866148
39BMPR21.11536917
40PTK2B1.10791596
41TYRO31.08243241
42TAOK11.07407387
43TNIK1.05708693
44TAOK21.01158647
45PNCK1.00593950
46SMG10.96120447
47EEF2K0.95442500
48CAMK2A0.93964470
49MAP3K110.91196198
50CAMK10.91022012
51CDK180.90268844
52RET0.88933374
53UHMK10.88792234
54CDK150.88452027
55CDK140.88142985
56JAK10.86709807
57CASK0.86269218
58MAPK130.83753107
59PDGFRA0.82926079
60PDK10.82477776
61MAP3K10.82225959
62CAMK2B0.81978698
63PINK10.81451056
64IRAK20.80573580
65STK110.80340210
66LATS20.79609475
67ERN10.79608306
68PRKCH0.78951115
69FGFR30.77440891
70JAK20.77172238
71CDK11A0.76952935
72PAK30.75327346
73PDPK10.73745047
74FGFR40.71855963
75SGK4940.69959279
76SGK2230.69959279
77ALK0.69115978
78NEK10.68887778
79MAP3K140.68397684
80SGK10.67169494
81SCYL20.63235943
82TTN0.61403655
83MAP2K10.60381119
84SGK20.59081884
85PHKG20.58812116
86PHKG10.58812116
87SGK30.58675244
88CAMK1D0.56441716
89TNK20.55342282
90LMTK20.54521549
91MAP3K70.54347731
92OXSR10.53891638
93NME10.53251869
94DYRK1A0.52560606
95RIPK10.51366336
96FGR0.50256113
97ZAP700.49771480
98MARK20.49584130
99DMPK0.49188581
100SYK0.48788760
101SIK10.48762937
102MOS0.48264691
103CSK0.47724299
104FER0.47253750
105BRD40.45604789
106RPS6KA30.45530399
107GRK60.44753059
108HIPK20.44379941
109PRKCZ0.43595638
110FYN0.43223599
111DAPK30.42872084
112PDGFRB0.42624114
113BLK0.42565808
114MAPK100.42221872
115ROCK20.42132405
116YES10.42018713
117SIK30.41715526
118MAP3K30.40262754
119CSNK1G20.40068472
120BMX0.39766521
121CAMK2D0.38705213
122BRSK10.38481133
123CCNB10.37523268
124CAMK40.36688568
125BRAF0.36427516
126PRKCE0.36280868
127CAMK2G0.36249273
128CAMK1G0.32950952
129MAP3K60.28163017
130PRKCB0.27735526
131NEK60.27459653
132MAPK120.26441027
133CDC42BPA0.25469374

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.46830709
2Synaptic vesicle cycle_Homo sapiens_hsa047213.09252838
3* Long-term potentiation_Homo sapiens_hsa047202.85922564
4Olfactory transduction_Homo sapiens_hsa047402.83627058
5Circadian entrainment_Homo sapiens_hsa047132.74639064
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.60671763
7GABAergic synapse_Homo sapiens_hsa047272.54633049
8* Glutamatergic synapse_Homo sapiens_hsa047242.48294715
9* Amphetamine addiction_Homo sapiens_hsa050312.47976685
10Morphine addiction_Homo sapiens_hsa050322.42935438
11Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.30883186
12Salivary secretion_Homo sapiens_hsa049702.26923089
13Dopaminergic synapse_Homo sapiens_hsa047282.20767117
14Gastric acid secretion_Homo sapiens_hsa049711.99906512
15Insulin secretion_Homo sapiens_hsa049111.99269603
16Cholinergic synapse_Homo sapiens_hsa047251.94407814
17Aldosterone synthesis and secretion_Homo sapiens_hsa049251.93193185
18* Oxytocin signaling pathway_Homo sapiens_hsa049211.76437730
19Long-term depression_Homo sapiens_hsa047301.72985967
20Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.71447580
21* Renin secretion_Homo sapiens_hsa049241.65712254
22GnRH signaling pathway_Homo sapiens_hsa049121.60994105
23* Calcium signaling pathway_Homo sapiens_hsa040201.58317929
24Taste transduction_Homo sapiens_hsa047421.58166050
25Cocaine addiction_Homo sapiens_hsa050301.56645926
26Serotonergic synapse_Homo sapiens_hsa047261.55266400
27Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.52620196
28Gap junction_Homo sapiens_hsa045401.36447442
29Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.35077804
30Glioma_Homo sapiens_hsa052141.32350035
31Collecting duct acid secretion_Homo sapiens_hsa049661.32085898
32Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.31042747
33cAMP signaling pathway_Homo sapiens_hsa040241.29858634
34Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.29530148
35Chronic myeloid leukemia_Homo sapiens_hsa052201.28534466
36Nitrogen metabolism_Homo sapiens_hsa009101.21554132
37Phosphatidylinositol signaling system_Homo sapiens_hsa040701.20404601
38* B cell receptor signaling pathway_Homo sapiens_hsa046621.20109943
39Estrogen signaling pathway_Homo sapiens_hsa049151.19544529
40Type II diabetes mellitus_Homo sapiens_hsa049301.15352081
41Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.07916310
42Melanogenesis_Homo sapiens_hsa049161.06451341
43* cGMP-PKG signaling pathway_Homo sapiens_hsa040221.05720035
44Acute myeloid leukemia_Homo sapiens_hsa052211.05645214
45Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.04672820
46ErbB signaling pathway_Homo sapiens_hsa040121.04619865
47Pancreatic cancer_Homo sapiens_hsa052121.03361535
48Vascular smooth muscle contraction_Homo sapiens_hsa042700.98654599
49AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.97574651
50Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.96659581
51* Osteoclast differentiation_Homo sapiens_hsa043800.95693651
52Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.93345676
53Pancreatic secretion_Homo sapiens_hsa049720.93254617
54Dorso-ventral axis formation_Homo sapiens_hsa043200.90536499
55* Oocyte meiosis_Homo sapiens_hsa041140.88803001
56Prolactin signaling pathway_Homo sapiens_hsa049170.87719236
57Phospholipase D signaling pathway_Homo sapiens_hsa040720.86539273
58Cardiac muscle contraction_Homo sapiens_hsa042600.85174780
59Vibrio cholerae infection_Homo sapiens_hsa051100.84351278
60Thyroid hormone synthesis_Homo sapiens_hsa049180.83821771
61* Axon guidance_Homo sapiens_hsa043600.83448370
62Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.82815272
63Choline metabolism in cancer_Homo sapiens_hsa052310.79209795
64Toll-like receptor signaling pathway_Homo sapiens_hsa046200.78948055
65* T cell receptor signaling pathway_Homo sapiens_hsa046600.76919176
66Thyroid cancer_Homo sapiens_hsa052160.75979037
67HIF-1 signaling pathway_Homo sapiens_hsa040660.74841282
68Neurotrophin signaling pathway_Homo sapiens_hsa047220.74576880
69Leukocyte transendothelial migration_Homo sapiens_hsa046700.74395147
70* VEGF signaling pathway_Homo sapiens_hsa043700.73702399
71Dilated cardiomyopathy_Homo sapiens_hsa054140.71608511
72Amoebiasis_Homo sapiens_hsa051460.71225076
73Phototransduction_Homo sapiens_hsa047440.69916888
74* Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.68653815
75mTOR signaling pathway_Homo sapiens_hsa041500.68326034
76* Tuberculosis_Homo sapiens_hsa051520.68277847
77Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.68199131
78Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.67911046
79* MAPK signaling pathway_Homo sapiens_hsa040100.67654012
80Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.67279139
81Leishmaniasis_Homo sapiens_hsa051400.67082110
82Carbohydrate digestion and absorption_Homo sapiens_hsa049730.66150642
83Proteoglycans in cancer_Homo sapiens_hsa052050.65619585
84FoxO signaling pathway_Homo sapiens_hsa040680.65255754
85AMPK signaling pathway_Homo sapiens_hsa041520.63152126
86Rap1 signaling pathway_Homo sapiens_hsa040150.62904568
87Non-small cell lung cancer_Homo sapiens_hsa052230.62333330
88Colorectal cancer_Homo sapiens_hsa052100.61947494
89Focal adhesion_Homo sapiens_hsa045100.61643013
90Adipocytokine signaling pathway_Homo sapiens_hsa049200.61418875
91Hepatitis B_Homo sapiens_hsa051610.61083285
92Sphingolipid signaling pathway_Homo sapiens_hsa040710.60329458
93Thyroid hormone signaling pathway_Homo sapiens_hsa049190.59107363
94* Glucagon signaling pathway_Homo sapiens_hsa049220.58558982
95African trypanosomiasis_Homo sapiens_hsa051430.58360850
96Ras signaling pathway_Homo sapiens_hsa040140.58017182
97Endocytosis_Homo sapiens_hsa041440.53588180
98Salmonella infection_Homo sapiens_hsa051320.53161621
99Inositol phosphate metabolism_Homo sapiens_hsa005620.51224225
100Type I diabetes mellitus_Homo sapiens_hsa049400.50684974
101Adherens junction_Homo sapiens_hsa045200.50143491
102Hepatitis C_Homo sapiens_hsa051600.50062243
103Prion diseases_Homo sapiens_hsa050200.50032770
104Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.46868533
105Circadian rhythm_Homo sapiens_hsa047100.46542527
106Longevity regulating pathway - mammal_Homo sapiens_hsa042110.44115640
107Renal cell carcinoma_Homo sapiens_hsa052110.44087856
108Endometrial cancer_Homo sapiens_hsa052130.43827956
109Chemokine signaling pathway_Homo sapiens_hsa040620.43762247
110Alcoholism_Homo sapiens_hsa050340.43263447
111Insulin signaling pathway_Homo sapiens_hsa049100.42892592
112Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.42143254
113Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.41804610
114Bile secretion_Homo sapiens_hsa049760.41630841
115Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.39545597
116Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.37487834
117Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.35955934
118Platelet activation_Homo sapiens_hsa046110.34673180
119Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.30894304
120* Wnt signaling pathway_Homo sapiens_hsa043100.30033836
121* Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.28783947
122Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.28136680
123Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.27567919
124Regulation of actin cytoskeleton_Homo sapiens_hsa048100.27245581
125Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.27158882
126Ovarian steroidogenesis_Homo sapiens_hsa049130.26132348
127Central carbon metabolism in cancer_Homo sapiens_hsa052300.25766320

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